Contents

1 About the ACN

3 Directors’ Report

5 At a Glance

7 Research

8 2016 New Grant Funding

10 2016 New Research Projects

14 High Impact Papers

15 Engagement

16 Media

19 Events

20 Presentation

25 Collaborating Organisations

26 Awards, Prizes and Achievements

28 Governance, Our People & Visitors

29 Steering Committee

30 Organisational Chart

31 ACN Staff and Students

33 Visitors to the ACN

34 Publications

42 Cover Gallery

43 Financial Report

About the ACN

The ACN was established in mid-2011 as a national innovator in NanoMedicine, bringing together a diverse team of leading researchers in Medicine, Science and Engineering to deliver the next generation of health innovations, and is dedicated to providing new solutions for therapeutics and diagnostics enabled by nanotechnology.

The key science that underpins all the activities of the Centre is to fully understand and exploit the unique properties of nanomaterials for various applications (eg. Contrast agents for cell imaging and therapeutics for treating cancer). The Centre’s strategic vision is to create teams focused on particular diseases using Team ACN’s skills in drug delivery, diagnostics and imaging.

To succeed in this, it requires an integrated team of researchers coming from diverse backgrounds and we have assembled a remarkable team of highly distinguished scientists and engineers covering nanotechnology, polymer science, cancer biology, chemical engineering, microfluidic, chemistry, sensors and imaging, social science and experimental arts (3D imaging) from five UNSW faculties: Medicine, Science, Engineering, Arts & Social Sciences, and Arts and Design.

Dr Friederike Mansfeld, Senior Research Officer at Children's Cancer Institute

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Dr. Robert Utama setting up a RAFT polymerization reaction with PhD student Kelly Zong.

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Directors’ Report

Scientia Professor Professor Maria Kavallaris Professor Cyrille Boyer Justin Gooding

2016 marks the 3rd year of cross-disciplinary output across the major conferences and meetings implementation of the Centre’s Centre. In 2016, we have over 113 including the 7th International 2nd strategic plan of 5 years. We publications, 7 book chapters and 3 Nanomedicine Conference, held in have grown from the initial 40+ patents with a growing number of Coogee on 27-29 June, where ACN research team from the inception papers published from the Centre’s researchers contributed many of the Centre to today’s 120 strong collaborative research programs. lectures. The Biomedical Futures team spread across five UNSW We published 14 papers with workshop organised by Associate faculties, encompassing a huge impact factors above 10 in the Professor Matthew Kearnes in amount of activities. We hope this following prestigious journals: December 2016 brought together report gives a flavour of the Chemical Reviews, Chemical primary care networks, clinicians, achievements we have made in Society Reviews, Nano Letters, care professionals, ACN 2016. Nature Nanotechnology, Science, researchers, and healthcare Advanced Drug Delivery Reviews, administrators, to co-design major The past twelve months has seen Journal of the American Chemical public events in NSW, Victoria and outstanding scientific output, Society, Angewandte Chemie and Queensland on precision medicine. significant capacity building, the Advanced Materials. growth of National and • Numerous high profile International collaboration, • Significant amount of awards and fellowships. ARC leadership in organising and grant funding for collaborative Laureate Fellow and Scientia leading significant research research. Total new grant funding Professor Justin Gooding was conference and workshops, for ACN members reached a record elected Fellow of the Australian numerous prizes, awards and high of $17M. Including NHMRC Academy of Science. Professor fellowships, together with a strong Program Grant APP1091261 2016- Maria Kavallaris was awarded the media profile to communicate our 2020 $7M+ awarded to Professors NHMRC Principal Research purpose and successes. Kavallaris, Gooding, et al. The aim Fellowship and inducted as a of the Program Grants scheme is to Fellow of the Australian Academy Some areas we would like to provide support for teams of high of Health and Medical Sciences highlight are: calibre researchers to pursue (AAHMS). Cyrille Boyer won the broad based, multi-disciplinary and ACS Biomacromolecules/ • Research productivity was collaborative research addressing Macromolecules Award and was extremely impressive in 2016 complex problems. awarded the LeFevre Memorial including high-impact papers in Prize by the Australian Academy of chemistry, polymer science and • Leadership and Science. It was also great medicine, with increasing focus on participation in the organisation of recognition that Cyrille was 3 promoted to Professor. Dr Jason • Our Centre researchers Centre going from strength to Xu from Professor Cyrille Boyer’s gave over 40 plenary, keynote or strength. We commend to you this group was awarded the prestigious invited talks at major international report on our activities and events ARC Future Fellowship. It is not conferences. Many of these talks and we look forward to reporting possible to list all the awards and were fully or partially financially on more exciting research and prizes in this highlight section, supported. successes in the future. more awards are listed in the main body of the report, clearly • It is tremendous that we indicating significant outside are actively hosting a large number recognition of the quality of of domestic and overseas visits to research being performed by ACN set up collaboration. Eminent researchers. visitors to the Centre include Professor George Whitesides from Justin Gooding • ACN researchers have Harvard University and Professor Centre Co-Director demonstrated significant Vince Rotello from University of interactions with the media; at the Massachusetts Amherst. forefront has been Professor Justin Gooding and team with numerous • ACN is attracting increasing numbers of young interviews and press releases talents to our research team. In relating to “A Paper Based Sensor Maria Kavallaris 2016 alone, 9 fresh talents joined for Monitor Sun Exposure”. There Centre Co-Director the team including Associate was also great media coverage of Phoebe Phillips, Joshua McCarroll, Professor John McGhee, whose Cyrille Boyer, Maria Kavallaris’ research explores arts-led modes journal paper “New cancer of visualising complex scientific and biomedical data using the 3D nanomedicine reduces pancreatic tumour growth”. Media reached CGI techniques. over 3 million people in Australia Cyrille Boyer In Summary, 2016 has seen our alone. Centre Co-Director

Dr Parisa Sowti Khiabani wearing a UV-sensitive skin patch developed by the Gooding Group

4 At a Glance

Our People

18 Members incl 7 Self-Funded 4 Associate 10 Self-Funded Research Members Fellows Fellows

8 Administration 73 Honours and 15 PostDocs and Technical PhD Students Staff

Research Output

Over $17M new funding to 113 Journal Publications, 7 14 journal publications with fund 30+ projects book chaptors and 3 patents impact factors >10 commencing in 2016

47 collaborating Over 40 Plenary, Keynote and organisations, including 3 17 interdisciplinary research Invited talks at major from China, 5 from USA, 12 projects international conferences, from Europe and 27 from many with financial support Australia & New Zealand

Numerous awards, prizes and 36 visitors (including 22 15 memberships on Editorial honours, including Eureka international) visited ACN for Boards Prize finalist and 2 collaboration Fellowships

Approx. 40 seminars, oral ACN hosted 7th International Over 80 media articles presentations and poster NanoMedicine Conference (including TV & Radio) both presentations at universities, where many ACN researchers in Australia and overseas symposiums and meetings contributed lectures

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Professor Cyrille Boyer and his PhD student Sivaprakash Shanmugam grinding spinach leaves to extract chlorophyll (from plants) to make photosensitive functional polymers.

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Research

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2016 New Grant Funding

Total new funding for ACN members’ research has reached a record level of over $17M in 2016. Below is a list of ACN funding highlights.

NHMRC Program Grant, APP1091261, ARC LIEF Projects, LE160100033, ARC Discovery Projects, Kavallaris, Gooding, et al. Precision Cyrille Boyer, et al. Equipment for DP160102681, William Donald. nanomedicine-based diagnostics and Advanced Surface Analysis. (2016). Rapid, ultra-sensitive protein therapeutics for refractory $500,000 structure elucidation by mass malignancies. (2016-2020). spectrometry. (2016-2018). $299,700 $7,088,520 NHMRC Equipment Grant (APP9000322): Live cell TIRF ARC Linkage Projects, LP160100573, Cancer Council Program Grant, PG16- microscope for HILO applications. Pall Thordarson, et al. Scaling 01, Kavallaris et al. Improving Gaus K, Kavallaris M, Phillips P, et al. manufacture of three-dimensional outcomes for children with leukaemia (2016). $390,000 microstructures for the medical through molecular targeted devices industry. (2016-2019). therapies. (2016-2020). $2,249,946 Cancer Council NSW project grant, $228,186 Phoebe Phillips, Joshua McCarroll, NHMRC Project Grant, APP1100202, Cyrille Boyer, et al. Reprogramming Cancer Institute NSW Career Elizabeth Hinde, et al. Regulation of the tumour microenvironment by Development Fellowship, Joshua ERK driven cell proliferation by the therapeutically targeting heat shock McCarroll. Nanomedicine-based treatment for lung cancer.(2016-). actin cytoskeleton. (2016-2019). proteins in pancreatic cancer.(2016-). $150,000 $920,972 $360,000 Cancer Council Program Grant , RG NSW Smart Sensing Network, Justin Cancer Institute NSW Equipment 16-08, Phoebel Phillips, et al. Gooding, William Donald. Public Grant: ‘High throughput five laser Reprogramming the tumour sector grant. (2016-). $900,000 flow cytometer’. Phillips P, et al. microenvironment by therapeutically (2016). $339,500 targeting heat shock proteins in ARC LIEF Projects, LE160100168, pancreatic cancer. $120,000 Justin Gooding, Cyrille Boyer, Pall ARC Linkage Projects, LP160100979, Thordarson, et al. Facility for Katharina Gaus. Modulating T cell The Kids Cancer Project, Maria Characterisation of BioNanomaterials responses with novel Lck activating Kavallaris. Stathmin regulation of (2016-). $650,000 compounds. (2016-2019). $335,000 microRNA expression in neuroblastoma cells. (2016-2017). NHMRC-ARC Dementia Research ARC Linkage Projects, LP160100575, $115,173 Development Fellowship, Adam Pall Thordarson, Richard Tilley, et al. Martin. Self-assembled hydrogels as a Precision luminescent solar UNSW MREII, Cyrille Boyer, et al. model for neurodegeneration (2016- concentrators from robust quantum Thermal and near ir spectrometers 2019). $594,644 dot arrays. (2016-2019). $330,378 for material analysis and surface characterisation. (2016-). $105,000 NHMRC Project Grant, APP1104461, NHMRC Equipment Grant – awarded Elizabeth Hinde, et al. The role of as part of the UNSW Major Research Ferronova Pty Ltd; Justin Gooding, nuclear architecture in the DNA Equipment and Infrastructure Richard Tilley. Industry grant. (2016- Damage Response. (2016-2018). Initiative Scheme (MREII): ‘3D Printed 2018). $102,500 $561,966 Scape Microscope’. Phillips P, et al. (2016). $300,000

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Ross Foundation Grant, Joshua Reprogramming the tumour micro- (2016). $19,000 McCarroll. Nanomedicine-based environment by therapeutically treatment to inhibit medulloblastoma targeting heat shock proteins in CCIA SPOT Award, Orazio Vittorio. Targeting copper homeostasis in growth.(2016). $100,000 pancreatic cancer. (2016-). $50,000 neuroblastoma. (2016). $12,000

Innovation Grant, Avner Pancreatic Ettason Pty Ltd; Pall Thordarson. AINSE Award, Orazio Vittorio. Cancer Foundation: ‘Elucidating the Industry grant. (2016-). $50,000 [64Cu]CuCl2 PET imaging to mechanism by which mutY-homolog investigate the effect of Dextran- UNSW Goldstar Research Grant: knockdown kills pancreatic cancer Catechin on copper metabolism in ‘Reprogramming the tumour cells. Phillips P, et al. (2016). neuroblastoma. (2016). $9,000 $100,000 microenvironment by therapeutically targeting heat shock proteins in Clockwerk Pty Ltd; Pall Thordarson. Steadfast Foundation Grant, Joshua pancreatic cancer’. Phillips P, Industry grant. (2016). $7,500 McCarroll. Nanoparticles carrying McCarroll J, et al. (2016). $40,000 RNA-based therapies to treat RR Medsciences Pty Ltd; Pall medulloblastoma. (2016-). $50,000 Australia-India Council (AIC) Board Thordarson. Industry grant. (2016). grant, Cyrille Boyer, Edgar Wong. $5,000 NHMRC Gold Star, Phoebe Phillips, Disinfecting Indian Waters with Novel Cyrille Boyer, Joshua McCarroll, et al. Antimicrobial Polymer Membranes.

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2016 New Research Projects

Nanomedicine-Based Treatment for pancreatic cancer growth and demonstrated the efficacy of this Lung Cancer improve the survival and quality of treatment. life for patients. Dr Joshua McCarroll, Prof Maria We have found evidence that the Kavallaris, Prof Tom Davis, A/Prof mechanism of action of this drug is Phoebe Phillips linked to intracellular copper (Cu) Development of Nanomedicines for trafficking and distribution. Our aim This new project will use the Treatment of Medulloblastoma 64 was therefore to employ [ Cu]CuCl2 to nanoparticles to package and deliver Dr Joshua McCarroll, Prof Maria monitor Cu distribution in-vivo in RNA-based drugs to silence the Kavallaris, Prof Tom Davis, Ms Helen neuroblastoma xenograft mouse expression of key genes in lung Forgham models, both with and without cancer cells which regulate tumour treatment. growth, metastases and Medulloblastoma is the most chemotherapy drug resistance. This common form of childhood brain A pilot study will be carried out in project involves collaboration with cancer. Despite an improvement in 5 normal healthy female BALB/c‐Fox1nu/ chemists at the Australian Centre for year survival patients often suffer Ausb mice (n=4, 6-8 weeks of age) to 64 NanoMedicine, UNSW and Monash from long-term off-target toxicity understand the clearance of [ Cu] over University as well as cancer biologists from the treatments which has a 2 days. For these pilots, 7-10MBq of 64 at the Children’s Cancer Institute and negative impact on their quality of [ Cu]CuCl2 in 100 µL will be injected via UNSW Australia. This study has the life. This multidisciplinary project lateral tail vein and imaged at time potential to produce a new class of involves chemists from the Australian points 0-2 h, 5 h, 24 h and 48 h (Inveon nanomedicines which inhibit lung Centre for NanoMedicine and PET/CT scanner). The human cancer growth and improve patient Monash university as well as cancer neuroblastoma BE(2)-C xenograft survival. biologists from the Children’s Cancer mouse model used for the study will be Institute to develop novel obtained by injecting 2X106 human

nanoparticles as delivery vehicles for neuroblastoma cells subcutaneously The Use of Nanoparticles for the therapeutic drugs to treat into female BALB/ c‐Fox1nu/Ausb mice Treatment of Pancreatic Cancer medulloblastoma. (6-8 weeks of age).

