Annual Report 2017

Cover: A nanoparticle (red) being absorbed by the surface of a cancer cell. Image: A/Prof John McGhee, John Bailey (UNSW Art & Design) Contents

2 3 Directors’ At a Glance Report 3 4 ACNDirectors’ 2017 Summary Report 4 Governance, Our People & Visitors 5 Gove 5 Associated Faculties and Schools

6 Steering Committee 7 Centre Directors 8 ACN Staff and Students 12 Visitors to the ACN

14 Research Highlights

15 2017 Grant Funding 17 2017 Newly Funded Projects

19 High Impact Papers 21 Engagement & Activities

22 Awards, Honours and Achievements

25 Editors of Journals 26 Eureka!

27 Media 30 Nanomedicine Conference

31 ACN Activities

35 Collaborating Organisations 36 Presentations & Publications 37 Presentations 42 Publications 51 Financial Report

1 Directors’ Report

The Australian Centre for NanoMedicine (ACN) was established in mid-2011 as a national innovator in NanoMedicine, bringing together a diverse team of leading researchers in Medicine, Science and Engineering to deliver the next generation of health innovations, and is dedicated to providing new solutions for therapeutics and diagnostics enabled by nanotechnology.

The key science that underpins all the activities of the Centre is to fully understand and exploit the unique properties of nanomaterials for various applications (eg. nanosensors for cell imaging and therapeutics for treating cancer). The Centre’s strategic vision is to create teams focused on particular diseases using Team ACN’s skills in drug delivery, diagnostics and imaging.

To succeed in this, it requires an integrated team of researchers coming from diverse backgrounds and we have assembled a remarkable team of highly distinguished scientists and engineers covering nanotechnology, polymer science, cancer biology, chemical engineering, microfluidics, chemistry, sensors and imaging, social science and experimental arts (3D imaging) from five UNSW faculties: Medicine, Science, Engineering, Arts & Social Sciences, and Art and Design.

Towards end of 2017 the Centre’s Management Team re-examined the Centre’s vision and priorities in response to a changing UNSW landscape and new grant funding environment. Management has since developed a new strategic plan to harness our full potential. The new strategic focus moving forward will focus on the following three themes:

People/ Talent Our people and their commitment to excellence are our strength. To retain, attract and develop emerging and leading researchers is our Strategic focus. We have recruited 5 new members in 2017, including Prof Liming Dai, UNSW SHARP hire; Dr Kris Kilian and Dr Kang Liang, both UNSW Scientia Fellows; Dr Iman Roohanie, NHMRC ECF Fellow; and Dr Robert Chapman, ARC DECRA Fellow.

The Centre seeks to develop emerging leaders and retain talents through workshops and Seed Funding and providing postdoc and PhDs the opportunity to host workshops, visitors and chair Nanomed Conference sessions.

Research Focus/ Engagement The Centre aims to transform from bottom-up driven to end-user industry & clinician driven. To achieve this goal, we’ve introduced a Clinical Challenges Session and Industry Session at our annual Nanomed Conference. These sessions have already achieved pleasing results and led to collaborations and linkages, incl. Justin and Maria’s ARC Linkage Project with Inventia on 3D printing (see Research section for details).

The Centre has actively engaged with Translational Cancer Research Network (TCRN) NSW and is working towards becoming a member of TCRN. A TCRN/ACN Clinical workshop was held on Friday 17 Nov 2017 where our Centre Directors pitched to a broader clinical audience on big picture Nanomedicine and potential. Maria gave an overview of the ACN and capabilities, Cyrille gave a talk on “Nanomedicine for antimicrobial use” and Justin talked about “The potential of nanosensors and diagnosis for clinical use”.

Profile ACN has gone from strength to strength from its inception in 2011. We strive to continue to strengthen our high profile through a number of initiatives, including: becoming part of Translational Cancer Research Centres NSW and addressing the disease problems, producing high quality publications and hosting the annual International Nanomedicine Conference, attracting and retaining high quality researchers.

These and several other key achievements during 2017 are summarised in the body of this annual report. These achievements contributed to making 2017 an extremely successful year for the Centre. We look forward to similar progress in 2018 and in subsequent years.

Justin Gooding Maria Kavallaris Cyrille Boyer Centre Co-Director Centre Co-Director Centre Co-Director

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ACN 2017 Summary

Our People

1 University Medalist 33 PostDocs and and 14 PhD Research Associates and Completions/ 4 Associated Members 21 Members incl 11 Self- Funded Research Fellows, 1 Submissions in 2017 SHARP Appointment and 2 Scientia Fellows 80 Honours and PhD 16 Administration and Students including 4 Technical Staff Scientia PhDs

Research Output

ACN members and students 150 Journal Publications plus Over $11.5M new funding to worked on 13 10 Conference Proceedings fund projects commencing in interdisciplinary research in 2017 2017 projects in 2017

ACN hosted 8th International 35 Plenary, Keynote and 49 seminars, oral NanoMedicine Conference Invited talks by Team ACN in presentations and poster 3-5 July 2017 where many 2017 at major international presentations by team ACN ACN researchers presented conferences, incl 12 overseas at universities, symposiums their research and 15 with financial support and meetings in 2017

Team ACN actively 24 visitors (including 20 collaborated with 56 26 memberships on Editorial international) visited ACN in organisations in 2017 Boards in 2017 2017 to discuss research including 36 overseas collaboration organisations

2017 major awards incl. Justin Gooding's Eureka Prize in Mentoring and Katsumi Niki Prize in Team ACN garnered over 90 media Bioelectrochemistry, Maria Kavallaris' Premier's Science articles (including TV & Radio) both and Engineering Award for Leadership in Innovation in in Australia and overseas in 2017 NSW

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Governance, Our People and Visitors

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Associated Faculties and Schools

The Australian Centre for NanoMedicine is a unique Centre in that it draws members from several faculties, schools, institutes and centres across UNSW.

Presiding Faculty - Faculty of Engineering Associate Faculties - Faculty of Science Faculty of Medicine Faculty of Art and Design Faculty of Arts and Social Sciences Host School - School of Chemical Engineering Associate Schools - School of Chemistry School of Medical Sciences School of Humanities and Languages School of Women’s and Children’s Health Graduate School of Biomedical Engineering School of Materials Science and Engineering School of Mechanical and Manufacturing Engineering Associate Institutes - Children’s Cancer Institute

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Steering Committee

The Steering Committee provides support, guidance and oversight on strategy and stakeholder engagement as well as monitoring progress towards the delivery of key performance indicators and other objectives. The ACN Steering Committee is chaired by Professor Mark Hoffman (Presiding Dean) and is comprised of members from the associate Faculties of Science and Medicine. The 2017 Steering Committee meetings are noted below.

Steering Committee Members May 1 Jul 31 Nov 14 Professor Mark Hoffman ● ● ● (Chairman) Dean of Engineering, UNSW

Professor Emma Johnston ● Dean of Science, UNSW (from July 2017)

Professor Rodney Phillips ● Dean of Medicine, UNSW (Mark Ainsworth deputised for Rodney Phillips)

Professor Peter Lovibond ● ● Deputy Dean of Science, UNSW

Scientia Professor Ian Dawes ● ● ● School of Biotechnology and Biomolecular Sciences, UNSW

Scientia Professor Justin Gooding ● ●

ACN Co-Director School of Chemistry, UNSW

Professor Maria Kavallaris ● ● ● ACN Co-Director Children’s Cancer Institute

Professor Cyrille Boyer ● ● ● ACN Co-Director School of Chemical Engineering, UNSW

Kimberly Edmunds ● ● ● Centre Manager Australian Centre for NanoMedicine

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Centre Directors

Scientia Professor J. Justin Gooding Editor-in-Chief, ACS Sensors ARC Australian Laureate Fellow School of Chemistry, UNSW Sydney

Scientia Professor Justin Gooding is currently an ARC Australian Laureate Fellow, the co-director of the Australian Centre for NanoMedicine and the co-director of the New South Wales Smart Sensing Network. He is a Fellow of the Australian Academy of Science and the International Society of Electrochemistry. He is also editor-in-chief of the journal ACS Sensors. He has won many awards including a 2004 NSW Young Tall Poppy award, the 2009 Eureka Prize for Scientific Research, the 2013 NSW Science and Engineering Award for Emerging Research, the 2016 Faraday Medal of the Royal Society of Chemistry and the 2016 Biosensors and Bioelectronics Award. He leads a research team of over 40 researchers interested in sensors for medical diagnostics, nanomedicine, 3D printing of cells for biomedical research and biomaterials.

Professor Maria Kavallaris FAHMS Head, Tumour Biology & Targeting Program Children's Cancer Institute

Professor Maria Kavallaris, Founding Director, Australian Centre for NanoMedicine, UNSW, and Program Head, Children’s Cancer Institute Australia. She holds a prestigious NHMRC Principal Research Fellowship and is an internationally recognized leader in cancer biology, therapeutics and cancer nanomedicine. Her research has led to clinical collaborations and industry linkages that is maximising translation of her research. She is a Fellow of the Australian Academy of Health and Medical Sciences. Professor Kavallaris has received numerous national and international awards and prizes including an Australian Museum Eureka Award, AIPS Young Tall Poppy Award, 2015 AFR/Westpac 100 Women of Influence Award, recognized in the 2015 Knowledge 100 Australian Innovators and the 2017 Premier’s Science and Engineering Award for Leadership in Innovation in NSW.

Professor Cyrille Boyer PhD School of Chemical Engineering, UNSW Sydney

Professor Cyrille Boyer is the Co-Director of Australian Centre for NanoMedicine. He received many awards including the 2012 SCOPUS Young Researcher of the Year Award, the 2015 Prime Minister's Science Prize, the 2016 LeFevre Memorial Prize, ARC-APD and ARC-Future Fellowship in 2010 and 2012 respectively, and was nominated as one of the inaugural Knowledge Nation 100 in 2015. Cyrille’s research has gained international recognition, winning the prestigious ACS Biomacromolecules/ Macromolecules Award and Journal of Polymer Science Innovation Award in 2016. Cyrille's research interests mainly cover the use of photoredox catalysts to perform living radical polymerization and functional polymers for therapeutic applications (for example, polymers with anti-microbial properties). He holds 6 international patents and has published over 200 research articles including 24 highly cited papers according to ESI Web of Science.

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ACN Members

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2017 New Members

Professor Liming Dai is a fractional UNSW SHARP (Strategic Hires and Retention Pathways) appoint to School of Chemical Engineering in July 2017 and joined ACN the same month. Professor Dai comes from the Department of Macromolecular Science and Engineering at Case Western Reserve University in the US and has an outstanding CV with over 30,000 citations. Prof Dai would be a great asset to ACN.

Dr Kristopher Kilian is a Scientia Fellow with a joint appointment to School of Chemistry and School of Materials Science and Engineering. He worked for Merck Research Labs in the Methods Development group from 2000-2004 before travelling to Sydney to do his PhD with Justin Gooding at UNSW. In 2007, he joined the Milan Mrksich lab at the University of Chicago as a NIH postdoctoral fellow. Kris joined the University of Illinois at Urbana- Champaign in 2011. Kris is a 2008 recipient of the NIH Ruth L. Kirchstein National Research Service Award, a 2014 Kavli Fellow of the 19th German-American Frontiers of Science, a 2015 recipient of the National Science Foundation’s CAREER award, and a 2017 Young Innovator of Cellular and Molecular Bioengineering from the Biomedical Engineering Society (BMES).

Dr Kang Liang is a Scientia Fellow with a joint appointment to School of Chemical Engineering and The Graduate School of Biomedical Engineering. Kang joined ACN in August 2017. Kang is also an Honorary Fellow at The University of Melbourne and Monash University. In 2015, Dr Kang Liang developed a new technique for fingerprinting by creating an ultraviolet light to recapture fingerprints at crime scenes by making them "glow"; he also developed a new technology in the same year that can protect proteins in drugs and vaccinations from heat, bacteria and other hostile environments by applying the concept of a sea urchin's shell. Dr Liang is an awardee of Victoria Fellowship in Physical Sciences in 2017.

Dr Iman Roohani is a NHMRC ECF Fellow and joined the Gooding Group at School of Chemistry and ACN in mid-2017. Iman received his PhD in 2014 from USyd. His PhD discovery is now being commercialised by Allegra Orthopaedics. Allegra was awarded $1.6M from the NSW Government Medical Devices Fund in 2015 to bring this technology to market. Iman has received many honours and awards through his career. Since joining ACN, Iman has received 2 major NHMRC Project Grants including one as Sole CI, A Targeted Delivery System for Treatment of Bone Metastasis, $243,607.

Dr Robert Chapman is an ARC DECRA fellow at the School of Chemistry. He joined ACN in August 2017. Robert completed his PhD in Chemistry at the University of Sydney in 2013. He subsequently worked as a research associate in the lab of Prof. Molly Stevens at Imperial College London (2013-15) on the development of nanomaterial based biosensors and scaffolds for tissue engineering, before returning to UNSW in 2016. Robert uses enzymes to design multivalent polymer-peptide conjugates for protein binding applications and to design novel biosensors for the detection of disease. He has expertise in well controlled polymerisation techniques, the self-assembly of polymer and peptide based nanomaterials, and in nanoparticle based biosensing.

