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Butyraldehyde Casrn: 123-72-8 Unii: H21352682a

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Butyraldehyde Casrn: 123-72-8 Unii: H21352682a BUTYRALDEHYDE CASRN: 123-72-8 UNII: H21352682A FULL RECORD DISPLAY Displays all fields in the record. For other data, click on the Table of Contents Human Health Effects: Human Toxicity Excerpts: /HUMAN EXPOSURE STUDIES/ Three Asian subjects who reported experiencing severe facial flushing in response to ethanol ingestion were subjects of patch testing to aliphatic alcohols and aldehydes. An aqueous suspension of 75% (v/v) of each alcohol and aldehyde was prepared and 25 uL was used to saturate ashless grade filter paper squares which were then placed on the forearm of each subject. Patches were covered with Parafilm and left in place for 5 minutes when the patches were removed and the area gently blotted. Sites showing erythema during the next 60 minutes were considered positive. All three subjects displayed positive responses to ethyl, propyl, butyl, and pentyl alcohols. Intense positive reactions, with variable amounts of edema, were observed for all the aldehydes tested (valeraldehyde as well as acetaldehyde, propionaldehyde, and butyraldehyde). [United Nations Environment Programme: Screening Information Data Sheets on n-Valeraldehyde (110-62-3) (October 2005) Available from, as of January 15, 2009: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html] **PEER REVIEWED** [United Nations Environment Programme: Screening Information Data Sheets on n­Valeraldehyde (110­62­3) (October 2005) Available from, as of January 15, 2009: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html] **PEER REVIEWED** /SIGNS AND SYMPTOMS/ May act as irritant, /SRP: CNS depressant/ ...[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 242] **PEER REVIEWED** [Budavari, S. (ed.). The Merck Index ­ Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 242] **PEER REVIEWED** /SIGNS AND SYMPTOMS/ May produce skin and eye burns after contact.[National Fire Protection Guide. Fire Protection Guide on Hazardous Materials. 10 th ed. Quincy, MA: National Fire Protection Association, 1991., p. 49-44] **PEER REVIEWED** [National Fire Protection Guide. Fire Protection Guide on Hazardous Materials. 10 th ed. Quincy, MA: National Fire Protection Association, 1991., p. 49­44] **PEER REVIEWED** /SIGNS AND SYMPTOMS/ Butyraldehyde is extremely destructive of tissues of the mucosal membranes and upper respiratory tract, as well as of tissues of the eyes and skin. Inhalation may be fatal as a result of spasm, inflammation, and edema of the larynx and bronchi, chemical pneumonia, and pulmonary edema. Signs and symptoms of overexposure are a burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Medical conditions might be aggravated by continuous exposure.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5:978] **PEER REVIEWED** [Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1­9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5:978] **PEER REVIEWED** /CASE REPORTS/ Butyraldehyde has been tested for irritant effect on human eyes at vapor concn in air such as might occur in smog, and has been found nonirritant. ... In six instances of industrial corneal injury from butyraldehyde recovery is said to have been prompt and complete.[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 165] **PEER REVIEWED** [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 165] **PEER REVIEWED** /EPIDEMIOLOGY STUDIES/ Exposure to butyraldehyde may be implicated in observed associations between the occurrence of respiratory epithelium cancer in workers and lung cancer associated with high-temperature cooking. However, coexposures with other more reactive aldehydes do not support a role for butyraldehyde acting alone.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5:978] **PEER REVIEWED** [Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1­9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5:978] **PEER REVIEWED** /GENOTOXICITY/ Butanal had no effect on the rate of sister chromatid exchange in human lymphocytes in vitro.