Paul W. Stewart, Phd

Paul W. Stewart, PhD

PERSONAL Office: 3105G McGavran-Greenberg Hall, Department of Biostatistics, UNC-CH School of Public Health, Chapel Hill, NC 27514 / (919) 966-7276.

Birthday: February 2, 1953 in Rose Hill, NC.

Home: 104 Manchester Place, Chapel Hill, NC 27516 / (919) 967-2003.

Family: Dawn Stewart and children, Alan and Tana.

EDUCATION Ph.D. The University of North Carolina, Chapel Hill, 1977-1981. Biostatistics, supporting program in Epidemiology and Biomedical Engineering.

M.S. The University of North Carolina, Chapel Hill, 1975-1977. Statistics, with thesis on time-series models for digital analysis of human speech.

B.S. Furman University, Greenville, South Carolina, 1971-1975. Mathematics, with electives in the Medical Sciences and in Visual Arts.

MAJOR PROFESSIONAL INTERESTS Research, Collaboration, and Teaching Design and Analysis Strategies for Biomedical Research Analysis of Incomplete/Coarsened Longitudinal and Multivariate Data Linear and Nonlinear Statistical Models for Repeated Measures Clinical and Environmental Studies Statistical Computing for Analysis and Data Management

ACCADEMIC APPOINTMENTS 1999-present Research Associate Professor, UNC Biostatistics Department 1982-1998 Research Assistant Professor, UNC Biostatistics Department 1982-1982 Visiting Research Assistant Professor, UNC Biostatistics Department

PROFESSIONAL SOCIETIES American Statistical Association (ASA) Publication Officer of the ASA Section on Statistical Consulting (years 2007 and 2008) International Biometric Society Association of GCRC and CTSA Statisticians ([email protected]) Founder (2002) and member of the Association of CFAR Statisticians ([email protected])

HONORS AND DISTINCTIONS Delta Omega, The Honor Society for Public Health Professionals NIH Training Grant (graduate school) An Associate Editor of Pediatric Pulmonology US-EPA Scientific Achievement Award for Publication (1997)

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PUBLICATIONS

1. Dissertation

Stewart PW (1981). "Application Of A Bivariate T Distribution To Hypotheses Testing In Crossover Experiments," Doctoral Dissertation, UNC-CH, December 1981. Institute of Statistics Mimeo Series. The University of North Carolina, Chapel Hill, NC.

Stewart PW, Helms RW (1989). “Evaluating The Distribution Function Of A Bonferroni Test Statistic From A Type III Bivariate T Distribution,” J. Comm. Stat., A18, No.2, 461-478.

2. Books Muller KE and Stewart PW (2006) Linear Model Theory: Univariate, Multivariate, and Mixed Models, Wiley Interscience, NY. 410pp.

3. Refereed Book Chapters

Anderson JJB, Switzer BR, Stewart PW, Symons M (2004). “Nutritional Assessment: Analysis of Relationships Between Nutrient Factors and Bone Health.” Chapter 3 in Nutrition and Bone Health, Ed. by Michael F. Holick and Bess Dawson-Hughes.

Stewart PW (2000), “Estimation and Comparison of Growth and Dose-Response Curves in the Presence of Purposeful Censoring”. Book Chapter #10 in the Handbook of Statistics, Vol. 18: Bioenvironmental and Public Health Statistics, Sen PK and Rao (eds.). Elsevier Science Publishing Co., North-Holland / Elsevier, Amsterdam; New York. pp. 325-354.

Stamm JW, Disney JA, Beck JD, Weintraub JA, Stewart PW (1993). "The UNC Caries Risk Assessment Study: Final Results and Some Alternative Modeling Approaches," pages 210-234, in Cariology for the Nineties, edited by Bowen WH and Tabak LA. Rochester, New York: University of Rochester Press.

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6. Refereed Publications

6.1. Refereed Publications from the NIH–Funded DELTA Program

Hill AM, Stewart PW, Fung MK, Reed RG, Kris-Etherton PM, Ginsberg HN, Tracy RP, Pearson TA, Lefevre M, Elmer PJ, Ershow AG, for the DELTA Investigators (2009) “Monthly Hemostatic Factor Variability In Women And Men” Submitted to Metabolism. (DELTA #107B: Stewart PW, DELTA Investigator.)

Berglund L, Lefevre M, Ginsberg HN, Kris-Etherton PM, Elmer PJ, Stewart PW, Ershow A, Pearson TA, Dennis BH, Roheim PS, Ramakrishnan R, Reed R, Stewart K, Phillips KM; DELTA Investigators. (2007) "Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states." American Journal of Clinical Nutrition. 86(6):1611-1620. (DELTA #202: Stewart PW, DELTA Investigator.)

Reed R, Stewart PW, Kris-Etherton PM, Pearson T, for the DELTA Investigators (2000). “Effects of Menstrual Cycle on Lipids and Hemostasis.” Metabolism. 49: 1101-1105. (Acknowledgment: Szu-Yun Leu.) (DELTA #107: Stewart PW, DELTA Investigator.)

Yu-Poth S, Etherton TD, Reddy CC, Pearson TA, Reed R, Zhao G, Jonnalagadda S, Wan Y, Kris-Etherton PM, for the DELTA Investigators (2000) “Lowering Dietary Saturated Fat and Total Fat Reduces the Oxidative Susceptibility of LDL in Healthy Men and Women”. Journal of Nurtrition 130(29): 2228-2237. (DELTA #A03: Stewart PW, DELTA Investigator.)

Jonnalagadda SS, Mitchell DC, Smicklas-Wright H, Meaker KB, Van Heel N, Karmally W, Ershow AG, Kris- Etherton PM, for the DELTA Investigators (2000) “Accuracy of Energy Intake Data Estimated by a Multiple-Pass, 24-hour Dietary Recall Technique”. J of American Dietetic Association 100(3): 303-308. (DELTA #A02: Stewart PW, DELTA Investigator.)

Burglund L, Oliver E, Fontanez N, Holleran S, Matthews K, Roheim P, Ginsberg H, Ramakrishnan R, Lefevre M, for the DELTA Investigators (1999) “HDL-Subpopulation Patterns in Response to Reductions In Dietary Total and Saturated Fat Intakes in Healthy Subjects.” American Journal of Clinical Nutrition 70: 992-1000. (DELTA #119: Stewart PW, DELTA Investigator.)

Phillips K, Tarrago-Trani M, Stewart KK (1999) “Phytosterol content of experimental diets differing in fatty acid composition.” (acknowledgement to the DELTA Investigators.) Food Chemistry 64: 415-422. (DELTA #907: Stewart PW, DELTA Investigator.)

Dennis B, Champagne C, Ershow PA, Karmally W, Kris-Etherton PM, Phillips K, Stewart K, Stewart PW, Van Heel N, Wang CH, Windhauser M, Farhat-Wood A, for the DELTA Investigators (1998). "Diet Design for Multicenter Controlled Feeding Trials: DELTA I.” Journal of the American Dietetic Association. 1998; 98(7), 766-776. (DELTA #106: Stewart PW, DELTA Investigator.)

Ginsberg H, Dennis B, Elmer P, Ershow P, Lefevre M, Pearson T, Roheim P, Ramakrishnan R, Reed RG, Anderson N, Stewart K, Philllps K, Stewart PW, Kris-Etherton P, for the DELTA Investigators (1998), "Diet Effects on Lipids and Thrombogenic Activity: Effects of Reducing Dietary Total and Saturated Fat on Plasma Lipids and Lipoproteins". Arteriosclerosis, Thrombosis, and Vascular Biology, 1998; 18: 441-449. (DELTA #101: Stewart PW, DELTA Investigator.)

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( 6.1. Refereed Articles: NHLBI – DELTA Program Publications, continued )

Mustad VA, Etherton TD, Cooper AD, Mastro AM, Pearson TA, Jonnalagadda SS, Kris-Etherton PM, (1997) “Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men & women.” Journal of Food Lipids. 1997;18:459-468. (DELTA #A01: Stewart PW, DELTA Investigator.)

Phillips KM, Lugogo RD, Harris RF, Tarrago-Trani MT, Bailey JA, Stewart KK, (acknowledgement to DELTA Investigators.) (1997). “Direct determination of trans-Octadecenoic acid in diet composites using a combination of silver ion, high performance, liquid chromatography and capillary gas chromatography.” Journal of Food Lipids. 1997; 4(3): 173-188. (DELTA #907: Stewart PW, DELTA Investigator.)

Lefevre M, Ginsberg HN, Kris-Etherton PM, Elmer PJ, Stewart PW, Ershow A, Pearson TA, Roheim PS, Ramakrishnan R, Derr J, Gordon D, Reed R, for the DELTA Investigators (1997). “ApoE genotype does not predict lipid response to changes in dietary saturated fatty acids in a heterogeneous normolipidemic population.” Arteriosclerosis, Thrombosis, and Vascular Biology. 1997; 17: 2914-2923. (DELTA #104: Stewart PW, DELTA Investigator.)

Phillips KM, Lugogo RD, Harris RF, Tarrago-Trani MT, Bailey JA, Stewart KK, for the Delta Investigators (1997). “Direct determination of trans-Octadecenoic acid in diet composites using a combination of silver ion, high performance, liquid chromatography, and capillary gas chromatography.” Journal of Food Lipids. 1997; 4(3): 173-188. (DELTA #412: Stewart PW, DELTA Investigator.)

6.2. Refereed Statistical and Biomedical Publications (other than DELTA)

Submitted

Noah TL, Ivins SS, Abode KA, Stewart PW, Michelson PH, Harris WT, Henry MM, Leigh MW (2009) "A randomized, prospective comparison of the effects of inhaled vs. systemic antibiotics on lower airway inflammation in children with cystic fibrosis and pseudomonas aeruginosa infection." Submitted to Pediatric Pulmonology.

Stewart PW, Benignus V (2009) “Nonlinear models for summary dose-response data.” Submitted to Biometrics.

Sigounas DG, Stewart PW, Kilpatrick M, Bullitt E, Smith JK, Ewend MG (2009) “A New Measurement Criterion for Evaluation of Metastatic Brain Lesions.” Submitted to Journal of Clinical Oncology.

Edwards LJ, Muller KE, Gurka MJ, Stewart PW, (2008) “Finding the best linear mixed model for longitudinal data: a critical review.” In revision for Biometrics.

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( 6.2. Refereed Statistical and Biomedical Publications -- other than DELTA, continued)

Published or In Press

Van Rie A, Dow A, Mupuala A, Stewart PW (2009) “Neurodevelopmental trajectory of HIV-infected children accessing care in Kinshasa, Democratic Republic of Congo” AIDS, v: pp-pp. Accepted March 2009 and in press.

McDonnell W, Stewart PW, Smith M (2009) “Modification of a Human Ozone Exposure-Response Model and Evaluation of Its Performance in Predicting Mean Changes in FEV1 in Independent Data.” Inhalation Toxicology v:pp-pp. Accepted March 2009 and in press.

Rosen DL, Schoenbach VJ, Wohl DA, White BL, Stewart PW, Golin CE (2009) “An evaluation of HIV testing in a large southern prison system.” American Journal of Public Health, v: pp-pp. Accepted March 2009 and in press.

Rosen DL, Schoenbach VJ, Wohl DA, White BL, Stewart PW, Golin CE (2009) “Characteristics and behaviors associates with HIV infection in a large southern prison system.” Am Journal of Public Health, v: pp-pp. Accepted March 2009 and in press.

Fischer LM, daCosta KA, Kwock L, Stewart PW, Lu T-S*, Stabler SP, Allen RH, Zeisel SH (2007). Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 85(5): 1275-1285.

McDonnell WF, Stewart PW, Smith MV (2007). The temporal dynamics of ozone-induced FEV1 changes in humans: an exposure-response model. Inhalation Toxicology 19(6-7): 483-494.

Dumond JB, Yeh RF, Patterson KB, Corbett AH, Jung BH, Rezk NL, Bridges AS, Stewart PW, Cohen MS, Kashuba AD. (2007) Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis. AIDS 21(14): 1899-1907.