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Associate Members PhD & Honours Mr Walter Muskovic Ms Helen Forgham Students Mr Abu Sadat Md. Sayem Rahman Professor Martina Stenzel Mr Bijan Po

A/Pro Shelli McAlpine Mr Lachlan Carter Mr Simone Bonaccorsi*# Dr May Lim Mr Manish Sriram Mr Cong Vu*# Dr Renee Whan Mr Mehran Bolourian Kashi Ms Munkhshur (Shuree) Myekhlai*# Mr Peter O'Mara Mr Agus Poerwoprajitno*# Mr Sanjun Fan Research Fellows Ms Gervase Ng* Mr Yanfang Wu Mr Sihao Xu* Ms Duyen Nguyen Dr Elizabeth Hinde ** Mr Peter Judzewitsch* Ms Fida'a Alshawawreh Dr S R C Vivekchand (VC) Mr Chenyu Wu* Ms Kelly Zong Ms Alicia Cheng* Dr Enrico Klotzsch (VC)** Ms Manchen Zhao Ms Yiping Wang* Dr Yuanhui Zheng (VC)** Ms Mohadesseh Kahram Mr Ahmed Mustafa* Dr Hongxu Lu (DECRA) Ms Raheleh Pardekhorram Ms Panthipa Suwannakot* Dr. Padmavathy Bakthavathsalam Mr Abbas Darestani Farahani Mr Ali Alinezhadcham* (Trust-India Fellow) Mr Eric Du Mr Timothy Snailham* Dr. Yuhua Xue (VC) Ms Genevieve Duche Miss Yingying Chu* Dr Vinicius Goncales* Ms Kristel Tjandra Mr Zixuan Huang* Ms Susan Tan Mr Hsiang-Sheng Chen* Mr Nik Nik Mohd Adnan Post Docs Ms Jianxin Lily Lian* Ms Sri Augustina Ms Sharmin Maitry* Mr Ali Bagheri Dr Christopher Fife* Ms Wenxian Tang* Mr Nat Corrigan Dr Georgia Miller* Ms Zerong Ma* Mr Xiankan He Ms Florida Voli* Dr Chin (Ken) Wong* Mr Kenward Jung Ms Tara McDonnell* Dr Fabio Lisi* Ms Susan Oliver Ms Mahdie Mollazade** Dr Jonathan Wojciechowski* Mr Zhenbang Cao Mr Chin (Ken) Wong** Dr Ernesto Moles* Mr Shashidhar Nizalapur Mr Jonathan Wojciechowski** Dr Jonathan Yeow* Mr Ming Han Eugene Yee Mr Md. Musfizur Hassan** Mr Kumar Bishwajit Dr Amelia Parker** Ms Georgia Miller**

Dr Parisa Sowti** Mr Saimon Silva** Dr James Webb** Mr Fei Han** *Joined in 2017 Dr Roya Tavallaie** Mr Yosef Arman** **Submitted /Left in 2017 # Scientia PhD Dr Declan Kuch Ms Leila Zarei**

Dr Friederike Mansfeld Mr Vincent Tan** Ms Ranjana Piya** Dr Lakmali Atapattu Mr Siva Shanmugam** Dr Sela Pouha Ms Khanh Nguyen** Dr Wee Siang Teo Mr Jonathan Yeow** Dr Marion Le Grand Ms Aria Ahmed-Cox** Dr Andrew McGrath Mr Michael Lawler** Dr Robert Utama Mr Alexander Rashleigh** Dr Stephen Parker Ms Holly McEwen** Dr Wenqian Wang Mr Alexander Kross Ms Joanna Kwiatek Dr Ying Yang Mr Alex (Yuanqing) Ma Dr Alistair Laos Mr Jason Tran Dr Thibault Tabarin Ms Lucy Gloag Dr Tania Benedetti Mr Cameron Kelly Dr David Chang Above: Gooding Group & Kavallaris Lab

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Meet our Scientia PhDs

Munkhshur Myekhlai received her bachelor degree in Chemical Engineering and master degree in Science of Nanoengineering from the National University of Mongolia (Mongolia). Her recent research concerns the synthesis of magnetic metallic nanoparticles and in particular cobalt and Au nanoheterostructures in the electrocatalysts. She has expertise in the metallurgy, 2D nanomaterials, and electrochemistry. Her current PhD project title is: Cobalt and Au nanoparticles for electrocatalysts.

Simone Bonaccorsi holds a BS in Electronic Engineering from Politecnico of Turin (Italy), MS in Nanotechnology, joint degree between Politecnico of Turin (Italy), EPFL (École polytechnique fédérale de Lausanne, Switzerland) and Grenoble INP Phelma (France). His background spans applications in engineering, nanotechnology, biology, immunology, genomics and bio-nanotechnology. He has worked in different technology and biotechnology-related industries as well as research institutes worldwide such as Riken (Tokyo, Japan) and Ludwig Cancer Research (Lausanne, Switzerland). He has also worked in Harvard-MIT Health Science and Technology, Imperial College London.

T Cong’s research is mainly focusing on the synthesis mesoporous silica nanorods, and then compare the cellular uptake of nanorods to the traditional nanospheres while the surface chemistry and diameter are kept similar to understand the role of shape on uptake pathway. Surface chemistry and size of mesoporous silica nanoparticles have been extensively studied, but the impact of shape has been little understood with near exclusive use of spherical shape. Despite this relative limited volume of papers, mesoporous silica nanorods have been shown to give significant improvement in drug delivery.

Agus R. Poerwoprajitno received B.Eng. degree from Diponegoro University in 2014 and M.Sc. degree from National Taiwan University of Science and Technology in 2015. He then worked as a research assistant in Institute of Chemistry, Academia Sinica. His previous research experience focused on mechanistic study of hydrogen production by iron thiolate catalyst. He joined in Prof. Tilley's group as Scientia Ph.D. student in July 2017. Currently, his research interest includes synthesis of nanoparticle for energy-related applications. In March 2018, he works as visiting doctoral student at the Center for Integrated Nanotechnologies (CINT), Sandia National Laboratories, USA.

Centre Administration

Kimberly Edmunds Mr Campbell Strong Mr. James Wilmot Centre Manager Researcher (From 2017) Research Assistant (From Jan 17)

Dr Joshua Peterson Ms Rose-Marie Olsson Dr Robert Healey Research Officer (To Dec 2017) Senior Research Assistant Research Assistant (From Feb-17)

Mr Eh Hau Pan Ms Kathleen Kimpton Ms Victoria Gernedl Lab Manager Senior Research Assistant Research Trainee

Dr Andrew Lilja Mrs Sona Samuels Ms Jesu Schlogl (To July 17) Researcher (From 2017) Research Assistant Ms Claudia Demech (Jul- Oct 17) Ms Samantha Ellis (From Oct 17) Mr John Bailey Ms Efremova Varvara EA to Prof Kavallaris Researcher Research Assistant

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Visitors to the ACN

The ACN has hosted a diverse range of visitors from academia and industry within Australia and around the world during 2017. Our visitors have presented seminars and met with research staff and students to investigate potential collaboration opportunities.

Prof Hiroaki Kitagawa Prof Wolfgang Parak A/Prof Lisa Butler Department of Applied Life Head of Biofunctional ARC Future Fellow Sciences Nanomaterials University of Adelaide Gifu Univeristy Philipps University of Marburg Australia Japan Germany Dr Robert Ramsey Prof Barbara Prainsack Prof Helen Rizos Group Leader Global Health & Social Head of Biomedical Sciences Gastrointestinal Cancer Medicine Faculty of Medicine and Health Program King’s College London Sciences Peter McCallum Cancer Centre UK Macquarie University Australia Australia Prof Eric Anslyn Dr Johannes Reynisson Distinguished Professor in Prof Bradley Smith Faculty of Science Chemistry Director, Notre Dame University of Auckland University of Texas at Austin Integrated Imaging Facility New Zealand USA Norte Dame University USA Ms Saskia Peters Prof Emma Kowal Practicum ARC Future Fellow Prof Andrew Webster Delft University of Technology Deakin University Sociology Department The Netherlands Australia University of York UK Mr Sander J Wezenberg Prof Jenny Reardon Practicum Director, Science & Justice A/Prof Jann Grimm University of Groningen Research Center Memorial Sloan Kettering The Netherlands University of California Cancer Center Santa Cruz, USA USA Dr Sherry Y Wu University of Texas M.D. Prof Wolfgang Schuhmann A/Prof Albert Folch Anderson Cancer Center Chemistry Department Bioengineering (MDACC) Bochum University University of Washington USA Germany USA Prof Benjamin G Davis Prof Daohan Ge A/Prof Krishna K Darodaran Chemistry Department Distinguished Professor Supramolecular Chemistry Oxford University Jiangsu University Group UK China University of Iceland Iceland

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Mr William Whitehouse Ms Anna Wang Dr Andrew Surman Practicum PhD Candidate Chemistry Department Imperial College London Harvard University University of Glasgow UK USA UK

A great talk by our international visitor A/Prof Jan Grimm from MSKCC in NYC on 13 Nov: “When particles meet...”

Biomedical Futures: Social Scientists engaging with big questions about science

National Science Week provided an opportunity for Dr. Declan Kuch, Dr. Georgia Miller and A/Prof Matthew Kearnes to engage with laboratory scientists, researchers and policy-makers around their research into the construction and implications of precision and targeting in biomedicine. Their work involves both ethnographic research of the science in the making and the broader policy landscape. These overlaps between science and policy have become increasingly visible in the push to engage publics in the making of various biobanks, such as the ‘All of US’ initiative.

Professor Jenny Reardon (UCSC) made an outstanding keynote lecture Just Biomedical Research based on her most recent book The Postgenomic Condition. Drawing inspiration from Arendt’s original formulation of human condition, Professor Reardon powerfully argued that simplistic narratives that genomic science - and precision medicine - will produce new cures and miracle drugs obscure harder questions about not only the meaning of genomic data but also how and by whom decisions about who lives and dies should be made.

(Photo Above: A/Prof Matthew Kearnes welcoming panel members. Prof Jenny Reardon from UCSC, 4th from left)

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Research Highlights

Concept illustration of multiuser virtual reality visualisation of nanoparticle distribution in vivo. Image: A/Prof John McGhee, Dr Andrew Lilja (UNSW Art & Design)

14 Prof Maria Kavallaris receives her 2017 NSW Premier's Prize for Science and Engineering from NSW Premier

2017 Grant Funding

ACN members’ total research funding for projects commencing in 2017 is approx. $11.5 million. Below is a list of 2017 new funding highlights.

ARC Discovery Project pancreatic cancer. (2017-2018). 2019). $150,000 DP170102727, Katharina Gaus, et $100,000 al. DNA nanotechnology for Department of Industry, controlled antigen presentation to Cancer Australia Priority-driven Innovation & Science, Innovation T cells. (2017-2019). $485,500 Collaborative Grant APP1126738, Connections Contracts, Pall Phoebe Phillips, Joshua Thordarson. (2017-). $50,000 ARC Discovery Project McCarroll, et al. Therapeutically DP170103599, Katharina Gaus, et Targeting a Solute Carrier Industry funding, Inventia, Maria al. Statistical analyses for spatial Transporter in the Stroma of Kavallaris. (2017-). $150,000 organisation in T cell signalling Pancreatic Cancer. (2017-2020). networks. (2017-2019). $398,500 $511,000 Lleaf Pty Ltd, ARC Linkage Partner Contribution, Pall Thordarson. ARC Linkage Project LP170100623, Cancer Australia Priority-driven (2017-). $37,500 Justin Gooding, Maria Kavallaris, Collaborative Grant APP1126736, et al. Bioinks for the 3D printing of Phoebe Phillips, Joshua NHMRC Principal Research cells made from off-the-shelf McCarroll, et al., Reprogramming Fellowship APP1119152, Maria components. (2017-2019). the tumour microenvironment Kavallaris. Precision $416,287 with the use of nanomedicines for nanomedicine-based cancer the treatment of pancreatic therapeutics. (2017-2021). ARC Linkage Infrastructure, cancer. (2017-2020). $500,000 $763,845 Equipment and Facilities LE170100087, Richard Tilley, et al. Cancer Council NSW, Katharina NHMRC Project Grants Plasma-focused ion beam for Gaus, et al. T cell receptor (TCR) APP1129609, Katharina Gaus. characterisation of signaling in adoptive T cell therapy Regulation of the signalling materials. (2017). $1,100,000 against B cell lymphoma. (2017- efficiency of the T cell antigen 2019). $450,000 receptor. (2017-2019). $456,557 ARC Industrial Transformation Training Centres Scheme Cancer Institute NSW Research Ovarian Cancer Foundation, Maria IC170100020, Pall Thordarson, Equipment Grant REG171128, Kavallaris. Re-activating anti- Richard Tilley, et al. ARC Training Maria Kavallaris. Ultra-fast, high tumour immunity by targeting N- MYC-Let7 axis in ovarian cancer. Centre for the Chemical resolution, low-dose (2017-). $126,000 Industries. (2017-2021). microcomputed tomography for $3,279,502 cancer and vascular imaging in Public section grant, NSW State small animals. (2017-) $383,100 Government for the New South Avner Pancreatic Cancer Wales Smart Sensing Network, Foundation Innovation Grant, CINSW Career Development Justin Gooding (2017-).$1,700,000 Phoebe Phillips, Joshua Fellowship, Orazio Vittorio. An McCarroll, et al. Therapeutically anticancer chemically-modified Tianjin Sungene Biotech Co Ltd, targeting a solute carrier natural compound targeting ARC Linkage Partner Contribution, transporter in the stroma of copper in neuroblastoma. (2017- Pall Thordarson. (2017). $50,000

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Tour de Cure Established Research Joshua McCarroll, et al. Targeting treatment of neuroblastoma. Grant, Phoebe Phillips, Joshua muty-homolog to reduce (2017-2018). $80,000 McCarroll, et al. Nanomedicine- pancreatic tumour UNSW-Tsinghua Collaborative based treatment to inhibit chemoresistance and metastatic Research Fund, Zi (Sophia) Gu, pancreatic cancer growth and spread. (2017-2018). $80,000 Cyrille Boyer, Maria Kavallaris. metastases. (2017-2018). Engineering a biodegradable $200,000 Tour de Cure Pioneering Cancer nanorobot for advanced therapies Research, Maria Kavallaris. and diagnosis. (2017-2018). Tour de Cure Pioneering Cancer Precision nanomedicine for the $15,000 Research Grant, Phoebe Phillips,

(Left: Dr Sophia Gu with Tsinghua Seed Fund collaborators.

