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Frontiers in Reproductive : A COMPREHENSIVE REVIEW AND UPDATE CME Certified Activity February 28 – March 3, 2019

ARLINGTON, VA

Provided by Rutgers Robert Wood Johnson Department of , Gynecology and Reproductive Sciences Frontiers in Reproductive Endocrinology: A COMPREHENSIVE REVIEW AND UPDATE

Thursday - Sunday, February 28 - March 3, 2019 Key Bridge Marriott, Arlington, VA

Course Description his course is designed to provide the latest information on the mechanism, diagnosis and treatment of a broad range of reproductive endocrine disorders. In addition to didactic presentations, diagnostic dilemmas reflecting the breadth of reproductive endocrinology will be presented for problem solving by the faculty and participants. Interactive problem-solving exercises at the conclusion of each day will cover a broad range of endocrine disorders and . These sessions are designed to filter the evidence appropriate to each patient through an interpreted and individualized approach. In addition to diagnosis and management, emphasis will be placed on the scope and limitations of different diagnostic interventions and the use of evidence-based in deciphering infertility problems.

This course is designed as an in-depth review and update for reproductive endocrinologists who wish to sharpen and broaden their skills or for generalists who wish to increase their knowledge of reproductive endocrinology and infertility. Interactive and problem-solving sessions will be of particular value to participants who are preparing for written or oral examinations leading to board certification in . Learners from other disciplines (e.g., medical endocrinology; pediatric endocrinology) will gain insights into treatment and practice patterns in reproductive endocrinology and genetics.

Learning Objectives Upon completion of this activity, participants should be better able to: • Describe the appropriate diagnostic steps and management for a wide range of reproductive disorders. • Specify the scope, limitations, and error rates for different diagnostic interventions. • Apply the use of evidence-based medicine in decision making in infertility and other reproductive disorders. • Gain an appreciation of the appropriate summary statistics for time to pregnancy and other types of reproductive outcomes.

Target Audience This course is designed for , embryologists, geneticists, researchers, and other health professionals with interests in reproductive endocrinology, genetics, and ART. We particularly encourage clinical fellows to attend. ACTIVITY DIRECTOR

Richard T. Scott, MD, HCLD/ALD Professor and Director, Division of Reproductive Endocrinology & Infertility Department of Obstetrics, Gynecology & Reproductive Sciences Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ Professor and Fellowship Director, Division of Reproductive Endocrinology & Infertility Department of Obstetrics & Gynecology Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA Founding Partner, Reproductive Medicine Associates of New Jersey Chief Executive Officer, IVI-RMA Global

Accreditation In support of improving patient care, Rutgers Biomedical and Health Sciences is jointly accredited by the Accreditation Council for Continuing (ACCME), the Accreditation Council for Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians Rutgers Biomedical and Health Sciences designates this live activity for a maximum of 32.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Advanced Practice Nurses, Nurses, Assistants Advanced practice nurses, nurses and physician assistants may participate in this educational activity and earn a letter of attendance as AANP, ANCC and AAPA accept AMA PRA Category 1 Credits™ through their reciprocity agreements.

Method of Participation In order to meet the learning objectives and receive continuing education credit, participants are required to check in at the registration desk each day of the activity, attend the program, and complete the online evaluation form at the conclusion of the activity. A letter certifying attendance and credit verification will be emailed to participants upon completion of the online evaluation survey.

Hotel and Travel Information Just four miles from Ronald Reagan Washington National Airport and within three blocks of the DC Metro system, the Key Bridge Marriott is the perfect choice for DC vacations or business trips. Guest rooms with panoramic views of the nation’s capital and hallmark Marriott service make this Washington, DC hotel a favorite. The Key Bridge Marriott is conveniently located minutes from the Rosslyn Metro station, allowing guests easy access to some of the city’s most famous landmarks including the Iwo Jima Memorial, Arlington National Cemetery, the Pentagon, the Kennedy Center and Georgetown.

For reservations visit: https:goo.gl/1HPoZi or call 1-877-212-5752 and identify yourself with the Reproductive Endocrinology room block. The single/double occupancy rate is $201 per night, plus applicable taxes. Sleeping rooms are available until the block is sold or until February 6, 2019. Make your reservations early.

