A Publication of The American Physiological Society Integrating the Life Sciences from Molecule to Organism THE Volume 45, Number 6 Physiologist December 2002 Integrative Physiology and Organ Systems Research and the Reorganization of Study Sections at CSR
Designing New Study Sections systems and, because of their relatively small numbers, would The Center for Scientific Review (CSR) at the National be best served by being clustered in a single IRG or study sec- Institutes of Health (NIH) is in the second phase of its reorga- tion. Sometimes this approach is reflected in the name of a new nization activities in accord with recommendations of its Panel IRG, such as Biology of Development and Aging, which includes on Scientific Boundaries for Review (PSBR). During this sec- the Aging Systems and Geriatrics Study Section. This proposed ond phase, CSR organizes Steering Committees composed of study section will review applications involving aging humans staff from CSR and the appropriate NIH Institutes to solicit or animals, particularly research on post-maturational changes, nominations of scientists from relevant communities and pro- which transcend single organ systems or disciplines and which fessional societies to participate on Study Section Boundaries may require integrated experimental, genetic or observational (SSB) Teams. Each SSB Team recommends guidelines for the approaches. Other times, clustering of cross-cutting fields study sections within one of the Integrated Review Groups occurs in a study section with a seemingly unrelated name, (IRGs) proposed in the PSBR report. such as the Xenobiotic and Nutrient Disposition and Action Study Section within the proposed Digestive Sciences IRG. Integrative Physiology and Organ Systems Research This proposed study section will review applications related to One of the hallmark conclusions of the PSBR report was that the disposition of nutrients and non-nutrient chemicals, includ- it “assigned high priority to the goal of reviewing applications ing xenobiotics such as pro-drugs and drugs, biopharmaceutical that apply to a given disease/organ system in the context of the agents, alcohol, phytochemicals/ botanicals and toxic sub- biological question being addressed because we believe that stances. Its scope may such a system results in the greatest net benefit.” This priority well extend beyond is reflected in the PSBR recommendation that CSR create four the digestive system. Inside this issue... new organ system IRGs: Pulmonary Sciences; Renal and Urological Sciences; Digestive Sciences; and Hematology. Four Opportunity for additional IRGs based on existing organ-centered IRGs were Public Comment APS Bylaw Changes proposed: Cardiovascular Sciences; Immunology; Endocrinolo- Between February p. 492 gy, Metabolism, Nutrition and Reproductive Sciences; and 2001 and November Musculoskeletal, Oral and Skin Sciences. The three neuro- 2002, CSR convened sciences IRGs will also continue in their current form. 15 of the planned 17 APS Launches Fund Raising Therefore, once the reorganization is complete, 11 of CSR’s SSB Team meetings. Campaign for the 2005 IUPS IRGs will have an organ-system orientation. The guidelines pro- Congress All the SSB Teams acknowledged the value of recognizing posed by each SSB p. 493 and clustering whole animal and human integrative physiology Team are posted on within specific study sections. Two examples of study sections CSR’s Web site APS Archive of Teaching proposed with this in mind are the Pregnancy, Neonatology and (http://www.csr.nih.gov/ Resources Lactation Study Section and the Skeletal Muscle and Exercise PSBRI/IRGComments. p. 498 Physiology Study Section. Parallel examples occur in other pro- htm) for a period of 90 posed IRGs as well, including the Clinical and Integrative days to allow comment Cardiovascular Sciences Study Section within the Cardiovas- by the scientific com- Animal Activists Indicted cular Sciences IRG, and the Pathobiology of Kidney Diseases munity. p. 508 Study Section within the Renal and Urological Sciences IRG. These are but some examples of the increased emphasis on Resolution of APS Congratulates Lasker Award organ system physiology and the importance of integrative Shared Interests Winner Willem J. Kolff physiology in peer review at CSR in the reorganization. NIH staff will con- p. 525 At the same time, the SSB Teams recognized that some fields sider the proposed of integrative physiology research cut across multiple organ (continued on page 492)
489 Published bimonthly and distributed by THE The American Physiological Society 9650 Rockville Pike Bethesda, Maryland 20814-3991 PhysiologistVolume 45 Number 6 ISSN 0031-9376 December 2002 Barbara A. Horwitz President John E. Hall Past President Contents John A.Williams President-Elect Martin Frank Integrative Physiology and Organ Experimental Biology 2003 Editor and Executive Director Systems Research and the Distinguished Lectureships 502 Councillors Reorganization of Study Tentative Schedule of Sessions 504 Kim E. Barrett, Sections at CSR 489 Featured Topics 507 Douglas C. Eaton, Joseph R. Haywood, Steven C. Hebert,Virginia M. Miller, Charles M. Tipton A Matter of Opinion Public Affairs Ignore Lies About Animal Midterm Elections Cloud Ex Officio Research Appropriations Future 508 Dale J. Benos, Robert C. Speth 491 Animal Activists Indicted 508 Mordecai P.Blaustein, Robert G. Carroll, Animal Charities Get Poor Marks for Curt Sigmund, Celia D. Sladek APS News Stewardship 509 APS Bylaw Changes 492 Publications Committee: Chairman:Dale APS Launches Fund Raising Book Reviews 511 J. Benos; Members:Penelope A.Hansen, Campaign for the 2005 IUPS Mark A. Knepper, Richard A. Murphy, Hershel Raff. Director of Publications: Congress 493 Positions Available 515 Margaret Reich. Design and Copy Editor: Joelle R. Grossnickle. Publications News From Senior Subscriptions: Distributed to members as The HighWire Library of the Sciences Physiologists 522 part of their membership. Nonmembers in and Medicine: Search and Track the USA: individuals $50.00; institutions $75.00. Nonmembers in Canada and Your Favorite Journals 494 People & Places 524 Mexico: individuals $55.00; institutions Robillard Appointed $80.00. Nonmembers elsewhere: individu- Membership as New Dean 524 als $60.00; institutions $85.00.Single copies and back issues when available, $15.00 New Regular Members 496 M. Ian Phillips Receives each; single copies and back issues of New Student Members 497 Frank Annunzio Award 524 Abstracts issues when available, $25.00. New Affiliate Members 497 APS Congratulates Lasker Award Subscribers to The Physiologist also receive Winner Willem J. Kolff 525 abstracts of the Conferences of the American Physiological Society. Education The American Physiological Society APS Archive of Teaching Announcements assumes no responsibility for the state- Resources 498 31st Annual Pediatric ments and opinions advanced by contribu- Career Opportunities in Physiology Trends Course 527 tors to The Physiologist. Symposium: “The Drug Discovery International Course on Deadline for submission of material for Process: Opportunities for Laboratory Animal Science 527 publication: Jan. 10, February issue; March Physiologists 498 Albert Lasker Medical Research 10, April issue; May 10, June issue; July 10, August issue; Sept. 10, October issue; Nov. APS/NIDDK Minority Travel Awards 528 10, December issue. Fellows Attend Conferences 499 Scientific Meetings Please notify the central office as soon as Porter Physiology Fellowships 500 possible if you change your address or and Congresses 530 Women in Physiology and telephone number. Pharmacology Symposium: Headquarters phone: 301-634-7164 APS Membership “Presentation Skills” 501 Fax: 301-634-7242 Application 531 Email: [email protected] http://www.the-aps.org Printed in the USA
490 The Physiologist A Matter of Opinion Vol. 45, No. 6, 2002 Ignore Lies About Animal Research APS Member Robert Speth is to be what might be one of the most famous site: http://www.fda.gov/opacom/back- commended for effectively demolishing experiments ever done, Sir Howard grounders/miles.html some of the animal activists’ most Florey in 1940 used eight mice to This should also serve as a timely closely-held misrepresentations about demonstrate that penicillin cured reminder of the need to properly store animal research through the use of his- streptococcal infections. This Nobel and dispose of antifreeze, because cats torical facts. Speth responded to a let- prize-winning discovery led to the use and dogs will seek out this sweet-tast- ter written by a retired science teacher of penicillin in World War II saving the ing lethal substance. that was published in The Columbian, lives of countless soldiers. For more The animal rights movement often the newspaper published in Vancouver, information, see: http://naiaonline.org/ compares the use of animals by humans WA. Speth’s response is reprinted body/articles/archives/inhumn.htm to slavery, analogizing their efforts to below. Just as Speth has responded to Regarding Charles Mayo, who the civil rights movement. But there is the misrepresentations of an animal retired from his medical practice in a stark contrast. Martin Luther King activist, physiologists should willingly 1919, he specified that earnings of the did not have to lie to gain support for step forward and meet similar chal- Mayo Clinic be used for medical edu- his movement. Dr. King did not use lenges raised in their communities. cation and research. Today part of the violence and terror to force his beliefs Only by speaking up can we expect to Mayo Clinic’s mission statement is to, on others. And, most importantly, Dr. continue to have the ability to use ani- “Conduct basic and clinical research King’s philosophy did not endanger mals in our research and teaching pro- programs to improve patient care and the very people he sought to protect. grams. By speaking up, we can chal- to benefit society.” Today it invests The animal rights movement suffers lenge the efforts of the Physicians nearly $300 million dollars into ani- from a corruption so deep as to defile Committee for Responsible Medicine mal and human research programs. the use of this term by anyone gen- and other groups to undermine public Another animal rightist distortion uinely concerned with animal welfare. support for animal health charities parroted by Steinke is that animal Worse yet, the dishonesty and igno- that support animal research asser- testing of drugs poses a danger to rance of the animal rights movement tions. Speth is to be congratulated for humans. Again, medical history threatens the health and welfare of showing the APS membership how to refutes the animal rightists. Thalid- the millions of animals whose lives respond to the challenges raised by omide caused one of the worst drug- benefit from the symbiotic relation- animal activists. induced disasters upon humanity ship we have with animals. The ani- Robert C. Speth is a professor of because it was not adequately tested mal rights movement would have us Pharmacology and Neuroscience at the on animals. Only after thousands of stop doing animal research today, College of Veterinary Medicine at deformed babies were born, was the knowing fully that this will interfere Washington State University in proper animal testing done, showing with the development of cures for Pullman and adjunct professor of that thalidomide was teratogenic (a newly emerging diseases, such as the Physiology and Pharmacology at cause of birth defects). Of note, West Nile Virus Disease, which causes Oregon Health & Science University in thalidomide was not approved for suffering and death in human and Portland. He is a past president of the morning sickness in the USA because animal populations. Society for Veterinary Medical Ethics. FDA inspector Frances Kelsey When you hear stories of animal required it to be tested on pregnant abuse from animal rightists, ask The Columbian animals. This entire story is chroni- whether they accurately represent Vancouver, WA cled in the book Suffer the Children: animal usage. There are millions of Monday, September 9, 2002 The Story of Thalidomide, by Phillip examples of humane animal use that Knightley and others. animal rightists ignore, focusing only Opinion Page Editor Delving deeper into medical history, on rare incidents of animal abuse. a major reason thalidomide was not Using their criteria we should also It is unfortunate to see a retired sci- approved for use in the USA was abolish police departments based on a ence teacher relaying the litany of lies because of a prior disaster that led to videotape showing excessive force, we and rhetoric of the animal rights the Federal Food Drug and Cosmetic should abolish democracy if a public movement (“A Local View,” 8/30/02). Act of 1938. In 1937, an antibacterial, official violates the law, and we should What the animal rights movement sulfanilamide, was dissolved in an abolish parenthood if a child is doesn’t want you to know is that antifreeze solvent (diethylene glycol) abused. Clearly such changes would advances such as water purification and given to children who subsequent- lead to anarchy and destroy our soci- and sewage treatment arose from the ly died because diethylene glycol is ety. Similarly, implementation of the animal experiments of Pasteur and toxic to the kidneys. This law led to demands of animal rightists would Koch showing that germs were the safety testing of substances in animals lead to an animal anarchy, whose vic- agents that transmitted infectious diseases. prior to their use in humans and has tims will be the very animals that ani- Mr. Steinke’s comment that our use undoubtedly saved us from countless mal rightists claim to be wanting to help. of penicillin was not based on animal similar disasters. For further informa- Robert C. Speth research, is another inaccuracy ram- tion on these and other examples of Washington State University, and pant in animal rights literature. In US drug legislation, see the FDA web- Oregon Health & Science University
491 The Physiologist Reorganization of Study Sections Vol. 45, No. 6, 2002
(continued from page 489) the Hematology SSB Team’s study sec- complete logistical arrangements. study section guidelines and the com- tion guidelines and implementation of For example, CSR is in the process of ments received from the research com- the new Hematology IRG. This was establishing rosters for the reorga- munities. CSR will consult with ex- followed in September by presentation nized Hematology study sections, and perts as necessary to clarify instances of the proposed Biology of Develop- we expect to post the rosters, along where different study sections and ment and Aging IRG, Oncological with the finalized guidelines, on our IRGs have shared interests and make Sciences IRG, and Musculoskeletal, Web site by December 2002. The first other modifications to the proposed Oral and Skin Sciences IRG. The CSR meetings of the new Hematology IRG guidelines. The Director of CSR, fol- Advisory Committee recommended study sections will occur in June 2003 lowing presentations and discussions that the study sections for these IRGs (receipt date February/March 2003). by the CSR Advisory Committee, will also be adopted with the notable addi- If you would like additional news approve the final form and substance tion of a study section on Musculo- and information about CSR’s PSBR of each study section’s guidelines. The skeletal Rehabilitation Sciences. reorganization, visit the CSR Reorga- process developed by CSR to imple- nization Activities web page at ment these recommendations is delib- Additional Year of Advance Notice http://www.csr.nih.gov/review/reor- erately cautious and iterative in order New study sections will begin meet- gact.asp. ❖ to achieve substantial community ing no sooner than one year after the Ellie Ehrenfled, Don Schneider, involvement and the best possible CSR Director approves them to ensure Michael R. Martin, Elliot Postow, review committees. that applicants are fully aware of the Anita Sostek-Miller In May 2002, the CSR Advisory nature of the study sections before Center for Scientific Review, NIH, Committee recommended adoption of they submit their applications, and to Bethesda, MD
APS News APS Bylaw Changes
During the November 2002 meeting additional Councillors shall be three Immediate Past President, and the of the APS Council, it was recom- years each and they shall not be eligi- Executive Director shall implement mended that Article IV. Officers, ble for immediate reelection except the policies of the Council. Section 1. Council and Article IV. those who have served for two years or SECTION 4. b. Nominating Com- Section 4a. Nominating Committee be less in filling interim vacancies. mittee. The Nominating Commit-tee amended to allow for the increased A quorum for conducting official shall consist of the immediate Past participation of the membership in business of the Society shall be six of President, who will serve as Society governance. The portions of the nine two-thirds of the elected Chairperson, and each member of the Article IV of the Bylaws requiring members of Council. Section Advisory Committee. The revision are published below. The APS The Chairpersons of the Chairpersons of the Joint Program Membership will have an opportunity Publications Committee, the Finance Committee and Publications Commit- to vote on the proposed changes dur- Committee, the Program Committee, tee shall serve as ex officio members. ing the APS Business Meeting sched- the Education Committee, and the The Nominating Committee shall uled for Monday, April 14, 2003 in San Executive Director are ex officio mem- select a slate from candidates nomi- Diego, California. bers of the Council without vote; the nated by the Society membership. The Chairperson of the Section Advisory slate presented for vote shall be such ARTICLE IV. Officers Committee is an ex officio member of that no more than one of the six nine SECTION 1. Council. The manage- the Council with vote. The Council Councillors shall be from a single ment of the Society shall be vested in may fill any interim vacancies in its institution and no more than two of a Council consisting of the President, membership. Council shall appoint the six nine shall have a primary affil- the President-Elect, the immediate members to all committees except the iation from the same section. The Past President, and six nine other reg- Section Advisory Committee. Nominating Committee shall make ular members. The terms of the In the interim between meetings of two nominations for the office of President and President-Elect shall be Council, an Executive Cabinet consist- President-Elect and five six nomina- one year. The terms of the six nine ing of the President, President-Elect, tions for Councillor. ❖
492 The Physiologist APS News Vol. 45, No. 6, 2002
APS Launches Fund Raising Campaign for the 2005 IUPS Congress
After a lapse of over 30 years, the financial contribution to the Congress Congress to be hosted by the US since United States will be hosting the 35th in order to provide assistance to 1968. Take a few moments now to com- International Congress of Physiologi- emerging physiologists from the US plete the donation card on page 493 cal Sciences in April 2005 in the beau- and abroad and to encourage the par- and return it with your check or cred- tiful city of San Diego. The theme of ticipation of physiologists from all it card information. All contributions this upcoming Congress is “From parts of the world. We would like to in support of the Congress are fully Genomes to Functions” and it will raise upwards of $200,000 to under- tax-deductible. Contributors will be highlight the many emerging opportu- write the participation of US and for- acknowledged and recognized in mate- nities in the physiological sciences eign physiologists, especially those rials distributed in conjunction with arising from the genomic revolution. from developing countries. the Congress. Individuals committing We intend to make this Congress a The IUPS Congress will attract $500 or more will be invited to a spe- truly outstanding international event many graduate students and postdoc- cial event held in conjunction with the by doing everything possible to pro- toral fellows seeking knowledge of the Congress. Regardless of the amount vide the best forum for the exchange of latest research findings. Many of these that you contribute, your participation knowledge in the physiological sci- physiologists do not have adequate will make a big difference as we ences among colleagues from all over funds for foreign travel to the US and launch our corporate sponsorship cam- the world. To achieve our goal of mak- need to be supported with partial trav- paign. ing this Congress the most successful el fellowships in order to attend and Please join with colleagues listed on one ever, we will need the enthusiastic present their data and learn about the previous page who have already support of the members of the yours. APS is proud to join with our made a financial commitment to the American Physiological Society. sister physiology societies to organize 2005 IUPS Congress. ❖ We invite all members of the APS to the IUPS Congress, and we ask for contribute to the success of this your financial assistance to make it an Congress through your attendance exciting and dynamic meeting. and participation. In addition, we hope Please take an active role in ensur- that all Society members will make a ing the success of the first IUPS The APS gratefully acknowledges the contributions of its members in support of the 2005 IUPS Congress. Beverly Bishop Gilbert Hageman William Mengebier Niels Henry Secher David Bohr Charles Hales Christopher Michel Mohamad Shahid Salles Felix Bronner John Hall Florence Millar Jose Pedro Segundo Howard Burchell William Halpern Peter Morrison Walter Shelley Shu Chien Lisa Ann Hernandez Kenneth Nagy Curt Sigmund Erminio Costa Alan Hofmann L. Gabriel Navar Zohreh Sirous Allen Cowley Andrew Huxley Yasuhiro Nishida Ralph Sonnenschein William Cupples Akio Inui Robert Nye Jos Spaan William Dantzler Paul Johnson Charles Paganelli Harvey Sparks Gerald DiBona Chang-Ju Kim John Pappenheimer Norman Staub Virginia Donaldson Tokihisa Kimura Charles Park Bernard Steinetz Esther Dupont- Leonard Kirschner Johnny Porter Lou Ann Stephenson Versteegden Ulla Kopp Helen Ranney Heinrich Taegtmeyer Alfred Fishman Tomoyuki Kuwaki Ursula Ravens Aubrey Taylor G. Edgar Folk David Lawson Eugene Renkin Helen Tepperman Martin Frank Thomas Lesh David Robertshaw Peter Tonellato Yuan-Cheng Fung Richard Levine Juan Sanchez-Esteban Daniel Tosteson William Ganong Benjamin Libet Wilbur Sawyer John Urquhart Rene Girerd Ira Lichton James Schafer Silvio Weidmann Alfred Goldberg Christopher Marino Bodil Schmidt-Nielsen John West Barbara Goodman Charles McCormack Robert Schrier John Widdicombe Richard Grindeland Nansie McHugh Stanley Schultz Richard Wyeth Francis Haddy Ivan McMurtry Gordon Searle
493 The Physiologist APS News Vol. 45, No. 6, 2002
Publications
The HighWire Library of the Sciences and Medicine: Search and Track your Favorite Journals
In the February issue of The HWLSM’s designers observed that home page identifies what the most Physiologist, we introduced the new labs typically monitor a few dozen current content is in each of your “portal” site from Stanford’s HighWire journals, and that individuals in labs favorite journals, and lists your Press: the HighWire Library of the each take responsibility for knowing favorite journals by most recent con- Sciences and Medicine (HWLSM) what is new and important in just a tent date. It also provides quick links (http://highwire.stanford.edu). In handful among those journals. So the to the newest content, the journal August we began a series of short arti- system has features to help you take a home page, the current-issue Table of cles highlighting tools or features of narrow focus when you want to search Contents page, and the search page for this new site, starting with the ability several journals—but only your each of your favorite journals. It also to quickly see which articles are freely favorites —and to help you keep track shows a tiny version of the new-issue available to you. This month we con- of new content in these favorite jour- cover for each journal. You will be able tinue the series with a look at how you nals. to see the listing of My Favorite can have the system keep track of Search Scope: You can click a button Journals in the right column of the your favorite journals, including the on any search form and instantly HWLSM home page. Later on, the por- family of APS journals. restrict the scope of a search to include tal will have a new alerting feature The new HWLSM allows you to only your favorite journals. Note the allowing you to restrict your instantly search abstracts from all radio button labeled “My Favorite CiteTrack alerts to include only your 4,500 journals in Medline, plus the Journals” in the center column of the favorite journals. full-text of over 325 journals hosted by HWLSM home page shown (Figure 1) Getting Started Stanford’s HighWire Press. For the on page 495. To put these Favorite Journal fea- full-text journals, a registered user Search-result Highlighting: In any tures to work for you, you must tell the (registration is free, and takes less search result display—whether limit- portal which journals are your than a minute) can tell the portal ed to favorite journals or not—the por- favorites. which of the HWLSM-hosted titles are tal will highlight citations from your Step 1: If you haven’t already, you your “favorite journals.” Then, some favorite journals by showing the jour- will need to Register with the portal special capabilities are available for nal cover over a purple bar. (this takes only a minute), by clicking those designated favorites. Monitor new Content: The HighWire on the Register link on the HighWire
494 The Physiologist Publications Vol. 45, No. 6, 2002
home page. If you have already regis- are returned to the portal home page, August: “Find Full-Text Articles, tered, you will need to sign-in. and the Favorite Journal features will Free and Fast” Step 2: After registering or signing be active, with a new [edit] link at the October: “Tailoring Search Results in, first time users will see a “What is bottom of your selected journals. You in the HighWire Library of the this?” link under the heading My can easily change your Favorite Sciences and Medicine: ‘Have it Your Favorite Journals. Click on “What is Journal list by clicking on [edit]. Way’” this?” to be taken to a short summary In the next issue we’ll look at how December: “The HighWire Library of the My Favorite Journals feature, you can instantly retrieve an article — of the Sciences and Medicine: Search including the link “Create/Modify ‘My and often its full-text—just by typing and Track Your Favorite Journals Favorite Journals’ preferences.” its year, volume and first page citation Easily” Step 3: Click on the “Create/Modify information into the search form. Coming next: “‘Citation Search’: ‘My Favorite Journals’ preferences” Here is the list of what we’ve cov- Type Just Three Numbers to Get Any link and mark which journals are your ered in this series of short tips: Article.” ❖ favorites. After making your selections February: “Creating a Better and clicking the submit button, you Mousetrap!”
