Exploratory Neuroimmune Profiling Identifies CNS-Specific Alterations in COVID-19 Patients with Neurological Involvement
bioRxiv preprint doi: https://doi.org/10.1101/2020.09.11.293464; this version posted December 9, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement Authors: Eric Song1,†,*, Christopher M. Bartley2,3,4†, Ryan D. Chow5, Thomas T. Ngo3,4, Ruoyi Jiang1, Colin R. Zamecnik3,6, Ravi Dandekar3,6, Rita P. Loudermilk3,6, Yile Dai1, Feimei Liu1, Isobel A. Hawes3,6,7, Bonny D. Alvarenga3,6, Trung Huynh3,6, Lindsay McAlpine8, Nur-Taz Rahman9, Bertie Geng10, Jennifer Chiarella8, Benjamin Goldman-Israelow1,9, Chantal B.F. Vogels11, Nathan D. Grubaugh11, Arnau Casanovas-Massana11, Brett S. Phinney12, Michelle Salemi12, Jessa Alexander3,6, Juan A. Gallego13-15, Todd Lencz13-15, Hannah Walsh9, Carolina Lucas1, Jon Klein1, Tianyang Mao1, Jieun Oh1, Aaron Ring1, Serena Spudich8, Albert I. Ko10,11, Steven H. Kleinstein1,16,17, Joseph L. DeRisi18,19, Akiko Iwasaki1,20,21, Samuel J. Pleasure3,6,b Michael R. Wilson3,6, ‡,*, Shelli F. Farhadian8,10, ‡,* Affiliations: 1 Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. 2 Hanna H. Gray Fellow, Howard Hughes Medical Institute, Chevy Chase, MD, USA. 3 Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. 4 Department of Psychiatry, University of California, San Francisco, CA, USA. 5 Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
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