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Effect of Gymnema Sylvestre R. Br. Leaves Extract on Certain

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Effect of Gymnema Sylvestre R. Br. Leaves Extract on Certain Journal of King Saud University – Science (2013) 25, 135–141 King Saud University Journal of King Saud University – Science www.ksu.edu.sa www.sciencedirect.com ORIGINAL ARTICLE Effect of Gymnema sylvestre R. Br. leaves extract on certain physiological parameters of diabetic rats Aziza A.M. El Shafey, Magda M. El-Ezabi, Moshira M.E. Seliem, Hannen H.M. Ouda, Doaa S. Ibrahim * Department of Zoology, Faculty of Science, Benha University, Egypt Received 29 June 2012; accepted 5 November 2012 Available online 16 November 2012 KEYWORDS Abstract Gymnema sylvestre R. Br. (G. sylvestre) belonging to the family Asclepiadaceae, has been Diabetes mellitus; used as a traditional medicine plant in Africa, Australia and Asia especially in India. Streptozotocin; Aim of the study: The present study aimed to clarify the effect of G. sylvestre leaves extract on Gymnema sylvestre; several physiological parameters of diabetic rats. Plasma glucose; Materials and methods: G. sylvestre leaves extract (18 mg/kg body weight) was orally adminis- Plasma insulin; tered for 30 days to normal and streptozotocin (STZ) diabetic rats. Lipid profile; Results: STZ-diabetic rats exhibited a significant increase in plasma glucose, liver function Liver function enzymes; enzymes [alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST)], triglycer- Oxidative stress ides, total cholesterol, LDL-cholesterol malondialdehyde, catalase, reduced glutathione and a sig- nificant decrease in insulin, HDL-cholesterol and erythrocyte superoxide dismutase levels. Treatment diabetic rats with G. sylvestre leaves extract significantly decreased plasma glucose, ALT, AST, triglycerides, total cholesterol, LDL-cholesterol, malondialdehyde and significantly increased insulin, HDL-cholesterol and erythrocyte superoxide dismutase levels compared to untreated diabetic rats. Conclusion: It could be concluded that G. sylvestre leaves extract treated diabetic rats’ complica- tions including hyperglycemia, hypoinsulinemia, hyperlipidemia and oxidative stress. ª 2012 King Saud University. Production and hosting by Elsevier B.V. All rights reserved. * Corresponding author. Tel.: +2 01063410190; fax: +2 0133222578. 1. Introduction E-mail address: [email protected] (D.S. Ibrahim). Diabetes mellitus (DM) is a metabolic disorder characterized 1018-3647 ª 2012 King Saud University. Production and hosting by by hyperglycemia resulting from defective insulin secretion, Elsevier B.V. All rights reserved. resistance to insulin action or both (Jarald et al., 2008; Vasi Peer review under responsibility of King Saud University. and Austin, 2009; Khan et al., 2012). DM is a widespread doi:10.1016/j.jksus.2012.11.001 disease, associates with chronic micro- and macro-vascular complications (Goycheva et al., 2006; Ahmed et al., 2011; Aralelimath and Bhise, 2012). Total recovery from diabetes Production and hosting by Elsevier has not been reported up to now and this explains the intensive studies done on it. 136 A.A.M. El Shafey et al. Untreated diabetes leads to serious complications or even Common name: Gurmar, Gymnema, Gurmari, Gurmarbo- premature death. The treatment of diabetes mellitus is based oti, periploca of the woods, and meshasring. on insulin and/or oral hypoglycemic drugs (Daisy et al., Physicochemical properties: G. sylvestre leaves extract is 2009). These drugs act by various mechanisms to control the soluble in water and other polar solvents as it contains blood glucose level, but many side-effects have been reported monosaccharides. G. sylvestre leaves extract has an acidic (Patel et al., 2012). Therefore, there is considerable interest nature due to the presence of carboxylic groups. G. sylvestre in the field of medicinal plants due to their natural origin contains more than 20 triterpene saponins that form molec- and less side effects (Jarald et al., 2008). One of these medicinal ular complexes with proteins, lipids, sterols and tannins plants is Gymnema sylvestre (Gurmar), which means sugar kill- (Spasov et al., 2008). er (Najafi and Deokule, 2011). It is a wild plant that grows in the open forest in India, China, Indonesia, Japan, Malaysia, Sri Lanka, Vietnam, and South Africa (Gurav et al., 2007; 2.3. Induction of diabetes mellitus Spasov et al., 2008). The leaves of the plant in particular are used as antiviral, diuretic, antiallergic, hypoglycemic, hypolip- Diabetes mellitus was experimentally induced in rats previously idemic, antibiotic, in stomach pains and in rheumatism (Saneja fasted for 12 h by a single intraperitoneal dose (45 mg/kg body et al., 2010). weight) of streptozotocin dissolved in citrate buffer (pH 4.5). In Most studies on G. sylvestre leaves extract focused on its order to overcome the hypoglycemic coma that occurs within role as hypoglycemic medicinal plant, but the present study the first 24 h following STZ injection, animals were given 5% glu- demonstrates the effect of G. sylvestre leaves extract (18 mg/ cose solution instead of drinking water for 2 days until