Monoclonal Antibody to CD267 / TACI - Azide Free

OriGene Technologies, Inc. OriGene Technologies GmbH

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AM26557AF-N Monoclonal Antibody to CD267 / TACI - Azide Free

Alternate names: TNFRSF13B, Transmembrane activator and CAML interactor, Tumor necrosis factor receptor superfamily member 13B Quantity: 0.1 mg Concentration: 1.0 mg/ml Background: CD267, also known as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) or TNFRSF13B, is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF/CD257) and as a proliferation-inducing ligand (APRIL/CD256). BAFF and APRIL bind both TACI and BCMA (B cell maturation Ag/CD269), with BAFF additionally and exclusivel y binding the BAFF receptor (BAFF-R/CD268) while APRIL can also bind to heparin sulfate proteoglycan s (HSPG). TACI is expressed on B cells and activated T cells. BC MA is exclusively expressed on B cells, whereas BAFF-R is expressed mainly on B cells but also on T cells. It is reported that mutations of CD267/TACI are showed in patients with IgA deficiency and common variable immunodeficiency (CVID). Sakurai et al ., reported that TACI positively regulated APRIL-induced IgA production in collaboration with HSPG and TACI negatively regulated BAFF-induced B-cell proliferation and production of IgA and IgG. Uniprot ID: O14836 NCBI: NP_036584.1 GeneID: 23495 Host / Isotype: Mouse / IgG2a Clone: 11H3 Immunogen: Human TACI full-length cDNA-transfected cells Format: State: Liquid Ig fraction Purification: Protein A agarose Buffer System: PBS containing 50% glycerol, pH 7.2. No preservative is contained. Applications: Flow cytometry: 10 µg/ml (final concentration). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody reacts with CD267 antigen. Clone 11H3 has an agonistic activity and it doesn’t block binding of BAFF to TACI. Species Reactivity: Tested: Human Add. Information: This product was originally produced by MBL International. Storage: Upon receipt, store (in aliqouts) at -20 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch. General Readings: 1. Sakurai, D., et al., Blood 109 , 2961-2967 (2007). 2. Hase, H., et al., Blood 103, 2257-2265 (2004).

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130815 1 / 2 AM26557AF-N: Monoclonal Antibody to CD267 / TACI - Azide Free

Pictures: Flow cytometric analysis of CD267 expression on transfectant. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26557AF-N to the cells.

Flow cytometric analysis of CD267 expression on EBV-LCL cells. Shaded histogram indicates the reaction of isotypic control to the cells. Open histogram indicates the reaction of AM26557AF-N to the cells.

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130815 2 / 2