ANNUAL REPORT 2019 Raine Medical Research Foundation CONTENTS
“It is true to say that, if not today ABOUT THE FOUNDATION 4 or even tomorrow, certainly at some CHAIR’S REPORT 5 time in the future, each and every DIRECTOR’S REPORT 6 West Australian will benefit in some IN MEMORY OF MEG SANGSTER 6 way from the generous legacy Mary RESEARCH FUNDING 7 Raine left to this State.” ANNUAL AWARDS CEREMONY 22 OUR PEOPLE 23 Meg Sangster, The Mary Raine Story FINANCIAL REPORTS 25
OUR PARTNERS AND DONORS
Our thanks go to our generous donors and partners who have contributed to the outstanding research programs supported in 2019. This ongoing support has enabled the expansion of our programs and increased funding for leading research in WA.
COCKELL BEQUEST
Government of Western Australia Department of Health
RIGBY FAMILY STRACHAN BEQUEST BEQUEST ABOUT THE FOUNDATION CHAIR’S REPORT
The Raine Medical She was a visionary and saw the establishment of the Raine Foundation It is with great pleasure that I present to • Raine/Robson Fellow – This title was Research Foundation is as a unique opportunity for her life’s work to live on in perpetuity – to grow you the 2019 Annual Report of the Raine awarded to the top applicant, Dr Lucy an outstanding example and develop into something more important and more valuable than the Medical Research Foundation, including Furfaro from the UWA Division of of what can be achieved business success and wealth that she had personally achieved. She did this the activities of the Healy Medical Obstetrics and Gynaecology, for her when a generous act of by giving scientists and clinicians the means and opportunity to embark on Research Foundation. research investigating the implications philanthropy is directed medical research and to seek answers to questions that were not known in of bacteriophage exposure on maternal toward improving the lives her lifetime. FUNDING DISTRIBUTIONS health and disease. • Publication Prizes – These Prizes of others. This was Mary It has been another strong year of medical • Raine/BrightSpark Fellow – Dr Emma are awarded for the best published Raine’s wish when in 1957 Today, the Raine Foundation has allocated $50mill towards medical research support for the Raine Foundation. De Jong from the Telethon Kids Institute research by an early-career researcher she made the decision research in support of numerous competitive funding programs including The Foundation distributed $2,410,058 was awarded this title for her research in and facilitate conference travel and to leave her wealth to two Centres of Excellence, project grants, fellowships, scholarships, towards WA medical research, including 48 the area of child health looking at using research collaboration. Two Awards were The University of Western Australia for the establishment of a collaboration awards, visiting professor awards, and publication prizes. ongoing projects that resulted in 56 research immune memory responses to predict granted for travel in 2020 at the value of medical research foundation. The Raine Foundation has partnered with many generous donors and articles being published in 2019. We were asthma disease trajectories. $5,000 each. organisations in continued efforts to retain and provide ongoing support honoured to welcome distinguished scientists • Raine/Cockell Fellow – This title was • Raine Visiting Professor Awards – This Mary Raine’s story is inspirational. Her humble beginnings were an for future generations of scientists in Western Australia, whose health from the UK, USA, Germany, Melbourne and awarded to Dr Rebecca Bennett from program was established in 1971 and unlikely launching pad for the success and wealth she came to achieve discoveries will benefit all in the community. Sydney for visits with our researchers, as the Ear Science Institute Australia for her facilitates the visits of distinguished in her lifetime. Through hard work and the application of business acumen part of the Raine Visiting Professors program. research in the area of mental illness, scientists to Western Australia to impart rarely seen in a woman in the early years of the 20th century, Mary Raine went (Top Left: Mary Raine in 1957 (photo courtesy The West Australian). We also continued our support for the concentrating on helping adults with their vast knowledge and expertise. Six on to build a large real estate empire. Raine Study, which celebrated its 30 year hearing loss manage their mental health. Raine Visiting Professor Awards were anniversary since the Raine Foundation funded for future visits, with a total funding provided initial support to start this Clinician Research Fellowship program allocation of $38,872, and accommodation internationally acclaimed longitudinal study. This program was established through a provided by the Forrest Research partnership with the WA Department of Health Foundation at Forrest Hall. The supported OUR MISSION ENDURING PARTNERSHIPS and aims to support high achieving clinicians, Professors hail from the UK, USA, China, Over 50% of the funding distributed by the allied health professionals and nurses, to New Zealand and Canada. Mary Raine was explicit in her wishes as documented in the Raine Foundation Deed of Trust (1957) that: “The Raine Foundation in 2019 was committed facilitate their early research careers for the net income of the Fund shall be applied towards seeking, diagnosing and investigating the nature, origin and by our generous partners and donors who advancement of medical research outcomes GRANT REVIEW AND COMMITTEES causes of diseases in human beings, with the initial emphasis on arteriosclerosis and allied diseases, and the strongly align with Mary Raine’s vision and translation in the clinical setting. This The Raine Management Office works hard of achieving better health outcomes for program continues to be a great success, with to continuously improve our grant review prevention, cure, alleviation and combating of such diseases.” the community. Our major partners and 33 Clinician Research Fellowships supported processes to align with international best supporters in 2019 were the WA State since 2012 and a total funding commitment practice, and to minimise redundancy in Government Department of Health, of over $8.7mill. Three new Fellowships were application forms. This is strengthened The University of Western Australia, the awarded for Round 8 to commence in 