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JCTH Associate Editors Editorial Board OWNED by the SECOND AFFILIATED HOSPITAL Dr JCTH Associate Editors Editorial Board OWNED BY THE SECOND AFFILIATED HOSPITAL Dr. Timothy Billiar Prof. Lungen Lu Dr.Subrat Kumar Acharya Prof. Ying Han Dr. Qingfeng Sun OF CHONGQING MEDICAL UNIVERSITY F-1281 Presbyterian University Hospital Shanghai Jiaotong University School of New Delhi, India Xi'an, China Wenzhou, China Pittsburgh, USA Medicine Dr. Piero Luigi Almasio Prof. Saeed Hamid Prof. Gloria Taliani Shanghai, China Dr. John Birk Palermo, Italy Karachi, Parkistan Roma, Italy Editors-in-Chief University of Connecticut Dr. John Luk Farmington, USA Johnson & Johnson Medical Ltd. Dr. Costica Aloman Dr. Kazuhiko Hayashi Prof. Hong Tang Shanghai, China New York, USA Nagoya, Japan Chengdu, China Prof. Hong Ren Prof. Limin Chen Peking Union Medical College Prof. Yen-Hsuan Ni Prof. Gianfranco D. Alpini Dr. Wasim Jafri Dr. Claudio Tiribelli General Editor-in-Chief Chengdu, China National Taiwan University Bryan, USA Aga Khan, Parkistan Trieste, Italy The Second Affiliated Hospital of Chongqing Medical University, China Prof. Chengwei Chen Taipei, Taiwan Dr. Masahiro Arai Dr. Di Jia Prof. Zhengkun Tu Dr. Harry Hua-Xiang Xia Nanjing Military Command Prof. Kannika Phornphutkul Tokyo, Japan Boston, USA Changchun, China Shanghai, China Chiang Mai University Editor-in-Chief Dr. Gyorgy Baffy Dr. Wei Jia Dr. Adriana Vince Chiangmai, Thailand Novartis Pharmaceuticals Corporation, USA Prof. Aziz A. Chentoufi Boston, USA Kunming, China Zagreb, Croatia Medicine King Fahad Medical College Dr. Kittichai Promrat Dr. Savino Bruno Dr. Jiaji Jiang Dr. Farzin Roohvand Prof. George Y. Wu Riyadh, Saudi Arabia Alpert Medical School of Brown University Milan, Italy Fuzhou, China Paris, France/Iran Comprehensive Editor-in-Chief Prof. Xiaoguang Dou Providence, USA University of Connecticut Heath Center, USA Shengjing Hospital of China Medical Prof. Cheng Qian Dr. Chalermrat Bunchorntavakul Dr. Jianning Jiang Dr. Fusheng Wang University Third Military Medical University Southwest Bangkok, Thailand Nanning, China Beijing, China Shengyang, China Hospital Dr. Wendy Cao Dr. Anastasios Koulaouzidis Prof. Genshu Wang Chongqing, China Managing Editors Prof. Zhongping Duan New York, USA Edinburgh, United Kingdom Guangzhou, China Affiliated Beijing You'an Hospital of Capital Dr. Arielle Rosenberg Prof. Mark J. Czaja Dr. Ashish Kumar Dr. Leyi Wang Medical University University Paris Descartes Dr. Huaidong Hu Beijing, China Paris, France New York, USA New Delhi, India Columbus, USA The Second Affiliated Hospital of Chongqing Prof. Naoya Sakamoto Dr. Andres Cardenas Prof. Laurentius A. Lesmana Prof. Benjamin Wong Medical University, China Dr. Jean-François Dufour University of Bern Hokkaido University Barcelona, Spain Jakarta, Indonesia Hong Kong, China Sapporo, Japan Dr. Zhi Peng Bern, Switzerland Prof. Flair José Carrilho Dr. Bing Liu Prof. Catherine Y. Wu The Second Affiliated Hospital of Chongqing Prof. Marko Duvnjak Dr. Michael Schilsky São Paulo, Brazil Guangzhou, China Farmington, USA Medical University, China Yale University Clinical Hospital Centre “Sestre milosrdnice” Dr. Phunchai Charatcharoenwitthaya Dr. Rohit Loomba Dr. Yongning Xin Zagreb, Croatia New Haven, USA Bangkok, Thailand San Diego, USA Qingdao, China Prof. Faripour Forouhar Dr. Tawesak Tanwandee Prof. Zhi Chen Prof. Eduardo Martinez Prof. Huiping Yan University of Connecticut Siriraj Hospital, Mahidol University Bangkok, Thailand Contact information Farmington, USA Hangzhou, China Hidalgo, Mexico Beijing, China Prof. Lai Wei Dr. Silvia Degli-Esposti Prof. Jane McKeating Prof. Ming Yan Dr. Johannes Haybaeck Peking University People’s Hospital +86 23 63727251 Medical University Graz Providence, USA Birmingham, United Kingdom Shangdong, China Telephone Beijing, China Graz, Austria Prof. Lei Dong Prof. Albert D. Min Prof. Eric M. Yoshida Fax +86 23 63701383 Prof. Jinlin Hou Dr. Xuefeng Xia Xi’an, China San Diego, USA Vancouver, Canada Nanfang Hospital of Southern Medical The Methodist Hospital Research Institute [email protected] Dr. Yu-Chen Fan Prof. Ming Kuang Dr. Hong You E-mail University Houston, USA Jinan, China Guangzhou, China Beijing, China Guangzhou, China Dr. Kecheng Xu Address 74 Linjiang Road, Dr. Peter Ferenci Dr. Mohamed Othman Prof. Cihan Yurdaydin Yuzhong District, Prof. Keqin Hu Fuda Cancer Hospital Heidelberg, Austria El Paso, USA Ankara, Turkey Chongqing, P. R. China, University of California Guangzhou, China Orange, USA Prof. Eduardo Fernández-Martínez Prof. Piero Portincasa Prof. Mikio Zeniya 400010 Prof. Man-Fung Yuen Hidalgo, Mexico Bari, Italy Tokyo, Japan Prof. Ailong Huang The University of Hong Kong Chongqing Medical University Queen Mary Hospital Dr. Heather L. Francis Dr. Farzin Roohvand Prof. Xinxin