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Advancing Chemistry. Improving Life

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Advancing Chemistry. Improving Life Advancing Chemistry. Improving Life. annual report 2004 ROBERT A. WELCH The Welch Foundation is a legacy to the world from Robert Alonzo Welch, a self-made man with a strong sense of responsibility to humankind, an enthusiastic respect for chemistry and a deep love for the state of Texas. Born in South Carolina to a prominent family that fell on hard economic times, Mr. Welch came to Houston as a youth and later made his fortune in oil and minerals. Over the course of his career and life, he became convinced of the importance of chemistry for the betterment of the world. Scientists, geologists and petroleum engineers were among his close friends and associates, as were the civic and business leaders of the day. From these associations and his own study, Mr. Welch determined that the pursuit of chemistry and chemical research held great potential for vast good and would continue to have a valuable impact on business, industry, global leadership and the human condition. Mr. Welch gave serious thought to the disposition of his estate. His decisions reflected his belief in science and the role it would play in the future. In his will, Mr. Welch stated: “I have long been impressed with the great possibilities for the betterment of mankind that lay in the field of research in the domain of chemistry.” With his death in 1952, Mr. Welch left a generous portion of his estate to his employees and their families. The balance began what is now The Welch Foundation. 3 Table of Contents 3 CHAIRMAN'S M ESSAGE 4 THE WELCH FOUNDATION 6 THE HACKERMAN AWARD 8 THE WELCH AWARD 10 CHEM ICAL RESEARCH CONFERENCE 12 PROGRAMS 14 FOUNDATION GRANTS 18 PRINCIPAL INVESTIGATORS 32 DEPARTM ENTAL GRANTS 33 ENDOWED CHAIRS 34 FINANCIALS CHAIRMAN’S MESSAGE 2004 Annual Report DUE TO THE FORESIGHT of Robert Alonzo As we prepare for Welch, The Welch Foundation has provided our next chapter, I am grants to support thousands of remarkable honored to announce chemists and their ideas since its founding in the appointment of a 1954. With this support – and the dedication of new member to the countless scientists – we have made tremendous board of directors who progress in advancing chemistry, improving life will offer guidance in and creating exciting new frontiers in the the coming years. Foundation’s first 50 years. Wilhelmina E. (Beth) Robertson joined the We have spent the past year celebrating these board in September and brings a great deal of accomplishments while, at the same time, eager- business acumen and a wealth of experience ly looking forward to the journey still ahead. with community organizations. Her commitment Through the past 50 years, Welch’s grants, schol- to the ideals the Foundation was founded on arships, endowed chairs and awards have helped will be a major asset as we continue on our many scientists in their search for answers. The exciting journey. answers they find are illuminating and exciting – As our 50th year anniversary becomes part of as are the new questions that arise. This ongoing history and we take our first steps into the process has led us to many new frontiers. In future, it is worth noting that things will surely years to come, this quest for knowledge will change. The people involved in our Foundation continue to push back boundaries as new gener- will change, the questions we ask may change, ations of bright chemists pursue their big ideas interdisciplinary lines will continue to blur with insatiable curiosity. and the scientific areas we support may acquire As we know, all great scientific journeys begin new names, but there is one thing that most with a question. Therefore, as we take our first certainly will remain constant: our mission. step into the next 50 years, we must ask our- Since its founding, The Welch Foundation has selves, “What’s next?” None of us knows all the supported scientists who advance chemistry new insights that are even now being gained in and improve life. With our shared commitment chemical labs across Texas – and across the to these ideals, we will continue to advance world. Nor can we specifically predict what our chemistry and improve life for the next 50 years deepening understanding will ultimately mean and beyond. to medicine, materials and technology. A half century ago, Robert Alonzo Welch didn’t know, and probably couldn’t fully envision, where his support for chemistry would R ICHARD J. V. JOHNSON eventually lead us. But he knew then – as we CHAIRMAN OF THE BOARD know today – that the journey is fascinating and rewarding. And we know that, in part, because we have come so far in the first 50 years. 