Right: A/Prof Phoebe Phillips winner of Avner Pancreatic Cancer Grant)

Interdisciplinery Projects Currently Carried out at the Centre

Title of interdisciplinary projects Disciplines represented Isolating, interrogating and bioengineering single circulating cells Chemistry, cell biology JTCC: Visualising bio-imaging and data in 3D Virtual Reality (VR) Chemistry, Medical research, Biology, Data Science Nano challenges and opportunities in cancer Chemistry, cell biology, cancer biology Sensors and diagnostic for managing bloodstream infections Chemistry and Cell Biology Social dimension of bio-nano interactions Chemistry and Social Sciences MiRNA Detection Chemistry, cell biology, cancer biology Opendatafit Chemistry, Medical research, Biology, Data Science Gels as 3D cell culture materials Chemistry, Medicine, Cell Biology, Biomedical Engineering Folding of quaternary proteins Chemistry, Biophysics Aesthetics and drug delivery Chemistry and Social Sciences Facetet polymersomes for drug delivery Chemistry, Medicine, Cell Biology 3D printing of cells Cell biology, polymer chemistry, mechanical and electrical engineering Surfaces for cell capture and release Chemistry, cell biology, cancer biology

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2017 Newly Funded Projects

Precision Nanomedicine-Based simple method for creating Statistical Analyses for Spatial Cancer Therapeutics complex, multiple-cell-type three- Organisation in T Cell Signalling dimensional (3D) cell cultures for Networks M Kavallaris (NHMRC Senior in-vitro cell based assays. Using 3D Research Fellowship) printing technology, this project K Gaus, et al. (ARC Discovery will develop a versatile polymer Project) Cancer remains a significant system, made from entirely clinical problem and causes This project aims to reveal how commercially available considerable morbidity and nanoscale spatial organisation components, that gels upon mortality in society. Prof Maria encodes plasticity in the T cell printing and has functionality to Kavallaris is an international signalling network, and how T assist cells in adhering, growing leader in cancer biology, therapy cells exploit this plasticity to and migrating. The 3D printing of and the development of less toxic regulate sensitivity to antigens. In multiple cell types will provide therapies for cancer using adoptive immunity, T cells biological scientists with more nanotechnology. Her vision is to respond appropriately to any realistic in-vitro cell assays to build a leading program of applied given antigen, but how they make those found in-vivo. Applications research to develop treatments decisions is unclear. This project of the research are in cell biology, for aggressive disease that will will define how nanoscale spatial studying diseases and developing reduce the impact and improve organisation of signalling new drugs. the outcomes for cancer patients. molecules shapes signalling

strength and plasticity in the T cell DNA Nanotechnology for Regulation of the Signalling antigen receptor (TCR) network; Controlled Antigen Presentation Efficiency of the T Cell Antigen and infer rules linking spatial to T Cells Receptor organisation and signalling K Gaus, et al.(ARC Discovery activities in intact T cells. K Gaus (NHMRC Project Grants) Contextualising the TCR signalling Project) network is expected to reveal the An immune response starts with The project aims to present origin and use of network activation of the T cell antigen individual antigens to T cells and plasticity for T cell decision- receptor (TCR). How T cell to image T cell receptor signalling making. Such information could receptor signalling begins, with single molecule microscopy. be invaluable for the design of however, is not well understood. Combining DNA origami vaccines and immune-modulating We have developed a novel nanotechnology with single drugs. imaging approach that allows us molecule imaging should reveal to directly observe what happens the sensitivity of T cell signalling. A Plasma-Focused Ion Beam for after an antigen binds to the DNA force sensor will determine Nanoscale Characterisation of receptor. The research will whether mechanical forces Materials provide mechanistic insights into contribute to antigen how T cells sense and discriminate discrimination. The project will R Tilley, et al. (ARC Linkage Grant) antigens. This knowledge will aid use the nanotechnology strategy the development of cancer This project aims to enable to identify antigen-specific T cells immunotherapies and vaccines. research programmes in in tissue. The project is expected functional materials to to advance understanding of T cell characterise materials using Bioinks for the 3D Printing of biology, and contribute to DNA xenon-plasma focused ion beam Cells Made from Off-the-shelf nanotechnology and super- (FIB) instrumentation. The plasma Components resolution microscopy whilst FIB, with its fast milling speeds providing fundamental insights J Gooding, M Kavallaris, et al. across large areas, will enable new into antigen recognition by T cells (ARC Linkage Projects) three-dimensional imaging and ultimately derive clinically experiments and types of This project aims to develop a relevant practical applications.

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transmission electron microscopy Beatson Institute (Glasgow, Z Gu, M Kavallaris, C Boyer, et al. samples. This will have Scotland) and a clinical oncologist (Tsinghua Seed Fund) applications in engineering, from Prince of Wales photovoltaics and environmental Hospital/UNSW. Magnetic resonance imaging geosciences, which all need to (MRI) is currently one of the most analyse materials on a nanometre Therapeutically Targeting a powerful non-invasive molecular scale. Solute Carrier Transporter in the imaging techniques for cancer Stroma of Pancreatic Cancer diagnosis by providing anatomical Metabolically Reprogramming images of tissues and organs with the Stroma to Starve Pancreatic P Phillips, J McCarroll, etc. (Avner excellent spatial resolutions. The Tumours Pancreatic Cancer Foundation diagnostic capabilities of MR innovation grant) imaging can be greatly improved R Phillips, J McCarroll, etc. by introducing exogenous contrast (Cancer Australia grant) Pancreatic cancer (PC) claims five agents (T1 or T2 weighted Australian lives daily, with little contrast agents) to enhance targe This new project funded by the improvement in patient survival in tissue contrast through altering NHMRC will develop a novel 40 years. Targeting PC cells alone the relaxation time of nearby cutting-edge gene therapy and has failed. Pancreatic tumours are water protons. Dual-mode MR gene therapy delivery vehicle surrounded by extensive scar imaging has been explored to (nanomedicine) to metabolically tissue, which inhibits drug delivery address the issues on single-mode starve pancreatic tumours by and increases tumour growth. Our MR imaging by combining T1 and tackling stromal cells in the novel nanomedicine may be a T2 weighted contrast agent into tumour microenvironment. This therapy to breakdown this scar. one nanoplatform. The project project involves a multidisciplinary aims to develop a new dual-mode collaboration with chemists at the MRI contrast agent with high Magnetic Layered Double Australian Centre for selectivity, superb relaxivity and Hydroxide Nanoparticles as Dual- NanoMedicine, biologists from desirable biocompatibility. The mode Magnetic Resonance UNSW Sydney/Sydney project is a collaborative project Imaging Contrast Agent University/Cancer Research UK with Tsinghua University, China.

(Photo: Dr Vittorio takes visitors on a tour of the lab and explains his research)

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High Impact Papers

Selected publications by Professors and have been named among top 100 papers in Australia by the Royal Australian Chemical Institute Centenary Congress.

Paper-Based Sensor for Monitoring Sun Exposure Parisa S. Khiabani, Alexander H. Soeriyadi, Peter J. Reece, and J. Justin Gooding ACS Sens., 2016, 1 (6), pp 775–780

Light Activated Electrochemistry: Light Intensity and pH Dependence on Electrochemical Performance of Anthraquinone Derivatized Silicon Ying Yang, Simone Ciampi, Moinul H. Choudhury, and J. Justin Gooding J. Phys. Chem. C, 2016, 120 (5), pp 2874–2882

Visible Light-Mediated Polymerization-Induced Self-Assembly in the Absence of External Catalyst or Initiator Jonathan Yeow, Odilia R. Sugita, and Cyrille Boyer ACS Macro Lett., 2016, 5 (5), pp 558–564

Selective Photoactivation: From a Single Unit Monomer Insertion Reaction to Controlled Polymer Architectures Jiangtao Xu, Sivaprakash Shanmugam, Changkui Fu, Kondo-Francois Aguey-Zinsou, and Cyrille Boyer; J. Am. Chem. Soc., 2016, 138 (9), pp 3094–3106

Aqueous RAFT Photopolymerization with Oxygen Tolerance Sivaprakash Shanmugam, Jiangtao Xu, and Cyrille Boyer Macromolecules, 2016, 49 (24), pp 9345–9357

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Selected Articles with Impact Factors >10

Hinde E; Thammasiraphop K; Duong 50, 1423 (IF = 20.268) Chem Int Ed Engl, vol. 56, pp. 8384 – HT T; Yeow J; Karagoz B; Boyer C; 8388 (IF=12) Gooding JJ; Gaus K, 2017, 'Pair S.J. Lam, E.H.H. Wong, C. Boyer, G.G. correlation microscopy reveals the Qiao (2017) Antimicrobial polymeric Liang, K.; Richardson, J. J.; Doonan, C.; role of nanoparticle shape in nanoparticles, Progress in Polymer Ju, Y.; Cui, J.; Caruso, F.; Mulet, X.; intracellular transport and site of drug Science, DOI: Falcaro, P. “Enzyme-coated metal- release', Nature Nanotechnology, vol. 10.1016/j.progpolymsci.2017.07.007. organic framework shell for 12, pp. 81 – 89 (IF=38.9) (IF = 28.0) synthetically adaptive cell survival” Angewandte Chemie International Wong CK; Mason AF; Stenzel MH; Von Krbek LK S; Schalley CA; Thordarson Edition 2017, 56, 8510. (IF = 11.994) Thordarson P, 2017, 'Formation of non- P, 2017, 'Assessing cooperativity in spherical polymersomes driven by supramolecular systems', Chemical Xu J; Fu C; Shanmugam S; Hawker CJ; hydrophobic directional aromatic Society Reviews, vol. 46, pp. 2622 – Moad G; Boyer C, 2017, 'Synthesis of perylene interactions', Nature 2637 (IF=38.6) Discrete Oligomers by Sequential PET- Communications, vol. 8 (IF=12.1) RAFT Single-Unit Monomer Insertion', Doonan, C.; Ricco, R.; Liang, K.; Angewandte Chemie International Laos AJ; Dean JC; Toa ZS D; Wilk KE; Bradshaw, D.; Falcaro, P. “Metal-organic Edition, vol. 56, pp. 8376 – 8383 (IF= Scholes GD; Curmi PM G; Thordarson P, Frameworks at the Bio-interface: 2017, 'Cooperative Subunit Refolding of 11.5) Synthetic Strategies and Applications.” a Light-Harvesting Protein through a Accounts of Chemical Research 2017, Self-Chaperone Mechanism.', Angew

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Engagement & Activities

ACN Directors Prof Justin Gooding, Maria Kavallaris, Cyrille Boyer and Conference co-Chair Prof Richard Tilley with NSW Minister for Health and Minster for Medical Research, the Hon. Brad Hazzard MP

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Awards, Honours and Achievements

Professor Justin Gooding was awarded the prestigious UNSW Enterprise Award for Engagement for his Sun Patch, Sun Exposure Sensor in Nov 2017. The invention uses innovative technologies to create cheap, printable and easy-to-use sun exposure sensor stickers, which indicate to the wearer when they should seek shade or apply more sunscreen. By using off-the-shelf components and existing technologies, the invention has the potential to be widely deployed, maximising the benefit to society.

(Photo: NSW Minister for Innovation and Better Regulation Matt Kean with Enterprise Award for Engagement winner Professor Justin Gooding)

Professor Justin Gooding was awarded the Katsumi Niki Prize for Bioelectrochemistry of the International Society of Electrochemistry, for his creative and truly innovative contributions in areas of bioelectrochemistry such as peptide-based electrodes, DNA biosensors, "wiring" of enzymes to electrodes, antifouling coatings, disposable electrodes with low detection limits of hyphenated methods for detecting cell response to therapeutics. The prize is awarded every two years to a scientist who has made an important contribution to the field of bioelectrochemistry.

Professor Maria Kavallaris, of the Children’s Cancer Institute, won the award for Leadership in Innovation in New South Wales.

She is an internationally recognised authority in cancer biology research and nanomedicine therapeutics. She has made seminal contributions to the understanding of both the actions of anti-cancer agents and how resistance is developed against them.

(Photo: Prof Maria Kavallaris receives her 2017 NSW Premier's Prize for Science and Engineering from NSW Premier)

Professor Cyrille Boyer has received numerous national and international awards, including from the National High-end Foreign Experts Recruitment Project by the P.R. of China. Cyrille was appointed Honorary Professor at Beijing University of Chemical Technology in 2017.

Cyrille is a leader in his field of polymer chemistry, with a focus on pioneering practical, industry-relevant solutions to globally important problems.

Dr Alex Donald has been recognised as an Emerging Investigator in the field of mass spectrometry research in April 2017 issue of the Journal of the American Society of Mass Spectrometry – the official society journal, and the leading specialty journal in mass spectrometry research. Donald’s research was also selected for the cover of the April issue, which features high quality and interdisciplinary research communications contributed by the 14 researchers identified as rising stars in this field. This is the first year that an Australian- based researcher has been selected as an Emerging Investigator by the Journal of the American Society of Mass Spectrometry.

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Ms Aria Ahmed-Cox completed her honours at the Kavallaris lab in 2017. She was awarded a 1st class honours and a University medal. She has since received a prestigious UNSW Scientia PhD scholarship to study with Maria Kavallaris and A/Prof John McGhee.

Her project is entitled “Cancer Nanomedicine: Visualisation and Efficacy of Nanoparticle Delivery”. The aim of Aria’s project, which will bring together expertise from multiple disciplines including Medicine, Engineering, Chemistry and Art & Design, is to optimise nanoparticles as drug transporters to deliver drugs directly to cancer cells, without harming normal cells.

Aria will work with A/Prof John McGhee to create an interactive virtual reality 3D model of her nanoparticles entering cancer cells. This is possible thanks to an ongoing collaboration between Prof Kavallaris and A/Prof McGhee. Third year PhD student Manish Sriram from Justin Gooding’s group, was selected to represent UNSW at the Global Fellows Program in Germany on “Cities of the Future” during the European summer (from 17–21 July). This is a new initiative of Global Alliance of Technological Universities to help students from all disciplines develop the professional, research and collaborative skills needed to develop solutions for the challenges facing cities of the future. During this summer school, the students will meet with the Mayor of Burghausen and city planners to pitch their ideas for improving the management of issues, including infrastructure and healthcare, of expanding urban populations.

Ms Helen Forgham is a PhD student jointly supervised by Prof Maria Kavallaris and Dr Joshua McCarroll. Helen won the Tow Award in Nov 2017. The prize includes $1000 Award, Inscribed medal and hardbound set of volumes including past prizewinning entries plus Travel Grant: Up to $3000 will be available for travel to an international conference occurring outside of Australia, and up to $2000 for a conference (international, national, or local) occurring within Australia. Congratulations, Helen!

(Photo: Helen Forgham receiving the Tow Award)

PhD student Morphy Dumlao takes home the prize for best student talk from the 26th Australian and New Zealand Society for Mass Spectrometry (ANZSMS) Conference held at Flinders University, Adelaide, 16 – 20 July.