Location KEY BRIDGE MARRIOTT 1410 Lee Highway, Arlington, VA 22209 Telephone: 703-524-6400 Reservations: 877-212-5752 For room reservation and hotel information visit: https:goo.gl/1HPoZi agenda

Wednesday, February 27, 2019 5:00 - 6:00 pm Program Registration and Check-In Available

Thursday, February 28, 2019 7:00 am Registration / Continental Breakfast 7:30 am Welcome / Course Overview ...... Dr. Scott Pediatric and Medical Endocrinology 7:45 am Accelerated Sexual Development ...... Dr. Houk 8:30 am Pituitary Disorders ...... Dr. Sharma 9:15 am Delayed Sexual Development ...... Dr. Houk 10:00 am Disorders of Adrenal Function ...... Dr. Sharma 10:45 am Break - Clinical Case Unknowns / Posterboards Reproductive 11:00 am Reproductive Surgery ...... Dr. Goldberg 11:45 am Endometriosis – Mechanism of Disease and Mechanism Associated Infertility ...... Dr. Hill 12:15 pm Management of Surgical Complications in RE ...... Dr. Goldberg 1:00 pm Lunch - Clinical Case Unknowns / Slides Endocrinopathies 2:15 pm Endocrinology of Pregnancy ...... Dr. Cooper 3:00 pm Thyroid Function Tests and Dysfunction ...... Dr. Burman 3:45 pm Hyperprolactinemia ...... Dr. Lubitz 4:30 pm Vitamin D, Obesity, Celiac Diagnosis, and Reproduction . . . . Dr. Kim 5:15 - 8:00 pm Boxed Dinner - Clinical Problem Solving ...... Dr. Scott

Friday, March 1, 2019 7:00 am Registration / Continental Breakfast 7:45 am Brief Overview of the Day and Administrative Issues Hormone and Hormone Action 8:00 am Mechanism of Hormone Action for Peptides...... Dr. Mayo 8:45 am Biology of Meiotic and Mitotic Errors in Reproduction . . . . . Dr. Scott 9:30 am Mechanism of Hormone Action for Steroids ...... Dr. Mayo 10:15 am Break - Clinical Case Unknowns / Posterboards Gamete Biology and Embryo Development 10:45 am Folliculogenesis ...... Dr. Chaffin 11:30 am Spermatogenesis and Fertilization ...... Dr. Franasiak 12:15 pm Physiology of Preimplantation Embryonic Development . . . Dr. Swain 12:45 pm Lunch - Clinical Case Unknowns / Slides Implantation and Infertility and Pregnancy 2:15 pm Stem Cells for Gamete Production...... Dr. Seli 3:00 pm The Physiology and Dynamics of the Basic ART Laboratory . . . Dr. Swain 3:45 pm Vitrification...... Dr. Conaghan 4:30 pm Endometrial Receptivity and Implantation ...... Dr. Young 5:15 - 8:00 pm Boxed Dinner - Clinical Problem Solving...... Dr. Fritz agenda

Saturday, March 2, 2019 7:00 am Registration / Continental Breakfast 7:45 am Brief Overview of the Day and Administrative Issues Techniques of ART 8:00 am ...... Dr. Fritz 8:45 am ...... Dr. Hotaling 9:30 am Hirsutism and PCOS ...... Dr. Dumesic 10:15 am Break - Clinical Case Unknowns / Posterboards Statistics 10:45 am Experimental Design Considerations for Investigations Related to Infertility ...... Dr. Molinaro 11:30 am Genetic Assays: PCR, CGH, Arrays, and Next Gen. Understanding the Tests and the Information They Provide ...... Dr. Wells 12:15 pm Epidemiology and Biostats of Infertility ...... Dr. Molinaro 12:45 pm Lunch - Clinical Case Unknowns / Slides Genetics and Reproductive Anomalies 2:15 pm Gene Editing ...... Dr. Wells 3:00 pm Sexual Differentiation and Development...... Dr. Scott 3:30 pm Ambiguous Genitalia and CAH...... Dr. Goodman 4:00 pm Anomalies of the Upper and Lower Genital Tract . . . . . Dr. Goodman 5:00 -8:00 pm Boxed Dinner - Clinical Problem Solving ...... Dr. Scott

