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Annual Report 2016 Raine Medical Research Foundation annual report 2016 annual report 2016 RAINE ANNUAL REPORT 2016 | 1 CONTENTS Chair’s Address 5 Research Committee 8 BrightSpark/Raine Alliance Committee 9 Grants 10 Raine Priming Grants 11 Dr Holly Clifford 15 Environmental dust and the lung: Impact in remote Aboriginal Australian communities Dr Anja Stirnweiss 17 Protein signalling networks in NUT Midline Carcinoma (NMC) Dr Benjamin Mullin 18 Role of genetic copy number variation in osteoporosis Dr Coral-Ann Almeida 20 Stimulation of HIV-specific cytolytic effector function using allogeneic cell immunotherapy Dr Bree Foley 22 Enhancing NK cell mediated anti-tumour responses Dr Sally Lansley 24 The effect of Fibroblast Growth Factor 9 on anti-tumour immunity in malignant mesothelioma Dr Gemma Cadby 26 The association of sleep apnoea and long-term health outcomes in Western Australian adults Dr Tristan Clemons 27 Nanoparticle delivery for the treatment of scarring Dr Elin Gray 29 Genetic Analysis of Circulating Tumour Cells and Circulating Tumour DNA for Prognosis of Uveal Melanoma Dr Grand Roman Joldes 31 Towards translating the benefits of patient specific biomechanics into clinical practice Dr Alison McDonnell 33 Identifying immune biomarkers of response to chemotherapy in thoracic cancers 2 | RAINE ANNUAL REPORT 2016 Fellowships 34 WA Department of Health/Raine Clinician Research Fellowships 35 Clinical Associate Professor Gareth Baynam 40 1 in 12: Translational Research for Rare Diseases Dr Christopher Blyth 43 Preventing influenza morbidity and mortality in West Australian children through vaccination Dr Aron Chakera 45 The influence of multistrain cytomegalovirus infections on the immune repertoire: Implications for organ transplantation Clinical Professor Tomas Corcoran 48 Project 1: REstrictive versus LIbEral Fluid Therapy in Major Abdominal Surgery (RELIEF study) Project 2: The influence of anaesthetic depth on patient outcome after major surgery (BALANCED study) Dr Hugh Davies 49 The F.L.U.I.D. study (Forecasting Level of Ultrafiltration and Intensity of Dialysis) Dr Dale Edgar 52 Does exercise training improve muscle strength and function after burn injury? Dr Edward Fysh 54 Pleural Effusions in Intensive Care Patients: The Physiological Changes and Clinical Effects of Drainage Procedures Clinical Associate Professor Kwok-ming Ho 56 Detailed assessment of risks and benefits of inferior vena cava filters on patients with complicated injuries (the da Vinci Trial) Dr Annette Lim 59 Mechanisms that facilitate the metastatic potential of oral cancer Dr André Schultz 60 The airway surface liquid micro environment in children with cystic fibrosis Dr Ulrich Steinwandel 62 Do ultrasound measurements of the inferior vena cava (IVC-US) by nursing staff improve assessment of intravascular volume status in the satellite haemodialysis clinic settings? Dr Brigitte Tampin 64 The role of sensory parameters in predicting clinical outcome after lumbar discectomy RAINE ANNUAL REPORT 2016 | 3 Awards 66 Raine Visiting Professor Awards 67 Professor Raffaele Dellacà 67 Professor Gao Xiang 68 Professor Stephen Hill 68 Professor Shulamit Levenberg 69 Professor Ro Osawa 69 Professor Gijs van Soest 70 Professor José Luis Gómez-Skarmeta 71 BrightSpark Research Collaboration Awards 72 Cockell Research Collaboration Awards 73 Professor David Bruce 76 Neuroinflammation in type 2 diabetes: A PET study using the novel radioligand, [18F]-FEPPA Dr Jennifer Rodger 77 Preclinical optimisation of repetitive transcranial magnetic stimulation for youth with treatment-refractory depression Professor Sergio Starkstein 79 Autism Spectrum Disorder in middle to late adulthood: Phenomenology, behavioural correlates and societal costs Assistant Professor Anna Waterreus 80 Simple Physical Activity Questionnaire (SIMPAQ): an international validation study Prizes 82 Raine Research Prize 83 Dr Helena Viola Strachan Memorial Prize 84 Dr Rishi Kotecha Publications 85 The Raine Study 89 Raine Annual Awards Ceremony 95 Financial Report 96 4 | RAINE ANNUAL REPORT 2016 Chair’s Address Similarly, the excellent partnership between BrightSpark and Raine is now firmly consolidated into one outstanding Alliance as it works diligently to support young rising stars who, in turn, are breaking barriers in their quest to find answers to childhood disease and improve the lives of sick children. I am also delighted to report that the Jon and Caro Stewart Family Foundation has made a generous donation over two years in support of the top Raine Priming Grant project in child health research. The Grant was awarded to an outstanding young scientist, Dr Melissa O’Donnell, which carries the name Stewart/BrightSpark/Raine Grant for her project entitled: Alcohol-related harm in young people: