University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School 2011 Crystal Engineering of Multiple Component Crystal Forms of Active Pharmaceutical Ingredients David Rudy Weyna University of South Florida,
[email protected] Follow this and additional works at: https://scholarcommons.usf.edu/etd Part of the American Studies Commons, and the Other Education Commons Scholar Commons Citation Weyna, David Rudy, "Crystal Engineering of Multiple Component Crystal Forms of Active Pharmaceutical Ingredients" (2011). Graduate Theses and Dissertations. https://scholarcommons.usf.edu/etd/3406 This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact
[email protected]. Crystal Engineering of Multiple Component Crystal Forms of Active Pharmaceutical Ingredients by David R. Weyna A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Chemistry College of Arts and Sciences University of South Florida Major Professor: Michael J. Zaworotko, Ph.D. Roman Manetsch, Ph.D. John Koomen, Ph.D. Peter Karpinski, Ph.D. Mazen Hanna, Ph. D. Date of Approval: March 23, 2011 Keywords: Pharmaceutical Cocrystal, Supramolecular Chemistry, Zwitterion, Physicochemical Properties, and Pharmacokinetics Copyright © 2011, David R. Weyna Dedication For Bryana and Izabelle Acknowledgements I would like to thank Dr. Michael Zaworotko first and foremost for the chance to work in his group and his advice as a mentor throughout the doctoral program. I would like to thank the various Zaworotko group members for their helpful input through discussions and hands on training, and the members of my committee, Dr.