A/Prof Phoebe Phillips, Dr Joshua When the tumours size reach to 0.3 to McCarroll, Prof Maria Kavallaris, Prof 0.5 cm, typically after 12 days, the mice 64 Tom Davis, Prof Cyrille Boyer [ Cu]CuCl2 PET Imaging Revealed will be divided in to two groups: 1) that a Natural Derived Compound saline treated 2) dextran-catechin Pancreatic cancer is the 4th leading Dextran-Catechin Mediates Its treated; PET/CT scans were performed cause of cancer death in the world. It Anticancer Activity by on both groups. is predicted to be number 2 by 2030. Downregulating Copper Metabolism This project will use star in Neuroblastoma On the day of imaging, either saline nanoparticles developed by our team (100 µL) or dextran-catechin (300 µg in to deliver siRNA to pancreatic cancer A. Parmar , O. Vittorio, A. Charil, M. 100 µL of saline) will be injected in the cells to silence the expression of Brandl, K. Kimpton, G. Cirillo, M. mice 1 h prior to PET scan, and then genes which promote aggressive Kavallaris, G. Pascali anaesthesia will be performed using 2% 64 tumour growth. To examine the isoflurane. 7-10MBq of [ Cu]CuCl2 will Neuroblastoma is a very aggressive therapeutic potential of our novel be injected via lateral tail vein, cancer with high mortality rate in nanomedicines we will use mouse followed by PET/CT imaging at 0-2 h, 5 children. Our group studies the models which closely mimic the h, 24 h and 48 h post radiotracer effects of a novel treatment based on clinical setting. This project has great injection. a Dextran-Catechin conjugate on potential to generate a new class of animal models of neuroblastoma; After the imaging session, mice will be therapeutic drugs which inhibit survival and behavioural results have sacrificed and tissues collected for in

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vitro analysis. This opens the way to a Furthermore, the rise of antibiotic the spatiotemporal resolution currently deeper understanding of the resistance means there is an used to study chromatin biology. molecular basis of dextran-catechin increased urgency in developing novel treatment and its potential and effective materials to combat this applicability to other type of cancers global issue. By using advanced Precision Nanomedicine-Based depending on copper. polymer engineering, this project will Diagnostics and Therapeutics for provide effective nanomaterials that Refractory Malignancies can safeguard our health from 'bad Stathmin Regulation of Microrna bugs'. Prof Maria Kavallaris, Prof Justin Expression in Neuroblastoma Cells Gooding, Prof Richard Lock, Prof Tom Davis Maria Kavallaris, et al. Regulation of ERK Driven Cell The vast majority of cancer patients die Proliferation by the Actin Neuroblastoma, the most common of their disease due to the emergence Cytoskeleton solid tumour of young children, of drug resistant cancer cells or frequently presents with aggressive Dr Elizabeth Hinde, Prof Peter metastatic disease that is diagnosed at metastatic disease and for these Gunning, et al. late stages. Our program aims to children the 5-year survival rates are develop new types of therapy to dismal. The cells in your body respond to specifically target aggressive cancers. external signals and control their To detect cancer early and evaluate the Recently, research by the Kavallaris’ proliferation by transmitting signals effectiveness of cancer therapy, we will group and funded by The Kids’ Cancer from one part of the cell to another. develop sensitive diagnostic tools and Project has shown that a protein This has usually been thought to devices. This research has application called stathmin mediates involve the movement of signals to both childhood and adult cancers. neuroblastoma metastasis. Thanks to through a liquid medium without the continuation of funding by TKCP, the involvement of any machinery to project will focus on understanding control the movement. The project Self-Assembled Hydrogels as a Model the role that specific DNA sequences aims to test the role of the for Neurodegeneration play in regulating metastasis and architecture of the cells in physically potentially develop new targeted moving a growth signal from one Dr Adam Martin NHMRC-ARC therapies. place to another. We think that the Dementia Research Development architecture involved plays a key role Fellowship in cancer. Alzheimer’s disease (AD) is a Disinfecting Indian Waters with neurodegenerative disease which Novel Antimicrobial Polymer currently affects over 340,000 Membranes The Role of Nuclear Architecture in Australians. Often, symptoms of AD are the DNA Damage Response Cyrille Boyer, Edgar Wong not apparent until the disease is well Dr Elizabeth Hinde, et al. advanced, limiting chances of Cyrille Boyer & Edgar Wong will be successful treatment. In this project, collaborating with IITD materials The goal of the proposed research is hydrogels made from biocompatible scientist, Leena Nebhani, to develop to understand how dynamic changes peptides will be used to grow neural new and effective water purification to the chromatin genome packaging cell culture models to study the membranes that can kill multidrug- network, interact with the DNA development of the disease in its early resistant bacteria found in Indian damage response and gene stages. This will help to develop new waters. Clean and safe water supply expression machinery, to repair diagnostic tools for the early detection is essential for preventing the spread damaged DNA and the impact this has of AD. of infectious diseases caused by on cancer biology. To do so we are bacteria. In India, clean water supply combining cutting edge molecular remains inadequate and this has led biology techniques with innovative Scaling Manufacture of Three- to bacteria-causing diseases such as novel microscopy methods developed Dimensional Microstructures for the bloody diarrhoea or dysentery. by our research team, that far exceed

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Medical Devices Industry luminescent solar concentrator spectrometry. This would enable novel technology. sites of interactions between molecules ARC Linkage Projects and protein targets to be discovered Pall Thordarson, et al. rapidly with high sensitivity. In turn, this would allow the efficient design of This project aims to transform Modulating T Cell Responses with next-generation classes of bioactive microscale three-dimensional Novel Lck Activating Compounds molecules. prototyping into a cheap high volume ARC Linkage Projects manufacturing process through a Katharina Gaus, et al. novel soft embossing process.

Although three-dimensional printing Equipment for Advanced Surface This project aims to research T cell has been hailed as a disruptive Analysis receptor (TCR) signal initiation and technology, because it can print network plasticity and identify uses ARC LIEF Projects complex shapes directly from for drugs that affect the kinase Lck. Cyrille Boyer, et al. drawings, it is too slow at microscale The TCR signalling network has for high volume manufacture. This considerable plasticity so that This project aims to establish research will develop microdevices modulation of one molecule (here the equipment for advanced surface for painless collection of blood, its drug target is Lck) can have non-linear analysis to provide Australian analysis, and drug delivery. Cost- effects on T cell function. This project researchers with cutting-edge effective manufacture of these intends to use novel drugs to capabilities in surface science. Vital microdevices is expected to tap into understand how the T cell network chemical and physical reactions often the large medical devices industry, can be exploited to control both the occur at surfaces. Understanding these leading to establishing new magnitude and quality of the T cell reactions requires analysis of the businesses in the point-of-care and responses. This research is expected composition and electronic structure of drug delivery markets. to aid the design of immune- the surface and near-surface regions. Neutral impact collision ion scattering modulating drugs. spectroscopy and inverse Precision Luminescent Solar photoemission spectroscopy measure Concentrators from Robust Quantum concentration depth profiles and Rapid, Ultra-Sensitive Protein Dot Arrays electronic structure. The depth Structure Elucidation by Mass resolution of the profiles is in the order Spectrometry ARC Linkage Projects of the distance between two Pall Thordarson, Richard Tilley, et al. ARC Discovery Projects neighbouring atoms in a solid or liquid

William Donald and is the best currently achievable. This project aims to make The equipment providing these luminescent solar concentrators that This project seeks to develop a capabilities is expected to support can harness solar energy from method for rapidly discovering classes research with applications in surfaces not suited for conventional of molecules that bind to unique sites photovoltaics, catalysis, colloid surfaces solar cells, such as car windows. It will on proteins. The development of new and interfaces, coatings and design, synthesise and conduct pharmaceuticals is frequently delayed nanocomposites. detailed energy transfer studies of by the time and resources required to robust inorganic quantum dot arrays identify the sites that new chemical with fit-for-purpose precise spectral entities bind to protein targets. A Facility for Characterisation of properties. Synthetic light-harvesting recent discovery has resulted in the BioNanomaterials dye arrays have often been proposed ability to completely characterise to solve bottleneck challenges in the large protein sequences directly from Justin Gooding, Cyrille Boyer, Pall solar energy sector but there are single mass spectra. This project aims Thordarson, et al. issues with stability, processing and to leverage this breakthrough by their photophysical output matching The facility for characterisation of developing a rapid new approach for market needs. This project’s dyes are bionanomaterials aims to provide revealing ligand-protein binding sites expected to create market researchers with access to an using whole-protein mass opportunities for Australian integrated facility for advanced

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characterisation of nanomaterials nanomaterials for biomedical Phoebe Phillips, et al. from inception to application in applications. The facility plans to biomedicine. Nanotechnology has support programs using Pancreatic cancer is a deadly disease contributed to significant advances nanomaterials for molecular imaging that urgently requires better across a range of disciplines and is and intelligent drug delivery, while treatments. A/Prof Phillips, Dr increasingly used in biomedical developing greater understanding of Sharbeen, and their team have applications. The facility aims to allow how to create more effective identified a protein that, when detailed examination of how nanobiomaterials. inhibited, can kill pancreatic cancer nanomaterials interact in biological cells and decrease their resistance to systems; from individual cancer drugs. This project will identify nanoparticles to whole animals, and the mechanism(s) behind these effects. Elucidating the Mechanism by which through developing this fundamental This information will help translate MutY-Homolog Knockdown Kills understanding provide the means to their target into the clinic. Pancreatic Cancer Cells produce new and highly effective

New Way to Target Pancreatic Cancer and Prevent Tumour Growth

A/Prof Phoebe Phillips is exploring a new way to target pancreatic cancer – by reducing the scar tissue around the tumour. This would improve the delivery of drugs to the cancer and prevent further growth. The research is a result of collaboration with Professor Cyrille Boyer as well as Professor Maria Kavallaris and Dr Joshua McCarroll.

Published in the journal Biomacromolecules, the article generated immense media interest both in Australia and overseas.

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High Impact Papers

The Centre continued its great research and publication record in 2016. Our team of researchers published 113 journal articles, 14 of which have impact factors over 10.

Below is a list of Articles with Impact Factors >10

C. Boyer, N. Corrigan, K. Jung, D. driven by solar energy, Science, (9), 3094–3106. [IF 13.0] Nguyen, T. Nguyen, N. Adnan, S. 352 (6289), 1053-1054. [IF 33.5] Oliver, S. Shanmugam, J. Yeow, J. J. Gooding and K. Gaus, 2016, 2016, Bioapplications of Copper K. A. Gilmore, M. W. Lampley, C. Single-Molecule Sensors: Challenges Mediated Living Radical Boyer, E. Harth, 2016, Matrices for and Opportunities for Quantitative Polymerization Atom Transfer combined delivery of proteins and Analysis, Angewandte Chemie - Radical Polymerization & Copper synthetic molecules, Advanced Drug International Edition, 55(38), 11354- Mediated Polymerization, Delivery Reviews, 98, 77-85. [IF15.0] 11366 [IF 11.709] Chemical Reviews, 116, 1803-1949 A. Andres-Arroyo, B. Gupta, F. J. Xu, C. Fu, S. Shanmugam, C. J. [IF 38.5] Wang, J. J. Gooding and P. J. Reece, Hawker, G. Moad, C. Boyer, 2016, J. M. Ren, T. G. McKenzie, Q. Fu, E. 2016, Optical Manipulation and Synthesis of Discrete Oligomers by H. H. Wong, J. Xu, Z. An, S. Spectroscopy of Silicon Sequential PET-RAFT Single-Unit Shanmugam, T. P. Davis, C. Boyer Nanoparticles Exhibiting Dielectric Monomer Insertion. Angewandte and G. G. Qiao, 2016, Star Polymers, Resonances, Nano Letters, 16(3), Chemie International Edition, Chemical Reviews, 116 (12), 6743- 1903-1910. [IF 13.779] December 2016. [IF 11.7] 6836. [IF 37.369] Zhang L; Vogel YB; Noble BB; S. Shanmugam, J. Xu, C Boyer, N. Corrigan, S. Shanmugam, J. Xu, Gonçales VR; Darwish N; Brun AL; 2016, Light‐Regulated C. Boyer, 2016, Photoredox Gooding JJ; Wallace GG; Coote ML; Polymerization under Near‐ Catalysis in Organic and Polymer Ciampi S, 2016, TEMPO Monolayers Infrared/Far‐Red Irradiation Synthesis, Chemical Society on Si(100) Electrodes: Electrostatic Catalyzed by Bacteriochlorophyll a. Reviews, 45, 6165-6212, [IF 35.4] Effects by the Electrolyte and Angewandte Chemie International Semiconductor Space-Charge on Edition, 55, 3, 1036-1040 [IF 11.5] Hinde E; Thammasiraphop K; Duong the Electroactivity of a Persistent HTT; Yeow J; Karagoz B; Boyer C; Radical, Journal of the American J.J. Gooding, 2016, Single Entity Gooding JJ; Gaus, 2016, Pair Chemical Society, 138(30), 9611– Electrochemistry progresses to cell correlation microscopy reveals the 9619. [IF 13.038] counting, Angew. Chem. Int. Ed. 55 role of nanoparticle shape in (42), 12956-12958. [IF >10] intracellular transport and site of J. Xu, S. Shanmugam, C. Fu, K. F. Y.H. Zheng, C. Jiang, S.H. Ng, Y. Lu, F. drug release, Nature Aguey-Zinsou, C. Boyer, 2016, Han, U. Bach, J.J. Gooding, 2016, Nanotechnology. (In Press) [IF Selective Photo-Activation: From Unclonable plasmonic security 35.267] Single Unit Monomer Insertion Reaction to Controlled Polymer labels achieved by shadow-mask- S. Shanmugam, C. Boyer, 2016, Architectures, Journal of the lithography assisted self-assembly, Organocatalyzed polymerization American Chemical Society, 138 Adv. Mater. 28 2330-2336. [IF >10]

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Engagement

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Media

The ACN researchers are dedicated to reaching out beyond the scientific community and have engaged in various television, radio, newspaper, magazine and online interviews; and contributed to newspaper articles and online blogs to promote the Centre and its research. The following list provides a glimpse of the Centre’s extensive media engagement.