Pilcher CD, Joaki G, Hoffman IF, Martinson FEA, Mapanje C, Stewart PW, Powers KA, Galvin S, Chilongozi D, Gama S, Price MA, Fiscus SA, Cohen MS, for the UNC Project in Malawi (2007). "Amplified Transmission of HIV-1: Comparison of HIV-1 Concentrations in Semen and Blood During Acute and Chronic Infection" AIDS 20;21(13): 1723-1730.

Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart PW, Weissler MC, Shores CG. (2007) "Defining cancer cachexia in head and neck squamous cell carcinoma." Clinical Cancer Research. 13(22 Pt 1): 6561-6567.

Golin CE, Earp J, Tien H-C*, Stewart PW, Porter C, Howie L. (2006) A 2-arm, randomized, controlled trial of a motivational interviewing-based intervention to improve adherence to antiretroviral therapy (ART) among patients failing or initiating ART. J Acquired Immune Deficiency Syndrome. 42(1): 42-51.

Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC. (2006) Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA 296(1): 87-93. #1 on "50 Most Frequently Read Articles" accessed from the web site during July 2006.

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( 6.2. Refereed Articles: Statistical and Clinical Publications, continued )

Watkins PB, Kaplowitz N, Colucci SV, Stewart PW, Harris SC. (2006) Reply: Acetaminophen and Aminotransferase Elevations. JAMA 296(23): 2798-2799.

Edwards LJ, Stewart PW, MacDougall JE*, Helms RW. 2006. A method for Fitting Regression Splines with Varying Polynomial Order in the Linear Mixed Model. Statistics in Medicine, 25(3): 513-27.

Mouly SJ, Matheny C, Paine MF, Lambda Smith G, Lamba J, Lamba V, Pusek SN, Schuetz EG, Stewart PW, Watkins PB (2005). Variation in oral clearance of saquinavir is predicted by CPY3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5. Clinical Pharmacology Therapy, 78(6): 605-618. Napravnik S, Edwards D, Stewart PW, Stalzer B, Matteson E, Eron JJ Jr. (2005). HIV-1 Drug Resistance Evolution Among Patients on Potent Combination Antiretroviral Therapy with Detectable Viremia. Journal of Acquired Immune Deficiency Syndrome. 40:34-40.

Paine MF, Ludington SS, Chen M-L, Stewart PW, Huang S-M, Watkins PB (2005). Do Men and Women Differ in Proximal Small Intestinal CYP3A or P-Glygoprotein Expression? Drug Metabolism and Disposition 33: 426-433.

Wohl DA, Zeng D, Stewart PW, et al. (2005) Cytomegalovirus, Mortality and CMV End-Organ Disease Among Patients with AIDS Receiving Potent Antiretroviral Therapies. JAIDS vv: pp-pp.

Girdler SS, Maixner W, Naftel HA, Stewart PW, Moretz RL, Kathleen CL (2005) Cigarette Smoking, Stress- Induced Analgesia and Pain Perception in Men and Women. Pain vv: pp-pp.

Stephenson BL, Wohl DA, Golin CE, Tien H-C*, Stewart PW, Kaplan AH (2005) Effect of Release from Prison and Re-incarceration on the Viral Loads of HIV-infected individuals. Public Health Reports 120:84-88.

Esther CR, Henry MM, Molina PL, Leigh MW (2005) Nontuberculous mycobacterial infection in young children with cystic fibrosis. Pediatric Pulmonology 40: 39-44. (“The authors … thank Xiaoyan Wang* and Dr. Paul Stewart for statistical consultation”).

Wohl DA, Tien H-C, Busby M, Cunningham C, MacIntosh B, Naprovnic S, Danan E, Donovan K, Hossenipour M, Simpson RJ, Jr, (2005). Randomized study of the safety and efficacy of fish oil (omega-3 fatty acid) supplementation with dietary and exercise counseling for the treatment of antiretroviral therapy-associated hypertriglyceridemia. Clinical Infectious Diseases, 41: 1498-1504. (“We thank Paul W. Stewart, Xiaoyan Wang*, Tsui-Shan Lu*, …for their assistance…”)

Napravnik S, Edwards D, Stewart PW, Stalzer B, Matteson E, Eron JJ Jr. (2005). HIV-1 Drug Resistance Evolution Among Patients on Potent Combination Antiretroviral Therapy with Detectable Viremia. Journal of Acquired Immune Deficiency Syndromes. 40:34-40.

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( 6.2. Refereed Articles: Statistical and Clinical Publications, continued )

Paine MF, Ludington SS, Chen M-L, Stewart PW, Huang S-M, Watkins PB (2005). Do Men and Women Differ in Proximal Small Intestinal CYP3A or P-Glycoprotein Expression? Drug Metabolism and Disposition 33: 426-433.

Wohl DA, Zeng D, Stewart PW, Glomb N, Alcorn T, Jones S, Handy J, Fiscus S, Weinberg A, Gowda D, van der Horst C (2005) JAIDS 38(5): 538-544.

Girdler SS, Maixner W, Naftel HA, Stewart PW, Moretz RL, Kathleen CL (2005) Cigarette Smoking, Stress-Induced Analgesia and Pain Perception in Men and Women. Pain 114(3): 372-385. Stephenson BL, Wohl DA, Golin CE, Tien H-C*, Stewart PW, Kaplan AH (2005) Effect of Release from Prison and Re-incarceration on the Viral Loads of HIV-infected individuals. Public Health Reports 120:84-88.

Bowman, FD*, Sen PK, Stewart PW (2005 ????). Comparing Estimators for Latent Subgroups and Observable Post-baseline Strata. Communications in Statistics vv: pp-pp.

Bowman, FD*, Stewart PW, Sen PK, Helms RW (2004). Making Inferences about Projected Completors in Longitudinal Studies. Journal of Biopharmaceutical Statistics 14(4): 947-967.

Pilcher CD, Tien HC, Eron JJ, Vernazza PL, Leu S-Y, Stewart PW, Goh LE, Cohen MS (2004). Brief but Efficient: Acute HIV Infection and the Sexual Transmission of HIV. Journal of Infectious Disease. 189:1785-1792.

Shefali MK, Paine MF, Stewart PW, Watkins PB (2004) 6’7’-Dihydroxyberamottin Contributes to the Grapefruit Juice Effect. Clinical Pharmacology and Therapeutics 75: 569-579.

Jiroutek MR, Muller KE, Kupper LL, Stewart PW (2003). A New Method for Choosing Sample Size for Confidence Interval Based Inferences. Biometrics, 59: 580-590.

Givens RC, Lin YS, Dowling ALS, Thummel KE, Lamba JK, Schuetz EG, Stewart PW, Watkins PB (2003). CYP3A5 Genotype Predicts Renal CYP3A Activity and Blood Pressure in Healthy Adults. Journal of Applied Physiology. 95: 1297-1300.

Lindesmith L, Moe CL, Marionneau S, Ruvoen N, Jiang X, Lindblad L, Stewart PW, LePendu J, Baric R (2003). Human Susceptibility and Resistance to Norwalk Virus Infection. Nature Medicine 9, 548 - 553.

Hoffman IF, Martinson FEA, Stewart PW, Chilongozi1 DA, Leu S-Y, Kazembe PN, Banda T, Dzinyemba W, Joshi1 P, Cohen MS, Fiscus SA (2003). HIV-1 RNA in Breast Milk Components. Journal of Infectious Disease. 188: 1209-1212.

Davenport ML, Punyasavatsut N, Stewart PW, Gunther DF. Savendahl L. Sybert VP. (2002) Growth failure in early life: an important manifestation of Turner syndrome. Hormone Research. 57(5-6):157-64.

Quinlivan EB, Zhang C, Stewart PW, Komoltri C*, Davis MG, Wehbie RS (2002). Elevated Virus Loads Of Kaposi's Sarcoma-Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, But Elevated Levels Of Human Immunodeficiency Virus Type 1 Do Not. Journal of Infectious Diseases, 185(12):1736-44.

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( 6.2. Refereed Articles: Statistical and Clinical Publications, continued )

Edwards LJ, Stewart PW, Muller KE, Helms RW (2001) “Linear Equality Constraints in the General Linear Mixed Model.” Biometrics 57, 1185-1190.

Quinlivan EB, Wang RX, Stewart PW, Komoltri C*, Regamey N, Erb P, Vernazza PL (2001). “Longitudinal sero-reactivity to human herpesvirus 8 (KSHV) in the Swiss HIV Cohort 4.7 years before KS”. Journal of Medical Virology. 64;157-166.

Jere C, Cunliffe NA, Hoffman IF, Stewart PW, Kilaru K*, Boradhead RL, Molyneux ME, Hart CA, Fiscus FA (2001). “Plasma HIV Burden in Malawian Children Co-Infected with Rotavirus.” AIDS Vol. 15, No.11, 1439-1442. McDonnell WF, Stewart PW, Smith MV, Pan WK, Pan J (1999) “Ozone-induced Respiratory Symptoms: Exposure- Response Models and Association with Lung Function.” European Respiratory Journal, 14: 845-853.

Davenport ML, Punyasavatsut N, Gunther D, Savendahl L, Stewart PW (1999) Turner syndrome: a pattern of early growth failure. Acta Paediatr Suppl 88(433):118-21

Muhlebach MS, Stewart PW, Leigh MW, Noah TL (1999). “Inflammatory Responses to Bacteria in Young Cystic Fibrosis and Control Patients.” American Journal of Respiratory and Critical Care Medicine 160: 186-191.

Herman-Giddens ME, Kotch JB, Browne DC, Ruina E, Winsor JR, Jung JW, Stewart PW (1997). "Childbearing Patterns in a Cohort of Women Sexually Abused as Children", Journal of Interpersonal Violence. 1998; 13(4), 504-513.

McDonnell WF, Stewart PW, Andreoni S, Seal E Jr, Kehrl R, Horstman DH, Folinsbee LJ, Smith MB (1997) "Prediction of Ozone-induced FEV1 Changes: Effects of Concentration, Duration, and Ventilation.” American Journal of Respiratory and Critical Care Medicine, 1997; 156: 715-722.

Quinlivan, EB, Ye D, Wehbie RS, Stewart PW, Flepp M, Vernazza PI. "Kaposi's Sarcoma Patients in the Swiss HIV Cohort Study with and without Detectable Human Herpesvirus 8 in Peripheral Blood Mononuclear Cells", AIDS 1997; 11: 1893-1895.

Kotch JB, DuFort V, Stewart PW, Fieberg J, McMurry M, O’Brian S, Ngui EM, Brennan M (1997). "Injuries Among Children in Home and Out-of-Home Care", Journal of Injury Prevention. 1997; 3: 267-271.

Kotch JB, Browne DC, Ringwalt CL, DuFort V, Ruina E, Stewart PW, Jung JW (1997). "Stress, Social Support and Substantiated Maltreatment in the Second and Third Year of Life", Journal of Child Abuse and Neglect, 1997; 21: 1025-1037.

McDonnell WF, Stewart PW, Andreoni S, Smith MB (1995) "Proportion of Moderately Exercising Individuals Responding to Low-level, Multi-hour Ozone Exposure." American Journal of Respiratory and Critical Care Medicine, 152, 589-596.

Kotch JB, Browne DC, Ringwalt CL, Stewart PW, Ruina E, Holt K, Lowman B, JW Jung (1995). Risk of Child Abuse and Neglect in a Cohort of Low Income Children." Journal of Child Abuse and Neglect, 19, 1115-1130.

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( 6.2. Refereed Articles: Statistical and Clinical Publications, continued )

Henderson FH, Henry MM, Ivins SS, Morris R, Neebe EC, Leu S, Stewart PW (1995). "Correlates of Recurrent Wheezing in School Age Children" American Journal of Respiratory and Critical Care Medicine, 151, 1786-1793.