Dumlao presented his winning talk entitled “Solid-phase microextraction dielectric barrier discharge ionisation for mass spectrometry” at the biennial conference, which brings together local and international researchers working with mass spectrometry. (Photo: Morphy Dumlao with supervisor Alex Donald)

Ms Susan Oliver won the prize for Best Presentation at UNSW Engineering Postgraduate Research Symposium held 26-29 September 2017.

Susan commenced her PhD in March 2015 working with Professor Boyer. Her work involves developing new methods of using natural polymers to stabilise and deliver therapeutic molecules

(photo: Susan Oliver (right) receiving the prize for Best Presentation)

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Ms Angelyn Wu is a Taste of Research (ToR) student under Dr Zi (Sophia) Gu’s supervision. Angelyn won the first prize in the Faculty ToR Showcase.

Angelyn is currently a 3rd year Chemical Engineer. Her ToR project was focused on Researching polymer coatings in order to stabilize nanoparticles for bio- applications.

(Photo: Angelyn Wu (right) with supervisor Dr Sophia Gu)

Scientia Professor Justin Gooding Professor Cyrille Boyer Dr Damia Mawad  UNSW Innovation Enterprise Award  Visiting professor appointment  Best Lecture prize for her invited for Engagement at Beijing Chemical Technology talk, “A sutureless conductive  Bertram Dillon Steel Lectureship University patch for enhancing the cardiac from University of Queensland  Eureka Prize finalist for electric signal”, in the Laser School of Chemistry Scientific Research Florence 2017, 29th  Australian Museum Eureka Prize for International Congress Laser Outstanding Mentor of Young Professor Pall Thordarson Medicine, 9-11 Nov2017 Researchers  Fellow of the Royal Australian  Katsumi Niki Prize in Chemical Institute Ms Raheleh Pardehkhorram Bioelectrochemistry from the  Fellow of the Royal Society of (PhD student, Gooding group) International Society of Chemistry UK  Small Award for Best oral Electrochemistry presentation by a PhD student A/Prof Phoebe Phillips th  Special Commendation, Australian at 8 International Council for Graduate Research  Dean's Award for Research Nanomedicine Conference, 3-5 Award for Excellence in Promoting Excellence Jul 2017 Industry Engagement in Graduate  Invited member of NHMRC Research Assigners Academy for Project Mr Jonathan Wojciechowski Grants 2018 (PhD student, Thordarson Group) Professor Maria Kavallaris  Promoted to Deputy Director of • Poster prize, 8th International  NSW Premier’s Science and the Adult Cancer Program, Lowy Nanomedicine Conference, 3-5 Engineering Award for Leadership in Cancer Research Centre, UNSW Jul 2017 Innovation 23rd October Sydney  Invited Judge, 2017 Australian Ms Susan Tan Museum Eureka Awards Dr Jason Xu (PhD student, Thordarson group)   2017 Fellowship Selection Listed as “Emerging  Poster prize, 8th International Committee, Australian Academy of Investigator” by Polymer Nanomedicine Conference, 3-5 Health and Medical Sciences Chemistry and Chemical Jul 2017 Communications  Member, NHMRC Research Committee  Visiting Academic to Nagoya Ms Anouschka Akerman University (NU) under the  Chair, NHMRC Population Health (PhD student, Phillips group) Panel Japanese Global COE program  Campion-Ma-Playoust Memorial  Award for best oral presentation Chair, NHMRC Project Grant Panel Dr Sophia Gu at ASMR national conference  Monash Engineering Women's Leadership Award

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Editors of Journals

Scientia Professor Justin Gooding  Member of the editorial Professor Cyrille Boyer  Editor-in-Chief, ACS Sensors advisory board of the ACS  Associate Editor for RSC journal, Bioconjugate Chemistry Advances 2015-Aug 2017  Member of the editorial board (Handling) of the American 2014-present  Guest Editor for Scientific Publishers Journal of  Member of the editorial board Macromolecular Rapid Chemical and Biological of the Wiley-VCH journal, Communication Interfaces 2013-present Chemistry – A European Journal  Guest Editor for 2014-present International Journal of  Member of the editorial board Polymer Sciences of the Elsevier journal  Member of the editorial board  Member of the editorial Electrochemistry of the MDPI journal, board of Biomacromolecules Communications 2003-present Nanomaterials 2015-present 2017-present  Member of the editorial board  Member of the editorial of the Humana Press journal board of Macromolecular Nanobiotechnology 2005- Professor Maria Kavallaris  Editorial Board Member Rapid Communication 2017- present present Nanomedicine NBM  Member of the editorial board  Member of the editorial of the Wiley journal, board of Macromolecular Electroanalysis 2006-present Physics Chemistry 2017-  Member of the editorial board Scientia Prof Katharina Gaus present of the Elsevier journal Sensors  Biophysical Journal 2013-  Member of the editorial and Actuators B 2008-present present board of Polymer Chemistry  Member of the advisory  PLoS ONE 2011-present 2017-present editorial board of the Royal  Biochemical Journal 2004-  Member of the editorial board of Polymer Society of Chemistry journal, present Chemical Sciences 2010-present International 2017-present  Member of the editorial board

of the MDPI journal Biosensors A/Prof Matthew Kearnes 2010-present Professor Pall Thordarson  Member of the editorial board  Member of the editorial board  Associate Editor of Australian of Science, Technology and of the Wiley-VCH journal, Journal of Chemistry ChemElectroChem 2013-present Society (Sage)

8th International Nanomedicine Conference: Mr Jonathan Wojciechowski & Ms Susan Tan, PhD students from Thordarson Group, received the Mark Wainwright Analytical Centre and ACS Journals poster prizes. Ms Raheleh Pardehkhorram, PhD student from Gooding group received the Small Award for best oral presentation by a PhD

student. 25

Eureka!

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Media

The ACN researchers are dedicated to reaching out beyond the scientific community and have engaged in various television, radio, newspaper, magazine and online interviews; and contributed to newspaper articles and online blogs to promote the Centre and its research. The following list provides a glimpse of the Centre’s extensive media engagement.

P.S. Khiabani, A.H. Soeriyadi, P.J. - ABC Radio News, New stick-on - UNSW Newsroom, A wearable Reece, J.J. Gooding, A Paper Based patches indicate when it's time to sunburn sensor!, 2/11/2017 Sensor for Monitor Sun Exposure, ACS get out of the sun, 1/2/2017 Sensors 1 775-780 (2016). Justin Gooding Eureka Prize - World News Network, Sydney Selected media coverage Continuing on from the huge media scientists invent skin patch that interest generated from the above can prevent sunburn, 1/2/2017 - UNSW Newsroom, 2017 Eureka named paper published in 2016, there Prize finalist for Outstanding are further numerous media reports in - Brisbane Times, Sydney scientists Mentor of Young Researchers, 2017 featured in: invent skin patch that can prevent 28/07/2017 sunburn, 1/2/2017 - The Age - UNSW Newsroom, Eureka Prizes - WA Today - NSS Smart Sensing Network, for outstanding science mentor - Canberra Times Sydney scientists invent skin patch and world-first trials, 31/08/2017 - Brisbane Times - Warrnambool Standard that can prevent sunburn, - Hills News 31/01/2017 - ABC News, Eureka Prize winners - The Border Mail show off Australian-grown science - Central Western Daily - Western Advocate, Sydney ingenuity, 31/08/2017 - Bussleton Times scientists invent skin patch that - The Advocate can prevent sunburn, 1/2/2017 - Business Insider, 2017 Eureka - Newcastle Herald - Wagga Wagga Daily Prizes, 30/08/2017 - Redland City Bulletin - Lithgow Mercury, Sydney scientists - Bendigo Advertiser invent skin patch that can prevent - Open Gov, NSW Smart Sensing - Southern Weekly sunburn, 1/2/2017 Network launched to develop - Northern Daily Leader portable, smart sensors for health, - The Area News - Daily Liberal, Sydney scientists - Blayney Chronicle environment, 28/10/2017 invent skin patch that can prevent - Great Lakes Advocate and - 47 other local papers sunburn, 1/2/2017 - Australian Academy of Science, Academy Fellow wins Eureka Prize Selected media coverage: - Mudgee Guardian, Sydney for mentoring young researchers, scientists invent skin patch that 7/9/2017 - 7News, Sun-sensing 'smart' paper can prevent sunburn, 1/2/201 promises new shield against Aussie sun, 1/2/2017 - ABC News, Smart sun sensor lets you know when you're - SMH, Sydney scientists invent skin cooked,29/08/2017 patch that can prevent sunburn, 1/2/2017 - National Geographic, New Sticker Will Let You Know When You’re - ABC News, ABC AM interview with Cooked, 31/08/2017 Justin about the UV patch, 1/2/2017

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Maria Kavallaris - oKosmos - Greek language - UNSW Newsroom, Virtual reality newspaper, Title is in Greek allows multiple scientists to ‘walk’  Page 5, 17/10/2017 through cancer cells, 19/12/2017  Page 5, 24/10/2017  Page 2, 25/10/201 - ABC News, Virtual reality lets  Pages 1&9, 27/10/2017 scientists walk around inside

cancer cells, set to revolutionise - Children’s Cancer Institute medicine , 19/12/2017 Online News, Our science stars

shine, 25/10/2017 - ABC News, ABC interviews A/Prof

John McGhee about the potential

- ABC Radio News, Meet three of VR to revolutionise health Cyrille Boyer scientists finding cures for education, 19/12/2017

childhood cancer at the Children's Cancer Institute, 31/03/2017 - ABC Perth Radio News, University of New South Wales is combining - The Conversation, Explainer: what 3D Gaming technology, is nanomedicine and how can it 19/12/2017 improve childhood cancer treatment? 23/05/2017 - Adelaide News, Researchers from the University of New South Wales - UNSW Newsroom, UNSW have created a futuristic way of

researchers win Premier's Awards, scanning and identifying cancer - Ingenuity, Molecular Warfare, 22/10/2017 cells, 19/12/2017 Page 30, 29/5/2017

- Domain News, House that love - ABC TV, 3D gaming technology - Ingenuity, Polymath of Polymers, built snapped up for $700000, all could revolutionise cancer Page 31, 29/5/2017 going to ..., 22/10/2017 treatment, 19/12/2017

- Science meets Business, Molecular - Online News 9 Honey, House sale - ABC TV, Researchers from the warfare, 24/8/2017 makes $700k for children's cancer University of New South Wales

charity, 23/10/2017 have created a futuristic way of - UNSW Newsroom, Boyer scanning and identifying cancer Laboratory - finalist, Eureka Prize - Online News Children’s Cancer cells, 19/12/2017 for Scientific Research, 28/7/2017 Institute, Childhood cancer

leader’s star on the rise at NSW - UNSW TV, Multi-user VR opens - UNSW Newsroom, Green polymers Premier’s Science and Engineering new worlds for medical research, and instructive clouds: new Prize, 23/10/2017 11/12/2017 Professors look ahead, 1/11/2017

- SBS TV, The life-long effects for - Lab Online, VR allows scientists to

childhood cancer survivors, 'walk' together through cancer John McGhee (& Maria Kavallaris) 23/10/2017 cells, 20/12/2017

- SBS, Australian professor wins - Science Daily, Virtual reality allows prestigious prize for effects of you to look inside your body and childhood cancer, 24/10/2017 could help improve drug delivery, 21/11/2017 - Wentworth Courier , Professor’s honour for helping children, Page

31, 25/10/2017

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Phoebe Phillips Orazio Vittorio Matthew Kearnes, Declan Kuch, Robert Utama & Palli Thordarson

- The Sydney Morning Herald , NSW

- NHMRC in Focus, Cancer research government funds search for new

breakthrough reduces pancreatic cures for childhood cancer, - Radio ABC, The man in a dress: tumour growth, 24/1/2017 15/02/2017 who were the real luddites?

17/8/17 - Laboratory Equipment Magazine, - SBS News, Scientists on track to

The Promise of Nanomedicine, find less toxic treatments for

13/11/2017 childhood cancer, 10/08/2017

- Last Post magazine, Promising - SBS Italy News, Dr Orazio ways to tackle the most deadly Vittorio's challenge to cancer, cancer, Issue 14, 2017 16/08/2017

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8th International Nanomedicine Conference

The 8th International Nanomedicine Conference was hosted by the ACN and chaired by Centre Co-Director Professor Maria Kavallaris, and Professors Richard Tilley and Nico Voelcker. The Conference took place at the Crowne Plaza, Coogee Beach from 3-5 July 2017. This is a key event in the nanomedicine research community and was attended by biologists, clinicians, chemists, material chemists and engineers from around the world.

The conference welcomed over 200 delegates from 17 countries. 5 plenary speakers, 11 keynote and 21 invited speakers led discussions in 8 conference theme areas. This year we had the great honour of welcoming NSW Minister for Health and Minister for Medical Research, the Hon. Brad Hazzard MP who officially opened the conference. Monday night saw the annual conference dinner where the Guest of Honour UNSW Dean of Engineering Professor Mark Hoffman delivered a short speech and shared his insights on nanomedicine.

48 ACN members, post-doctoral researchers, and PhD students attended the conference and presented their research including 10 oral presentations and 13 posters. Congratulations go to 3 of our PhD students who won the conference prizes: Mrs Raheleh Pardehkorram received the Small prize for Best PhD oral presentation; Mrs Susan Tan and Mr Jonathan Wojciechowski won the Mark Wainwright Analytical Centre and ACS Journals poster prizes. Special thanks go to our conference Support Committee team leaders Dr Robert Utama, Mr Manish Sriram, Dr Adam Martin and Dr Josh Peterson and our wonderful team of volunteers who helped make the event successful.

NSW Health Minister Brad Hazzard UNSW Dean of Engineering Professor Conference co-Chairs Profs attended and officially opened the 8th Mark Hoffman was Guest of Honour at Maria Kavallaris and Richard International Nanomedicine Conference. Conference Dinner. Tilley welcoming delegates.

Scientia Professor Justin Gooding Professor Justin Gooding thanking NSW Students from St. Aloysius’ delivering a Plenary talk “Cell based Health Minister Brad Hazzard for his College participated in poster diagnostic devices to explore therapeutic support of the Conference. judging session. action”.

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NanoMedicine Elevator Pitches

An elevator pitch is a succinct, persuasive speech to get your ideas and concepts across. The purpose of this event is to increase dialogue and encourage cross disciplinary research collaboration within ACN.