Figure 1.
495 The Physiologist Membership Vol. 45, No. 6, 2002
New Regular Members *Transferred from Student Membership
Michael F. Allard Monty Armando Escabi David Allan Kregenow Univ. of British Columbia, Canada Univ. of Connecticut Univ. of Washington Bradley Tram Andresen* Martin Feelisch Atsukazu Kuwahara NIH, NIDCR, MD Louisiana State Univ. Univ. of Shizuoka, Japan Gerard Apodaca Stefano Fiorucci Gerald Patrick Lambert* Univ. of Pittsburgh, PA Univ. of Perugia, Italy Creighton Univ., NE Shayn E. Armstrong Melissa Ann Fleegal* Tsung-Ming Lee Albany Medical College, NY Univ. of Florida National Taiwan Univ. Hosp., Taiwan Shinji Asano Larry Fliegel Jianping Li Toyama Med. & Pharmac. Univ., Japan Univ. of Alberta, Canada Michigan State Univ. Sandra R. Bates Markus Frederich Han-Chung Lien Univ. of Pennsylvania Brigham & Women’s Hosp., MA Taichung Veterns Gen. Hosp., Taiwan Suzanne Barbara Bausch Sebastian Frische Douglas William Losordo Uniformed Services Univ.Health Sci., MD Univ. of Aarhus, Denmark St. Elizabeth Med. Ctr., KY Lori A. Birder Paul Douglas Gamlin Malcolm A. Lyons Univ. of Pittsburgh, PA Univ. of Alabama, Birmingham The Jackson Laboratory, Maine Russell P. Bowler Francis John Golder* Douglas L. Mann National Jewish Med. and Res. Ctr., CO Univ. of Wisconsin Baylor College of Medicine, TX Rachell E. Booth David L. Goldstein Sheerin Mathur Univ. of Texas HSC, San Antonio Wright State Univ., OH Pfizer Inc., CT Gregory Allen Brown* Robert C. Gorman Nilanjana Maulik Georgia Southern Univ. Univ. of Pennsylvania Univ. of Connecticut Marybeth Brown Beth Ann Habecker Bidyut Kumar Medda Univ. of Missouri, Columbia Oregon Health & Science Univ. Medical College of Wisconsin Abel Bult-Ito Craig M. Hauck* Daphne Mekus Univ. of Alaska, Fairbanks Stanford Univ., CA Eramus Univ. Rotterdam, Netherlands Paula Jane Busse Gerlinda E. Hermann Evangelos D. Michelakis Mount Sinai School of Medicine Pennington Biomedical Res. Ctr., LA Univ. of Alberta, Canada Nuala Mary Byrne Geoffrey D. Holman Michael L. Oshinsky Queensland Univ. Technol., Australia Univ. of Bath, United Kingdom Thomas Jefferson Univ., PA Mairead A. Carroll Daniel P. Holschneider D. Ann Pabst New York Medical College Univ. of Southern California Univ. of North Carolina, Wilmington Louis G. Chicoine Michal Horowitz Ying-Jie Peng Univ. of New Mexico Hebrew Univ., Israel Case Western Reserve Univ., OH David J. Christini Sheau Yu Teddy Hsu Danny Petrasek Cornell Univ., NY Stanford Univ., CA California Insitute of Technology William A. Coetzee Chou-Long Huang Charles S. Redwood New York Univ. Univ. of Texas Southwestern Med. Ctr. Univ. of Oxford, UK David Michael Conway Bozena Jemiolo Antonio Rendas Southeastern Oklahoma State Univ. Ball State Univ., IN Univ. Nova De Lisboa, Portugal Leslie Anne Cornick* Steven P. Jones Christian K. Roberts* Univ. of Alaska, Fairbanks Johns Hopkins Univ., MD Univ. of California, LA Jacqueline M. Crisman Afksendiyos Kalangos Richard C. Rogers Penn State Univ., College of Medicine Univ. Hospital of Geneva, Switzerland Pennington Biomedical Res. Ctr., LA Reinaldo Victor DiPolo Roma Kalra Satinder Singh Sarang Ctro. De Bidfisica Bioquimica, Venezuela Lovelace Respiratory Res. Inst., NM Brigham and Women’s Hosp., MA Dragan Milan Djuric Paul J. Kammermeier Petra Maria Schmitt Univ. Sch. of Med., Belgrade, Yugoslavia Northwestern Ohio Univ. Univ. of California, Davis Raed A. Dweik Cynthia J.M. Kane Weihua Shen Cleveland Clinic Foundation, OH Univ. of Arkansas Indiana Univ. Scott Earley* Daniel MacRae Keenan Yukitaka Shizukuda Univ. of New Mexico Univ. of Virginia NHLBI, NIH, MD
496 The Physiologist Membership Vol. 45, No. 6, 2002
Scott Alan Smith* Carlos Marcelo Telleria David D. Woo Univ. of Texas Southwestern Med. Ctr. Univ. of South Dakota Univ. of California, Los Angeles Peter Michael Snyder Bernard Thebaud Wenhui Xiong Univ. of Iowa Univ. of Alberta, Canada Yale Univ., CT Dong Hwan Sohn James N. Topper Xiaojzang Xu Wonkwang Univ., South Korea Millennium Pharmaceuticals Inc., CA US Army Inst. Environ. Med., ME Alexandre Alarcoll Steiner* Michelle Zavitz Tucker* Saul Yedgar St. Joseph’s Hosp. & Med. Ctr., AZ Bio-Rad Laboratories, CA Hebrew Univ., Israel Nathaniel Joao Szewczyk* Robert Stephen Vick Bin-Xian Zhang NASA Ames Res. Ctr., CA Elon Univ., NC Audie L. Murphy VA Hospital, TX Koji Takeuchi Niels Vrang* Shiping Zhang Kyoto Pharmaceutical Univ., Japan Rheoscience, Denmark Univ. of Cincinnati, OH Shigeo Taniguchi Bruce Allan Waldrop* Wensheng Zhang Tokyo Univ., Japan Shenandoah Univ., VA Tufts Univ., MA
New Student Members
Vijay Amarendran Melissa Lynn Holt Melinda Gabriela Saban Univ. of Wyoming Florida Atlantic Univ. Univ. de Buenos Aires Jon C. Ashmead Patrick C.H. Hsieh Javier Sabarros Univ. of Calgary, Canada Univ. of Washington Univ. de Buenos Aires Raul Cesar Camacho Kristen Leigh Hutchins Rasnapreet Sabharwal Vanderbilt Univ., TN Univ. of Missouri, Columbia Univ. of Birmingham, England Jennifer Diane Cannon Christina Marie Levensky Sethu Raman Saminathan Medical College of Georgia Kent State Univ., OH Univ. of Madras-Taramani, India Erica Arden Dale Carewe Marcy K. Lowenstein Eric Matthew Sandberg San Diego State Univ., CA Florida International Univ. Univ. of Florida College of Med. Mona Lynne Chappellaz Scott M. MacDonnell Sarah Louise Sayner Univ. of Calgary, Canada Temple Univ. Univ. of South Alabama Melanie Cree Patricia M. Maldonado Sandra C. Seufert Univ. of Texas Medical Branch Univ. of Puerto Rico Florida Atlantic Univ. Allison Nicole Dawson Jeremy Louis Mello Danielle R. Shemanski Univ. of California, Davis Florida Atlantic Univ. Univ. of California, Los Angeles Chantel Teresa Debert Christopher L. Mendias La’Tonia M. Stiner Univ. of Calgary, Canada Univ. of Arizona Wright State Univ., OH Valerie Karelle Duggan Michelle Mielke Amanda Mary Szucsik Florida Atlantic Univ. Florida Atlantic Univ. Univ. of California, Irvine Anita E. Fofie Jennifer Elaine Naugle Tiffany Ann Wallace Univ. of Calgary, Canada Kent State Univ, OH Univ. of Florida College of Med. Olga Georgiadou James Scott Pattison Yifan Yang Univ. of Athens, Greece Univ. of Missouri Ball State Univ., IN Taren Grass Octavia M. Peck Terese Marie Zidon Univ. of Montana Med. Univ. of South Carolina Univ. of Missouri Emile Mary Gray Tracey Anne Phillips Tomasz B. Zawislan Univ. of California, Irvine Univ. of Florida Florida Atlantic Univ. Lewis George Halsey Julie Annette Reynolds Univ. of Birmingham, AL Louisiana State Univ. Francis Haman Ivan Rubio-Gayosso Univ. of Ottawa, Canada Univ.Autonoma San Luis Potosi, Mexico
New Affiliate Members
Jianxin Chen Michael S Graham Harvard Univ. Sch. of Public Health, MA St. Lawrence Univ., NY
497 The Physiologist Education Vol. 45, No. 6, 2002
APS Archive of Teaching Resources
The APS Archive of Teaching web sites you have discovered that Convective/Osmotic Water Move- Resources (http://www.apsarchive.org) have valuable information for your ment (simulation) continues to grow with the recruit- teaching; Water-Electrolyte Disturbances (sim- ment of a variety of new learning teaching tools/materials that you ulation) objects from educators all over the are developing that would benefit Michael Davis country. To date, about 135 items have from feedback from your colleagues; Pulmonary Jeopardy (review game) been received for the Archive from anything educational related to Steven DiCarlo various sources. physiology, pathophysiology, or clinical Physiology of the Kidneys, Body However, more material is still physiology. Fluids and Acid-Base Balance (revised needed. Please consider submitting By submitting learning objects that PowerPoint) material that you have developed to you have developed, you can help your John Dietz use to make your teaching more effec- colleagues in their efforts to find the Acid-base Tutorial (simulation) tive. These can be: best tools for introducing their stu- Alan Grogono lecture or course outlines or dents to the exciting discipline of Human Physiology 801: Renal PowerPoint slides from a lecture that is physiology. Section (course outline, lectures, prac- particularly effective with your students; Here are some new items in the tice exams) problems or cases you’ve written for Archive. Take a moment and check out Human Physiology 801: Cardiovas- your classes; those that are most relevant to your cular Section (course outline, lectures, diagram(s) that you’ve created to teaching. Don’t forget that you can practice exams) illustrate a specific pathway or pro- comment on any of these items Robert Gore cess that seems to clarify it for your through the comment section attached Simulations in Physiology: The students; to each item. Respiratory System (simulation) simulations or videos you have Harold Modell ❖ developed;
Career Opportunities in Physiology Symposium “The Drug Discovery Process: Opportunities for Physiologists”
Experimental Biology 2003 discovery, and demonstrate how aca- drugs that have efficacy in a disease Sunday, April 13, 5:30-7:30 PM demic collaboration with industry model, to preclinical safety, pharma- Room 11A Convention Center leads to new drug discoveries. The cokinetics, pharmacodynamics, to vari- program will lead the audience ous phases of clinical trials all the way This symposium will expose young through the drug discovery process to getting the new drug on the market. physiologists to new career opportuni- from discovery of the initial drug tar- Each speaker will highlight the unique ties, educate others about the impor- get, to the role of the academic scien- career opportunities at all levels for tant work of the physiologist in drug tist, to the development of candidate trained physiologists. ❖
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APS/NIDDK Minority Travel Fellows Attend 2002 Conferences in San Francisco and San Diego The APS regularly awards Travel ence the many aspects of each confer- Comparative Physiology: Evolution, Fellowships for underrepresented ence. Integration and Applied” were: Rudy minority scientists and students to The travel awards are open to grad- M. Ortiz, University of California- attend APS scientific meetings with uate students, postdoctoral students, Santa Cruz; LaTonia Marie Stiner, funds provided by the National and advanced undergraduate stu- Wright State University; Vanessa I. Institute of Diabetes and Digestive dents from minority groups underrep- Toney, Brown University; Vallie M. and Kidney Diseases (NIDDK). The resented in science (i.e., African Holloway, Loyola University Medical Fellowships provide funds for trans- Americans, Hispanics, Native Ameri- Center; Luciana Oliveira Santos, portation, meals, and lodging for trav- cans, and Pacific Islanders). Students University of Utah; Elizabeth S. el to a meeting location, as well as must be US citizens or permanent res- Quintana, New Mexico State complimentary meeting registration. idents. The specific intent of this University; Ruth A. Washington, Three Fellows attended the APS award is to increase participation of Stillman College; Lee A. Aggison, Conference “Physiological Genomics of pre- and postdoctoral minority stu- Jr., Stillman College; Rafael Cardiovascular Disease: From dents in the physiological sciences. For Alejandro Leos, New Mexico State Technology to Physiology,” in San more information, contact Brooke University; Thomas F. Gallegos, Francisco, CA, February 20-23, 2002. Bruthers in the APS Education Office New Mexico State University; and Eleven Fellows attended the APS at 301-634-7132 or bbruthers@the- Marcy K. Lowenstein, Florida Conference “The Power of aps.org, or visit http://www.the- International University. APS Comparative Physiology: Evolution, aps.org/education/minority_prog/inde Mentors included: Rudy M. Ortiz, Integration and Applied,” in San x.htm on the APS website. University of California, Santa Cruz; Diego, CA, August 24-28, 2002. Fellows at “Physiological Genomics Jeffrey Hazel, Arizona State Fellows in the NIDDK Minority of Cardiovascular Disease: From University; William Milsom, Travel program not only received Technology to Physiology” were: University of British Columbia; financial support to attend these Carmen Padro, University of Puerto Martin Frank, Executive Director, meetings, but were also provided pro- Rico Medical Science; Marcos APS; Stephen Secor, University of fessional guidance through pairings Echegaray, University of Puerto Rico Alabama; Marvin Bernstein, New with APS members who served as at Cayey; and Miguel Rivera, Mexico State University; Siribhinya mentors to the Fellows for the dura- University of Puerto Rico School of Benyajati, University of Oklahoma tion of the conference. Thanks to the Medicine. The APS Mentor at the con- Health Science Center; and Jeffrey time and expertise offered by mentor ference was Curt D. Sigmund, Graham, University of California, volunteers, Fellows were able to maxi- University of Iowa. San Diego. ❖ mize their time and more fully experi- Fellows who attended “The Power of
APS Education Committee “Refresher Course on Muscle Physiology: From Cellular to Integrative” And “Laboratory Session on Human Exercise”
“Refresher Course on Muscle Muscle physiology is an important smooth, skeletal, and cardiac muscle, Physiology: From Cellular to component in the teaching of a num- followed by an integration of these sys- Integrative” ber of organ systems and of the inte- tems in the context of the physiological Experimental Biology 2003 gration of these systems in response to response to exercise. Friday, April 11, 8:00 AM -12:00 PM environmental stresses. Purposeful The afternoon workshop will include Room 8, Convention Center movement, as well as normal cardio- hands-on demonstrations by commer- vascular, respiratory, and gastroin- cial companies. ❖ “Laboratory Session on Human testinal function all depend on intact, Exercise” healthy muscles. This unique refresh- Experimental Biology 2003 er course will present up-to-date con- Friday, April 11, 1:00 - 5:00 PM cepts in muscle physiology. The mate- Convention Center rial in the morning session will cover
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It’s time to talk to middle and high school teachers about...
eachers Frontiers in Physiology Professional Development Fellowship for T Application Deadline is January 10, 2003 Teachers are seeking research hosts for Summer 2003. Contact them soon—the deadline is just around the corner. Contact the Education Office with questions. http://www.the-aps.org/education/frontiers/index.htm
American Physiological Society 9650 Rockville Pike, Bethesda, MD 20854-3991 T: 301-634-7132 F: 301-634-7098 E: [email protected]
Program Announcement Porter Physiology Fellowships for Minorities Closing Date for New Applications: January 15, 2003 Announcement of Awards: May 20, 2003
Annual Stipend: $18,000 Duration of Fellowship: 1 year with possibility of 2nd year of support
The Porter Physiology Fellowships for FOR AN APPLICATION Minorities are open to underrepresented CONTACT: ethnic minority applicants (African Americans, The American Physiological Society Hispanics, Native Americans, Native Alaskans, Education Office or Pacific Islanders) who are citizens or 9650 Rockville Pike permanent residents of the United States or Bethesda, MD 20814-3991 its territories. Applicants must have been (301) 634-7132 fax (301) 634-7098 accepted into or currently be enrolled in a [email protected] graduate program pursuing an advanced http://www.the-aps.org/education/ degree in the physiological sciences. minority_prog/porterfell.htm
Sponsored by: APS Porter Physiology Development Committee
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Encouraging Undergraduate Students in Biomedical Research Careers Undergraduate Summer Research Fellowship Women in Physiology and Pharmacology www.the-aps.org/education/ugsrf/index.html Symposium For APS Members and “Presentation Skills” Undergraduate Students:
Students will: Experimental Biology 2003 Experience 10 weeks of Monday, April 14, 8:00-10:00 AM research during the Room 11A Convention Center
summer in the lab of an This symposium will address the various types of established APS- presentation skills that a physiologist will need to have member investigator; to prosper in his/her career. These include: Interview skills Attend an APS meeting; Oral presentation skills Present an abstract at an Poster presentation skills APS Conference. Presenting oneself at national meetings Facing the public Preparing/giving a lecture Deadline for Applications Using visual aids/multimedia effectively Presentations will be made by speakers, which will photo source: photodisc.com February 3, 2003 be followed by small group discussions of specific topics. The American Physiological Society, Education Office 9650 Rockville Pike, Bethesda, MD 20814-3991 301-634-7132, Fax: 301-634-7098 Email: [email protected] http://www.the-aps.org/education.htm
The American Physiological Society Medical Physiology Curriculum Objectives http://www.the-aps.org/education/MedPhysObj/medcor.htm Download in HTML or PDF format A systematic presentation of core physiological concepts ♦ Cardiovascular ♦ Muscle focused primarily on normal body function. The Objectives ♦ Cell and General ♦ Neurophysiology provide guidelines for the breadth and depth of knowledge ♦ Endocrinology and ♦ Respiratory in the physiological principle and concepts in understand- Metabolism ♦ Renal, Fluid Balance, ing mechanisms of disease and body defenses in pharma- ♦ Gastrointestinal and Acid-Base cology, pathology, pathophysiology, and medicine. ♦ Integration and Exercise
NOW AVAILABLE IN PRINT FORM; UP TO 15 COPIES FREE PER DEPARTMENT.
