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A Meta-Analysis on Uterine Transplantation: Redefining the Limits of Reproductive Surgery

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A Meta-Analysis on Uterine Transplantation: Redefining the Limits of Reproductive Surgery REVIEW ARTICLE SILVA AND CARVALHO A meta-analysis on uterine transplantation: Redefining the limits of reproductive surgery ANA FLÁVIA GARCIA SILVA1*, LUIZ FERNANDO PINA CARVALHO2 1BS – Medical Student, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil 2PhD – Department of Gynecology and Obstetrics, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil SUMMARY In September 2014, the first baby grown in a transplanted uterus was born, which represented an astonishing scientific progress that will mark the history of hu- man reproduction. The recipient was a 32-year-old woman with Rokytanski syn- drome who became pregnant after a successful embryo transfer and had an un- Study conducted at Faculdade de eventful pregnancy, giving birth to a healthy newborn and marking the beginning Medicina, Universidade de São Paulo, of a new era. Patients who do not have a uterus or have a dysfunctional uterus São Paulo, SP, Brazil now have the chance of dreaming with pregnancy and motherhood. Combining Article received: 5/30/2015 principles of solid organ transplantation and techniques of human reproduc- Accepted for publication: 6/21/2015 tion, uterus transplantation is the first ephemeral transplant performed in or- *Correspondence: der to promote reproductive potential of women and may be removed after suc- Address: Rua Oscar Freire, 2121, apto. 1107, Pinheiros cessful pregnancy. Worldwide, 11 uterine transplantations were performed in São Paulo, SP – Brazil patients. Of these, seven maintained their reproductive potential, with viable Postal code: 05409-011 [email protected] transplanted uteri and regular menstrual cycles. http://dx.doi.org/10.1590/1806-9282.62.05.474 Keywords: reproduction, reproductive techniques, transplantation. INTRODUCTION Uterus transplantation consists of a complex treat- In 2014, the first baby of a transplanted uterus was born, ment that combines principles of solid organ transplan- surpassing another limit of reproductive surgery. This tation and assisted reproduction techniques. Further- was a scientific breakthrough that will be remembered in more, conducted with the aim of promoting fertility and the history of human reproduction and transform the thus improve the quality of life of the patient, and not lives of many women who dream of being a mother. Med- necessarily to extend it, this is the first ephemeral trans- ically speaking, this would be impossible for patients who plantation, i.e., the transplanted organ may be removed were born without a uterus or had them surgically re- after the treatment’s objectives are achieved.3 moved. But now, there is hope. Currently, patients without a uterus or those who DEVELOPMENT OF UTERUS TRANSPLANTATION: have dysfunctional uteri face great difficulties when they DESCRIBING THE SURGICAL TECHNIQUE wish to become pregnant. The options available include The donor’s surgery begins with a midline incision ex- adoption and surrogacy, which are subject to ethical, psy- tending from the navel to the pubic symphysis. Then, the chological and legal dilemmas. uterus and vascular pedicles are dissected, that is, uter- In this sense, uterine transplant appears as a revolution- ine vessels and a segment of the internal iliac vessels bi- ary form of treatment for uterine infertility, which occurs laterally. For better fixation in the receiver’s pelvis, parts in patients who have severe intrauterine adhesions, those of the round ligament, uterosacral ligament and the peri- presenting Müllerian anomalies, or who underwent prior toneum are also removed. The lateral walls of the pelvis hysterectomy. For approximately 9.5 million women in the are dissected, and the ureters are completely separated United States, it is the only treatment option that would al- from the cervix and the uterine vessels. The vagina is then low these patients to experience pregnancy and to give birth dissected 10-15 mm distal to the vaginal fornix. Finally, to their children.1 In Brazil, where about 100,000 hysterec- the vessels are clamped and the blood supply is interrupt- tomies are performed annually,2 the scenario is similar. ed. Then, the uterus is removed and transported to the 474 REV ASSOC MED BRAS 2016; 62(5):474-477 A META-ANALYSIS ON UTERINE TRANSPLANTATION: REDEFINING THE LIMITS OF REPRODUCTIVE SURGERY table, where it is initially flushed with heparinized saline The receiver’s vaginal walls are opened using a longi- solution, followed by cold preservation solution. The uter- tudinal 40 mm incision, and the vaginal portion of the us is kept on ice until the time of transplantation.4 graft is anastomosed to the Douglas’ cul-de-sac. The uter- Likewise, the receiver’s surgery begins with a subum- us is fixed in anatomical position by binding of the su- bilical midline incision. First, the vaginal walls are sepa- tures pre-positioned to their respective ligaments, and by rated from the bladder and rectum, and sutures are at- superimposing the graft’s