DuPont™ ® Air Cargo Covers Cold Chain Protection for Temperature Sensitive Cargo What is Tyvek® ?

• 100% HDPE

• Exceptionally Strong & Lightweight

• Highly Reflective

• High Puncture and Tear resistance

• Permeable

• Water Resistant

• White and Opaque

2 Tyvek® Air Cargo Covers for Pharmaceuticals

Performance Testing Results

3 12/3/2013 Tyvek® Air Cargo Covers for Pharmaceuticals Low Thermal Mass Testing Test Design Test Objective • Euro Size – 48”x32”x48” Evaluate the performance of DuPont™ Tyvek™ Air • 18 empty measuring 15”x15”x15” were Cargo Cover for Pharmaceutical vs. select stacked 3W X 2D x 3H competitive materials in such conditions where the • Temperatures were monitored at top center, impact of thermal mass is minimized. center of south facing side & inside the at the top south west corner

Tyvek® Metallized Bubble White Black Stretch wrap Clear Stretch wrap Pharma Cover (W/S) Wrap

4 12/3/2013 Low Thermal Mass Testing – Temperature Recordings

Type of Max cover Temp

Tyvek® 32C

MBW 37C

Clear 77C SW Black 52C SW

White 43C SW

Solar radiation is the leading cause of upward temperature excursions. 5 12/3/2013 Pharmaceutical Route Profile –Test Protocol

Test Objectives

Test the efficacy of DuPont™ Tyvek™ Air Cargo covers on: • Simulated Pharmaceutical load when exposed to the typical temperatures encountered during an international shipping route. • Compare the results to the control which consisted of an identical load protected by stretch wrap only.

Test Design • Euro Size pallet (48”x 32”x 48” – 2”W x 3”D x 3”H) grid pattern. • Boxes contained liquid filled pads to simulate a low to medium thermal mass content. ( 110 liters ) • Probes immersed into containing saline solution were used to monitor simulated product temperatures. • 7 data loggers were placed on each load for a total of 21 temperature readings per load. • No other packaging or insulated material was used.

The red dots mark the logger positions. The loggers are placed beneath the cover Tyvek Pharma (test item) and the wrapped foil 12/3/2013 (reference item). 6 Pharmaceutical Route Profile – Test Conditions

3 1 2 Aircraft Warehouse Tarmac 10C 20C 31C 10 hours 3 hours Partly cloudy 3 hours

4 5 Offloaded Airline Cold Warehouse Climate 18C -20C 3 hours 3 hours

12/3/2013 7 Pharmaceutical Route Profile- Testing Results

Warehouse Preconditioning Temperatures 20C ( no cover ) 3 hours Control Tyvek®Cover 21. 7C 21.6C

Tarmac 31C Tarmac Start & End Temperatures Mostly cloudy Control ( no cover ) Tyvek®Cover 3 hours 21.7C 35.9C 21.6C 26.3C

Aircraft Aircraft Start & End Temperatures 10C 10 hours Control ( no cover ) Tyvek®Cover 35.9C 14.5C 26.3C 16.4C

Offloaded Cold Climate Start & End Temperatures Cold Climate -20C Control ( no cover ) Tyvek®Cover 3 hours 14.5C -.06C 16.4C 6C

Airline Airline Warehouse Start & End Temps. Warehouse Control ( no cover ) Tyvek®Cover 18C

12/3/2013 3 hours -.06C 13.32C 6C 11.95C 8 Pharmaceutical Route Profile – Test Results Graph

Top Product Temperature (inside box)

40

30

D e 20 g r e 10 Control e TyvekTyvek®® cover kept load Tyvek® s 10C cooler ! 0

C TyvekTyvek®® cover kept load -10 6C warmer & prevented freezing !

-20 0 300 600 900 1200 1500 Elapsed Time, minutes

9 12/3/2013 Sales Contact: RTW Air Services SA

Tel: +41 79 446 2988

Bâtiment Fret / CP 1113 1211 Genève 5 Fret Switzerland

Walter Richner +41 79 446 2988 [email protected] www.rtwair.aero

www.rtwair.ch

Note All technical information set out herein is provided free of charge and is based on technical data which DuPont believes to be reliable. It is intended for use by persons having skill, at their own discretion and risk. The handling precaution information contained herein is given with the understanding that those using it will satisfy themselves that their particular conditions of use present no health or safety hazards. Since conditions of product use are outside of our control we make no warranties express or implied in relation thereto and therefore cannot accept any liability in connection with any use of this information. Nothing herein is to be taken as a license to operate under, or a recommendation to infringe any patents. DuPont™ Tyvek® Air Cargo Covers for Pharmaceuticals must be properly secured to the ULD if exposed to strong winds or turbines while on the tarmac. To maintain efficacy, DuPont™ Tyvek® Air Cargo Covers for Pharmaceuticals must be stored in the original package under dry, normal temperature conditions. New and used covers are expected to deteriorate if not properly protected from heat and humidity for long periods of time. DuPont is not liable for the efficacy of DuPont™ Tyvek® Air Cargo Covers for Pharmaceuticals beyond a limited period of time, as noted on the product . DuPont™ Tyvek® Air Cargo Covers for Pharmaceuticals have been designed for one-time or limited use in line with sanitary regulations and pest management best practices. Sufficient pre-cooling and correct temperature management from start of the cool chain is essential for optimal performance. DuPont is not liable for product damage during the use of the cover.

10 12/3/2013