Hillis SD, Weigle K, Miranda CM, McCann M, Bender D, Stewart PW (1995). "Supplementary Feeding in Colombian Child-Care Centers and Growth Velocity," Pediatrics, 94, 1066-1069.

Margolis MQ, Hunt RJ, Vann WF, Stewart PW (1994). "Distribution of primary tooth caries in first-grade children from two nonfluoridated US communities." Pediatric Dentistry, 16, 200-205.

Henderson FH, Stewart PW, Voter KZ, Strope GL, Burchinal MR, Ivins SS, Morris R, Ou-Li Wang, Henry MM (1992). "Respiratory allergy and the relationship between early childhood lower respiratory illness experience and subsequent lung function" American Review of Respiratory Disease1, 145, 283-290

Strope G, Stewart PW, Henderson F, Henry M, (1991). "Respiratory allergy and the relationship between early childhood lower respiratory illness experience and subsequent lung function." American Review of Respiratory Disease1, 144, 655-662.

Stewart PW (1991), "Tracking Analysis for Inconsistently Timed Longitudinal Data," Presentation at the June '91 Symposium on Longitudinal Data Analysis, Two page abstract in Statistics in Medicine, 11, 2027-2040.

Stewart PW (1991). "The graphical advantages of finite interval confidence band procedures." Communication in Statistics, A20, No. 12, 3975-3994.

Stewart PW, Stamm JW, (1991). "Classification tree prediction of caries using clinical, Microbiological & Interview Data," Journal of Dental Research, 70(9), 1239-1251.

Stamm JW, Stewart PW, Bohannan HM, Disney JA, Graves RC, Abernathy JR (1991). "Risk Assessment for Oral Diseases," Advances in Dental Research, 5, 4-17.

Scruggs RR, Stewart PW, Samuels MS, Stamm JW (1991). "Clinical evaluation of seven anti-calculus dentifrice formulations," Journal of Clinical Periodontology, 13, 23-27.

Stewart PW, Helms RW (1989). "Evaluating the distribution function of a Bonferroni test statistic from a type III bivariate t distribution," Communications in Statistics, A18, No. 2, 461-478.

Stewart PW (1989). "Extension of the Harrell-Davis quantile estimator to finite populations," Communications in Statistics, A18, No. 3, 853-876.

Stamm JW, Disney JA, Graves R, Cancro L, Payonk G, Stewart PW (1988). "An Evaluation of six dentifrice formulations for anticalculus activity," Journal of Clinical Periodontology, 16, 101-111

1 American Journal of Respiratory and Critical Care Medicine was formerly known as American Review of Respiratory Disease.

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( 6.2. Refereed Articles: Statistical and Clinical Publications, continued )

Stewart PW (1987). "Line-segment confidence bands for repeated measures," Biometrics, 43, 629-640.

Voter K, Henry M, Stewart PW, Strope G, Henderson F, (1987). "Methacholine sensitivity and lung function related to pre-school lower respiratory illness in children in Chapel Hill, NC." American Review of Respiratory Disease1, 137, 302-307.

Carson JL, Collier AM, Hu SS, Smith CA, Stewart PW (1987). "The appearance of compound cilia in the nasal mucosa of normal human subjects following acute environmental exposure to sulfur dioxide. Environmental Research, 42, 155-165.

Glueck C, Laskarzewski P, Suchindran C, Chambless W, Stewart PW, Heiss H, Tyroler A (1986). "Progeny's lipid levels by parental mortality," Circulation. Part 2, 73, pp 51-61.

Kwiterovich P, Stewart PW, for the LRC Investigators (1986). "Detection of dyslipoproteinemia using plasma total cholesterol and triglyceride levels," Circulation, Part 2, 73, pp 30-39.

6.3. Refereed Publications with Acknowledgements to PW Stewart

Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. (2006) Mucus clearance and lung function in cystic fibrosis with hypertonic saline. New England Journal of Medicine. 354(3): 241-250. Acknowledgement to Dr. Stewart of analysis of the data.

Peck MD, Kessler M, Cairns BA, Chang Y-H, Ivanova A, Schooler W (2004). Early Enteral Nutrition Does Not Decrease Hypermetabolism Associated with Burn Injury. The Journal of Trauma Injury, Infection, and Critical Care. 57:1143-1149. “We thank… Paul Stewart, PhD, … for participation in study design….”

Paine MF, Wagner DA, Hoffmaster KA, Watkins PB (2002). Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin. Clinical Pharmacology and Therapeutics. 72: 524-535.

Carson JL, Collier AM, Gambling TM, Hu SC (1999) “An Autoradiographic Assessment of Epithelial Cell Proliferation and Post-Natal Maturation of the Tracheal Epithelium in Infant Ferrets. Anatomical Record. 256(3): 242-251. (“The authors gratefully acknowledge the helpful consultation of Dr. Paul Stewart of the Department of Biostatistics at the University of North Carolina at Chapel Hill with the statistical analyses of the morphometric data.")

Richards HB, M Satoh, JC Jennette, T Okano, YS Kanwar, and WH Reeves (1999). Disparate T cell requirements of two subsets of lupus-specific autoantibodies in pristane-treated mice. Clinical and Expperimental Immunology 115:547-553 (1999).

Smith, MV and McDonnell WF (1999) “A statistical model for FEV1 response to arbitrary dynamic ozone exposure conditions” J. Air and Waste Manage. Assoc. 1999, 49:289-298. (Acknowledgment: Stewart PW.)

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( 6.3. Refereed Publications with Acknowledgements to PW Stewart, continued )

McDonnell WF, Smith MV (1994). "Description of Acute Ozone Response as a Function of Exposure Rate and Total Inhaled Ozone." Journal of Applied Physiology, 76: 2776-2784.

Feinstein AR, Spitzer WO, (1987) An Editorial,"The Unknown Reviewer: An Expression of Policy and Gratitude", Journal of Chronic Diseases, 40:101-104. (Ack. on p. 104)

Kusy RP, Whitley JQ (1990). "Coefficients of friction for arch wires in stainless steel and polycrystalline alumina bracket slots", American Journal of Orthodontic Dentofacial Orthopedics, 98: 300-312.

Bader J, editor (1990). Proceedings of the Conference on Risk Assessment in Dentistry. (Acknowledgement of planning committee members for the conference.)

Little J, Graves K, Suchindran C for the LRC Investigators (1986). "Customary diet, anthropometry, and dyslipoproteinemia in selected North American populations," Circulation, Part 2, Vol. 73, No. 1, pp 80-90.

Rifkind BM for Lipid Research Clinics Program, NIH (1980). The Lipid Research Clinics Population Studies Data Book: Vol. I Prevalence Study. NIH Publication No. 80-1527, 136 page 10. (General acknowledgement of contributors.)

Zerbe GO, and Jones RH, (1980) "Application of Growth Curve Techniques to Time Series Data", JASA, Vol. 75, No. 371, pp 507-509. (Referee acknowledgement)

Haley RW for the SENIC Investigators (1980). Special Issue, "The SENIC Project" The American Journal of Epidemiology, Vol. 111, pp 465-653. (Acknowledgement of members of the UNC Department of Biostatistics who contributed to the project and manuscripts.)

6.4. Book Reviews

Review of "Time Series: A Biostatistical Introduction", Diggle PJ (Author); Stewart PW (Reviewer). JASA, 1992; 87: 255-255.

Review of "Linear Mixed Models in Practice: A SAS-oriented Approach", Verbeke G and Molenberghs G (Editors); Stewart PW (Reviewer). Technometrics, 1999; 41(1): 79-79.

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7. Other Published Articles

Stewart PW (1990), "Classification Tree Prediction of Caries Using Clinical, Microbiological and Interview Data," From a stenographer's verbatim transcript of Nov.'90 presentation to the Task Force on Design and Analysis (for Dental Research) Published in Transactions of The Task Force on Design & Analysis. Edited by Neal W. Chilton.

8. Monographs

8.1 Texts (not peer-reviewed)

Stewart PW (1977). “Some Properties of the Linear Prediction Estimator for the Power Spectrum of a Speech Wave: Original Results for Autoregressive Processes,” Master's Thesis, UNC-CH, Institute of Statistics Mimeo Series. The University of North Carolina, Chapel Hill, NC.

Stewart PW, “The Thrill of Theory: Foundations for the Joy of Modeling”, Lecture notes for BIO263, Advanced Linear Models Theory, 485 typed pages. Available from UNC Custom Publishing.

Stewart PW, “Matrix Results Useful in Statistics", Lecture notes for BIOS107 and BIOS108 one-hour review courses, 165 pages. Available from UNC Custom Publishing.

8.2 Electronic Publications (not peer-reviewed)

Stewart PW, “What is a Pilot Study?” http://www.cincinnatichildrens.org/research/cores/gcrc/protocols/Small_or_Pilot_Studies.htm

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COLLABORATION WITH STUDENTS

1. Current and Previous Doctoral Students in Collaborative Publications

Many of the more than 20 doctoral students who have worked collaboratively with Dr. Stewart have received recognition in collaborative publications. Examples of Dr. Stewart’s efforts to arrange and direct students in co- authorship are highlighted in bold face here.

Engmann C, Adanub R, Lu T-S, Bose C, Lozoff B (2008). Anemia and iron deficiency in pregnant Ghanaian women from urban areas, International Journal of Gynecology and Obstetrics, 101(1):62-66

Fischer LM, daCosta KA, Kwock L, Stewart PW, Lu T-S, Stabler SP, Allen RH, Zeisel SH (2007). Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition. 85(5):1275-1285.

Edwards LJ, Stewart PW, MacDougall JE, Helms HW (2006). A Method for Fitting Fixed-knot Regression Splines in the General Linear Mixed Model. Statistics in Medicine, 25(3): 513-527.

Esther CR, Henry MM, Molina PL, Leigh MW (2005) Nontuberculous mycobacterial infection in young children with cystic fibrosis. Pediatric Pulmonology 40: 39-44. (“The authors … thank Xiaoyan Wang and Dr. Paul Stewart for statistical consultation {supported by NIH CFAR grant P30-HD37260 and by NIH GCRC grant RR00046}”).

Wohl DA, Tien H-C, Busby M, Cunningham C, MacIntosh B, Naprovnic S, Danan E, Donovan K, Hossenipour M, Simpson RJ, Jr, (2005). Randomized study of the safety and efficacy of fish oil (omega-3 fatty acid) supplementation with dietary and exercise counseling for the treatment of antiretroviral therapy- associated hypertriglyceridemia. Clinical Infectious Diseases, 41: 1498-1504. (“We thank Paul W. Stewart, Xiaoyan Wang, Tsui-Shan Lu, …for their assistance…”)

Pilcher CD, Tien H-C, Eron JJ, Vernazza PL, Leu S-Y, Stewart PW, Goh LE, Cohen M (2004). Brief but Efficient: Acute HIV Infection and the Sexual Transmission of HIV. The Journal of Infectious Diseases. 189:1785-1792.

Stephenson BL, Wohl DA, Golin CE, Tien H-C, Stewart PW, Kaplan AH, (2005). Effect of Release from Prison and Re-incarceration on the Viral Loads of HIV-Infected Individuals. Public Health Reports, 120:84-88.

Lindesmith L, Moe CL, Marionneau S, Ruvoen N, Jiang X, Lindblad L, Stewart PW, LePendu J, Baric R (2003). Human Susceptibility and Resistance to Norwalk Virus Infection. Nature Medicine 9, 548 - 553.

Quinlivan EB, Zhang C, Stewart PW, Komoltri C, Davis MG, Wehbie RS (2002). Elevated Virus Loads Of Kaposi's Sarcoma-Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, But Elevated Levels Of Human Immunodeficiency Virus Type-I Do Not. Journal of Infectious Diseases, 185(12):1736-44, 2002.

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Elder DA. Roper MG. Henderson RC. Davenport ML. (2002) Kyphosis in a Turner syndrome population. Pediatrics. 109(6):e93. Acknowledgement to Stewart PW and Lindblad L.

