Official Journal of the American Gastroenterological Association Editorial Stall Nicholas I Ann Marie Link, Managing Editor Mayo Foil Shirley A. Hinze, Assistant ManagmgEdifidr ,200 First 5 RaLynn J. Petersen, Editorial Assistent Rochester, Barbara Plenge, Editorial Assistant

Joseph R. LaurenceJ. Miler University Mayo Clinic Minneapo] Rochester, Minnesota C. Richard Jorge Rakela University Mayo Clinic Ana Arboj Rochester, Mimesota Eugene B. v Joseph H Sszursewski iviayu v^iimc University of Chicago Mayo Clinic Rochester, Minnesota Chicago, Illinois Rochester, Mimesota Richard H. Hunt McMaster University Hamilton, Ontario, Canada Special Section Editors This Month in GASTROENTEROLOGY Editor Selected Summaries Editor Book Review Editor J. Thomas LaMont Mark Feldman Jonathan E. Gain , Boston, Massachusetts Dallas, Texas Rochester, Minnesota Chairman of Editorial Board Jerry S. Trier Boston, Massachusetts Editorial Board Officers of the American Gastroenterological Association Dennis J. Ahnen, Denver, Colorado mm ; Robert N. Berk, La Jolla, California President David Brenner, La Jolla, California Walter J. Hogan ^eg^iy B. Bulkley, Baltimore, Maryland Milwaukee, Wisconsin Helena). Cooke, Columbus, Ohio \ Maile Of*.Debas, San Francisco, California President-Elect *,Vfälliatn G Duane, Minneapolis, Minnesota Don W. Powell %Cn%rle$;0. Elson III? Birmingham, Alabama Galveston, Texas ,01atidia*Fiocchi, Cleveland, Ohio . Jplsn G, Forte, Berkeley, California Vice President jfpj^ri Ö: Furness, Parkville, Victoria, Australia John H. Walsh Jeffrey % Gordon, St. Louis, Missouri Los Angeles, California

»Rpdger C. Haggitt, Seattle, Washington Gregory L. Eastwood ^a^rhes D. Jamieson, New Haven, Connecticut Augusta, Georgia Martin F; Kagnoff, La Jolla; California Juan BLfMalagelada, Barcelona, Spain . Secretary-Elect \l^arian^. Neutra, Boston, M^achusetts Thomas A. Brasitus , ;fchung Owyang, Ann Arbor, Michigan Chicago, Illinois JDavid H. Perlmutter, St* Louis, Missouri \ Da&triC Podolsky, Boston, Massachusetts Treasurer -ll, Los Angeles, California

ISteyen Strasber& St Louis, Missouri x mm Members of the Council -Frederick J: Suchy, New Haven, Connecticut J^eslie A?Turnberg, Salford, England David H. Alpers, St. Louis, Missouri Sidney Cohen, Philadelphia, Pennsylvania W. B. Saunders Company Stanley B. Goldberg, Berkeley, California f Curtis Center H J. Thomas LaMont, Boston, Massachusetts jndence Square West Tadataka Yamada, Ann Arbor, Michigan iladelphia, Pennsylvania 19106-3399 GASTROENTEROLOGY 1993; 104:1894

NOTICES Brief notices of interest to a substantial number of our readers are published in GASTROENTEROLOGY. Notices must be typewritten double-spaced and submitted in triplicate. Notices received less than 5 months before the issue of publication cannot be guaranteed an appropriate publication date. Direct all Notices to: Nicholas F. LaRusso, M.D., Editor, GASTROENTEROLOGY, Mayo Foundation, 200 First Street S.W., Rochester, Minnesota 55905.

