Phosphatidyl Serine Plus DHA with Serinaid®

Phosphatidyl serine plus DHA with SerinAid®

EXTENDED BENEFITS

Phosphatidylserine plus DHA helps support healthy cognitive function* Cognitive decline has emerged in the last 20 years as a major challenge to health systems affecting the quality of life of the aging population and of the social and economic environment of the patients and families. To cope with the risk of mood and cognitive decline, diet is one option that may contribute to the amelioration of neurodegenerative states. Among the dietary nutrients associated with the optimal development and function of the brain are docosahexaenoic acid (DHA) and phosphatidylserine (PS).* DHA appears to have a key role in neuronal phospholipid synthesis. In the brain, through the action of some specific enzymes, DHA metabolism generates phosphatidic acid, a precursor of phosphatidylserine, one of the most abundant phospholipids in brain cells.18 Both PS and DHA may help promote executive memory, learning, and mental processing.*19,20,21

Phosphatidylserine plus DHA helps support mood health, memory and attention abilities* Studies of phosphatidylserine dosing in age-associated memory INGREDIENTS impairment point to PS as an effective alternative option for memory The aging population results in an increased prevalence of diminished complaints among elderly individuals.*8,22 DHA and PS have been also cognitive functioning. Because aging is associated with changes in lipid studied for their key roles in supporting mood and memory health in composition in the brain, supplementation with phospholipids, which animals and humans.23,24,25,26 are fundamental components of neuron cell membranes, has been suggested for supporting healthy cognitive functions.*1,2 The history of PS and DHA have been also studied for their promising activities on phosphatidylserine (PS) began in 1940’s with its identification by Folch and supporting attention ability in children and adults.*27,28 its clinical use for the management of the aging brain.3,4

Doctor’s Best Phosphatidylserine plus DHA contains SerinAid® Phosphatidylserine (PS) and vegan-sourced DHA and has been shown to Supplement Facts help support cognitive function.*5 Numerous studies have demonstrated Serving Size 1 veggie softgel that PS could be beneficial for cognitive function, primarily those that are Servings per container 60 servings prone to worsen with age including memory, normal daily tasks, vocabulary skills, mood and attention health.*6,7,8 Together PS and DHA help facilitate Amount per serving % Daily Value the electric signals that are the basis of neuron communication, supporting not only cognitive function but also stress control.*9,10,11,12,13 DHA (Docosahexaenoic Acid, Omega-3 100 mg † from algae of Schizochytrium sp.) Phosphatidylserine (PS) has two FDA qualified health claims related to cognitive function – one is “phosphatidylserine may reduce the risk of Phosphatidylserine (PS, from SerinAid®) 100 mg † cognitive dysfunction in the elderly”* and the other one is “consumption of phosphatidylserine may reduce the risk of dementia in the elderly*.”14 † Daily Value not established.

The FDA has designated both phosphatidylserine (PS) and docosahexaenoic Other Ingredients: Soy lecithin, Veggie Softgel Acid, Omega-3 (DHA) as Generally Recognized As Safe (GRAS) meaning that these products are considered safe for human consumption.15,16,17 Contains Soy BENEFITS Suggested Adult Use: Take 1 softgel daily with food, or as recommended by a nutritionally-informed physician. ● Phosphatidylserine plus DHA helps support mood, learning, attention and other cognitive functions.* Gluten Free / Vegan ● Phosphatidylserine plus DHA helps support mood health, memory and attention abilities* Store in a cool dry place. ● Phosphatidylserine plus DHA helps support the body during SerinAid® is a registered trademark of Chemi Nutra. mental and physical stress* ● Non-GMO, Gluten Free, Vegan * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Phosphatidylserine plus DHA helps support the body be safe. They concluded that PS-DHA during mental and physical stress* may improve cognitive performance in the elderly population with memory Positive adaptations from training only occur when restoration exceeds 2 the catabolic dosage received during physical (and/or mental) training. complaints.* These results were also Many factors affect recovery after physical activities, such as additional found when the same research team stress. Accumulative stress can negatively affect restoration, as well conducted an open-label extension 29 aiming at evaluating the effect of PS- as performance. Phosphatidylserine (PS), has shown some positive 42 properties on recovery and human performance, and has also been shown DHA at a lower dosage.* to enhance mood, decision making and accuracy. Athletic performance is A pilot study evaluated the efficacy and safety of soybean-derived affected by several factors, in which PS might be able to help support the phosphatidylserine (SB-PS) in improving cognitive performance in the body during mental and physical stress.* 30,31,32,33,34 elderly with memory complaints. The computerized test results showed that SB-PS supplementation significantly increased the memory PHARMACOLOGICAL & CLINICAL STUDIES recognition, memory recall, executive functions, and mental flexibility. The Experimental studies (in rats and aged dogs) evaluated the effects of study also suggested that SB-PS is safe for human consumption and may phosphatidylserine (PS) on cognitive function. Findings from these studies be a safe alternative to phosphatidylserine extracted from bovine cortex.*43 showed that PS may have a positive effect on mood and memory function in rats and aged dogs.*23,24,35 Researchers evaluated the safety profile of a phosphatidylserine (PS) preparation in the non-demented elderly with memory complaints. The A clinical study was conducted to evaluate the effects of phosphatidylserine efficacy study of this particular formulation indicated that PS-DHA may (PS) on cognitive function in 35 participants with mild memory problems improve cognitive deficits in non-demented elderly population.* The associated with aging. The results indicated an improvement in the treated results of this study indicated that consumption of PS-DHA at a dosage group compared to the placebo group. The study concluded that PS of 300 mg PS/day for 15 weeks, or 100 mg PS/day for 30 weeks, is safe, supplementation was beneficial in improving daily life activities.*36 well tolerated, and does not produce any negative effects in the tested parameters.44 The effects of phosphatidylserine (PS) on cognitive and behavioral symptoms were studied in a group of 10 elderly women with mood The aim of another study was to investigate the effect of phosphatidylserine complaints. Results indicated that PS induced consistent improvement of (PS) on the memory of humans and rats with memory problems. The mood symptoms, memory functions and behavior impairment.*37 study concluded that PS decreased cholinesterase, improved memory in subjects with memory complaints and rats with memory defiency.*45 To evaluate the effect of phosphatidylserine on cognitive function in the elderly population, a double-blind randomized study was conducted To evaluate the effect of PS and omega-3 fatty acid-containing supplement in 494 participants. Participants in the treated group received 300 mg/ on mood health, a pilot study was conducted in elderly participants. day for 6 months. Statistically significant improvements in the PS-group Results showed significant improvement in mood state in treated compared with placebo group were observed in behavioral and cognitive participants. This suggested that supplements containing PS-DHA could parameters. It was also demonstrated that PS was well tolerated during be a beneficial option for improving mood health and neuron function in the study.38 elderly individuals.*46

