2010 Oncochannel Acronyme Du Projet

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APPEL A PROJETS LABEX/ OncoChannel CALL FOR PROPOSALS DOCUMENT SCIENTIFIQUE B / 2010 SCIENTIFIC SUBMISSION FORM B Acronyme du projet/ Acronym of the Oncochannel project Titre du projet en Oncocanalopathies : approche interdisciplinaire « high- français tech » pour la médecine innovante Oncochannelopathies : high-technology interdisciplinary Project title in English approach for innovative medicine Nom/Name : PRES ULNF Coordinateur du Etablissement/institution : PRES ULNF/University of Lille projet/Coordinator of Laboratoire/Laboratory : Cell Physiology the project Numero d’unité/Unit number: Inserm U1003 Aide demandée/ 12,400,000 euros HT Requested funding X Santé, bien-être, alimentation et biotechnologies / Health, well- being, nutrition and biotechnologies □ Urgence environnementale et écotechnologies / Environnemental Champs disciplinaires urgency, ecotechnologies (SNRI) / Disciplinary □ Information, communication et nanotechnologies / Information, field communication and nantechnologies □ Sciences humaines et sociales / Social sciences □ Autre champ disciplinaire / Other disciplinary scope Domaines scientifiques/ Cellular physiology, membrane biology, biochemistry, scientific areas biophysics, nanotechnologies Participation à un ou plusieurs projet(s) « Initiatives d’excellence » (IDEX) / □ oui X non Participation in an « Initiatives d’excellence » project 1/198 APPEL A PROJETS LABEX/ OncoChannel CALL FOR PROPOSALS DOCUMENT SCIENTIFIQUE B / 2010 SCIENTIFIC SUBMISSION FORM B Affiliation(s) du partenaire coordinateur de projet/ Organisation of the coordinating partner Laboratoire(s)/Etablissement(s) Numéro(s) d’unité/ Tutelle(s) /Research Laboratory/Institution(s) Unit number Organisation reference Laboratory of Cell Physiology/ PRES/ University of U1003 PRES ULNF/University of Lille Lille1/Inserm Affiliations des partenaires au projet/Organization of the partner(s) Laboratoire(s)/Etablissement(s) Numéro(s) d’unité/ Tutelle(s)/Research Laboratory/Institution(s) Unit number Organisation reference Laboratory of Cell Physiology (LCP) U1003 Inserm - Lille 1University Glycobiology of Cell Signalling and UMR 8576 CNRS - Lille 1 University Glycopathologies (GCSG) Genetics and Evolution of Plant FRE 3268 CNRS - Lille 1 University Populations (GEPV) MALDI Imaging Team (MIT) FRE 3249 CNRS - Lille 1 University Laboratory of Biochemistry and Integrated Structural Biology UMR3078 CNRS - Lille 1 University (LBISB) NanoBioInterfaces (NBI) UMR 3078 CNRS - Lille 1 University Biostructures and drug discovery Inserm – UDSL, Institut U761 (BDD) Pasteur de Lille Interventional Therapies Assisted by U703 Inserm – Lille2 University Image and Simulation (ITAIS) 2/198 APPEL A PROJETS LABEX/ OncoChannel CALL FOR PROPOSALS DOCUMENT SCIENTIFIQUE B / 2010 SCIENTIFIC SUBMISSION FORM B 1. RESUME / SUMMARY ................................................................................ 5 2. CANDIDATURE AUX ACTIONS DU PROGRAMME INVESTISSEMENTS D’AVENIR/ APPLICATION TO THE ACTIONS OF THE PROGRAMME « INVESTISSEMENTS D’AVENIR » ........................................................................................... 9 3. ORGANISATION DU PARTENARIAT/ MANAGEMENT OF THE PARTNERSHIP .................... 9 3.1. Composition du partenariat/ Composition of the partnership ................ 9 3.2. Qualification du coordinateur de projet /Relevant experience of the project coordinator ..................................................................................... 12 Coordination of national and international projects. ......................................... 12 She developed a number of regional, national and international collaborations and successfully coordinated: two national French projects funded by ......................................................................................................... 12 - INCA (National Institute of Cancer Research) grant, 2006-2009 « The roles of trpm8 and trpv6 ion channels in prostate cancer: functional studies and molecular targeting for the elaboration of new therapeutic strategies” with 4 French laboratories CNRS UPR 9079 ; INSERM U407 ; INSERM U664 ; EA 2086; .................................................................................. 13 4. DESCRIPTION DE L’EXISTANT/ DESCRIPTION OF THE EXISTING ............................. 13 4.1. Présentation des partenaires ............................................................... 