sustained kg body weight) on several etiological factors of STZ-diabetic hyperglycemia was established (Abdel-Moneim et al., 2002). rats including hyperglycemia, hypoinsulinemia, hyperlipidemia Three days after streptozotocin injection, rats were screened for and oxidative stress at the same time. blood glucose levels. Blood samples were withdrawn from the lat- eral tail vein and glucose concentration was measured from over- 2. Materials and methods night fasted animals (10–12 h). Rats having glucose ranging from 180 to 200 mg/dl were considered as mild diabetic and included in 2.1. Experimental animals the experiment according to (Abdel-Moneim et al., 2002). White male albino rats (Rattus norvegicus) weighing 2.4. Experiment design 200 ± 10 g were purchased from the Center of Laboratory animals, venoms & crude antisera production, Helwan, Cairo, Egypt. Animals were maintained under laboratory conditions Rats under study were classified into five groups (6 rats each): [temperature (20 ± 2 C) and photoperiod (12 h light and 12 h dark cycle)]. Animals were allowed ad libitum to food Group I: normal rat group. and tap water. Rats were allowed to acclimatize for one week before the onset of the experiment. Rats of this group were given intragastrically 1 ml distilled water once a day for 30 days. 2.2. Diabetogenic agent and Gymnema sylvestre leaves extract Group II: rat group injected with citrate buffer. Streptozotocin (STZ) was purchased from Sigma Company (U.S.A) and given as a single intraperitoneal dose (45 mg/ Rats of this group were injected with a single intraperito- kg body weight) dissolved in citrate buffer (pH 4.5) accord- neal dose of 1 ml citrate buffer (pH 4.5). ing to El-Seifi et al. (1993). Gymnema sylvestre (G. sylvestre) leaves extract is used as Group III: rat group supplemented with G. sylvestre leaves drug called (Diaglu), that is produced by Arab Company extract. for Pharmaceuticals and Medicinal Plants (MEPACO) Enshas El Raml, Sharkeiya, Egypt. Diaglu contains G. syl- Rats of this group were supplemented with G. sylvestre vestre leaves extract only. G. sylvestre leaves extract was leaves extract (18 mg/kg b.w.) dissolved in 1 ml distilled water given in a dose of (18 mg/kg body weight) dissolved in once a day for 30 days. 1 ml distilled water according to Paget and Barnes (1964). Kirtikar and Basu (1998) classified G. sylvestre as the Group IV: STZ-diabetic rat group. following: Rats of this group were injected intraperitoneally with a single dose (45 mg/kg b.w.) of STZ dissolved in citrate buffer (pH 4.5). Kingdom Plantae Subkingdom Tracheobionta The diabetic rats were housed at the experimental condition Super division Spermatophyta for 30 days. Division Magnoliophyta Class Magnoliopsida Group V: rat group treated with G. sylvestre leaves extract Subclass Asteridae post STZ-diabetic induction. Order Gentianales Family Asclepiadaceae Rats of this group were treated intragastrically with G. Genus Gymnema sylvestre leaves extract (18 mg/kg b.w.) dissolved in 1 ml dis- Species sylvestre R. Br. Effect of Gymnema sylvestre R. Br. leaves extract on certain physiological parameters of diabetic rats 137 tilled water once a day for 30 days after STZ-diabetic III) compared to those of control rat groups (groups I and II, induction. respectively). On the other hand, plasma glucose levels were significantly high in the diabetic rat group (group IV) and 2.5. Blood sampling the rat group treated with G. sylvestre leaves extract post dia- betic induction (group V) in relation to those of control rat At the end of the experimental period, animals of each group groups. Plasma glucose level decreased significantly in group were fasted about 12 h and then anesthetized by diethyl ether V compared to that of group IV (Table 1). inhalation (Sinet et al., 1984). Blood samples were collected Plasma insulin level was significantly high (p < 0.05) in from post caval vein and directly transported to tubes contain- group III compared to those of groups I and II. On the other ing ethylenediamine tetra-acetic acid (EDTA) (El-Gomhorya hand, plasma insulin levels were significantly low in groups IV Co. Egypt). All the tubes were centrifuged at 3000 rpm. for and V compared to those of groups I and II. Plasma insulin 15 min by HittechÒ centrifuge and plasma free of hemolysis level increased significantly in group V compared to that of was separated and frozen at À20 °C for the determination of group IV (Table 1). physiological parameters. Packed erythrocytes were washed four times with isotonic solution (0.9% NaCl) and centrifuged Effect of G. sylvestre leaves extract on plasma liver function for 10 min at 3000 rpm. after each wash to remove the leftover enzymes level. leukocytes. After the last wash erythrocytes were frozen at À20 °C for the determination of superoxide dismutase level. Both plasma alanine aminotransaminase (ALT) and aspar- tate aminotransaminase (AST) levels in group III showed a 2.6. Determination of biochemical parameters non significant difference (p < 0.05) in relation to those of groups I and II. Plasma ALT and AST levels were significantly high in groups IV and V compared to those of groups I and II.
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