2020, by the knowledge and expertise of our BrightSpark Foundation, the Jon and Caro with a total funding allocation of $946,207. committee and advisory panel members, OUR CORE VALUES Stewart Family Foundation, the Charter Hall and the hundreds of top international and Group, the Forrest Research Foundation, and Awards & Prizes programs national researchers we contact each year the Rigby Family. We are incredibly grateful Facilitating collaboration between key leaders to review our applications. They are all for their continued support. and our WA researchers has always been volunteers, who give their time to ensure a strong focus for the Foundation for the that we only invest in the very best research NEWLY AWARDED FUNDING development of international quality research in WA. We have enormous gratitude for the This year we consolidated our main funding in the state. All of our Awards & Prizes commitment and passion of Dr Richard areas into five priority programs that continue programs align with this objective. Choong, who served as the Australian Medical to support research excellence and the Association representative on the Raine and development of medical research leadership • Research Collaboration Awards – These Healy Research Committees for six years and We strive to ensure We continuously We facilitate We support the early in Western Australia. awards aim to encourage medical stood down at the end of 2019. The strong research excellence by develop and uphold collaborative careers of our future researchers in Western Australia to leadership and guidance provided by these supporting outstanding robust, transparent, and activities that allow research leaders, to Raine Priming Grant program establish and develop national and volunteers has strengthened our reputation medical research equitable grant review our researchers ensure the growth We have now distributed nearly $30 million international collaborative research and commitment to medical research in WA. scientists and programs processes to ensure to work and learn of a strong research GROWTH towards this program, with a proud history of activities. Six Awards were granted
that will improve health INTEGRITY that only the very best from internationally community that strives supporting the research and careers of WA’s across three different partnership
EXCELLENCE outcomes. research is supported. recognised research for real-world impact. best early-career medical researchers. Seven categories, spanning early career leaders. grants were awarded to commence in 2020, researchers, child health and mental with a total funding pool of $1,178,861. illness, with a total funding pool PROFESSOR ROBYN OWENS COLLABORATION of $142,653. Chair
4 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 5 DIRECTOR’S REPORT RESEARCH FUNDING
This year, the Raine who also recognise the need to maintain the feasibility and quality of RAINE PRIMING GRANTS AWARDED IN 2019 Foundation has expanded supported research and the increasing costs for research. capacity and efficiency in Building the next generation of research leaders our systems and programs In 2020, we plan to progress strategic review activities to chart a path for so that we can best support growth and impact through increased engagement with key stakeholders This program supports early-career researchers to develop research independence and leadership, while building their the research community. such as alumni, partners and the wider community. A new website is skills and track record so that they are competitive for national and international funding. This included consolidation of our planned which will be more user friendly and will feature our research funding programs to streamline stories and impact. We will also start an evaluation program that tracks NUMBER OF Number shortlisted research impact and career progression of the 500+ alumni and projects application and review processes, for external review: AMOUNT $ and inclusion of research we have supported over the last 60 years. This is all possible due to the APPLICATIONS: impact pathway questions in enormous support provided by our committees and advisory panel AWARDED: our programs to encourage these thought processes across the project members, who have volunteered their time and expertise. My thanks also lifecycle. This aligns with developments in the international and national go to my new Raine Management Office team, who provide a constant 7SUCCESSFUL $1,178,861 medical research landscape and provides a more thorough process for source of great ideas and commitment to the Foundations cause. 35 (20% success rate) assessing and communicating research impact. 14
A review of the funding available for our existing programs highlighted the DR RYAN ANDERTON DR REBECCA BENNETT need to maintain relevance and to increase support where possible. This School of Health Sciences, University of (Raine/Cockell Fellow) resulted in an increase in total funding that each applicant could apply for Notre Dame Australia, Perron Institute for Clinical Research, Ear Science Institute in some of our larger programs, and an increase in the total funding pool. Neurological and Translational Sciences Australia DR AMANDA CLEAVER, DIRECTOR This was accompanied by an increase in commitment from our partners, Investigating a novel class of Helping adults with hearing loss peptide as a therapeutic for manage their mental health neurodegenerative disorders $179,423 $174,902
IN MEMORY OF MEG SANGSTER DR LUCY FURFARO DR EMMA DE JONG (Raine/Robson Fellow) (Raine/BrightSpark Fellow) Division of Obstetrics and Gynaecology, Telethon Kids Institute, The University of (1922-2019) The University of Western Australia Western Australia Bacteriophage exposure in utero: Predicting asthma disease The Raine Foundation is forever grateful for the Meg will forever be remembered as a strong and passionate supporter of Implications for health and disease trajectories through systems-level extraordinary mind of Meg Sangster and her passion for the Raine Medical Research Foundation in upholding Mary Raine’s vision of $246,407 analyses of immune memory relaying the life and achievements of Mary Raine. finding cures for human disease. $215,000