DuFort V, Kotch J, Stewart PW, Harb M, McMurray M (1998), “Are home-care children different from out-of-home care children?” Proceedings of Fourth World Conference on Injury Prevention and Control, Amsterdam (May, 1998).

Kotch JB, DuFort V, Stewart PW, Fieberg J, McMurry M, O’Brian S, Ngui EM, Brennan M (1997). "Injuries Among Children in Home and Out-of-Home Care", Journal of Injury Prevention. 1997; 3: 267-271.

Herman-Giddens ME, Kotch JB, Browne DC, Ruina E, Winsor JR, Jung JW, Stewart PW (1998). "Childbearing Patterns in a Cohort of Women Sexually Abused as Children", Journal of Interpersonal Violence. 1998; 13(4), 504-513.

2 American Journal of Respiratory and Critical Care Medicine was formerly known as the Am. Rev. of Resp. Dis.

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2. Dissertation Research Directed by Dr. Stewart

Participation on doctoral committees is documented in the teaching portfolio. The following are selected examples of joint (Stewart – student) publications generated by dissertation research.

Enck SW, Stewart PW (2009). Latent Class Linear Mixed Models: A General Approach Implemented via SAS R Macro with a Tutorial for Clinical Researchers. To be submitted.

Bowman FD, Stewart PW, Sen PK, Helms RW (2004). Making Inferences about Projected Completors in Longitudinal Studies. Journal of Biopharmaceutical Statistics 14(4): 947-967.

Jiroutek MR, Muller KE, Kupper LL, Stewart PW (2003). A New Method for Choosing Sample Size for Confidence Interval-Based Inferences. Biometrics, 59: 580-590.

Hillis SD, Weigle K, Miranda CM, McCann M, Bender D, Stewart PW (1995). "Supplementary Feeding in Colombian Child-Care Centers and Growth Velocity," Pediatrics, 94, 1066-1069.

Margolis MQ, Hunt RJ, Vann WF, Stewart PW (1994). "Distribution of primary tooth caries in first-grade children from two nonfluoridated US communities." Pediatric Dentistry, 16, 200-205.

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PRESENTATIONS

1. Selected Original Research Presentations: Seminar Format

Stewart PW (2007), "Pilot Studies, Feasibility Studies, and Small Exploratory Studies" UNC Clinical Research Scholars (K30/K12), UNC School of Medicine, Chapel Hill, NC.

Stewart PW (2004), "Introduction to Power Analysis," UNC General Clinical Research Center(GCRC), Doris-Duke Research Fellows, UNC School of Medicine, Chapel Hill, NC.

Stewart PW (2002), "Introduction to Power Analysis," UNC General Clinical Research (GCRC), UNC School of Medicine, Chapel Hill, NC.

Stewart PW (1995), "Risk Modeling of EPA Clinical Research Branch Ozone Response Data," EPA - UNC Cooperative Agreement Program, U.S. EPA, Chapel Hill, NC.

Stewart PW (1995), "Longitudinal Analysis of Pulmonary Function for Cystic Fibrosis Patients," Biostatistics Dept., Genentech Inc., South San Francisco, CA.

Stewart PW (1995), "Longitudinal Analysis of Long-term Benefits of Pulmozyme (R) for Cystic Fibrosis Patients," Biostatistics Dept., Genentech Inc., S. San Francisco, CA.

Stewart PW (1993), "Simultaneous Confidence Bands for Non-Linear Longitudinal Models," Biostatistics Department, UNC, Chapel Hill, NC.

Stewart PW (1991), "Methods for Informatively Right-Censored Longitudinal Data," Biostatistics Department, UNC, Chapel Hill, NC.

Stewart PW (1991), "Methods for Right-Censored Longitudinal Data," Biostatistics Section, Bowman Gray School of Medicine, Winston-Salem, NC.

Stewart PW (1991), "Tree-Structured Models for Classification and Regression," Biostatistics Department, UNC, Chapel Hill, NC.

Stewart PW (1987), "Finite Interval Confidence Bands for Repeated Measures," Mathematics Department, East Carolina University, Greenville, NC.

Stewart PW (1985), "Finite Interval Confidence Bands for Repeated Measures," Biostatistics Department, Glaxo, Inc.

Stewart PW (1985), "Finite Interval Confidence Bands for Repeated Measures," Biometrics Department, Medical University of South Carolina.

Stewart PW (1985), "Finite Interval Confidence Bands for Repeated Measures," Statistics Department, University of Florida, Gainsville, FL.

Stewart PW (1985), "Finite Interval Confidence Bands for Repeated Measures," Biostatistics Department, Vanderbilt University, TN.

Stewart PW (1985), "Finite Interval Confidence Bands for Repeated Measures," Biostatistics Department, Emory University, Atlanta, GA.

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2. Selected Original Research Presentations: Statistical Research

Stewart PW (2008) “Directing Biostatistics Cores in Biomedical Research.” Invited session at the Joint Statistical Meetings, Denver, CO. August 2008.

Stewart PW (2006) “A Bernoulli / Left-Censored Lognormal Mixture Model for Activity of the Protease of HIV-1 as a Function of Amino Acid Characteristics.” Invited presentation at the Joint Statistical Meetings, Seattle, WA, August 6, 2006.

Edwards LJ, Muller KE, Gurka MJ, Stewart PW (2005) Selecting the Best Linear Mixed Model: The State of the Art for Longitudinal Data Analysis. Presented at the Joint Statistical Meetings, Minneapolis, Minnesota, August 9, 2005.

Stewart PW and DeMuth G. (2002) “Estimation in Longitudinal Studies of Continuous Measures that are Subject to Purposeful Censoring”. Presented at the March 2002 Meeting of the IBS / ENAR.

Kilaru R, Stewart PW (2001) “Application of a Monte Carlo EM Algorithm to Left-Censored Bivariate Normal Data”. Presented at the March 2001 Meeting of the International Biometric Society / ENAR.

Bowman D, Sen PK, Stewart PW (1999) “Statistical Methods for Obtaining Inferences about Projected Completors in Longitudinal Studies with Non-ignorable Dropout”. Presented at the Joint Statistical Meetings, Chicago, August 9, 1999.

Stewart PW (1998), "Longitudinal Analysis of Menstrual Cycle Variation in Hormones, Lipids, Lipoproteins, and Hemostatic Factors in a Three-Period Crossover Study," Presented at March 1998 Meeting of the IBS / ENAR.

Cox T and Stewart PW (1997), "Evaluation of the Performance of Mixed-Model Procedures for Ophthalmologic Data,"Presented at March 1997 Meeting of the IBS / ENAR.

Cox T and Stewart PW (1997), "Evaluation of the Performance of GEE Procedures for Ophthalmologic Data," Presented at March 1997 Meeting of the IBS / ENAR.

Stewart PW (1993), "Simultaneous Confidence Bands for Nonlinear Longitudinal Models," Presented at August 1993 Joint Meeting of the ASA, IBS, and the IMS.

Stewart PW (1992), "Methods for Tracking Analysis for Inconsistently Timed Longitudinal Data," Presented at August 1992 Joint Meeting of the ASA, IBS, and the IMS.

Stewart PW (1991), "Analysis of Dose-Response Curves for Censored Repeated Measures," Presented at August 1991 Joint Meeting of the ASA, IBS, and IMS.

Burchinal, MR., Stewart PW, Pekow, PS, Helms, RW. (1991), "Tracking in Inconsistently-Timed Longitudinal Pulmonary Function Data: Empirical Results," Presented at August 1991 Joint Meeting of the ASA, IBS, and IMS.

Stewart PW (1991), "Tracking Analysis for Inconsistently Timed Longitudinal Data,"

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Presented at June 1991 ASA Symposium on Longitudinal Data Analysis, Two page abstract published in Statistics in Medicine, 11, 2027-2040.

Stewart PW (1990), "Classification Tree Prediction of Caries Using Clinical, Microbiological and Interview Data," Presented to November 1990 Meeting of The Task Force on Design and Analysis (for Dental Research) in New Brunswick, NJ. Stenographer's verbatim transcript published in Transactions of The Task Force on Design and Analysis.

Stewart PW (1990), "Methods for the Analysis of Tracking in Inconsistently-Timed Longitudinal Data," Presented at Aug.'90 Joint Meeting of the ASA, Biometric Society, and the IMS.

Stewart PW (1990), "Classification Tree Prediction of Caries Using Clinical, Microbiological and Interview Data," Presented at Mar.'90 Meetings of the International Association of Dental Research.

Stewart PW (1989), "The Graphical Advantages of Finite Interval Confidence Band Procedures," Presented at Aug.'89 Joint Meetings of the ASA, Biometric Society, and IMS.

Stewart PW (1987), "Methods for Evaluation of Once-Repeated Measures for Evidence of Tracking," Presented at Aug.'87 joint Meetings of the ASA, Biometric Society, and IMS.

Stewart PW (1984), "Extension of the quantile estimator proposed by Harrell and Davis to finite populations," Presented at Mar.'85 Meetings of the International Biometric Society.

Stewart PW, Helms RW (1979), "The Analysis of Growth and Dose-Response Curves," Presented at Aug.'79 Joint Meetings of the ASA, Biometric Society, and IMS. Published in ASA Proceedings of Statistical Computation Section, 130-135.

* Stewart PW, Helms RW (1979), "LINMOD Analysis of Growth and Dose-Response Curves," Presented at Aug.'79 The Conference of SAS Users Group International. Published in Proceedings of the 4th Annual Conference of the SUGI, 266-271.

* award for Best Paper on Linear Models at this annual conference.

Helms RW, McCanless I, Christiansen DH, Hosking JD, Muller KE, Stewart PW (1979), "Using GLMM5 for general linear models analysis: A tutorial", Presented at Fourth Annual SAS Users Group International Conference. Published in Proceedings of the SUGI Conference, pp 234- 271.

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3. Selected Original Research Presentations: Medical, Dental, & Public Health Papers

McDonnell W, Stewart PW, Smith M (2008) “Modification of a Human Ozone Exposure-Response Model and Evaluation of Its Performance in Predicting Mean Changes in FEV1 in Independent Data.” U. S. Environmental Protection Agency Workshop on Ozone, October, 2008.

Kipp AM, Stewart PW, Pungrassami P, Chongsuvivatwong V, van Rie A. “TB stigma trajectory among patients completing TB treatment in Southern Thailand”. AIDS Conference, Mexico City, 2008.

Dow A, Mupuala A, Stewart PW, van Rie A. “The Effects of Provision of HIV care on Neurodevelopment of Preschool children. AIDS Conference, Mexico City, 2008

Hoffman IF, Martinson FEA, Fiscus SA, Sohoni P, Komoltri C*, Chilangozi DA, Kazembe PN, Stewart PW, and Cohen MS. “Factors Affecting the Detection of HIV-1 RNA in Breast Milk.” 14th Conference on Retrovirus and Opportunistic Infections (CROI), Los Angeles, CA, February 25-28, 2007.

Sigounas D, Stewart PW, Samer E, Bullitt E, Kilpatrick M, Ewend (2007) "A New Measurement Criterion For Volumetric Evaluation Of Metastatic Brain Tumors”. Presented to the Society of Neuro-Oncology, Dallas, Texas, November 15-18, 2007.

Pilcher C, Tien H-C, Stewart PW, Vernazza P, Chakraborty H, Eron J Jr, Cohen M (2007). “Estimating Transmission Probabilities over Time in Acute HIV Infection from Biological Data” 14th Conference on Retrovirus and Opportunistic Infections (CROI), Los Angeles, CA, February 25-28, 2007.

Dumond JB, Yeh RF, Patterson KB, Corbett AH, Jung BH, Rezk NL, Bridges AS, Stewart PW, Cohen MS, Kashuba ADM (2007). Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis. 14th Conference on Retrovirus and Opportunistic Infections (CROI), Los Angeles, CA, February 25-28, 2007.