FALK SYMPOSIA NOS. 72 AND 73 SECOND ANNUAL SCIENTIFIC MEETING OF THE DYSPHAGIA RESEARCH SOCIETY Symposium 72, "IV International Symposium on Inflammatory Bowel Diseases," will take place September 6-8, 1993. "Short Abstracts of scientific works in physiology/pathophysiology of Chain Fatty Acids," symposium 73, will be held September 9-11, swallowing and dysphagia-related topics are invited for presenta• 1993. Both congresses will be in Strasbourg, Germany. tion. This meeting will be held October 22-24, 1993, in Lake Contact: Falk Foundation e.V., Leinenweberstraße 5, W-7800 Geneva, Wisconsin. Deadline for submission of abstracts is Sep• Freiburg, Germany; or call (49) 761-13034-0; or fax (49) 761- tember 1, 1993. 13034-59. Contact: Dysphagia Research Society, Administrative Office, c/o Reza Shaker, M.D., GI Section/11 IC, VA Medical Center, SECOND INTERNATIONAL CONFERENCE 5000 West National Avenue, Milwaukee, Wisconsin 53295; or call OF GASTROENTEROLOGY (414) 384-2000, ext 6943; or fac (414) 384-8480. This conference will be held in Hong Kong August 27-29, 1993, and in Chengdu August 27-September 2, 1993. For information and application, please contact: Conference Se• cretariat, Room 1611-13, World Finance Center, North Tower, 14TH INTERNATIONAL CONGRESS OF LYMPHOLOGY Harbour City, Kowloon, Hong Kong; or call (852) 736-7837; or The following conferences will be held in Washington, D.C. fax (852) 376-0329. "Frontiers in Lymphology" (Part 1) will be held September 20-21, 1993, and "Lymphology in 1993" (Part 2) will be held September INTERNATIONAL CONFERENCE ON 22-26, 1993. ENDOTOXINS AMSTERDAM IV Contact: 14th ICL Congress Secretariat, c/o M. H. Witte, M.D., This conference will take place in Amsterdam, The Nether• Attention: Grace Wagner, Program Coordinator, Department of lands, August 17-20, 1993. Surgery/General, University of Arizona College of Medicine, 1501 Contact: Dr. S. j. H. van Deventer, Conference Secretary, De• North Campbell Avenue, Tucson, Arizona 85724; or call (602) partment of Hematology (G-l-112), Academic Medical Center, 626-6118; or fax (602) 626-0822. Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; or call (31) 20-5669111; or fax 09 (31) 20-5664440.

ASPEN BILE ACID/CHOLESTEROL/ THE AGA 1993 FALL POSTGRADUATE COURSE LIPOPROTEIN CONFERENCE The topic for this course is "A Comprehensive Update and Re• view of Gastroenterology and Hepatology." It will be held Sep• This conference will take place August 21-24, 1993 in Aspen, tember 9-12, 1993, in Chicago, Illinois. CME Credit (24.5 hours, Colorado. Deadline for applications is May 30, 1993. Category I) will be offered. Contact: Mrs. Bernie C. Kern, 501 Madison Street, Denver, Col• Contact: Registration Manager, SLACK Incorporated, 6900 orado 80206; or call (303) 325-0330; or fax (303) 355-0739. Grove Road, Thorofare, New Jersey 08086-9447; or call (609) 848-1000; or fax (609) 848-5274.

THE LEEDS COURSE IN CLINICAL NUTRITION 15TH ANNUAL ASPEN CONFERENCES ON PEDIATRIC DISEASE This event will take place September 7-10, 1993, in Leeds, En• gland. This conference will be held July 26-30, 1993, in Aspen, Colo• Contact: Mrs. Hilary L. Helme, Dept of Continuing Profes• rado. Twenty-five hours of Category I credit will be offered. sional Education, Continuing Education Building, Springfield Contact: Institute for Pediatric Medical Education, 6604 Lan- Mount, Leeds LS2 9NG, England; or call (44) 532-333233. don Lane, Bethesda, Maryland 20817; or call/fax (301) 229-8338. AUTHOR INDEX TO VOLUME 104