Developing a longitudinal evidence base. The Raine Foundation is mindful that the development of collaborative partnerships for our young scientists is now more important than ever, not only for the dissemination and sharing of knowledge, but also for the advancement of science to improve the well-being of everyday life of those suffering illness and disease. The Raine Foundation manages two successful Research Collaboration Award As Chair of the Research Committee, it gives me programs: the first funded by the Edith E Cockell Bequest great pleasure to report that 2016 was another highly is directed toward research into mental health illness, successful and productive year for the Raine Medical and the second, funded by the BrightSpark Foundation, Research Foundation. is in support of research into childhood illness. Since 2015, a total of 12 Research Collaboration Awards have The Foundation continued to fulfil its principal goal of been allocated with total funds in excess of $130,000. supporting the brightest and best young medical research These Awards give scientists the opportunity to develop minds in Western Australia with overall funding in excess of links with their national and international counterparts, $2 million. Congratulations go to the 27 recipients who were advance their research strengths and facilitate visits to awarded a Project Grant, a Clinician Research Fellowship, academic institutions that, hopefully, will lead to long-term a Collaboration Award, or Publication Prize. This excellent partnerships. The ultimate goal, however, is to advance result was achieved in association with our partners, the medical knowledge into the cause and treatment of WA Department of Health and the BrightSpark Foundation, illness and disease. who share the philosophy of the Raine Foundation and are similarly committed to encouraging and nurturing the career Distinguished scientists visiting WA universities continue of young medical research scientists. It is further rewarding to enrich and advance our medical research knowledge to know that this level of research and funding promises and expand our collaborative global network under the to provide the wider community with improved clinical Raine Visiting Professorship scheme. We were privileged practices and better health outcomes. to welcome six outstanding scientists from some of the top international Universities, including Nanjing, Kobe, the The development of the Clinical Research Fellowship Erasmus University Medical Center and the Israel Institute Program, initiated in 2012 by the Department of Health, of Technology. These Visiting Professors, each a leader in continues to be a resounding success. Since its their field of expertise, were generous with their knowledge establishment, twenty-one Fellowships have been awarded and time, and were excited to develop new collaborative in support of top clinical research projects with combined networks with our WA scientists. It was particularly pleasing funding of $5.3m. And now, four years since those first to note that the Raine Lectures were well attended, four Fellowships were awarded, we are able to see how the attracting a wide-ranging audience that included scientists determination and commitment of these young clinicians is from cross-disciplinary fields and often from various making a real impact on the development of health policy academic and research institutions. It is clear that the and planning, along with changes to clinical practice. Raine Visiting Professorship scheme is a major and valued The Reports commencing on page 40 demonstrate how resource among the local research community and one that these innovative programs are improving the lives of those the Raine Foundation is pleased to endorse. Full details of suffering ill health. the 2016 Raine Visiting Professors is on page 67. RAINE ANNUAL REPORT 2016 | 5 It also gives me great pleasure to welcome Mr Garry Prendiville to the Raine Board as our Financial Consultant. A UWA graduate in Engineering and Commerce, Mr Prendiville brings to Raine and Healy a wealth of corporate knowledge and financial expertise from his many years as a successful businessman and former President of the Motor Trade Association of Western Australia. Mr Prendiville is also centrally involved in a diverse group of successful family companies operating in wine, petroleum, hospitality and tourism industries. Professor Robert McLaughlin The importance that Raine places on seeding money and the power of innovative research to translate into clinical outcomes was recently displayed in the outstanding success of one of our earlier Priming Grant recipients, Professor Robert McLaughlin. In 2007 Raine was pleased to award one of its largest Priming Grants to Dr McLaughlin to facilitate
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