As part of our ongoing drive to develop emerging leaders and retain talents through workshops and providing postdoc and PhDs the opportunity to plan and host workshops, we launched the NanoMedicine Elevator Pitches event. Dr Adam Martin was actively involved in organizing and chairing this event. Adam is an NHMRC-ARC Dementia Research Development Fellow and joined the ACN in 2016. Members from 7 groups pitched their research to a panel of experts. Topics range from “Antimicrobial polymeric nanomaterials”, “Tumour-targeting peptide-drug conjugates” to “Is biomedicine a Ponzi scheme?”

Photos:

Above left: Packed room of audience

Bottom left: Panel Deliberations. The quality of presentations intensified deliberations

Above Right: CBNS Director Prof Tom Davis presenting Dr Orazio Vittorio with Directors’ Award for his presentation entitled: Targeting copper in neuroblastoma by using nano-modified natural compounds

Bottom Right: ACN Co-Director Prof Maria Kavallaris presenting Dr Rob Utama with People’s Choice Award for his presentation entitled: High throughput 3D cell culture at the push of a button

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Panel Discussion with ECRs

Drawing from the wealth of talent within ACN members, the ACN also organized a unique panel discussion, entitled: An ECR's Perspective on Obtaining Your First Fellowship. Six of our fully funded ECR fellows participated in the panel discussion. Dr Adam Martin put in great effort in the planning of this event. Dr Declan Kuch chaired the discussion.

The panel discussion is a great addition to our regular seminars. It once again gives our ECRs, postdocs and PhDs the opportunity to plan and chair panel discussion and seminar sessions, which all fits well into our top most strategic priority People/Talent.

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Seed Funding

ACN launched the seed funding program as a strategic initiative in 2015. The purpose of the program is to provide seed funding to ACN members to pursue research that can lead to future grant applications. One of the key requirements is that projects must involve collaboration between ACN members across two or more different groups.

The seed funding program has helped ECRs and students manage their own projects on a small scale and generate some results that they can use for their own grant applications in the future. It helped them forge new collaborations within ACN and put people with differing backgrounds in the same room to talk about how to tackle new problems together. A few papers have been generated with data produced from the seed funding projects, including one published in Angewandte Chemie as a VIP (very important paper); and data generated from another project was used in the successful application for an ARC discovery project.

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Selected Seed Funding Report

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Collaborating Organisations

Australian National University, University, Bangladesh Carl Gustav Carus, Germany Australia Federal University of Philipps Universität Marburg, Griffith University, Australia Maranhão, Brazil Germany

Macquarie University, Australia University of Campinas, Brazil University of Leipzig, Germany

University of Sydney, Australia University of Alberta, Canada University of Calabria, Italy

Victor Chang Cardiac Research University of British Columbia, Hebron University, Palestine Institute, Australia Canada CIC Biomagune, Spain Deakin University, Australia Linyi University, China University of Zaragoza, Spain Monash University, Australia Qingdao University, China University of Warwick, United University of Melbourne, Central China Normal Kingdom Australia University, China University of British Columbia, CSIRO Manufacturing, Australia University of Aix-Marseille, Canada France Curtin University, Australia Tianjin Sungene Biotech Co Ltd, Institut für Chemie und China Royal Perth Hospital, Australia Biochemie, Germany Freie Universität Berlin, University of Western Australia, University of Bremen, Germany Germany Australia Institute of University of Iceland, Iceland Queensland University of Radiopharmaceutical Cancer Technology, Australia Research, Germany Gifu University, Japan

University of Queensland Technische Universität Dresden Victoria University of Diamantina Institute, Australia and Helmholtz-Zentrum Wellington, New Zealand Dresden-Rossendorf, Germany ANSTO, Australia The University of Auckland, Leibniz Institute of Solid State New Zealand Australian Synchrotron, and Material Research Dresden, Australia Delft University of Technology, Germany The Netherlands RR Medsciences Pty Ltd, University Hospital Erlangen, Australia Imperial College, UK Germany Lleaf Pty Ltd, Australia University of Manchester, UK German Cancer Consortium Ettason Pty Ltd, Australia (DKTK) Dresden and German Princeton University, USA Cancer Research Center (DKFZ), Harvard University, USA Daffodil International Germany

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Presentations &Publications

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Presentations

The Centre puts great value on the knowledge shared and gained at conferences both local and international. The following is a list of selected talks, seminars and poster presentations in 2017.

Plenary/ Keynote (Financially supported) J.J. Gooding, R. Tavallaie, S.M. Silva, K. Chuah, Y.F. Wu, E. Presentations M. Kavallaris, “Nanoparticle Murago, D.B. Hibbert, R.D. Tilley, delivery for cancer therapy: Magnetic Nanoparticles as – Conferences and Design, uptake and efficacy”, 2017 Dispersible Electrodes, Mátrafüred, Symposia International Conference on Bio- Hungary 11-15 Jun 2017. Nano Innovation, Brisbane, 24 -27 (Financially supported)

Sep 2017. J.J. Gooding, “Nanotechnology and S.G. Parker, Y. Yang, S. Ciampi, J.J. Biosensors: From Detecting Small P. Thordarson, “Peptide gels for Gooding, Light Activated Molecules and Drugs to the 3D cell cultures”, 8th International Electrochemistry for the Capture, Monitoring of the Activity of Nanomedicine Conference, Electrochemical Interrogation and Whole Cells”, E3-Nano: Sydney, Australia, 3-5 Jul 2017. Release of Rare Cells, 9th International School and International Conference on Workshop on Nanotechnology, M. Kearnes, “The Challenge of Materials for Advanced Brisbane, Australia, 26-29 Sep Responsible Research and Technologies, Singapore 18-23 Jun 2017. (Financially supported) Innovation: Nanomedicine and 2017. (Financially supported)

Beyond”, 8th International J.J. Gooding, M. Parviz, S. G. Nanomedicine Conference, M. Kavallaris, “Cancer Parker, R. Utama, E. Hinde, Y. Sydney, Australia, 3-5 Jul 2017. nanomedicine: drug delivery and Yang, L. Atapattu, S. Ciampi, M. beyond to solid tumours” The Kavallaris, K. Gaus, “Cell based Lorne Cancer Conference, diagnostic devices to explore Melbourne, 9-11 Feb 2017. therapeutic action”, 2017 Invited Talks – (Financially supported) International Conference on

BioNano Innovation, Brisbane, Conferences and M. Kavallaris, “Nanotechnology Australia. 24-27 Sep 2017. Symposia for Cancer Therapy”, 34th (Financially supported) Combined Health Science

Conference, Centenary Institute, J.J. Gooding, M. Parviz, S.G. J.J. Gooding, S.G. Parker, Y. Yang, Royal Prince Alfred Hospital, Parker, R. Utama, E. Hinde, Y. M.B. Kashi, V.R. Gonçales, S. Camperdown, Australia, 20-21 Nov Yang, L. Atapattu, S. Ciampi, M. Ciampi, Light activated 2017. Kavallaris, K. Gaus, Cell based electrochemistry for the capture, diagnostic devices to explore electrochemical interrogation and C. Boyer, J. Xu, “Design of therapeutic action, 8th release of single cells, Pittcon functional polymer using visible International Nanomedicine 2017, Chicago, USA, 5-9 Mar 2017. light”, RACI National Conference, Conference, Sydney, Australia, 3-5 (Financially supported) Melbourne, Jul 2017. Jul 2017. (Financially supported)

Y.H. Zheng, K. Chuah, Y.F. Wu, X. Lu, X.Y. Cheng, P. Nicovich, K. C. Boyer, “Precision polymer M. Kavallaris, “New Drugs-New synthesis using visible light”, ACS Gaus, J.J. Gooding, Towards Single Thinking: Potential of Conference, Washington, USA, 19- Nanotechnology to Advance Molecule Sensors, Pittcon 2017, 24 Aug 2017. Cancer Drug Delivery”, Menzies Chicago, USA, 5-9 Mar 2017. Health Institute Queensland, (Financially supported) K. Gaus, “Super-resolution and Griffith University, 16 Jun 2017. single molecule science”, The 28th 37

New Zealand Conference on Pisa, Italy, 1-2 Dec 2017. community engagement for Microscopy, Auckland, New (Financially supported) philanthropy: A researcher’s Zealand, 31 Jan - 3 Feb 2017. perspective”, Avner Pancreatic O. Vittorio, M. Kavallaris. “In vivo Cancer Foundation Symposia, 64 K. Gaus, “Single Molecule [ Cu]CuCl PET imaging reveals Sydney, Australia, 16 Nov 2017. Membrane Protein Dynamics” 2 activity of copper-targeting Biophysical Society 61st Annual P. Phillips, “Therapies personalised anticancer drug”. Cancer Meeting, New Orleans, Louisiana, to the stroma in pancreatic Nanotheranostics, University of USA, 11-15 Feb 2017. cancer”, Australian Sydney, 6 Dec 2017. (Financially Gastroenterology Week (AGW), supported) K. Gaus, “T cell receptor clustering Gold Coast, Australia, 20-22 Aug

– a mechanism of signal 2017. J. McCarroll, “Development of transduction”, 2017 Hunter Cell gene-silencing nanomedicines for Biology Meeting, Lovedale, NSW, P. Phillips, “Nanomedicine as a the treatment of cancer”, Imaging Australia, 3-7 Apr 2017. therapy to target ‘undruggable’ to Innovate UNSW Sydney, Jul genes in pancreatic cancer”, 2017. K. Gaus, “T Cell Receptor Australian Gastroenterology Week

Clustering – A Mechanism of Signal (AGW), Gold Coast, Australia, 20- K. Liang, "Synthetic Transduction”, Molecular 22 Aug 2017. biominerlization of metal-organic Membrane Biology Gordon frameworks" Collaborative Research Conference, Proctor P. Phillips, “Novel Therapeutic Conference on Materials Research Academy, USA, 16-21 Jul 2017. Targets in Pancreatic Cancer”, (CCMR), Jeju, Korea, Jun 2017. Adult Cancer Program Seminar

O. Vittorio, M. B. Brandl, G. Cirillo, Series, Lowy Cancer Research K. Liang, "Synthetic K. Kimpton, E. M. H. Yee, N. Centre, UNSW Sydney, 2017. biominerlization of metal-organic Kumar, M. Kavallaris. Nano- frameworks" Layer-by-layer (LbL) modified natural therapeutic P. Phillips, “Modulating Pancreatic 2017 Conference, Seoul National agents to target copper Tumours using RNAi based University, Seoul, Korea, Jun 2017. homeostasis in Neuroblastoma. Nanomedicines”, US-Australian

Nanotech France 2017, Paris, Emerging Cancer Biomedical K. Liang, "Metal-Organic France, 28 - 30 Jun 2017. Technologies Workshop held at Frameworks at the Surface of (Financially supported) Virginia Tech Research Center in Living Cells" Australian X-ray Arlington, Virginia, USA, Jun 2017. Analytical Association conference O. Vittorio, “Targeting copper (AXAA2017), Melbourne, Feb homeostasis as a therapeutic 2017. strategy for neuroblastoma”. The

Cancer Institute NSW Fellows’ P. Phillips, “Therapeutically Public Lectures, Forum 7 Sep 2017. (Financially targeting the stroma of pancreatic supported) Seminars – cancer”, Avner Pancreatic Cancer

Foundation Symposia, Sydney, O. Vittorio, “Being a young Universities and Australia, 16 Nov 2017. scientist in Australia: a job or a Societies lifestyle?”, ASMR NSW Early P. Phillips, PANEL: Q & A – World Career Development Day 19 Sep J.J. Gooding, “Sensing our World: Pancreatic Cancer Day: What does 2017. (Financially supported) From glucose sensors to counting the future look like? Avner single molecules and cells” Public Pancreatic Cancer Foundation G. Cirillo and O. Vittorio, Lecture: Royal Society of New Symposia, Sydney, Australia, 16 “Nanotechnology in cancer South Wales Liversidge Lecture, Nov 2017. therapy: where we are up to”. UNSW, 11 May 2017.

Italian Orthopaedic research P. Phillips, “Importance of society: Focus on Nanotechnology, J.J. Gooding, “Transforming 38

materials in new measurement Applications”, University of J. Xu, “Photo-induced Living devices using well-defined surface Science and Technology of China, 5 Polymerization for Green Polymer chemistry”, Science at the Shine Dec 2017. Synthesis”, Monash University, Dome 2017, Australian Academy of Melbourne, Australia, 18 Nov Science, Canberra, Australia, 23-25 C. Boyer, “Living radical 2017. May 2017. polymerisation”, University of South Australia, 14 Feb 2017. P. Phillips, “Novel Therapeutic J.J. Gooding, “Single Entity Targets in Pancreatic Cancer”, Sensors: From Detecting Many to C. Boyer, “Light regulated Adult Cancer Program Seminar Detecting One to Detecting Many”, polymerization for the synthesis of Series, Lowy Cancer Research Intelligent Polymer Research well-defined nanoparticles”, Case Centre, UNSW, 2017. Centre, University of Wollongong, Western University, USA, 2017 2 Jun 2017. P. Phillips, “The Future of K. Gaus, “What can single Pancreatic Cancer treatment: A J.J. Gooding, “Single Entity molecule localization microscopy Pre-clinical View from the Sensors: From Detecting Many to (SMLM) do for you?” Walter+Eliza Laboratory”, Translational Cancer Detecting One to Detecting Many”, Hall – Institute of Medical Research Network (TCRN; Cancer Public Lecture: University of Research, Australia, 27 Mar 2017. Institute NSW) Seminar Series and Queensland Bertram Dillon Steele Prince of Wales Hospital, Nov Lecture, 18 Sep 2017. K. Gaus, “T cell receptor clustering 2017. - a mechanism of signal”, Hudson M. Kavallaris, Keynote Speaker, Seminar Series, School of Clinical P. Phillips, “Scaling the Pancreatic “Twists and Turns on the Path of a Sciences at Monash Health, Cancer Mountain – Trust and Cancer Researcher”, Cure Cancer Australia, 27 Apr 2017. Teamwork”, Bridging the Gap Australia ECR Meeting, Melanoma Seminar Series, Translational Institute, Sydney, 16 May 2017. K. Gaus, “T Cell Receptor Cancer Research Network, UNSW, Clustering – a mechanism of signal 2017. M. Kavallaris, Special Guest transduction”, School Colloquia Speaker at OEEGA Ladies’ Series, Faculty of Science, UNSW, P. Phillips, “Chemoresistance in Committee Dinner Dance on 29 26 Sep 2017. Pancreatic Cancer using a Novel Apr 2017 to raise funds for Nanoparticle-siRNA Approach”, Children’s Cancer Institute. K. Gaus, “EMBL in Australia”, Anderson Stuart Research Seminar Garvan Institute of Medical Series, University of Sydney, 2017. M. Kavallaris, “Cancer Biology to Research, Australia, 9 Jun 2017. Nanomedicine-based P. Phillips, “Tackling Pancreatic Therapeutics”, Kidson Lecture, O. Vittorio, “Targeting copper Cancer using Nanomedicine”, QIMR Berghofer Medical Research metabolism by flavonoids: Nanoclinic Conference: Institute, Queensland, 6 Jun 2017. promising strategy for cancer Translational Cancer Research treatment”, School of Pharmacy, Network (TCRN), UNSW Sydney, C. Boyer, “Functional Polymers for the University of Calabria, 21 Jun 2017. Bioapplications”, Queensland 2017. (Financially supported) University of Technology (QUT), P. Phillips, “The New NHMRC Brisbane, 9 Jun 2017. O. Vittorio, A. Parmar, G. Pascali, Grant Structure – An Insider’s 64 M. Kavallaris. “[ Cu]CuCl PET View”, Shifting Funding Landscape C. Boyer, “Precision Polymer 2 in Australia; UNSW Sydney imaging for the evaluation of Synthesis for Advanced Symposia, 2017. anticancer activity of Dextran- Applications”, Hefei University of Catechin conjugate as a novel Technology, 4 Dec 2017. treatment for neuroblastoma”.