5 THE WELCH FOUNDATION Leadership Dedicated to Foundation’s Mission Board of Directors Since 1954, The Welch Foundation has been dedicated to advancing chemistry and improving life through its support of basic research in chemistry. Its mission and ongoing operations are the responsibility of the board of directors, the The board of directors is charged with the stewardship of The Welch Foundation with scientific advisory board and a professional staff, responsibilities that include both the business and scientific operations of the Foundation. all of whom play critical roles in ensuring FROM LEFT Robert Welch’s vision continues to be carried out. Ernest H. Cockrell, secretary J. Evans Attwell, vice chairman Wilhelmina E. (Beth) Robertson Richard J. V. Johnson, chairman Dennis Hendrix, treasurer Long-time Board Member Charles Duncan Retires Charles W. Duncan, Jr. retired from The Welch Foundation’s board of directors in September, after almost 20 years of service. The board recognized Duncan’s lead- ership, dedication and contributions at the Welch Award banquet in October and presented him with a resolution to express its sincere appreciation for his long service, enthusiasm, ideas and dedication to the Foundation. Welch Foundation Chairman Richard J. V. Johnson, left, presents the board’s resolution to retiring board member Charles Duncan for his long-standing commitment and contributions to the Foundation. 6 Scientific Advisory Board STANDING FROM LEFT E. J. Corey, Harvard University Joseph L. Goldstein, The University of Texas Southwestern Medical Center at Dallas Norman Hackerman, SAB chairman, Rice University and The University of Texas at Austin Yuan T. Lee, Academia Sinica and University of California, Berkeley Peter G. Schultz, Scripps Research Institute and Genomics Institute of the Novartis Research Foundation The scientific advisory board (SAB) is comprised of nine SEATED FROM LEFT renowned leaders in chemistry and related sciences, Peter B. Dervan, including five Nobel laureates. The SAB advises the board California Institute of Technology of directors on scientific issues, evaluates proposals for William N. Lipscomb, Jr., research grants, reviews and considers nominations for Harvard University the Welch Award in Chemistry and the Norman Marye Anne Fox, Hackerman Award in Chemical Research, and one of its University of California, San Diego members presides over each annual conference. The SAB Ahmed H. Zewail, also helps oversee the Foundation’s visiting lecture series, California Institute of Technology and departmental grants and other programs. National Science Foundation Laboratory for Molecular Sciences Foundation Staff Led by President and Chief Operating Officer Norbert Dittrich, the staff oversees and implements the day-to-day operations of the Foundation. FROM LEFT Carolyn Kahlich, Norbert Dittrich, Carla Atmar, Kathy Kirk, Rachel Homme, Ron Page, Sherry White, Sindy Eskue. 7 THE HACKERMAN AWARD Ma Honored as Rising Star in Chemistry Fascinated by the structure-function relationship of The Norman Hackerman Award in Chemical Research, established in 2001, recognizes out- biological molecules, Jianpeng Ma uses computer standing young chemists at Texas institutions. In 2004, the award was presented to Dr. Ma, simulation as one tool to explore this connection. A associate professor at Baylor College of Medicine major research breakthrough occurred when he found and Rice University. Dr. Ma is the third person to be recognized a way to simulate protein by The Welch Foundation as a rising star in chemistry. The motion without knowing Hackerman Award pays tribute to the exact coordinates and Norman Hackerman, longtime chairman of The Welch amino acid sequences of Foundation’s Scientific Advisory Board. The award also serves to protein structures. His nurture the advancement of chemistry by recognizing excep- groundbreaking approach tional young scientists for their to biochemistry, biophysics groundbreaking chemical research. Dr. Ma received the honor at a and structural biology Jianpeng Ma (center) is congratulated on winning the 2004 Hackerman Award by Richard J. V. Johnson (left) luncheon held Feb. 3, 2004, in will help scientists better and Norman Hackerman. Dr. Ma is the third recipient the Texas Medical Center in of the award recognizing rising stars in chemistry. understand the chemical Houston. The award included a $100,000 check, certificate and specially basis for diseases. designed “rising star” crystal sculpture. “I am extremely honored to receive this pres- tigious award,” says Dr. Ma. “It is especially meaningful since I received my first grant in Texas from The Welch Foundation. The Foundation’s support has played an important role in my career and has allowed me to contin- ue much of my work. I am excited about the research challenges and possible discoveries that lie ahead, and hope that I can live up to the expectation of this award.” “Dr. Ma is an outstanding research chemist as well as a dedicated educator,” says Foundation Chairman Richard J. V. Johnson. “His love of learning and of teaching, combined with his per- sistence and diligence, are an inspiration to both his colleagues and students.” 8 In his joint appointment, Dr. Ma divides his “Dr. Ma is a rising star in the state of Texas,” time between Baylor College of Medicine’s says Salih J.
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