Meg and her late husband, Eric (Cole) Sangster became close friends with Mary and Joe Raine when they moved to WA from NSW in 1948. Mary DR AVENI HAYNES DR LAKSHINI HERAT Child Health Research, Telethon Kids School of Biomedical Sciences and Dobney Raine was an astute businesswoman who owned a large portfolio of Institute Hypertension Centre, The University of property and hotels, including the Wentworth and Windsor Hotels. Meg Western Australia and Cole initially stayed at the Wentworth Hotel when they arrived in WA, Informing T1D prevention which was then managed by, and home to, Mary and Joe Raine. They strategies by identifying early A novel role for sodium glucose soon became close friends and in 1949 Mary and Joe asked Meg and Cole dysglycaemia in children at risk co-transporter 2 in diabetic to manage the Windsor Hotel. This was an overwhelming but exciting $69,625 retinopathy and nephropathy offer for the young couple who soon accepted the challenge and later the $99,865 leasehold of the Hotel. DR ALEXANDER TANG Meg and Cole were instrumental in turning business around for the School of Biological Sciences, The University Windsor Hotel and soon introduced the concept of the beer garden and of Western Australia jugs of beer to WA. Meg authored and published “The Mary Raine Story – Harnessing neuroplasticity in the From Putney to Perth” in 2001, recounting the extraordinary life and times young and old brain with brain of Mary Raine, and Meg’s personal journey as an unexpected but hugely stimulation successful hotelier in WA. $193,639
6 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 7 RAINE PRIMING GRANT RAINE PRIMING GRANT CSANZ 66th Annual Scientific Meeting. Dr Jim The Telethon Kids Youth Mental Health Team Bell, Dr Helena Viola, Professor Livia Hool
Telethon Kids Institute, $ School of Human Sciences, $ The University of Western Australia Duration: 2017 – 2019 $150,000 The University of Western Australia Duration: 2017 – 2019 $150,000
DR ASHLEIGH LIN DR HELENA VIOLA Understanding the physical and mental health outcomes of gender Identification of a preventative treatment for the leading cause affirming intervention of sudden cardiac death in the young (GENTLE: The GENder identiTy Longitudinal Experience Project) (A novel approach for the prevention of hypertrophic cardiomyopathy)
the lifespan of people who have accessed students and 10 interns have also contributed cardiomyopathy (thickening of the heart Science Advances, as well as a patent hormonal gender affirming intervention in to the project to date, thereby supporting the muscle), which is the leading cause of sudden pending for the identified drug treatment. adolescence through the development of the career development of the next generation of cardiac death in the young. There is currently Since commencing the Raine Priming Grant, GENTLE cohort. early-career researchers. no treatment available to prevent this disease. Dr Viola has been successful in obtaining additional national grant funding (Heart The GENTLE cohort is made up of all clients At the conclusion of this Raine Priming Grant, Over the course of her research career, Foundation & NHMRC). This has assisted her at the Gender Diversity Service at the Perth there were 165 young people in the GENTLE Dr Viola has identified that a calcium to further investigate the potential treatment Children’s Hospital in WA who consent to their cohort and the cohort continues to grow. channel in the membrane of heart cells effects of the identified drug on decreasing mental and physical health data being used The project has obtained additional funding, regulates heart metabolism, and that the extracellular matrix stiffness (associated with for research purposes. There have been three building the cohort further with the aim to activity of this calcium channel is impaired in the cardiomyopathic heart) and preventing publications from the study on the impact continue to assess and support the physical hypertrophic cardiomyopathy. sudden cardiac death. of hormones on the physical and mental and mental health of adolescents seeking health of trans and gender diverse children gender affirming intervention. This research has discovered a new early- “I am extraordinarily grateful to have Associate Professor Ashleigh Lin is an NHMRC and adolescents. One finding is that there is intervention approach to prevent hypertrophic received funding from the Raine Career Development Fellow and Program Head a relatively high occurrence of autism traits in Dr Helena Viola is a Heart Foundation Future cardiomyopathy by normalising heart Medical Research Foundation and of the Mental Health and Youth team at the the young people who are part of the GENTLE Leader Fellow in the School of Human metabolism using a drug that targets this the possibilities that have resulted. It Telethon Kids Institute. cohort and that those individuals with autism Sciences at The University of Western Australia. calcium channel. Once translated this will traits have poorer mental health. She completed her PhD with Distinction in significantly decrease associated morbidity has enabled me to produce critical She received her Master of Clinical Researchers have also developed a group 2010, being awarded the UWA Robert Street and mortality. preliminary data for two major funding Neuropsychology and PhD in 2011 from The intervention program, Transforming Families, Prize for most outstanding PhD thesis across applications, including a NHMRC New University of Melbourne. Associate Professor Lin for parents and carers of adolescents in all disciplines. Dr Viola commenced her Raine The findings from this study have led to Investigator Grant, and a National Heart commenced her Raine Priming Grant in 2017 the GENTLE cohort to assist them in better Priming Grant in 2017 to identify a novel, 10 publications in highly rated journals, Foundation Future Leader Fellowship. to investigate health and wellbeing through supporting their child. Five higher education early-intervention therapy for hypertrophic including Nature Communications and I was delighted to be awarded both.”
8 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 9 CLINICIAN RESEARCH FELLOWSHIPS (ROUND 8) AWARDED IN 2019 Enabling clinicians to improve health care through medical research
This program enables clinicians, nurses and allied health professionals to establish a research career while still maintaining their clinical role, seeking to broaden their impact on Western Australian health outcomes and support rapid research translation to clinical practice.
