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Advances in the Brain and Behavioral Sciences Advances in the Brain and Behavioral Sciences Presented by John Arden, Ph.D. Disclosure Neither Dr. John Arden, the presenting speaker, nor the activity planners of this program are aware of any actual, potential or perceived conflict of interest Sponsored by Institute for Brain Potential PO Box 2238 Los Banos, CA 93635 COURSE OBJECTIVES Participants completing the program should be able to identify evidence‐based approaches to: 1. Overcoming traumatic and posttraumatic stress related disorders including adverse childhood and adult experiences. 2. Understanding and managing generalized anxiety disorder, social anxiety disorder, and perfectionism. 3. Enhancing emotional resilience 4. Improving health‐related habits 5. Understanding and applying mind‐body approaches to improve the mind‐body connection as it affects the immune system and inflammation. 6. Understanding and improving interpersonal relationships including reasoning with unreasonable people and high‐conflict interactions. 7. Describing how food affects mental health 8. Understanding and improving memory and cognition and preventing dementia. 9. Adopting lifestyle modifications for improving physical activity, diet, meditation and sleep. 10. Applying positive psychology. Policies and Procedures 1. Questions are encouraged. However, please try to ask questions related to the topic being discussed. You may ask your question by clicking on “chat.” Your questions will be communicated to the presenter during the breaks. Dr. Arden will be providing registrants with information as to how to reach him by email for questions after the day of the live broadcast. 2. If you enjoyed this lecture and wish to recommend it to a friend or colleague, please feel free to invite your associates to call our registration division at 866-652-7414 or visit our website at www. IBPceu.com to register for a rebroadcast of the program or to purchase a copy of the DVD. 3. If you are unable to view the live web broadcast, you have two options: a) You may elect to download the webinar through Friday, December 22, 2017. IBP will automatically provide you with a new link to receive the program. b) You may request a free copy of the DVD set of this program and the instructional materials. Send an email to IBP at ceu@4brain.org, fax us at 209-710-8306 or mail the IBP Home Study Division at 245 W Pacheco Blvd, Suite C, Los Banos, CA 93635. Please provide us with your mailing address. If you are not fully satisfied with the DVD and instructional materials, return them to IBP and receive a credit for a future seminar or webinar offered within the next 12 months. 4. IBP recorded lectures are designed for individual use and cannot be used by outside organizations for instructional purposes without the written consent of IBP. 5. For American Disability Act accommodations or for addressing a grievance, please contact customer service at 888-202-2938 or write to IBP at PO Box 2238, Los Banos, CA 93635. 6. Post webcast materials are available for each participant at the following URLs: Live Webcast Evaluation: http://www.ibpceu.com/content/pdf/behavioral-f17-eval.pdf On-Demand Webcast Evaluation: http://www.ibpceu.com/content/pdf/behavioral-f17-dl-eval. pdf All licensed health professionals are required to complete all pages. Please transmit by Friday, December 22, 2017. 7. IMPORTANT: Your certificate of completion will be available by email, mail or fax following receipt of your fully completed evaluation form. If you request the certificate by mail, it will be mailed within 2 business days upon receipt of your fully completed evaluation form. In the unlikely event that you lose your certificate, please send your request in writing and a check for $20 payable to IBP at PO Box 2238, Los Banos, CA 93635, email reporting@ibpceu.com, or call 866 -652-7414. IBP is a nonprofit scientific and educational organization dedicated to promoting advances in behavioral medicine. IBP is entirely supported by the tuition it charges for its seminars and the sale of educational materials. Neither IBP, its planning committee, nor any of its instructors has a material or financial interest with any entity, product, or service mentioned in the seminar unless such relationship is disclosed at the beginning of the program. The information presented is of a general nature. For specific advice, please consult a specialist in your area. Advances in the Brain and Behavioral Sciences The Ten Certificate Programs 1. Understanding and Overcoming Trauma 2. Understanding and Managing Anxiety 3. Developing Emotional Resilience 4. Improving Health-Related Habits 5. The Immune System, Inflammation and the Mind-Body Connection The Ten Certificate Programs UNDERSTANDING AND OVERCOMING TRAUMA 6. Managing