UNSW imaging workgroup/ C. Boyer, “Precision Polymer symposium talks, 5 Jun 2017. Synthesis for Advanced 39

Other Oral Porous Silicon Photonic Crystal: A. Ahmed-Cox, “Targeting copper Towards Single Cell Sensing”, homeostasis in glioblastoma using Presentations Pittcon 2017, Chicago, USA, 5-9 a chemically modified polyphenol”, Mar 2017. Lorne Cancer Conference, Y. Yang, S.G. Parker, S. Ciampi, J.J. Melbourne, 9-11 Feb, 2017. Gooding, “Light Activated S.M. Silva, R. Tavallaie, D.B. Electrochemistry for Single Cell Hibbert, J.J. Gooding, “DNA Y.F. Wu, K. Chuah, P.J. Reece, A.P. th Isolation and Analysis”, 8 Surface Hybridization: Micolich, J.J. Gooding, “Single- International Nanomedicine Electrochemical Investigation”, Molecule Detection of Proteins Conference, Sydney, Australia, 3-5 Pittcon 2017, Chicago, USA, 5-9 Based On Solid-State Nanopore Jul 2017. Mar 2017. Array Combined With Magnetic Nanoparticles As Capturing R. Utama, L. Atapattu, A. A. Martin, “Establishing neural Vehicles”, 8th International O’Mahony, J. Ribeiro, M. networks in peptide hydrogels”, 8th Nanomedicine Conference, Kavallaris, J.J. Gooding, “High International Nanomedicine Sydney, Australia, 3-5 Jul 2017. Throughput Production of Conference, Sydney, Australia, 3-5 Multicellular Spheroid Assays Jul 2017. A.J. McGrath, A.M. Henning, S. th Using 3D Bioprinting”, 8 Cheong, J.J. Gooding, R.D. Tilley, International Nanomedicine G. Duche, “Assessing the social “Seed-mediated synthesis of iron Conference, Sydney, Australia, 3-5 aspect of a novel drug delivery nanoparticles for biomedical Jul 2017. system used for topical application imaging”, 8th International in aesthetic therapy. A story of Nanomedicine Conference, M. Sriram, S. R. C. Vivekchand, P. collaboration between science and Sydney, Australia, 3-5 Jul 2017. R. Nicovich, R. D. Tilley, J.J. social science”, 8th International Gooding, “Digital biosensors for Nanomedicine Conference, A.D. Farahani, “The Role of th enhanced disease detection”, 8 Sydney, Australia, 3-5 Jul 2017. Aromatic Interactions in Self- International Nanomedicine Assembled Gels: Fluorinated Conference, Sydney, Australia, 3-5 Aromatic Capping Groups”, 8th Jul 2017. International Nanomedicine Poster Presentations Conference, Sydney, Australia, 3-5 R. Pardehkhorram, Y.H. Zheng, P. Jul 2017. A. Parker, W. Teo, J. McCarroll, M. Bakthavathsalam, R.D. Tilley, N.A. Kavallaris. “Structural Domains of Lee, J.J. Gooding, “Immuno-Gold E. Du, “Self-assembled peptide betaIII-Tubulin Regulate Multiple Nanorods Composite for Food hydrogels as fully defined 3D cell th Stress Responses and Influence th Safety Monitoring”, 8 matrices”, 8 International Cell Growth and Survival in International Nanomedicine Nanomedicine Conference, Glucose-Depriced Non-Small Cell Conference, Sydney, Australia, 3-5 Sydney, Australia, 3-5 Jul 2017. Lung Cancer”. 2017 AACR Annual Jul 2017. Meeting. G. Duche, “Encapsulating self-

L. Zarei, M.H. Choudhury, R. assembled peptide hydrogels in W. Teo, T. Dwarte, T. Failes, G. Tavallaie, V.R. Gonçales, S. Ciampi, liposomes for drug delivery and Arndt, J. McCarroll, M. Kavallaris. th S.G. Parker, J.J. Gooding, aesthetic therapy”, 8 “High throughput kinase inhibitor “Fabrication of High-Density DNA International Nanomedicine screen reveals novel inhibitor Microelectrode Arrays Using Light Conference, Sydney, Australia, 3-5 combinations acting in synergy Activated Electrochemistry”, Jul 2017. with TUBB3/βIII-tubulin Pittcon 2017, Chicago, USA, 5-9 suppression in non-small cell lung Mar 2017. M. Lawler, “Peroxide Responsive cancer”. 2017 AACR Annual Bio-mimetic gels as sensors for Meeting. th R. Piya, J.J. Gooding, P.J. Reece, oxidative cellular stress”, 8

A.H. Soeriyadi, “Cell Based International Nanomedicine Biosensing on Micropatterned

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Conference, Sydney, Australia, 3-5 A. Rashleigh, “Fluorescently Conference, Sydney, Australia, 3-5 Jul 2017. Labelled Peptides That Bind to the Jul 2017. Complement 5A Receptor”, 8th F. Mansfeld, “An anti-GD2- International Nanomedicine C.K. Wong, “One polymer, multiple doxorubicin Conjugate for Conference, Sydney, Australia, 3-5 polymersome shapes and sizes - Treatment of Neuroblastoma”, 8th Jul 2017. but which has better cellular International Nanomedicine uptake properties and tumour Conference, Sydney, Australia, 3-5 S. Tan, “Using Fluorescent Probes penetration ability?”, 8th Jul 2017. to Elucidate Sweet Taste Receptor International Nanomedicine Function”, 8th International Conference, Sydney, Australia, 3-5 H. McEwen, “Designing Tunable Nanomedicine Conference, Jul 2017. Transfection Agents Using Self- Sydney, Australia, 3-5 Jul 2017. Assembling Short Peptides”, 8th J. Wojciechowski, “Chemically International Nanomedicine K. Tjandra, “Tumour-Targeting Programmed Supramolecular Conference, Sydney, Australia, 3-5 Peptide for Cancer Therapy”, 8th Hydrogels”, 8th International Jul 2017. International Nanomedicine Nanomedicine Conference, Sydney, Australia, 3-5 Jul 2017.

The 2017 International Nanomedicine Conference was held at the beautiful Coogee beach, an inspiring environment that inspires greater science! 41

Publications

Books/Book Anastasaki A; Bibal B; Boyer C; Chen Chapman R; Melodia D; Qu JB; G; De P; Guillaume S; Huang X; Stenzel MH, 2017, 'Controlled Chapters Kumarasamy E; Xu FJ; Zhao Y, 2017, poly(olefin)s: Via decarboxylation of 'Outstanding Reviewers for: Polymer poly(acrylic acid)', Polymer Kutty SK; Ka Kit Ho K; Kumar N, 2017, Chemistry in 2016', Polymer Chemistry, vol. 8, pp. 6636 – 6643 'Nitric Oxide Donors as Antimicrobial Chemistry, vol. 8, pp. 1998 Agents', in Nitric Oxide Donors: Novel Chen R; Cole N; Dutta D; Kumar N; Biomedical Applications and Aragonès AC; Darwish N; Ciampi S; Willcox MD P, 2017, 'Antimicrobial Perspectives, pp. 169 - 189 Sanz F; Gooding JJ; DIéz-Pérez I, 2017, activity of immobilized lactoferrin 'Single-molecule electrical contacts and lactoferricin', Journal of on silicon electrodes under ambient Biomedical Materials Research - Part conditions', Nature Communications, B Applied Biomaterials, vol. 105, pp. Journal Articles vol. 8 2612 – 2617

Bagheri A; Arandiyan H; Adnan NN M; Cheng X; McVey BF P; Robinson AB; Adnan NN M; Ahmad S; Kuchel RP; Boyer C; Lim M, 2017, 'Controlled Longatte G; O'Mara PB; Tan VT G; Boyer C, 2017, 'Exploring the Direct Growth of Polymer Shell on Thordarson P; Tilley RD; Gaus K; potential of linear polymer structures Upconversion Nanoparticle Surface Gooding JJ, 2017, 'Protease sensing for the synthesis of fluorescent gold via Visible Light Regulated using nontoxic silicon quantum dots', nanoclusters', Materials Chemistry Polymerization', Macromolecules, Journal of Biomedical Optics, vol. 22 Frontiers, vol. 1, pp. 80 - 90 vol. 50, pp. 7137 – 7147

Choudhury MH; Ciampi S; Lu X; Kashi Agustina S; Tokuda M; Minami H; Barker EC; Martin AD; Garvey CJ; Goh MB; Zhao C; Gooding JJ, 2017, Boyer C; Zetterlund PB, 2017, CY; Jones F; Mocerino M; Skelton 'Spatially confined electrochemical 'Synthesis of polymeric nano-objects BW; Ogden MI; Becker T, 2017, activity at a non-patterned of various morphologies based on 'Thermal annealing behaviour and gel semiconductor electrode', block copolymer self-assembly using to crystal transition of a low Electrochimica Acta, vol. 242, pp. 240 microporous membranes', Reaction molecular weight hydrogelator', Soft – 246 Chemistry & Engineering, vol. 2, pp. Matter, vol. 13, pp. 1006 – 1011 451-457 Chow E; Liana DD; Raguse B; Gooding

Beves JE; Harper JB; Thordarson P, JJ, 2017, 'A Potentiometric Sensor for Aldilla VR; Bhadbhade M; 2017, '23rdIUPAC Conference on pH Monitoring with an Integrated Bhattacharyya S; Kumar N; Rich AM; Physical Organic Chemistry (ICPOC- Electrochromic Readout on Paper', Marjo CE, 2017, 'Controlling the 23)', Pure and Applied Chemistry, vol. Australian Journal of Chemistry, vol. distance between hydrogen-bonded 89, pp. 677 70, pp. 979 – 984 chloro-: S -triazine tapes: Crystal engineering using N -alkyl chains and Biswas NN; Yu TT; Kimyon Ö; Chu EP F; Elso CM; Pollock AH; Alsayb the influence of temperature', Nizalapur S; Gardner CR; Manefield MA; Mackin L; Thomas HE; Kay TW H; CrystEngComm, vol. 19, pp. 4749 - M; Griffith R; Black DS; Kumar N, Silveira PA; Mansell AS; Gaus K; 4758 2017, 'Synthesis of antimicrobial Brodnicki TC, 2017, 'Disruption of

glucosamides as bacterial quorum Serinc1, which facilitates serine- Aldilla VR; Nizalapur S; Martin A; sensing mechanism inhibitors', derived lipid synthesis, fails to alter Marjo CE; Rich A; Yee E; Suwannakot Bioorganic & Medicinal Chemistry, macrophage function, lymphocyte P; Black DS; Thordarson P; Kumar N, vol. 25, pp. 1183 – 1194 proliferation or autoimmune disease 2017, 'Design, synthesis, and susceptibility', Molecular characterisation of glyoxylamide- Boyer CA; Miyake GM, 2017, Immunology, vol. 82, pp. 19 – 33 based short peptides as self- 'Polymers and Light', Macromolecular assembled gels', New Journal of Rapid Communications, vol. 38 Corrigan N; Almasri A; Taillades W; Xu Chemistry, vol. 41, pp. 13462 - 13471