NUMBER OF Number shortlisted AMOUNT APPLICATIONS: for external review: $ AWARDED: CLINICIAN RESEARCH 4SUCCESSFUL FELLOWSHIP 17 5 (23.5% success rate, 1 later declined) $946,207 Sir Charles Gairdner Hospital Duration: 2017 – 2020 $ $429,400 DR MARY ABRAHAM DR EMMA HAMILTON Perth Children’s Hospital Fiona Stanley Hospital Hybrid closed loop system in Improving outcomes for patients adolescents with sub-optimal with diabetes-related foot disease CLINICAL PROFESSOR WAI LIM glycaemic control $403,809 $344,264 Improving health outcomes of kidney transplant recipients (Increased understanding of the immunological risk profile for kidney transplant patients and better long-term health outcomes)
disease, and other blood vessel complications trainees, disseminating study findings are relatively common for chronic kidney at national and international meetings, DR DAYSE TAVORA-VIEIRA “This fellowship has not only helped disease and kidney transplant patients. establishing collaborations and obtaining Fiona Stanley Hospital me generate multiple publications, Therefore, improving ways to identify those additional competitive funding, and has The use of electrophysiology to establish collaborations and at risk and to discover novel agents that may enhanced the standing of Western Australia optimise hearing implants in success in competitive grant be effective in reducing these complications as a quality hub for research activities. The hearing-impaired recipients funding, it has enabled me to are essential to improve the long-term health findings generated from this fellowship have $198,134 provide a greater engagement outcomes and quality of life of people with contributed to changes in health policy and and mentorship of future clinician- chronic kidney disease. improved clinical decision-making processes scientist and researchers, which are in patient management. critical in ensuring the continuity The studies undertaken during this fellowship of clinically-relevant and quality have shown that alternative allocation policies Clinical Professor Lim is grateful to the WA that match the life expectancy of donor kidneys Department of Health and the Raine Medical research going forward” Clinical Professor Wai Lim is a Consultant with the patients could potentially increase the Research Foundation for the financial support Clinical Professor Wai Lim Nephrologist at Sir Charles Gairdner Hospital availability of donor kidneys to disadvantaged offered through the Fellowship, which has and Past Chair of the Western Australia groups and increase the survival of people allowed the expansion of his research activities, Kidney Transplant Service. He was awarded a with chronic kidney disease. Additionally, a enhanced collaboration with researchers globally, Clinician Research Fellowship to elucidate the greater understanding of the immunological risk and assisted the advancement of knowledge with mechanisms underlying renal injury and disease profile for kidney transplant patients and the the ultimate goal of improving health outcomes recurrence in kidney transplant recipients and identification of novel risk factors and potential of kidney transplant recipients and people with to develop an alternative allocation system for interventions for cardiac disease may help to chronic kidney disease. available donor kidneys in Australia to maximise improve the long-term health outcomes of successful transplantation rates and longevity. people with chronic kidney disease. Chronic kidney disease is a highly prevalent non-communicable health problem in Western This fellowship has been successful in Australia and globally is associated with generating multiple publications (over 60 substantial loss of productivity. Health-related since 2017), providing support/supervision complications, including rejection, heart for higher degree students and advanced
10 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 11 RESEARCH COLLABORATION AWARDS AWARDED IN 2019
Connecting emerging and established research leaders across the globe
This program facilitates the development of new collaborations and projects with national and international partners, supporting skill development and knowledge transfer.
NUMBER OF APPLICATIONS: AMOUNT $ AWARDED: 6SUCCESSFUL 12 (50% success rate) $142,653
CLINICIAN RESEARCH FELLOWSHIP 2019 PROTECT investigator meeting DR OLIVIER CLEMENT DR LAURA DONDZILO (Cockell Research Collaboration Award) (Cockell Research Collaboration Award) Harry Perkins Institute of Medical Research, The University of Western Australia with the King Edward Memorial Duration: 2017 – 2020 $ $412,154 The University of Western Australia with University of Münster, Germany Hospital Trinity College, Dublin Efficacy of a novel self-appraisal Unravelling the (epi)genomic induction in Body Dysmorphic regulatory mechanisms governing Disorder CLINICAL PROFESSOR TOBIAS STRUNK memory to understand cognitive $18,500 decline in aging Improving survival rates and reducing disability in preterm infants $19,590
(Can Pentoxifylline improve survival without disability in preterm infants with late-onset sepsis or necrotizing enterocolitis – a pragmatic randomised controlled trial?) DR JULIE JI DR NICOLA BONDONNO Survival of preterm infants has improved co-infused in neonatal intensive care, providing (Cockell Research Collaboration Award) (Healy Research Collaboration Award) dramatically over the past decades, but these the most complete and systematic assessment The University of Western Australia with Edith Cowan University with The University vulnerable infants still account for most of to date and resulting in several publications Uppsala University, Sweden of Western Australia and Gentofte Hospital, neonatal illness and long-term complications. on this topic. The research findings have been Investigating “flashforward” mental Denmark Bloodstream infections (sepsis) and gut injury applied clinically through their addition to the imagery of self-injury as a proximal Investigating the relationship (necrotising enterocolitits) are common serious KEMH medication compatibility chart, which risk barometer and modifiable between dietary components and complications of preterm birth and may lead is hosted on the KEMH website and accessed treatment target cardiometabolic disease to life-long disability. In this trial, the research daily by Neonatal Units nationally. $16,456 $29,722.51 team is investigating whether Pentoxifylline, when given in addition to routine care in Professor Strunk is grateful to the WA infants with suspected bloodstream infection Department of Health and the Raine Medical or gut injury, can improve survival into Research Foundation for the ability to have DR GIZACHEW TESSEMA DR AMY FINLAY-JONES childhood without disability. dedicated research time through the Fellowship. (Charter Hall Research