A/Prof John McGhee, “Virtual P.S. Khiabani, A.H. Soeriyadi, P.J. - Abomas, Monitoring sun exposure reality explores drug delivery to Reece, J.J. Gooding, A Paper Based with a portable paper sensor, breast cancer cells”. Sensor for Monitor Sun Exposure, 26/5/2016 ACS Sensors 1 775-780 (2016). - New Atlas, Treated paper warns Related media coverage: users of impending sunburn, Related media coverage: 25/5/2016

- SBS, Virtual reality gives patients a - Phys Org, Monitoring sun - ACS Sensors, Monitoring sun room with a view, 11/10/2016 exposure with a portable paper exposure with a portable paper - Australian Financial Review, sensor, 25/5/2016 sensor, 25/5/2016 Virtual reality to spread beyond - Check The Science, Monitoring sun - Science Daily, Monitoring sun games to change the way we live, exposure with a portable paper exposure with a portable paper 8/9/2016 sensor, 26/5/2016 sensor, 25/5/2016 - The Age, Virtual reality trip inside - AZO Sensors, Researchers Develop - Electronics, Portable Paper-Sensor cancer cells can help design better Portable, Paper-Based Sensor for Device Helps Monitor Sun chemotherapy drugs, 16/8/2016 Monitoring Sun Exposure, Exposure, 25/5/2016 - Sydney Morning Herald, Virtual 26/5/2016 - Health Medicine Network, reality trip inside cancer cells can - JDW Insured, Monitoring sun Monitoring sun exposure with a help design better chemotherapy exposure with a portable paper portable paper sensor, 25/5/2016 drugs, 16/8/2016 sensor - Controlled Environments - WIRED, 'Edible' robots and - The Economist, Avoiding Sunburn, Magazine, Portable Paper Sensor batteries you can swallow could Patched Up, 4/6/2016 Monitors Sunburn Risk, 25/5/2016 finally help cure cancer, 23/8/2016 - Science Meets Business, Portable - Engineering and Technology - Mashable Australia, Virtual reality paper sun sensor, 7/6/2016 Magazine, 27/5/2016 allows scientists to walk into a - UNSW Newsroom, Sunburn sensor - MD Linx, A paper-thin idea for a cancer cell,16/8/2016 among top techs at nanomedicine sunburn sensor, 27/5/2016 - UNSW Newsroom, Virtual reality conference, 21/6/2016 - Trend Hunter, Color-Changing explores drug delivery to breast - ABC Radio, New waterproof patch Sunburn Sensors, 30/5/2016 cancer cells,16/8/2016 could alert users to excessive sun - Innovation Toranto, Monitoring - New Scientist, Virtual reality lets exposure, 22/6/2016 sun exposure with a portable you stroll around a breast cancer - Channel 7, New patch provides an paper sensor, 25/5/2016 cell, 1/7/2016 'early warning' against sunburn, - iPR Newswire, Paper UV Sensor - The Australian, Nano cell project: 22/6/2016 Can Monitor Sun Exposure — art meets science to make the - KABC-TV Channel 7, Los Angeles. Market Talk, 25/5/2016 invisible visible, 31/8/2016 - ABC Fantastic Journey , 16/8/2016 - UPI, Paper-based sensor may help - ABC Midday News, 16/8/2016 people avoid overexposure to sun, 26/5/2016 - Science News Line, Monitoring Sun Exposure with a Portable Paper Sensor, 25/5/2016

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E. Hinde, K. Thammasiraphop, Pasquier E, André N, Street J, - Phys.org, Nanotech weapon H.T.T. Duong, J. Yeow, B. Chougule A, Rekhi B, Ghosh J, against chronic bacterial infections Karagoza, C. Boyer, J.J. Gooding, Philip DS, Meurer M, MacKenzie in hospitals, 18/12/2015 K. Gaus, Pair-correlation KL, Kavallaris M, Banavali SD. - Nanotechnology Now, microscopy reveals the role of 2016, 'Effective Management of Nanotechnology Now - Press nanoparticle shape in intracellular Advanced Angiosarcoma by the Release: Nanotech weapon against transport and site of drug release, Synergistic Combination of chronic bacterial infections in Nature Nanotech. (In press) Propranolol and Vinblastine-based hospitals, 18/12/2015 Metronomic Chemotherapy: A - Health Medicinet, Australian Related media coverage: Bench to Bedside Study', researchers develop new EBioMedicine, vol. 6, pp. 87 – 95. technique to combat chronic - Science Daily , Journey to the bacterial infections in hospitals, centre of the cell: Nano-rods and Related Media Coverage: 18/12/2015 worms wriggle best, 12/9/2016 - Infection Control Today, Scientists - COMPAMED, Journey to the - Australian Life Scientist, Blood Develop Nanotech Weapon center of the cell: Nano-rods and pressure drug boosts the effect of Against Chronic Bacterial worms wriggle best, 13/9/2016 chemo, 3/10/2016. Infections, 18/12/2015 - Nano Today, The long and the - Scicasts, Researchers Develop New short of it: Nanoparticle shape Technique to Combat Chronic matters to cells, 1/12/2016 Bacterial Infections in Hospitals - Life Biotechnology, Nano rod and Dr Majid E Warkiani, collaborative - R&D, Nanotech weapon against worm are the best shaped work with MIT on “Electric Field chronic bacterial infections in nanoparticles in cancer drug Cancer Therapy”. hospitals, 18/12/2015 delivery, 16/9/2016 - Medindia, Nanoparticles Used To - Asian Scientist, Nanoparticles Related Media Coverage: Fight Chronic Bacterial Infections Shaped Like Rods & Worms Enter In Hospitals, 18/12/2015 Cell Nucleus More Easily, - MIT News, New microfluidic device - Medical News Today, Nanotech 22/9/2016 offers means for studying electric weapon against chronic bacterial - The Australian, ‘Hotrods’ prove the field cancer therapy, July 5 2016. infections in hospitals, 18/12/2015 best vehicle for nanotech delivery, - Digital Trends, A coin-sized device - Gizmag Emerging Technology 29/9/2016 could have big effect on treating Magazine, Scientists use cancer with electric fields, July 6 nanoparticles to attack chronic 2016. bacterial infections, 18/12/2015 - Science Daily, New microfluidic - KurzweilAI, Magnetic device offers means for studying nanoparticles combat biofilms, a electric field cancer therapy, July 6 source of chronic bacterial 2016. infections, 21/12/2015 - Mariela Cabrera, Iron oxide nanoparticle-mediated hyperthermia stimulates dispersal Nguyen TK; Duong HT T; in bacterial biofilms and enhances Selvanayagam R; Boyer C; Barraud antibiotic efficacy, 23/12/2015 N, 201 5, 'Iron oxide nanoparticle- mediated hyperthermia stimulates dispersal in bacterial biofilms and enhances antibiotic efficacy', Dr Declan Kuch, Medium website, Scientific Reports, vol. 5 Health Data Futures: Prediction, Platforms, Populations, Related Media Coverage: 20/10/2016

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Teo J, McCarroll JA, Boyer, C, reduces pancreatic tumour - Radio Channel 9, Eva Milic, "UNSW Youkhana J, Sagnella SM, Duong growth". scientists have achieved a HT, Liu J, Sharbeen G, Goldstein D, - Research Australia's website. "New breakthrough in the battle against Davis TP, Kavallaris M, Phillips PA. cancer nanomedicine overcomes pancreatic cancer". A rationally optimized nanoparticle drug delivery barrier in pancreatic - Radio 96 FM, "Scientists from system for the delivery of RNA cancer". UNSW have invented a technology interference therapeutics into - Invited article for Inspire which can be used to combat pancreatic tumors in vivo. Magazine. pancreatic cancer". Biomacromolecules,17,2337-51 - TV Channel 9, "Australian medical - TV NBN Lismore, "After 16 years of (2016). researchers are on the verge of a work, Dr Phoebe Phillips and her breakthrough that could team at UNSW has developed a Related media coverage: dramatically reduce deaths from new drug for fighting pancreatic pancreatic cancer". cancer". - Daily Telegraph, "Scientists - Radio 2GB, Alan Jones, "Jones says - Channel 9 Expert Opinion, deserve a gold medal". Sydney scientists have achieved a "Australian scientists are one step - Adelaide Advertiser, "Medical breakthrough in the battle against closer to winning the fight against triumph in war on cancer". pancreatic cancer". pancreatic cancer which claims - Daily Telegraph, "Aussies unlock - Cure Cancer Australia's website, five Australian lives a day". secret of world's deadliest cancer", "Unlocking the Potential to Treat - TV Channel 9, Today Show, Lisa 08 Aug 2016 Pancreatic Cancer". Wilkinson, "Scientists in Sydney - UNSW Newsroom, "New cancer - Medical Republic magazine, "The are claiming a breakthrough in the nanomedicine reduces pancreatic age of programmable cancer battle against pancreatic cancer". tumour growth". drugs", 5th October 2016 - The Western Weekender - ABC Newcastle Radio Interview - TV Channel 9, "An Australian team Newspaper, 'Positive Signs for New with Paul Bevan, "Bevan says has developed a new drug and a Cancer Drug'. researchers from UNSW have way to getting pancreatic cancer - TV NBN Godford, "Five Australians made a breakthrough in the through to tumours" die from pancreatic cancer every treatment of Pancreatic Cancer". - TV Channel 7, Mark Ferguson, day. Doctor Phoebe Phillips and - Radio 2UE, "Interview with Dr "UNSW scientists have achieved a her team at UNSW have Phoebe Phillips, Head, UNSW breakthrough in the battle against developed a new drug and a way Pancreatic Cancer Translational pancreatic cancer". of getting it through to the Research Group, to discuss her - TV Channel 9, Peter Overton, tumours". group's breakthrough in the battle "UNSW scientists have achieved a - The Medical Republic, The age of against pancreatic cancer". breakthrough in the battle against programmable cancer drugs, - Invited article for the Last Post. pancreatic cancer". 5/10/2016. "New cancer nanomedicine

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Events

7th International Nanomedicine Conference

The 7th International Nanomedicine Conference, hosted by the ACN and the CBNS, took place at the Crowne Plaza, Coogee Beach from 27-29 June 2016. This is a key event in the nanomedicine research community and was attended by biologists, clinicians, chemists, material chemists and engineers from around the world.

36 ACN members, post-doctoral researchers, and PhD students presented their research at the Conference, including 11 oral presentations and 25 posters. Congratulations go to 3 of our PhD students Ms Kristel Tjandra, Mr Manish Sriram and Mr Alistair Laos for receiving poster competition prizes. Special thanks go to our conference Support Committee team leaders Dr Robert Utama, Mr Manish Sriram, Mr Vincent Tan and our wonderful team of volunteers who helped make the event successful.

Professor George Whitesides from Professors Justin Gooding & Maria The 3D Imaging workshop at the Harvard University gave a plenary talk at Kavallaris (co-chairs) welcoming Conference attracted great interest the Conference. “Simple/Low-cost plenary speaker Professor Vincent among cancer researchers. Bioanalysis for the Developing World Rotello from University of and Point of Care”. Massachusetts.

Mr Vincent Tan, PhD student from the Mr Walter Muskovic, PhD student Dr David Chang, PhD student from the Gooding group presented his research at from the Kavallaris group discussing Kavallaris group studying posters the conference, “Polymeric hydrogel used research with a fellow Conference during poster session. as an extracellular matrix mimic for 3D delegate. cell culturing”.

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Presentations

The Centre puts great value on the knowledge shared and gained at conferences both local and international. The following is a list of selected talks, seminars and poster presentations in 2016.

Plenary Presentations M. Kavallaris, “Gene silencing in solid for performing voltammetry on a tumours: opportunities and monolithic surface where you want, – Conferences and challenges”, Nanomedicine: Prospects when you want with micron scale for a Brighter Future in Healthcare, spatial resolution, 19th Topical Symposia Mauritius, 01-04 Aug 2016 Meeting of the International Society of Electrochemistry, Auckland, New J.J. Gooding, “Single Entity Sensors: ME Warkiani, Microfluidic Platforms Zealand, 17-20 April 2016. (Financially From Detecting Many to Detecting for Cancer Diagnosis. 2nd Nastran supported) One to Detecting Many” Biosensors International Cancer Symposium, Symposium 2016, Melbourne, 30th September 28-29, 2016, Mashhad, J.J. Gooding, Interdisciplinary November 2016 (Financially Iran. Research involving Chemistry, Physics, Supported) Biology, Mathematics and Engineering: Why I need your help?, J.J. Gooding, Cell based measurement Science Teachers Association New tools to explore therapeutic action , Keynote Talks – South Wales, Annual Conference, Emerging Therapeutics Summit Conferences and University of New South Wales, (ETS’16) Melbourne, Australia 23 – 25 Sydney, 19-20 February 2016. Nov 2016 (Financially supported) Symposia (Financially supported)

J.J. Gooding, S.G. Parker, Y. Yang, S. M. Kavallaris, "Leadership J.J. Gooding, From understanding cell- Ciampi, K. Chuah, Y.F. Wu, Single effectiveness & influencing Culture", material interactions to 3D printing of Entity Electrochemistry: An The Women in STEM Leadership cells, Advanced Manufacturing Electroanalytical Perspective, Summit, Sydney, 23-24 Aug 2016 Summit 2016, Sydney, Australia, 14-15 Electrochem2016, Royal Society of Nov 2016 (Financially supported) Chemistry, Leicester, 17-19 Aug, 2016. M. Kavallaris, "Targeting Aggressive Cancers with Nanoparticle Delivery or (Fully financially supported) R.H. Utama, L. Atapattu, C. Fife, A. RNAi" 1st International Society for O’Mahony, J. Ribeiro, M. Kavallaris, J.J. J.J. Gooding, L.M.H. Lai, I.Y. Goon, K. Nanomedicine Congress, Korea Gooding, The 3D Printing of Cells, 17th Chuah, E. Murago, R. Tavallaie, D.B. University, Seoul, Korea, 28 -30 Sep International Biotechnology Hibbert, Magnetic Nanoparticles As 2016 Symposium and Exhibition, Dispersible Electrodes, ElecNano7, Melbourne, Australia, 24-27 Oct 2016. Lille, France, 23-25 May 2016. M. Kavallaris, “New Therapies for (Financially supported) (Financially supported) Cancer” Nuclear Sciences & Technologies for Health III: A New X. Lu, X.Y. Cheng, T. Tabarin, P.R. M. Kavallaris, “Next Big Thing: Paradigm for Molecular Imaging, Nicovich, K. Gaus, J.J. Gooding, Nanotechnology in Cancer Therapy”, Charles Perkins Centre, University of Towards Single Molecule Biosensors South Australian committee of the Sydney, 14-Nov-16 using super-resolution microscopy, Australian Society for Medical 26th Anniversary World Congress on Research (ASMR), State Scientific Biosensors, Gothenburg, Sweden, 25- Meeting, Adelaide, 8-Jun-16 27 May 2016. (Financially supported) Invited Talks – M. Kavallaris, “Targeting Cancer- M.H. Choudhury, S. Ciampi, S.G. Associated Genes Using Nanoparticle Conferences and Parker, Y. Yang, R. Tavallaie, L. Zarei, Delivery of Gene Silencing”, Emerging V.R. Goncales, J.J. Gooding, Light Therapeutics Summit 2016, Symposia Activated Electrochemistry: A strategy Melbourne, 23-25 Nov 2016 20