The Medical Physiology Curriculum Objectives is a APS Education Office joint project of The American Physiological Society and the 9650 Rockville Pike, Bethesda, MD 20814-3991 Association of Chairs of Departments of Physiology. Phone: 301-634-7132; Fax: 301-634-7098: Email: [email protected]; http://www.the-aps.org/education.htm
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PHYSIOLOGY IN PERSPECTIVE: HENRY PICKERING BOWDITCH THE WALTER B. CANNON AWARD LECTURE AWARD LECTURE (SUPPORTED BY THE GRASS FOUNDATION) Paul Kubes Shu Chien University of Calgary University of California, San Diego “Molecular Mechanisms Underlying Leukocyte “Modulation of Gene Expression and Recruitment in the Cellular Functions by Microcirculation” Mechanical Forces: Wisdom of the Body” SATURDAY,APRIL 12, 5:45 PM
FRIDAY,APRIL 11, 5:45 PM
Distinguished Lectureships
CARL LUDWIG CLAUDE BERNARD DISTINGUISHED LECTURESHIP DISTINGUISHED LECTURESHIP OF THE NEURAL CONTROL AND OF THE TEACHING OF AUTONOMIC REGULATION PHYSIOLOGY SECTION SECTION John D. Bransford John Coote, Vanderbilt University University of Birmingham, UK “When Knowledge of How “The Significance for People Learn Meets Circulatory Control of the Classrooms and Technology: Paraventricular Nucleus” Issues and Opportunities”
SATURDAY,APRIL 12, 10:30 AM SATURDAY,APRIL 12, 2:00 PM
JULIUS H. COMROE,JR. CARL W. G OTTSCHALK DISTINGUISHED LECTURESHIP DISTINGUISHED LECTURESHIP OF THE RESPIRATION SECTION OF THE RENAL SECTION
John B. West William J. Arendshorst University of California, University of North Carolina San Diego “Reactivity of the Renal “Thoughts on the Blood-Gas Microcirculation in Genetic Barrier” Hypertension”
SATURDAY,APRIL 12, 2:00 PM SATURDAY,APRIL 12, 3:15 PM
AUGUST KROGH ROBERT M. BERNE ISTINGUISHED ECTURESHIP D L DISTINGUISHED LECTURESHIP OF THE COMPARATIVE OF THE CARDIOVASCULAR PHYSIOLOGY SECTION SECTION Peter Scheid Ruhr University, Eric O. Feigl Bochum, Germany University of Washington
“The Goose of the Himalaya “Berne’s Adenosine and Central Chemosensitivity; Hypothesis of Coronary New Ideas From an Blood Flow Control” Old Problem” SUNDAY,APRIL 13, 10:30 AM SUNDAY,APRIL 13, 9:00 AM
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HORACE W. D AVENPORT EDWARD F. A DOLPH DISTINGUISHED LECTURESHIP DISTINGUISHED LECTURESHIP OF THE GASTROINTESTINAL OF THE ENVIRONMENTAL AND EXERCISE PHYSIOLOGY SECTION SECTION
Jeffrey I. Gordon, Jere Mitchell Washington University University of Texas, Southwestern Medical School “Living With Microbes: “Neural Circulatory Control An Inside View” During Exercise: Insights From Animal and Human SUNDAY,APRIL 13, 2:00 PM Studies”
MONDAY,APRIL 14, 8:00 AM
ERNEST H. STARLING JOSEPH ERLANGER DISTINGUISHED LECTURESHIP DISTINGUISHED LECTURESHIP OF THE WATER AND ELECTROLYTE HOMEOSTASIS OF THE CENTRAL NERVOUS SECTION SYSTEM SECTION
Friedrich C. Luft Fred H. (Rusty) Gage Humboldt University, Berlin The Salk Institute
“The Role of Genetic Models “Regulation and Function of in Elucidating Adult Neurogenesis” Cardiovascular Reflex Regulation” MONDAY,APRIL 14, 2:00 PM
MONDAY,APRIL 14, 10:50 AM
SOLOMON A. BERSON HUGH DAVSON DISTINGUISHED LECTURESHIP DISTINGUISHED LECTURESHIP OF THE ENDOCRINOLOGY AND OF THE CELL AND MOLECULAR METABOLISM SECTION PHYSIOLOGY SECTION
Christopher B. Newgard Roger Y. Tsien Duke University University of California, San Diego “Mechanisms of Fuel- Stimulated Insulin “Unlocking Cell Secrets With Secretion and How They Light Beams and Molecular Fail in Diabetes” Spies”
MONDAY,APRIL 14, 3:15 PM MONDAY,APRIL 14, 3:15 PM Fifth Annual Walter C. Randall Lecture in Biomedical Ethics Linda MacDonald Glenn, LL.M. Senior Fellow, Institute for Ethics American Medical Association
Tuesday, April 14, 2003 2:00 PM Room 9, Convention Center
503 The Physiologist Experimental Biology 2003 Vol. 45, No. 6, 2002 Tentative Schedule of Sessions Friday, April 11, Morning Session Gap Junctional Hemichannels: Physiology and Pathophysiology Refresher Course: Muscle Physiology: Cell & Molecular Physiology Section From Cellular to Integrative L. Reuss and L. Ebihara Education Committee G. Ordway and R. Hester Functional Genomics and Proteomics of Hypoxia Hypoxia Group N. Prabhakar and J. Klein Friday, April 11, Afternoon Sessions Physiology InFocus—Physiological Implications of Frontiers of Intravital Microscopy: Oxidative and Nitrosative Stress: Emerging Concepts Crossroads of Physiology and Pathology in Oxidative and Nitrosative Signaling Workshop J. Beckman and Y. Jannsen-Heinenger M.S. Goligorsky Molecular Regulation of Nitric Oxide Synthase Activity “IACUC 101” for Scientists Renal Section Public Affairs P. Ortiz and J. Sullivan J. Stallone The Teacher as an Educational Researcher Making Science News Teaching of Physiology Section Communications Committee J. Michael and D. Silverthorn A. Gwosdow
MCS President’s Symposium: Saturday, April 12, Afternoon Sessions Mechanisms of Microvascular Dysfunction in Diabetes The Microcirculatory Society MCS Landis Award Lecture P.F. McDonagh The Microcirculatory Society TBA Methods to Detect Oxidative and Nitrosative Stress Workshop Recent Advances in the Study of Hexose Transport Proteins M.B. Grisham and J. Granger Gastrointestinal Section and American Society for Nutritional Sciences R. Ferraris Saturday, April 12, Morning Sessions Mechanisms for Contractile Depression in Heart Failure Genomics of Angiogenesis and the Microcirculation Muscle Biology Group Physiological Genomics Group R.A. Walsh and K.R. Chien J.B. Hoying Oxidative Stress, Antioxidant Supplementation Physiology InFocus—Physiological Implications of and Diabetes Oxidative and Nitrosative Stress: General Overview American Federation for Medical Research and Disease Relevance E.C. Opara M. Grisham and M. Traber Plasticity and Behavior Modulation of Respiratory Motoneurons Association of Latin American Physiological Societies From Molecules to Behavior R. Guevara Guzmán Respiration Section A.J. Berger MCS Young Investigator’s Symposium The Microcirculatory Society Peroxisome Proliferator-Activiated Receptors (PPARs) J.C. Frisbee and D.W. Stepp Cross Sectional Y. Guan and C. Sigmund NHLBI Program for Genomic Applications: Background for Physiologists Novel Ca2+ Signaling Mechanisms in Vascular Myocytes: Physiological Genomics Group, National Institutes of Cyclic ADP-Ribose, Ryanodine Receptors and Health, and American Society for Biochemistry and Ca2+-induced Ca2+ Release Molecular Biology Cardiovascular Section A. Kwitek-Black P-L. Li and C. Van Breeman
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Sunday, April 13, Morning Sessions The Chronobiological Environment of Mammals Environmental & Exercise Physiology Section Flow/Stretch-Regulated Membrane R. Refinetti and Ion Transport in Epithelia Epithelial Transport Group Mitochondria Regulation of Cell Function L. Satlin and G. Apodaca Cross Sectional J. Bhattacharya Understanding and Applying Critical Translational Assays Liaison with Industry Committee Redox Signaling of Angiogenic Response in the Heart G. Reinhart and C. Montrose-Rafizadeh Cardiovascular Section D.K. Das and N. Maulik Neurogenic Hypertension Neural Control & Autonomic Regulation Section Non-arterial Circulations: The Dark Side A. Sved of Cardiovascular Biology Comparative Section Physiology InFocus—Physiological Implications S. Warburton and T. Wang of Oxidative and Nitrosative Stress: Cardiovascular Consequences of Oxidative/ Nitrosative Stress Physiology in Medicine: J. Elserich and K. Griendling Renal and Cardiovascular Physiology Translatonal Research Group The Renin-Angiotensin System and Development J.E. Hall and D.J. Benos Endocrinology & Metabolism Section J.C. Rose and C. Rosenfeld Redox Regulation of Renal Function and Arterial Pressure Water & Electrolyte Homeostasis Section Magnetic Resonance: Unique Non-invasive Insights R.D. Manning, Jr. and A-P. Zou Into the Physiology of Exercise Environmental & Exercise Physiology Section Building Better Bone: Sex Genes and Drugs R. Richardson and M. Olfert American Federation for Medical Research and American Society for Bone and Mineral Research Thin Filament Regulation of Muscle Contraction T.L. Clemens Muscle Biology Group J-P. Jin Understanding Protein Unfolded States: Implications for Folding, Function, Evolution and Disease Physiology InFocus—Physiological Implications Biomedical Engineering Society of Oxidative and Nitrosative Stress: Pulmonary and R.V. Pappu Endocrine Consequences of Oxidative/Nitrosative Stress B. Halliwell and J. Mannick Careers in Physiology Symposium: The Drug Discovery Process: Opportunities Peer Review and Publication in APS Journals for Physiologists Publications Committee Careers in Physiology Committee D. Benos J.H. “Wick” Johnson and J.M. Norton
Role of the Transcription Factor, TonEBP/NFAT5 Renal Section Monday, April 14, Morning Sessions M. Burg and J. Handler Neuron-Glial Interactions in Nervous System Function The Pons: A Critical Component in Respiratory Control Cross Sectional Respiration Section B. Ransom and J. Dietmer D.R. McCrimmon The Function and Regulation of Mitochondrially Sunday, April 13, Afternoon Sessions Produced Nitric Oxide in Cardiomyocytes Cardiovascular Section A.J. Kanai and J. Peterson Glucagon-like Peptide 2: A Nutrient-responsive Intestinal Growth Factor-biological Function Caveolin Regulation of Endothelial Function and Therapeutic Application in Disease Respiration Section American Society for Nutrition Sciences and R.D. Minshall, A. B. Malik Gastrointestinal Section D. Burrin and K. Tappenden
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Presentation Skills Tuesday, April 15, Morning Sessions APS Women in Physiology Committee and ASPET Women in Pharmacology Committee Functional Proteomics: Applications to the C.M. Liedtke, S. Benyajati and J. Lakoski Cardiovascular System Cardiovascular Section Lineage Specific Programming of Stem Cells Into Tissues P. Ping Cross Sectional Q. Al-Aqwati Epithelial-neuronal Interactions Underlying Bladder Gene-Regulation and Sensory Function Caveolar Domains in Cell Signaling Physiological Genomics Group Cell & Molecular Physiology Section L.A. Birder P.A. Insel Regulation of Ion Channel Structure and Function Life to Death Decisions and the Fate of Apoptotic Cells by Reactive Oxygen Nitrogen Intermediates Endocrinology & Metabolism Section Respiration Section J.A. Cidlowski S. Matalon and D.C. Eaton
The Identities of Estrogen Receptors Mediating AT-1 and AT-2 Receptors: Angatonists in Cellular Action? Nongenomic Effects Cross Sectional Physiological Genomics Group C. Sumners and M. Hay C.S. Watson and P.W. Shaul Subcellular Organization of Second Messenger Signaling in Cells of the Cardiovascular System Monday, April 14, Afternoon Sessions Cardiovascular Section R. Lynch Remodeling of the Brain Underlies the Success of Behavioral Therapies for Motor Dysfunction New Roles for Ammonia in Renal Ion Transport Central Nervous System Section Renal Section E. Taub I.D. Weiner and L.L. Hamm
The History and Physiology of High Altitude Everything Old is New Again: Thyroid Hormone Decompression Sickness and the Failing Heart History of Physiology Group American Federation for Medical Research S. Schneider and M.R. Powell C.S. Long
The Biology of Differentiated Thyroid Cancer: Transgenic Models of Heart Failure Therapeutics A Bench to Bedside Review American Society for Pharmacology and Experimental American Federation for Medical Research Therapeutics and Cardiovascular Section B.R. Haugen J.D. Port
Career Planning for Experimental Biology, Biomedical and Physician Scientists Society for Experimental Biology and Medicine K.L. Barker
Moving? If you have moved or changed your phone, fax, can also be changed by visiting the Members or email address, please notify the APS Only portion of the APS website at Membership Office at 301-530-7171 or fax to http://www.the-aps.org. 301-571-8313. Your membership information
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Section-Sponsored Featured Topics
Muscle Fatigue Structure and Regulation of Epithelial William T. Ameredes Na and K Channels Tissue Response to Ischemic Injury: Adaptative Thomas R. Kleyman and Douglas C. Eaton and Rengenerative Strategies Reflex Regulation of Airway Function and Breathing David P. Basile and William Chillian Lu-Yuan Lee and Brendan Canning Integrated Cell Systems Nitric Oxide and the Cardiovascular System James Bassingthwaighte (Wiggers Award Featured Topic) Developmental Plasticity of Respiratory Control Allan Lefer Ryan W. Bavis Neurohumoral Control of Body Fluid Volume Evolution of Vascular Regulation From the Neonate and Arterial Pressure to the Aging Adult: Mechanisms and Functional Thomas Lohmeier and Richard Roman Consequences AstraZeneca Young Investigator Featured Topic Matthew Alan Boegehold Jeffrey Miner Central Neurons and Efferent Pathways Controlling Is it the Physiology, the Students, or is it Me? Thermoregulation Reflections on the Classroom Jack A. Boulant and Kazuyuki Kanosue Harold Modell Cardiovascular Physiology: From Bench to Classroom Trafficking of Membrane Transporters in the GI Tract Richard Bukoski and Charles Seidel and Beyond Development of Excitation-Contraction Coupling Curtis Okamoto in the Embryonic Heart: From Simplicity to Complexity Comparative Aspects of the Hormonal Responses Tony L. Creazzo to Metabolic Demands Oxidant Mechanisms in Neural Regulation Rudy M. Ortiz of Cardiovascular Function Identifying Genes and Targets in Cardiovascular Robin L. Davisson Autonomic Pathophysiological States Control of Coronary Blood Flow Julian Paton (Berne Lecture Featured Topic) Regulation of Vascular Smooth Muscle Cell Phenotype: Eric O. Feigl Contractile versus Proliferative Therapeutic Potential of Hypothermia: Bridging the Gap Usha Raj Between Clinical and Basic Thermoregulatory Research Hypertension (Starling Distinguished Lectureship Christopher Gordon and Michael Dae Featured Topic) Functional Brainstem Anatomy: Can We Tell Richard Roman Cardiovascular and Respiratory Neurons Apart? Insights on Renal Function and Blood Pressure Paul Gray Control From Genetically Manipulated Animals The Lung—A Very Special Place for Dendritic Cells Richard Roman Gabriele Grunig - The Molecular Physiology of HCO 3 Transport Interaction Between Histone Acetylation and DNA Michael Romero and Mark O. Bevensee Methylation New Insights on Neuro-Immune Interactions Alessandro Guidotti in Autonomic Regulation Intermittent Hypoxia: Physiological and Genomic Yvette Tache Consequences Hypoxic Metabolic Response: Autoregulation, Gabriel Haddad Acclimation and Adaptation Causes and Consequences of pH Variability in Vertebrates Glenn Tattersall Lynn Hartzler Arteriogenesis and Collateralization Glial/Neuronal Bi-directional Signaling Joseph L. Unthank Glenn Hatton Regulation of Ion Transporter Trafficking Preconditioning of Myocardium Against Infarction Wenhui Wang and Michael Caplan Franz Kehl and David C. Warltier The Regulation of Sympathetic Nerve Activity Epithelial Anion Channels: Structure, Form, Function in Chronic Heart Failure Kevin Kirk and Catherine Fuller Irving Zucker
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the legislative gridlock that dogged HUD appropriations bills, but the dif- Midterm Elections Cloud the 107th Congress. ferences between them still had to be Appropriations Future The big news for biomedical resolved by a conference committee. research in this election is the shift to The 107th Congress was scheduled In the election for the 108th full Republican control of Congress. to return for a lame duck session in Congress, Republicans came out However, it is too early to know pre- mid-November where a decision would ahead, picking up four seats in the cisely what this will mean. In the be made whether to finish the remain- House of Representatives. This in- Senate, all committee chairmanships ing FY 2003 appropriations bills or to creased their majority over the will change hands. This usually means pass a continuing resolution that Democrats to 227-206. The Republi- that the ranking Republican assumes would extend into the New Year when cans also picked up two Senate seats, the chairmanship, but sometimes a the 108th Congress convenes. Some giving them at least 51, with one race Senator opts to become the chair of a congressional leaders had said that undecided and still another race that different committee, and this can finishing FY 2003 appropriations could be challenged as of this writing. result in a cascade of other changes. should be on the agenda, but others Nevertheless, 51 seats are enough to Before the election Congress had expressed a preference for keeping the return the Republicans to the majori- passed only two of the 13 annual government operating at current lev- ty for the first time since June 2000. appropriations bills—Defense and els until as late as March to rein in The undecided Senate race is in Military Construction. Consequently, spending. This tactic would discourage Louisiana, where there will be a run- the rest of the government was left the NIH and other agencies from off. In the South Dakota race, incum- running at FY 2002 levels under a undertaking new initiatives because bent Senator Tim Johnson (D-SD) nar- continuing resolution that was sched- of uncertainty about their budgets. rowly beat out rival challenger uled to run out November 22. An update on appropriations for Representative John Thune (R-SD) by Biomedical research was left in an research agencies is provided in the a mere 528 votes. Under South Dakota especially precarious position. The chart below. ❖ law, Representative Thune is entitled NIH was hoping to receive the final to challenge the vote but he indicated installment in its five-year doubling. he would not challenge the result However, while the Senate had absent some indication of fraud or approved its NIH funding legislation, Animal Activists Indicted error in the tallies. the House Appropriations Committee This was an historic election had been unable to muster the votes to On October 25, 12 animal activists because the party that controls the produce an acceptable version of its were indicted in Boston, MA for stalk- White House usually loses seats in a Labor-HHS appropriations bill. ing an insurance company executive. midterm election. Nevertheless, the Funding for the NSF, VA, and NASA They believed this executive had ties Republican majorities in Congress are fared only slightly better. Both the to Marsh Insurance Company, a major very slim, which may do little to ease House and Senate had passed VA- insurer of United Kingdom based Huntington Life Sciences (HLS)-a
Table 1. FY 2003 Budget Update Agency/ President’s % Change FY 2003 % Change FY 2003 House % Change Conference Program Request FY From FY Senate Action From FY Action From FY Report 2003 2002 2002 2002
NIH $27.2 billion 17.0 $27.262 billion 17.0 Not complete N/A Not Complete S.Rept 107-216
NSF $5.028 billion 4.9 $5.353 billion 11.80 $5.422 billion 12.8 Not Complete S. Rept. 107-222 H. Rept. 107-740
VA Medical $409 million 10.2 $400 million 7.8 $405 million 9.1 Not Complete Research S. Rept. 107-222 H. Rept. 107-740
NASA Office of $842 million 3.4 Not Specified in N/A $854.2 million 19.6 Not Complete Biological and Report H. Rept. 107-740 Physical Research (OBPR)
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drug-testing firm that uses animals. members allegedly stalked the ing in violation of a restraining order, In fact, this person had nothing to do employee and vandalized his apart- and conspiracy. The most serious of with Marsh’s insurance brokerage ment building with red paint. They these charges is attempted extortion, business. also called him a “puppy killer,” which carries a maximum sentence of The activists were members of the demanded he quit his job and 15 years in prison and a fine of up American branch of Stop Huntington attempted to target him by publishing $5,000. This indictment highlights Animal Cruelty (SHAC), whose stated the names of his family members on just one of the recent incidents in goal is to use any means necessary in the web. The campaign culminated which SHAC has been a part of or order to shut down the British drug- with an August 2002 protest outside been associated with. testing firm. The group has harassed, the insurance executive’s apartment. In July 2002, smoke bombs in two intimidated and in some cases even Standing just a few feet away from the Seattle high-rises caused the evacua- assaulted not only Huntington’s man’s residence, the activists protest- tion of 700 employees. According to employees, but also people with rela- ed 24 hours a day using a megaphone Seattle Police Chief Gil Kerlikowske, tively distant ties to the company. to scream chants such as, “what comes the targets appeared to be insurance This includes its directors and around, goes around…burn his house companies whose clients conduct investors, as well as employees and to the ground.” This resulted in mem- research involving animals. Although investors in firms that do business bers of the group being charged with SHAC denied having any involvement with HLS. attempted extortion, threats to burn a in the incident, it applauded them: According to the indictment, SHAC dwelling, criminal harassment, stalk- “Although we do support direct action, as long as it doesn’t hurt any animal, human or non-human, we do not APS to Sponsor 2003 Mass Media Fellowship engage in, organize or fund such For the fifth consecutive year, APS tion of the APS website at actions,” SHAC website contends. will sponsor an American Association http://www.the-aps.org/awards/ “However, we do applaud those brave for the Advancement of Science awd_student.htm#AAAS. Additional enough to do so.” (AAAS) Mass Media Science and fellowships are available for students For a more in depth analysis of the Engineering Fellow for summer 2003. in other scientific and engineering Stop Huntington Animal Cruelty Applications are due to the AAAS by disciplines. Information about the Campaign and their actions please January 15, 2003. program is posted on the AAAS visit the Americans For Medical Progress The APS-sponsored fellow will be Education and Human Resources opposition research site at: http://www one of approximately two dozen Directorate website at http://ehrweb. .amprogress.org/ResearchOpposition/ ❖ AAAS Mass Media fellows who will aaas.org/massmedia.htm. A brochure ResearchOppositionList.cfm?c=19. spend 10 weeks during the summer with additional information about the working in the newsrooms of newspa- program is also posted on both web pers, magazines, Internet news out- sites. Animal Charities Get Poor Marks lets, or radio or television stations. In addition to the application form, Fellows will receive a short training applicants must submit a current for Stewardship course in science journalism prior to résumé, a three- to five-page sample the fellowship, and will spend the of writing directed to the general pub- Several major animal activist summer developing their ability to lic, transcripts of graduate and groups have come under renewed crit- communicate complex scientific undergraduate work, and three let- icism for their financial management issues to non-scientists and improv- ters of recommendation. Two of the practices. In October the independent ing public understanding of science. recommendation letters should be organization Charity Navigator issued The AAAS arranges placements at from faculty members, and the third a scorecard on the financial soundness participating media outlets as part of should be a personal reference. The of major charities. The ratings were the selection process. The fellowship selection process is designed to seek based on data from Form 990, which includes travel to Washington for ori- out qualified candidates especially charities are required to file with the entation and evaluation sessions at from under-represented communities, Internal Revenue Service. Its ratings the beginning and end of the summer, including African-Americans, Hispanics, awarded charities from zero to five as well as travel to the job site and a Native Americans, and scientists with stars depending upon their perfor- weekly stipend based upon local cost disabilities. mance. Nearly 1,750 of the nation’s of living. For more information or to receive a largest charities were evaluated, and Individuals must be currently copy of the application by mail, con- according to Charity Navigator the enrolled as a graduate or postgradu- tact Stacy Brooks in the APS majority “continue to be fiscally ate student of physiology or a related Communications Office. (Tel.: 301- responsible and financially healthy discipline to apply for the APS fellow- 634-7253; Email: sbrooks@the- organizations.” ❖ ship. The application form is avail- aps.org). However, several major animal able in the “Awards for Students” sec-
