Th eJournal of Immunology VOLUMME 197, NUMBER 1 • JULLY 1, 2 016 • WWW.JJIMMMUNOL.ORG 2016 Introductory Course in Immunology July 9–14, 2016 • Long Beach Convention Center, Long Beach, California Director: Juan Carlos Zuñiga-Pflücker, Ph.D. University of Toronto and Sunnybrook Research Institute

Don’t miss the most comprehensive introduction to immunology available! This intensive two-part course, taught by world-renowned immunologists, provides a comprehensive overview of the basics of immunology. This course is for students new to the discipline or those seeking more information to complement general biology or science training. Part I (July 9–11) is a detailed introduction to the basic principles of immunology and is suitable for students with a general biology background. Part II (July 12–14) is a clinically oriented lecture series focusing on specialty areas. Parts I and II may be taken independently at the discretion of the student. Faculty Juan Carlos Zuñiga-Pflücker, University of Toronto Stephen M. Hedrick, University of California, and Sunnybrook Research Institute San Diego Introduction to the Immune System Host-Pathogen Co-evolution in Human Beings: the Red Queen and the Grim Reaper Lewis L. Lanier, University of California, San Francisco Innate Immunity: Introduction to the Cells David C. Parker, Oregon Health and Science University T and B Cell Tolerance Deborah A. Fraser, California State University Matthias G. von Herrath, La Jolla Institute for Allergy Long Beach and Immunology Complement Autoimmunity Helen S. Goodridge, Cedars-Sinai Medical Center Olivia M. Martinez, Stanford University School Innate Immunity: Introduction to Pattern of Medicine Recognition and Intracellular Signaling Transplantation Wendy L. Havran, The Scripps Research Institute Peter B. Ernst, University of California, San Diego Introduction to Adaptive Immunity Mucosal Immunology Nilabh Shastri, University of California, Berkeley Marion Pepper, University of Washington Antigen Processing and Presentation Type 2 Immunity Juan Carlos Zuñiga-Pflücker, University of Toronto Linda A. Sherman, The Scripps Research Institute and Sunnybrook Research Institute Tumor Immunology MHC Restriction and Thymic Selection Robert L. Modlin, University of California, Los Angeles David Nemazee, The Scripps Research Institute David Geffen School of Medicine B Cell Development and Maturation Immunity to Bacterial Pathogens Shannon J. Turley, Genentech, Inc. Steven M. Varga, University of Iowa Dendritic Cells: The Bridge Between Innate Immunity to Viruses and Adaptive Immunity Martin Prlic, Fred Hutchinson Cancer Research Center Michael Croft, La Jolla Institute for Allergy Immunologic Memory and Immunology Effector T Cell Differentiation and Response Nicole Frahm, Fred Hutchinson Cancer Research Center Vaccination Shane Crotty, La Jolla Institute for Allergy and Immunology Jennifer M. Puck, University of California, B Cell Activation and Humoral Immunity San Francisco Arthur Weiss, University of California, San Francisco Genetic Approaches to Immune-Mediated Diseases Signaling in the Immune System Andrew C. Chan, Genentech, Inc. Wenjun Ouyang, Amgen Bench to Bedside to Bench: Current Issues Cytokines in Immunology

For complete course details and registration, visit: www.aai.org/Education/Courses For assistance, contact (301) 634-7178 or [email protected]. Overseas applicants are advised to apply early for visas; for details, visit www.aai.org/Education/Courses/Visa.html. 2016 Advanced Course in Immunology July 31–August 5, 2016 • Seaport World Trade Center, Boston, Massachusetts Director: Ulrich H. von Andrian, M.D., Ph.D. Harvard Medical School and Ragon Institute at MGH, MIT and Harvard