Fiscus SA, Cachafeiro A, Stewart PW, Napravnik S, Frank I, Eron J Jr, and the AACTG NWCS 227 Team (2007). “Cavidi Exavir Viral Load and Phenotype Assays” 14th Conference on Retrovirus and Opportunistic Infections (CROI), Los Angeles, CA, February 25-28, 2007.

Hoffman IF, Martinson FEA, Fiscus SA, Sohoni P, Komoltri C, Chilangozi DA, Kazembe PN, Stewart PW, and Cohen MS. “Factors Affecting the Detection of HIV-1 RNA in Breast Milk.” 14th Conference on Retrovirus and Opportunistic Infections (CROI), Los Angeles, CA, February 25-28, 2007.

Powers JM, Gourlay, Ensrud KE with guidance from Stewart PW (2006). ROC-GLM Comparison of Osteoporosis Risk Assessment Tools. Presented at the Joint Statistical Meetings, Seattle, WA, August 6, 2006.

Fiscus SA, Cachafeiro A, Stewart PW, Napravnik S, Frank I, Eron J Jr, and the Adult ACTG NWCS 227 Team. (2006). Cavidi Exavir Viral Load and Phenotype Assays.Presented at the 13th Annual Conference on Retroviruses and Opportunistic Infections.

Pilcher C, Tien H-C, Stewart PW, Vernazza P, Chakraborty H, Eron JJ Jr, Cohen MS. (2006) Estimating Transmission Probabilities over Time in Acute HIV Infection from Biological Data. Presented at the 13th Annual Conference on Retroviruses and Opportunistic Infections.

Hoffman I, Martinson FEA, Fiscus SA, Sohoni C, Komoltri C, Chilangozi DA, Kazembe PN, Stewart PW, Cohen MS. (2006). Factors Affecting the Detection of HIV-1 RNA in Breast Milk. Presented at the 13th Annual Conference on Retroviruses and Opportunistic Infections.

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Paine MF, Ludington SS, Chen ML, Stewart PW, Huang SM, Watkins PB (2005). Does sex influence proximal small intestinal cyp3a or p-gp expression? Presented at the ASCPT meetings March, 2005.

Paine MF, Ludington SS, Chen ML, Stewart PW, Huang SM, Watkins PB (2005). Does sex influence proximal small intestinal cyp3a or p-gp expression? Presented at the FDA Science Forum, April 2005.

McDonnell WF, Stewart PW, Smith MV (2003). A Dynamic Nonlinear Model of Ozone-Induced FEV1 Response Under Changing Exposure Conditions. Presented at the 99th Conference of the American Thoracic Society, Seattle, May 21, 2003.

Moe CL, Stewart PW, Savitz D, Koltai D, Loomis D, Hutton S, Bell P (2003). NC Study of Estuaries and Rivers and Cohort Health (NC SEARCH): Preliminary Results. Presented to CDC, Wilmington, NC, October 31, 2003.

Stewart PW, Moe CL, Savitz D, Koltai D, Loomis D, Hutton S, Bell P (2003). NC Study of Estuaries and Rivers and Cohort Health (NC SEARCH): Statistical Methods and Preliminary Results. Presented to CDC, Atlanta, GA, January 29, 2003.

Stewart PW, Moe CL, Savitz D, Koltai D, Loomis D, Hutton S, Bell P (2003). NC Study of Estuaries and Rivers and Cohort Health (NC SEARCH): Illustrated Methods and Plans for Statistical Analysis of Study Data. Presented to CDC, Richmond, VA, April 16, 2003.

Pilcher CD, Tien HC, Stewart PW, Vernazza PL, Cohen MS. (2002) Estimating Transmission Probabilities over Time in Acute HIV Infection from Biological Data. (CFAR-supported). Abstract 366-M. Presented at the 9th Conference on Retroviruses and Opportunistic Infections, Seattle, Feb 24-28, 2002.

Pilcher CD, Tien HC, Vernazza P, Stewart PW, Chakraborty H, Eron J, Cohen M (2002). Semen Viral Dynamics In Acute HIV Infection: Implications for Sexual Transmission. (CFAR-supported). Abstract 367-M. Presented at XIV International Conference on AIDS

Lindesmith L, Moe CL, Stewart PW, Baric RS (2001) “Evidence of Protective Mucosal Immune Response to NV Infection.” (Acknowledged Lauren Lindblad.) Presented at a symposium of the US EPA, RTP, NC. July 2001.

Jere CS, Hoffman I, Stewart PW, Kilaru R, Broadhead RL, Molyneux ME, Hart CA, Cunliffe NA, and Fiscus SA. (2000) “HIV Viral Loads in HIV Infected Malawian infants Co-infected with Rotavirus.” (CFAR-supported.) XIII International AIDS Conference, Durban South Africa, July 2000.

Hoffman IF, Martinson FEA, Fiscus SA, Sohoni P, Komoltri C, Chilongozi DA, Kazembe PN, Stewart PW, Cohen MS (2000) “Factors Affecting the Detection of HIV RNA in Breast Milk.” (CFAR-supported) XIII International AIDS Conference, Durban South Africa, July 2000.

Wohl D, Ngo B, Fiscus S, Handy J, Alcorn T, Cronin M, Pan W, Rosen D, van der Horst C, et al. (2000) “CMV Viremia and the Risk of CMV End-Organ Disease or Death in Patients with AIDS”. 7th Conference on Retroviruses and Opportunistic Infections, San Francisco, January 2000. (Acknowledgements to CFAR Bios Core support from PW Stewart.*)

September 18, 2009 ( See last page for Table of Contents ) Page 20

( 3. Original Research Presentations: Medical, Dental, & Public Health Papers , continued )

Stephenson B, Wohl D, Kiziah N, et al. (2000) “Release from Prison is Associated with Increased HIV RNA at Time of Reincarceration”, XIII International AIDS Conference, Durban, South Africa, July 2000.(Acknowledgements to CFAR Bios Core support.)

Bristow CL, Patel H, Arnold RR, et al. (2000) “A Self Antigen Prognostic for HIV Disease Progression”. XIII International AIDS Conference, Durban, South Africa, July 2000. (Acknowledgements to CFAR Bios Core support.*)

Phillips KM, Simpkins AH, Amanna KR, Wolf W, Stewart KK, Clark S, Kim KP, Beecher GR, Holden J (2000) “Long-Term Stability of Nutrients in a Frozen Mixed Food Control Material”. (DELTA* MS#111) Presented at the BERM-8 Meeting, Bethesda, MD, Sept 2000.

McDonnell WF (2000) "Ambient Ozone: Development of Exposure-Response Models for the Acute Respiratory Effects of Inhaled Irritants in Humans: Effects of Concentration, Minute Ventilation, and Duration” invited paper at U.S. EPA Symposium on “Indictators of Health and Ecological Risk Assessment” June 2000, RTP, NC. (Acknowledgements to Stewart PW, Marjo Smith, Pan W ).

Moe C, Stewart PW (2000), “Nonlinear Mixed-Effects Models for Norwalk Virus Dose Response” Presented at the W.H.O. Workshop on Hazard Characterization of Pathogens in Food and Water, June 2000, Bilthoven, Netherlands.

McDonnell WF, Stewart PW (1999). “Exposure-response modeling of ozone-induced FEV1 changes in humans: Effects of concentration, duration, minute ventilation, & age.” Presented at Workshop on Quality Assurance of Environmental Models; Sponsored by National Center for Statistics and the Environment (NRCSE) and by the U.S.E.P.A.” Seattle, September 7-10, 1999.

Davenport ML, Punyasavatsut N, Gunther D, Savendahl L, Stewart PW (1999) “Turner syndrome: a pattern of early growth failure.” Presented at Endocrinology Workshop sponsored by Pharmacia & UpJohn, Nice, France, April 15, 1999.

Fiscus SA, Hoffman IF, Stewart PW, Kilaru R, Broadhead RL, Molyneux ME, Hart CA, and Cunliffe NA. (1999) HIV viral loads in HIV-infected Malawian infants co-infected with rotavirus. 2nd Conference on Global Strategies for the Prevention of HIV Transmission from Mothers to Infants, Montreal, Canada, September 1999.

Kris-Etherton PM, Stewart PW, for the DELTA Investigators (1998), "Prediction Equations for Hemostatic Factors." Presented at April '98 Meeting of the Fed. of Am. Societies of Exper. Biology. (FASEB)

DuFort V, Kotch J, Stewart PW, Harb M, McMurray M (1998), “Are home-care children different from out-of-home care children?” Presented to the 4th World Conference on Injury Prevention & Control, Amsterdam.

Moe C, Stewart PW, Harb M (1998), “Norwalk Virus Dose Response” Presented to the U.S. Environmental Protection Agency, RTP, NC.

Davenport M, Punyasavatsut N, Stewart PW, (1998), “Growth in Infancy and Childhood in Turner’s Syndrome: New Growth Charts” Presented at the Endocrine Society Conference, June 1998.

September 18, 2009 ( See last page for Table of Contents ) Page 21

( 3. Original Research Presentations: Medical, Dental, & Public Health Papers , continued )

Kotch JB, Fieberg J, Brennan M, Dufort V, McMurray M, Stewart PW (1996), “Injuries Among Children In Home And Out-Of-Home Care” Presented at the National Head Start Research Conference, Washington, DC.

Kris-Etherton PM, for the DELTA Investigators* (1996), "Cholesterol Lowering Diet Effects on Biologic Covariation Among Plasma Total Cholesterol, Triglyceride, & Factor VIIc Levels." Presented at Apr.'97 Meeting of the Fed. of Am. Societies of Exper. Biology.

Dennis BH, for the DELTA Investigators* (1996), "Diet Design for Multicenter Studies of Diet and Lipoproteins in Humans." Presented at Nov.'96 Meeting of the American Heart Association.

Berglund L, for the DELTA Investigators* (1996), "HDL Subclass Pattern During Reduction of Dietary Saturated Fatty Acids in Healthy Subjects." Presented at Nov.'96 Meeting of the American Heart Association.

Ershow A, for the DELTA Investigators* (1996), "Dietary Effects on Lipoproteins and Thrombogenic Activity in Subjects with Markers for Insulin Resistance (DELTA2): Study Design and Recruitment." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Phillips K, for the DELTA Investigators* (1996), "Diet Composition Validation and Monitoring as Part of a Multicenter Clinical Feeding Trial of Step 1, High Mono-Unsaturated Fat, and Average American Diets." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Kris-Etherton PM, for the DELTA Investigators* (1996), "Effects of Replacing Saturated Fat (SFA) with Mono-Unsaturated Fat (MUFA) or Carbohydrate (CHO) on Plasma Lipids and Lipoproteins in Individuals with Markers for Insulin Resistance." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Elmer PT, for the DELTA Investigators* (1996), "Effects of a Step1 Diet and a High Mono-Unsaturated (MUFA) Fat Diet on Hemostatic Factors in Individuals with Markers for Insulin Resistance." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Lefevre M, for the DELTA Investigators* (1996), "Do ApoB & ApoA-IV Polymorphisms Affect Lipid Response to Reductions in Dietary Saturated Fat in Humans." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

------* Includes Stewart PW who designed the analysis strategy and co-authored abstract, paper, & presentation.

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( 1.3 Original Research Presentations: Medical, Dental, & Pub. Health Papers, continued...)

Ginsberg HN, for the DELTA Investigators* (1996), "Step1 Diet and a High Mono-Unsaturated Fat-Modified Step1 Diet Have Equal [or Similar] Effects on Post-Prandial Lipids and Glucose Levels in Patients with Markers for Insulin Resistance." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Berglund L, for the DELTA Investigators* (1996), "Variation of HDL Subclass Pattern During Dietary Intervention in Subjects with Markers for Insulin Resistance." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Reed RG, for the DELTA Investigators* (1996), "Cyclic Variability of Plasma Lipids, Lipoproteins, and Thrombogenic Factors in Premenopausal Women." Presented at Apr.'96 Meeting of the Fed. of Am. Societies of Exper. Biology.

