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Abstract Book UMMCD-2017 Printed by : Cherub Digimax Delhi - 110 096 © Shaheed Rajguru College of Applied Sciences for Women, Delhi 2017 Every possilbe effort has been made to ensure that the information in this book is accurate. The publisher and author cannot accept responsibility for any errors or omissions however caused. No responsibility for loss/damage caused to any person as a result of the material in this publication can be accepted by the editor, publisher or the author. SRCASW, Delhi (ii) Message from Chairperson It’s a matter of great pride and honor that Department of Biomedical Science, Shaheed Rajguru College of Applied Sciences is hosting the DBT sponsored second National Conference on Understanding the mechanisms and Challenges of Complex Diseases (UMCCD-2017) on 24th-25th January, 2017. This conference is a unique opportunity for students to interact directly with the people from academic and industry world and also to gather information about what is on the frontiers of all time changing technology. Conferences like this play an imperative role in apprising the students to the latest research. A complex disease is one with features that complicate the detection of the disease’s contributing factors. Discovering a contributing factor and characterizing its contribution to a complex disease is a difficult undertaking, because the effect of any single factor may be obscured or confounded by other contributing factors. In this context understanding complex disease is urgent and important because these conditions impose a burden on our country. Life Sciences is at the forefront of research in the 21st century and there is no better way to provide useful insights into research problems than to have the students interact with the scientists who are actually engaged in it. A conference like this would achieve this objective and pave way for many more like this to come. I am sure that it would be an enriching experience for all. I wish this conference all the success and wish that Department of Biomedical Science would organize more such events in the years to come. Dr. Payal Mago Principal Shaheed Rajguru College of Applied Sciences for Women University of Delhi (iii) Message from Organising Committee It is a great pleasure to welcome all of you to Shaheed Rajguru College of Applied Sciences for Women, University of Delhi for the DBT sponsored 2nd National Conference on Understanding the Mechanism and Challenges of Complex Diseases (UMCCD-2017). We welcome warmly all of our invited speakers who have accepted our invitation to lecture despite busy schedules. We hope that this conference allows students to interact with eminent scientists from all over the country. This conference intends to serve as an interface and amalgamates the disciplines of genetics, molecular biology, biochemistry and therapeutics. It involves various research areas, including Genetic and molecular basis of complex diseases, targeted gene delivery, genetic manipulations and therapeutic applications. We have several interesting sessions which highlight the vast scope of research in life sciences. It is encouraging that we have received abstracts of good quality from students and faculty all over India. One of the aims of such conferences is that researchers from different backgrounds will come together and new collaborations will emerge. Ultimately we need to enthuse, encourage and train our younger colleagues and students who will be the scientists of tomorrow. It is our hope that rapid strides will be made in the understanding the mechanism of these complex diseases and the only way forward is through research. It is our sincere hope that the National Conference on Understanding the Mechanism and Challenges of Complex diseases will serve as a platform towards achieving these goals. We express our profound gratitude to our sponsors and to the University of Delhi for supporting our efforts. We welcome you to this conference and hope that it will be a pleasant experience for all of you. Organising Committee UMCCD-2017 (iv) National Conference on Understanding the Mechanism and Challenges of Complex Diseases (UMCCD-2017) 24th-25th January, 2017 T e c h n i c a l P r o g r a m m e 24th January, 2017 09:00 am to 10:00 am Registration 10:00 am to 11:30 am Inauguration Keynote Address by Professor Dr. Seyed Ehtesham Hasnain, Vice Chancellor, Jamia Hamdard University, Professor & Head, Jamia Hamdard — Institute of Molecular Medicine, Invited Professor, IIT Delhi 11:30 am to 12:00 pm High Tea Session I 12:00 pm to 01:30 pm Understanding the Mechanism of Complex Diseases-I Prof. K. Natrajan, Director, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi Dr. Anurag Agrawal, Scientist, CSIR — Institute of Genomics and Integrative Biology, Mall