Don’t miss the premier course in immunology for research scientists! This intensive course is directed toward advanced trainees and scientists who wish to expand or update their understanding of the field. Leading experts will present recent advances in the biology of the immune system and address its role in health and disease. This is not an introductory course; attendees will need to have a firm understanding of the principles of immunology. Faculty Ulrich H. von Andrian, Harvard Medical School and Leslie J. Berg, University of Massachusetts Ragon Institute at MGH, MIT and Harvard Medical School Anatomy of the Immune Response Signaling from Antigen Receptors Jonathan C. Kagan, Children’s Hospital Boston Stephen C. Jameson, University of Minnesota Center Harvard Medical School for Immunology Innate Immunity: Pattern Recognition and T Cell Memory Anti-microbial Mechanisms Patrick C. Wilson, University of Chicago Bruce Horwitz, Brigham & Women’s Hospital, B Cell Memory Harvard Medical School Innate Immunity: Gene Regulation Arup K. Chakraborty, Massachusetts Institute of Technology Albert S. Bendelac, University of Chicago Computational Modeling of Immunological Innate Immunity: Cellular Mechanisms Processes Wayne M. Yokoyama, Washington University School Brian A. Cobb, Case Western Reserve University of Medicine NK Cells — Their Receptors and Function in School of Medicine Glycoimmunology Health and Disease Michael C. Carroll, Immune Disease Institute Richard S. Blumberg, Brigham & Women’s Harvard Medical School Hospital, Harvard Medical School Molecular and Cellular Mediators Mucosal Immunity of Inflammation Joel D. Ernst, New York University School of Medicine Brian T. Edelson, Washington University School Immune Response to Pathogens of Medicine Jennifer Anolik, University of Rochester Medical Center Dendritic Cells B Cell Tolerance and Autoimmunity Eugene M. Oltz, Washington University School Vijay K. Kuchroo, Brigham & Women’s Hospital, of Medicine Harvard Medical School The Generation and Modification of Lymphocyte T Cell Tolerance and Autoimmunity Antigen Receptor Genes Kevin J. Tracey, Feinstein Institute for Medical Research Kay L. Medina, Mayo Clinic Neuroimmunology B Cell Development Lisa H. Butterfield, University of Pittsburgh Avinash Bhandoola, NCI, NIH Tumor Immunology T Cell Development Dania Rabah, Biogen Idec Kenneth L. Rock, University of Massachusetts Immunotherapeutics Medical School MHC-Restricted Antigen Presentation to T Cells Dennis W. Metzger, Albany Medical College Vaccines

For complete course details and registration, visit: www.aai.org/Education/Courses For assistance, contact (301) 634-7178 or [email protected]. Overseas applicants are advised to apply early for visas; for details, visit www.aai.org/Education/Courses/Visa.html. Celebrating a Century: Top Ten Most Cited Articles in The Journal of Immunology

Serving the immunology community for the last 100 years, The Journal of Immunology continues to report novel findings in all areas of experimental immunology. Many articles have proven to be foundational in the field and are cited again and again. Collectively, the top ten most-cited articles have garnered over 30,000 citations!

Number of Article Citations*

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins 5397 T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, and R L Coffman J Immunol 1986 136:2348-2357 T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity 4201 Steven Gillis, Mary M. Ferm, Winny Ou, and Kendall A. Smith J Immunol 1978 120:2027-2032 Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases 3808 S Sakaguchi, N Sakaguchi, M Asano, M Itoh, and M Toda J Immunol 1995 155:1151-1164 Rapid Isolation of Antigens from Cells with a Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A 3207 Steven W. Kessler J Immunol 1975 115:1617-1624 Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67 3161 J Gerdes, H Lemke, H Baisch, H H Wacker, U Schwab, and H Stein J Immunol 1984 133:1710-1715 Enzyme-Linked Immunosorbent Assay, Elisa: III. Quantitation of Specific Antibodies by Enzyme-Labeled Anti-Immunoglobulin in Antigen-Coated Tubes 2773 Eva Engvall and Peter Perlmann J Immunol 1972 109:129-135 Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1) 2487 M L Dustin, R Rothlein, A K Bhan, C A Dinarello, and T A Springer J Immunol 1986 137:245-254 Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production 2485 A H Ding, C F Nathan, and D J Stuehr J Immunol 1988 141:2407-2412 Application of a Microtechnique to Viral Serological Investigations 2340 John Louis Sever J Immunol 1962 88:320-329 Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product 2227 Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, and Shizuo Akira J Immunol 1999 162:3749-3752

* Data from Web of Knowledge as of September 17, 2015.