509 The Physiologist Public Affairs Vol. 45, No. 6, 2002
activist groups got low marks. The fundraising. HSUS also spent 61.4 lished the FSAP in 1993. According to Humane Society for the United States percent of its budget on program its IRS Form 990, FSAP is headquar- (HSUS) and its affiliate, the Humane expenses and 10.2 percent on adminis- tered at the same Norfolk, VA address Society International (HSI), and tration expenses. as PETA. Furthermore, its purpose is People for the Ethical Treatment of Charity Navigator also evaluated described simply as providing “sup- Animals (PETA) were among the 9.4 the lesser-known HSI, which serves as port” to a specified group of organiza- percent of the rated charities that got the international arm of HSUS. (Paul tions, including PETA, four of its sub- only one star because of their “poor” Irwin is the president of both organi- sidiaries, PCRM, and the Washington performance. Charities received this zations, and both list the same Humane Society. rating if they failed to meet industry Washington, DC address as their The FSAP board consists of three financial management standards and headquarters.) HSI reported total rev- people: Neal Barnard (president), performed well below most other char- enue of $1,918,700 for the fiscal year Ingrid Newkirk (director) and Nadine ities involved in similar activities. The ending in December 2001, with Edles (secretary). Barnard is also the Foundation to Support Animal Pro- fundraising costs of $0.19 for each dol- president of PCRM. Newkirk is also tection (FSAP) got zero stars—the lar it raised. HSI allocated 18.7 per- the president and director of PETA. lowest possible rating—for its “excep- cent of its budget for fundraising, 61 Edles has not previously been identi- tionally poor” performance. FSAP has percent for program expenses, and fied as holding positions in either close links to PETA and to the 20.3 percent for administration. organization, but her address on the Physicians Committee for Responsible Both HSUS and HSI were rated as form is the PCRM address. Medicine (which was not rated). Only “poor” performers as charities, receiv- Since FSAP’s existence was dis- 1.3 percent of the 1,750 charities ing one star out of a possible five. closed, there have been various specu- received a zero star rating. PETA reported total revenues of lations about its significance. It may Charity Navigator is a relatively $13,867,001 on its IRS Form 990 for serve to conceal actual expenses of the new organization (http://www.charity- the fiscal year ending July 2001. beneficiary organizations since fund- navigator.org). It evaluates short-term Charity Navigator calculated that raising or administrative expenses spending practices, including charity’s PETA spent a modest $0.16 to raise picked up by FSAP are kept off their “fundraising efficiency,” as well as how each dollar, and that it allocated 15.5 balance sheets. For example, Animal much of their budgets they allocate to percent of its functional expenses for People reports that in its fiscal years fundraising, programs, and adminis- fundraising, 81 percent for program 1999-2000, FSAP paid the mortgage trative expenses. The ratings are a expenses, and 3.5 percent for adminis- on the PETA headquarters and leased composite that also include several trative expenses. As a result, PETA’s the site to PETA, as well as conducted measures of the organizations’ long- performance merited one star on the mailings in the names of beneficiary term financial sustainability. Charity zero to five star scale. organizations. It may also provide a Navigator evaluates financial man- The Foundation to Support Animal way for wealthy PETA to quietly agement practices and does not Protection (FSAP) reported a budget channel funds to PCRM. According to address the quality of program con- of $2,358,625 for the fiscal year ending Animal People, in its fiscal year 2000 tent or purpose of the organization. June 2001. FSAP spent a whopping filing, FSAP’s sole reported program The rule of thumb is that charities $5.42 for each dollar it raised and allo- expense was a grant to PCRM in the should spend at least 60 percent of cated 44 percent of its functional amount of $432,524. The organization- their budgets on program expenses. expenses for fundraising. FSAP also al structure of FSAP certainly demon- Charity Navigator uses the IRS defini- allocated 10.8 percent for program strates the extent to which PETA and tion of program expenses to make this expenses and a hefty 45.2 percent for PCRM are intertwined. While PETA determination, which is less stringent administrative costs. Consequently, has engaged in wild publicity stunts, than the one recommended by the FSAP was rated as “exceptionally PCRM has sought to portray itself as a now-defunct National Charities poor” and received a zero star rating. dispassionate source of expert infor- Information Bureau. NCIB did not However, the unusually close ties mation. However, FSAP’s narrowly believe that direct mail appeals should between PETA and FSAP merit addi- defined purpose and tightly-controlled ever be counted as program expenses. tional scrutiny of both organizations. organization reveals an extraordinary The IRS allows such appeals for funds FSAP was virtually unknown until its degree of cooperation between the two to be considered program expenses if existence was disclosed a year ago by groups. the mailings also contain educational the activist publication Animal People. Other websites that provide finan- materials. This monthly newsletter does an cial information about nonprofits According to Charity Navigator’s annual investigative report on charity include http://www.give.org (Better report, HSUS reported total income of finances called “Who Gets the Business Bureau Wise Giving $57,177,692 for the fiscal year ending Money?” In its November 2001 report, Alliance) and http://www.guidestar.org in December 2001. It spent $0.30 for Animal People revealed that PETA (Philanthropic Research, Inc.). ❖ each dollar it raised and allocated 28.4 and the Physicians Committee for percent of its functional expenses to Responsible Medicine (PCRM) estab-
510 The Physiologist Book Review Vol. 45, No. 6, 2002
precisely the mutated gene. Lawrence DNA microarray expression analysis. Methods in Genomic Pinto and Joseph Takahashi discuss Two chapters in the book are devoted similar issues for identifying mutant to microarrays and gene profiling. Neuroscience genes in mutagenisis experiments. David Lockhart and Carrolee Barlow, Hemin R. Chin and Steven O. Moldin Their contribution provides practical and Károly Mirnics et al. provide good (Editors). information on chemical mutagenisis, general overviews of this technology Boca Raton, FL: CRC, 2001, including breeding schemes and theo- with a discussion of different types of 321 pp., illus., index, $119.95. retical considerations for designing arrays, their advantages, and a host of ISBN: 0-8493-2397-5. genome-wide mutagenisis experi- useful practical information. Károly ments. Steven Kanes et al. discuss the Mirnics et al focus their chapter on With the recent publication of drafts use of ENU chemical mutagenisis to microarray strategies for studying of the human and mouse genome discover genes relevant to psychiatric human tissue and present method- sequences, and advancements in disorders. This chapter includes a use- ological and analysis details that are molecular technologies, there could ful discussion of the various mouse specific for expression analysis in hardly be a more timely volume in the behavioral paradigms used for identi- human brain tissue. field of neuroscience than Methods in fying mutant behavioral phenotypes. Gene therapy, or gene transfer, is Genomic Neuroscience. Hemin R. Chin Descriptions of breeding schemes for another technology with great poten- and Steven O. Moldin have compiled mapping dominant, recessive and tial in neuroscience. Jürgen Hampl an excellent collection of chapters that modifier loci are included in both offers a description of methods of gene provides an overview of current tech- mutagenisis chapters. transfer to neural tissue, including nologies and their potential for under- Knockout and transgenic mouse viral vectors and grafting transfected standing gene-brain-behavior rela- techniques are two of the most power- cells. Much of this chapter is devoted tionships. The volume covers a wide ful and commonly used techniques for to potential therapeutic uses of this range of topics, from mutagenisis, characterizing gene function. technology, including disrupting transgenics and expression profiling, However, from the standpoint of tumor development or increasing to human genetic analysis. The author behavioral neuroscience, this tech- dopamine synthesis in Parkinson’s list is quite impressive, representing nique is fraught with complications disease. Neural stem cell technology is the leaders of each of the respective arising from developmental and another potential therapeutic topics. pleiotropic effects of the mutated gene. approach for neurodegenerative dis- The book begins with a chapter by Mark Mayford and Eric Kandel con- eases. Lorenz Studer and Ron McKay’s Sokolowski and Wahlsten discussing tribute a chapter discussing the sec- chapter provides details on deriving the concepts of gene-environment ond generation of transgenic mouse neuronal stem cells and in vivo trans- interactions. Most genetic experi- technologies; conditional and plantation and functional assessment. ments are performed in a well-con- inducible gene targeting. The use of CNS stem cells are likely to also be trolled environment, precluding the Cre-lox and tetracycline inducible sys- useful for identifying factors involved discovery of gene-environment inter- tems for creating region-specific and in neuronal differentiation. actions. The authors point out that inducible knockout mice are reviewed. The final two chapters discuss the genetic phenotypes may vary quite Gene trap approaches provide approaches and problems in human dramatically in different environmen- another strategy to identify genes genetics. These chapters discuss sta- tal contexts. The chapter provides involved in specific neurobiological tistical considerations for the use of some experimental design and statis- processes. Kevin Mitchell et al present genome scans and SNP analysis for tical considerations for examining a fascinating example of how this identifying genes involved in psychi- gene-environment interactions and technique can be tailored to focus on atric or neurological disorders. discusses how molecular technologies genes involved in brain development Overall, I found this book to be quite can be used to elucidate the mecha- and wiring. The technique involves informative and comprehensive. Some nisms of these interactions. randomly inserting into genes a DNA of the chapters are quite specific, pro- Several chapters discuss techniques sequence that encodes markers that viding details on methodology and for identifying gene loci responsible label the cell body and projections. reagents, while others were broader in for particular neurological pheno- The sequence disrupts the gene and scope. In general the book is ideal for types. Wayne Frankel discusses how the marker proteins are expressed in neuroscientist and physiologist wish- natural mutants can be used to identi- its place. By staining for the markers ing to be kept abreast of the current fy genes involved in neurological pro- and comparing fiber pathways in het- state-of-art technology in molecular cesses. This chapter reviews the use of erozygous and homozygous brains, it neuroscience. ❖ segregation and linkage analysis to is possible to identify genes involved map the chromosomal location of in the wiring of the brain. Larry Young mutant alleles, as well as follow-up The genomic technology that has Emory University transgenic strategies for identifying received the most fanfare recently is
511 The Physiologist Book Review Vol. 45, No. 6, 2002
Second, that cytoplasmic proteins are 1. The Na+ pump violates the laws Cells, Gels, and the Engines of delicately organized into a gel with a of thermodynamics by requiring a high density of charged groups that much larger (>10-fold) free energy Life. A New, Unifying selectively bind ions. Third, that this expenditure than is available in ATP protein-water gel is poised to undergo hydrolysis. Approach to Cell Function highly co-operative and very long- 2. Cellular function is maintained range “phase transitions” in response under conditions in which lipid mem- Gerald H. Pollack. ++ - Seattle, WA: Ebner and Sons, 2001, to the binding of ions like Ca ,ATP branes are disrupted by mechanical 3 320 pp., $55.00. , etc. Finally, that extracellular insult, detergents, organic solvents, or ISBN: 0962689513. solutes exist in thermodynamic equi- other outrages to hydrophobic integrity. librium with this cellular gel, not in an 3. Cellular electrical behavior is Glancing at the first paragraph of energy-consuming steady state. Cyto- inconsistent with the ionic theory + this book, I winced: uh-oh, here come plasmic Na is low not because it is based on selective transmembrane the epicycles. The story of Galileo’s pumped out of the cell, but because permeability. + experimental extirpation of the cellular water is a poor solvent; K is It is not my purpose to critique the Ptolemaic epicycles seems always to high because of specific binding to theory itself, which I consider non- foreshadow the pronouncements of negatively charged sites on cellular sense. Rather, I aim to review Pollack’s scientific revolutionaries claiming proteins. Thus, the cell is pictured as exegesis of this theory to his intended that the accepted view of something an exquisite kind of ion-exchanger, in audience: interested scientists with big—physics, biology, whatever—is which the interplay of solute binding little background in biology. Pollack rotten at its core and requires a radi- to sites and exclusion from cell water, writes in a most engaging style— cal paradigm-shift (another familiar both equilibrium processes control- vivid, colorful, and enthusiastic. His mantra in such circumstances). It’s lable by ligand-induced pan-cytoplas- prose is crystal-clear, he never equivo- the core of cell physiology that Gerald mic phase transitions, underlies all cates, and he puts great effort into Pollack sets out to extirpate here. He cellular behavior. making the central points and basic views the idea of a continuous lipid Pollack re-interprets many familiar logic stand out from the background. bilayer membrane, and the pumps, physiological phenomena in terms of Eschewing the resentful tone so often channels, and permeases that reside this picture. For example, ion channel associated with ignored scientific therein, as biological epicycles, “postu- proteins act not as transmembrane heretics, Pollack instead relishes the lates put forth to rescue attractive the- diffusion pathways, but as surface role of mischievous contrarian, and, as ories that otherwise would have col- receptors which undergo conforma- a result, the book is a fun read. lapsed...” Pollack thinks that every- tional changes and, as a result, cause Moreover, the pages are festooned one has got everything wrong. Cells long-range phase transitions in the with David Olsen’s imaginative illus- are not bounded by lipid membranes cytoplasm, transitions that alter the trations that acutely illuminate the acting as permeability barriers; ener- phase-boundary potential between unfamiliar ideas offered. But the skill- gy-consuming solute pumps, such as cellular gel and extracellular solution. ful writing fails to compensate for the the Na/K ATPase or the H+-coupled Likewise, kinesin does not “walk” intellectual flaccidity of the exposi- ATP synthase, do not exist as such; along microtubules but rather “surfs” tion. This would be an appallingly bad cellular electrical potentials do not along waves of conformational place for a biological novice to begin. I arise from selective ion flows down changes in the microtubule, suspend- will cite a few characteristic examples transmembrane gradients; muscle ed within a traveling halo of water- of broad, breathless assertions that contraction does not proceed from ATP structure disassembly linked to bind- melt away upon even superficial hydrolysis-driven conformational ing of ATP. Mitochondria act not as examination and that mislead the bio- changes in the myosin head. chemiosmotic machines but rather as logically naive reader. These ideas are, in the author’s platforms from which ATP shuttles to 1. The reader is told authoritatively phrase “orthogonal to convention;” nearby cytoplasmic proteins, where it that the Na+ pump violates the laws indeed, the book is a new exposition of delivers energy by binding and pro- of thermodynamics (p. 18), but is not the old “association-induction hypoth- voking local phase transitions. informed that the experiments leading esis” put forth by G.N. Ling, who has These are pretty wild notions, and to this conclusion have never been promoting it vociferously for the Pollack takes pains to explain why we appeared in a peer-reviewed publica- past four decades (see http://www. should embrace them, abandoning our tion, only in Ling’s monograph, which gilbertling.org for the flavor of that familiar view of cell membranes, why summarizes work he carried out in the discourse). What does this theory say? the standard view fails so badly as to 1950s. Likewise, consider the citation First, that cell water exists in a non- demand such a complete revision. (p. 34) casting doubt on the existence aqueous state, highly ordered by pro- With appropriate attribution to Ling, of a continuous lipid membrane, in tein surfaces, and is, thus, a poor sol- he describes three really big problems which ion permeability was unaffected vent for hydrophilic solutes like ions. with the membrane theory. by depletion of membrane lipids. The
512 The Physiologist Book Review Vol. 45, No. 6, 2002
citation is to a 1960 general review of merely an honest howler? I don’t Examples like this—in politics it’s red cell ion permeability containing a know, but in either case, the student called “disinformation”—pervade the short description of an unpublished will end up undereducated. book. It seems clear why Pollack experiment in which the passive per- 3. Asserting that the number of pro- explicitly directs his exposition at meability increased by only 20% after posed pumps is impossibly large, “those with minimal background in about 10% of red cell lipids “should” Pollack fingers an outwardly directed biology”—nobody who knows the facts have been extracted by exposure to tetracycline pump in bacteria (p 17) as will swallow this stuff. In our scientif- alumina (lipids were not actually mea- a particularly egregious ad hoc epicy- ic infancy in grad school, each of us sured). Does this result tell you that cle invoked to patch up the faltering dreamed of someday smashing re- the cell membrane doesn’t form a per- membrane idea. Inviting his audience ceived wisdom to smithereens, like meability barrier? to join him in throwing up his hands, Galileo or Darwin (neither of whom 2. The novice biologist is reminded he argues that such a pump is a priori had set out with any such intention). (p. 41) that certain organisms, such as ridiculous. How can you have a new Eventually, we all end up settling in to the wooly bear caterpillar, survive in pump for every new compound synthe- doing “normal science,” not because we ultra-cold climates, and then told that sized by organic chemists? Pollack are pathetic failures but because we this means that the freezing point of leaves it there, without even a whisper become genuinely fascinated with the cellular water is much depressed, as about the exciting, vigorous, and med- demanding details of specific prob- though it is in a non-aqueous state. In ically compelling field of multidrug lems. After reading this book, though, fact, water in most cells freezes slight- resistance transporters, several of I wonder if it’s unhealthy to have ly below 0oC, and the cold-resistance which have recently been seen at these dreams of glory at all and of arctic insects, which specifically atomic resolution. Regardless of whether it might be best just to ban arises from fascinating antifreeze pro- whether this is simple negligence or Thomas Kuhn and Karl Popper from teins, is an exception. Is this conflation determined tendentiousness, the the children’s section of the library. ❖ of a special property of an naive student at whom the book is extremophile with a general property aimed has missed out on something Christopher Miller of all cells a sly rhetorical device or awfully interesting. Howard Hughes Medical Institute Brandeis University
the focus of another outstanding con- ing with the pathophysiology, diagno- Neuropathic Pain: tribution in their series devoted to sis and treatment of neuropathic pain. progress in pain research and manage- The monograph can be divided into Pathophysiology and ment. Considering the fact that an three sections, the first dealing with estimated 5% of all patients with trau- the clinical characteristics of neuro- Treatment matic nerve injury suffer from pain, pathic pain (Chapter 1); the second 8% of stroke patients suffer from cen- with basic research and putative Per T. Hansson, Howard L. Fields, tral neuropathic pain, as do 28% of mechanisms of neuropathic pain Raymond G. Hill, Paolo Marchettini patients with multiple sclerosis, 40% (Chapters 2-8); and the third with (Editors), Progress in Pain Research of patients with Parkinson’s disease, treatment strategies (Chapters 9-13). and Management, Volume 21 and 75% of patients with syringo- The opening chapter by Hansson Seattle, WA: IASP, 2001, 277 pp., illus., myelia or spinal cord injury, it is easy provides an outstanding summary of index, $79.00. to appreciate the importance of this the clinical characteristics of neuro- ISBN 0-931092-38-8. topic. Although research in the field of pathic pain, as well as a commentary neuropathic pain is progressing rapid- on the current state of diagnostic and The past ten years have seen a sig- ly, the contents of this volume provides treatment strategies for this condition. nificant increase in basic and clinical a valuable overview along with This chapter also establishes the clini- research focusing on conditions, which descriptions of recently emerging cal dimensions of different neuropath- can be placed under the umbrella of information within the field of neuro- ic pain states. A timely perspective on neuropathic pain. In spite of a multi- pathic pain. This book represents a the relevance of current animal mod- disciplinary strategy involving state-of-the-art summary of two sym- els and behavioral outcome measures researches from around the world posia held in conjunction with the in studying the complexities of neuro- there remains significant shortcom- World Congress on Pain held in pathic pain is also provided. Emerging ings in our ability to treat patients August 1999. The volume contains from this chapter is the recommenda- with this condition. For this reason it contributions from an internationally tion that a continuing dialogue is is understandable why the Interna- recognized list of clinical and basic sci- needed between pain clinicians and tional Association for the Study of ence experts who address the latest pain scientists to enhance research Pain (IASP) has chosen this topic as clinical and scientific knowledge deal- (continued on page 514)