A placebo-controlled study looked at the effectiveness of PS in individuals The effects on mobility and cognition of a multinutrient supplement that with mild memory problems associated with aging. They were randomly contains 60 mg phosphatidylserine (PS), 1 g DHA and other nutrients, were given either placebo or 100 mg PS, three times daily. The benefits they assessed in postmenopausal women. Results showed significant positive found included enhancement of memory and name recall, learning, and effects on cognitive tests and mobility with improved habitual walking ability to concentrate compared to the placebo group.*4 The subjects speed. Researchers concluded that multinutrient supplementation with tolerated PS well and no side effects were reported. DHA and PS may play a key role in supporting mobility and cognition functions.* 47 An open-label study (both the health provider and subjects were aware of the supplement given) looked at the effects of PS derived from plant A study investigated the effects of soybean-derived phosphatidylserine sources on 15 people with mild memory problems associated with aging. (PS) on exercise capacity, neuro-endocrine function, and feeling states The study found that subjects performed significantly better on most during exhaustive intermittent exercise. This was the first study to report of the tests after supplementing with PS and some subjects reported improved exercise capacity following PS supplementation suggesting improvement of their memory in day-to-day tasks.*39 that PS could enhance physical activity and/or help with recovery after exercise.*48 A double-blind, randomized controlled study was conducted to evaluate the effects of soybean-derived phosphatidylserine (Soy-PS) on The activity of phosphatidylserine (PS) on the neuro-endocrine and neuro- cognitive functions among elderly Japanese participants with memory vegetative responses to physical stress was evaluated in healthy men who complaints. They concluded that Soy-PS was safe to take and that Soy-PS underwent different experiments while on a bicycle. The study concluded supplementation could improve the memory functions of the elderly with that acute administration of PS may partially counteract the adreno- memory complaints.*40 cortical activation induced by physical stress.*30

To evaluate the efficacy of phosphatidylserine (PS) containing omega-3 A study was performed to evaluate the effect of oral phosphatidylserine fatty acid (PS-omega-3) on improving memory abilities, a pilot study (PS) supplementation on golf performance in young golfers. Results was conducted in elderly volunteers with memory complaints. Results showed that PS supplementation significantly increased the number of showed that PS-omega-3 supplementation was effective in increasing the good ball flights and showed a trend towards improving perceived stress ability to recall words. The study concluded that the combination of PS- levels during teeing-off. The study concluded that PS supplementation omega-3 may have a favorable effect on memory in subjects with memory showed a statistically significant tendency to improve perceived stress complaints.*41 levels in golfers.*31

A single-center randomized double-blind placebo-controlled study * These statements have not been evaluated by the Food and Drug Administration. evaluated the effects of a combination of phosphatidylserine + DHA (PS- This product is not intended to diagnose, treat, cure or prevent any disease. DHA) on cognitive functions. The combination PS-DHA was found to A study investigated the effect of phosphatidylserine (PS) on cognition and SCIENTIFIC cortical activity after mental stress in healthy subjects. This study showed chronic supplementation of PS significantly decreased Beta-1 power in REFERENCES right hemispheric frontal brain regions before and after induced stress 1. McDaniel MA, Maier SF, Einstein GO. and that was connected to a more relaxed state compared to the control “Brain-Specific” Nutrients: A Memory group.*9 Cure? Psychological Science in the Public Interest. 2002;3:12-38. A study examined the influence of short-term supplementation with a 2. 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Kato-Kataoka A, Sakai M, Ebina R et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010;47:246-255. 41. Richter Y, Herzog Y, Cohen T et al. The effect of phosphatidylserine- containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010;5:313-316. 42. Vakhapova V, Cohen T, Richter Y et al. Phosphatidylserine Containing * These statements have not been evaluated by the Food and Drug Administration. Omega-3 Fatty Acids May Improve Memory Abilities in Non- This product is not intended to diagnose, treat, cure or prevent any disease. demented Elderly Individuals with Memory Complaints: Results from © Doctor’s Best, Inc. phone: 800-333-6977 • fax: 949-498-3952 • www.drbvitamins.com

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