Abei M, Kawczak P, Nuutinen H, Langnas Alvarez F. See Yamamoto AM Arroyo V A, Svanvik j, Holzbach RT. Isolation Ambroze WL Jr, Pemberton JH, Dozois See Asbert M and Characterization of a Cholesterol RR, Carpenter HA, O'Rourke JS, See Badalamenti S Crystallization Promoter From Hu• Ilstrup DM. The Histological Pattern Arsenault P. See Menard D man Bile, 104:539 and Pathological Involvement of the Asako H, Wolf RE, Granger DN. Leuko• Abramowich D. See Broide E Anal Transition Zone in Patients cyte Adherence in Rat Mesenteric Abramowsky C. See Banwell JG With Ulcerative Colitis, 104:514 Venules: Effects of Adenosine and Abrignani A. See Botarelli P Amorosi A. See Bechi P Methotrexate, 104:31 Achord JL. How Gastric Acid May Get to Andersen PK. See Lombard M Asbert M, Gines A, Gines P, Jimenez W, Be There. Comment, 104:l878-ss Ando H, Miyoshi Y, Nagase H, Baba S, Claria J, SaloJ, Arroyo V, Rivera F, Adenis A, Wallaert B, Colombel J-F, Nakamura Y. Detection of 12 Germ- Rodes J. Circulating Levels of En• Cortot A, Marchandise X, janin A, Line Mutations in the Adenomatous dothelin in Cirrhosis, 104:1485 Hällgren R. Intestinal Involvement Polyposis Coli Gene by Polymerase Asbun HJ, Rossi RL, Heiss FW, Shea JA. in Sarcoidosis, 104:947-c Chain Reaction, 104:989 Acute Relapsing Pancreatitis as a Adler G. See Büchler M Andreu D. See Gambias G Complication of Papillary Stenosis Adler R. See Ilan Y Andreu M, Sola R, Sitges-Serra A, Alia C, After Endoscopic Sphincterotomy, Adrian TE. See Banwell JG Gallen M, Vila MC, Coll S, Oliver 104:1814-cr Afdhal NH, Niu N, Gantz D, Small DM, MI. Risk Factors for Spontaneous Attwood SEA, Stephens RB. Appendec• Smith BF. Bovine Gallbladder Mucin Bacterial Peritonitis in Cirrhotic Pa• tomy—Will the Laparoscope Reign? Accelerates Cholesterol Monohydrate tients With Ascites, 104:1133 Reply, 104:936-ss Crystal Growth in Model Bile, Angelico M, Carli L, Piat C, Gentile S, Auricchio S. See Maiuri L 104:1515 Rinaldi V, Bologna E, Capocaccia Agarwal DK, Mukhopadhyay DK. Biliary L. Isosorbide-5-Mononitrate Versus Acidification and Gallstone Calcifi• Propranolol in the Prevention of Baba S. See Ando H cation, 104:1885-c First Bleeding in Cirrhosis, 104:1460 Bacon BR, Di Bisceglie AM. Aspartate Ahnen D. See Wright NA Anti M, Marra G, Percesepe A, Armelao Aminotransferase and Iron Status- Alsenberg J. See Sperber K F. (0-3 Fatty Acids and Bowel Lack of Support for Covariation. Alam Afridi S, Shaw-Stiffel TA. Evolu• Cancer. Reply, 104:1240-c Reply, 104:665-c tion of Barrett's Esophagus: The Jury Anton PA. See Shanahan F Badalamenti S, Gines P, Arroyo V. Renal Is Still Out, 104:1236-c Apple FS. Absence of False Elevations Effects of Aminoacid Administration A1 biliös A, Colombato LA, Lee F-Y, With Kodak Ektachem Lipase. in Cirrhosis, 104:1886-c Groszmann RJ. Octreotide Amelio• Reply, 104:1580-c Badger TM. See Hakkak R rates Vasodilatation and Na+ Reten• Arai M, Mochida S, Ohno A, Ogata I, Badsberg JH. See Lombard M tion in Portal Hypertensive Rats, Fujiwara K. Sinusoidal Endothelial Baker RA. See Padbury RTA 104:575 Cell Damage by Activated Macro• Balart LA. See Lefkowitch JH Albrecht j. See Lefkowitch JH phages in Rat Liver Necrosis, Balart LA, Perrillo R, Roddenberry J, AlexeyefT MA. See St. John DJB 104:1466 Regenstein F, Shim K-S, Shieh YSC, Alia C. See Andreu M Argenzio RA, LecceJ, Powell DW. Pros• Taylor B, Dash S, Gerber MA. Hep• Allan CH, Mendrick DL, Trier JS. Rat tanoids Inhibit Intestinal NaCl Ab• atitis C RNA in Liver of Chronic Intestinal