Road, Delhi 02:00 pm to 03:00 pm Lunch and Scientific Poster Display/Exhibition Session II 03:00 pm to 04:30 pm Scientific Paper Presentations (Young Scientists) and Panel Discussion (v) 25th January, 2017 10:15 am to 11:15 am Plenary Lecture by Prof. Chinmay K. Mukhopadhyay, Special Centre for Molecular Medicine, Jawaharlal Nehru University, Delhi 11:15 am to 11:45 am High Tea Session III 11:45 am to 02:00 pm Understanding theMechanism/Challenges of Complex Diseases-II Dr. Bishwajit Kundu, Associate Professor, School of Biological Sciences, IIT Delhi Dr. Sivaram Mylavarapu, Associate Professor, Regional Centre for Biotechnology Scientific Paper Presentations (Young Scientists) and Panel Discussion 02:00 pm to 02:30 pm Lunch and Scientific Poster display/exhibition Session IV 02:30 pm to 04:00 pm Challenges & Pharmacological Interventions in Complex Diseases Dr. Devesh Bhardwaj, Associate Vice President, Mankind Research Centre, Mankind Pharma Limited Prof. Kanury V. S. Rao, THSTI — National Chair & Head, Drug Discovery Research Centre 04:00 pm to 05:00 pm Valedictory Function and Certificate Distribution ❖ ❖ ❖ (vi) National Conference on Understanding the Mechanism and Challenges of Complex Diseases (UMCCD-2017) 24th-25th January, 2017 TABLE OF CONTENTS S. No. Title / Speakers / Authors Page Speakers’ Abstracts 1. Mycobacterium Tuberculosis, the TB Bacteriums, is able to .................................... 1 achieve “More from Less for More” to fool the Human Post Seyed E. Hasnain 2. How do you solve a Problem like Tuberculosis : The Immortals of the Lung .......... 2 Krishnamurthy Natarajan 3. Syndromes, Phenotypes and Endotypes : Delving Deeper into Asthma ................... 3 Anurag Agrawal 4. Leishmaniadonovani — The Master of Mining Iron ................................................. 4 Chinmay K. Mukhopadhyay 5. Insights of Amyloid Interaction Network and Designing .......................................... 5 Structure-based Anti-amyloidogenic Biomolecules Bishwajit Kundu 6. Motoring through Cell Division ................................................................................ 6 Sivaram V S Mylavarapu 7. Overcrowding of Biosimilars Space — A Case for Biosuperiors ............................. 7 Dr. Devesh Bhardwaj 8. Exploiting Systems-based Approaches for Drug Target Discovery .......................... 8 Kanury V.S. Rao (vii) S. No. Title / Speakers / Authors Page Oral Abstracts 9. Pharmacological Characterizationof Benzylpiperidine Derivatives ........................ 10 in the Management of Alzheimer’s Disease Associated Pathogenesis Poonam Meena, Apra Manral, Vishal Nemaysh, Vikas Saini, Fouzia Siraj, Pratibha Mehta Luthra, Manisha Tiwari 10. Pharmacological Evaluation of Novel 1-[4-substituted-piperazin-1-yl)- ................ 11 phenyl]-3-phenyl-urea as Potent Anticonvulsant and Antidepressant Agents Shikha and Manisha Tiwari 11. Animal Models for Biological Screening of Anti-Diabetic .................................... 12 Drugs : Clinical and Pathophysiological Significance Dr. Binita Angom, Dr. Prabhakar Maurya 12. Anti-aging Bioactive Peptide induced Hormetic Mechanism involving ................. 13 P38MAPK/ NFkB and Nrf2 pathways in aged Fibroblast Cells Naveen Kumar, SB Mada, Srinu Reddi, Radha Yadav, Rishika Vij, Savita Devi, Suman Kapila and Rajeev Kapila 13. Exploring Dual Inhibitory Role of Febrifugine Analogues against ........................ 14 Plasmodium utilizing Structure-based Virtual Screening and Molecular Dynamic Simulation Rajan Kumar Pandey, Aruna Narula, Manisha Naskar, Vijay Kumar Prajapati 14. Anti-diabetic Effect of Lactobacillius in ................................................................. 15 Streptozotocin induced Diabetic Rats RadhaYadav, Sunita Meena, Naveen Shiwal, Suman Kapila, Rajeev Kapila 15. Anti-obesity Potential of Galactomannans : Efficacy to Regulate ......................... 16 Fat Mass Accumulation and Energy Homeostasis M. Aswani, A.K Mohanty and R.K Sharma ❖ ❖ ❖ (viii) S. No. Title / Speakers / Authors Page Poster Abstracts P-1 Pharmacophore Modeling and Atom-based ............................................................ 18 3D-QSAR Analysis of Piperidine and Piperazine Derivatives as Acetylcholinesterase Inhibitors Poonam Meena, Shruti Shalini, Urmila Gahlot and Manisha Tiwari P-2 Effect of Homocysteinylation on Intrinsically Disordered Proteins ........................ 19 Mordhwaj, Sulekh Chandra, Vandana Singh and Laishram R. Singh P-3 Mtb Invasion : Crucial Interacting Partners............................................................. 20 Zille Anam, Kuhulika Bhalla, Dr. Anand Ranganathan P-4 Synthetic Fabrication of Gold Nanoparticles with Controlled ................................ 21 Shape, Size and Surface Functionality
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