[OBE G, BEEK B; DRUG ALCOHOL DEPEND 4 (1-2): 91 (1979)] **PEER REVIEWED** PubMed Abstract [OBE G, BEEK B; DRUG ALCOHOL DEPEND 4 (1­2): 91 (1979)] **PEER REVIEWED** PubMed Abstract /GENOTOXICITY/ ...It produces DNA strand breaks in DNA PM2 in conjunction with copper chloride, but not alone, and cross-links with proteins, inducing unscheduled DNA synthesis in rat hepatocytes, but not human hepatocytes. ...[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5:978] **PEER REVIEWED** [Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1­9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5:978] **PEER REVIEWED** /OTHER TOXICITY INFORMATION/ The saturated aldehydes by inhalation show decreasing toxicity with increasing chain length in the order acetaldehyde, propionaldehyde, isobutyraldehyde, n-butyraldehyde, n-valeraldehyde and isovaleraldehye.[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II- 186] **PEER REVIEWED** [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II­186] **PEER REVIEWED** Skin, Eye and Respiratory Irritations: Irritating to skin, eyes and respiratory system.[Fire Protection Guide to Hazardous Materials. 13 ed. Quincy, MA: National Fire Protection Association, 2002., p. 49-35] **PEER REVIEWED** [Fire Protection Guide to Hazardous Materials. 13 ed. Quincy, MA: National Fire Protection Association, 2002., p. 49­35] **PEER REVIEWED** ...Eye or skin contact may cause burns and possible permanent damage. High exposure can cause dizziness and lightheadedness. Higher exposures can cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death... Prolonged or repeated skin exposure may cause skin disorders.[Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A-H Norwich, NY: Noyes Publications, 2002., p. 428] **PEER REVIEWED** [Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A­H Norwich, NY: Noyes Publications, 2002., p. 428] **PEER REVIEWED** Medical Surveillance: Consider chest x-ray following acute overexposure.[Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A-H Norwich, NY: Noyes Publications, 2002., p. 428] **PEER REVIEWED** [Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A­H Norwich, NY: Noyes Publications, 2002., p. 428] **PEER REVIEWED** Probable Routes of Human Exposure: NIOSH (NOES Survey 1981-1983) has statistically estimated that 5,392 workers (950 of these were female) were potentially exposed to butyraldehyde in the US(1). Occupational exposure to butyraldehyde may occur through inhalation and dermal contact with this compound at workplaces where butyraldehyde is produced or used. Monitoring data indicate that the general population may be exposed to butyraldehyde via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with consumer products containing this compound(SRC).[(1) NIOSH; NOES. National Occupational Exposure Survey conducted from 1981-1983. Estimated numbers of employees potentially exposed to specific agents by 2-digit standard industrial classification (SIC). Available at http://www.cdc.gov/noes/ as of Feb 2009.] **PEER REVIEWED** [(1) NIOSH; NOES. National Occupational Exposure Survey conducted from 1981­1983. Estimated numbers of employees potentially exposed to specific agents by 2­digit standard industrial classification (SIC). Available at http://www.cdc.gov/noes/ as of Feb 2009.] **PEER REVIEWED** Butyraldehyde was found in 10 of 15 personal air samples at a mean concentration of 0.68 ppb from samples taken in Helsinki, tested May to Sep 1997(1).[(1) Jurvelin JA et al; J Air Waste Manage Assoc 53: 560-73 (2003)] **PEER REVIEWED** [(1) Jurvelin JA et al; J Air Waste Manage Assoc 53: 560­73 (2003)] **PEER REVIEWED** Body Burden: Butyraldehyde was detected not quantified in 6 of 12 samples of human milk collected from volunteers in Bayonne, NJ, Jersey City, NJ, Bridgeville, PA, and Baton Rouge, LA(1).[(1) Pellizzari ED et al; Bull Environ Contam Toxicol 28: 322-8 (1982)] **PEER REVIEWED** PubMed Abstract [(1) Pellizzari ED et al; Bull Environ Contam Toxicol 28: 322­8 (1982)] **PEER REVIEWED** PubMed Abstract Emergency Medical Treatment: Emergency Medical Treatment: EMT Copyright Disclaimer: The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. The use of the Truven Health Analytics Inc. products is at your sole risk. These products are provided "as is" and "as available" for use, without warranties of any kind, either express
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