J.J. Gooding, Nanotechnology and Technology Bombay, India 25 Jan 2016 May 2016 Biosensors: From Detecting Small (Fully financially supported) Molecules and Drugs to the C Boyer, "Photoredoxcatalysts; An Monitoring of the Activity of Whole M. Kavallaris, “Cancer: Microtubules, efficient Tool for Modern Polymer Cells, Workshop on Advances in drug resistance and Synthesis", MACRO 2016, Istanbul, Biotechnology for Food & Medical nanotherapeutics”, John Curtin School Turkey, 17-21 July 2016. Applications, Sydney University, of Medical Research, Canberra, 4 Nov C Boyer, “Functional nanomaterials”, Sydney, 5-7 Oct 2016. 2016. ACS Conference: American Chemical E. Hinde, K. Thammasiraphop, H.T.T. M. Kavallaris, “Designing Polymer Society Philadelphia, 20-25th August, Duong, J. Yeow, B. Karagoza, C. Boyer, Therapeutics for the Treatment of 2016. (All Expenses Paid) J.J. Gooding, K. Gaus, Pair-correlation Childhood Cancer” 11th International C Boyer, “CO and NO Releasing microscopy reveals the role of Symposium on Polymer Therapeutics Polymers as Antimicrobial Agents”, nanoparticle shape in intracellular (ISPT), Centro de Investigación ACS Conference: American Chemical transport and site of drug release, Príncipe Felipe, Valencia, Spain, 23-25 Society Philadelphia, 20-25th August, Warwick Polymer Conference 2016, May 2016 2016. (All Expenses Paid) Warwick UK, 11-14 July 2016. M. Kavallaris, "Nanoparticle Delivery (Financially supported) to 3D Cell & Animal Models” First C Boyer, “Light responsive materials for controlled delivery”, Zing J.J. Gooding, K. Chuah, E. Murago, R. Summer School of International Conference Polymer Chemistry, Tavallaie, S.M. Silva, D.B. Hibbert, Society for Nanomedicine, Seoul Ireland, 5-9 August 2016. (Partially Magnetic Nanoparticles As Dispersible National University Hospital, Seoul, Funded) Electrodes, 251st American Chemical Korea, 26 – 28 Sep 2016 Society National Meeting, San Diego, M. Kavallaris, “Cancer, Microtubules C Boyer, “Photoredox chemistry for 13-17 March 2016. & Nanomedicine” Houston Methodist polymer synthesis”, World Living Polymerization, Budapest, 29 May – 3 J.J. Gooding, L.M.H. Lai, I.Y. Goon, K. Research Institute, Houston USA, 15 June 2016. (Partially Funded) Chuah, E. Murago, R. Tavallaie, D.B. Apr 2016 Hibbert, Magnetic Nanoparticles As M. Kavallaris, “Delivery Systems for C Boyer, Selective photocatalysis: A Dispersible Electrodes, Pittcon 2016, Cancer Therapy – Why do we need new tool for polymer chemists. Atlanta, 6-10 March 2016. (Financially them” Drug Delivery Australia Emerging Polymer Technologies supported) Conference 2016 – Particles to People, Summit, Melbourne, Australia, 14 – 16 September 2016. M.H. Choudhury, S. Ciampi, Y. Yang, V. Sydney, 27-28 Oct 2016

Gonçales, M.B. Kashi, J.J. Gooding, M. Kavallaris, Australasian J McCarroll, The role of microtubule Switching electrochemistry on and off Pharmaceutical Science Association proteins in regulating tumour growth at monolayer modified silicon (APSA) Annual Scientific Meeting, and chemoresistance. 8th Annual electrodes using light, Centre for “Precision medicine, personalising Garvan Cell Signalling Symposium, Electrochemistry, Annual Workshop healthcare”, Sydney, 2-5 Dec 2016 Oct, 2016, Sydney, Australia. on Electrochemistry, Austin, Texas,

USA, 13-14 February 2016. (Financially O. Vittorio, "Dextran-Catechin J McCarroll, Developing RNA-based supported) conjugate: Targeting copper therapies for the treatment of cancer. metabolism in neuroblastoma”. J.J. Gooding, Next Generation Drug Delivery Australia Conference, Chemistry, Physics and Biosensors: From Detecting Many to Oct, 2016, Sydney, Australia. Nanotechnology, University of Detecting One to Detecting Many, ACS Technology Sydney, Sydney 20th May on Campus, University of Hyderabad, ME Warkiani, The emerging role of 2016. India, 29 Jan 2016 (Fully financially inertial microfluidics in high throughput cell sorting. ACS Annual supported) O. Vittorio, “Dextran-Catechin Conference, Oct 30 – Nov 2, 2016, conjugate: Targeting copper J.J. Gooding, Next Generation Sydney, Australia metabolism in neuroblastoma”. The Biosensors: From Detecting Many to Kids Research Institute, The Children’s Detecting One to Detecting Many, ACS J McCarroll, Beatson Institute, “The Hospital at Westmead, Sydney, 25 on Campus, Indian Institute of role of microtubules in regulating lung

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cancer growth and chemoresistance”, Perth, Australia 2016 Nanotechnology 2016, Canberra, 7-11 Glasgow, Scotland, 6th July 2016 February 2016.

Phillips PA. Targeting the tumour B. McVey, X. Liu, X. Hao, J.J. Gooding, stroma for the treatment of pancreatic Other Oral R. Seed-mediated synthesis and cancer. Beatson International Cancer characterization of Cu quaternary Conference, Glasgow, UK. July, 2016. Presentations chalcogenide nanocrystals, (All travel expenses paid) International Conference of

M. Parviz, K. Gaus, J.J. Gooding, A dual Nanoscience and Nanotechnology M.E. Warkiani, 1st National optical and electrochemical system for 2016, Canberra, 7-11 February 2016. Microfluidic Conference, March 5-6, monitoring cell surface interactions 2016, Tehran, Iran R. Tilley, A. McGrath, S. Cheong, and the response of cells to Zi (Sophia) Gu, Biocompatible therapeutics, The 67th Annual Synthesis of Gold-Palladium layered double hydroxide Meeting of the International Society of Nanoparticles for Hyperthermia nanoparticles for targeted drug Electrochemistry, Den Haag, Cancer Therapy. International delivery and bio-imaging, 7th Netherlands, 21-26 Aug 2016. Conference of Nanoscience and International Nanomedicine Nanotechnology 2016, Canberra, B. Gupta, D. Wakefield, N. Di Conference, Sydney 27-29 June 7-11 February 2016. Girolamo, K. Gaus, P.J. Reece, J.J. 2016. Gooding, In vivo detection of protease L. Gloag, S. Cheong, J.J Gooding, R. activity using porous silicon Tilley, Structural characterisation and microsensors, World Congress on growth study of Au-Ru core-branched Seminars – Universities Biosensors, Gothenburg, Sweden, 25- nanoparticles, International 27 May 2016. Conference of Nanoscience and and Societies Nanotechnology 2016, Canberra, 7-11 V.R. Gonçales, S. Ciampi, J.J. Gooding, February 2016. Effect of different electrolytes of the M. Kavallaris, “Microtubules: Multiple Hofmeister series on SiOx formation at Functions in Cancer Drug Resistance, R. Tavallaie, N. Darwish, D.B. Hibbert, alkyne protected silicon surfaces, 19th Tumourigenesis and Metastasis”, J.J. Gooding, Impact of Single Base pair Topical Meeting of the International Centro de Investigaciones Biologicas, Mismatches on Electron-Transfer Society of Electrochemistry, Auckland, Madrid University, Madrid, Spain, 20 Processes at redox labelled-DNA/RNA New Zealand, 17-20 April 2016. May 2016 Modified Gold Surfaces, International Conference of Nanoscience and P. Sowti, A.H. Soeriyadi, J.J. Gooding, M. Kavallaris, “Cancer, Microtubules Nanotechnology 2016, Canberra, 7-11 A Cheap and Simple Approach to and Nanotherapeutics”, Centre de February 2016. Monitor Sun Exposure based on Recherche en Oncologie biologique et Photocatalytic Properties of Titanium Oncopharmacologie, INSERM, Y.H. Zheng, X. Lu, A.H. Soeriyadi, X.Y. Dioxide, Pittcon 2016, Atlanta, 6-10 University of Marseille, 17 May 2016 Cheng, T. Tabarin, P. Nicovich, L. Rosa, March 2016. S.H. Ng, U. Bach, K. Gaus, J.J. Gooding, Towards Single Molecule Sensors, J McCarroll, Co-Convenor for Kids M. Kashi, Y.F. Wu, V. Goncales, M. International Conference of Cancer Alliance “Emerging Choudhury, S. Ciampi, J.J. Gooding, Nanoscience and Nanotechnology Technology” workshop Dec 9, 2016. Electrochemical Behaviour of Highly- 2016, Canberra, 7-11 February 2016. and Poorly-doped p-Si-AuNP O Vittorio. “Dextran-Catechin Electrodes, Pittcon 2016, Atlanta, 6-10 B. Gupta, D. Wakefield, N. Di conjugate: Targeting copper March 2016. Girolamo, K. Gaus, P.J. Reece, J.J. metabolism in neuroblastoma”. Gooding, Porous Silicon Microsensors Chemistry, Physics and A. Barfidokht, S. Ciampi, E. Luais, N. for the Detection of Protease Activity Nanotechnology, University of Darwish, J.J. Gooding, Distance- In Vivo, International Conference of Technology Sydney, Sydney 20th May Dependent Electron Transfer at Nanoscience and Nanotechnology 2016. Passivated Electrodes Decorated by 2016, Canberra, 7-11 February 2016. Gold Nanoparticles, International M.E. Warkiani, Faculty of Conference of Nanoscience and Engineering, Edith Cowan University,

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R. Piya, B. Gupta, P. J. Reece, J.J. Society for Medical Research (ASMR) Prof Richard Tilley, Solution Synthesis Gooding, Micropatterned Porous NSW State Conference, Sydney, 2016. and Optical Properties of Silicon Silicon Photonic Crystal in Studying Nanocrystals for Biomedical Imaging. Cellular Heterogeneity, International M.E. Warkiani, ANZNMF 7th International Nanomedicine Conference of Nanoscience and conference, Brisbane, Australia 2016 Conference, Sydney, 27-29 June 2016.

Nanotechnology 2016, Canberra, 7-11 M.E. Warkiani, EmTech Asia Mr Vincent Tan, Polymeric hydrogel February 2016. conference, 26-27 January, 2016, used as an extracellular matrix mimic Singapore S.G. Parker, Y. Yang, S. Ciampi, J.J. for 3D cell culturing. 7th International

Gooding, Single-Cell Isolation using M.E. Warkiani, ISCT 2016 Nanomedicine Conference, Sydney, Electrochemically-Switchable Surfaces, conference, May 25-28, 2016, 27-29 June 2016. International Conference of Singapore Nanoscience and Nanotechnology Mr Jonathan Wojciechowski, 2016, Canberra, 7-11 February 2016. Dr Celine Heu, The use of self- Designing Supramolecular Heat-Set assembled hydrogel for the Hydrogels for 3D Cell Culture. 7th O. Vittorio, M. B. Brandl , G. Cirillo, K. development of an in vitro tissue International Nanomedicine Kimpton, E. Hinde, M. Kavallaris boundary 3D tumour model Conference, Sydney, 27-29 June 2016. Dextran-Catechin conjugate targets monitored by Light Sheet Ms Parisa Sowti Khiabani, A Paper copper metabolism in neuroblastoma. Fluorescence Microscopy. 7th Based Sensor for Monitor Sun Advances in Neuroblastoma Research International Nanomedicine Exposure. 7th International Association Meetings, Cairns 2016. Conference, Sydney, 27-29 June 2016. Nanomedicine Conference, Sydney, O. Vittorio, M. B. Brandl , G. Cirillo, K. Dr Bakul Gupta, Detection of Protease 27-29 June 2016. Kimpton, E. Hinde, H. Duong, C. Boyer, Activity using Porous Silicon Photonic M. Kavallaris. Dextran-Catechin Crystals. 7th International conjugate: An anticancer nano- Nanomedicine Conference, Sydney, modified natural compound targeting 27-29 June 2016. copper metabolism in neuroblastoma. Poster Presentations Dr Adam Martin, Controlling self- AACR Annual Meeting 2016 in New Sharbeen G, Youkhana J, Mawson A, assembly in short peptide hydrogels. Orleans, Louisiana. McCarroll J, Akerman A, Goldstein D, 7th International Nanomedicine Phillips PA. MutY-Homolog modulates Sharbeen G, Youkhana J, Mawson A, Conference, Sydney, 27-29 June 2016. pancreatic cancer cell survival and McCarroll J, Akerman A, Goldstein D, chemoresistance. Sydney Cancer and Phillips PA. MutY-homolog Dr Stephen Parker, Single-Cell Conference, 2016. modulates pancreatic cancer cell Isolation using Electrochemically- survival and chemoresistance. The Switchable Surfaces. 7th International Akerman A, Sharbeen G, Holst J, Australasian Pancreatic Club Meeting, Nanomedicine Conference, Sydney, Youkhana J, Naim S, Liu J, McCarroll J, 2016, Sydney, NSW 27-29 June 2016. Goldstein D, Erkan M, Phillips PA. Targeting a solute carrier to Akerman A, Sharbeen G, Holst J, Ms Maryam Parviz, Developing a reprogram tumour-promoting stromal Youkhana J, Naim S, Liu J, McCarroll J, Simultaneous Opto/Electrical cells in pancreatic cancer. Sydney Goldstein D, Erkan M and Phillips PA. Screening System: A More Cancer Conference, 2016. Targeting a solute carrier to Comprehensive methodology to study reprogram tumour-promoting stromal cellular responses. 7th International Sharbeen G, Youkhana J, Mawson A, cells in pancreatic cancer. The Nanomedicine Conference, Sydney, McCarroll J, Akerman A, Goldstein D, Australasian Pancreatic Club Meeting, 27-29 June 2016. Phillips PA. MutY-Homolog modulates 2016, Sydney, NSW. pancreatic cancer cell survival and Dr Roya Tavallaie, Amplified chemoresistance. European Akerman A, Sharbeen G, Holst J, electrochemical detection of Pancreatic Club, Liverpool, UK, 2016. Youkhana J, Naim S, Liu J, McCarroll J, microRNA by interaction of redox Goldstein D, Erkan M, Phillips P. labelled RNA/RNA duplex with p19 Targeting a solute carrier to protein. 7th International reprogram tumour-promoting stromal Nanomedicine Conference, Sydney, cells in pancreatic cancer. Australian 27-29 June 2016.