513 The Physiologist Book Review Vol. 45, No. 6, 2002
(continued from page 513) and Baron (Chapter 7). The pre- In conclusion this volume consists of related to the underlying mechanisms dictability of animal models and their short chapters dealing with the major of neuropathic pain. The opening relevance to the human condition is components of topics related to the chapter is followed by a series of seven discussed. Chapter 8 describes the use clinical characteristics, mechanisms chapters focusing on the pathophysiol- of postherpetic neuralgia as a poten- and treatment of neuropathic pain. ogy and possible mechanisms of neu- tial model for the study of neuropath- Each chapter is well-referenced and ropathic pain. These chapters focus on ic pain. provides an outstanding state-of-the- experimental studies dealing with Effective, long-term treatment of art review of research and clinical sodium channels, cytokines, peripher- neuropathic pain represents one of the practice related to this condition. The al and central sensitization, plastic biggest challenges in medicine today. volume offers the reader a fundamen- changes in chronic pain states and the Chapters 9-13 deal with treatment tal view of the landscape as well as an role of descending facilitatory path- strategies and focus on the use of account of recently emerging informa- ways in neuropathic pain. Chapter 5 antidepressants, anticonvulsants, tion in basic and clinical areas of neu- by Dickenson and colleagues provides opoids, local anesthetics and electrical ropathic pain. The contributors have an excellent summary of the central stimulation. An important considera- emphasized the importance of increas- changes that are thought to play a tion in this section of the book is ing our understanding of the mecha- critical role in the pathophysiology whether research related to mecha- nisms and clinical characteristics of underlying the onset and persistence nisms of neuropathic pain represents various conditions in hopes of promot- of chronic pain resulting from injury a viable strategy for identifying future ing the development of novel treat- to the peripheral or central nervous targets of therapeutic intervention. ments. The book represents a wealth system. Porreca and colleagues Mechanism-based approaches for the of high quality information for the (Chapter 6) add to the proposed treatment of neuropathic pain includ- basic scientist, as well as health pro- underlying mechanisms of neuropath- ing blockade of calcium and sodium fessionals, interested in neuropathic ic pain in their description of bul- channels, inhibition of cytokine pro- pain and emphasizes the importance bospinal facilitatory influences on duction, and the use of opioids are dis- of current and future research efforts spinal pain processing. Their contribu- cussed. An important underlying directed towards understanding the tion describes a novel component to theme of these chapters is the fact pathophysiology and identification of the mechanism of neuropathic pain that in spite of progress in predicting potential therapeutic targets. This vol- and typifies the way contributors have the diagnosis of different neuropathic ume is an outstanding reference for provided insightful interpretations of pain conditions what is lacking is a those interested in the field of neuro- their work. This chapter challenges way to predict the success of different pathic pain. It contains a comprehen- existing views on the mechanisms therapeutic interventions. The con- sive index, meets the high standards responsible for the onset and mainte- cluding chapter (14) provides an inte- of the IASP Press, and will serve as nance of neuropathic pain. Based on a grated discussion focusing on the cur- valuable reading for the established as comparison of research in animal rent state of scientific and clinical well as beginning researcher in the models and human studies the role of knowledge related to neuropathic pain field of neuropathic pain. ❖ the sympathetic nervous system in and a perspective on what to expect in Robert P. Yezierski neuropathic pain is provided by Janig the future. University of Florida y Experimental Biolog “Translating the Genome” Deadline: 2003 Call for Late-Breaking Abstracts February 26, 2003
Late-breaking abstracts will be accepted for special Abstract submission site: http://www.faseb.org/meet- poster sessions to be scheduled on Tuesday, April 15, ings/eb2003 2003. The purpose of the late-breaking abstracts is to Abstract Submission Fee: $60 give participants the opportunity to present and hear Questions contact: about new and significant material. Late breaking Experimental Biology 2003 Meeting Office abstracts will be published in an addendum to the Phone: (301) 530-7010 meeting program; they will not be published in The Fax: (301) 530-7014 FASEB Journal. Email: [email protected] Abstracts must be submitted electronically with pay- For information, including each Society’s preliminary ment of $60 and received on or before Wednesday, program, housing, and registration forms, see the EB February 26, 2003. 2003 Web Site: http://www.faseb.org/meetings/eb2003 Save Money! Register online by February 13 and make your housing reservations by March 7.
514 The Physiologist Positions Available Vol. 45, No. 6, 2002
251-460-6826; Fax: 251-460-6464, and three letters of reference to Albert Postdoctoral Positions Email: [email protected]. J. Sinusas, MD, Director of Animal Research Laboratories, Section of Postdoctoral Fellow: Human Card- Cardiovascu-lar Medicine, Yale iovascular-Integrative Physiology. A Postdoctoral Position: A postdoctor- University School of Medicine, PO Box position is open in the Faculty of al position is available to study the 208017, New Haven, CT 06520-8017; Applied Health Sciences, University of role of NFAT transcription factrons in Email:[email protected]. Waterloo for an individual with train- CD154 (CD40-ligand) gene regulation ing in human cardiovascular physiolo- in patients with systemic lupus ery- thematosus. Both murine and human gy. A background in mathematical Research Positions modeling and computing is an asset. studies are involved. A background in The research will focus on the study of immunology and/or molecular biology baroreflex function in various popula- will be useful. Candidates must have a Research Associate/Postdoctoral tions including young and older indi- PhD or MD. Salary is competitive and Positions: The University of Virginia viduals and astronauts. More informa- commensurate with experience. We Health System, Department of tion on the activities of the lab can be seek a creative, independent, and Pharmacology is seeking applications obtained from the web site: highly motivated individual to spend for Research Associate/Postdoctoral http://healthy.uwaterloo.ca/~hughson/ at least 2-3 years in the laboratory. positions to investigate mechanisms of cvlab.html. Candidates should send a Interested candidates should send a ion channel modulation. The success- CV and the names and Email address- curriculum vitae and names, address- ful applicant will apply diverse es of three references to: Prof. Richard es, and current phone numbers of approaches, electrophysiological and Hughson, Department of Kinesiology, three references to: Randy Q. Cron, molecular, in both cell culture and in University of Waterloo, 200 University MD, PhD, Children’s Hospital of native neuronal preparations to study Ave. W., Waterloo, ON, N2L 3G1 Philadelphia/University of Pennsyl- physiological roles of background K+ Canada or by Email to hughson@uwa- vania, 3615 Civic Center Blvd., ARC channels (see http://www.med.virginia. terloo.ca. The deadline for applica- 1102B, Philadelphia, PA 19104-4318. edu/medicine/basic-sci/pharm/bayliss. tions is December 1, 2002. Interested candidates may also send html). Experience in these areas is their credentials directly to mayoe@ desirable, but not essential. Appli- email.chop.edu. [EOE] cants at the PhD level will be consid- Postdoctoral Position in Endo- ered; salary will depend on qualifica- thelial Electrophysiology: A post- tions. To apply send resume to: Dr. doctoral position is available to study Postdoctoral Position: A postdoctor- Douglas A. Bayliss, Dept. of Pharm- mechanogated ion transport in differ- al position is available, effective imme- acology, PO Box 800735, University of ent endothelial phenotypes in the pul- diately, in molecular imaging pro- Virginia, Charlottesville, VA 22908- monary circulation and its role in gram, Section of Cardiovascular 0735; Email: [email protected]. mechanical stress induced vascular Medicine, Yale University School of (Application deadline: open until permeability and lung pathology. The Medicine. Position in multidisci- filled). [AA/EEO] recruited candidate will join an elec- plinary laboratory focused on targeted trophysiology group in a newly estab- imaging of myocardial angiogenesis, lished NIH-funded pulmonary vascu- coronary physiology, and myocardial Tenure-Track Scientist: The lar biology program emphasizing the mechanics. Laboratory employs small Laboratory of Kidney and Electrolyte role of endothelial phenotypes in calci- and large animal models of ischemia/ Metabolism (LKEM), National Heart, um signaling, cyclic nucleotide regula- reperfusion to develop non-invasive Lung, and Blood Institute, is recruit- tion and lung injury. Fluorescent imaging approaches for assessment of ing a Tenure-Track Scientist with microscopy, cell culture and gene myocardial angiogenesis. NIH-funded expertise in renal physiology and transfer core facilities are available. projects involve cardiovascular imag- epithelial transport physiology. The Recent electrophysiology studies are ing of large and small animals with successful candidate should have a included in: Wu et al. J. Biol Chem. multiple modalities, including: 3D PhD, MD or MD/PhD with training in 275:18887-96, 2000 and Brough et al. echocardiography, single photon emis- physiology, biomedical engineering, FASEB J. 15:1727-38, 2001. The can- sion computed tomography (SPECT), biochemistry, molecular biology, or a didate should have patch clamp expe- angiography, and magnetic resonance related discipline. Experience in ion rience and knowledge of cell culture imaging. Applicant should hold PhD transport physiology in renal tubule methods. Send curriculum vitae and and/or MD degree, and have strong epithelia is particularly desirable. names and addresses of three refer- background in cardiovascular physiol- Possible areas of specialization ences to: Dr. James C. Parker, ogy with some experience in immuno- include use of heterologous expression Department of Physiology, MSB 3024, histochemistry, animal surgery, or systems to study ion transporters, College of Medicine, University of imaging. Please send a statement of application of large scale genomics South Alabama, Mobile, AL 36688; Tel: research interests, curriculum vitae, techniques to the study of ion trans-
515 The Physiologist Positions Available Vol. 45, No. 6, 2002
port regulation, application of pro- and value to the person’s field or disci- nal support and experience in any of teomics methodologies to study ion pline. Desires considerable experience the following areas: 1) extracellular transport regulation, development of with the generation and design of matrix remodeling; 2) mechanisms of gene knockout models to study regula- recombinant viruses, and use and female cardioprotection; 3) calcium tion of salt and water excretion by the characterization of genetic models of signaling; and 4) cytokine-mediated kidney. LKEM has a long history of cardiovascular disease. Please send signal transduction. Applicants must technological innovation and a candi- resume and cover letter indicating have a PhD in bioengineering or phys- date is sought who can continue this #44679 to: Carol Wehby, Human iology. Send curriculum vitae, research tradition. The successful candidate Resources, Internal Medicine, E400 plan, and three letters of reference to: will be offered a competitive salary GH, 200 Hawkins Drive, Iowa City, IA, Dr. Greg Brower, Search Committee commensurate with experience and 52242-1081. [EEO/AA] Women and Chair, 106 Greene Hall, College of qualifications. Appointees must be US minorities are strongly encouraged to Veterinary Medicine, Auburn citizens, resident aliens, or non-resi- apply. University, AL 36849. Application dent aliens with a valid employment review will begin December 1, 2002 visa. Applicants should send a descrip- and continue until the position is tive letter of interest, curriculum vitae Research Associate/Scientist: A filled. Women and minorities are and bibliography, and arrange for position for a postdoctoral research encouraged to apply. The selected can- three letters of reference to be sent to: associate is available immediately to didate must be able to meet eligibility Ms. Christine Fisher, Human Re- work on a project that is currently requirements for work in the US at sources Branch, DHHS, NIH, National studying ovarian gene expression dur- the time of employment. [AA/EEO] Heart, Lung, and Blood Institute, 31 ing ovulation. Preference is for candi- Center Drive, MSC 2484, Bethesda, dates who have experience with differ- MD 20892-2484. Please include vacan- ential display, microarray, and/or Assistant Research Scientist: The cy identifier, HL-02-0120 on all corre- related techniques in molecular biolo- University of Iowa College of spondence. Applications must be gy. The individual must be willing to Medicine, Department of Internal received no later than January 8, become totally integrated into a small Medicine, Cardiovascular Diseases 2003. HHS and NIH are Equal research group in a well-equipped lab- Division, is seeking an Assistant Opportunity Employers. Applications oratory at a private, undergraduate, Research Scientist to perform basic or from women, minorities, and persons liberal arts institution. Candidates applied research to advance knowl- with disabilities are strongly encouraged. should be either a US citizen or a edge concerning defibrillation and Permanent Resident, and they should resuscitation. The work will require be willing to make a commitment of expertise in theoretical and method- Associate Research Scientist: The three years to the project. Applicants ological aspects of integrated cardio- Department of Internal Medicine, should send their CV (including vascular physiology. Requires a person Division of Cardiovascular Diseases, names and telephone numbers of in this classification has the academic University of Iowa College of three references) and a cover letter knowledge of a discipline that is gen- Medicine, is seeking an Associate stating their research interests via erally associated with a Doctoral Research Scientist to perform basic or Email to [email protected]. (No tele- degree, or an equivalent professional applied research on problems which phone calls will be accepted.) Trinity degree, i.e., MD, DDS, or DVM. In present critical or unusually difficult University is an Equal Opportunity addition, the person will have demon- obstacles to understanding and which Employer. Direct application informa- strated the ability to plan and execute involve the development of new theo- tion to Lawrence Espey, PhD, a research study through some pro- ries or methodologies with complete Department of Biology, Trinity gressively responsible independent responsibility for all aspects of the University, San Antonio, TX 78212; research work. Requires considerable research project. Requires a person in http://www.trinity.edu/lespey. experience with animal surgery, both this classification has the academic large (canine and porcine) and small knowledge of a discipline generally (mice, rats, rabbits). Desires experi- associated with a Doctoral degree, or Research Assistant Professor: ence with physiological research and an equivalent professional degree, i.e., Applications are invited for a 12- with cardiovascular surgical tech- MD, DDS, or DVM, and several years month research-track position at the niques, including endotracheal intuba- of postdoctoral or postgraduate assistant professor level in the tion, thoracotomy and Langendorff research experience. In addition, such Department of Anatomy, Physiology, isolated heart preparation, and inser- a person will normally have accumu- and Pharmacology to start March 3, tion of coronary arterial and coronary lated several years of progressively 2003. The Department is seeking an sinus catheters. Desires record of pub- responsible independent research individual to complement strengths in lications and evidence of grant appli- work. This work will be evidenced by ongoing cardiovascular research cations. Please send resume and cover publications, inventions and the like, focused on heart failure. Preference letter indicating #44686 to: Carol which have had considerable impact will be given to candidates with exter- Wehby, Human Resources, Internal
516 The Physiologist Positions Available Vol. 45, No. 6, 2002
Medicine, E400 GH, 200 Hawkins begun and will continue until the posi- Champaign invites applications for a Drive, Iowa City, IA, 52242-1081. tion is filled, ideally in early spring faculty position in Systems Physiolo- Women and minorities are strongly 2003. Confidential inquiries and gy. The successful candidate will encouraged to apply. [AA/EEO] requests for a Position Specification address fundamental mechanisms should be directed to the consultant involved in the functioning of organs assisting the search committee, E. Kay and tissues using molecular, genetic or Dawson, by Email (preferred) at computational approaches. Although Faculty Positions [email protected], or by telephone the Department has a particular at 503-292-4889. Applicants should interest in identifying outstanding Chair, Department of Biomedical submit a cover letter responsive to the candidates working in cardiovascular, Engineering: Oregon Health & Position Specification, a curriculum respiratory or renal physiology, the Science University (OHSU) vitae, and the names of five references excellence of the candidate is more announces a new department of to the search committee chair, Dr. important than the area of research. Biomedical Engineering and a search Misha Pavel, OGI School of Science & Because of recent success in filling for its first chair. Responsibilities: Engineering, 20000 NW Walker Road, positions in Neuroscience, applica- develop a unique focus for research Beaverton, OR 97006-8921. [EO/AA] tions in this area are not encouraged. and training; recruit outstanding fac- The position is full-time and tenure ulty and students; develop interdisci- track in the Department of Molecular plinary educational programs; build Tenure Track Assistant Profes- & Integrative Physiology in the collaborative linkages with the larger sors: California State University, College of Liberal Arts and Sciences university; foster partnerships with Northridge invites applications for and/or in the College of Medicine. the regional biotech community; tenure track Assistant Professors of Although we anticipate the appoint- secure external programmatic funding Biology in Mammalian Physiology to ment will be made at the Assistant and encourage technology transfer begin August 2003. Candidates must Professor level, applications for posi- and commercialization of research dis- hold a PhD in Biology, or related field, tions at the Associate and Full coveries. Qualifications: a strong back- and have postdoctoral experience. Professor levels will also be consid- ground in engineering or another Teaching includes Introductory ered; highly qualified scientists at quantitative science and relevant Biology, Cell Biology, graduate semi- these levels are encouraged to apply. experience within a biomedical field; a nars, and Human Physiology. The suc- The starting date for this position is record of success as an independent cessful candidate is expected to devel- August 2003. Appointment at the scholar; an entrepreneurial spirit; op a vigorous research program Assistant Professor level requires a capacity to represent the department involving undergraduate and gradu- doctoral degree, postdoctoral experi- effectively to external constituencies; ate (MS) students, seek extramural ence, and evidence of outstanding familiarity with commercializing research funding, demonstrate teach- research potential. Appointees at this intellectual property, a commitment to ing excellence, and provide effective level will be expected to develop a vig- translational research and successful instruction to students of diverse orous, independently funded research technology transfer; an understanding backgrounds in a multicultural set- program. Appointment at higher lev- of a research university’s role in the ting. Applicants should specify the els requires evidence of outstanding economic development of its region Physiologist position in a letter of research accomplishments including and state; a record of successful fiscal application and submit a curriculum extramural funding and national management and academic creden- vitae, summary of teaching experi- recognition. Applicants at all levels tials suitable for a senior faculty ence, statements of teaching philoso- will be expected to contribute effec- appointment. The Institution: OHSU phy and research interests, and three tively to undergraduate/graduate includes the first medical school west representative publications and teaching. The University of Illinois at of the Mississippi and Oregon’s first arrange to have three letters of recom- Urbana-Champaign has added sub- dental and nursing schools. Located mendation sent to: Chair, Department stantial faculty strength in the biolog- in Portland, it serves 2,600 students. of Biology, California State University, ical sciences over the last four years Its annual research budget is $160 18111 Nordhoff Street, Northridge, CA and additional hires in related areas million. In July 2001, OHSU expand- 91330-8303. Complete applications are anticipated each year for the next ed, by merger, with The Oregon must be received by January 10, several years. Successful candidates Graduate Institute of Science and 2003. will be provided with excellent labora- Technology. As OHSU’s new School of tory facilities, substantial start-up Science and Engineering, OGI serves funds, and a salary commensurate 300 students. Its annual research bud- Assistant/Associate/Full Profes- with experience. The University of get is nearly $20 million. Additional sor: The Department of Molecular & Illinois at Urbana-Champaign offers a information about both institutions is Integrative Physiology and the School highly interactive, interdisciplinary available at http://www.ogi.edu and of Molecular & Cellular Biology at the research environment and state-of- http://www.ohsu.edu. The search has University of Illinois at Urbana- the-art research support facilities.
