The Journal of

VOLUME242 PHARMACOLOGY SEPTEMBER 1987 NUMBER 3 AND EXPERIMENTAL THERAPEUTICS

CONTENTS

Neurochemical and Behavioral Effects of CorticotropinRe1easing Factor in the Ventral Tegmental Area of the Rat. Peter W. Kalivas, Patricia Duffy and L. Gregg Latimer 757 Regulation of Alpha. 1 Receptors and Alpha- 1-Stimulated Phosphoinositide Hydrolysis in Pri- mary Neuronal Cultures. Rueben A. Gonzales, Fulton T. Crews, Cohn Sumners and Mohan K. Raizada 764 Analysis of Putative Alpha- is Adrenoceptor Agonism by Sgd 101/75 in the Rat Anococcygeus Muscle. M. K. James and H. J. Leighton 772 Reinforcing and Subjective Effects of Several Anorectics in Normal Human Volunteers. L. D. Chait, E. H. Uhienhuth

and C. E. Johanson 777 Downloaded from Pharmacological Characterization of CGS 15943A: A Novel Nonxanthine Adenosine Antagonist. Geetha Ghai, John E. Francis, Michael Williams, Ronald A. Dotson, Marlene F. Hopkins, Donald T. Cote, Frank R. Goodman and Mark B. Zimmerman 784 Adenosine Mediates the Negative Chronotropic Action of Adenosine 5’-Triphosphate in the Canine Sinus Node. Amir Pelleg, Takao Mitsuoka, Eric L. Michelson and Hyman Menduke 791 Comparison of in Vitro Actions with Behavioral Effects of Antimuscarinic Agents. J. M. Witkin, R. K. Gordon and

P. K. Chiang 796 jpet.aspetjournals.org Discriminative Stimulus Properties of Dl and D2 Agonists in Rats. Jonathan B. Kamien, Leon I. Goldberg and William L. Woolverton 804 Diltiazem and Autoregulation of Canine Cerebral Blood Flow. William J. Pearce and John A. Bevan 812 Id 147,798: A Novel Diuretic Agent with Beta Adrenoceptor Blocking Activity. S. T. Kau, B. B. Howe, J. H.-Y. Li, L. H. Smith, J. R. Keddie, J. J. Barlow, R. E. Giles and M. E. Goldberg 818 Lung Prostaglandin H Synthase and Mixed-Function Oxidase Metabolism of Nicotine. Michael B. Mattammal, Vijaya M. Lakshmi, Terry V. Zenser and Bernard B. Davis 827 at ASPET Journals on September 25, 2021 Cytotoxicity of Oxidative Metabolites of Procainamide. Robert L. Rubin, Jack P. Uetrecht and Joyce E. Jones 833 Regulation of Alpha-i Receptor Density and Functional Responsiveness in Rat Brain. Ronald D. Johnson, P. Michael luvone and Kenneth P. Minneman 842 Characteristics of i-Methyl-4-(2’-Methylphenyl)-i,2,3,6-Tetrahydrodropyridine-Induced Neurotoxicity in the Mouse. Patricia K. Sonsalla, Stephen K. Youngster, M. Victoria Kindt and Richard E. Heikkila 850 Mitochondrial and Metabolic Toxicity of i-Methyl-4-(2’-Methylphenyl)- 1,2,3,6-Tetrahydropyridine. M. Victoria Kindt, Richard E. Heikkila and William J. Nicklas 858 In Vitro Vascular Relaxation by New Inotropic Agents: Relationship to Phosphodiesterase Inhibition and Cyclic

