White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial
Journal of Alzheimer’s Disease 78 (2020) 75–86 75 DOI 10.3233/JAD-200423 IOS Press White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial Ruth Stephena, Alina Solomona,b, Tiia Ngandub,c, Esko Levalahti¨ c, Juha O. Rinned,e, Nina Kemppainend,e, Riitta Parkkolad, Riitta Antikainenf,g, Timo Strandbergf,h, Miia Kivipeltoa,b,i,j, Hilkka Soininena,k and Yawu Liua,l,∗ for the FINGER study group aInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland bDivision of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden cPublic Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland dDivision of Clinical Neurosciences, Turku University Hospital, Turku, Finland eTurku PET Centre, University of Turku, Turku, Finland f Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland gMedical Research Center Oulu, Oulu University Hospital and Oulu City Hospital, Oulu, Finland hDepartment of Medicine, Geriatric Clinic, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland iInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland jAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom kNeurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland lDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland Accepted 1 August 2020 Abstract. Background: Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.
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