517 The Physiologist Positions Available Vol. 45, No. 6, 2002
Urbana-Champaign offers the resi- physiology will be considered but spe- raphy, a brief statement of research dential advantages of a medium-sized cial consideration will be given to can- plan, and copies of key publications to: university city, excellent cultural didates with interests in blood pres- William S. Spielman, PhD, Depart- opportunities and easy access to sure regulation, microvascular circu- ment of Physiology, 2201 Biomed. Chicago and St. Louis. Information lation, or electrophysiology and signal Phys. Sci. Bldg., Michigan State concerning the School of Molecular & transduction in vascular tissue. University, East Lansing, MI 48824- Cellular Biology at the University of Preference will be given to individuals 3320; email: [email protected]. Illinois can be found at http://www.life. with demonstrated excellence in med- [AA/EEO] uiuc.edu/mcb/. Applications should be ical and graduate teaching. This posi- submitted to: Systems Physiology tion may be subject to criminal records Search, School of Molecular & Cellular screening in accordance with NM Law. Associate/Full Professor: The Biology, University of Illinois at For best consideration, applicants Division of Kinesiology at the Urbana-Champaign, 393 Morrill Hall, must submit a curriculum vitae, a University of Michigan seeks out- 505 S. Goodwin Ave., Urbana, IL short description of their research pro- standing candidates for full-time, 61801. An application must include a gram and the names of three refer- tenured faculty position in one of the curriculum vitae, with a complete list ences by December 15, 2002, howev- following areas: motor control/devel- of publications and a concise summary er, position will remain open until opment; biomechanics; exercise physi- of past research accomplishments and filled to: Nancy L. Kanagy, PhD, ology; and sport management. The future plans. In addition, four letters Associate Professor of Cell Biology and successful applicant must have an of recommendation should be sent to Physiology, University of New Mexico advanced degree in kinesiology or a the same address. Electronic submis- School of Medicine Albuquerque, NM related field and a nationally recog- sions, such as pdf files, are encouraged 87131-5218; Email: nkanagy@salud. nized record of funded research and and should be sent to mcbsearch@ unm.edu. [EEO/AA] scholarly publications. Applicants life.uiuc.edu. If submitting electroni- must have a history of successful doc- cally, please indicate that the applica- toral student training and be willing tion is for the systems physiology posi- Assistant/Associate Professor: The to contribute to the mentoring of tion. To ensure full consideration, Department of Physiology, College of junior faculty. Appointment will be applications should be received Veterinary Medicine, at Michigan made at the senior associate or full by January 20, 2003. Interviews may State University seeks applicants for professor level and will include a com- be conducted before the closing date a full-time tenure system position in petitive research and technical sup- but no hires will be made until after the area of animal biotechnology, as port package. Women and minority the search is closed. [AA/EEO] part of a larger effort to build a center candidates are particularly encour- of excellence around animal biotech- aged to apply. Please forward a nology as it relates to animal agricul- detailed letter of interest addressing Assistant/Associate/Full Profes- ture, and biomedical applications. The the requirements for this position, cur- sor: Applications are solicited for a candidate will be expected to develop riculum vitae, selected reprints, and tenure-track faculty position at the an independent research program the names, addresses, and telephone Assistant/Associate/Full Professor rank. directed at the underlying molecular numbers of three references to Susan Applicants must have a PhD and/or mechanisms of disease and who use H. Brown, PhD, Associate Dean for MD degree or equivalent and have germline modification approaches to Research, Division of Kinesiology, The completed postdoctoral training. their investigation. Applicants must University of Michigan, 401 Preference will be given to candidates have a PhD degree or equivalent, and Washtenaw Ave., Ann Arbor, MI with demonstrated productivity as special consideration will be given to 48109-2214; Tel: 734-763-6755; Fax: evidenced by extramural grant sup- candidates also holding the DVM 734-936-1925; Email: [email protected]. port, a strong publication record, degree. Candidates must have post- Review of applications will begin potential to develop a research pro- doctoral experience, demonstrate immediately; the position will remain gram in vascular smooth muscle regu- potential for developing a vigorous open until filled. For detailed informa- lation and endothelial cell physiology, externally-funded research program, tion regarding research activities and potential for interaction within and be capable of outstanding teach- within the Division of Kinesiology, the department and with relevant ing in the department’s education pro- please visit http://www.umich.edu/ clinical departments in the School of gram. Review of applications will ~divkines/kinweb/. [EEO/AA] Medicine. The successful applicant begin January 1, 2003, and continue will sustain an active research pro- until the position is filled. Applicants gram in physiology, employing con- should request letters of recommenda- Assistant Professor: The Movement temporary techniques to which inter- tion from three individuals who can Science and Education Program in the act with existing programs in vascular evaluate their accomplishments and Department of Biobehavioral Sciences smooth muscle regulation and future potential for research and at Teachers College, Columbia endothelial cell physiology.All areas of teaching. Please send CV and bibliog- University is seeking an applied exer-
518 The Physiologist Positions Available Vol. 45, No. 6, 2002
cise physiologist. Responsibilities: ing, teach at the undergraduate and committed to combining externally Teach graduate courses (e.g., exercise graduate levels, and advise and direct funded research with excellence in testing and prescription, assessment student research. The successful can- teaching. We investigate problems in a of physical activity, physical activity didate will be expected to complement diverse range of systems and we seek and health, physical activity in chil- Departmental strengths in human individuals who complement and dren and youth); supervise graduate lifespan physical activity (including extend these interests. Competitive student research; and conduct a aging), disability, disease or rehabili- salary and start-up packages are focused program of research. tation. Potential research areas relat- available. Additional information Qualifications: Earned doctorate in ed to exercise/physical activity include about the department can be found at exercise physiology or a related field molecular and cell biology, epidemiolo- http://www.science.duq.edu/biology.To and present evidence of successful gy, neurobiology, and cardiovascular apply, send a cover letter, CV, names teaching experience and research physiology. Laboratories exist both and contact information of three refer- accomplishments. Candidates are within the Department of Kinesiology ences, and statements of research and expected to demonstrate the potential and campus-wide to support research teaching goals to Dr. Steve Thomas, for sustained scholarship and the abil- in exercise physiology. Further infor- Faculty Search Committee Chair, ity to support a research program mation about the Department of Department of Biological Sciences, through external funding. Preference Kinesiology and current faculty can be Duquesne University, Pittsburgh, PA will be given to those candidates who found at http://www.kines.uiuc.edu. 15282. Review of applications will have ACSM certification and have had Qualifications: an academic back- begin December 2. Founded by the postdoctoral research or teaching ground in kinesiology or related field Holy Ghost Fathers, Duquesne experience. Rank: Assistant Professor, and the ability to teach one or more University is Catholic in mission and Tenure Track. Send CV, a cover letter, courses in kinesiology and exercise ecumenical in spirit. The University three representative publications, and physiology. A doctorate is required. values Equality of Opportunity both the names and contact information of Teaching and postdoctoral experience as an Educational Institution and as three references to Professor Stephen are preferred. Salary: Commensurate an Employer. Silverman, Search Committee Chair, with experience and qualifications. Box 126, Teachers College, Columbia Application Procedures: to assure University, 525 West 120th Street, full consideration, a letter of Assistant/Associate Professor: The New York, NY 10027; http://www.tc. application, vitae, and three let- Department of Pharmacology, Phys- columbia.edu. Review of applications ters of recommendation should be iology and Therapeutics University of will begin November 21, 2002 and submitted by February 1, 2003. The North Dakota, School of Medicine and continue until the search is completed. appointment will be effective August Health Sciences, (http://www.med.und. Appointment begins September 2003. 21, 2003. Interviews may be conducted edu/bimd/pharm.html) invites appli- Teachers College as an institution is before the closing date, but all applica- cations for a tenure track position at committed to a policy of equal opportu- tions will receive full consideration the Assistant/Associate Professor nity in employment. In offering educa- and the final decision will not be made level. The successful candidate will tion, psychology, and health studies, until after that date. Application contribute to team-taught courses for the College is committed to providing materials should be sent to Jeffrey A. graduate and medical students in sys- expanding employment opportunities Woods, Search Chair, Department of temic and cell physiology. Research to minorities, women, and persons with Kinesiology, University of Illinois at areas are open, but preference will be disabilities in its own activities and in Urbana-Champaign, 61-a Louise given to individuals with strong back- society. Candidates whose qualifica- Freer Hall, 906 South Goodwin grounds in cardiovascular physiology tions and experience are directly rele- Avenue, Urbana, IL 61801; Tel: 217- or pharmacology, and to those demon- vant to College priorities (e.g., urban 244-8815; Fax: 217-244-7322. [AA/EEO] strating potential for vigorous and minority concerns) may be consid- research programs supported by ered for higher rank than advertised. extramural funds. Candidates must Assistant Professor, Biology: Du- have a PhD, MD, or equivalent and at quesne University is seeking an assis- least two (2) years of postdoctoral Assistant Professor: The Depart- tant professor, tenure track, who uses experience. Review of applications will ment of Kinesiology at the University molecular, cellular, or organismal begin January 1, 2003, and continue of Illinois at Urbana-Champaign is approaches to explore basic physiolog- until the position is filled. Interested seeking qualified applicants to fill a ical questions. The successful appli- candidates should send a current cur- full time tenure-track position at the cant is expected to establish a vigor- riculum vitae, descriptions of research Assistant Professor level in the area of ous research program involving MS, and teaching experience, and names of Exercise Physiology. Candidates will PhD, and undergraduate students, three (3) individuals willing to serve be expected to contribute to interdisci- and to teach in the biology curriculum, as references to: Dr. Edward C. plinary research within the including a course in vertebrate phys- Carlson; Tel: 701-777-2101; Fax: 701- Department, seek extramural fund- iology. We are an interactive faculty, 777-2477; Email: ecarlson@medicine.