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ACN members’ poster presentations Ms Mohi Kahram , Electrically Mr Walter Muskovic, Identifying at the 7th International switchable polymers as effective microRNA Therapeutic Targets in Nanomedicine Conference held platforms for smart biosurfaces. Glioblastoma. in Sydney from 27-29 June 2016: Prof Naresh Kumar, Immobilization of Ms Raheleh Pardehkhorram, Quorum Sensing Inhibitors Immuno-Gold Nanorods Composite Mr Abbas Darestani Farahani, Effect Dihydropyrrolones as Antibacterial for Food Safety Monitoring. of Aromatic Capping Group on Packing Coatings. of Amino Acids. Ms Maryam Parviz, Screening the Mr Andrew Robinson, The Effect of effect of a cation-independent Mr Eric Du, Properties of peptide Amino Acid Constituents on the mannose 6-phosphate receptor hydrogels and cardiac stem cells. Properties of Self-assembled Peptide inhibitor, PXS 64, on fibrosis using a Ms Genevieve Duché, Encapsulating Hydrogels for Medical Application. label-free and non-invasive method. self-assembled peptide hydrogels in Mr Alistair Laos, Cooperative subunit Mr Manish Sriram, Single plasmonic liposomes for drug delivery and refolding of a light-harvesting protein particles for digital biosensing. aesthetic therapy. through a self-chaperone mechanism. Ms Kristel Tjandra, Active Targeting of Mr Md Musfizur Hassan, Rational and Mr Ian Lin, Impact of Increasing Doxorubicin through Conjugation to Strategic Design of Hydrogelators for Hydrophilicity on Hydrogel Phage Display-Selected Peptide. Controlled Drug Delivery. Biocompatibility. Dr Robert Utama, Generation of 3D Mr Saimon Moraes Silva, Dr Frieda Mansfeld, An Antibody- Cell Culture Models Using 3D Development of a calibration free Doxorubicin Conjugate to Target Bioprinting. approach for the multiplex microRNA Neuroblastoma Cells. detection in biological fluids based on Dr James Webb, Ultra-Fast Energy the ‘dispersible electrodes’ concept. Mr Alex Mason, Engineered Transfer in Fluorescent Perylene polymersomes with asymmetric Arrays. Mr Robert Healey, Tag-specific and membranes for protein encapsulation. residue-specific fluorescent labelling Mr Chin (Ken) Wong, Anisotropically- of a GPCR protein drug. Ms Manchen Zhao, Using nanoscopy Shaped Fluorescent Polymersomes: with a single-molecule pull-down From Ellipsoids to Tubes Through Fine- Ms Susan Ireland, The Molecular assay based on poly-L-lysine grafted Tuning of π-Stacking Strengths in Pharmacology of the Sweet Taste polyethylene glycol surfaces to Diblock Terpolymers. Receptor. monitor many single protein-protein Ms Duyen Nguyen, Highly Modulated Mr Cheng (Johnson) Jiang, Antifouling interactions. Light-Activated Polymeric Hydrogels featured biosensor: from surface for 3D Cell Culture. chemistry to sensing applications.

Mr Manish Sriram receiving ACS Sensors Poster prize winner Ms Kristel Tjandra Mr Alistair Laos receiving Bioconjugate Poster prize from Editor-in-Chief Professor presenting her poster at Conference. Chemistry poster prize from Editor-in-Chief Justin Gooding. Professor Vince Rotello.

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Collaborating Organisations

The ACN actively pursues research collaboration both within our multi-disciplinary Centre and outside the Centre. Below is a list of our external research collaboration partners in 2016.

ANSTO, Australia Centre, UNSW Center for Radiation Research in Oncology , Germany ARC Centre of Excellence for Monash Institute of Electromaterials Science, Australia Pharmaceutical Sciences, Australia Ruhr Universität Bochum, Germany ARC Centre of Excellence in Monash University, Australia Advanced Molecular Imaging, University of Florence, Italy Australia RR Medsciences Pty Ltd, Australia Victoria University of Wellington, Australian Synchrotron, Australia Sydney Children's Hospital , New Zealand Australia Boron Molecular, Australia Madrid University, Spain University of Newcastle, Australia Children’s Cancer Institute , University of Geneva, Switzerland Australia University of South Australia, Australia Delft University of Technology Clockwerk Pty Ltd, Australia The Netherlands University of Western Australia, CSIRO Manufacturing, Australia Australia Radboud University Nijmegen The Netherlands Deakin University, Australia University of Wollongong, Australia Imperial College London, UK EnGeneic, Australia Victor Chang Cardiac Research University of Liverpool, UK Ettason Pty Ltd, Australia Institute, Australia Beatson Institute, Glasgow European Molecular Biology East China University of Science Scotland, UK Laboratory (EMBL) Australia Node and Technology, China in Single Molecule Science, UNSW Arizona State University, USA Qingdao University, China Flurosol Industries Pty Ltd, Center for Nanotechnology in Australia Xi’an Jiaotong University, China Society, University of California, Santa Barbara, USA Griffith University, Australia German Cancer Consortium (DKTK) Dresden and German Cancer Princeton University, USA Inventia Australia Research Center (DKFZ), Germany University of Texas at Austin, USA Macquarie University, Australia Leibniz Institute of Solid State and Material Research Dresden University of California Davis, USA Mark Wainwright Analytical Germany

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Awards, Prizes and Achievements

There are a number of significant achievements by Centre researchers in 2016. Key achievements are listed below.

On 23 May 2016, ARC Laureate Fellow and Scientia Professor Justin Gooding was elected Fellow of the Australian Academy of Science for his outstanding contributions to science and scientific research.

Justin uses electrochemistry, synthetic chemistry, interfacial physical chemistry, electron transfer theory, protein biochemistry, and cytochemistry, in order to modify surfaces at the molecular level to enable them to specifically recognise biochemical molecules and to transduce that biochemical information to the end user directly within biological fluids. He combines this experience in fundamental bioelectronics with chemometrics to fabricate practical biosensors. His outstanding achievements include the molecular wiring of the enzyme glucose oxidase (a diabetes monitor), molecular wiring of the redox protein cyctochrome-c to silicon, a peptide electrode array to detect bioactive metals, ‘DNA electrodes’, and porous photonic silicon with immobilised peptides able to detect protease activity – aiming for an infection-sensing chip.

Professor Maria Kavallaris was inducted as a Fellow of the Australian Academy of Health and Medical Sciences (AAHMS) on 6 October 2016.

The Fellowship acknowledges Professor Kavallaris as an outstanding research leader who has made seminal discoveries on mechanisms of clinical drug resistance and tumour aggressiveness in childhood and adult cancers. Her world leadership in cancer and microtubules, and her discoveries have led to patents and industry linkages for the development of cancer therapeutics. The honour also recognises Professor Kavallaris’s achievements as a founding Director of the Australian Centre for NanoMedicine at UNSW Australia, an innovative cross- disciplinary initiative developing nanotechnology for medical applications. More broadly, her election as a new Fellow pays tribute to her outstanding leadership in medical research advocacy, peer review, mentoring and advanced research policy.

Professor Cyrille Boyer achieved an unprecedented feat by scooping two prestigious awards: the Journal of Polymer Science Innovation Award and the Biomacromolecules/Macromolecules Young Investigator Award at the 252nd American Chemical Society National Meeting & Exposition on August 21-25, 2016, in Philadelphia, Pennsylvania, U.S.

The awards were in recognition of his outstanding contributions in development of new functional polymers and new nanomaterials for biological applications. Professor Boyer has made major contributions to the field of polymer science, with a body of work focussed on creating novel, specialised polymers utilising living polymerisation. Employing his expertise in polymer chemistry, Professor Boyer has stimulated a paradigm shift in light-activated polymerisation.

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Scientia Professor Justin Gooding Professor Cyrille Boyer Dr William Donald - Elected Fellow of the Australian - 2016 Emerging Investigator by - Awarded the Royal Australian Academy of Science Chemical Society Reviews Chemical Institute (RACI) Peter W. - Elected Fellow of the - 2016 Finalist of University of Alexander Medal for early career International Society of New South Wales Eureka Prize for excellence in Analytical Chemistry on Electrochemistry Scientific Research 18/10/2016 and RACI Physical - Faraday Medal of the Royal - 2016 LeFevre Memorial Prize Chemistry Division Lectureship Society of Chemistry (awarded by the Australian Academy (2016) Electrochemistry Division of Science) - Project leader of one of the five - Royal Society of NSW Walter - 2016 ACS Biomacromolecules/ NSW Smart Sensing Network flagship Burfitt Prize, and the Archibald Macromolecules Award (awarded by projects. Liversidge Medal for 2016 American Chemical Society) - Named Emerging Investigator - Appointed Co-Director of NSW - 2016 Journal of Polymer by the Analyst on 14/10/2016. Smart Sensing Network Science Innovation (awarded by - Named Emerging Investigator - Announced winner of the Wiley) by Journal of the American Society of Biosensors and Bioelectronics Award - Recognised as one of 20 Rising Mass Spectrometry on 9/11/2016. for the most original contribution to Stars at UNSW Biosensors Congress 2016 for his Dr Joshua McCarroll keynote speech “Towards Single Dr Elizabeth Hinde - Cancer Institute NSW Career Molecule Biosensors using super- - Awarded a Cancer Institute Development Fellowship resolution microscopy” NSW Early Career Fellowship Mr Walter Muskovic Professor Maria Kavallaris Dr Majid Ebrahimi Warkiani - Awarded a Brain Foundation - Inducted as a Fellow of the - Awarded the Nanyang grant at the Art Gallery of NSW on 24 Australian Academy of Health and Outstanding Young Alumni Award in Oct 2016. Walter is a tumor biologist Medical Sciences (AAHMS) on 6th Sep 2016 and a PhD student in Maria’s group. October, 2016 Awarded 18th EMBL PhD Symposium - Awarded a prestigious NHMRC A/Prof Phoebe Phillips Heidelberg, Germany November Principle Research Fellowship valued - Invited member of NHMRC 2016 Travel Grant $3,000 at $763,845 for her project entitled: Expert Advisory Grant Committee Precision nanomedicine-based Dr Jason Xu cancer therapeutics. The award was Dr David Chang - Awarded a prestigious ARC announced by Minister for Health on - Awarded Genito-Urinary Future Fellowship for his 4 year 27th October, 2016 Fellowship Grant by The Royal project entitled: Precisely Controlled Australian & New Zealand College of Macromolecular Synthesis through Dr Alex Soeriyadi Radiologists (RANZCR) $25,000. Green and Sustainable - Selected as one of 13 Australian David is a PhD student in Maria’s Chemistry. The award was scientists to tour China as part of the group. announced by Minister for Education Australia-China Young Scientists - Convergent Bio-Nano Science & and Training on 1 November, 2016. Exchange Program (YSEP). Technology Bursary Award – Animal Jason is a postdoc in Cyrille’s group. imaging workshop, Brisbane 26th August 2016

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Governance, Our People & Visitors

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Steering Committee

The Steering Committee provides support, guidance and oversight on strategy and stakeholder engagement as well as monitoring progress towards the delivery of key performance indicators and other objectives. The ACN Steering Committee is chaired by Professor Mark Hoffman (Presiding Dean) and is comprised of members from the associate Faculties of Science and Medicine. The 2016 Steering Committee meetings are noted below.

