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Safety Data Sheet Material Name: Sodium Salt CertiMass SDS ID: 1223P Solution

Section 1 - PRODUCT AND COMPANY IDENTIFICATION

Material Name Dehydroepiandrosterone Sulfate Sodium Salt CertiMass Solution Product Code S9180UNL Product Use fine chemical Restrictions on Use Material for use only in TSCA exempt applications: Substances used for research and development, , foods and food additives, drugs, and cosmetics. Details of the supplier of the safety data sheet Entegris, Inc. 129 Concord Road Building 2 Billerica, MA 01821 USA

Telephone Number: +1-952-556-4181 Telephone Number: +1-800-394-4083 (toll free within North America)

Emergency Telephone Number: CHEMTREC - U.S. - 1-800-424-9300 CHEMTREC - Intl. - 1-703-527-3887 E-mail: [email protected]

Section 2 - HAZARDS IDENTIFICATION

Classification in accordance with paragraph (d) of 29 CFR 1910.1200. Flammable Liquids - Category 2 Acute Toxicity - Oral - Category 3 Acute Toxicity - Dermal - Category 3 Acute Toxicity - Inhalation - Vapor - Category 3 Skin Corrosion/Irritation - Category 2 Serious Eye Damage/Eye Irritation - Category 2A Carcinogenicity - Category 2 Reproductive Toxicity - Category 1B Specific Target Organ Toxicity - Single Exposure - Category 1 ( central nervous system , eyes , systemic toxicity , nervous system ) Specific Target Organ Toxicity - Single Exposure - Category 3 ( respiratory system , central nervous system ) Specific Target Organ Toxicity - Repeated Exposure - Category 1 ( central nervous system , eyes ) GHS Label Elements Symbol(s)

______Page 1 of 11 Issue date: 2021-04-27 Revision 1.0 Print date: 2021-04-28

Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Signal Word Danger Hazard Statement(s) Highly flammable liquid and vapor. Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. Suspected of causing cancer. May damage fertility or the unborn child. Causes damage to organs. （central nervous system , eyes , systemic toxicity , nervous system ） May cause respiratory irritation. May cause drowsiness or dizziness. Causes damage to organs through prolonged or repeated exposure. （central nervous system , eyes ） Precautionary Statement(s) Prevention Keep away from heat/sparks/open flame/hot surfaces - No smoking. Keep container tightly closed. Ground/Bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary measures against static discharge. Use only non-sparking tools. Use only outdoors or in a well-ventilated area. Do not breathe vapor or mist. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Response In case of fire: Use appropriate media to extinguish. If exposed: Call a POISON CENTER or doctor/physician. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Specific treatment may be needed, see first aid section of Safety Data Sheet. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation occurs: Get medical advice/attention. Take off immediately all contaminated clothing and wash it before reuse. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

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Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Storage Store in a well-ventilated place. Keep container tightly closed. Keep cool. Store locked up. Disposal Dispose of contents/container in accordance with local/regional/national/international regulations. Other Hazards None known.

Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS

CAS Component Name Percent

67-56-1 Methanol ≥ 90 - ≤ 100

78590-17-7 Sodium sulfate dihydrate ≥0.01 - ˂1 The chemical identity and/or percentage of composition is being withheld as a trade secret.

Section 4 - FIRST AID MEASURES

Inhalation If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate medical attention. Skin Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. Eyes Immediately flush eyes with water for at least 15 minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Then get immediate medical attention. Ingestion If swallowed, get medical attention. Most Important Symptoms/Effects Acute Toxic if swallowed, Toxic in contact with skin, Toxic if inhaled, respiratory tract irritation, skin irritation, eye irritation, central nervous system depression, central nervous system damage, eye damage, systemic toxicity damage, nervous system damage Delayed cancer, reproductive effects, central nervous system damage, eye damage Indication of any immediate medical attention and special treatment needed Treat symptomatically and supportively. Note to Physicians For inhalation, consider oxygen.

Section 5 - FIRE FIGHTING MEASURES

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Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Extinguishing Media Suitable Extinguishing Media regular dry chemical, carbon dioxide, water spray, -resistant foam. Large fires: water spray or alcohol-resistant foam Unsuitable Extinguishing Media high-pressure water streams Special Hazards Arising from the Chemical Highly flammable liquid and vapor. Vapor/air mixtures are explosive above flash point. Take precautionary measures against static discharge. Hazardous Combustion Products oxides of carbon Advice for firefighters Highly flammable liquid and vapor. Vapor/air mixtures are explosive above flash point. Take precautionary measures against static discharge. Fire Fighting Measures Move container from fire area if it can be done without risk. Do not scatter spilled material with high- pressure water streams. Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with water spray until well after the fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tanks due to fire. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible withdraw from area and let fire burn. Avoid inhalation of material or combustion by-products. Special Protective Equipment and Precautions for Firefighters Wear full protective fire fighting gear including self contained breathing apparatus (SCBA) for protection against possible exposure.