Reed RG, for the DELTA Investigators* (1995), "Variance in Serum Lipids and Lipoproteins with Menstrual Cycle in Premenopausal Women." Presented at May'95 Meetings of the American Association for Clinical Chemistry. Abstract published in Clin. Chem. 41, S136 (1995).

Reed RG, for the DELTA Investigators* (1995), "Variance in Lipids & Lipoproteins With Menstrual Cycle in Premenopausal Women Is No Greater Than Variance in Postmenopausal Women or Men". Presented at Mar.'95 Confer. on Cardiovascular Disease Epidemiology & Prevention. Abstract published in Circulation 91, 923 (1995).

Reed RG, for the DELTA Investigators* (1995), "Dietary Fat in Women: Do Effects on Lipids Vary with Menstrual Status?" Presented at Apr.'95 Meetings of the Fed. of Am. Societies of Exper. Biology. Abstract published in the FASEB Journal 9, A290 (1995).

Elmer PT, for the DELTA Investigators* (1995), "Dietary Effects on Lipoproteins & Thrombogenic Activity: Effects of Reducing Dietary Total & Saturated Fats on Hemostatic Factors" Presented at Apr.'95 Meeting of the Fed. of Am. Societies of Exper. Biology.

Ginsberg HN, for the DELTA Investigators* (1995), "Diet Effects on Lipids & Thrombogenic Activity: Effects of Reducing Dietary Total & Saturated Fat on Plasma Lipids and Lipoproteins", Presented at Apr.'95 Meeting of the Fed. of Am. Societies of Exper. Biology.

Lefevre M, for the DELTA Investigators* (1995), "Relationship Between ApoE Genotype and Lipid Response to Dietary Saturated Fat", Presented at Apr.'95 Meeting of the Fed. of Am. Societies of Exper. Biology.

------* Includes Stewart PW who designed the analysis strategy and co-authored abstract, paper, & presentation.

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( 1.3 Original Research Presentations: Medical, Dental, & Pub. Health Papers, continued...)

Ershow A, for the DELTA Investigators* (1995), "Dietary Effects on Lipoproteins and Thrombogenic Activity: Rationale and Design", Presented at Apr.'95 Meeting of the Fed. of Am. Societies of Exper. Biology.

McDonnell B, Stewart PW, Smith M, (1995), "Respiratory Response to Varying Levels of Ozone as a Function of Minute Ventilation Rate". Presented at May'95 Meetings of the American Thoracic Society. Abstract published in Proceedings of the ATS, (1995).

Henry MM, Stewart PW, Henderson FW, (1994), "Longitudinal study of, allergy, wheezing illnesses, and lung function in a population of children in Raleigh, NC." Presented at May'94 Meetings of the American Thoracic Society.

Margolis MQ, Hunt RJ, Vann WF, Stewart PW (1993), "Caries Risk Assessment in Primary Teeth of First Grade Children", (Masters' Thesis), Presented at Mar.'93 Meetings of International Association of Dental Research.

Stamm JW, Stewart PW (1992). "Risk Factor Models for Caries Prediction." Presented at Jul.'92 International Conference on Oral Biology, Edinburgh, Scotland.

Stamm JW, Disney JA, Beck JD, Weintraub JA, Stewart PW (1991), "Caries Risk Assessment for Children According to Prior Caries Experience." Presented at Jun.'91 Conference on Cariology For the Nineties, Rochester, NY.

Weintraub JA, Kaste LM, Beck JD, Stewart PW, Abernathy J, Disney JA (1991), "Caries Risk Assessment for Children According to Prior Caries Experience." Presented at Jul.'91 Meetings of International Association of Dental Research,

Stamm JW, Stewart PW, Bohannan HM, Disney JA, Graves RC, Abernathy JR (1990), "Risk Assessment for Oral Disease." Presented at Prevention Revisited: A Special Symposium, Seventy-Fifth Anniversary Celebration, Eastman Dental Center, Rochester, NY; Sep.'90.

Scruggs RR, Stewart PW, Samuels MS, Stamm JW (1990), "Attitudinal assessment of students with curriculum changes." Presented at '89 Meeting of American Association of Dental Schools, New Orleans.

Scruggs RR, Stewart PW, Samuels MS, Stamm JW, (1989), "Clinical evaluation of six anti-calculus dentifrice formulations." Presented at Mar.'89 Meetings of International Association of Dental Research.

Piazza FM, Henry MM, Muelenaer AA, Ivins SS, Stewart PW, Henderson FW, Voter KZ, Strope GL (1988), "Wheezing associated lower respiratory illness in early childhood and later lung function in non-asthmatic black children". Presented at May'88 Meetings of the American Thoracic Society.

Muelenaer AA, Henry MM, Piazza FM, Ivins SS, Stewart PW, Henderson FW, Voter KZ, Strope GL (1988), "Bronchial responsiveness to isoetharine and methacholine in healthy, non-asthmatic black children". Presented at May'88 Meetings of the American Thoracic Society. ------* Includes Stewart PW who designed the analysis strategy and co-authored abstract, paper, & presentation.

September 18, 2009 ( See last page for Table of Contents ) Page 24

BUSINESS EXPERIENCE Statistical Sciences Consulting Practice (sole proprietor)

Methods for nonlinear random effects models in analysis of ozone exposure-response data from human volunteers: derivation, validation and publication of statistical methods for clustered ozoneexposure data. Dr. William McDonnell, US EPA, RTP, NC

Clinical trials protocols: formulation and writing of sections on study design and plans for analysis Dr. Beth Fetterman, PharmaLink FHI, RTP, NC

Pulmonary function, cystic fibrosis, and missing-data methods Dr. S. Hamilton Genentech, Inc., South San Francisco, CA

Clinical trials protocols and sequential methods: hepatic metabolism and liver disease research. Dr. Michael Fried, MD

Methods for nonlinear random effects models in meta-analysis of human exposure-response data: derivation, validation and publication of statistical methods for clustered Toluene data. Dr. Vernon Benignus, US EPA, RTP, NC

Pulmonary function, brochodilators, and longitudinal methods Drs. J. Ward and I. McCanless Glaxo, Inc., Research Triangle Park, NC

Longitudinal prediction of financial performance, data warehousing, data mining Mr. D. Thomas, Chief Auditor, ITT Sheraton World Headquarters, Boston, MA

Oral contraceptives, galactose, heart disease, and crossover designs Dr. E. Bisgrove Family Health International, RTP, NC

Correlates of infant mortality in Africa, and graphical methods Mr. P. Roark US-AID: WASH Project, Arlington, VA

Dentistry and the prediction of caries in children Dr. N. W. Chilton Task Force on Design and Analysis, Lawrenceville NJ

Detection of child abuse, prediction intervals, and tolerance intervals Dr. David Ingram Wake County Medical Center, Raleigh, NC

Growth-curve analysis methodology and algorithms Dr. S. L. Lee National Institutes of Health, Washington, DC

Longitudinal designs, GEE methods, and hair growth cycles Dr. R. Anderson Harvard U., Boston, MA

Longitudinal analysis of infrared laser clinical trials Ms. M. Moore Palomar Medical Technologies, Boston, MA

September 18, 2009 ( See last page for Table of Contents ) Page 25

CURRENT COLLABORATIVE RESEARCH

2008-present Co-Investigator and Biostatistician Biostatistics Core of the UNC TraCS Institute UNC CTSA Initiative

2007-present Co-Investigator and Biostatistician Study of CYP2B6 Genotype and Phenotype UNC School of Pharmacy

2008-present Co-Investigator and Biostatistician, Study of CYP3A Activity Measures, UNC School of Pharmacy.

PREVIOUS COLLABORATIVE RESEARCH

1997-2008 Director of Biostatistics Core, Mentor in K12/K30 Program, General Clinical Research Center (GCRC)** UNC School of Medicine.

1998-2008 Director of Biostatistics Core, UNC Center for AIDS Research (CFAR)*

2001-2008 Co-Investigator and Biostatistician, Study of Pulmonary Inflammation in Cystic Fibrosis, UNC Department Pediatrics.

1999-2008 Co-Investigator and Biostatistician, Adult Pulmonary Ozone Studies of Exposure-Response. US-EPA, RTP, NC.

1999-2008 Co-Investigator and Biostatistician, Intervention to Improve Patient Compliance* UNC CFAR

1996-2006 Co-Investigator and Biostatistician, Longitudinal NC SEARCH Project* A prospective cohort study of estuary-associated syndrome in NC. CDC, NC, and UNC Department of Epidemiology.

2001-2006 Co-Investigator and Biostatistician, Gender, Nicotine and Stress-Induced Analgesia, UNC Department of Psychiatry.

* * Project supported Biostatistics Graduate Research Assistant (GRA) supervised and trained by Dr. Stewart.

September 18, 2009 Page 26

( PREVIOUS COLLABORATIVE RESEARCH, continued )

1998-2007 Co-Investigator and Biostatistician, Study of Choline as an Essential Dietary Nutrient, UNC Department of Nutrition.

2002-2003 Co-Investigator and Biostatistician, Study of Inflammatory Bowel Disease. UNC Department of Medicine. (Transferred project to Dr. Gail Tudor in 2003)

2001-2003 Co-Investigator and Biostatistician, Cytomegalovirus in HIV Patients* CFAR and UNC School of Medicine. (With Dr. Donglin Zeng)

2002-2003 Co-Investigator and Biostatistician, Modeling Acute HIV Dynamics* CFAR and UNC School of Medicine. (With Dr. Hsiao-Chuan Tien)

1996-2002 Co-Investigator and Biostatistician, US-EPA Norwalk Virus Study of Exposure-Response. UNC Departments of Biostatistics and Epidemiology.

1999-2003 Consulting Biostatistician, Center for Inflammatory Disease, UNC School of Dentistry. (Transferred to Dr. John Priesser in 2003)

2000-2003 Consulting Biostatistician, Department of Orthodontics, UNC School of Dentistry. (Transferred to Dr. John Priesser in 2003)

1996-2003 Principal Investigator, Coordinating Center of NHLBI DELTA Program. Randomized multicenter collaborative trials for effects of experimental isocaloric diets on lipids, lipoproteins, and hemostatic factors. UNC Biostatistics Department.

1992-1999 Principal Investigator, Adult Pulmonary Ozone Studies of Exposure-Response.* US-EPA air quality research funded via UNC Cooperative Agreement. UNC Departments of Epidemiology and Biostatistics.

1997-2000 Consulting Biostatistician, Thurston Arthritis Research Center (TARC) *

September 18, 2009 Page 27

( PREVIOUS COLLABORATIVE RESEARCH, continued )

1996-1998 Principle Investigator of subcontract, Penn. State Univ., Chocolate Manufacturers Association Study #1.* UNC Biostatistics Department.

1997-1999 Principal Investigator, Coordinating Center for the ACTA Study in the TARC.* Randomized multicenter collaborative trial comparing Arthrotec and Acetaminophine in arthritis patients. (Searle, Inc.) (Transferred to Dr. Gary Koch)

1990-1997 Investigator, The Long-Scan Study* A Longitudinal Study of Risk of Abuse / Neglect. UNC Department Maternal & Child Health.

1993-1997 Co-Principal Investigator, Longitudinal Study of Injuries Among Children During Daycare.* UNC Department of Maternal & Child Health.

1992-1997 Co-Investigator, Biometry Core of NHLBI Duke-UNC Sickle Cell Center.* UNC Department of Biostatistics.

1992-1996 Co-Principal Investigator, Coordinating Center of NHLBI DELTA Program.* UNC Department of Biostatistics.

1986-1995 Biostatistician, Dental Research Center, UNC Department of Dental Ecology.

1986-1993 Investigator, NIDR Caries Risk Assessment Study.* UNC Department of Dental Ecology.

1992-1994 Co-Investigator and primary author of R03 grant, NHLBI-UNC Study of Pediatric Lung Function, Viral Illness, Allergy, Environmental Tobacco Smoke in African-American Girls. * UNC Frank Porter Graham Child Development Research Center.