Steering Committee Members May 2 Sep 5 Dec 1 Professor Mark Hoffman ● ● ● (Chairman) Dean of Engineering, UNSW

Professor Rodney Phillips ● Dean of Medicine, UNSW

Professor Peter Lovibond ● ● ● Dean of Science, UNSW

Scientia Professor Ian Dawes ● ● ● School of Biotechnology and Biomolecular Sciences, UNSW

Scientia Professor Justin Gooding ● ● ● ACN Co-Director School of Chemistry, UNSW

Professor Maria Kavallaris ● ● ● ACN Co-Director Children’s Cancer Institute Australia

Professor Cyrille Boyer ● ● ACN Co-Director School of Chemical Engineering, UNSW

Dr Joshua Peterson ● Interim Centre Manager (Till July 2016) Australian Centre for NanoMedicine

Kimberly Edmunds ● ● Centre Manager (From August 2016) Australian Centre for NanoMedicine

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Organisational Chart

Centre Co-Directors Professors Justin Gooding, Maria Kavallaris and Cyrille Boyer

Centre Manager Kimberly Edmunds

Members Associate Members

Research Associates and PostDocs

Research Students and Honours Students

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ACN Members and Students

Members

Dr Edgar Wong* Scientia Prof A/Prof Matthew VC PostDoc Katharina Gaus Kearnes NHMRC Senior Engineering ARC Future Fellow Research Fellow Medicine Arts & Social Sci

Dr Sophia Gu* Prof Naresh Dr Joshua NHMRC ECR Kumar McCarroll Engineering Science Cancer Institute CDF Fellow Medicine Professor Richard Tilley Dr Majid E Dr Damia Mawad* Science Warkiani Science Engineering

Prof Pall Thordarson

Science Dr. Orazio Vittorio* Dr William (Alex) Donald* Cancer Institute Science ECF Fellow Conjoint Prof Ivan Medicine Greguric ANSTO Life Sciences

Dr Jason Xu* Dr Alex Soeriyadi* ARC Future Fellow A/Prof Phoebe NHMRC ECF Fellow Engineering Phillipps Science UNSW Fellowship Enhancement Package (NHMRC

CDF) Medicine Dr Adam Martin* *2016 new members NHMRC-ARC A/Prof John Dementia Rsch McGhee* Dev Fellow UNSW Art & Design Science

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Associate Members Mr Nat Corrigan Ms Leila Zarei Mr Eric Du Ms Manchen Zhao

Professor Martina Stenzel Ms Genevieve Duche Ms Kelly Zong A/Pro Shelli McAlpine Mr Morphy Dumlao Mr. Kumar Sutradhar* Dr May Lim Mr Sanjun Fan* Ms. Zahara Sadrehani* Dr Renee Whan Mr Abbas Farahani Ms Rashin Zangeneh* Thi Diep Nguyen* Ms Helen Forgham Research Fellows Mr Fei Han Mr Md Musfizur Hassan Honours Students Dr Elizabeth Hinde (Cancer Mr Robert Healey**

Institute ECF) Ms Susan Ireland Mr Peter O’Mara* Dr S R C Vivekchand (VC) Mr Cheng (Johnson) Jiang ** Mr Ian Lin Dr Enrico Klotzsch (VC) Mr Kenward Jung Mr Michael Lawler Dr Yuanhui Zheng (VC) Ms Mohaddeseh Kahram Ms Joy Zhang Dr Hongxu Lu (DECRA) Ms Felicity Kao* Dr. Padmavathy Bakthavathsalam Ms Aria Ahmed Cox Mr Alexander Kross (Trust-India Fellow) Gervase Ng* Ms Joanna Kwiatek Dr. Yuhua Xue (VC) Henry Xu* Mr Alistair Laos** Peter Judzewitsch* Mr Xun Lu **

Post Docs Mr Yong (Jerry) Lu (till Nov 2016) Centre Administration Dr Celine Heu (till Dec 2016) Mr Alex (Yuanqing) Ma Dr Declan Kuch Mr Alex Mason** Kimberly Edmunds Dr Frieda Mansfeld Ms Mahdie Mollazade** Centre Manager (From Aug 2016) Dr James Webb Mr Saimon Moraes Silva Dr Miriam Brandl (till Sep 2016) Mr Walter Muskovic Dr Joshua Peterson Research Officer Dr Guillaume Longatte Ms Khanh Nguyen

Dr Stephen Parker Ms Duyen Nguyen* Mr Eh Hau Pan Dr Roya Tavallaie Ms Susan Oliver Lab Manager Dr Robert Utama Ms Amelia Parker**

Dr Lakmali Atapattu (from Mar 2016) Ms Rahelleh Pardekhorram Ms Kathleen Kimpton Dr Christopher Fife (till Mar 2016) Ms Maryam Parviz ** Research Assistant Dr James Webb(till Dec 2016) Ms Ranjana Piya Dr Wee Teo Mr Bijan Pouryousefi Markhali* Ms Tara McGilligan Dr Amelia Parker(from Jan 2016) Mr Mehdi Rafeie EA to Prof Kavallaris (till Dec 2016) Dr Sela Po’uha Mr Abu Sadat Md. Sayem Rahman Mr Siva Shanmugam Mrs Jesu Schlogl EA to Prof Kavallaris (from Dec 2016) PhD Students Mr Saimon Silva*

Ms Parisa Sowti Ms Rose-Marie Olsson Mr Manish Sriram Mr Nik Nik Mohd Adnan Senior Research Assistant Ms Laura Jeffress Mr Vincent Tan Ms Anouschka Akerman Ms Safura Taufik* Mrs Sona Samuels Ms Fida’a Alshawawreh* Ms Kristel Tjandra Research Assistant Ms Sri Augustina Mr Jason Tran Mr Ali Bagheri Mr Jonathan Wojciechowski Ms Efremova Varvara Research Assistant Mr Kumar Bishwajit Mr Chin (Ken) Wong

Mr Zhenbang Cao Mr Yanfang Wu *joined in 2016 Mr Lachlan Carter Mr Ming Han Eugene Yee ** graduated in 2016 Dr David Chang Mr Jonathan Yeow 32

Visitors to the ACN

The ACN has hosted a diverse range of visitors from academia and industry within Australia and around the world during 2016. Our visitors have presented seminars and met with research staff and students to investigate potential collaboration opportunities.

A/Professor Ross Dickins Professor Brandon Wainwright Professor Volga Bulmis Laboratory Head Director, Inst for Molecular Bioscience Izmir Institute of Technology Aust Ctr for Blood Diseases The University of Queensland Turkey Monash University Australia Professor Swaminathan Iyer Prof James Wilsdon Dr Belinda Parker ARC Future Fellow Sheffield University UK ARC Future Fellow University of Western Australia Latrobe University Australia Dr Jane Calvert Dr Toby Bell University of Edinburgh UK Professor David Huang Monash University Australia Laboratory Head Prof Véronique Gouverneur Cancer and Haematology Dr Annette Kunkele Oxford University UK Walter and Eliza Hall Institute of Charité Universitätsmedizin Medical Research Australia Berlin Germany Prof Arieh Warshel University of Southern California Dr Charles Farnsworth Dr Markus Elsner USA Senior Proteomics Applications Senior Editor Scientist Nature Biotechnology Germany A/Prof Diana M Bowman Cell Signalling Technology Australia Arizona State University USA Dr Peter Gölitz Dr Paul Timpson Editor-in-Chief of Angewandte Chemie Dr Tito Fojo Lab Head - Invasion and Metastasis Wiley-VCH Germany Columbia University Medical Centre Garvan Institute of Medical USA Research Australia Professor Angelika Eggert Berlin School of Integrative Prof Felix Castellano Dr Samir Taoudi Oncology Germany North Carolina State University Lab Head – Molecular Medicine USA Walter and Eliza Hall Institute of Prof Addy Pross Medical Research Australia Ben-Gurion University of the Negev Prof George Whitesides Israel Harvard University USA Prof Michelle Coote Fellow of Aust Academy of Science Dr Giuseppe Cirillo Dr Jack London Australian National University The University of Calabria Italy Thomas Jefferson University USA Prof Gail Risbridger Prof Keji Maruoka NHMRC Senior Principal Research Kyoto University Japan Prof Vince Rotello Fellow University of Massachusetts Amherst Peter MacCallum Cancer Centre Prof Bronwyn Parry USA Australia King's College London Dr Curtis Harris Prof James Camakaris Prof Eric Bakker National Cancer Institute USA The University of Melbourne University of Geenva Switzerland

Prof Phillip Robinson Prof Jan H van Esch Delft Head, Cell Signalling Unit University of Technology Children's Medical Research Institute The Netherlands NSW

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Publications

Books/Book and Composite Materials, E; Schmidt TW; Duong HTT; Springer Int Publishing Ag, pp. Boyer C, 2016, 'Effect of gold Chapters 19 – 44. nanoparticle shapes for phototherapy and drug Chilvers J; Kearnes MB, (eds.), Silva SM; Justin Gooding J, delivery', Polymer Chemistry, 2016, Remaking Participation: 2016, 'Chapter 8: Dispersible vol. 7, pp. 2888 – 2903. Science, Environment and electrodes: An approach to Emergent Publics, Routledge, developing sensing devices Akerman A; Vennin C; Sharbeen Abingdon, Oxon OX14 4RN that can quickly detect G; Warren SC; Timpson P; ultralow concentrations of Phillips PA, 2016, 'Novel Chilvers J;Kearnes M, 2016, analyte', in RSC Detection therapeutics and preclinical 'Science, democracy and Science, edn. 6, pp. 279 – 295. imaging for pancreatic cancer - emergent publics', in View from the lab', Cancer Byrne, F. L., McCarroll, J. A., Remaking Participation: Forum, vol. 40, pp. 16 – 22. and Kavallaris, M. (2016) Science, Environment and Analyses of tumor burden in Emergent Publics, pp. 1 – 27. Al-Eisawi Z; Stefani C; Jansson vivo and metastasis ex vivo PJ; Arvind A; Sharpe PC; Basha using luciferase-expressing Chilvers J;Kearnes M, 2016, MT; Iskander GM; Kumar N; cancer cells in an orthotopic 'Remaking participation: Kovacevic Z; Lane DJR, 2016, mouse model of Towards reflexive 'Novel Mechanism of neuroblastoma, In Methods in engagement', in Remaking Cytotoxicity for the Selective Molecular Biology, pp 61-77. Participation: Science, Selenosemi-carbazone, 2- Environment and Emergent Mansfeld F M, Davis TP, Acetylpyridine 4, 4-Dimethyl-3- Publics, pp. 261 – 288. Kavallaris M (2016), selenosemicarbazone “Nanotechnology in Medical (Ap44mSe): Lysosomal Chilvers J;Kearnes M, 2016, Research”. Micro and Membrane Permeabilization', 'Participation in the making: nanotechnologies for vaccine Journal of Medicinal Chemistry, Rethinking public engagement development, pp. 21 – 45. vol. 59, pp. 294 – 312. in co-productionist terms', in Remaking Participation: Andres-Arroyo A; Gupta B; Science, Environment and Journal Articles Wang F; Gooding JJ; Reece PJ, Emergent Publics, pp. 31 - 63, 2016, 'Optical Manipulation and

Spectroscopy of Silicon Abu-Siniyeh A; Owen DM; Sharbeen G; McAlpine S; Nanoparticles Exhibiting Benzing C; Rinkwitz S; Becker Phillips P, 2016, 'HSP47: The Dielectric Resonances', Nano TS; Majumdar A; Gaus K, 2016, new heat shock protein Letters, vol. 16, pp. 1903 – 1910. 'The aPKC/Par3/Par6 Polarity therapeutic target', in Topics Complex and Membrane in Medicinal Chemistry, pp. Asadnia M; Kottapalli AGP; Order Are Functionally 197 – 220. Karavitaki KD; Warkiani ME; Interdependent in Epithelia Miao J; Corey DP; Triantafyllou During Vertebrate Mawad D; Lauto A; Wallace M, 2016, 'From Biological Cilia Organogenesis', Traffic, vol. GG, 2016, 'Conductive to Artificial Flow Sensors: 17, pp. 66 – 79. Polymer Hydrogels', in Kalia S Biomimetic Soft Polymer

(ed.), Polymeric Hydrogels As Nanosensors with High Sensing Adnan NNM; Cheng YY; Ong Smart Biomaterials, edn. Performance', Scientific Reports, NMN; Kamaruddin TT; Rozlan Springer Series on Polymer vol. 6.

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Bagheri A; Arandiyan H; Boyer C; MM; Gardner CR; Black DS; Sustained Cancer Treatment', Lim M, 2016, 'Lanthanide-doped Kumar N, 2016, 'Synthesis of ACS Applied Materials and upconversion nanoparticles: brominated novel N- Interfaces, vol. 8, pp. 15857 – Emerging intelligent light- heterocycles: New scaffolds for 15863. activated drug delivery systems', antimicrobial discovery', Advanced Science, vol. 3. Tetrahedron, vol. 72, pp. 539 – Cornely R; Pollock AH; Rentero 546. C; Norris SE; Alvarez-Guaita A; Bagheri A; Yeow J; Arandiyan H; Grewal T; Mitchell T; Enrich C; Xu J; Boyer C; Lim M, 2016, Boyer C; Corrigan NA; Jung K; Moss SE; Parton RG, 2016, 'Macromol. Rapid Commun. Nguyen D; Nguyen T-K; Adnan 'Annexin A6 regulates 11/2016.', Macromol Rapid NNM; Oliver S; Shanmugam S; interleukin-2-mediated T-cell Commun, vol. 37, pp. 940. Yeow J, 2016, 'Copper-Mediated proliferation', Immunology Living Radical Polymerization and Cell Biology, vol. 94, pp. Bagheri A; Yeow J; Arandiyan H; (Atom Transfer Radical 543 – 553. Xu J; Boyer C; Lim M, 2016, Polymerization and Copper(0) 'Polymerization of a Mediated Polymerization): From Corrigan N; Rosli D; Jones JWJ; Photocleavable Monomer Using Fundamentals to Xu J; Boyer C, 2016, 'Oxygen Visible Light', Macromolecular Bioapplications', Chem Rev, vol. Tolerance in Living Radical Rapid Communications. vol. 37, 116, pp. 1803 – 1949. Polymerization: Investigation pp. 905 – 910. of Mechanism and Chaudhuri PK; Ebrahimi Implementation in Continuous Banik R; Roy S; Dlháň Ľ; Titiš J; Warkiani M; Jing T; Kenry; Lim Flow Polymerization’, Boča R; Kirillov AM; Martin AD; CT, 2016, 'Microfluidics for Macromolecules, vol. 49, pp. Bauza A; Frontera A; Rodríguez- research and applications in 6779 – 6789. Diéguez A, 2016, 'Self-assembly oncology', Analyst, vol. 141, pp. synthesis, structure, topology, 504 – 524. Corrigan N; Shanmugam S; Xu and magnetic properties of a J; Boyer C, 2016, mononuclear Fe( iii )-violurate Chen R; Cole N; Dutta D; Kumar 'Photocatalysis in organic and derivative: a combined N; Willcox MDP, 2016, polymer synthesis’, Chem Soc experimental and theoretical 'Antimicrobial activity of Rev, vol. 45, pp. 6165 – 6212. study', Dalton Trans., vol. 45, immobilized lactoferrin and pp. 16166 – 16172. lactoferricin', Journal of Corrigan N; Xu J; Boyer C, Biomedical Materials Research - 2016, 'A Photoinitiation Bingul M; Kumar N; Black DS, Part B Applied Biomaterials. System for Conventional and 2016, 'Synthesis and reactions Controlled Radical of new 2-hydroxymethyldime- Chen R; Willcox MDP; Ho KKK; Polymerization at Visible and thoxyindoles', Tetrahedron, vol. Smyth D; Kumar N, 2016, NIR wavelengths', 72, pp. 234 – 239. 'Antimicrobial peptide melimine Macromolecules, vol. 49, pp. coating for titanium and its in 3274 – 3285. Bingul M; Tan O; Gardner CR; vivo antibacterial activity in Sutton SK; Arndt GM; Marshall rodent subcutaneous infection De Sousa DP; Wegeberg C; GM; Cheung BB; Kumar N; Black models', Biomaterials, vol. 85, Vad MS; Mørup S; Frandsen C; DSC, 2016, 'Synthesis, pp. 142 – 151. Donald WA; McKenzie CJ, characterization and anti-cancer 2016, 'Halogen-Bonding- activity of hydrazide derivatives Chen X; Liu Z; Parker SG; Zhang Assisted Iodosylbenzene incorporating a quinoline X; Gooding JJ; Ru Y; Liu Y; Zhou Activation by a Homogenous moiety', Molecules, vol. 21. Y, 2016, 'Light-Induced Hydrogel Iron Catalyst', Chemistry - A Based on Tumor-Targeting European Journal, vol. 22, pp. Biswas NN; Kutty SK; Iskander Mesoporous Silica Nanoparticles 3810 – 3820. GM; Mielczarek M; Bhadbhade as a Theranostic Platform for