519 The Physiologist Positions Available Vol. 45, No. 6, 2002
nodak.edu; Search Committee Chair, Resources: c/o Michael B. Maron, PhD, respect to its faculty and librarian Department of Pharmacology, Phys- Professor and Chairperson, Depart- appointments. The designated groups iology and Therapeutics, Box 9037, ment of Physiology, Northeastern Ohio are: women, racial/visible minorities, University of North Dakota, School of Universities College of Medicine, PO persons with disabilities and aborigi- Medicine and Health Sciences, Grand Box 95, Rootstown, OH 44272-0095. nal peoples. Persons in these groups Forks, ND 58202. [AA/EEO] Review of applications will commence must self-identify in order to partici- November 29, 2002 and continue pate in the Affirmative Action until the position is filled. [AA/EEO] Program. The School of Kinesiology Assistant/Associate Professor: The and Health Science welcomes applica- Department of Physiology of the tions from persons in these groups. Northeastern Ohio Universities Assistant Professor: The York The Affirmative Action Program can College of Medicine (NEOUCOM) is University, Faculty of Pure and be found on York’s web site at seeking applicants to fill a tenure Applied Science, School of Kinesiology http://www.yorku.ca/acadjobs/ or a track (assistant/associate professor and Health Science, invites applica- copy can be obtained by calling the level) position in cardiovascular or tions for two tenure-track appoint- affirmative action office at 416-736- pulmonary pharmacology or physiolo- ments at the Assistant Professor level 5713. Canadian Citizens and perma- gy. The Department has a cardiopul- in exercise physiology for a starting nent residents will be considered first monary research focus and invites date of July 1, 2003. One position is in for this position. applicants who are using modern cel- the area of molecular muscle physiolo- Assistant Professor: The Depart- lular and/or molecular biology tech- gy and gene expression. A second posi- ment of Physiology of Morehouse niques to address integrative physio- tion is in either cardiac or vascular School of Medicine invites applica- logical problems that complement physiology, or in endocrinology and tions for a faculty position at the level ongoing research programs. Conve- metabolism. Knowledge of these areas of Assistant Professor. Applicants niently located near Akron, at the cellular and molecular levels should hold a PhD or MD degree and Youngstown, Canton, and Cleveland, would be an asset. The present have postdoctoral research experience. NEOUCOM is a community-based Masters and PhD programmes cover This recruitment is part of a depart- state medical school offering a com- health-related aspects of exercise mental expansion. Preference will be bined BS/MD program with the physiology, psychology, biomechanics given to the candidate who has experi- University of Akron, Kent State and fitness/epidemiology. Applications ence teaching medical physiology and University, and Youngstown State from individuals with an interest in who has established a funded inde- University. Further information about health and knowledge of the effects of pendent research program. While indi- the Department and Institution can exercise are particularly welcome. The viduals with expertise in all areas of be obtained from the NEOUCOM web opportunity exists for a cross-appoint- physiology will be considered, prefer- site at http://www.neoucom.edu. ment to the Graduate Programme in ence will be given to those whose pri- Candidates must have a PhD and/or Biology. Duties will include the super- mary interest is in cardiovascular or MD with appropriate postdoctoral fel- vision and teaching of graduate stu- respiratory physiology. Morehouse lowship training, a strong record of dents and undergraduate teaching. A School of Medicine has a wide array of research accomplishment, and the PhD and a promising publication core facilities and a Cardiovascular ability to establish an independent record in refereed journals are Research Institute with which faculty externally-funded program. Excellent required, as well as the ability to may affiliate. Candidates with exper- opportunities exist within the develop a productive research pro- tise in cancer research may be eligible Department and Institution for collab- gramme supported by external fund- for a Georgia Cancer Research Scholar oration. Medical student teaching ing. Postdoctoral experience would be award. Start date open. Interested responsibilities will be to participate a definite asset. Applicants should candidates should send their current in teaching the medical pharmacology send a curriculum vitae, a covering curriculum vitae and a statement of course. Departmental faculty are letter stating future research goals, research goals and teaching experi- members of the graduate faculty in relevant reprints, and have three let- ence to: Gordon J. Leitch, PhD, Chair, programs leading to the PhD through ters of reference sent by January 10, Department of Physiology, Morehouse the School of Biomedical Sciences at 2003 to: Dr. David Hood, School of School of Medicine, 720 Westview Dr., Kent State University. The successful Kinesiology and Health Science, York Atlanta, GA 30310; Fax: 404-752-1045; candidate will have the opportunity to University, 4700 Keele Street, Toronto, Email: [email protected]. develop graduate courses that relate Ontario, M3J 1P3; Email: to his/her specialty. To apply, candi- [email protected]. This position is sub- dates should send a letter of applica- ject to budgetary approval. Further Associate Professor: The School of tion describing research experience information about the School can be Applied Physiology at the Georgia and goals, accompanied by a curricu- obtained at http://www.kinesiology. Institute of Technology is soliciting lum vitae, and the names and address- yorku.ca. York University has an applications and nominations for a es of three references to Human Affirmative Action Program with tenure-track position at the rank of
520 The Physiologist Positions Available Vol. 45, No. 6, 2002
Associate Professor. Individuals from Access, the School of Psychology and didate will teach both non-majors and all related fields are encouraged to the College of Engineering, and at the majors as well as involve undergradu- apply, but primary consideration will Emory University School of Medicine ates in research. Areas of expertise be given to applicants with experi- with the departments of Physiology, might include, but are not limited to, mental experience in the cellular Cell Biology, Neurology, Pharmacology invertebrate zoology, systems physiol- mechanisms of skeletal muscle biology and Rehabilitation Medicine as well ogy, neurobiology, parasitology and with application to systems physiolo- as the Atlanta Veterans Administra- entomology. A PhD (by September gy. The successful candidate must tion Hospital. Interested individuals 2003), evidence of excellence in under- have an earned doctoral degree, an should send a letter of application, graduate teaching, and a commitment established record of scholarship and curriculum vitae, three recent publica- to undergraduate research are extramural funding and a documented tions and the names, addresses, Email required. Please send letter of applica- commitment to excellence in teaching, addresses and phone numbers of at tion, curriculum vitae, a description of service and research. The candidate is least three individuals we would con- research plans, a statement providing expected to develop a nationally recog- tact for letters of recommendation. your philosophy of teaching with a list nized research program at Georgia Applications will be reviewed begin- of potential course offerings, and Tech, participate in interdisciplinary ning immediately and continue until arrange for three letters of recommen- research activities, teach undergradu- the position is filled, but all material dation to be sent to: Chair, Search ate students and actively participate must be received by 12/31/02 to be Committee, Department of Biology, in the development of a graduate pro- assured of full consideration. Position University of Redlands, PO Box 3080, gram in applied physiology.The School to start August 2003, fall semester. Redlands, CA 92373-0999. Applica- of Applied Physiology is in the College Contact: Dr. Robert J. Gregor, School tions received by November 21, of Sciences, one of six colleges at the Chair, School of Applied Physiology, 2002 are assured full considera- Georgia Institute of Technology. 281 Ferst Drive, Atlanta, GA 30332- tion. Located in an ethnically and cul- Current faculty members are active in 0356; Tel: 404-894-3986; Email: turally diverse region midway the areas of biomechanics and the [email protected]. A unit of between Los Angeles and Palm neural control of movement, motor the University System of Georgia. Springs, the University of Redlands control and motor behavior, biomedi- [EEO] (http://www.redlands.edu) is a private, cal engineering and prosthetics and selective, liberal arts university orthotics, molecular biology and mus- enrolling approximately 2,200 under- cle physiology and systems physiology Biology Faculty Position: The graduates in the residential College of as applied to exercise. Collaborations University of Redlands invites appli- Arts and Sciences. The University of currently exist at Georgia Tech with cations for a tenure track faculty posi- Redlands is an Equal Opportunity the Center for Human Movement tion in Biology.We seek to broaden our Employer. We actively seek applica- Studies, the Center for Assistive existing offerings in animal biology at tions from members of under-repre- Technology and Environmental the systems level. The successful can- sented populations. ❖
Advertise your job vacancy to over 10,000 members and subscribers! Ads are accepted for either positions avail- lowing items are needed: a copy of the ad, able or positions wanted under all cate- the name of a contact person, and either a gories. The charge is only $75. All ads are purchase order number, credit card number also posted on the APS Career Opportunity (with expiration date and name of card- Web page for a period of three months. holder) or billing address. Send the infor- If you would like to have your ad listed in mation to Linda Comley (Email: The Physiologist and on the APS Career [email protected]; Tel: 301-634-7165; Opportunities Web page (http://www.the- Fax: 301-634-7242). aps.org/careers/car_pos_avail.htm), the fol-
521 The Physiologist News From Senior Physiologists Vol. 45, No. 6, 2002
Letter to Douglas Stuart much more satisfying than structural time to making toys out of wood. Toys studies. My exposure to physiological made from wood are so much more Jose Segundo writes: “It’s not quite thinking was reinforced by two profes- attractive and more friendly to the by return post that I answer the APS’s sors during medical school at the touch than the many toys on the mar- and your cordial message for my birth- University of Michigan. One, Louis ket made from plastic and other syn- day but, you must agree, better late Newburgh, professor of medicine, who thetic materials, especially if one can than never and, anyway, these lines in his small group sessions with stu- find plans for old 19th century toys, are no less sincere and heartfelt. The dents, analyzed clinical problems. It such as games, rocking horses and doll delay is due to my recently spending was fascinating to watch him demon- houses. I still own a 48-year old Sears several months in Montevideo, where strate how the application of basic sci- table saw, and up to now I still have all I am now, and get my mail about once ence in a rigorous and quantitative my 10 fingers. a month. fashion could lead to a more satisfying “Both my wife, Marion, and I love to “So please convey my many, many understanding of the clinical problem. travel. Travel has been very important thanks to the APS and your colleagues Dr. Newburgh’s expertise was in cias- in my professional career. I was fortu- for their friendly wishes. Needless to sic energy metabolism, nutrition, heat nate to attend and participate in many say, many thanks go to you, too. exchange, insensible water loss and international meetings. I have gotten “Cordially, your octogenarian friend obesity. The other was Fred Coller, to know many friends and colleagues and colleague.” professor of surgery. I expected in many European countries. It is surgery to be a specialty concerned always a pleasure to be able to meet Letters to Novera Herbert only with procedures and techniques. such old friends in many of the coun- Spector To my surprise I found a surgeon in tries we visit during our travels. A 1944 talking about salt and water bal- high point in our travels was the S. P. Masouredis writes: “Thank you ance and pre- and post-operative care opportunity to take our children and and the Society for your congratulato- based on physiological principles. I grandchildren to visit the villages of ry letter on the occasion of my 80th was also fortunate while in medical my parents in Greece. We all went to birthday and for the invitation to school to discover Physiological the island of Chios to visit the village write a note for The Physiologist. Reviews and was impressed with the where my mother was born and then “I must confess your letter was scholarly discussion of many interest- to the southern Peloponese to visit the totally unexpected. At the time of my ing physiological topics. With such an village of my father on the slope of Mt. election to the American Physiological exposure one can appreciate my Taigitos. On our last visit to Paris I Society in 1957 I had published only respect for the physiological sciences. visited the famous Cimetiere du Pere- one paper in the American Journal of “After medical school I went to Lachaise to look for the grave of Physiology, in 1953, which compared Berkeley to learn about radioisotopes Claude Bernard who is buried there. I the intravascular and extravascular and obtained a PhD in medical found the graves of many famous peo- distribution of iodide-131 in the physics. Most of my subsequent publi- ple, Chopin, Sarte, and Collete but was guinea pig and of 1-131 labeled rabbit cations exploited radioisotopes in unable to find Claude Bernard. This globulin in the guinea pig and rabbit. immunological and hematological was due in part to the fact that my However, I had published some 10 studies. daughter and the granddaughters had papers in other journals some of which “I have enjoyed my retirement. I the map showing the location of the involved physiological studies, such have always enjoyed working with gravesites, since my granddaughters as, blood flow in the human leukemic wood and using tools. When I was very were determined to find the grave site bone marrow, comparative behavior of young, elementary school, a family of the rock star, Jim Morrison. Rather l-131 and C-14 labeled albumin in friend who owned a grocery store then being upset at our failure to find man. My experimental work drifted saved wooden fruit crates for me. With Claude Bernard we now have an into other disciplines, primarily Woolworth dime store tools, which excuse to plan another trip to Paris. immunology and hematology. were inexpensive and worked very “It is difficult to find the appropriate “Even though I published only one badly, I was able to dismantle the words of wisdom after these many paper in the Society’s journals, I boxes, remove the nails and make sim- years. For what they are worth I would prized my membership in the ple toys, such as wooden boats with say: always do your best, try to appre- American Physiological Society. My rubber band-powered paddle wheels. ciate and seize the opportunities that respect and admiration for physiology It was and still is a joy to make things come your way, have a good time, and developed while in medical school in with your hands, a skill that was very most importantly enjoy your work.” the mid 40’s. The only medical text- useful in my research. book that fascinated me was “On retirement I was able to devote J.H.U. Brown writes: “I was sur- Best&Taylor. In addition, ideas such much more time to wood working. I prised and delighted to receive the as Claude Bernard’s “milieu interne” embarked on furniture making and beautiful plaque on my fiftieth year and Walter Cannon’s concept of home- learned many new skills, such as how with APS. I have almost lost contact as ostasis, which provided explanations to make tambour doors. With three I switched fields. After becoming and understanding of function were so grandchildren I began to devote more chairman of the Physiology Depart-
522 The Physiologist News From Senior Physiologists Vol. 45, No. 6, 2002
ment at Emory Medical School, I the study of the circulation in the American College of Cardiology; and became a Director at NIH and then limbs in man. To Barcroft, the kindest the James B. Herrick and the Laennec Associate Administrator in HSMHA. man I have ever known, I owe my Awards from the American Heart Both related to medicine but were con- career in research. I published my Association. I received an honorary cerned with instrument development, first paper, ‘On the Action of MD degree from Trinity College etc. At that time I formed with Noradrenalin on the Human University of Dublin and honorary fel- Biomedical Engineering Society and Circulation,’ in 1949 in Lancet. lowships from the Hebrew University turned my attention in that direction. Barcroft honored me as co-author of in Jerusalem, and the Royal College of Although I am a physiologist I was his ‘Sympathetic Control of Human Physicians of Ireland. I published my proud to be elected to the National Blood Vessels. Monographs of the first paper in 1948. My most recent Academy of Engineering. Physiological Society.’ No.1 (1953). It book chapter has just appeared and I “During my time at HSMHA I was is interesting to note, half a century have another manuscript in press. fortunate to manage the project for later, that we had reported an anoma- Over the years, I have enjoyed a won- NIH which produced the first personal lous response in calf blood flow to derfully productive group of col- computer (LINC) as documented in increasing concentrations on intraar- leagues, including William Ganz, the Museum of Computer Sciences. I terial adrenalin, and suggested the William Parmley, M.M. Laks, James reached retirement age at that time transient initial vasodilatation might Forrester, George Diamond, Dan and moved to San Antonio as Director be due to liberation of a second trans- Berman, and others. Collectively we of the Research Consortium, which mitter ‘when adrenalin reaches the published over 1,000 manuscripts was designed to unite biological and periphery it causes the momentary from Cedars-Sinai in the course of physical sciences. Three years later I liberation of a vasodilator substance close to 40 years. My greatest satisfac- was offered the position of Associate from the arterioles which is swept on tion comes from my association with Provost of the University of Houston. and causes transient dilatation of the Cedars-Sinai where I and my staff Two projects interested me. In con- pre-capillary-sphincters’ (p. 22.- enjoyed extraordinary cooperation junction with NASA and Sumitomo EDRF). H.H. Dale FRS was my thesis from the private Attending Staff, the (Japan) we devised and tested a new advisor for a PhD degree in 1951. Board of Directors, Hospital Manage- medical record system which would “I was awarded a two-year position ment, the volunteers, and the volun- put 4.5 megabytes of information on a of Research Associate at the Mayo tary community support groups which credit card. I became interested in two Clinic and the new field of cardiac made possible the organization of a non-profit organizations. We provided catheterization under the astute direc- highly productive Division of information about the formation of tions and rigorous discipline of Earl H. Cardiology. Finally, with complete small for profit business (many scien- Wood, to whom I also indebted for any retirement in 1994, I anticipated more tists were in the group) and Executive career success I may have enjoyed. I time at our second home in Sunriver, Service Corps, which served as an renewed my friendship with John T. OR, the pleasures of life in Pasadena, advisor to non-profit companies in Shepherd, also a Barcroft graduate and my rose, flower and vegetable gar- securing patents, etc. I became and fellow Irishman. After 14 years, I den. And so it was. Chairman of the 70 member chapter decided to move on and have spent the “But another, more difficult chal- which had been the best in the nation subsequent 35 years at Cedars-Sinai lenge lay ahead. On March 8, 2001, my and later the District Director to an Medical Center in Los Angeles, a large right leg ‘went out’ and I fell in the area of several chapters. community hospital and one of the five shower. Rapid recovery indicated a “I am now 84 and still working. I teaching hospitals of the University of TIA. I went to my local hospital, walk- have written several books in the California, Los Angeles (UCLA) School ing normally into the emergency room fields mentioned above since retire- of Medicine. I became Director of the and with no impairment of motor ment and still counsel in small busi- Division of Cardiology at Cedars-Sinai function, and anticipating prompt ness areas and have some 50 clients and Professor of Medicine at UCLA. In anti-coagulation. But the admission, per month on the Internet.” that position, I moved from physiolog- evaluation and decision making pro- ical research to a more applied field, cess was painfully slow. As time Letter to Karlman Wasserman namely, clinical cardiology and clinical passed, I recognized a progressive loss investigation in cardiovascular dis- of right motor function. As a conse- Harold James “Jeremy” Swan eases. Hence, my academic activities quence, I ended up with a completed writes: “I turned 80 on June 1, 2002. became more appropriate to organiza- stroke and a severe right hemiparesis. Born in Sligo on Ireland’s west coast tions such as the American College of The neurologist termed it as ‘dense,’- in 1922, I graduated from St. Thomas’s Cardiology and the American Heart meaning bad! However, I have my Hospital Medical School (Univ. of Association and found myself moving sight, speech, swallowing, and I London) in 1945. After Boards in away from the APS. believe, most of my marbles. But, as Medicine (M.R.C.P.) and military ser- “The highlights included: Presiden- W.B. Yeats put it in his poem-1916, ‘All vice in Iraq, I joined Henry Barcroft cy of American College of Cardiology is changed. Changed utterly,’ and FRS in 1948 as a research associate in (1972-1973); Master: The American indeed, it is, and for the rest of my life. College of Physicians; Master: The A never-smoker, mild hypertension,
523 The Physiologist People & Places Vol. 45, No. 6, 2002
slightly overweight, on lipid-lowering relearning elementary motor function, optimistic for a further improvement, drugs, using a calcium-channel blocker neural tracts and reconnect neurons. If but remarkably accepting of my limi- and intermittent aspirin. Neverthe- that really does occur post-stroke, it tations, since I have so much—a loving less, it happened.” takes a darn long time. However, my supporting wife and family whose care “A lot of my thoughts now go to spirits are good and I remain not only and affection have carried me so well.” Robillard Appointed as New Dean Jean Robillard, professor and an international reputation, and the search committee. We worked very chair at the University of Michigan people of Iowa are so nice. I’ve been hard to get that list of candidates from Medical School Department of there before so I know that. And the around the country. The other candi- Pediatrics, has been appointed to be faculty is fun to collaborate with.” dates were very good. It was a very dif- the new dean of the University of Iowa Robillard received bachelor’s and ficult choice.” Roy J. and Lucille A. Carver College of medical degrees from the University of Robillard said he plans to focus on Medicine. Robillard also serves as Montreal. He did an internship at the two areas when he joins the faculty at physician-in-chief at C.S. Mott Hotel Dieu Hospital and a residency in the UI. “It’s so important to make sure Children’s Hospital. He will begin his pediatrics at Ste. Justine Hospital in to recruit excellence in the chairs of tenure at Iowa on February 1. Montreal. He was a fellow in pediatric the departments, Robillard said. “It’s According to the Iowa City Press- nephrology at the University of an important responsibility in devel- Citizen, “It was the strength of the uni- California Medical Center in Los oping the strength of the place.” ❖ versity and the strength of the College Angeles before coming to the UI in 1974. of Medicine,” Robillard said of his “We’ve got a wonderful dean,” said choice to apply at the UI. “They have Francois Abboud, chairman of the M. Ian Phillips Receives Frank Annunzio Award The Christopher Columbus Fellow- The awards ceremony took place in ship Foundation announced that APS Washington, DC, following the 90th Member M. Ian Phillips, PhD, of the annual celebration in honor of University of Florida College of Christopher Columbus. Phillips is one Medicine, is the recipient of a $50,000 of four Frank Annunzio Award recipi- Frank Annunzio Award in the ents this year. The Foundation’s Board Science/Technology field for his three of Trustees has selected Annunzio decades of research on cardiovascular Award recipients annually since 1998. disease. The Christopher Columbus Fellow- Philips has developed new ways of ship Foundation is an independent treating hypertension with gene ther- Federal government agency estab- apy. Phillips’ team also developed a lished by the US Congress in 1992 to gene “switch” that “turns on” protec- “encourage and support research, tive genes when a heart attack begins study and labor designed to produce in response to oxygen deprivation. new discoveries in all fields of endeav- This “vigilant vector” provides cardio- or for the benefit of mankind.” protective genes to reduce heart dam- Governed by a Presidential appointed age from repeated attacks. Phillips M. Ian Phillips Board of Trustees, the Foundation has believes this technique could be Born in the United Kingdom, established Frontiers of Discovery- applied to a host of other chronic dis- Phillips received his Bachelor of Work in Progress and Discover the eases, such as diabetes, stroke and Science in Zoology/Psychology from Future programs that recognize “cut- lung disease. the University of Exeter, his doctorate ting edge” innovation, innovative “Innovative research in gene thera- in Neuropharmacology and his DSc in ideas of America’s youth and honor py has the potential to provide great Physiology/Pharmacology from the teachers. These programs include the benefits to society,” said Rosalyn University of Birmingham. He came to $200,000 Frank Annunzio Awards, Queen Alonso, Chair of the the United States as a postdoctoral Christopher Columbus Awards, Foundation. “Dr. Phillips’ work reflects fellow to conduct brain research at the National Gallery for America’s Young the level of discovery we look for in all University of Michigan and the Inventors and the $10,000 Freida J. of the Foundation’s Columbus California Institute of Technology. Riley Teacher Award. ❖ Scholars.”