M Cells Contain Acidic sorption in Experimental Porcine Hepatitis C Patients Before and After Endosomal-Lysosomal Compart• Cryptosporidiosis, 104:440 Interferon Alfa Treatment, 104:1472 ments and Express Class II Major Arias IM. Cyclosporin, the Biology of the Ballet F. See Loeper J Histocompatibility Complex Deter• Bile Canaliculus, and Cholestasis, Banerjee A. Thromboxanes, Indometha- minants, 104:698 104:1558-e cin, and Experimental Colitis, Altschuler SM, Escardo J, Lynn RB, Armelao F. See Anti M 104:1891-c Miselis RR. The Central Organiza• Arranz E, Ferguson A. Intestinal Anti• Banwell JG, Howard R, Kabir I, Adrian tion of the Vagus Nerve Innervating body Pattern of Celiac Disease: Oc• TE, Diamond RH, Abramowsky C. the Colon of the Rat, 104:502 currence in Patients With Normal Small Intestinal Growth Caused by Aluffi E. See Mondardini A Jejunal Biopsy Histology, 104:1263 Feeding Red Kidney Bean Phytohe- magglutinin Lectin to Rats, 104:1669 Barrett KE. Adhesion Molecule Expression in In• KEY TO ABBREVIATIONS flammatory Bowel Disease. Com• aga—American Gastroenterological Asso• c—Correspondence ment, 104:1569-srr ciation e—Editorials An Enteric Pathogen Subverts Epithe• br—Book Reviews paps —Policy and Position Statement lial Signal Transduction Mechanisms cr—Case Reports ss—Selected Summaries for Invasion. Comment, 104:326-ss cch —Clinical Challenges srr—Special Reports and Reviews Bartula L. See Myers S ceig— Commemorative Essays in Gastroen• tmig—This Month in Gastroenterology Basavappa S, Middleton j, Mangel AW, terol ogy vodd —Viewpoints on Digestive Diseases McGill JM, Cohn JA, Fitz JG. CI" 1896 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

and K+ Transport in Human Biliary Berenson MM, Johnson TD, Markowitz Boland CR. See Lynch HT Cell Lines, 104:1796 NR, Buchi KN, Samowitz WS. Res• Boland CR, Scheiman JM, Kraus ER. Bass BL. See Benya RV toration of Sqamous Mucosa After Regulation of Canine Gastric Mucin Bass NM. Hepatobiliary Diseases, 104:1882-br Ablation of Barrett's Esophageal Ep• Synthesis and Phospholipid Secretion Bates JN. See Conklin JL ithelium, 104:1686 by Acid Secretagogues. Reply, Bauer AJ. See Stark ME Bernardi M. Hyperdynamic Circulation in 104:1889-c Bayerdörffer E, Mannes GA, Ochsenkühn Cirrhosis: Physiology or Pathophysi• Bologna E. See Angelico M T, Kopeke W, Wiebecke B, ology?, 104:1579-c Bommelaer G. See Mosnier P Paumgartner G. Increased Risk of Bernardi P. See Mondardini A Bonino F. See Botarelli P 'High-Risk' Colorectal Adenomas in Bernstein CN. See Shanahan F Borgeat A, Wilder-Smith OHG, Mentha Overweight Men, 104:137 Bernstein CN, Shanahan F. G. Subhypnotic Doses of Propofol Bayerdörffer E, Mannes GA, Richter WO, Bowel Rest and Elemental Diet in Relieve Pruritis Associated W?ith Ochsenkühn T, Wiebecke B, Kopeke Crohn's Disease. Reply, 104:1239 Liver Disease, 104:244 W, Paumgartner G. Increased Serum Purine Analogues and Ulcerative Coli• Bories P. See Gendre J-P Deoxycholic Acid Levels in Men tis. Comment, 104:325-ss Borum M, Steinberg W, Steer M, With Colorectal Adenomas, 104:145 Bernuau J. See Feray C Freedman S, White P. Chronic Pan• Bayless TM. See Mishra L Bertoni G. See Sassatelli R creatitis: A Complication of Systemic Beau P. See Ferezou J Beuers U, Nathanson MH, Boyer JL. Ef• Lupus Erythematosis, 104:613-cr Beauchamp RD. See Guo Y-S fects of Tauroursodeoxycholic Acid Bosch J. See Luca A Beaune P. See Loeper J on Cytosolic Ca2+ Signals in Isolated Botarelli P, Brunetto MR, Minutello MA, Bechi P, Amorosi