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Dumlao MC; Jeffress LE; Fu C; Xu J; Kokotovic M; Boyer Gonçales VR; Wu Y; Gupta B; Gooding JJ; Donald WA, 2016, C, 2016, 'One-Pot Synthesis of Parker SG; Yang Y; Ciampi S; 'Solid-phase microextraction Block Copolymers by Tilley R; Gooding JJ, 2016, low temperature plasma mass Orthogonal Ring-Opening 'Stability of Chemically spectrometry for the direct Polymerization and PET-RAFT Passivated Silicon Electrodes and rapid analysis of chemical Polymerization at Ambient in Aqueous Solutions: warfare simulants in complex Temperature', ACS Macro Interplay between Bias mixtures', Analyst, vol. 141, Letters, vol. 5, pp. 444 – 449. Voltage and Hydration of the pp. 3714 – 3721. Electrolyte', Journal of Physical Gaus K, 2016, 'Biologists Chemistry C, vol. 120, pp. Dutta D; Kumar N; D P Willcox Wanted: New Fluorescence 15941 – 15948. M, 2016, 'Antimicrobial Fluctuation Tools for Cell activity of four cationic Biology', Biophysical Journal, Gooding JJ; Gaus K, 2016, peptides immobilised to poly- vol. 111, pp. 677 – 678. 'Single-Molecule Sensors: hydroxyethylmethacrylate’, Challenges and Opportunities Biofouling, vol. 32, pp. 429 – Gaus K; Inoue T, 2016, 'New for Quantitative Analysis', 438. Biological Frontiers Angewandte Chemie - Illuminated by Molecular International Edition. Dutta D; Vijay AK; Kumar N; Sensors and Actuators', Willcox MDP, 2016, 'Melimine- Biophysical Journal, vol. 111, Gunawan CA; Nam EV; coated antimicrobial contact pp. E01 - E02. Marquis CP; Gooding JJ; lenses reduce microbial Thordarson P; Zhao C, 2016, keratitis in an animal Gebala M; La Mantia F; 'Scanning Electrochemical model', Investigative Michaels PE; Ciampi S; Gupta Microscopy of Cytochrome c Ophthalmology and Visual B; Parker SG; Tavallaie R; Peroxidase through the Science, vol. 57, pp. 5616 – Gooding JJ, 2016, 'Electric Orientation-Controlled 5624. Field Modulation of Silicon Immobilisation of Cytochrome upon Tethering of Highly c', ChemElectroChem, vol. 3, Frost SJ; Mawad D; Higgins MJ; Charged Nucleic Acids. pp. 1150 – 1156. Ruprai H; Kuchel R; Tilley RD; Capacitive Studies on DNA- Myers S; Hook JM; Lauto A, modified Silicon (111)', Han F; Soeriyadi AH; 2016, 'Gecko-inspired chitosan Electroanalysis, vol. 28, pp. Vivekchand SRC; Gooding JJ, adhesive for tissue repair', 2367 – 2372. 2016, 'Simple Method for NPG ASIA MATERIALS, vol. 8. Tuning the Optical Properties Gerami A; Mostaghimi P; of Thermoresponsive Frost SJ; Mawad D; Hook J; Armstrong RT; Zamani A; Plasmonic Nanogels', ACS Lauto A, 2016, 'Micro- and Warkiani ME, 2016, 'A Macro Letters, vol. 5, pp. 626 – Nanostructured Biomaterials microfluidic framework for 630. for Sutureless Tissue Repair', studying relative permeability Advanced Healthcare in coal', International Journal Hassanzadeh-Barforoushi A; Materials. of Coal Geology, vol. 159, pp. Shemesh J; Farbehi N; Asadnia 183 – 193. M; Yeoh GH; Harvey RP; Fu C; Xu J; Boyer C, 2016, Nordon RE; Warkiani ME, 'Photoacid-mediated ring Gilmore KA; Lampley MW; 2016, 'A rapid co-culture opening polymerization driven Boyer C; Harth E, 2016, stamping device for studying by visible light', Chemical 'Matrices for combined intercellular communication', Communications, vol. 52, pp. delivery of proteins and Scientific Reports, vol. 6. 7126 – 7129. synthetic molecules', Advanced Drug Delivery Hervault A; Dunn AE; Lim M; Reviews, vol. 98, pp. 77 – 85. Boyer C; Mott D; Maenosono

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S; Thanh NTK, 2016, Langmuir, vol. 32, pp. 2509 – producing reactive oxygen 'Doxorubicin loaded dual pH- 2517. species that damage biological and thermo-responsive molecules', Frontiers in magnetic nanocarrier for Kandemir H; Sengul IF; Kumar Microbiology, vol. 7. combined magnetic N; Black DSC, 2016, 'Synthesis hyperthermia and targeted of a 7-(aminomethyl)indole Kimyon Ö; Ulutürk ZI; controlled drug delivery and related bis-indole Nizalapur S; Lee M; Kutty SK; applications', Nanoscale, vol. derivatives', Arkivoc, vol. 2016, Beckmann S; Kumar N; 8, pp. 12152 – 12161. pp. 288 – 295. Manefield M, 2016, 'N- acetylglucosamine inhibits Hesari Z; Soleimani M; Atyabi Kapoor-Kaushik N; Hinde E; LuxR, LasR and CviR based F; Sharifdini M; Nadri S; Compeer EB; Yamamoto Y; quorum sensing regulated Warkiani ME; Zare M; Kraus F; Yang Z; Lou J; Pageon gene expression levels', Dinarvand R, 2016, 'A hybrid SV; Tabarin T; Gaus K, 2016, Frontiers in Microbiology, vol. microfluidic system for 'Distinct mechanisms regulate 7. regulation of neural Lck spatial organization in differentiation in induced activated T cells', Frontiers in Kulasinghe A; Perry C; pluripotent stem cells', Journal Immunology, vol. 7. Warkiani ME; Blick T; Davies A; of Biomedical Materials O'Byrne K; Thompson EW; Research - Part A, vol. 104, pp. Kashi MB; Wu Y; Gonçales VR; Nelson CC; Vela I; Punyadeera 1534 – 1543. Choudhury MH; Ciampi S; C, 2016, 'Short term ex-vivo Gooding JJ, 2016, 'Silicon– expansion of circulating head Hinde E; Pand E; Yang Z; Ng SAM–AuNP electrodes: and neck tumour cells', IHW; Jans DA; Bogoyevitch Electrochemical “switching” Oncotarget, vol. 7, pp. 60101 – MA; Gratton E; Gaus K, 2016, and stability', Electrochemistry 60109. 'Quantifying the dynamics of Communications, vol. 70, pp. the oligomeric transcription 28 – 32. Li L; Gu Z; Gu W; Liu J; Xu ZP, factor STAT3 by pair 2016, 'Efficient drug delivery correlation of molecular Khiabani PS; Soeriyadi AH; using SiO2-layered double brightness', Nature Reece PJ; Gooding JJ, 2016, hydroxide nanocomposites', Communications, vol. 7. 'Paper-Based Sensor for Journal of Colloid and Monitoring Sun Exposure', ACS Interface Science, vol. 470, pp. Hinde E; Thammasiraphop K; Sensors, vol. 1, pp. 775 – 780. 47 – 55. Duong HTT; Yeow J; Karagoz B; Boyer C; Gooding JJ; Gaus K, Khoo BL; Chaudhuri PK; Li L; Gu Z; Gu WY; Xu ZP, 2016, 2016, 'Pair correlation Ramalingam N; Tan DSW; Lim 'Direct synthesis of layered microscopy reveals the role of CT; Warkiani ME, 2016, double hydroxide nanosheets nanoparticle shape in 'Single-cell profiling for efficient siRNA delivery', intracellular transport and site approaches to probing tumor RSC Advances, vol. 6, pp. of drug release', Nature heterogeneity', International 95518 – 95526. Nanotechnology. Journal of Cancer, vol. 139, pp. 243 – 255. Liana AE; Chia EW; Marquis Jiang C; Alam MT; Parker SG; CP; Gunawan C; Gooding JJ; Darwish N; Gooding JJ, 2016, Kimyon Ö; Das T; Ibugo AI; Amal R, 2016, 'Adsorption of 'Strategies to Achieve Control Kutty SK; Ho KK; Tebben J; T4 bacteriophages on planar over the Surface Ratio of Two Kumar N; Manefield M, 2016, indium tin oxide surface via Different Components on 'Serratia secondary metabolite controlled surface tailoring', Modified Electrodes Using prodigiosin inhibits Journal of Colloid and Aryldiazonium Salts', Pseudomon as aeruginosa Interface Science, vol. 468, pp. biofilm development by 192 – 199.

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Liu M; Xu Y; Niu F; Gooding JJ; Responsive Pore-Cap for Poly(Ethylenedioxy Liu J, 2016, 'Carbon quantum Targeted Imaging and Drug Thiophene)', Chemistry of dots directly generated from Delivery to Tumor', Advanced Materials, vol. 28, pp. 6080 – electrochemical oxidation of Healthcare Materials, vol. 5, 6088. graphite electrodes in alkaline pp. 1380. alcohols and the applications McKenzie TG; Fu Q; Uchiyama for specific ferric ion detection Lu Y; Peterson JR; Luais E; M; Satoh K; Xu J; Boyer C; and cell imaging', Analyst, vol. Gooding JJ; Lee NA, 2016, Kamigaito M; Qiao GG, 2016, 141, pp. 2657 – 2664. 'Effects of surface epitope 'Controlled Polymerization: coverage on the sensitivity of Beyond Traditional RAFT: Liu PY;Sokolowski N;Guo displacement assays that Alternative Activation of ST;Siddiqi F;Atmadibrata employ modified Thiocarbonylthio Compounds B;Telfer TJ;Sun Y;Zhang L;Yu nanoparticles: Using bisphenol for Controlled Polymerization, D;Mccarroll J;Liu B;Yang a as a model analyte', Advanced Science, vol. 3. RH;Guo XY;Tee AE;Itoh Biosensors, vol. 6. K;Wang J;Kavallaris M;Haber McKenzie TG; Ren JM; M;Norris MD;Cheung Ma Y; Benda A; Nicovich PR; Dunstan DE; Wong EHH; Qiao BB;Byrne JA;Ziegler Gaus K, 2016, 'Measuring GG, 2016, 'Synthesis of high- DS;Marshall GM;Dinger membrane association and order multiblock core cross- ME;Codd R;Zhang XD;Liu T, protein diffusion within linked star polymers', Journal 2016, 'The BET bromodomain membranes with supercritical of Polymer Science Part A: inhibitor exerts the most angle fluorescence Polymer Chemistry, vol. 54, pp. potent synergistic anticancer microscopy', Biomedical Optics 135 – 143. effects with quinone- Express, vol. 7, pp. 1561 – containing compounds and 1576. Mcvey BFP; Prabakar S; anti-microtubule drugs', Gooding JJ; Tilley RD, 2016, Oncotarget, vol. 7, pp. 79217 – Martin AD; Wojciechowski JP; 'Solution Synthesis, Surface 79232. Bhadbhade MM; Thordarson Passivation, Optical P, 2016, 'A Capped Dipeptide Properties, Biomedical Liu Z; Chen X; Zhang X; Which Simultaneously Exhibits Applications, and Cytotoxicity Gooding JJ; Zhou Y, 2016, Gelation and Crystallization of Silicon and Germanium 'Carbon-Quantum-Dots- Behavior', Langmuir, vol. 32, Nanocrystals', ChemPlusChem. Loaded Mesoporous Silica pp. 2245 – 2250. Nanocarriers with pH- Moraes Silva S; Tavallaie R; Switchable Zwitterionic Martin AD; Wojciechowski JP; Sandiford L; Tilley RD; Gooding Surface and Enzyme- Warren H; In Het Panhuis M; JJ, 2016, 'Gold coated Responsive Pore-Cap for Thordarson P, 2016, 'Effect of magnetic nanoparticles: From Targeted Imaging and Drug heterocyclic capping groups preparation to surface Delivery to Tumor', Advanced on the self-assembly of a modification for analytical and Healthcare Materials, vol. 5, dipeptide hydrogel', Soft biomedical applications', pp. 1401 – 1407. Matter, vol. 12, pp. 2700 – Chemical Communications, 2707. vol. 52, pp. 7528 - 7540 Liu Z; Chen X; Zhang X; Gooding JJ; Zhou Y, 2016, Mawad D; Artzy-Schnirman A; MoraesSilva S; Tavallaie R; 'Targeted Drug Delivery: Tonkin J; Ramos J; Inal S; TanzirulAlam M; Chuah K; Carbon-Quantum-Dots-Loaded Mahat MM; Darwish N; Zwi- Gooding JJ, 2016, 'A Mesoporous Silica Dantsis L; Malliaras GG; Comparison of Differently Nanocarriers with pH- Gooding JJ, 2016, Synthesized Gold-coated Switchable Zwitterionic 'Electroconductive Hydrogel Magnetic Nanoparticles as Surface and Enzyme- Based on Functional 'Dispersible Electrodes'',