Section 6 - ACCIDENTAL RELEASE MEASURES

Personal Precautions, Protective Equipment and Emergency Procedures Wear personal protective clothing and equipment. Methods and Materials for Containment and Cleaning Up Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Additionally, for large spills: Water spray may reduce vapor, but may not prevent ignition in closed spaces. Do not touch or walk through spilled material. Stop leak if possible without personal risk. Prevent entry into waterways, sewers, basements, or confined areas. A vapor suppressing foam may be used to reduce vapors. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Use non-sparking tools during clean- up. Large spills: Dike far ahead of liquid spill for collection and later disposal. Environmental Precautions Avoid release to the environment.

Section 7 - HANDLING AND STORAGE

Precautions for Safe Handling Keep container tightly closed. Keep away from heat/sparks/open flame/hot surfaces - No smoking. Ground/Bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary measures against static discharge. Use only non-sparking tools. Use only outdoors or in a well-ventilated area. Do not breathe vapor or mist. Wash thoroughly after handling. Wear protective gloves/protective clothing/eye protection/face protection. Obtain special instructions before use. ______Page 4 of 11 Issue date: 2021-04-27 Revision 1.0 Print date: 2021-04-28

Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. Conditions for Safe Storage, Including any Incompatibilities Store in a well-ventilated place. Keep container tightly closed. Keep cool. Store locked up. Store in accordance with all current regulations and standards. Recommended storage temperature: -20 °C. Keep separated from incompatible substances. Incompatible Materials halo carbons, combustible materials, metals, oxidizing materials, halogens, metal carbide, bases, acids, amines, alkali metals, reducing agents

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

Component Exposure Limits Methanol 67-56-1

ACGIH: 200 ppm TWA

250 ppm STEL

Skin - potential significant contribution to overall exposure by the cutaneous route

NIOSH: 200 ppm TWA ; 260 mg/m3 TWA

250 ppm STEL ; 325 mg/m3 STEL

Potential for dermal absorption

6000 ppm IDLH

Europe: 200 ppm TWA ; 260 mg/m3 TWA

Possibility of significant uptake through the skin

OSHA (US): 200 ppm TWA ; 260 mg/m3 TWA

Mexico: 200 ppm TWA [VLE-PPT ]

250 ppm STEL [PPT-CT ]

Skin - potential for cutaneous absorption ACGIH - Threshold Limit Values - Biological Exposure Indices (BEI) Methanol (67-56-1) 15 mg/l Medium: urine Time: end of shift Parameter: Methanol (background, nonspecific ) Engineering Controls Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Provide local exhaust or process enclosure ventilation system. Ensure compliance with applicable exposure limits. ______Page 5 of 11 Issue date: 2021-04-27 Revision 1.0 Print date: 2021-04-28

Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Individual Protection Measures, such as Personal Protective Equipment Eye/face protection Wear splash resistant safety goggles with a faceshield. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. Skin Protection Wear appropriate chemical resistant clothing. Respiratory Protection Respirators depend on exposure level. SCBA with full face piece recommended during change outs and available in case of emergency. Glove Recommendations Wear appropriate chemical resistant gloves.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Appearance Colorless liquid Physical State liquid Odor pungent Color colorless Odor Threshold Not available Melting Point Not available Boiling Point 64.7 °C -98 °C (literature Boiling Point Range Not available Freezing point value ) Evaporation Rate Not available Flammability (solid, gas) Not applicable

Autoignition 455 °C at 1013 Flash Point 9.7 °C Temperature hPa Lower Explosive Decomposition 6 % (V) Not available Limit temperature Upper Explosive 130.3 hPa @ 20 36 % (V) Vapor Pressure Limit °C Vapor Density 1.11 Specific Gravity (water=1) 0.791 (air=1) (completely Partition coefficient: n- Water Solubility Log Pow: -0.77 miscible ) octanol/water

Viscosity Not available Kinematic viscosity Not available Solubility (Other) Not available Density 0.791 g/cm3 Physical Form liquid Molecular Weight 390.47

Section 10 - STABILITY AND REACTIVITY

Reactivity Stable at normal temperatures and pressure. Chemical Stability ______Page 6 of 11 Issue date: 2021-04-27 Revision 1.0 Print date: 2021-04-28

Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Stable at normal temperatures and pressure. Possibility of Hazardous Reactions Will not polymerize. Conditions to Avoid Avoid flames, sparks, and other sources of ignition. Avoid contact with incompatible materials. Incompatible Materials halo carbons, combustible materials, metals, oxidizing materials, halogens, metal carbide, bases, acids, amines, alkali metals, reducing agents Hazardous decomposition products Thermal decomposition products oxides of carbon

