SSX4 Antibody Cat. No.: 56-923

SSX4 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This SSX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 63-91 amino acids from the Central region of human SSX4.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 22 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

September 25, 2021 1 https://www.prosci-inc.com/ssx4-antibody-56-923.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: SSX4

ALTERNATE NAMES: Protein SSX4, Cancer/testis antigen 54, CT54, SSX4, SSX4A

ACCESSION NO.: O60224

GENE ID: 548313, 6759

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The product of this belongs to the family of highly homologous X (SSX) breakpoint . These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 have been involved in the t(X;18) BACKGROUND: translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.

REFERENCES: 1) Ayyoub, M., et al. J. Immunol. 174(8):5092-5099(2005)

2) Ross, M.T., et al. Nature 434(7031):325-337(2005)

3) Gure, A.O., et al. Int. J. Cancer 101(5):448-453(2002)

4) Brodin, B., et al. Gene 268 (1-2), 173-182 (2001) :

ANTIBODIES FOR RESEARCH USE ONLY.

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