A, Mazzanti R, Dei R, Rat Hepatocytes, 104:604 Calvo P, Unutmaz D, W'einer AJ, Bianchi S, Mugnai L, Masini PI Re• Beuers U, Spengler U, Paumgartner G. Choo Q-L, Shuster JR, Kuo G, flux-Related Gastric Mucosal Injury Promises, Promises: Ursodeoxycholic Bonino F, Houghton M, Abrignani Is Associated With Increased Muco• Acid for Primary Sclerosing Cholan• A. T-Lymphocyte Response to Hepa• sal Histamine Content in Humans, gitis. Reply, 104:943-ss titis C Virus in Different Clinical 104:1057 Beveridge DJ. See Fuller PJ Courses of Infection, 104:580 Beck IT. See Dinda PK Bhatti S. See Güldütuna S Boudreaux CW. See Gremse DA Bedogni G. See Sassatelli R Biancani P. See Behar J Bouvry M. See Gendre J-P Befus AD. See Hogaboam CM Bianchi S. See Bechi P Bowes KL. See Mintchev MP Bickel A, Shtamler B, Mizrahi S. Postop• Boyer JL. See Beuers U Beger HG. See Büchler M erative Feeding: Liquid Versus Solid Boyer N. See Marcellin P Behar J, Rhim BY, Thompson W, Fuel. Reply, 104:324-ss Brandt Lj. See Schoen RE Biancani P. Inositol Triphosphate Bilski J. See Konturek SJ Brandtzaeg P. See Lucidarme D Restores Impaired Human Gallblad• Biolo G. See Tcssari P Breanndan Moore S. Sec Czaja AJ der Motility Associated With Choles• Birch Mj. See Kalabakas AA Brechot C. See Feray C terol Stones, 104:563 Bishop AE. See Walters JRF Brehm R. See Swoboda K Belai A. See Soediono P Bismuth II. See Feray C Bremondy A. See Gendre J-P Beiaich S. See Marcellin P Bissonnette EY. See Hogaboam CM Brewer GJ. Zinc in the Treatment of Belghiti J. See Loeper J Bjarnason I, Hayllar J, MacPherson AJ, Wilson's Disease: How It Works. Bell C. See Li Z Russell AS. Side Effects of Nonste• Reply, 104:l568-srr Bell SM, Scott N, Cross D, Sagar P, Lewis roidal Anti-inflammatory Drugs on Brissot P. See Deugnier YM FA, Blair GE, Taylor GR, Dixon the Small and Large Intestine in Hu• Broide E, Scapa E, Peer A, Witz E, MF, Quirke P. Prognostic Value of mans, 104:1832-srr Abramowich D, Eshchar j. Buerger's p53 Overexpression and c-Ki-ras Blackstone MO. Are Early Electron-Mi• Disease Presenting as Acute Small Gene Mutations in Colorectal croscopic Acinar Cell Derangements Bowel Ischemia, I04:l192-cr Cancer, 104:57 in Opossum Pancreatitis Critical for Brotea G. Absence of False Elevations Bendtsen F. See Henriksen JH Coagulative Necrosis at 7 Days?, With Kodak Ektachem Lipase, BenhamouJ-P. See Marcellin P 104:1236-c 104:1580-c Benhattar J, Losi L, Chaubert P, Givel Blair GE. See Bell SM Brunetto MR. See Botarelli P J-C, Costa J. Prognostic Significance Blanco MC. See FoxJG Brunner G. See Lamberts R of K-ras Mutations in Colorectal Blennerhassett P. See Main C Brydon G. See Choudari CP Carcinoma, 104:1044 Bleyzer I. See Genta RM Buchan AMj, Meloche RM, Kwok YN, Benner KG. Guide to Liver Transplantation, Boda MI. See Khuroo MS Kofod H. Effect of Cholecystokinin 104:1233-br Bodenheimer HC Jr. See Lefkowitch JH and Secretin on Somatostatin Release Benya RV, Duncan MD, Mishra L, Bass Boeckxstaens GE, Pelckmans PA, Herman From Cultured Antral Cells, 104:1414 BL, Voyles NR, Korman LY. Extra• AG, Van Maercke YM. Involvement Buchi KN. See Berenson MM cellular Matrix Composition Influ• of Nitric Oxide in the Inhibitory Büchler M, Malfertheiner P, Uhl W, ences Insulinlike Growth Factor I Innervation of the Human Isolated Schölmerich J, Stöckmann F, Adler Receptor Expression in Rat I EC-18 Colon, 104:690 G, Gaus W, Rolle K, Beger HG, Cells, 104:1705 Böhme M. See Kadmon M German Pancreatitis Study Group. June 1993 AUTHOR INDEX 1897