Collaboration Award) (BrightSpark Research Collaboration Award) Clinical Professor Tobias Strunk is a Consultant This has allowed significantly increased research Curtin University with the Norwegian Telethon Kids Institute, The University of Neonatologist with the Neonatal Intensive Working with international collaborators in outputs, with 30 new publications since 2017, Institute of Public Health Western Australia with the University of Care Unit at King Edward Memorial Hospital for Singapore, Taiwan, Canada and Ireland, this and led to additional grant applications for Adverse birth outcomes and California, USA Women (KEMH). randomised control trial will include 1800 national funding. Professor Strunk will continue interpregnancy interval in Beyond Brain and Behaviour: preterm infants with a clinical presentation of to work on achieving the aims of this highly Australia and Norway: A new Understanding the role of the gut He was awarded a Clinician Research late-onset sepsis or necrotizing enterocolitis. relevant project, with the potential for the international collaboration on the microbiome in infant and child Fellowship to investigate whether an anti- Professor Strunk has also been working in findings of this novel treatment approach to be influence of pregnancy loss mental health inflammatory, safe medication called close collaboration with KEMH pharmacists rapidly translated into routine clinical practice. $28,951 $29,433.42 Pentoxifylline has the potential to increase and Curtin University to establish extensive survival without disability in babies born very testing for physical compatibility of early (more than 3 months early). intravenous medications that are commonly
12 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 13 COCKELL RESEARCH COLLABORATION HEALY RESEARCH AWARD COLLABORATION AWARD
Children’s Diabetes Centre, Telethon Kids Institute School of Molecular Sciences, in collaboration with the Interdisciplinary Center Psychopathology and $ The University of Western Australia $ Emotion Regulation (ICPE), Department of Psychiatry, University Medical Duration: 2019 $14,911.80 in collaboration with the University of California (Los Angeles) Duration: 2018 – 2019 $10,000 Centre of Groningen, Netherlands and the National Physical Laboratory (London)
DR KEELY BEBBINGTON DR HAIBO JIANG Increased stress precedes increased blood glucose levels in adolescents Novel methods to understand cholesterol balance with Type 1 Diabetes (Characterising development of a multimodal mass spectrometry imaging platform for lipid analysis) (Characterising moment-to-moment fluctuation in stress, anxiety and blood glucose levels in children and adolescents with Type 1 Diabetes) and dynamics are limited. In this collaborative ongoing collaborations as a result of this project, project, bringing together a world leading which has led to an ARC Linkage Project grant glucose levels and diabetes-related behavioural The key findings of this research were that lipid biologist and a leading expert in imaging and another grant application in planning. responses is essential for the development increases in state anxiety precede increases mass spectrometry, the researchers further of effective interventions. However, to date, in sensor glucose levels. There was also developed a novel method that combines research in this area has failed to shed light on considerable variability between individuals different advanced microscopy technologies how stress, anxiety and blood glucose levels in the size of this effect. Additionally, this data to enable better investigation of molecular may vary, moment-to-moment. can reveal individual differences in these trafficking and metabolism. associations which is vital information in the The primary aim of this study was to development of personalised interventions Using this novel method, they discovered investigate changes in stress, anxiety and in this population and will allow further that macrophages release cholesterol-rich blood glucose levels throughout the day investigations of what works, for whom particles from projections on the cell surface. using a novel technique known as experience and in what context. The findings from this This process could be an important way that sampling methodology (ESM) in combination collaborative study are currently in preparation Dr Haibo Jiang is an ARC Discovery Early macrophages release excess cholesterol. with continuous glucose monitoring (CGM) for publication. Career Researcher Award (DECRA) Research Accumulation of excess cholesterol could lead technology. To analyse this complex data, Fellow in the School of Molecular Sciences at to the development of atherosclerosis. Hence, Dr Keely Bebbington is a McCusker Research Dr Bebbington collaborated with experts in These findings were presented at the American The University of Western Australia. Dr Jiang’s the release of cholesterol-rich particles could Fellow working on Type 1 Diabetes (T1D) at the the use of this methodology, based at The Diabetes Association Scientific Sessions in San research is largely focused on the development be an important mechanism that macrophages Telethon Kids Institute. Interdisciplinary Center for Psychopathology Francisco in June 2019. At these sessions, Dr of novel technologies to investigate molecular use to maintain cholesterol balance, which is and Emotion Regulation in Groningen, Bebbington was able to connect with experts in In this collaboration, Dr Jiang and his team trafficking and metabolism and its impact critical for human health. These collaborative It is now well documented that children and Netherlands. During an 11 day visit to the area of mental health and Type 1 Diabetes, discovered that macrophages release on human health. While abnormalities in activities and studies have resulted in two cholesterol-rich particles (red) from filopodia adolescents with Type 1 Diabetes are at greater Groningen, the researchers explored novel laying the groundwork for future collaborations. lipid metabolism can lead to major health peer-reviewed publications and multiple (grey). risk for psychological disorders than young statistical approaches to the analysis of this conditions such as cardiovascular disease, presentations across the world, including invited people without diabetes. Understanding the time-series data. analytical tools to study lipid distributions talks at conferences. Dr Jiang has established interplay between stress and anxiety, blood
14 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 15 PUBLICATION PRIZES AWARDED IN 2019 Facilitating dissemination of research knowledge
These Prizes are awarded to early-career scientists who have published high-quality research that has advanced their medical research field. The Prize facilitates conference travel and collaborative research activities.