peritoneum on the recipient’s tached to the round ligament, uterosacral ligament, bladder.4 uterine rudiment (patients with Müllerian anomaly), or The receiver’s anesthesia and surgery are, in general, paravaginal connective tissue (patients with cervical can- identical to the donor’s. The pre-transplant evaluation of cer) for later transplant fixation. The external iliac vessels patients has been extensively described for solid organ are then dissected bilaterally. The uterus is brought into transplantation. The standard protocol published in im- the room, still on ice, and placed in the receiver’s pelvis munosuppression literature consists of a triple regimen in an anatomical position. End-to-side vascular anasto- of tacrolimus, azathioprine and corticosteroids, which ap- moses are performed between the vessels of the graft and pears to be safe during pregnancy. The cases of mild rejec- the external iliac vessels, after which the clamping of the tion were successfully treated with pulse steroid therapy.4 external iliac vein is released. A mannitol intravenous bo- lus is administered immediately before the arterial clamp- RESULTS ing is released, and the systolic blood pressure is moni- Worldwide, 11 uterine transplantations were performed tored and maintained above 100 mmHg. After completion in patients (Figure 1). In 2000, the first case of uterine of all vascular anastomoses, blood flow in uterine vessels transplant was performed in Saudi Arabia in a 26 year- is quantified using a Doppler probe placed around the -old patient with a history of hysterectomy due to post- uterine arteries.4 partum hemorrhage, who received the organ from a liv- FIGURE 1 On the map, the three centers performing uterus transplantation in humans in the world: Saudi Arabia (N=1) in 2000, Turkey (N=1) in 2011, and Sweden (N=9) since 2012. X: Transplant with complications leading to hysterectomy; : Transplants that maintain reproductive potential. REV ASSOC MED BRAS 2016; 62(5):474-477 475 SILVA AND CARVALHO ing donor. Three months after transplantation, the days, and cesarean delivery was performed. A newborn transplanted uterus developed progressive necrosis, and with normal weight for gestational age and Apgar scores hysterectomy was performed.5 The second case occurred 9, 9, 10 was born in September 2014.3 in 2011 in Turkey, in a patient with Rokytanski syndrome who received the organ from a deceased donor. The trans- CONCLUSION planted uterus was viable and the patient underwent em- After 15 years of research, the first baby resulting from a bryo transfer 18 months after the operation, having pre- transplanted uterus was born in 2014. Uterus transplan- sented two pregnancies spontaneously aborted before 6 tation is a revolutionary new option for patients with weeks of gestational age (GA).6 uterine infertility, most commonly caused by Rokytans- Initiated in 2012 in Sweden by the group of Dr. ki syndrome, previous hysterectomy, or severe intrauter- Brannstrom, the clinical trial on uterus transplant was ine adhesions. It is the only treatment that enables the responsible for the following nine cases in which nine pa- experience of pregnancy for women with such conditions. tients, eight suffering from Rokytanski syndrome and Since this is still an experimental procedure, the risks and one with prior hysterectomy due to cervical cancer, re- benefits, as well as medical and legal complexities should ceived transplants from living donors. Two patients un- be discussed regarding the three parties involved: the do- derwent hysterectomy during the first few months after nor, the recipient and the fetus. Possible complications transplantation due to uterine artery thrombosis and se- include rejection, infection and necrosis of transplanted vere intrauterine infection, respectively. The remaining uterus, and need for hysterectomy may occur. These com- seven patients started to have menstrual cycles about 2 plications can be especially critical if they occur during to 3 months after transplantation, and maintained reg- pregnancy, and should be addressed in the preoperative ular menstrual cycles during the first year. Transplants counseling. remained viable and, to date, the seven patients have re- Furthermore, since the surgery involves section of productive potential (Table 1).4 pelvic nerves, it is unclear how the pregnancy will be ex- One of the cases in the clinical trial, a 35 year-old pa- perienced by the recipient, since many sensations of preg- tient with Rokytanski syndrome that in 2013 received the nancy and labor may be perceived differently.7 Thus, the uterus of a donor aged 61, resulted in pregnancy and in case of the aforementioned patient will be valuable, al- the first baby born after uterus transplantation and suc- though a greater number of cases is necessary for better cessful embryo transfer. The transplanted uterus had only understanding of the perinatal period. one episode of mild rejection, reversed by corticosteroids. The limited number of transplants performed does Pregnancy had no complications, with a benign fetal eval- not allow the conclusion that there are differences in re- uation and uneventful throughout pregnancy.
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