Sunday, March 3, 2019 7:00 am Registration / Continental Breakfast 7:45 am Brief Overview of the Day and Administrative Issues The Climacteric 8:00 am The Physiology of the Climacteric ...... Dr. Berga 8:45 am Evaluation and Management of Osteopenia and Osteoporosis ...... Dr. Lewiecki 9:30 am Risks and Benefits of Hormone Replacement...... TBD 10:15 am Break – Clinical Case Unknowns / Posterboards Contraception and Recurrent Loss 10:45 am An Evidence Based Approach to the Evaluation and Treatment of Recurrent Pregnancy Loss ...... Dr. Lathi 11:15 am Steroid Contraception – Pharmacokinetics, Pharmacodynamics and Clinical Application ...... Dr. Allen 12:00 pm Closing Comments and Adjournment

faculty

Rebecca H. Allen, MD, MPH Linnea R. Goodman, MD Associate Professor of Obstetrics and Gynecology, Assistant Professor, UNC Fertility, Department of and Medical Science, Warren Alpert Medical Obstetrics and Gynecology, University of North School of Brown University, Providence, RI Carolina School of Medicine, Chapel Hill, NC

Sarah L. Berga, MD Micah Hill, DO Professor and Director, Division of Reproductive Associate Professor of Obstetrics and Endocrinology and Infertility, Department of Gynecology, Uniformed Services University Obstetrics and Gynecology, University of Utah of the Health Sciences; Director, Assisted School of Medicine, Salt Lake City, UT Reproductive Technologies, Walter Reed National Military Medical Center; Program Kenneth D. Burman, MD Director, REI Fellowship, National Institutes of Professor of Medicine, Georgetown University Health, Bethesda, MD School of Medicine; Director, Endocrine Section, Medstar Washington Center; James M. Hotaling, MD, MS, FECSM Director, Endocrinology Fellowship Program, Assistant Professor of Surgery, Division of Georgetown University Hospital/MedStar , Adjunct Assistant Professor of Washington Hospital Center, Washington DC Obstetrics & Gynecology, University of Utah Health Sciences, Salt Lake City, UT; Director of Charles L. Chaffin, PhD Services, Reproductive Medicine Associate Professor of Obstetrics, Gynecology Associates of New Jersey, Basking Ridge, NJ and Reproductive Sciences, and Physiology, University of Maryland School of Medicine, Christopher P. Houk, MD, MS Baltimore, MD Associate Professor of and Medicine, Chief, Division of Pediatric Endocrinology, Joseph Conaghan, PhD Medical College of Georgia, Augusta University, Laboratory Director, Pacific Fertility Center, San Augusta, GA Francisco, CA Julia G. Kim, MD, MPH Amber R. Cooper, MD, MSCI Reproductive Endocrinology and Infertility Medical and IVF Practice Director, Vios Fertility Fellow, Reproductive Medicine Associates of Institute St. Louis; Adjunct Assistant Professor of New Jersey and Sidney Kimmel Medical College Obstetrics, Gynecology and Women’s Health, St. of Thomas Jefferson University, Basking Ridge, NJ Louis University School of Medicine, St. Louis, MO Ruth Lathi, MD Daniel A. Dumesic, MD Associate Professor of Obstetrics and Professor, Division of Reproductive Gynecology (Reproductive Endocrinology and Endocrinology and Infertility, Department Infertility), Director, Clinical Operations, Stanford of Obstetrics and Gynecology, David Geffen Fertility and Reproductive Health, Stanford School of Medicine, University of California, Los University Medical Center, Sunnyvale, CA Angeles, CA E. Michael Lewiecki, MD, FACP, FACE Jason M. Franasiak, MD, HCLD/ALD Director, New Mexico Clinical Research & Chief Medical Officer, IVI RMA America; Lead Osteoporosis Center, Director, Bone Health Physician and Laboratory Director, Reproductive TeleECHO, University of New Mexico Health Medicine Associates of New Jersey, Marlton, Sciences Center, Albuquerque, NM NJ; Assistant Professor of Obstetrics and Gynecology, Sidney Kimmel Medical College of Sara E. Lubitz, MD Thomas Jefferson University, Philadelphia, PA Associate Professor of Medicine, Division of Endocrinology, Metabolism and Nutrition, Marc A. Fritz, MD Rutgers Robert Wood Johnson Medical School, Charles Hendricks Distinguished Professor of New Brunswick, NJ Obstetrics and Gynecology, Chief, Division of Reproductive Endocrinology and Infertility, Kelly E. Mayo, PhD University of North Carolina School of Medicine, Associate Dean for Research and Graduate Chapel Hill, NC Studies, Walter and Jennie Bayne Professor of Molecular Biosciences, Weinberg College of Jeffrey M. Goldberg, MD Arts and Sciences, Northwestern University, Professor and Head of Reproductive Evanston, IL Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cleveland , Cleveland, OH faculty