NUMBER OF AMOUNT $ APPLICATIONS: AWARDED: 2SUCCESSFUL 10 (20% success rate) $10,000
DR RACHAEL ZEMEK DR AVENI HAYNES (Raine Research Prize) (Strachan Memorial Prize) Cancer Centre Children’s Diabetes Centre STRACHAN MEMORIAL PRIZE Telethon Kids Institute Telethon Kids Institute Sensitization to immune Decreasing trends in mean HbA1c checkpoint blockade through are not associated with increasing Department of Respiratory Medicine $ activation of a STAT1/NK axis in rates of severe hypoglycaemia in Sir Charles Gairdner Hospital Duration: 2019 $5,000 the tumor microenvironment children: A longitudinal analysis Published in Science Translational of two contemporary population- Medicine based pediatric type 1 diabetes DR RAJESH THOMAS $5,000 registries from Australia and Germany/Austria between 1995 and 2016 New strategies to improve outcomes for lung disease Published in Diabetes Care (Effect of an indwelling pleural catheter vs talc pleurodesis on hospitalization days in patients with malignant pleural effusion: $5,000 The AMPLE randomized clinical trial)
of the American Medical Association (Thomas et received positive feedback from presenters al., JAMA. 2017; 318(19): 1903-1912). and attendees alike, which has led to a number of potential future collaborators for his Dr Thomas’ research aims to identify treatment ongoing research. and management strategies for malignant pleural effusions to reduce hospitalisation In November 2019, he presented as an invited stay times, relieve breathlessness and provide speaker at the Joint National Conference freedom for physical activity for patients with of Indian Chest Society & National Colleges the disease. of Chest Physicians in Kochi, India. He also presented at two conferences held in the The Strachan Memorial Prize assisted Dr Gold Coast in early 2019; the Thoracic Society Thomas to attend multiple national and of Australia & New Zealand Conference and international conferences. In October 2019, the Asia-Pacific Congress on Bronchology, The 2019 recipient of the Strachan Memorial he attended the American College of Chest in early 2019. His presentations at these four Prize was Dr Rajesh Thomas from the Physicians CHEST Conference in New Orleans, conferences in 2019 has led to invitations Department of Respiratory Medicine, Sir USA, the world’s largest clinical chest medicine to speak at upcoming international Charles Gairdner Hospital, for his article entitled event. During this conference, Dr Thomas conferences in 2020. “Effect of an indwelling pleural catheter vs talc presented and chaired three sessions, where pleurodesis on hospitalization days in patients he shared the stage with several world leaders Since receiving the Strachan Research Prize, with malignant pleural effusion: The AMPLE and key opinion makers in pleural medicine. Dr Thomas has co-authored nine further randomized clinical trial” published in Journal These sessions were well attended and he publications in the field.
16 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 17 VISITING PROFESSOR AWARDS AWARDED IN 2019
Connecting the best international medical researchers with WA
This program facilitates the visits of national and international distinguished research scholars to Western Australia to share their knowledge and skills through collaborative research projects, workshops, lectures, training and mentoring.
NUMBER OF APPLICATIONS: AMOUNT $ AWARDED: RAINE VISITING 6SUCCESSFUL PROFESSOR AWARD 7 (86% success rate) $38,872 University of Sydney, Australia $ Host: Dr Elin Gray, Edith Cowan Visit: 19 March 2019 – 19 April 2019 $3,790 University PROFESSOR WICKLIFFE ABRAHAM PROFESSOR DAVID ARMSTRONG University of Otago, New Zealand Keck School of Medicine, University of Southern Host: Dr Alexander Tang California, USA Perron Institute for Neurological and Host: Mr Olufemi Oshin PROFESSOR DES RICHARDSON Translational Science, The University of Curtin University Western Australia $7,100 Overcoming treatment resistant cancers $2,555.50 (Raine Lecture: From bench-to-bedside: Novel anti-cancer agents that overcome the triad of death – metastasis, resistance and tumour growth)
Professor Richardson has published more careers in research, grant writing and potential than 400 articles, reviews, books and patents, collaborative opportunities. made over 560 presentations, is a member PROFESSOR ORNIT CHIBA-FALECK PROFESSOR CHRIS HAMMOND of 43 Journal Editorial Boards, and has been As a result of discussions during his visit and Department of Neurology, Duke University, USA King’s College London, UK awarded 293 competitive grants, including collaboration, an Edith Cowan University Host: Professor Patrick Akkari Host: Professor David Mackey 68 NHMRC Grants/Fellowships. He has PhD student secured a university grant to Perron Institute for Neurological and Lions Eye Institute, The University of supervised more than 100 higher education visit and work in Professor Richardson’s Translational Science Western Australia students and is a triple prize-winning mentor, lab at the University of Sydney. Further $5,000 $5,400 being recognised both locally (USYD Vice- collaborative projects are also in development, Chancellor’s Award for Excellence in Research including co-supervision of PhD students and Higher Degree Supervision) and internationally. grants applications.