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J; Boyer C, 2017, 'Controlling Dobrowolski JC; Somphol K; Santoso mediates neuroblastoma metastasis Molecular Weight Distributions M; Duong H; Gardner CR; Kumar N; in a tubulin-independent manner via through Photoinduced Flow Black DS C, 2017, 'Methanal extrusion RhoA/ROCK signaling and enhanced Polymerization', Macromolecules, in ipso-substitution reactions of transendothelial migration', vol. 50, pp. 8438 – 8448 hydroxymethylindoles', Australian Oncogene, vol. 36, pp. 501 – 511 Journal of Chemistry, vol. 70, pp. Daryl Ariawan A; Webb JE A; Howe 1188 – 1195 Fu C; Huang Z; Hawker CJ; Moad G; EN W; Gale PA; Thordarson P; Hunter Xu J; Boyer C, 2017, 'RAFT-mediated, L, 2017, 'Cyclic peptide unguisin A is Donor MT; Ewing SA; Zenaidee MA; visible light-initiated single unit an anion receptor with high affinity Donald WA; Prell JS, 2017, 'Extended monomer insertion and its for phosphate and pyrophosphate', Protein Ions Are Formed by the Chain application in the synthesis of Org. Biomol. Chem., vol. 15, pp. 2962 Ejection Model in Chemical sequence-defined polymers', Polymer – 2967 Supercharging Electrospray Chemistry, vol. 8, pp. 4637 – 4643 Ionization', Analytical Chemistry, vol. Del Prete S; Vullo D; Di Fonzo P; 89, pp. 5107 - 5114 Gao S; Mohammad M; Yang HC; Xu J; Osman SM; AlOthman Z; Donald WA; Liang K; Hou J; Chen V, 2017, 'Janus Supuran CT; Capasso C, 2017, Doonan C; Riccò R; Liang K; Bradshaw Reactors with Highly Efficient 'Sulfonamide inhibition profile of the D; Falcaro P, 2017, 'Metal-Organic Enzymatic CO2Nanocascade at Air- γ-carbonic anhydrase identified in the Frameworks at the Biointerface: Liquid Interface', ACS Applied genome of the pathogenic bacterium Synthetic Strategies and Materials and Interfaces, vol. 9, pp. Burkholderia pseudomallei the Applications', Accounts of Chemical 42806 – 42815 etiological agent responsible of Research, vol. 50, pp. 1423 – 1432 melioidosis', Bioorganic and Gooding JJ, 2017, 'How Do i Get My Medicinal Chemistry Letters, vol. 27, Du EY; Martin AD; Heu C; Thordarson Paper to Stand Out and Be Noticed?', pp. 490 – 495 P, 2017, 'The Use of Hydrogels as ACS Sensors, vol. 2, pp. 1546 Biomimetic Materials for 3D Cell Del Prete S; Vullo D; Osman SM; Cultures', Australian Journal of Gooding JJ; Bakker E; Kelley S; Long Y; AlOthman Z; Donald WA; Winum JY; Chemistry, vol. 70, pp. 1 – 8 Merkx M; Sailor M; Tao N, 2017, Supuran CT; Capasso C, 2017, 'Anion 'Should There Be Minimum inhibitors of the β-carbonic Dumlao M; Khairallah GN; Donald Information Reporting Standards for anhydrase from the pathogenic WA, 2017, 'Internal energy Sensors?', ACS Sensors, vol. 2, pp. bacterium responsible of tularemia, deposition in dielectric barrier 1377 – 1379 Francisella tularensis', Bioorganic and discharge ionization is significantly Medicinal Chemistry, vol. 25, pp. lower than in direct analysis in real- Gooding JJ; Bakker E; Kelley S; Long Y; 4800 – 4804 time mass spectrometry', Australian Merkx M; Sailor M; Tao N; Mazur A, Journal of Chemistry, vol. 70, pp. 2017, 'August 2017: Two Years of Ding Z; Ding M; Gao C; Boyer C; 1219 – 1226 Submissions', ACS Sensors, vol. 2, pp. Zhang W, 2017, 'In Situ Synthesis of 1068 – 1069 Coil-Coil Diblock Copolymer Dumlao MC; Xiao D; Zhang D; Nanotubes and Tubular Ag/Polymer Fletcher J; Donald WA, 2017, 'Effects Gooding JJ; Bakker E; Long Y; Tao N; Nanocomposites by RAFT Dispersion of Different Waveforms on the Kelley S; Merkx M; Sailor M; Mazur A, Polymerization in Poly(ethylene Performance of Active Capillary 2017, 'Welcome to the First glycol)', Macromolecules, vol. 50, pp. Dielectric Barrier Discharge Ionization Anniversary Issue of ACS Sensors', 7593 – 7602 Mass Spectrometry', Journal of the ACS Sensors, vol. 2, pp. 1 – 2 American Society for Mass Dobrowolski JC; Fraser BH; Spectrometry, vol. 28, pp. 575 - 578 Gooding JJ; Long YT; Tao N; Kelley S; Bhadbhade M; Black DS; Kumar N, Merkx M; Sailor M; Bakker E; Mazur 2017, 'Efficient Access to Chromeno Fife CM; Sagnella SM; Teo WS; A, 2017, 'Reflecting on How ACS [4,3- b ]quinolines Related to Po'Uha ST; Byrne FL; Yeap YY C; Ng Sensors Can Help Advance the Field Dependensin', Synlett, vol. 28, pp. DC H; Davis TP; McCarroll JA; of Sensing', ACS Sensors, vol. 2, pp. 1979 - 1983 Kavallaris M, 2017, 'Stathmin 455 – 456

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Goyette J; Gaus K, 2017, 'Mechanisms Chemical Communications, vol. 53, Kandemir H; Sengul IF; Kumar N; of protein nanoscale clustering', pp. 6488 – 6491 Black DS C, 2017, 'Synthesis of imine Current Opinion in Cell Biology, vol. and amine-linked macrocycles 44, pp. 86 – 92 Iranmanesh H; Arachchige KS A; containing tris-indoles', Australian Donald WA; Kyriacou N; Shen C; Price Journal of Chemistry, vol. 70, pp. Guo J; Richardson JJ; Besford QA; JR; Beves JE, 2017, 'Rage Against 1196 – 1201 Christofferson AJ; Dai Y; Ong CW; T Conformity: Ruthenium(II) ardy BL; Liang K; Choi GH; Cui J; Yoo Bisterpyridine Complexes Respond to Kashi MB; Silva SM; Yang Y; Gonçales PJ; Yarovsky I; Caruso F, 2017, Crystal Engineering Instructions with VR; Parker SG; Barfidokht A; Ciampi S; 'Influence of Ionic Strength on the Whelming Results', Australian Journal Gooding JJ, 2017, 'Light-activated Deposition of Metal-Phenolic of Chemistry, vol. 70, pp. 529 – 537 electrochemistry without surface- Networks', Langmuir, vol. 33, pp. bound redox species', Electrochimica 10616 – 10622 Jiang C; Moraes Silva S; Fan S; Wu Y; Acta, vol. 251, pp. 250 – 255 Alam MT; Liu G; Justin Gooding J, Guo K; Soeriyadi AH; Feng H; 2017, 'Aryldiazonium salt derived Kearnes M; Rickards L, 2017, 'Earthly Prévoteau A; Patil SA; Gooding JJ; mixed organic layers: From surface graves for environmental futures: Rabaey K, 2017, 'Heat-treated chemistry to their applications', Techno-burial practices', Futures, vol. stainless steel felt as scalable anode Journal of Electroanalytical 92, pp. 48 – 58 material for bioelectrochemical Chemistry, vol. 785, pp. 265 – 278 systems', Bioresource Technology, Kearnes M; van Dooren T, 2017, vol. 195 Jiang L; Gentile C; Lauto A; Cui C; 'Rethinking the Final Frontier: Cosmo- Song Y; Romeo T; Silva SM; Tang O; Logics and an Ethic of Interstellar Harrison R; Li L; Gu Z; Xu ZP, 2017, Sharma P; Figtree G; Gooding JJ; Flourishing', GeoHumanities, vol. 3, 'Controlling mesoporous silica- Mawad D, 2017, 'Versatile pp. 178 – 197 coating of layered double hydroxide Fabrication Approach of Conductive nanoparticles for drug control Hydrogels via Copolymerization with Krause-Heuer AM; Fraser-Spears R; release', Microporous and Vinyl Monomers', ACS Applied Dobrowolski JC; Ashford ME; Wyatt Mesoporous Materials, vol. 238, pp. Materials and Interfaces, vol. 9, pp. NA; Roberts MP; Gould GG; Cheah 97 – 104 44124 – 44133 WC; Ng CK L; Bhadbhade M; Zhang B; Greguric I; Wheate NJ; Kumar N; Koek Healey RD; Lebhar H; Hornung S; Jones CL; Marsden EA; Nevin A; W; Callaghan PD; Daws LC; Fraser BH, Thordarson P; Marquis CP, 2017, 'An Kariuki BM; Bhadbhade MM; Martin 2017, 'Evaluation of the improved process for the production AD; Easun TL, 2017, 'Investigating the antidepressant therapeutic potential of highly purified recombinant geometrical preferences of a flexible of isocyanine and pseudoisocyanine thaumatin tagged-variants', Food benzimidazolone-based linker in the analogues of the organic cation Chemistry, vol. 237, pp. 825 – 832 synthesis of coordination polymers', decynium-22', European Journal of Royal Society Open Science, vol. 4 Medicinal Chemistry, vol. 137, pp. Hinde E; Thammasiraphop K; Duong 476 – 487 HT T; Yeow J; Karagoz B; Boyer C; Jung K; Boyer C; Zetterlund PB, 2017, Gooding JJ; Gaus K, 2017, 'Pair 'RAFT iniferter polymerization in Kunz-Schughart LA; Dubrovska A; correlation microscopy reveals the miniemulsion using visible light', Peitzsch C; Ewe A; Aigner A; role of nanoparticle shape in Polymer Chemistry, vol. 8, pp. 3965 – Schellenburg S; Muders MH; Hampel intracellular transport and site of 3970 S; Cirillo G; Iemma F; Tietze R; Alexiou drug release', Nature C; Stephan H; Zarschler K; Vittorio O; Nanotechnology, vol. 12, pp. 81 – 89 Kabir KM M; Donald WA, 2017, Kavallaris M; Parak WJ; Mädler L; 'Microscale differential ion mobility Pokhrel S, 2017, 'Nanoparticles for Ho KK K; Ozcelik B; Willcox MD P; spectrometry for field deployable radiooncology: Mission, vision, Thissen H; Kumar N, 2017, 'Facile chemical analysis', TrAC - Trends in challenges', Biomaterials, vol. 120, solvent-free fabrication of nitric oxide Analytical Chemistry, vol. 97, pp. 399 pp. 155 – 184 (NO)-releasing coatings for – 427 prevention of biofilm formation', Kushwaha ND; Mondal S; Sharma R;

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Kumar N, 2017, 'Synthesis and and in vitro osteogenic properties polysaccharides', Chem. Commun., characterization of Imidazo [1,2- towards load-bearing applications', vol. 53, pp. 1249 – 1252 a]pyridines and Zolimidine', Asian Journal of Tissue Engineering and Journal of Chemistry, vol. 29, pp. Regenerative Medicine, vol. 11, pp. Long Y; Gooding JJ, 2017, 'Sensors in 1495 – 1498 1741 – 1753 China', ACS Sensors, vol. 2, pp. 1753 – 1754 Laos AJ; Dean JC; Toa ZS D; Wilk KE; Li N; Ding D; Pan X; Zhang Z; Zhu J; Scholes GD; Curmi PM G; Thordarson Boyer C; Zhu X, 2017, 'Temperature Lovelace MD; Powter EE; Coleman P, 2017, 'Cooperative Subunit programed photo-induced RAFT PR; Zhao Y; Parker A; Chang GH; Lay Refolding of a Light-Harvesting polymerization of stereo-block AJ; Hunter J; McGrath AP; Jormakka Protein through a Self-Chaperone copolymers of poly(vinyl acetate)', M; Bertolino P; McCaughan G; Mechanism.', Angew Chem Int Ed Polymer Chemistry, vol. 8, pp. 6024 – Kavallaris M; Vadas MA; Gamble JR, Engl, vol. 56, pp. 8384 – 8388 6027 2017, 'The RhoGAP protein ARHGAP18/SENEX localizes to Leeming MG; Donald WA; O'Hair RA Li YX; Gautam V; Brüstle A; Cockburn microtubules and regulates their J, 2017, 'Nontargeted Identification IA; Daria VR; Gillespie C; Gaus K; Alt stability in endothelial cells', of Reactive Metabolite Protein C; Lee WM, 2017, 'Flexible polygon- Molecular Biology of the Cell, vol. 28, Adducts', Analytical Chemistry, vol. mirror based laser scanning pp. 1066 – 1078 89, pp. 5748 – 5756 microscope platform for multiphoton in-vivo imaging', Journal of Lu X; Nicovich PR; Gaus K; Gooding JJ, Levrier C; Rockstroh A; Gabrielli B; Biophotonics, vol. 10, pp. 1526 – 2017, 'Towards single molecule Kavallaris M; Lehman M; Davis RA; 1537 biosensors using super-resolution Sadowski MC; Nelson CC, 2017, fluorescence microscopy', Biosensors 'Discovery of Thalicthuberine as a Liana AE; Marquis CP; Gunawan C; and Bioelectronics, vol. 93, pp. 1 - 8, Novel Antimitotic Agent from Nature Gooding JJ; Amal R, 2017, 'T4 that Disrupts Microtubule Dynamics bacteriophage conjugated magnetic Lu Z; Chen Y; Dunstan C; Roohani- and Induces Apoptosis in Prostate particles for E. coli capturing: Esfahani S; Zreiqat H, 2017, 'Priming Cancer Cells.', Cell Cycle Influence of bacteriophage loading, Adipose Stem Cells with Tumor temperature and tryptone', Colloids Necrosis Factor-Alpha Levrier C; Sadowski MC; Rockstroh A; and Surfaces B: Biointerfaces, vol. Preconditioning Potentiates Their Gabrielli B; Kavallaris M; Lehman M; 151, pp. 47 – 57 Exosome Efficacy for Bone Davis RA; Nelson CC, 2017, '6α- Regeneration', Tissue Engineering - Acetoxyanopterine: A novel structure Liana DD; Raguse B; Gooding JJ; Chow Part A, vol. 23, pp. 1212 – 1220 class of mitotic inhibitor disrupting E, 2017, 'A balance-in-a-box: An microtubule dynamics in prostate integrated paper-based weighing Ma Y; Pandzic E; Nicovich PR; cancer cells', Molecular Cancer balance for infant birth weight Yamamoto Y; Kwiatek J; Pageon SV; Therapeutics, vol. 16, pp. 3 – 15 determination', Analytical Methods, Benda A; Rossy J; Gaus K, 2017, 'An vol. 9, pp. 66 – 75 intermolecular FRET sensor detects Li B; Gu Z; Kurniawan N; Chen W; Xu the dynamics of T cell receptor ZP, 2017, 'Manganese-Based Layered Liang K; Richardson JJ; Doonan CJ; clustering', Nature Communications, Double Hydroxide Nanoparticles as a Mulet X; Ju Y; Cui J; Caruso F; Falcaro vol. 8 T1-MRI Contrast Agent with P, 2017, 'An Enzyme-Coated Metal– Ultrasensitive pH Response and High Organic Framework Shell for Ma Y; Poole K; Goyette J; Gaus K, Relaxivity', Advanced Materials, vol. Synthetically Adaptive Cell Survival', 2017, 'Introducing membrane charge 29 Angewandte Chemie - International and membrane potential to T cell Edition, vol. 56, pp. 8510 – 8515 signaling', Frontiers in Immunology, Li JJ; Roohani-Esfahani SI; Kim K; vol. 8 Kaplan DL; Zreiqat H, 2017, 'Silk Liang K; Wang R; Boutter M; Doherty coating on a bioactive ceramic CM; Mulet X; Richardson JJ, 2017, Ma Y; Yamamoto Y; Nicovich PR; scaffold for bone regeneration: 'Biomimetic mineralization of metal– Goyette J; Rossy J; Gooding JJ; Gaus effective enhancement of mechanical organic frameworks around K, 2017, 'A FRET sensor enables