Section 11 - TOXICOLOGICAL INFORMATION

Information on Likely Routes of Exposure Inhalation Toxic if inhaled, respiratory tract irritation, central nervous system depression, central nervous system damage Skin Contact Toxic in contact with skin, irritation Eye Contact irritation, eye damage Ingestion Toxic if swallowed. Acute and Chronic Toxicity Component Analysis - LD50/LC50 The components of this material have been reviewed in various sources and the following selected endpoints are published: Methanol (67-56-1) Oral LD50 Rat 6200 mg/kg Dermal LD50 Rabbit 15840 mg/kg Inhalation LC50 Rat 22500 ppm 8 h Product Toxicity Data Acute Toxicity Estimate No data available. Immediate Effects Toxic if swallowed, Toxic in contact with skin, Toxic if inhaled, respiratory tract irritation, skin irritation, eye irritation, central nervous system depression, central nervous system damage, eye damage, systemic toxicity damage, nervous system damage Delayed Effects cancer, reproductive effects, central nervous system damage, eye damage Irritation/Corrosivity Data respiratory tract irritation, skin irritation, eye irritation Respiratory Sensitization No data available for the mixture. Dermal Sensitization No data available for the mixture. Component Carcinogenicity None of this product's components are listed by ACGIH, IARC, NTP, DFG or OSHA.

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Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Germ Cell Mutagenicity No data available for the mixture. Tumorigenic Data No data available for the mixture. Reproductive Toxicity reproductive effects Specific Target Organ Toxicity - Single Exposure central nervous system, eyes, systemic system, nervous system, respiratory system Specific Target Organ Toxicity - Repeated Exposure central nervous system, eyes Aspiration hazard No data available. Medical Conditions Aggravated by Exposure No data available.

Section 12 - ECOLOGICAL INFORMATION

Component Analysis - Aquatic Toxicity Methanol 67-56-1

LC50 96 h Pimephales promelas 28200 mg/L [flow-through ]; LC50 96 h Pimephales promelas >100 mg/L [static ]; LC50 96 h Oncorhynchus mykiss 19500 - 20700 mg/L [flow- Fish: through ]; LC50 96 h Oncorhynchus mykiss 18 - 20 mL/L [static ]; LC50 96 h Lepomis macrochirus 13500 - 17600 mg/L [flow-through ] Persistence and Degradability No data available for the mixture. Bioaccumulative Potential No data available for the mixture. Mobility No data available for the mixture. Other Toxicity None known.

Section 13 - DISPOSAL CONSIDERATIONS

Disposal Methods Dispose in accordance with all applicable regulations. Subject to disposal regulations: U.S. EPA 40 CFR 262. Hazardous Waste Number(s): D001. Component Waste Numbers Methanol 67-56-1 Series

RCRA: waste number U154 (Ignitable waste ) U

Section 14 - TRANSPORT INFORMATION

US DOT Information: Shipping Name: METHANOL , Solution

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Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Hazard Class: 3 UN/NA #: UN1230 Packing Group: II Required Label(s): 3, 6.1

IATA Information: Shipping Name: METHANOL , Solution Hazard Class: 3 UN#: UN1230 Packing Group: II Required Label(s): 3, 6.1

IMDG Information: Shipping Name: METHANOL , Solution Hazard Class: 3 UN#: UN1230 Packing Group: II Required Label(s): 3, 6.1 International Bulk Chemical Code This material contains one or more of the following chemicals required by the IBC Code to be identified as dangerous chemicals in bulk. Methanol 67-56-1

IBC Code: Category Y

Section 15 - REGULATORY INFORMATION

U.S. Federal Regulations This material contains one or more of the following chemicals required to be identified under SARA Section 302 (40 CFR 355 Appendix A), SARA Section 313 (40 CFR 372.65), CERCLA (40 CFR 302.4), TSCA 12(b), and/or require an OSHA process safety plan. Methanol 67-56-1

SARA 313: 1 % de minimis concentration

CERCLA: 5000 lb final RQ ; 2270 kg final RQ SARA Section 311/312 (40 CFR 370 Subparts B and C) reporting categories Flammable; Carcinogenicity; Acute toxicity; Reproductive Toxicity; Skin Corrosion/Irritation; Serious Eye Damage/Eye Irritation; Specific Target Organ Toxicity U.S. State Regulations The following components appear on one or more of the following state hazardous substances lists: Component CAS CA MA MN NJ PA

Methanol 67-56-1 Yes Yes Yes Yes Yes California Safe Drinking Water and Toxic Enforcement Act (Proposition 65)