Professor Richardson was invited as a Raine Professor Des Richardson is a NHMRC Visiting Professor by Dr Elin Gray from the PROFESSOR MICHAEL RIDDELL PROFESSOR ERWEI SONG Principal Research Fellow and Director of School of Medical and Health Sciences at Edith York University, Canada Sun Yat-Sen Memorial Hospital, Sun Yat-Sen the Molecular Pharmacology and Pathology Cowan University (ECU), with the objective Host: Professor Elizabeth Davis University, China program at The University of Sydney. A multi- of establishing collaborative activities in Telethon Kids Institute Host: Professor Ruth Ganss disciplinary researcher in drug development understanding mechanisms of melanoma Harry Perkins Institute of Medical $11,400 and translation, Professor Richardson is a growth and overcoming drug resistance. During Research pharmacist, biochemist and cell and molecular Professor Richardson’s visit, he conducted a $7,416.30 biologist. Over the course of his thirty-year lecture titled “From bench-to-bedside: Novel career, he has endeavoured to dissect cancer anti-cancer agents that overcome the triad mechanisms and develop anti-cancer drugs of death – metastasis, resistance and tumour to overcome the three major killers in cancer: growth” as part of the Raine Visiting Professor Metastasis, drug resistance and tumour growth. Lecture series. In addition to this lecture, he Professor Mel Ziman, Professor Des Richardson and Associate Professor Elin Gray. In fact, as a rare achievement in Australia, he delivered presentations to researchers and accomplished bench-to-bedside translation institutions across Perth (including at UWA, of his innovative anti-cancer drug that has Harry Perkins Institute of Medical Research, entered clinical trials for the treatment of and Curtin University), as well as a Master advanced and resistant cancer. Class with early-career researchers to discuss
18 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 19 RAINE VISITING PROFESSOR AWARD
Mayo Clinic, USA $ Host: Associate Professor Jennifer Rodger, The Perron Visit: 28 May 2019 – 5 June 2019 $1,180 Institute for Neurological and Translational Science
PROFESSOR PAUL CROARKIN Latest brain-based interventions for young people with psychiatric disorders (Raine Lecture: Recent innovations and developments in neuromodulation for child and adolescent psychiatric disorders) Neuropsychopharmacology. Dr Croarkin has Institute to share information about science THE RAINE STUDY mentored many students and residents, for careers and pathways in the United States. which he has been recognised with several Furthermore, he consulted with local clinicians Advancing knowledge, enhancing lives honours. He was awarded the 2017 National at Sir Charles Gardiner Hospital to assist Institute of Mental Health Biobehavioral with the development of innovative clinical Research Award for Innovative New Scientists neuromodulation treatments. (NIMH BRAINS). He is a Distinguished Fellow of the American Psychiatric Association. Dr Croarkin’s visit has resulted in a number of The Raine Medical Research Foundation More than Over collaborative initiatives, including submission awarded a major research grant in 1989 for the Dr Croarkin was invited as a Raine Visiting of a co-authored scientific publication, a establishment of the West Australian Pregnancy Professor by Dr Jennifer Rodger from shared grant application, and two further Cohort Study. It was later named “The Raine Study” to acknowledge the original grant from The Perron Institute for Neurological and research projects in development, one 30,000 Translational Science. The aim of his visit was with industry. Additionally, Dr Croarkin the Raine Foundation and its founder Mary pieces of data (and >30 million 500peer reviewed journal Professor Paul Croarkin is Director of the to foster ongoing clinical and translational has extended an invitation for a WA PhD Raine. The Raine Medical Research Foundation pieces of genetic information) articles have been continues to provide funding support for the Mayo Clinic Depression Center with the collaboration focused on healthy youth student to present at the prestigious have been collected on each published on the Raine Raine Study, 30 years on. Department of Psychiatry and Psychology neurodevelopment and novel, brain-based Conference of the American College of Neuro- of the Gen2 participants in the Study resources at the Mayo Clinic, USA. He is a child and interventions for child and adolescent Psychopharmacologists, as well as to visit the The Raine Study aimed to develop a long-term cohort to past 30 years adolescent psychiatrist and neuroscientist with neuropsychiatric disorders. laboratories and clinics at the Mayo Clinic and research the role that early life events (from the womb a research program focused on adapting and University of Minnesota in the USA. onwards) had on later life. From 1989 to 1991, 2,900 innovating brain stimulation interventions for During his visit, Dr Croarkin presented More than In 2019 it was pregnant women (Generation 1) volunteered to be part young people. research seminars at the University of Western of the study. Since the Raine Study was established, the Australia, Telethon Kids Institute, and Fiona children (Generation 2) have been followed up at regular Dr Croarkin’s research has been funded Stanley Hospital, including a lecture titled intervals providing an increasingly rich source of data for by the National Alliance for Research on “Recent innovations and developments in Schizophrenia and Depression, the National local, national and international research. Their families are 30 neuromodulation for child and adolescent also part of the study, with their grandparents (Generation 0) 400babies, Generation 3 (Gen3), Institutes of Health, and Industry partnerships. psychiatric disorders” for the Raine Visiting years and children (Generation 3) now also involved in the study. His findings have been published in numerous Professor Lecture Series. Dr Croarkin was also have been born to the Raine The Raine Study is one of the largest prospective cohorts of since the Raine prestigious journals such as American a guest speaker at a student and early career Study cohort participants Ms Leanne Jiang, Ms Abbey Ford, Professor Paul pregnancy, childhood, adolescence and adulthood to be Study began Journal of Psychiatry, JAMA Psychiatry, and researcher discussion forum at the Perron Croarkin, Associate Professor Jennifer Rodger (estimated to reach 1,500 carried out anywhere in the world. babies within 10 years)
20 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 21 OUR PEOPLE
All members of our Research Committee and Advisory Committees are volunteers. We thank our members for their generosity of time and expertise in ensuring that we support the very best medical research in Western Australia.