Zhang Chongqing, China Hong Kong, China Bryan, USA Tehran, Iran Shanghai, China Dr. Hitoshi Ikeda Dr. Jinxiang Zhang Dr. James Y.Y. Fung Dr. Regina Santella Dr. Yuanyuan Zhang The University of Tokyo Tongji Medical College Hong Kong, China New York, USA Chengdu, China Tokyo, Japan Huazhong University of Science and Prof. Paul J. Gaglio Dr. Ke-Qing Shi Prof. Yuexin Zhang Prof. Jidong Jia Technology Capital Medical University Wuhan, China New York, USA Wenzhou, China Xinjiang, China Beijing, China Prof. Dazhi Zhang Ping Gu Prof. Gamal Shiha Prof. Jingmin Zhao Prof. Yong Liao The Second Affiliated Hospital of Chongqing New York, USA Mansoura, Egypt Beijing, China The Second Hospital Affiliated Chongqing Medical University Prof. Steven-Huy Bui Han Dr. Robert Smolic Dr. Minghua Zheng Chongqing, China Medical University Los Angeles, USA Osijek, Croatia Wenzhou, China Chongqing, China Dr. Lanjing Zhang Prof. Tao Han Dr. Martina Smolic Dr. Senlin Zhu Dr. Joseph Lim University Medical Center of Princeton Plainsboro, USA Tianjin, China Osijek, Croatia Guangzhou, China Yale University New Haven, USA JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY Call for papers JCTH is a new, comprehensive specialist journal focusing on the recent progress in clinical and basic research with direct applications to clinical management of liver diseases. The studies published in JCTH will represent the most current trends in the field of hepatology, highlighting the topically relevant subjects of nations worldwide. Publications in JCTH will be presented in formats that emphasize clarity of the study’s objectives and implications of its findings, using high quality visual aids to enhance the manuscript’s esthetic appeal as well as its impact. For our upcoming issue, we encourage you and your group to submit original articles that showcase your work in hepatology and topically relevant reviews to promote our readers’ understanding of the field. CONTENTS 2014 2(2):65–141 Original Article Patient Characteristics, Safety, and Tolerability With Telaprevir Treatment for HCV in the Clinic: a Retrospective, Multicenter Study Steven L. Flamm, Paul J. Pockros, Leif Bengtsson and Mark Friedman . ..........................65 Review Articles An Update on Treatment of Drug-Induced Liver Injury Christin Giordano, John Rivas and Xaralambos Zervos .........................................74 Traditional Chinese Medicine Induced Liver Injury Rolf Teschke .......................................................................80 Hepatotoxicity Secondary to Chemotherapy Alla Grigorian and Christopher B. O’Brien . .................................................95 Pathology of Alcoholic Liver Disease Romulo Celli and Xuchen Zhang . ......................................................103 Clinical Application of Transient Elastography in the Diagnosis of Liver Fibrosis: an Expert Panel Review and Opinion Expert Panel on Liver Stiffness Measurement ...............................................110 Maternal-Fetal Hepatitis E Transmission: Is It Underestimated? Maysaa El Sayed Zaki, Mohammed Magdy Abd El Razek and Hassan Magdy Abd El Razek ............117 Management of Hepatitis C Before and After Liver Transplantation in the Era of Rapidly Evolving Therapeutic Advances Chalermrat Bunchorntavakul and K. Rajender Reddy .........................................124 Interaction Between the Neglected Tropical Disease Human Schistosomiasis and HCV Infection in Egypt: a Puzzling Relationship Mahmoud M. Bahgat ................................................................ 134 Original Article Patient Characteristics, Safety, and Tolerability With Telaprevir Treatment for HCV in the Clinic: a Retrospective, Multicenter Study Steven L. Flamm1, Paul J. Pockros2, Leif Bengtsson3 and Mark Friedman3 1Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA; 2Scripps Clinic and Scripps Translational Science Institute, La Jolla, California, USA; 3Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, USA Abstract Introduction Background and Aims: There is a paucity of information Randomized, controlled clinical studies are considered the regarding similarities and differences between patients from gold standard for the evaluation of efficacy, safety, and the phase 3 studies of telaprevir and those receiving tolerability of pharmaceutical drugs.1,2 Such studies allow telaprevir in clinical practice. Methods: This retrospective for rigorous assessment of these parameters in controlled chart review evaluated baseline characteristics and follow-up settings that prevent potential confounds when observing a safety and tolerability data for patients with hepatitis C virus drug’s effect(s).3 These studies, however, have important (HCV) infection treated with telaprevir and peginterferon alfa characteristics that
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