524 The Physiologist People & Places Vol. 45, No. 6, 2002
APS Congratulates 2002 Lasker Award Winner Willem J. Kolff APS member Willem J. Kolff was pioneering work is responsible for the named the co-recipient the 2002 dramatic drop in mortality from acute, Albert Lasker Award for Clinical reversible kidney failure and prolong- Medical Research. He was honored for ing and improving the lives of count- developing the first useful artificial less individuals. kidney (hemodialyzer). Kolff shares Kolff is a professor emeritus of his award with Belding H. Scribner. surgery and medicine, at the Univer- Kolff’s initial goal was to create a sity of Utah School of Medicine. Aside device that would filter his patient’s from his work with the hemodialyzer, blood through bouts of acute kidney he has participated in the develop- failure. The hemodialyzer would send ment of numerous other artificial the blood through a cleansing solution organs including the artificial heart. that would remove metabolic byprod- He has been an APS member of since ucts, thereby performing the job of a 1956. As a recipient of the award often normal functioning kidney. Kolff called the “American Nobel,” he joins developed the artificial kidney in the the ranks of some of the world’s most Netherlands through Nazi occupation renown scientists. The APS extends its and the outbreak of World War II in Willem J. Kolff sincere congratulations to Dr. Kolff for Europe. He achieved his first success urine again and she went on to live for both his latest achievement and his in 1945 when he effectively filtered seven more years. Though others have lifetime of groundbreaking research. the blood of a 67 year-old woman. The further developed and reproduced this ❖ woman’s kidney began to produce technology many times over, Kolff’s
Gregory C. Amberg has affiliated Senior Scientist. Prior to his new affil- Kerman was with the Department of with the University of Washington iation, Coles was with the Department Otolaryngology, University of Pitts- School of Medicine, Seattle, WA, as a of Biomedical Engineering, University burgh, Pittsburgh, PA. Senior Fellow. Prior to his new assign- of Minnesota, Minneapolis, MN. ment, Amberg was associated with the Steven R. Kleeberger recently Department of Physiology and Cell Hesam Dehghani has associated joined the National Institute of Biology, University of Nevada School with the Department of Physiology, Environmental Health Science as of Medicine, Reno, NV. School of Veterinary Medicine, Laboratory Chief, Research Triangle Ferdowsi University of Mashhad, Park, NC. Kleeberger moved from the Lee E. Brown moved to California Mashhad, Iran. Dehghani formerly Department of Environmental Health State University as Associate Profes- was with the Department of Science, Johns Hopkins University, sor, Division of Kinesiology and Biochemistry, University of Guelph, Baltimore, MD. Health Promotion, Fullerton, CA. Canada. Brown had been with the Department Dietmar Kültz is currently Assistant of Health, Physical Education, and Sudhansu K. Dey is currently affili- Professor Physiological Genomics, Sport Sciences, Arkansas State ated with the Department of Animal Sciences, University of University, Province, AR. Pediatrics, Division of Reproductive California, Davis, CA. Kültz had been and Developmental Biology, Vander- with the Whitney Lab, University of Inyeong Choi has accepted a posi- bilt University Medical Center, Florida, St. Augustine, FL. tion with the Department of Nashville, TN. Prior to his new Physiology, Emory University School assignment, Dey was with the Michael A. Kurz has accepted the of Medicine, Atlanta, GA. Prior to his Department of Physiology, Kansas position of Director, Cardiovascular new affiliation, Choi was affiliated University Medical Center, Kansas Medical Affairs, Centocar, Inc., with the Department of Cell and City, KS. Malvern, PA. Kurz was previously the Molecular Physiology, Yale University Senior Clinical Scientist for Centocar, School of Medicine, New Haven, CT. Ilan A. Kerman recently affiliated Inc., Avon, IN. with the Mental Health Research James Allen Coles has joined Institute, University of Michigan, Ann Julian Estrella Mesina is now Medtronic Inc., Minneapolis, MN, as a Arbor, MI. Prior to his new position, Director, MLAS Biomedical Graduate
525 The Physiologist People & Places Vol. 45, No. 6, 2002
Studies, Drexel University, Philadel- Solomon Silas Senok affiliated with Brian J. Whipp is currently a mem- phia, PA. Mesina was formerly affiliat- the Department of Physiology,Arabian ber of the Respiratory & Critical Care ed with the Department of Physiology, Gulf University College of Medicine, Physiology and Medicine, Harbor- Lake Erie College of Osteopathic Manama, Bahrain. Prior to his new UCLA Medical Center, Torrance, CA. Medicine, Erie, PA. assignment, Senok was with the Before his new affiliation, Whipp was Department of Psychology, University with the Center for Exercise Science Benjamin F. Miller recently joined of Stirling, Scotland, UK. and Medicine, University of Glasgow, the Sports Medicine Research Group, UK. Bispebjerg Hospital, Copenhagen, Scott E. Sinclair accepted a position Denmark. Miller had previously been with the Department of Medicine, Johannes F. Zanzinger accepted a associated with the Department of Pulmonary and Critical Care Med- position with the Department of Integrative Biology, University of icine, University of Tennessee Health Research and Development Coordina- California, Berkeley, CA. Science Center, Memphis, TN. Sinclair tion, Boehringer-Ingelheim Pharma was previously associated with the KG, Biberach, Germany. Zanzinger Ryan Joseph Monti has affiliated Division of Pulmonary and Critical had recently been Principal Scientist, with the School of Dentistry, Care Medicine, University of Pfizer Ltd., Sandwich, England. University of California, Los Angeles, Washington, Seattle, WA. CA. Monti was formerly associated with the Department of Organismic Scott Alan Spier joined the Depart- Evolutionary Biology, Harvard ment of Health & Kinesiology, Univer- University, Bedford, MA. sity of Texas at Tyler, TX. Spier was formerly a Research Assistant with Paul M. O’Byrne recently joined the Texas A&M University, College Department of Medicine, McMaster Station, TX. University Health Sciences Centre, Experimental Hamilton, Ontario, Canada. Prior to Douglas H. Sweet has joined the his current position, O’Byrne was affil- Medical University of South Carolina iated with the Firestone Chest & as Assistant Professor, Charleston, Allergy Unit, St. Joseph Hospital, SC. Sweet had been a Project Biology Hamilton, ON, Canada. Scientist, Department of Medicine, University of California, San Diego, La Yves Ouellette has accepted a posi- Jolla, CA. tion with the Pediatric Department, 2003 Mayo Clinic, Rochester, MN. Prior to Glenn Jeffery Tattersall has moved his new appointment, Ouellette was to the Department of Biological with the Department of Pediatrics and Sciences, Brock University, St. Physiology, Children’s Hospital Catharines, Ontario, Canada. Prior to Important Western Ontario, Canada. his new assignment, Tattersall was affiliated with the Department of Darby Stewart Petitt has joined the Zoology, University of British Deadlines Department of Kinesiology and Columbia, Vancouver, BC. Applied Physiology, Human Cardio- vascular Research Laboratory, Univer- Paloma Valverde joined the sity of Colorado, Boulder, CO. Prior to Nutrition and Vision Department, Early Registration her new position, Petitt was a student USDA-HNRCA at Tufts University, of Exercise Science at the University Boston, MA. Valverde was formerly of Georgia, Athens, GA. with the Department of Oral Biology, Deadline The Forsyth Institute, Boston, MA. Philip Posner has moved to the February 13, 2003 Department of Biomedical Sciences, Ping Wang has affiliated with the Florida State University College of Department of Surgery as Chief, Medicine, Tallahassee, FL. Posner pre- Division of Surgical Research, North viously was affiliated with the Shore-Long Island Jewish Medical Department of Anatomy, Physiology, Center, Manhasset, NY. Wang had pre- Housing Deadline and Pharmacology, Auburn Univer- viously been associated with the sity, Auburn, AL. Department of Surgery, University of Alabama, Birmingham, AL. March 7, 2003
526 The Physiologist Announcements Vol. 45, No. 6, 2002
31st Annual Pediatric Trends Course
This course has been designed to fill problem-oriented approach is empha- 37.25 hours in category 1 credit the current needs of pediatricians, sized. toward the AMA Physician’s family practitioners and allied health The Johns Hopkins University Recognition Award. Each physician professionals interested in the care of School of Medicine is accredited by the should claim only those hours of cred- infants, children and adolescents. In Accreditation Council for Continuing it that he/she actually spent in the its 31st consecutive year, Pediatric Medical Education to sponsor continu- activity. Trends is designed to review recent ing medical education for physicians. For more information, contact: advances in biomedical and behav- The Johns Hopkins University School Office of Continuing Medical ioral sciences, which will have an of Medicine takes responsibility for Education, Johns Hopkins University impact upon the health and medical the content, quality and scientific School of Medicine, Turner 20, 720 care of children from fetal life through integrity of this CME activity. Rutland Avenue, Baltimore, MD adolescence. Combining lectures in The Johns Hopkins University 21205-2195; Tel: 410-955-2959; Fax: pediatric science, clinical demonstra- School of Medicine designates this 410-955-0807; Email: cmenet@jhmi. tions, conferences and symposia, a educational activity for a maximum of edu; Web: http://www.med.jhu.edu/cme. ❖
International Course on Laboratory Animal Science A two-week intensive international Federation of European Laboratory forms please contact: Prof. dr. L.F.M. course on laboratory animal science Animal Science Associations van Zutphen or Mr. Stephan van will be organized at the Department of (FELASA) regarding the training of Meulebrouck, Department of Labora- Laboratory Animal Science, Utrecht, the young scientist whose research tory Animal Science, Faculty of The Netherlands, in May 2003. involves the use of vertebrate animals. Veterinary Medicine, PO Box 80.166, The objective of the course is to pre- The course may also be of interest 3508 TD Utrecht, The Netherlands. sent basic facts and principles that are for those who intend to set up a simi- Tel: 31-30-2532033; Fax: 31-30- essential for the humane use and care lar course at their location. For this 2537997. Email: [email protected]; of animals and for the quality of purpose, during the course the acquisi- Internet: http://las.vet.uu.nl and click research. tion of teaching materials can be dis- on “Education.” ❖ The contents of the course are in cussed with the course committee. line with recommendations of the For information and application
Laboratory Animal Science A Preparatory Course for American Association for Laboratory Animal Science Certification Examinations
Learn the skills and techniques uate course that is being offered to Thursday evenings from 6:10 pm - required to start a career in a continuing professional education stu- 8:50 pm (including laboratory time), research lab. This hands-on course is dents. It is excellent preparation for January 21 through May 1, 2003. designed to prepare participants to the AALAS Certification examina- Register before January 5, 2003 for a work in a research institution where tions. More than 95% of students who discounted rate of $490. After January the handling, restraint, bleeding and successfully complete this course also 5 the registration fee increases to anesthetizing of laboratory animals is pass the Assistant Technician or the $540. Multiple discounts are available required. Through lectures, presenta- Technician certification test. College to registrants from the same company tions, and hands-on laboratory train- credit is not available to continuing or organization. Class size is limited, ing, participants will learn the princi- professional education students; how- so register early. For more informa- ples and practices of lab animal sci- ever, seven (7) Continuing Education tion, please call 732-932-9271, ext. ence with an emphasis on animal care Units (CEUs) and a certificate of com- 618. and various research techniques. pletion will be awarded. This is a semester-long, undergrad- The class meets Tuesday and
527 The Physiologist Announcements Vol. 45, No. 6, 2002
Albert Lasker Medical Research Awards
The major purpose of these Awards honorarium will be divided among the Award ($50,000): This Award honors is to recognize and honor individuals winners, and each will receive a stat- the scientist or scientists whose con- who have made significant contribu- uette and a citation. More than one tributions, directly or indirectly, have tions in basic or clinical research in scientist may be nominated if they led to the improvement of the clinical diseases that are the main cause of have worked as a team, or if they inde- management or treatment of patients death and disability. The Award win- pendently have made comparably con- and to the alleviation or elimination of ners may reside in any country of the tributions in their field. No more than one of the major medical causes of dis- world. three individuals will be considered ability or death. The Awards are intended to recog- for an Award in the basic or clinical Special Achievement Award in nize contributions that have opened category. Medical Science ($25,000): This new fields of research, advancing The Jurors’ evaluations of the con- Award honors a scientist whose contri- novel concepts or their applications in tributions of the nominees depend butions to research are of unique mag- a particular biomedical discipline. heavily on the information supplied in nitude and immeasurable influence on These advances may consist of a spe- the nomination forms. Therefore, the the course of science, health, or cific contribution or a long series of nomination should be accurate, medicine, and whose professional contributions that demonstrate the detailed, current and complete. career has engendered within the nominee’s significant leadership Supporting letters that specifically biomedical community the deepest towards the development of research address the nominee’s scientific feelings of awe and respect. (This concepts or their clinical application. accomplishments will be helpful to the Award will be given at the discretion Each Award consists of an honorari- Jury. of the Foundation in 2004). um, a citation and inscribed statuette Basic Medical Research Award Nomination forms are available at of the Winged Victory of Samothrace, ($50,000): This Award honors the sci- the Foundation’s website (http://www. symbolizing victory over death and entist or scientists who have made laskerfoundation.org) and should be disease. fundamental investigations that open received by the Foundation no later When the Award is given to more new areas of biomedical science. than February 3, 2003. ❖ than one individual in a category, the Clinical Medical Research
528 The Physiologist Announcements Vol. 45, No. 6, 2002
Arthur C. Guyton Physiology Educator of the Year Award
The Teaching Section of the Each nominee must be nominated teaching software; American Physiological Society invites by a member of APS. The nominator is authoring of textbooks; you to nominate a fellow physiology responsible for completing the applica- presentation and/or publication of educator for the Eleventh Annual tion materials and forwarding six (6) educational research; Arthur C. Guyton Physiology Educator copies of the application materials list- conducting seminars, workshops, of the Year Award. ed below to the Chairman of the conferences, etc. on physiology educa- Nominees must be full-time faculty Award Selection Committee, post- tion; members of accredited colleges or uni- marked no later than Friday A copy of the nominee’s curriculum versities and members of the APS. The December 13, 2002. vitae; Selection Committee will look for inde- Any additional documentation that pendent evidence of: 1) excellence in 1. A letter from the nominator would assist the selection committee classroom teaching over a number of 2. Letters of support from three other in evaluating the nominee’s contribu- years at undergraduate, graduate, or colleagues familiar with the nominee’s tion to physiology education. professional levels; 2) commitment to contributions to physiology education. The person selected will receive the the improvement of physiology teach- If possible, one letter should be from award during the APS business meet- ing within the candidate’s own institu- the nominee’s chairperson. One letter ing at the April 2003 annual meeting tion; and 3) contributions to physiolo- must be from a colleague outside of the of the American Physiological Society gy education at the local community, nominee’s institution (Experimental Biology 2003, April 11- national or international levels. 3. Letters of support from up to five 15 in San Diego, CA). The Arthur C. In the past, all nominees have current and/or former students Guyton Physiology Educator of the shown excellence in teaching at their 4. Scores on standard student evalua- Year will receive a framed, inscribed home institution and many have made tions (with normative data if possible) certificate, an honorarium of $1,000 significant local contributions through 5. Details of all teaching honors and expenses of up to $600 to attend advising, graduate education, or cur- received (i.e. Golden Apple, Teacher of the meeting. The awardee is requested riculum design and reform. Conse- the Year, etc.) to write an essay on his/her philosophy quently, the activities that distinguish 6. Evidence of education-related activ- of education for publication in The a candidate in the rankings include ities outside the classroom for which Physiologist. outreach activities at the state, nation- the nominee has achieved national or The Chairman of the Guyton Award al, or international level; contributions international reputation. This could Selection Committee is Michael to education through APS activities; include (but is not limited to): Levitzky, Department of Physiology peer-reviewed educational journal publication of teaching innovations Box P7-3, LSU Health Sciences articles; and widely disseminated pub- or educational research; Center, 1901 Perdido Street, New lications such as commercially pro- development and publication of lab- Orleans, LA 70112-1393. Tel: 504-568- duced textbooks, lab manuals, or soft- oratory exercises; 6184; Fax: 504-568-6158; Email: mle- ware. development and distribution of [email protected]. ❖
Gift Planning Opportunities The American Physiological Society Immediate Gifts: Cash, gifts of honor or memorialize an individual is pleased to invite the membership appreciated securities, gifts of closely or an organization and can include to consider including the APS in their held stock, gifts of tangible personal scholarships, programs, etc., which gift giving plans. Over the last sever- property, retirement assets, charita- are specified for support and named al years, the Society has received ble lead trusts and gifts of real estate. for individuals. donations of land and securities, all of Life Income Gifts: Gift annuities, Gifts by Will: Bequests of a per- which have been used to launch the deferred payment gift annuities, centage of estate, stated dollar Society’s various young investigator charitable remainder trusts, charita- amount or specific property or assets. award programs. ble remainder unitrusts, and charita- For more information on gift giving Many options exist if you are inter- ble annuity trusts. to the APS, please contact Martin ested in including the APS and its Gifts of Insurance: Ownership of Frank, Executive Director (Tel.: 301- Endowment Fund in your financial or life insurance policies can be donated, 530-7118, Email: mfrank@ estate planning. Some options or the APS can become the beneficia- the-aps.org), or Robert Price, Director include: ry of policies owned by others. of Finance (Tel.: 301-530-7173, Email: Designated Gifts: Gifts given to [email protected]).
529 The Physiologist Scientific Meetings & Congresses Vol. 45, No. 6, 2002
February 1-5 April 9-11 The 2003 Miami Nature Biotechnology Winter 4th International Symposium on Agmatine and Symposium: 50 Years On: From the Double Helix to Imidazoline Systems, San Diego, CA. Information: John Molecular Medicine, Miami Beach, FL. Information: E. Piletz, Depts. of Psychiatry, Pharmacology & Physiology, MNBWS, 1011 N.W. 15 St., Rm. 315, Gautier Bldg., Miami, University of Mississippi Medical Center, 2500 North State FL 33136-1019. Fax: 305-324-5665; Internet: http://www. St., Jackson, MS 39216-4505 USA. Email: AISymposium@ med.miami.edu/mnbws. psychiatry.umsmed.edu; Internet: http://aisymposium. aacdp.org/. February 2-7 Sixth International Congress of Comparative May 13-17 Physiology and Biochemistry, Mount Buller Village, The 30th Annual Meeting of the International Australia. Information: Abstract deadline and Early Bird Society for the Study of the Lumbar Spine, Registration deadline are September 30, 2002. Email: Vancouver, Canada. Information: Secretary, Dr. Scott [email protected]; Internet: http://www.zoo.Latrobe. Bodes, Sunnybrook and Women’s Health Science Center, edu.au/iccpb. Room MG 323, 2075 Bayview Ave., Toronto, Canada M4N 3M5. Tel: 416-480-4833; Fax: 416-480-6055. February 2-7 Gordon Research Conference on Salivary Glands May 28-31 and Exocrine Secretion, Ventura, CA. Information: Canadian Society for Pharmaceutical Sciences David Castle, Department of Cell Biology, University of Symposium, Delta Centre-Ville, Montreal, Quebec, Virginia Health System, School of Medicine, P.O. Box Canada. Information: Canadian Society for Pharmaceuti- 800732, Charlottesville, VA 22908-0732. Tel: 434-924-1786; cal Sciences, 3119 Dentistry/Pharmacy Centre, University Fax: 434-982-3912; Email: [email protected]; Internet: of Alberta Campus, Edmonton, Alberta, Canada, T6G 2N8. http://www.grc.uri.edu. Tel: 780-492-0950; Fax: 780-492-0951; Internet: http://www.ualberta.ca/~csps/. February 15-20 SPIE International Symposium Medical Imaging, June 2-5 Town and Country Hotel, San Diego, CA. Information: Eighteenth Annual Offering of Critical Issues in Internet: http://www.spie.org/info/mi. Tumor Microcirculation, Angiogenesis and Metasta- sis: Biological Significance and Clinical Relevance, February 19-22 Boston, MA Information: Internet: http://steele.mgh.har- 13th International Hypoxia Symposium, Banff vard.edu. Mountain Centre, Banff, Alberta, Canada. Information: http://www.hypoxia.net. June 8-12 The Joint Meeting of the 13th Annual Meetings of February 23-25 the American Summer Neuropeptide Conference & The Art of Grantsmanship—George Mason The European Neuropeptide Club (ENC), Montauk, University, Washington, DC. Information: Lisa Driver, NY. Information: Orit Khafi, Neuropeptides Conference Meetings Manager, The Council on Undergraduate Secretariat, P.O. Box 3190, Tel Aviv 61031, Israel. Tel: 972 Research, 734 15th Street, NW, Suite 550, Washington, DC 3 520 99 99; Fax: 972 3 523 92 99; Email: meetings@uni- 20005. Tel: 202-783-4810; Fax: 202-783-4811, Internet: tours.co.il. http://www.cur.org/03CURDialogues/03CURDialgues.htm. June 28-July 3 March 1-5 3rd Congress of the Federation of European Biophysical Society 47th Annual Meeting, San Physiological Societies, Nice, France. Information: Antonio, TX. Information: Biophysical Society, 9650 Sophia Antipolis, Faculte des Sciences, 06108 Nice Cedex2, Rockville Pike, Bethesda, MD 20814; Tel: 301-530-7114; France. Tel: +33 4 92076851; Fax: + 33 4 92076850; Email: Fax: 301-530-7133; Email: [email protected]; Internet: [email protected]; Internet: http://www.unice.fr/FEPS2003/. http://www.biophysics.org. June 29-July 4 March 12-16 International Society for Developmental and The National Comprehensive Cancer Network’s 8th Comparative Immunology (ISDCI) - 9th Annual Conference: Practice Guidelines and International Congress, St. Andrews, Scotland. Outcomes Data in Oncology, Hollywood, FL. Information: Dr. Val Smith or Mrs. Jane Williamson, Gatty Information: National Comprehensive Cancer Network, 50 Marine Laboratory, School of Biology, University of St. Huntingdon Pike, Suite 200, Rockledge, PA 19046. Tel: 215- Andrews, Fife KY 16 8LB. Email: [email protected] or 728-0862; Fax: 215-728-3877; Internet: http://www.nccn.org. [email protected]; Internet: http://www.st-and.ac.uk/~seeb/ ISDCI/home.htm.
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