Nucleotides. Raymond F. Kauffman, Kathryn W. Schenck, Barbara G. Utterback, V. Gail Crowe and Marlene L. Cohen . 864 Characterization ofthe Vasoactive Intestinal Peptide Receptor in Rat Submandibular Gland: Radioligand Binding Assay in Membrane Preparations. John T. Turner and David B. Bylund 873 Al- and A2-Selective Adenosine Antagonist: In Vivo Characterization of Cardiovascular Effects. Gary Evoniuk, Kenneth A. Jacobson, Mah T. Shamim, John W. Daly and Richard J. Wurtman 882 In Rat Hippocampus, Somatostatin i4 and Muscarinic Receptor Ligands Modulate an Adenylate Cyclase Belonging to a Common Domain of the Receptor. Carola Eva and Erminio Costa 888 Potentiation of the in Vitro T-Dependent Antibody Response by the B Subunit of Cholera Toxin. Kerry S. Campbell and Albert E. Munson 895 Identification of A1 and A3 Adenosine Receptors in the Rat Spinal Cord. Jos#{233}Ignacio Choca, Herbert K. Proudlit and Richard D. Green 905 3,4-Methylenedioxymethamphetamine and 3,4-Methylenedioxyamphetamine Destroy Serotonin Terminals in Rat Brain: Quantification of Neurodegeneration by Measurement of [3HjParoxetine-Labeled Serotonin Uptake Sites. George Battaglia, S. Y. Yeh, Elizabeth O’Hearn, Mark E. Molliver, Michael J. Kuhar and Errol B. De Souza 911 Individual Differences in Responsiveness to Single and Repeated Amphetamine Administration: Behavioral Characteristics and Neurochemical Correlates. David S. Segal and Ronald Kuczenski 917 Selective Gastric Antilesion Properties of Rioprostil, a Prostaglandin E1 Analog, in Rats and Dogs. L. B. Katz, D. A. Shriver, A. J. Tobia and M. E. Rosenthale 927 Ca Utilization in the Constriction of Rat Aorta to Stimulation of Protein Kinase C by Phorbol Dibutyrate. Andrew T. Chiu, Jeffrey M. Bozarth, Mark S. Forsythe and Pieter B. M. W. M. Timmermans 934 Mechanisms Mediating the Positive Inotropic and Chronotropic Changes Induced by in the Anesthe- tized Dog. Alan S. Bass, Jai D. Kohli, Nathan Lubbers and Leon I. Goldberg 940 Relaxing Effects of i5-Lipoxygenase Products of Arachidonic Acid on Rat Aorta. P. Uotila, R. Vargas, B. Wroblewska, M. d’Alarcao, S. P. Matsuda, E. J. Corey, C. M. Cunard and P. W. Ramwell 945 Characterization of D-2 Dopamine Receptors in a Tumor of the Rat Anterior Pituitary Gland. Christopher Lin, Paul McGonigle and Perry B. Molinoff 950 Binding, Degradation and Presser Activity of Angiotensins II and III after Aminopeptidase Inhibition with Amastatin and Bestatin. Raymond H. Abhold, Margaret J. Sullivan, John W. Wright and Joseph W. Harding 957 Contents Continued on iv Contents continued from iii

Neurochemical Actions of Anesthetic Drugs on the ‘y-Aminobutyric Acid Receptor-Chloride Channel Complex. J. Pablo Huidobro-Toro, Virginia Bleck, Andrea M. Allan and R. Adron Harris 963 Effects of Fentanyl on Vasopressin Secretion in Human Subjects. Richard B. Weiskopf, Ian A. Reid, Dennis M. Fisher, Margot A. Holmes, Judith I. Rosen and Lenny C. Keil 970 Effects of A23187, Exogenous Phospholipase A2 and Exogenous Arachidonic Acid on Pulmonary Vascular Resistance in Isolated Rabbit Lung. Michael R. Littner, Gertrude M. Kazmi and Fred D. Lott 974 Solubiization with Digitonin Alters the Kinetics of Pirenzepine Binding to Muscarinic Receptors from Rat Forebrain and Heart. Jian-Xin Wang, Lin Mci, Henry I. Yamamura and William R. Roeske 981 Thermodynamic Analyses of Pirenzepine Binding to Membrane-Bound and Solubilized Muscarinic Receptors from Rat Forebrain and Heart. Lin Mei, Jian-Xin Wang, William R. Roeske and Henry T. Yamamura 991 Bupivacaine and Lidocaine Blockade of Calcium-Mediated Slow Action Potentials in Guinea Pig Ventricular Muscle. Dennis E. Coyle and Nicholas Sperelakis 1001 Selective Ganglionic Blockade of Vagal Inputs to inoatriaI and/or Atrioventricular Regions. Janis D. Fee, Walter C. Randall, Robert D. Wurster and Jeffrey L. Ardell 1006 Differential Effects of Phenobarbital on Ester and Ether Glucuronidation of Diflunisal in Rats. Jiunn H. Lin, 1-Wu Chen, Edgar H. Ulm and Daniel E. Duggan 1013 Characteristics and Distribution of Specific Binding Sites for Leukotriene C4 in Human Bronchi. Maurizio Civelli, Daniela Oliva, Maurizio Mezzetti and Simonetta Nicosia 1019 Downloaded from Comparative Analysis of Beta- 1 Adrenoceptor Agonist and Antagonist Potency and Selectivity of , and . Peter E. Hicks, Icilio Cavero, Philippe Manoury, Fran#{231}oise Lefevre-Borg and Salomon Z. Langer 1025