13 4.1.1 Partenaire 1/ Partner 1: PRES 13 4.1.2 Partenaire 2/ Partner 2: Natalia PREVARSKAYA 13 4.1.2.1 Recherche et innovation / Research and innovation 13 4.1.2.2 Valorisation / Exploitation of results 22 4.1.2.3 Enseignement superieur / Higher education 23 4.1.2.4 Organisation / Organisation 24 4.1.3 Partenaire 3/ Partner 3 : Jean-Claude MICHALSKI 26 4.1.3.1 Recherche et innovation / Research and innovation 26 4.1.3.2 Valorisation / Exploitation of results 28 4.1.3.3 Enseignement superieur / Higher education 28 4.1.3.4 Organisation / Organisation 28 4.1.4 Partenaire 4/ Partner 4 : Xavier VEKEMANS 30 4.1.4.1 Recherche et innovation / Research and innovation 30 4.1.4.2 Valorisation / Exploitation of results 32 4.1.4.3 Enseignement superieur / Higher education 32 4.1.4.4 Organisation / Organisation 32 4.1.5 Partenaire 5/ Partner 5 : Isabelle FOURNIER 32 4.1.5.1 Recherche et innovation / Research and innovation. 32 4.1.5.2 Valorisation / Exploitation of results 36 4.1.5.3 Enseignement superieur / Higher education 36 4.1.5.4 Organisation / Organisation 37 4.1.6 Partenaire 6/ Partner 6 : Vincent VILLERET 38 4.1.6.1 Recherche et innovation / Research and innovation 38 4.1.6.2 Valorisation / Exploitation of results 42 4.1.6.3 Enseignement superieur / Higher education 43 4.1.6.4 Organisation / Organisation 43 4.1.7 Partenaire 7/ Partner 7 : Rabah BOUKHERROUB 44 4.1.7.1 Recherche et innovation / Research and innovation 44 4.1.7.2 Valorisation / Exploitation of results 48 4.1.7.3 Enseignement superieur / Higher education 48 4.1.7.4 Organisation / Organisation 49 4.1.8 Partenaire 8/ Partner 8 : Benoit DEPREZ 52 4.1.8.1 Recherche et innovation / Research and innovation 52 4.1.8.2 Valorisation / Exploitation of results 53 4.1.8.3 Enseignement superieur / Higher education 54 4.1.8.4 Organisation / Organisation 54 3/198 APPEL A PROJETS LABEX/ OncoChannel CALL FOR PROPOSALS DOCUMENT SCIENTIFIQUE B / 2010 SCIENTIFIC SUBMISSION FORM B 4.1.9 Partenaire 9/ Partner 9 : Serge MORDON 55 4.1.9.1 Recherche et innovation / Research and innovation 55 4.1.9.2 Valorisation / Exploitation of results 58 4.1.9.3 Enseignement superieur / Higher education 58 4.1.9.4 Organisation / Organisation 59 4.2. Collaborations existantes / Existing collaborations ............................. 59 5. DESCRIPTION SCIENTIFIQUE ET TECHNIQUE DU PROJET / TECHNICAL AND SCIENTIFIC DESCRIPTION OF THE PROJECT .................................................... 60 5.1. Etat de l’art / State of the art .............................................................. 60 5.2. Objectifs du projet par rapport à l’état de l’art et liens avec la SNRI/ Objectives of the project compared to the state of the art and in relation to the SNRI .......................................................................................... 68 5.2.1 Présentation scientifique du projet de recherche/ Scientific programme 68 5.2.2 Valorisation, transfert et expertise/ Exploitation of results, transfer and expertise 82 5.2.3 Enseignement supérieur, Insertion / Higher education, Integration into the workplace 86 5.2.4 Gouvernance du Labex/ Governance 90 5.2.5 Attractivité/Attraction 93 5.3. Stratégie des établissements tutelles/ Strategy of the supervising institution ......................................................................................................... 95 5.4. Relation avec le monde socio-économique/ Connections to the socio-economic world ..................................................................................... 101 5.5. Effet d’entraînement potentiel/ Pull effect ........................................ 103 6. JUSTIFICATION SCIENTIFIQUE ET FINANCIERE DES MOYENS DEMANDES / FINANCIAL AND SCIENTIFIC JUSTIFICATION FOR THE MOBILISATION OF THE RESOURCES .......... 105 6.1. Justification des moyens demandés (sur 10 ans) / Justification for the mobilisation of the resources .................................................................... 105 6.1.1 Projet de recherche/ Research project 105 6.1.2 Projet pédagogique/ Educational project 109 6.1.3 Valorisation/ Exploitation of results 109 6.1.4 Gouvernance/ governance 110 6.2. Autres ressources / others resources ................................................ 110 7. ANNEXES / APPENDICES ........................................................................ 114 7.1. Références bibliographiques de l’etat de l’art/State of the art references ...................................................................................................... 114 7.2. Références bibliographiques des partenaires/Partners’ references ... 116 7.3. Devis/Estimate .................................................................................. 171 4/198 APPEL A PROJETS LABEX/ OncoChannel CALL FOR PROPOSALS DOCUMENT SCIENTIFIQUE B / 2010 SCIENTIFIC SUBMISSION FORM B 1. RESUME / SUMMARY Title of the project: Oncochannelopathies: high-technology interdisciplinary approach for innovative medicine. The OncoChannel Laboratory of Excellence is a research structure unique in France, centralizing intellectual and up-to-date technological expertise in the field of “Ion channels and Cancer”. Given the present achievements
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