1992-1993 Consulting Statistician, CSCC- NHLBI "Study of Left Ventricular Dysfunction" (SOLVD). * UNC Biostatistics Department.

September 18, 2009 Page 28

1982-1991 Co-Investigator and Director of Biostatistics Unit, Biometry Core of the NHLBI-UNC Pediatric Pulmonary SCOR. * UNC Departments of Biostatistics Department and Pediatrics.

1982-1991 Co-Investigator on Multiple Projects, NHLBI-UNC Pediatric Pulmonary SCOR. * Longitudinal Studies of Lung Function and Respiratory Illness. UNC Departments of Biostatistics and Pediatrics.

1982-1982 Investigator on NHLBI Lipid Research Clinics (LRC) Program, Biostatistics Department, School of Public Health, The University of North Carolina, Chapel Hill.

PRE-DOCTORAL EMPLOYMENT

1981-1982 Graduate Research Trainee, Pre-Doctoral Award, Administered by Dr. C. E. Davis. UNC Biostatistics Department.

1978-1981 Graduate Research Assistant, CDC-UNC SENIC Project, Assisting Dr. R. J. Carroll and Dr. D. Quade. UNC Biostatistics Department.

1977-1978 Graduate Research Assistant, AID-UNC Guatemala Water and Sanitation Project, Assisting Dr. R. W. Helms. UNC Biostatistics Department.

1975-1977 Graduate Teaching Assistant, Assisting Dr. E. Wegman, UNC Statistics Department.

JOURNAL SERVICE Referee of submitted articles for the following journals JASA, Biometrics, Technometrics, American Statistician, Pediatric Pulmonology, Statistics & Computing, Environmental Statistics, Journal of Dental Research, American Journal of Respiratory and Critical Care Medicine.

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ADMINISTRATIVE SERVICE FOR THE UNC DEPARTMENT OF BIOSTATISTICS 2006-present Member Biostatistics Information Technology 1992-2006 Chairman Biostatistics Information Technology 2003-2003 Chairman Committee on Continuation of Business / Emergency Response 1991-1993 Chairman Biostatistics Seminar Committee 1990-1991 Advisor Biostatistics Advisory Committee on Information Technology 1989-1997 Member Biostatistics Seminar Committee 1985-1991 Member Examinations Committee 1982-1992 Member Statistical Computing and Data Management Committee 1985-1986 Member Linear Models Courses Committee (ad hoc) 1994-1995 Member SPH Dean's Computer & Data Processing Advisory Committee 1996-1996 Member SPH Dean's Committee for Review of Information Technology

TEACHING EXPERIENCE (Teaching Portfolio)

Dr. Stewart's experience in teaching has been in a variety of settings within and apart from the School of Public Health. Most of his experience has occurred in the process of training and supervising a large number of students of biostatistics who have worked with Dr. Stewart on collaborative bio-medical research projects as graduate research assistants (GRAs). This activity has involved thousands of hours of direct, practical training and instruction in statistical methods, research database management, statistical computing, consulting skills, and scientific writing. In addition, Dr. Stewart has directed the thesis research of seven students of biostatistics (BIOS 393 and BIOS 394) and has served as an active member of more that 30 other thesis committees. Dr. Stewart has also supervised the required practical consulting experiences (BIOS 242) of 15 students. In addition to these one-to-one teaching experiences, Dr. Stewart has also provided approximately 355 credit hours of instruction in the classroom setting. (credit hours per student × number of students.) Dr. Stewart has also provided tutorials and seminars to groups and clients in the Schools of Medicine, Dentistry, Pharmacy, and Public Health and to other groups apart from the UNC system. Dr. Stewart maintains a teaching portfolio that is available upon request. It addresses the following three components of his experience in teaching. 1) The Process: How, When, and Where One Teaches 2) The Content: Peer Review of What One Teaches 3) The Outcomes: The Effects of Teaching on the Student

COMPUTER SOFTWARE

1980 LINMOD/GCMPACK: a module for analysis of Dose-Response Curves and Growth Curves: The current version of the LINMOD software system for the analysis of univariate and multivariate data by general linear models was provided by Keith Muller and was initially developed by R.W. Helms, J.D. Hosking, and D.H. Christiansen with later assistance by K. E. Muller and P. W. Stewart. LINMOD is a software system for the analysis of univariate data by general linear models., The LINMOD system originally included 4,500 statements in the SAS / PROC MATRIX language. In 1996 and again in 1997 K.E.Muller translated the code to SAS / PROC IML language and made needed revisions. Drs. Stewart and Muller have used LINMOD in BIOS263 and BIOS163 for instruction and discovery. The GCMPACK module includes approximately 3000 SAS statements. The LINMOD system (including GCMPACK) is in use in several of the National Institutes of Health, at several pharmaceutical manufacturing companies, and universities in the U.S., Canada, Brazil, and Chile. Documentation is in the following: -- Stewart and Helms (1979-a) (Given above) -- Stewart and Helms (1979-b) (Given above) -- Christiansen, Hosking, Helms, and Bourassa (1979)

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-- Christiansen, Hosking, Helms, and Muller (1979) -- Helms, Christiansen (1979) -- Hosking, Christiansen, Helms (1979)

1990 CPUSERVER: system software allowing users on a local area network to share remote batch processors. SAS programs and other programs enter a queue and run in batch mode. SAS programs are placed in the queue by simply copying the program file into the network directory named “q:\”. All results appear with the program file in directory “r:\” when the results are ready for review.

1992 TRACKING.IML: a set of modules for analysis of tracking via mixed-model analysis of growth curves (dose- response) curves. The modules include approximately 1000 statements in the SAS PROC IML language; about half are internal documentation.

1996 LM_MACRO.SAS: a set of modules for longitudinal analysis of multi-dimensional responses. Comprises over 12,000 lines of code.

2000 BIV_EM.SAS: a set of modules for longitudinal analysis of bivariate or trivariate outcomes that are subject to left- censoring; e.g., censored below a lower limit of detection.

2005 IML_CENSAD.SAS: a translation of the CENSAD FORTRAN algorithm for fitting linear mixed-effects models to left censoring longitudinal data. The new code uses SAS / PROC IML.

September 18, 2009 Page 31

CONTRACTS AND GRANTS RECEIVED

Project Title NC TraCS Biostatistics Core Description NIH CTSA Award. Prin. Investigator Michael Kosorok, UNC Biostatistics Dept. Role of PW Stewart Biostatistician for “Collaboration”, “Methods Research”, “Training”, and the CTSA Graduate Assistants Ja-An Lin Funded 19 May 2008 − Funding Agency NIH Award NIH and UNC support for CTSA Initiative

Project Title CFAR Biostatistics Core Description NIH Center for AIDS Research: Core F. Prin. Investigator PW Stewart, UNC Biostatistics Dept. Role of PW Stewart Chief statistician, Director. Other Co-Investigators Francoise Seillier-Moiseiwitsch Graduate Assistants Chula Komoltri, Rakhi Kilaru, Anita Shanker Funded 1 Sep 1998 – 31 Aug 2001, 1 Sep 2001 – 31 Aug 2006, 1 Sep 2006 – 31 Aug 2011. Funding Agency NIH Award Core: $99,130 total per year plus cost recovery fees

Project Title GCRC: Biostatistics Unit of UNC General Clinical Research Center Description Biostatistics Core of the UNC GCRC. Prin. Investigator Eugene Orringer, UNC School of Medicine. Role of PW Stewart Director of Biostatistics Core. Consultation / collaboration in design of biomedical research, comparison of competing statistical methods, selection/development of statistical methodology, grant writing, etc. for 156 projects in year 2003. Biostatistics Department liaison. Other Co-Investigators David Weber. Graduate Assistants Steve Cohen, Cathy Jenkins, Szu-Yun Leu. Funded 1 Dec 1997 - 30 Nov 2006 1 Dec 2007 - 30 Nov 2010 Web verne.med.unc.edu Funding Agency NIH GCRC Program Award Increased from 50%FTE to 110% FTE: 75% of Dr. Stewart + 50% of GRA.

Project Title Human Requirements for the Nutrient Choline Description A longitudinal feeding GCRC-related study in experimental subjects (eating different amounts of choline) with control subjects (eating matched diet to experimental subjects that has been adjusted to a fixed amount of choline. Prin. Investigator S Zeisel, UNC Nutrition Dept. Chairman Role of PW Stewart Co-investigator and chief statistician. Funded 07/01/2000 - 6/30/2005 Funding Agency NIDDK (1 R01 DK55865-01A2) Award $3,682,329 per five years.

Project Title NC Study of Estuary & River Cohort Health (NC-SEARCH) Description Longitudinal study relevant to concerns by CDC, EPA, and NIEHS about Pfiesteria. Involves biostatistical collaboration, design, longitudinal analysis, and publication of methods papers and study results. Prin. Investigator Christine Moe. www.cdc.gov, www.schs.state.nc.us/epi/hab/research.htm

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Role of PW Stewart Chief Statistician. Other Co_Investigators Dana Loomis, Deborah Koltai-Attix, Steve Hutton, Paula Bell. Graduate Assistants Szu-Yun Leu. Funded 1 Jul 1997 - 30 Jun 2001, plus 4 month extension. Funding Agency CDC & NC DHHS “Harmful Algal Blooms” Program Award 10% support for Dr. Stewart.

Project Title Dental Research: UNC Orthodontics Department Description Collaborative project development, grant preparation, consultation, and methodological research in the UNC Orthodontics Department. Prin. Investigator Ceib Phillips, PhD, MPH Role of PW Stewart Trial Statistician. (Transferred to John Preisser in Feb 2003)3 Web ortho.dent.unc.edu/MainUNCPage/orthopro.htm#Research Funded 1/1/2000 - 12/31/2005. Funding Agency NIH - NIDCR Award 5% for Dr. Stewart.

Project Title CF BALF Study of Surfactant Proteins and Inflammation: Description GCRC-related collaboration on design, grant application, experimentation, analysis, and publication. Part of a Pulmonary SCORE. Funding Agency NHLBI SCORE Program Prin. Investigator Terry Noah Role of PW Stewart Trial Statistician. Dates 1 Dec 2000 - 31 Nov 2003 Award 9% FTE for Paul Stewart.

Project Title Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis: Description GCRC-related collaboration on design, grant application, experimentation, analysis, and publication. Prin. Investigator Scott Donaldson Role of PW Stewart Trial Statistician. Dates 1 Jul 2000 - 30 Jun 2002 Funding Agency Cystic Fibrosis Foundation (CFF) Award 5% FTE for Paul Stewart

Project Title Gender, Nicotine and Stress-Induced Analgesia: Description GCRC-related collaboration on design, grant application, experimentation, analysis, and publication. Prin. Investigator Susan Girdler Role of PW Stewart Trial Statistician. Dates 1 Aug 2001 - 30 Apr 2005 Funding Source NIH-NIDA Award 5% FTE for Paul Stewart

Project Title Prediction Equations II: Dietary Effects on Hemostasis & Lipids Description Subcontract from Penn. State Univ. for biostatistical collaboration. Combines data from DELTA 1 & 2, the Dairy Study, and Judd Study. Prin. Investigator PW Stewart, UNC Biostatistics Dept. Role of PW Stewart Chief statistician, co-author. Other Co-Investigators Penny Kris-Etherton, Tom Pearson, et al. Graduate Assistants Chula Komoltri, Burton Levine Dates 1 July 1998 - 31 June 1999

3 Because Paul Stewart had too many funded projects.

September 18, 2009 Page 33

Funding Agency Chocolate Manufacturers Association Award $25,000 total for 1 year.

Project Title Prediction Equations I: Dietary Effects on Hemostasis & Lipids Description Subcontract from Penn. State Univ. for biostatistical collaboration. Combines data from DELTA 1 & 2. Prin. Investigator PW Stewart, UNC Biostatistics Dept. Role of PW Stewart Chief statistician, co-author. Other Co-Investigators Penny Kris-Etherton, Tom Pearson, et al. Graduate Assistants Chula Komoltri Dates 1 November 1996 - 31 December 1997 Funding Agency Chocolate Manufacturers Association Award $12,400 total for 1 year.