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quantitative measurements of Germanium Nanocrystals', fluorescence microscopy', PLoS ONE, membrane charges in live cells', ChemPlusChem, vol. 82, pp. 60 – 73 vol. 12 Nature Biotechnology, vol. 35, pp. 363 – 370 Moir M; Chua SW; Reekie T; Martin Nizalapur S; Kimyon O; Yee E; AD; Ittner A; Ittner LM; Kassiou M, Bhadbhade MM; Manefield M; Martin AD; Easun TL; Argent SP; 2017, 'Ring-opened Willcox M; Black DS; Kumar N, 2017, Lewis W; Blake AJ; Schröder M, 2017, aminothienopyridazines as novel tau 'Synthesis and biological evaluation 'The effect of carboxylate position on aggregation inhibitors', of novel acyclic and cyclic glyoxamide the structure of a metal organic MedChemComm, vol. 8, pp. 1275 – based derivatives as bacterial framework derived from 1282 quorum sensing and biofilm cyclotriveratrylene', CrystEngComm, inhibitors', Organic and Biomolecular vol. 19, pp. 603 – 607 Mollazade M; Tabarin T; Nicovich PR; Chemistry, vol. 15, pp. 5743 – 5755 Soeriyadi A; Nieves DJ; Gooding JJ; Martin AD; Wojciechowski JP; Gaus K, 2017, 'Can single molecule Nizalapur S; Kimyon O; Yee E; Ho K; Robinson AB; Heu C; Garvey CJ; localization microscopy be used to Berry T; Manefield M; Cranfield CG; Ratcliffe J; Waddington LJ; Gardiner J; map closely spaced RGD Willcox M; Black DS C; Kumar N, Thordarson P, 2017, 'Controlling self- nanodomains?', PloS one, vol. 12, pp. 2017, 'Amphipathic guanidine- assembly of diphenylalanine peptides e0180871 embedded glyoxamide-based at high pH using heterocyclic capping peptidomimetics as novel groups', Scientific Reports, vol. 7 Nam E; Wong EH H; Tan S; Fu Q; antibacterial agents and biofilm Blencowe A; Qiao GG, 2017, disruptors', Organic and Biomolecular Mcewen H; Du EY; Mata JP; 'Antifogging Surface Facilitated by Chemistry, vol. 15, pp. 2033 – 2051 Thordarson P; Martin AD, 2017, Nanoscale Coatings with Controllable 'Tuning hydrogels through metal- Hydrophobicity and Cross-Linking Oliver S; Hook JM; Boyer C, 2017, based gelation triggers', Journal of Density', Macromolecular Materials 'Versatile oligomers and polymers Materials Chemistry B, vol. 5, pp. and Engineering, vol. 302 from flavonoids-a new approach to 9412 – 9417 synthesis', Polymer Chemistry, vol. 8, Ng G; Yeow J; Xu J; Boyer C, 2017, pp. 2317 – 2326 McGrath AJ; Cheong S; Henning AM; 'Application of oxygen tolerant PET- Gooding JJ; Tilley RD, 2017, 'Size and RAFT to polymerization-induced self- Oliver S; Jofri A; Thomas DS; Vittorio shape evolution of highly magnetic assembly', Polymer Chemistry, vol. 8, O; Kavallaris M; Boyer C, 2017, iron nanoparticles from successive pp. 2841 – 2851 'Tuneable catechin functionalisation growth reactions', Chemical of carbohydrate polymers', Communications, vol. 53, pp. 11548 – Nguyen TK; Lam SJ; Ho KK K; Kumar Carbohydrate Polymers, vol. 169, pp. 11551 N; Qiao GG; Egan S; Boyer C; Wong 480 – 494 EH H, 2017, 'Rational Design of McVey BF P; O'Mara PB; McGrath AJ; Single-Chain Polymeric Nanoparticles Ozcelik B; Chen R; Glattauer V; Kumar Faramus A; Yasarapudi VB; Gonçales That Kill Planktonic and Biofilm N; Willcox MP; Thissen H, 2017, VR; Tan VT G; Schmidt TW; Gooding Bacteria', ACS Infectious Diseases, 'Crosslinked Platform Coatings JJ; Tilley RD, 2017, 'Role of Surface vol. 3, pp. 237 – 248 Incorporating Bioactive Signals for Capping Molecule Polarity on the the Control of Biointerfacial Optical Properties of Solution Nicovich PR; Owen DM; Gaus K, 2017, Interactions', Macromolecular Synthesized Germanium 'Turning single-molecule localization Bioscience, vol. 17 Nanocrystals', Langmuir, vol. 33, pp. microscopy into a quantitative 8790 – 8798 bioanalytical tool', Nature Protocols, Ozcelik B; Ho KK K; Glattauer V; vol. 12, pp. 453 – 461 Willcox M; Kumar N; Thissen H, 2017, McVey BF P; Prabakar S; Gooding JJ; 'Poly(ethylene glycol)-based coatings Tilley RD, 2017, 'Solution Synthesis, Nicovich PR; Walsh J; Böcking T; Gaus combining low-biofouling and Surface Passivation, Optical K, 2017, 'NicoLase - An open-source quorum-sensing inhibiting properties Properties, Biomedical Applications, diode laser combiner, fiber launch, to reduce bacterial colonization', ACS and Cytotoxicity of Silicon and and sequencing controller for Biomaterials Science and

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Xu J; Fu C; Shanmugam S; Hawker CJ; phenoxodiol-β-cyclodextrin complex', Zhu H; Liu A; Li D; Zhang Y; Wang X; Moad G; Boyer C, 2017, 'Frontispiece: Carbohydrate Polymers, vol. 165, pp. Yang W; Gooding JJ; Liu J, 2017, Synthesis of Discrete Oligomers by 444 – 454 'Wafer-scale fabrication of a Sequential PET-RAFT Single-Unit Cu/graphene double-nanocap array Monomer Insertion', Angewandte Yeo D; Phillips P; Baldwin GS; He H; for surface-enhanced Raman Chemie International Edition, vol. 56, Nikfarjam M, 2017, 'Inhibition of scattering substrates', Chemical pp. 8376 – 8383 group 1 p21-activated kinases Communications, vol. 53, pp. 3273 – suppresses pancreatic stellate cell 3276 Xu S; Ng G; Xu J; Kuchel RP; Yeow J; activation and increases survival of Boyer C, 2017, '2-(Methylthio)ethyl mice with pancreatic cancer', Zuo H; Chen W; Li B; Xu K; Cooper H; Methacrylate: A Versatile Monomer International Journal of Cancer, vol. Gu Z; Xu ZP, 2017, 'MnAl Layered for Stimuli Responsiveness and 140, pp. 2101 – 2111 Double Hydroxide Nanoparticles as a Polymerization-Induced Self- Dual-Functional Platform for Assembly in the Presence of Air', ACS Yeow J; Boyer C, 2017, Magnetic Resonance Imaging and Macro Letters, vol. 6, pp. 1237 – 1244 'Photoinitiated Polymerization- siRNA Delivery', Chemistry - A Induced Self-Assembly (Photo-PISA): European Journal, vol. 23, pp. 14299 - Yang B; Gu Z; Chen Y, 2017, New Insights and Opportunities', 14306 'Nanomedicine-augmented cancer- Advanced Science, vol. 4 localized treatment by 3D theranostic implants', Journal of Biomedical Yeow J; Chapman R; Xu J; Boyer C, Nanotechnology, vol. 13, pp. 871 – 2017, 'Oxygen tolerant 890 photopolymerization for ultralow Creative Works (non- volumes', Polymer Chemistry, vol. 8, Yang Y; Ciampi S; Gooding JJ, 2017, pp. 5012 – 5022 textual) 'Coupled Thermodynamic and Kinetic Changes in the Electrochemistry of Yu TT; Nizalapur S; Ho KK K; Yee E; Mcghee J; Bailey B; Faux S; Ferrocenyl Monolayers Induced by Berry T; Cranfield CG; Willcox M; Thompson-butel A; Bou-Haidar P; Light', Langmuir, vol. 33, pp. 2497 – Black DS; Kumar N, 2017, 'Design, Shiner C, 2017, Stroke: Occlusion and 2503 Synthesis and Biological Evaluation of Flow, Blood Attract or Repel, Science N-Sulfonylphenyl glyoxamide-Based Gallery Melbourne, The University of Yee EM H; Brandl MB; Black DS C; Antimicrobial Peptide Mimics as Melbourne, 02 August - 23 Vittorio O; Kumar N, 2017, 'Synthesis Novel Antimicrobial Agents', September 2017, medium: 3D of isoflavene-thiosemicarbazone Chemistryselect, vol. 2, pp. 3452 – Interactive Virtual Reality Experience hybrids and evaluation of their anti- 3461 - Oculus Rift Head Mounted Display tumor activity', Bioorganic and Medicinal Chemistry Letters, vol. 27, Zenaidee MA; Leeming MG; Zhang F; pp. 2454 – 2458 Funston TT; Donald WA, 2017, 'Highly Conference Papers Charged Protein Ions: The Strongest

Yee EM H; Brandl MB; Pasquier E; Organic Acids to Date', Angewandte He X; Gaus K; Lee WM, 2017, 'Label- Cirillo G; Kimpton K; Kavallaris M; Chemie - International Edition, vol. free dynamic volumetric imaging of Kumar N; Vittorio O, 2017, 'Dextran- 56, pp. 8522 – 8526 deforming giant unilamellar vesicles Catechin inhibits angiogenesis by under micro-flows', in Optics disrupting copper homeostasis in Zhao Y; Xu Y; Zeng J; Kong B; Geng X; InfoBase Conference Papers endothelial cells', Scientific Reports, Li D; Gao X; Liang K; Xu L; Lian J; vol. 7 Huang S; Qiu J; Huang Y; Li H, 2017, Baek J; Lou J; Coelho S; Lim YJ; 'Low-crystalline mesoporous Seidlitz S; Nicovich PR; Wunder C; Yee EM H; Hook JM; Bhadbhade MM; CoFe2O4/C composite with oxygen Johannes L; Gaus K, 2017, 'Imaging Vittorio O; Kuchel RP; Brandl MB; vacancies for high energy density galectin-3 dependent endocytosis Tilley RD; Black DS C; Kumar N, 2017, asymmetric supercapacitors', RSC with lattice light-sheet microscopy', 'Preparation, characterization and in Advances, vol. 7, pp. 55513 – 55522 in Progress in Biomedical Optics and vitro biological evaluation of (1:2)

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Imaging - Proceedings of SPIE Y; Ozkan J; Cole N; Zhu H; Kumar NA contact lenses', presented at Asia R E S H, 2017, 'Human clinical testing Association for Research in Vision Cheng X; McVey BF P; Robinson AB; of antimicrobial contact lenses.', and Ophthalmology, Brisbane, Longatte G; O'Mara PB; Tan VT G; presented at International Australia, 05 - 08 February 2017 Thordarson P; Tilley RD; Gaus K; Conference on Antimicrobial Gooding JJ, 2017, 'Colloidal silicon Research, Madrid, Spain, 01 - 03 Cheng X; McVey BF P; Robinson AB; quantum dots: From preparation to October 2017 Longatte G; O'Mara PB; Tan VT G; the modification of self-assembled Thordarson P; Tilley RD; Gaus K; monolayers for bioimaging and Dutta D; Kumar N; Kamphuis B; Gooding JJ, 2017, 'Colloidal silicon sensing applications', in Progress in willcox M, 2017, 'Silicone hydrogel quantum dots: From preparation to Biomedical Optics and Imaging - antimicrobial contact lenses', the modification of self-assembled Proceedings of SPIE presented at International Society of monolayers for bioimaging and Contact Lens Research, Stevenson, sensing applications', in Progress in Chen R; Willcox M; Dutta D; Cole N; WA, USA, 14 - 18 August 2017 Biomedical Optics and Imaging - Kumar N, 2017, 'Inhibition of in vivo Proceedings of SPIE microbial colonisation of biomaterials Dutta D; Mawad D; Kumar N; Willcox based on cationic peptide melimine.', M, 2017, 'Synergistic activity of Dutta D; Mawad D; Kumar N; Willcox in Inhibition of in vivo microbial biomedical surface immobilised and M, 2017, 'Synergistic activity of colonisation of biomaterials based on free antimicrobials.', presented at biomedical surface immobilised and cationic peptide melimine., The Australian Society for free antimicrobials.', presented at presented at International biomaterials and Tissue Engineering, The Australian Society for Conference on Antimicrobial Canberra, Australia, 18 - 20 April biomaterials and Tissue Engineering, Research, Madrid, Spain, 01 - 03 2017 Canberra, Australia, 18 - 20 April October 2017 2017 Dutta D; Kumar N; Willcox M, 2017, Willcox M; Dutta D; Chen R; Ho KI T T 'Silicone hydrogel antimicrobial

Nguyen TK; Lam SJ; Ho KK K; Kumar N; Qiao GG; Egan S; Boyer C; Wong EH Xu J; Fu C; Shanmugam S; Hawker CJ; Moad G; Boyer C, 2017, Lovelace MD, Powter EE, Coleman PR, Zhao Y, Parker A, Chang H, 2017, 'Rational Design of Single-Chain Polymeric Nanoparticles That Kill 'Frontispiece: Synthesis of Discrete Oligomers by Sequential PET- GH, Lay AJ, Hunter J, McGrath AP, Jormakka M, Bertolino P, Planktonic and Biofilm Bacteria', ACS Infectious Diseases, vol. 3, pp. 237 – RAFT Single-Unit Monomer Insertion', Angewandte Chemie McCaughan G, Kavallaris M, Vada MA, Gamble JR (2017), The 248 (Cover image) International Edition, vol. 56, pp. 8376 – 8383 (IF= 11.5) RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells Mol. Biol. Cell 28:8 1066-1078

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Financial Report

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