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Please note, these are the actual video-recorded proceedings from the live CME event and may include the use of trade names and other raw, unedited content. Addressing Current Questions and Controversies in the Management of Multiple Myeloma, Waldenström Macroglobulinemia and Amyloidosis Friday, November 30, 2018 6:30 PM – 9:00 PM San Diego, California

Moderator Neil Love, MD

Faculty Rafael Fonseca, MD Noopur Raje, MD Sagar Lonial, MD Professor Katja Weisel, MD Robert Z Orlowski, MD, PhD Disclosures for Moderator Neil Love, MD

Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive , Agendia Inc, Agios Pharmaceuticals Inc, Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Pharma Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis , Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, , Genomic Health Inc, Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Inc, administered by Janssen Scientific Affairs LLC, Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology, Medivation Inc, a Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro Inc, Teva Oncology and Tokai Pharmaceuticals Inc. Agenda

Module 1 – Dr Lonial: Up-Front Management of Multiple Myeloma

Module 2 – Dr Fonseca: Consolidation and Maintenance Therapy

Module 3 – Prof Weisel: Management of Relapsed/Refractory MM

Module 4 – Dr Raje: Novel Strategies Under Investigation for the Treatment of MM Module 5 – Dr Orlowski: Smoldering Myeloma, Amyloidosis and Waldenström Macroglobulinemia ASH Working Group Participants — August 29, 2018 Research To Practice — Miami, FL

Amy Bessnow, MD, MPH Suzanne Cole, MD Jewel Johl, MD Dover, New Hampshire Dallas, Pleasant Hill, California

Kapisthalam S Kumar, MD Erik Rupard, MD Rajni Sinha, MD New Port Richey, Florida West Reading, Pennsylvania Atlanta, Georgia Random National Survey of 100 General Medical Oncologists (October 2018) How often do you feel emotionally drained by your work as an oncologist?

Never 10%

A few times a year 18%

Once a month 8%

A few times a month 39%

A few times a week 20%

Every day 6%

0% 5% 10% 15% 20% 25% 30% 35% 40%

10% of oncologists responded “I prefer not to answer this question” Random National Survey of 100 General Medical Oncologists (October 2018) How often do you feel frustrated by your work as an oncologist?

Never 10%

A few times a year 25%

Once a month 4%

A few times a month 38%

A few times a week 13%

Every day 9%

0% 5% 10% 15% 20% 25% 30% 35% 40%

10% of oncologists responded “I prefer not to answer this question” Random National Survey of 100 General Medical Oncologists (October 2018) How often do you feel a sense of satisfaction and accomplishment with your work as an oncologist?

Never 3%

A few times a year 8%

Once a month 8%

A few times a month 28%

A few times a week 22%

Every day 31%

0% 5% 10% 15% 20% 25% 30% 35% 40% 10% of oncologists responded “I prefer not to answer this question”