Thomas A. Molinaro, MD, MSCE Dagen Wells, PhD Clinical Assistant Professor of Obstetrics, Associate Professor, Nuffield Department of Gynecology, and Reproductive Sciences, Women’s & Reproductive Health, Medical Sciences Division of Reproductive Endocrinology and Division, University of Oxford; Director, Molecular Infertility, Rutgers Robert Wood Johnson Genetic Research, IVI RMA Global, Oxford, UK Medical School; Reproductive Endocrinologist, Reproductive Medicine Associates of New Steven L. Young, MD, PhD Jersey, Basking Ridge, NJ Professor of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Emre Seli, MD University of North Carolina School of Medicine, Professor of Obstetrics, Gynecology, and Chapel Hill, NC Reproductive Sciences at Yale School of Medicine, New Haven, CT; Research Director, IVI RMA Global, Basking Ridge, NJ All individuals who affect the content of continuing education activities are required to disclose to the Susmeeta T. Sharma, MD, MHSc audience any real or apparent conflict of interest Director, Pituitary Endocrinology, MedStar related to the activity. The activity faculty are Pituitary Center, MedStar Washington Hospital further required to disclose discussion of off-label/ Center, Washington, DC investigational uses in their presentations. These disclosures will be made to the audience at the Jason Swain, PhD, HCLD time of the activity. Corporate Laboratory Director, CCRM IVF Rutgers reserves the right to modify program Network, Lone Tree, CO content, faculty and program activities. It also reserves the right to cancel the activity if necessary. If the activity is cancelled, liability is limited to the registration fee.

registration

Registration Fees $650 Full Registration $450 Fellows-in-Training, Residents, Trainees, Students * * Registration must be accompanied by program director’s letter confirming fellow/resident/ trainee/student status. Please upload your letter when registering or fax to 973-972-3371. Registration fee includes all plenary sessions, four continental breakfasts, three lunches, three boxed dinners, refreshments, continuing education credits, and course material. Registration can only be accepted through our secure on-line website. Note: Please register early. Space for this program is limited. Online registration will close on February 20, 2019 or earlier if seating capacity is reached. On-site registration will be accommodated on a space available basis. Please be sure to make hotel reservations soon after you register. To register: https://rutgers.cloud-cme.com/2019Frontiers Please note that this is a new registration system and you must create a new account in order to register. Confirmation Once registered, you will receive a confirmation message and additional information to assist you with your plans to participate in the activity. Cancellation/Refund A full refund, less a $50 cancellation fee, will be granted if notice is received no later than February 20, 2019. Refunds will not be issued for any cancellation received after February 20, 2019 and cannot be given for “no shows.” To cancel, please contact CCOE by telephone at 973- 972-4267 or by email at [email protected] For Additional Information For additional information, questions, concerns, or if you require special arrangements to attend this activity, please contact CCOE by telephone at 973-972-4267 or by email at [email protected]. Activity Code: 19MR01 To register visit: https://rutgers.cloud-cme.com/2019Frontiers Non-Profit Frontiers inReproductive Endocrinology: Organization Department ofObstetrics,Department Gynecology &Reproductive Sciences

Thursday -Sunday, February 28-March 3, 2019 U.S. Postage

This activity is supported in part by aneducational grant from inpart issupported This activity PAID A COMPREHENSIVE ANDUPDATE REVIEW Rutgers University Center for Continuing and Outreach Education Rutgers Robert Rutgers Robert Wood School, Johnson Medical Key Bridge Marriott, Arlington, VA 30 Bergen Street • ADMC 7 • Newark, NJ 07107-3000 EMD Serono, Inc. CME Certified CME Certified Activity Provided by:

For more information and registration visit: https://rutgers.cloud-cme.com/2019Frontiers