Interpersonal Conflicts A Certificate Program 7. How Food Affects Mental Health 8. Understanding Memory, Cognition and Earn 12 hours of CE and a Certificate: Dementia Lecture 1: Adverse Childhood Events 9. Lifestyle Modification to Create Lecture 2: Understanding and Treating PTSD Meaningful Change 10. Applying Positive Psychology John Arden, PhD, ABPP John D. Preston, PsyD, ABPP Dr. Arden is the Chief Academic Officer for IBP. Dr. Preston has been Professor at Alliant The author of 15 books, he was previously the International University. He is the author Northern California Director of Training of numerous texts concerning brain and overseeing 24 Kaiser Permanente medical centers with 150 interns and postdoctoral behavior. residents. He received the Mental Health He has been instrumental in developing the Association’s President’s Award for certificate program and enabling IBP attendees exceptional contributions to the mental to receive graduate credit for taking IBP health community. He has taught for the lectures. For questions email him at: Institute since the 1990s. drjohnarden.ibp@gmail.com 1 Categories of Adverse The ACE Study Childhood Experiences Abuse, by Category Category • Examined the health effects of ACE’s throughout the lifespan among 17, 421 Prevalence (%) members of Kaiser Permanente in San • Psychological (by parents) 11% Diego county • Physical (by parents) 11% • Sexual (anyone) 22% • What are Adverse Childhood Experience? Household Dysfunction, by Category • Substance Abuse in family 26% – Childhood abuse and neglect • Mental Illness in family 19% – Growing up with domestic violence, • Domestic Violence 13% substance abuse, parental discord, • Imprisoned Household Member 3% crime, or mental illness in the home • Loss of parent 23% The ACE Score and the Prevalence of ACEs score percentages Severe Obesity (BMI>35) Number of categories of childhood experiences ACE Score are summed Prevalence 0 48% 1 25% 2 13% 37% 47% Percent obese (%) • More than half have at least one ACE • Slightly more than one quarter have experienced ACE Score 2 – 4 ACE categories The ACE Score and a History of Sexual Abuse of Male Children and Their Lifetime Depression Likelihood of Impregnating a Teenage Girl 1.8x 1.3x 1.4x 1.0 ref Percent depressed (%) ACE Score Not 16-18yrs 11-15 yrs <=10 yrs abused Age when first abused 2 The ACE Score and the Prevalence of ACE Scores and Attempted Suicide History of STDs Percent attempted (%) ACE Score Childhood Sexual Abuse and the ACE Score and Hallucinations Number of Unexplained Symptoms Abused Number of Symptoms Alcohol 0 1 2 3 4 5 6 7 8 or Drugs (%) Percent Abused Abused Percent Ever (%) Hallucinated* Ever History of Childhood Sexual Abuse ACE Score *Adjusted for age, sex, race, and education. ACE Score and Indicators of ACE Score and Rates of Impaired Worker Performance Antidepressant Prescriptions 25 ACE Score approximately 50 years later 0 1 2 3 4 or more 20 4 5 or more 15 3 10 2 1 Performance Performance (%) 5 Prevalence Prevalence of Impaired Prescription Prescription rate 0 per 100 person-years) 0 Absenteeism (>2 Serious Financial Serious Job ACE Score days/month Poblems Problems 3 Effect of ACEs on Death Rate Death Age Group Early Death Disease, Disability and Social Problems Adoption of Health-risk Behaviors Social, Emotional, & Cognitive Impairment Adverse Childhood Experiences The Science has Changed Epigenetics “Mental functions direct electrochemical traffic at the cellular level” Roger Sperry “Psychotherapy works by producing changes in gene expression that alter the strength of synaptic connections…” Eric Kandel Epigenetics and Increased Stress Epigenetics and Decreased Stress • Increased methylation levels of cortisol receptor • Decreased methylation levels of cortisol gene: receptor gene: • In suicide victims with a family history of • In offspring who had good nurturing abuse and/or neglect • Also in preemies: produces more cortisol receptors on the • Can’t easily turn off the stress response hippocampus • Decreased methylation of the arginine • Lower levels of CRH, ACTH, and vasopressin gene cortisol • If stressed early in life: • More 5-HT • Resulting in increased vasopressin and stimulating the stress response • Stress tolerance (Good thermostat) 4 Cell Aging: Telomeres Length Stress and Telomeres * • “Psychobiomarker”: Linked to social status, perceived stress, depression, predictive of mortality (Epel, 2009, Current Directions) • •Telomeres: non-coding sequences capping ends, serving as a Chronic stress and perceived stress were associated with • “senescence clock” (Blackburn, 1978) shorter telomeres as well as reduced telomerase. • •Telomerase: enzyme that prevents Women with the highest levels of perceived stress have shortest telomeres telomere shortening, promotes cell Shorter
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