組織學 Histology 台北醫學大學/解剖學科 教授：邱瑞珍 分機號碼：3261 電子郵件信箱：[email protected]

1 Special sense –

台北醫學大學/解剖學科 馮琮涵 副教授 分機3250 E-mail: [email protected]

2 學習目的

•希望同學知道視網膜之顯微構造 •希望同學知道眼瞼顯微結構

3 參考資料

• Junqueira's Basic Histology, twelfth edition, text and atlas, Anthony L. Mescher, McGraw-Hill Companies

4 Summary

• A) eye ball: – tunica fibrosa – and – tunica vasculosa—, ciliary process, – tunica interna— – – vitrous body • B) accessory structure: – – lacrimal gland

5 6 7 8 Eye

• Wall of eyeball: tunicatunica fibrosafibrosa – cornea and sclera tunicatunica vasculosavasculosa – , & iris tunicatunica nervosanervosa – retina & pigmented layer opticoptic nervenerve & oraora serrataserrata

• Contents: lens, aqueous humor &

9 10 Cornea cornea – transparent, avascular, sensory innervation (CN V1)

•• cornealcorneal epitheliumepithelium : non-cornified stratified squamous epi. •• BowmanBowman’’ss membranemembrane : basement membrane •• stromastroma : laminated collagen fibers; muco-polysaccharide matrix •• DescemetDescemet’’ss membranemembrane: basement membrane • endothelium

11 Cornea

12 Sclera

sclera – thick c.t. with parallel collagen fibers, insertion site of extrinsic eye muscles • Epi-scleral tissue: loose vascular c.t., attaches • stroma: parallel collagen fibers

Corneo-scleral junction (limbus): • , • canal of Schlemm (scleral venous sinus) 13 14 trabecular meshwork

15 Choroid choroid – soft and thin c.t. membrane • Supra-choroid layer : numerous elastic fibers and pigment cells •• vascularvascular layerlayer : pigment cells and vessels • choriodo-capillaris layer : rich in capillaries; nutrient retina •• BruchBruch’’ss membranemembrane (lamina vitrea) : collagen fibrils; support retina

16 17 ciliary body & iris ciliaryciliary bodybody – (aqueous humor) • ciliary epithelium (simple low columnar or cuboidal epi.) + ciliaryciliary musclemuscle (circular)(circular) irisiris – continuous with ciliary body () • pigmented epithelium • dilator pupillae muscles & sphincter pupillae muscles

18 19 20 • Ciliary processes

21 Aqueous humor circulation aqueous humor from capillary of ciliary body → posterior chamber → pupil → anterior chamber → canal of Schlemn → venous sinus

22 23 24 25 lens lens – biconvex crystalline surrounded by a lenslens capsulecapsule • anterior surface lies the lenslens epitheliumepithelium •• lenslens fibersfibers • attach to ciliary body by zonular fibers (suspensory ligaments)

26 27 28 Retina • pigmented epithelium • segment : rod cells (dim-light); cone cells (color) • external limiting membrane : junctional complex between visual cells and sustentacular (Muller) cells • : nucleus of visual cells • : synapes with dendrites of bipolar neurons • : cell body of bipolar neurons, horizontal & amacrine cells • : synaptic region • : multipolar ganglion cells • nerve fiber layer : axons of ganglion cells • : basal lamina

* macula lutea and * * = blind spot * 29 30 31 32 33 34 35 36 37 38 39 40 41 Accessory structures of the eye •• EyelidsEyelids – levator palpabrae superioris, tarsal plate, tasal glands and conjunctiva •• LacrimalLacrimal apparatusapparatus – lacrimal glands, lacrimal canal, lacrimal sac & nasolacrimal duct •• ExtrinsicExtrinsic eyeeye musclesmuscles – superior oblique (by CN IV) lateral rectus (by CN VI) superior rectus, inferior rectus, medial rectus & inferior oblique (by CN III)

42 43

44 Conjunctiva

45 Lacrimal gland

46 47 48