Effects of L-652,731 , a Platelet-Activating Factor (PAF) Receptor Antagonist, on PAF- and Complement-Induced Pulmonary Hypertension in Sheep. Barry W. Smallbone, Nancy E. Taylor and John W. D. McDonald 1035 Characterization of Dog Fat Cell Adrenoceptors: Variations in Alpha-2 and Beta Adrenergic Receptors Distri- bution According to the Extent of the Fat Deposits and the Anatomical Location. Mohammed Taouis, Michel Berlan, Paul Montastruc and Max Lafontan 1041 jpet.aspetjournals.org Diuretic Effect Induced by Intrarenal Infusion of Pinacidil in Anesthetized Dogs. Shiro Morimoto, Yasuo Matsumura, Yasuto Sasaki, Toshio Takakuwa and Masaaki Kageyama 1050 Interaction between Neuronal Uptake Inhibitors and Presynaptic Serotonin Autoreceptors in Rat Hypothalamic Slices: Comparison of K and Electrical Depolarization. Francesca Passarelli, Anne-Marie Gaizin and Salomon Z. Langer 1056 Adenosine Inhibits Immunoglobulin E-Dependent Histamine Secretion from Human Basophil Leukocytes by Two Independent Mechanisms. Philip J. Hughes, R. Christopher Benyon and Martin K. Church 1064 at ASPET Journals on September 25, 2021 Contribution of Substance P to Heat-Induced Edema in Rat Paw. Norifumi Yonehara, Tooru Shibutani and Reizo Inoki 1071 Pharmacological Analysis of the Cardiac Actions of Xamoterol, a Beta Adrenoceptor Antagonist with Partial Agonistic Activity, in Guinea Pig Heart: Evidence for Involvement of Adenylate Cyclase System in Its Actions. Yuichi Hattori, Ichiro Sakuma, Yasuo Nakao and Mono Kanno 1077 Impairment of the Extraneuronal 0-Methylating System of Isoproterenol by Stop-Flow Ischemia in the Perfused Rat Heart. Masafumi Inoue, Keijoh Hifumi, Kazuyoshi Kurahashi and Motohatsu Fujiwara 1086 Effects of (-)-Desmethoxyverapamil on Heart and Vascular Smooth Muscle. Hermann Nawrath and Manfred Raschack 1090 Effects of Ethanol on Electrophysiological Properties of Rat Skeletal Myotubes in Culture. Chaya Brodie and S. R. Sampson 1098 Effects of Chronic Ethanol Treatment on Membrane Potential, Its Electrogenic Pump Component and Na-K Pump Activity of Cultured Rat Skeletal Myotubes. Chaya Brodie and S. R. Sampson 1104 Inhibition of Ischemia-Induced Subcellular Redistribution of Lysosomal Enzymes in the Perfused Rat Heart by the Calcium Entry Blocker, Diltiazem. Kazuo Ichihara, Takashi Haneda, Sokichi Onodera and Yasushi Abiko 1109 Effect of Lidocaine on the Myocardial Acidosis Induced by Coronary Artery Occlusion in Dogs. Naomi Matsumura, Hisao Matsumura and Yasushi Abiko 1114 Palytoxin-Induced Contraction and Release of Prostaglandins and Norepinephrine in the Aorta. Hiromi Nagase and Hideaki Karaki 1120 Protective Effects of Bepridil on Calcium Injury of Anoxic Myocytes Isolated from Adult Rat Heart Ventricular Muscle. C. Cruz, A. Zaoui, G. Berson and A. Younes 1126 Inhibition of Mitchondrial fl-Oxidation of Fatty Acids by Pirprofen. Role in Microvesicular Steatosis Due to This Nonsteroidal Anti-Inflammatory Drug. Jean Geneve, Brigitte Hayat-Bonan, Gilles Labbe, Claude Degott, Philippe Letteron, Eric Freneaux, The Le Dinh, Dominique Larrey and Dominique Pessayre 1133 Beta-2 Adrenoceptor Control of the Venous Circulation in Intact Dogs. Richard W. Lee, Thomas E. Raya, Richard G. Gay, Marcey Olajos and Steven Goldman 1138 1,2,3,6-Tetrahydro- i-Methyl-4-(Methylpyrrol-2-yl)Pyridine: Studies on the Mechanism of Action of i-Methyl- 4-Phenyl-l,2,3,6-Tetrahydropyridine. Kevin T. Finnegan, Ian Irwin, Louis E. DeLanney, George A. Ricaurte and J. William Langston 1144 Effects of Serotonin1 and Serotonin2 Receptor Agonists and Antagonists on Blood Pressure, Heart Rate and Sympathetic Nerve Activity. Robert B. McCall, Binita N. Patel and Lorri T. Harris 1152 Index, Volume 242, July-September 1987 1160