RESEARCH COMMITTEE
RAINE ANNUAL AWARDS CEREMONY Each year we celebrate the achievements of our past and present awardees at our breakfast awards ceremony. We were honoured to welcome distinguished guests and alumni, including our guest speakers, Professor Christobel Saunders and Dr Gail Alvares, who spoke about their research and career highlights that came about due to the support of the Raine Foundation. Congratulations go to all of our 2019 awardees. PROFESSOR ROBYN OWENS PROFESSOR ARON PROFESSOR DAVID JOYCE MR PETER SMITH (Chair) CHAKERA Professor of Medicine Fellow, Royal Australasian Deputy Vice-Chancellor (Research) Fellow, Royal Australasian The University of Western Australia College of Surgeons The University of Western Australia College of Physicians
Professor Robyn Owens Ms Jemma Collova, Ms Dielle Horne Professor Tim Colmer, Emeritus Professor Alan Robson, Dr Campbell Thomson
PROFESSOR JEFF DR RICHARD CHOONG PROFESSOR VALERIE MR GARRY PRENDIVILLE HAMDORF General Practitioner, Australian VERHASSELT Financial Consultant Professor of Surgery Medical Association WA branch Professor of Biochemistry Research Committee nominee The University of Western Australia The University of Western Australia
RAINE MANAGEMENT OFFICE
Dr Richard Vaughan, Dr Andrew Miller, Dr Bennie Ng Professor Christobel Saunders Dr Aveni Haynes, Dr Rachel Zemek
DR AMANDA CLEAVER MS NICOLE FEAST MS VICTORIA STEAD-WYNNE Director Senior Research Grants Officer Senior Research Communications Officer Dr Gail Alvares Dr Mary Abraham, Dr Emma Hamilton Professor Elizabeth Davis, Mr Andrew Thompson, Dr Emma de Jong, Dr Amanda Cleaver, Mr Tony Barber
22 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 23 GOVERNANCE STRUCTURE FINANCIAL REPORTS
RAINE & HEALY RESEARCH RAINE MEDICAL RESEARCH FOUNDATION COMMITTEE Financial Summary
INCOME STATEMENT 2019 Income 2019 2018 FINANCE & APPOINTMENT & Income STRATEGIC REVIEW REMUNERATION Investment Income 6,742,066 872,349 COMMITTEE COMMITTEE Donations and Bequests 25,000 17,975 Partnership Funds Received 1,287,525 1,234,658 Management Fees 58,540 56,988 Other Income 103,809 30,397 RAINE PRIMING CLINICIAN RESEARCH AWARDS & PRIZES Total Income 8,216,940 2,212,367 GRANTS ADVISORY FELLOWSHIPS ADVISORY PANEL PANEL ADVISORY PANEL Expenses Medical Research Funding Paid 2,451,938 2,114,917 Employment 225,795 323,482 Administration 34,794 39,420 Investment Income – 82.0% Depreciation 3,106 3,170 Donations and Bequests – 0.3% Other Expenses - 225,088 Partnership Funds Received – 15.7% ADVISORY COMMITTEES Total Expenses 2,715,633 2,480,989 Management Fees – 0.7% Other Income – 1.3% OPERATING SURPLUS / (DEFICIT) 5,501,307 (268,621) FINANCE & APPOINTMENT & RAINE PRIMING CLINICIAN RESEARCH AWARDS & PRIZES STRATEGIC REVIEW REMUNERATION GRANTS ADVISORY FELLOWSHIPS ADVISORY PANEL COMMITTEE COMMITTEE PANEL ADVISORY PANEL INVESTMENT BALANCES 2019 2018 Investments 2019 Expenses Mr Garry Prendiville (Chair) Professor Robyn Owens Associate Professor Steven Mr Darren Gibson (Chair) Professor Robyn Owens Corpus 32,000,028 28,588,800 (Chair) Mutsaers (Chair) (Chair) Mr Geoff Anderson Professor Garry Allison Research Committee Capital 10,895,044 9,052,606 Professor David Joyce Dr Amanda Cleaver Dr Amanda Cleaver Mr Tony Barber Dr Aron Chakera Research Committee Operations 234,483 398,900 (Director) (Director) Mr Garry Prendiville Donations & Bequests 190,610 15,585 Dr Richard Choong Dr Amanda Cleaver Professor Elizabeth Davis Dr Andrew Currie (Director) Total Pool Investments 43,320,165 38,055,891 Dr Amanda Cleaver Dr Archa Fox Professor Gerard Hoyne (Director) Professor Lindy Fitzgerald Professor Brendan Professor David Joyce Other Investments – Market Value Mr Graham Dowland Ms Jodie Hegarty McQuillan 24/95 Monash Avenue (Hollywood) 482,850 482,850 Professor Anna Nowak Mr Peter Smith Professor David Joyce Dexus Property Group (DEXUS) Holdings 2,641,860 2,397,996 Professor Phil Stumbles Professor Andrew Page Mr Andrew Thompson Professor Anne Williams Dexus Property Group (DEXUS) Imputation Credit (Accrual) 4,757 7,207 Professor Valerie Verhasselt Total Other Investment – Market Value 3,129,467 2,888,053 Dr Lisa Wood TOTAL ASSETS 46,449,631 40,943,944 Medical Research Funding Paid – 90.3% Employment – 8.3% Liabilities Administration – 1.3% Provision for leave 26,882 22,108 Depreciation – 0.1% TOTAL LIABILITIES 26,882 22,108
TOTAL NET ASSETS 46,422,749 40,921,836
NB. The Raine Financial Summary is extracted from the full financial statements. The full financial statements of the Raine Medical Research Foundation can be obtained from the Director upon request.
24 Raine Medical Research Foundation – Annual Report 2019 Raine Medical Research Foundation – Annual Report 2019 25 HEALY MEDICAL RESEARCH FOUNDATION Financial Summary
INCOME STATEMENT 2019 Income 2019 2018 Income Investment Income 300,892 25,322 Other Income - 13,857 Total Income 300,892 39,179
Expenses Medical Research Funding 38,856 19,500 Management Fee 8,646 14,223 Total Expenses 47,502 33,723
OPERATING SURPLUS / (DEFICIT) 253,390 5,456 Investment Income – 100% INVESTMENT BALANCES 2019 2018 Investments 2019 Expenses Corpus 1,980,461 1,765,753 Research Committee Operations 104,666 65,984 Total Pool Investments 2,085,127 1,831,737
TOTAL NET ASSETS 2,085,127 1,831,737
NB. The Healy Financial Summary is an extract of the full financial statements. The full financial statements of the Healy Medical Research Foundation can be obtained from the Director upon request.
Medical Research Funding – 82% Management Fee – 18%
26 Raine Medical Research Foundation – Annual Report 2019 Suite 24, Hollywood Specialist Centre + 61 8 9386 9880 95 Monash Avenue, Nedlands [email protected] WA 6009 rainefoundation.org.au