Immunohistochemical Detection of WT1 Protein in a Variety of Cancer Cells
Modern Pathology (2006) 19, 804–814 & 2006 USCAP, Inc All rights reserved 0893-3952/06 $30.00 www.modernpathology.org Immunohistochemical detection of WT1 protein in a variety of cancer cells Shin-ichi Nakatsuka1, Yusuke Oji2, Tetsuya Horiuchi3, Takayoshi Kanda4, Michio Kitagawa5, Tamotsu Takeuchi6, Kiyoshi Kawano7, Yuko Kuwae8, Akira Yamauchi9, Meinoshin Okumura10, Yayoi Kitamura2, Yoshihiro Oka11, Ichiro Kawase11, Haruo Sugiyama12 and Katsuyuki Aozasa13 1Department of Clinical Laboratory, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan; 2Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 3Department of Surgery, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan; 4Department of Gynecology, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan; 5Department of Urology, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan; 6Department of Pathology, Kochi Medical School, Kohasu, Oko-cho, Nankoku City, Kochi, Japan; 7Department of Pathology, Osaka Rosai Hospital, Sakai, Osaka, Japan; 8Department of Pathology, Osaka Medical Center and Research Institute of Maternal and Child Health, Izumi, Osaka, Japan; 9Department of Cell Regulation, Faculty of Medicine, Kagawa University, Miki-cho, Kida-gun, Kagawa, Japan; 10Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 11Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 12Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan and 13Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan WT1 was first identified as a tumor suppressor involved in the development of Wilms’ tumor. Recently, oncogenic properties of WT1 have been demonstrated in various hematological malignancies and solid tumors.
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