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Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

WARNING

This product can expose you to chemicals including Methanol , which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov. Methanol 67-56-1

Repro/Dev. Tox developmental toxicity , 3/16/2012 Component Analysis - Inventory Methanol (67-56-1) US CA AU CN EU JP - ENCS JP - ISHL KR KECI - Annex 1 KR KECI - Annex 2

Yes DSL Yes Yes EIN Yes Yes Yes No

KR - REACH CCA MX NZ PH TH-TECI TW VN (Draft)

Yes Yes Yes Yes Yes Yes Yes

Sodium prasterone sulfate dihydrate (78590-17-7) US CA AU CN EU JP - ENCS JP - ISHL KR KECI - Annex 1 KR KECI - Annex 2

No No No No No No No No No

KR - REACH CCA MX NZ PH TH-TECI TW VN (Draft)

No No No No No Yes No U.S. Inventory (TSCA) One or more components are not listed on the TSCA inventory.

Section 16 - OTHER INFORMATION

NFPA Ratings Health: 2 Fire: 3 Instability: 0 Hazard Scale: 0 = Minimal 1 = Slight 2 = Moderate 3 = Serious 4 = Severe Summary of Changes 04/27/2021 - Update to Section(s) 1. Preparation Date 10/13/2020 Revision date 04/27/2021

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Safety Data Sheet Material Name: Dehydroepiandrosterone Sulfate Sodium Salt CertiMass SDS ID: 1223P Solution

Key / Legend ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CA/MA/MN/NJ/PA - California/Massachusetts/Minnesota/New Jersey/Pennsylvania*; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CFR - Code of Federal Regulations (US); CLP - Classification, Labelling, and Packaging; CN - ; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSD - Dangerous Substance Directive; DSL - Domestic Substances List; EC – European Commission; EEC - European Economic Community; EIN - European Inventory of (Existing Commercial Chemical Substances); EINECS - European Inventory of Existing Commercial Chemical Substances; ENCS - Existing and New Chemical Substance Inventory; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; F - Background (for Venezuela Biological Exposure Indices); IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; ISHL - Japan Industrial Safety and Health Law; IUCLID - International Uniform Chemical Information Database; JP - Japan; Kow - Octanol/water partition coefficient; KR KECI Annex 1 - Korea Existing Chemicals Inventory (KECI) / Korea Existing Chemicals List (KECL); KR KECI Annex 2 - Korea Existing Chemicals Inventory (KECI) / Korea Existing Chemicals List (KECL) , KR - Korea; LD50/LC50 - Lethal Dose/ Lethal Concentration; KR REACH CCA - Korea Registration and Evaluation of Chemical Substances Chemical Control Act; LEL - Lower Explosive Limit; LLV - Level Limit Value; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; MX – Mexico; Ne- Non-specific; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; Nq - Non-quantitative; NSL – Non-Domestic Substance List (Canada); NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PEL- Permissible Exposure Limit; PH - Philippines; RCRA - Resource Conservation and Recovery Act; REACH- Registration, Evaluation, Authorisation, and restriction of Chemicals; RID - European Rail Transport; SARA - Superfund Amendments and Reauthorization Act; Sc - Semi-quantitative; STEL - Short-term Exposure Limit; TCCA – Korea Toxic Chemicals Control Act; TDG - Transportation of Dangerous Goods; TH-TECI - Thailand - FDA Existing Chemicals Inventory (TECI); TLV - Threshold Limit Value; TSCA - Toxic Substances Control Act; TW – Taiwan; TWA - Time Weighted Average; UEL - Upper Explosive Limit; UN/NA - United Nations /North American; US - United States; VLE - Exposure Limit Value (Mexico); VN (Draft) - Vietnam (Draft); WHMIS - Workplace Hazardous Materials Information System (Canada). Other Information Disclaimer: The information in this (Material) Safety Data Sheet ("(M)SDS") is believed to be current and accurate as of the time of shipment of the product by Entegris. Entegris makes no warranties, express or implied, with respect to such information, including, without limitation, the implied warranties of merchantability and fitness for a particular purpose. Entegris assumes no liability for any loss or injury which may result from the use of the information contained in this (M)SDS. The chemical, physical and toxicological properties of the Entegris product described in this (M)SDS have not been thoroughly investigated. Users are responsible for exercising due care in using the Entegris product, and for conducting their own investigation to determine whether the product is fit for their particular purpose and suitable for their method of use or application. It is the user's responsibility to ensure that its activities comply with all applicable laws and regulations. Entegris is a registered trademark of Entegris Inc. or an affiliated company. © 2015 Entegris Inc. or affiliated company. All rights reserved.

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