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Electroanalysis, vol. 28, pp. Rice SA; Manefield M; Willcox Philip DS, Meurer M, 431 – 438. M; Black DS; Kumar N, 2016, MacKenzie KL, Kavallaris M, 'Design, synthesis and Banavali SD. 2016, 'Effective Nguyen D; Adnan NNM; Oliver evaluation of N-aryl- Management of Advanced S; Boyer C, 2016, 'The glyoxamide derivatives as Angiosarcoma by the Interaction of CORM-2 with structurally novel bacterial Synergistic Combination of Block Copolymers Containing quorum sensing inhibitors', Propranolol and Vinblastine- Poly(4-vinylpyridine): Organic & Biomolecular based Metronomic Macromolecular Scaffolds for Chemistry, vol. 14, pp. 680 – Chemotherapy: A Bench to Carbon Monoxide Delivery in 693. Bedside Study', EBioMedicine, Biological Systems’, vol. 6, pp. 87 – 95. Macromolecular Rapid Oliver S; Thomas DS; Kavallaris Communications, vol. 37, pp. M; Vittorio O; Boyer C, 2016, Pavlovic M; Li L; Dits F; Gu Z; 739 – 744. 'Efficient functionalisation of Adok-Sipiczki M; Szilagyi I, dextran-aldehyde with 2016, 'Aggregation of layered Nguyen D; Oliver S; Adnan catechin: Potential double hydroxide NNM; Herbert C; Boyer C, applications in the treatment nanoparticles in the presence 2016, 'Polymer-protein hybrid of cancer', Polymer Chemistry, of heparin: towards highly scaffolds as carriers for CORM- vol. 7, pp. 2542 – 2552. stable delivery systems', 3: Platforms for the delivery of RSC Advances, vol. 6, pp. carbon monoxide (CO)', RSC Oliver S; Vittorio O; Cirillo G; 16159 – 16167. Advances, vol. 6, pp. 92975 – Boyer C, 2016, 'Enhancing the 92980. therapeutic effects of Pollock AH; Tedla N; Hancock polyphenols with SE; Cornely R; Mitchell TW; Nguyen TK; Selvanayagam R; macromolecules', Polymer Yang Z; Kockx M; Parton RG; Ho KKK; Chen R; Kutty SK; Rice Chemistry, vol. 7, pp. 1529 – Rossy J; Gaus K, 2016, SA; Kumar N; Barraud N; 1544. 'Prolonged intake of dietary Duong HTT; Boyer C, 2016, lipids alters membrane 'Co-delivery of nitric oxide and Ozcelik B; Chen R; Glattauer V; structure and T cell responses antibiotic using polymeric Kumar N; Willcox MP; Thissen in LDLr-/-mice', Journal of nanoparticles', Chemical H, 2016, 'Crosslinked Platform Immunology, vol. 196, pp. Science, vol. 7, pp. 1016 – Coatings Incorporating 3993 – 4002. 1027. Bioactive Signals for the Control of Biointerfacial Rafeie M; Zhang J; Asadnia M; Nizalapur S; Ho KKK; Kimyon Interactions', Macromolecular Li W; Warkiani ME, 2016, Ö; Yee E; Berry T; Manefield Bioscience. 'Multiplexing slanted spiral M; Cranfield CG; Willcox M; microchannels for ultra-fast Black DSC; Kumar N, 2016, Parker AL, Turner N, McCarroll blood plasma separation', Lab 'Synthesis and biological JA, Kavallaris M., 2016, 'βIII- on a Chip - Miniaturisation for evaluation of N-naphthoyl- Tubulin alters glucose Chemistry and Biology, vol. 16, phenylglyoxamide-based small metabolism and stress pp. 2791 – 2802. molecular antimicrobial response signaling to promote peptide mimics as novel cell survival and proliferation Ramalingam N; Warkiani ME; antimicrobial agents and in glucose-starved non-small Ramalingam N; Keshavarzi G; biofilm inhibitors', Organic cell lung cancer cells', Hao-Bing L; Hai-Qing TG, 2016, and Biomolecular Chemistry, Carcinogenesis, vol. 37, pp. 'Numerical and experimental vol. 14, pp. 3623 – 3637. 787 – 798 study of capillary-driven flow of PCR solution in hybrid Nizalapur S; Kimyon O; Biswas Pasquier E, André N, Street J, hydrophobic microfluidic NN; Gardner CR; Griffith R; Chougule A, Rekhi B, Ghosh J,

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networks', Biomedical 2016, 'Delineating the Role of Thach O; Mielczarek M; Ma C; Microdevices, vol. 18. βIV-Tubulins in Pancreatic Kutty SK; Yang X; Black DSC; Cancer: βIVb-Tubulin Griffith R; Lewis PJ; Kumar N, Ren JM; McKenzie TG; Fu Q; Inhibition Sensitizes Pancreatic 2016, 'From indole to pyrrole, Wong EHH; Xu J; An Z; Cancer Cells to Vinca furan, thiophene and pyridine: Shanmugam S; Davis TP; Boyer Alkaloids', Neoplasia, vol. 18, Search for novel small C; Qiao GG, 2016, 'Star pp. 753 – 764. molecule inhibitors of Polymers', Chemical Reviews, bacterial transcription vol. 116, pp. 6743 – 6836. Sutton SK; Carter DR; Kim P; initiation complex formation', Tan O; Arndt GM; Zhang XD; Bioorganic and Medicinal Ren JM; Subbiah J; Zhang B; Baell J; Noll BD; Wang S; Chemistry, vol. 24, pp. 1171 – Ishitake K; Satoh K; Kamigaito Kumar N, 2016, 'A novel 1182. M; Qiao GG; Wong EHH; Wong compound which sensitizes WWH, 2016, 'Fullerene BRAF wild-type melanoma Tran J; Magenau A; Rodriguez peapod nanoparticles as an cells to vemurafenib in a M; Rentero C; Royo T; Enrich organic semiconductor- TRIM16-dependent manner', C; Thomas SR; Grewal T; Gaus electrode interface layer', Oncotarget, vol. 7, pp. 52166 – K, 2016, 'Activation of Chemical Communications, 52178. endothelial nitric oxide (eNOS) vol. 52, pp. 3356 – 3359. occurs through different Tan S; Cui J; Fu Q; Nam E; membrane domains in Shanmugam S; Boyer C, 2016, Ladewig K; Ren JM; Wong endothelial cells', PLoS ONE, 'Organic photocatalysts for EHH; Caruso F; Blencowe A; vol. 11. cleaner polymer synthesis', Qiao GG, 2016, Science, vol. 352, pp. 1053 – 'Photocontrolled Cargo Vittorio O, Brandl M, Cirillo G, 1054. Release from Dual Cross- Kimpton K, Hinde E, Gaus K, Linked Polymer Particles', ACS Yee E, Kumar N, Duong H, Shanmugam S; Xu J; Boyer C, Applied Materials &Interfaces, Fleming C, Haber M, Norris M, 2016, 'Light-regulated vol. 8, pp. 6219 – 6228. Boyer C, Kavallaris M. 2016, polymerization under near- 'Dextran-Catechin: An infrared/far-red irradiation Tay A; Pavesi A; Yazdi SR; Lim anticancer chemically- catalyzed by CT; Warkiani ME, 2016, modified natural compound bacteriochlorophyll a', 'Advances in microfluidics in targeting copper that Angewandte Chemie - combating infectious attenuates neuroblastoma International Edition, vol. 55, diseases', Biotechnology growth', Oncotarget, vol. 7, pp. 1036 – 1040. Advances, vol. 34, pp. 404 – pp. 47479 – 47493. 421. Sharbeen G; Youkhana J; Warkiani ME, 2016, Mawson A; Mccarroll J; Teo J; McCarroll JA; Boyer C; 'Engineering a 3D microfluidic Goldstein D; Phillips P, 2016, Youkhana J; Sagnella SM; culture platform for tumor- 'MutY-homolog modulates Duong HTT; Liu J; Sharbeen G; treating field application', pancreatic cancer cell survival Goldstein D; Davis TP, 2016, 'A Scientific Reports, vol. 6. and chemoresistance', Journal Rationally Optimized of Gastroenterology And Nanoparticle System for the Warkiani MEB; Khoo BLU; Wu Hepatology, vol. 31, pp. 60 – Delivery of RNA Interference L; Tay AKAP; Bhagat AASS; Han 60. Therapeutics into Pancreatic J; Lim CTE, 2016, 'Ultra-fast, Tumors in Vivo', label-free isolation of Sharbeen G;McCarroll J;Liu Biomacromolecules, vol. 17, circulating tumor cells from J;Youkhana J;Limbri LF;Biankin pp. 2337 – 2351. blood using spiral AV;Johns A;Kavallaris microfluidics', Nature M;Goldstein D;Phillips PA,

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protocols, vol. 11, pp. 134 – surfaces towards solution- Yeow J; Sugita OR; Boyer C, 148. based redox probes', 2016, 'Visible Light-Mediated Electrochimica Acta, vol. 213, Polymerization-Induced Self- Webb JEA; Chen K; Prasad pp. 540 – 546. Assembly in the Absence of SKK; Wojciechowski JP; Falber External Catalyst or Initiator', A; Thordarson P; Hodgkiss JM, Xu J; Shanmugam S; Fu C; ACS Macro Letters, vol. 5, pp. 2016, 'Quantifying highly Aguey-Zinsou KF; Boyer C, 558 – 564. efficient incoherent energy 2016, 'Selective transfer in perylene-based Photoactivation: From a Single Yeow J; Xu J; Boyer C, 2016, multichromophore arrays', Unit Monomer Insertion 'Facile synthesis of worm-like Physical Chemistry Chemical Reaction to Controlled micelles by visible light Physics, vol. 18, pp. 1712 – Polymer Architectures', mediated dispersion 1719. Journal of the American polymerization using Chemical Society, vol. 138, pp. photoredox catalyst', Journal Wojciechowski JP; Martin AD; 3094 – 3106. of Visualized Experiments, vol. Bhadbhade M; Webb JEA; 2016. Thordarson P, 2016, 'Halogen Yang Y; Ciampi S; Choudhury bonding influences perylene- MH; Gooding JJ, 2016, 'Light Zhang J; Yan S; Yuan D; Alici G; core twists in non-core Activated Electrochemistry: Nguyen NT; Ebrahimi Warkiani substituted perylene Light Intensity and pH M; Li W, 2016, 'Fundamentals tetraesters', CrystEngComm, Dependence on and applications of inertial vol. 18, pp. 4513 – 4517. Electrochemical Performance microfluidics: A review', Lab of Anthraquinone Derivatized on a Chip - Miniaturisation for Wong CM; Walker DB; Silicon', Journal of Physical Chemistry and Biology, vol. 16, Soeriyadi AH; Gooding JJ; Chemistry C, vol. 120, pp. 2874 pp. 10 – 34. Messerle BA, 2016, 'A versatile – 2882. method for the preparation of Zhang L; Vogel YB; Noble BB; carbon-rhodium hybrid Yang Y; Ciampi S; Zhu Y; Gonçales VR; Darwish N; Brun catalysts on graphene and Gooding JJ, 2016, 'Light- AL; Gooding JJ; Wallace GG; carbon black', Chemical Activated Electrochemistry for Coote ML; Ciampi S, 2016, Science, vol. 7, pp. 1996 – the Two-Dimensional 'TEMPO Monolayers on 2004. Interrogation of Electroactive Si(100) Electrodes: Regions on a Monolithic Electrostatic Effects by the Wong EHH; Khin MM; Surface with Dramatically Electrolyte and Semiconductor Ravikumar V; Si Z; Rice SA; Improved Spatial Resolution', Space-Charge on the Chan-Park MB, 2016, Journal of Physical Chemistry Electroactivity of a Persistent 'Modulating Antimicrobial C, vol. 120, pp. 13032 – 13038. Radical', Journal of the Activity and Mammalian Cell American Chemical Society, Biocompatibility with Yeow J; Shanmugam S; vol. 138, pp. 9611 – 9619. Glucosamine-Functionalized Corrigan N; Kuchel RP; Xu J; Star Polymers', Boyer C, 2016, 'A Zheng Y; Jiang C; Ng SH; Lu Y; Biomacromolecules, polymerization-induced self- Han F; Bach U; Gooding JJ, vol. 17, pp. 1170 – 1178. assembly approach to 2016, 'Unclonable Plasmonic nanoparticles loaded with Security Labels Achieved by Wu Y; Kashi MB; Yang Y; singlet oxygen generators', Shadow-Mask-Lithography- Gonçales VR; Ciampi S; Tilley Macromolecules, vol. 49, pp. Assisted Self-Assembly', RD; Gooding JJ, 2016, 'Light- 7277 – 7285. Advanced Materials, vol. 28, activated electrochemistry on pp. 2330 – 2336. alkyne-terminated Si(100)

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Cover Gallery

(From Left to Right, Top to Bottom)

Drug Delivery: Lanthanide-Doped 9/2016), J. Yeow, S. Shanmugam, Polymerization of a Photocleavable Upconversion Nanoparticles: N. Corrigan, R. Kuchel, J. Xu, C. Monomer Using Visible Light (Macromol. Emerging Intelligent Light-Activated Boyer (Front Cover) Rapid Commun. 11/2016), Ali Bagheri, Drug Delivery Systems (Adv. Sci. Jonathan Yeow, Hamidreza Arandiyan, 7/2016), Ali Bagheri, Hamidreza Targeted Drug Delivery: Carbon- Jiangtao Xu, Cyrille Boyer and May Lim Arandiyan, Cyrille Boyer and May Lim Quantum-Dots-Loaded Mesoporous (Back Cover) (Front Cover) Silica Nanocarriers with pH- Switchable Zwitterionic Surface and The Interaction of CORM-2 with Block Controlled Polymerization: Beyond Enzyme-Responsive Pore-Cap for Copolymers Containing Poly(4- Traditional RAFT: Alternative Targeted Imaging and Drug Delivery vinylpyridine): Macromolecular Scaffolds Activation of Thiocarbonylthio to Tumor (Adv. Health. Mater. for Carbon Monoxide Delivery in Biological Compounds for Controlled 12/2016), X. Chen, Z.N. Liu, J.J. Systems (Macromol. Rapid Commun. Polymerization (Adv. Sci. 9/2016), T. Gooding, Y.S. Zhou (Inside Front 9/2016), Diep Nguyen, Nik Nik M. Adnan, G. McKenzie, Q. Fu, M. Uchiyama, K. Cover) Susan Oliver and Cyrille Boyer (Front Satoh, J. Xu, C. Boyer, Masami Cover) Kamigaito, Greg Qiao (Frontispiece Star Polymers (Chemical Reviews, Inside Cover) 12/2016), J. M. Ren, T. G. McKenzie, A Logic Gate for External Regulation of Q. Fu, E. H. H. Wong, J. Xu, Z. An, S. Photopolymerization(Polymer Chemistry, A Polymerization-Induced Self- Shanmugam, T. P. Davis, C. Boyer, 42/2016), S. Shanmugam, J. Xu and C. Assembly Approach To Nanoparticles and G. G. Qiao (Front Cover Centre Boyer (Inside Front Cover) Loaded With Singlet Oxygen Image) Generators (Macromolecules,

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Financial Report

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Above: The mitochondria (orange) and endosomes (blue) inside a virtual breast cancer cell. Image: John McGhee

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