Project Title Norwalk Virus Exposure-Response Description Experimental research relevant to US-EPA water quality standards. Prin. Investigator Christine Moe, UNC Epidemiology Dept. Role of PW Stewart Biostatistician Graduate Assistants Michelle Harb Dates 1 July 1997 - 30 June 1999 Funding Agency U.S Environmental Protection Agency Award $10,000 direct over 2 years for the biostatistical component.

Project Title DELTA-I Closeout: Dietary Effect on Lipids and Thrombogenic Activity, Studies of Specific Fatty Acids in the American Diet Description Coordinating Center for Multicenter Clinical Trials Prin. Investigator PW Stewart, UNC Biostatistics Dept. Role of PW Stewart P.I., Author of grant, Chief Statistician. Other Co-Investigators BH Dennis, CW Wang, S Blackwell, CE Davis, JD Hosking, et al. Graduate Assistants Michelle Harb, Burton Levine, Chula Komoltri Dates 1 August 1997 - 30 September 1998 Funding Agency National Heart Lung and Blood Institute Award $112,674 total.

Project Title DELTA-II: Dietary Effect on Lipids and Thrombogenic Activity, Studies of Specific Fatty Acids in the American Diet Description Coordinating Center for Multicenter Clinical Trials Prin. Investigator PW Stewart, UNC Biostatistics Dept. Role of PW Stewart P.I., Author of grant, Chief Statistician. Other Co-Investigators BH Dennis, CW Wang, S Blackwell, CE Davis, JD Hosking, et al. Graduate Assistants Michelle Harb Dates 1 April 1997 - 31 March 2001 Funding Agency National Heart Lung and Blood Institute Requested Award $3,636,902 direct to UNC over 4 years. Note 6.8 percentile priority score awarded by IRG in October 1996. Funding not approved by NHLBI Council in February 1997. Appeal entered February 1997 to NIH Director and the Council. Funding not approved by NHLBI Council in March 1997. Award $112,674 total to UNC for 1 year: 1 Sep. 1997 - 31 Aug. 1998.

Project Title DELTA-I: Dietary Effect on Lipids and Thrombogenic Activity, Studies of Nutrient Profile Strategies Description Coordinating Center for Multicenter Clinical Trials Prin. Investigator PW Stewart beginning June 1, 1996; BH Dennis prior to June 1, 1996.

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Role of PW Stewart Co-author of grant, P.I./Co-PI, Chief Statistician. Other Co-investigators CW Wang, NY Anderson, S Blackwell, CE Davis, JD Hosking, et al. Graduate assistants Szu-Yun Leu, Michelle Harb Dates 1 September 1992 - 31 August 1996 Funding Agency National Heart Lung and Blood Institute Award $2,200,000 direct over 4 years.

Project Title Statistical Models & Methods for Ozone Exposure-Response Data Description Pulmonary experimental research relevant to revision of the US-EPA air quality standards. One of several projects in the UNC-EPA Cooperative Agreement. Prin. Investigator PW Stewart, UNC Biostatistics Dept. Role of PW Stewart Author of grant, Chief statistician Other Co-Investigators WR McDonnell, MV Smith Graduate Assistants Solange Andreoni, Elaine B. Hoffman, Paul Rathouz, Jean Pan Dates Renewed annually: 1 July 1992 - 30 June 1997 Funding Agency U.S. Environmental Protection Agency Award $375,000 direct over 5 years.

Project Title Thurston Arthritis Research Center Description Center, Projects, and Cores for interrelated basic and clinical research. Prin. Investigator John Winfield, UNC School of Medicine. Role of PW Stewart Chief Biostatistician in the Numerical Sciences Core, and Co-Investigator on Clinical Projects; for example, --Numerical Science Core (Blalock), --Self-Management Strategies and Health Outcomes (Callahan), --Johnston County Osteoarthritis Project (Jordan), --Osteoporosis Prevention in Women (Blalock), --Emotional Contagion (DeVellis), --Beta2-Glycoprotein I in Apoptosis (Reap), --Anti-nRNP/Sm Auto-Antibody Spreading Mech. (Satoh), and --Signaling Mech. in Myotendinous Junction Formation (Peng). Graduate Assistants George Luta Dates 1 July 1998 - 30 June 2002 Funding Agency NIH Award $3,770,782 direct over 4 years.

Project Title Combined Behavioral/Pharmacologic Treatment of Alcoholism (CBPTA) Project Description Coordinating center for a multicenter clinical trial. Prin. Investigator J Hosking, UNC Biostatistics Dept. Role of PW Stewart Author of the statistical methods section “Appendix C” (16 pages.) Dr. Stewart has chosen not to participate in the study. Other Co-Investigators JC Garbutt, M Youngblood, et al. Dates 1 October 1997 - 31 September 2003 Funding Agency NIAAA Award $3,407,169 direct over 6 years.

Project Title Injuries Among Children in Home and Out-of-Home Care Description Longitudinal study of prospectively documented injuries based on a random sample of families in the research triangle area. Prin. Investigator JB Kotch, UNC MCH Dept. Role of PW Stewart Co-Principal Investigator, Project Statistician Other Co-Investigators Marsha McMurry, Vincent Dufort, et al.

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Graduate Assistants John Fieberg, Michelle Harb Dates 1 July 1994 - 31 June 1996, with no-cost extensions. Funding Agency Bureau of Maternal & Child Health in the Department of Health and Human Services Award $300,000 direct over two years.

Project Title Biometry Core II: Duke-UNC Comprehensive Sickle Cell Center Description Core unit providing professional services in design, analysis, and data management to about 15 projects Prin. Investigator RW Helms, UNC Biostatistics Dept. Role of PW Stewart Co-author of grant, Co-investigator, Statistician on multiple projects Other Co-Investigators MR Burchinal, M Helms Graduate Assistants Elaine B. Hoffman Dates 1 April 1993 - 31 March 1998 Funding Agency National Heart Lung and Blood Institute Award $1,065,000 direct (prior to Gram-Rudman-Hollings budget cuts)

Project Title Biometry Core I: Duke-UNC Comprehensive Sickle Cell Center Description Core unit providing professional services in design, analysis, and especially data management to about 15 projects Prin. Investigator RW Helms, UNC Biostatistics Dept. Role of PW Stewart Co-author of proposed design for new Biometry Core, Co-Investigator Other Co-Investigators MR Burchinal, M Helms Graduate Assistants Elaine B. Hoffman Dates 1 April 1991 - 31 March 1992 Funding Agency National Heart Lung and Blood Institute Award $200,000 direct per two years (via rebudgeting to accommodate Core.)

Project Title Longitudinal Analysis of Spirometry in Black Children Description R03 Grant for analysis of existing database using new statistical methods for longitudinal data. Prin. Investigator FW Henderson, UNC Frank Porter Graham Child Development Center Role of PW Stewart Grant (R03) author, chief statistician, co-author Other Co-Investigators MM Henry, E Neebe Graduate Assistants Scott Hamilton Dates 1 April 1992 - 30 June 1994 Funding Agency National Heart Lung and Blood Institute Award $100,000 direct over two years

Project Title SCORE Biometry Core: Lung Injury by Childhood Infection Description Providing biomedical research services in UNC Pediatric-Pulmonary Specialized Center of Research (SCOR). Prin. Investigator RW Helms, UNC Biostatistics Dept. Role of PW Stewart Co-investigator & Director of the biostatistics component Other Co-Investigators K Fendt (Director of the data management component), FW Henderson (Director of the epidemiology component) Graduate Assistants L Helms, D Fairclough, K McCarroll, P Pekow Dates 1 December 1986 - 30 November 1991 Funding Agency National Heart Lung and Blood Institute Award $1,318,155 direct over five years

Project Title SCOR Project #1: Lung Function, Lower Respiratory Illness, Allergy, & Tobacco Smoke

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Description UNC Pediatric-Pulmonary Specialized Center of Research (SCOR) Prin. Investigator FW Henderson, UNC Pediatrics Dept. Role of PW Stewart Co-author of grant, Project Statistician Other Co-Investigators MM Henry, MR Burchinal, RW Helms Graduate Assistants CS Kleoudis, L Maxwell, GG Dahiya, A Kenan, G Davis, M Hunt, Lynn Bressler, S McNulty, M Martin, M Abulata, M Chen Dates 1 December 1986 - 30 November 1991 Funding Agency National Heart Lung and Blood Institute Award $550,000 direct over five years

Project Title SCOR Project #2: Analysis of Incomplete Longitudinal and Mulitvariate Data Description UNC Pediatric-Pulmonary Specialized Center of Research (SCOR) Prin. Investigator RW Helms, UNC Biostatistics Dept. Role of PW Stewart Co-investigator Graduate Assistants DL Fairclough, J Rochon, K McCarroll, SC Murray Dates 1 December 1986 - 30 November 1991 Funding Agency National Heart Lung and Blood Institute Award $501,500 direct over five years

Project Title Development of Anthropometric Strategies Description New Methods for Defining Patterns of Growth-Failure in Infants Prin. Investigator PW Stewart Co-Investigators JK Whitt, MG Busby, Penny Pekow(GRA) Dates 1 January 1990 - 31 April 1991 Funding Agency The Institute of Nutrition Award $4000 total, seed grant

Project Title Developmental Tracking Description New Analysis Methods for Spirometric Performance in Childhood Prin. Investigator PW Stewart Co-Investigators PS Pekow, MR Burchinal , Penny Pekow (GRA) Dates 1 January 1988 - 31 December 1988 Funding Agency FPG Child Development Center Award $5000 total, Innovative Research Awards Program

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TABLE OF CONTENTS PERSONAL ...... 1

EDUCATION...... 1

MAJOR PROFESSIONAL INTERESTS ...... 1

ACCADEMIC APPOINTMENTS...... 1

PROFESSIONAL SOCIETIES...... 1

HONORS AND DISTINCTIONS ...... 1

PUBLICATIONS...... 2

1. DISSERTATION ...... 2 2. BOOKS...... 2 3. REFEREED BOOK CHAPTERS ...... 2 6. REFEREED PUBLICATIONS ...... 3 6.1. Refereed Publications from the NIH–Funded DELTA Program...... 3 6.2. Refereed Statistical and Biomedical Publications (other than DELTA)...... 4 6.3. Refereed Publications with Acknowledgements to PW Stewart...... 10 6.4. BOOK REVIEWS ...... 11 7. Other Published Articles ...... 12 8. MONOGRAPHS ...... 12 8.1 Texts (not peer-reviewed)...... 12 8.2 Electronic Publications (not peer-reviewed)...... 12 COLLABORATION WITH STUDENTS...... 13

1. CURRENT AND PREVIOUS DOCTORAL STUDENTS IN COLLABORATIVE PUBLICATIONS ...... 13 2. DISSERTATION RESEARCH DIRECTED BY DR. STEWART...... 15 PRESENTATIONS ...... 16

1. SELECTED ORIGINAL RESEARCH PRESENTATIONS: SEMINAR FORMAT ...... 16 2. SELECTED ORIGINAL RESEARCH PRESENTATIONS: STATISTICAL RESEARCH ...... 17 3. Selected Original Research Presentations: Medical, Dental, & Public Health Papers...... 19 BUSINESS EXPERIENCE...... 25

CURRENT COLLABORATIVE RESEARCH...... 26

PREVIOUS COLLABORATIVE RESEARCH...... 26

PRE-DOCTORAL EMPLOYMENT ...... 29

JOURNAL SERVICE...... 29

ADMINISTRATIVE SERVICE FOR THE UNC DEPARTMENT OF BIOSTATISTICS ...... 30

TEACHING EXPERIENCE (TEACHING PORTFOLIO)...... 30

COMPUTER SOFTWARE...... 30

CONTRACTS AND GRANTS RECEIVED...... 32

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