Gabexate Mesilate in Human Acute Chan T-M, Lok ASF, Cheng IKP, Chan Ciain JE. Management of Gastrointestinal Dis• Pancreatitis, 104:1165 RT. A Prospective Study of Hepatitis eases (volumes 1 and 2), 104:1576-br Bueno L C Virus Infection Among Renal Cläria J. See Asbert M See Fargeas M-J Transplant Recipients, 104:862 Clayton PT. See Portmann B See Morteau O Chandler K. See Ohya T Cohn JA. See Basavappa S Bukhave K. See Yao B Chang W-Y. See Chuang W-L Coll S. See Andreu M BurakofF R. See Percy WH Chaubert P. See Benhattar J Collins SM Burch RM. See Noronha-Blob L Chaussade S. See Lucidarme D See Grossi L Burchert M. See Lambrecht N Cheinquer H. See Liang TJ See Main C Buret A. See Li Z Chen A. See Sperber K See Vermillion DL Burmer GC. The Timing of p53 Inactiva- Chen BW. See Hui WM Collman PI, Tremblay L, Diamant NE. tion in Chronic Ulcerative Colitis. Chen JDZ, Mittal RK. Nausea and Vom• The Central Vagal Efferent Supply Reply, 104:1890-c iting of Pregnancy and Cutaneous to the Esophagus and Lower Esoph• Burn stock G. See Soediono P Electrogastrogram. Comment, ageal Sphincter of the Cat, 104:1430 Burt RW, Groden J. The Genetic and 104:1570-srr Colman J. See Wong F Molecular Diagnosis of Adenomatous Cheng IKP. See Chan T-M Colombato LA. See Albillos A Polyposis Coli, 104:1211-e Chevalier E Colombel J-F Burton MB. See Percy WH See Pascaud XB See Adenis A Busch N. See Ohya T See Riviere PJM See Gendre J-P Butler-Simon N. See Sokol R Chin BC. See Hogaboam CM See Lucidarme D Buzzelli G. See Gentilini P Choi PM. Predominance of Rectosigmoid See Van Kruiningen HJ By 1 B, Roucloux I, Crusiaux A, DuPont E, Neoplasia in Ulcerative Colitis and Cominelli F. See Youngman KR Deviere J. Tumor Necrosis Factor a Its Implication on Cancer Surveil• Compton CC. See Ryan CM and Interleukin 6 Plasma Levels in lance, 104:666-c Conklin JL. See Murray J Infected Cirrhotic Patients, 104:1492 Cho CH. See Hui WM Conklin JL, Du C, Murray JA, Bates JN. Byles NI. See Meddings JB Choo Q-L. See Botarelli P Characterization and Mediation of Choudari CP, O'Mahony S, Brydon G, Inhibitory Junction Potentials From Calam J. See Moss SF Mwantembe O, Ferguson A. Gut Opossum Lower Esophageal Lavage Fluid Protein Concentrations: Calvo P. See Botarelli P Sphincter, 104:1439 Camby P. See David E Objective Measures of Disease Activ• Conn HO. Hepatic Encephalopathy, Cameron AJ. ity in Inflammatory Bowel Disease, 104:1576-br Evolution of Barrett's Esophagus: The 104:1064 Conner C. See Sokol R Jury Is Still Out. Reply, 104:1236-c Chovet M. See Pascaud XB Connors PJ, Friedman LS. Pancreas Divi• Molecular Events in Barrett's Metapla• Chowdhury P. See Doi R sum: To Stent or Not to Stent. Com• sia. Reply, 104:1235-c Christensen NJ. See HenriksenJH ment, 104:1227-ss See Pera M Christi SU, Gibson GR, Murgatroyd PR, Conrad ME, Umbreit JN, Moore EG. Rat Cameron RG. See Matsui j Scheppach W, Cummings JH. Im• Duodenal Iron-Binding Protein Campbell KL. More Problems With paired Hydrogen Metabolism in Mobilferrin Is a Homologue of Calre- Aspirin: It May Cause Appendicitis. Pneumatosis Cystoides Intestinalis, ticulin, 104:1700 Reply, 104:1572-srr 104:392 Cooper BT. See Igbal TH Campion j-P. See Deugnier YM Christof! FL, WoodJD. Presynaptic Inhi• Cornaggia M Capella C. See Rindi G bition by Adenosine Receptors on See Maiuri L Capocaccia L. See Angelico M Guinea Pig Small Intestinal Myen• See Rindi G Cappelli G. See Gentium P teric Neurons, 104:1420 Correa P. See Lechago J Carey W. See Lefkowitch JH Chu S-HW, Walker WA. Bacterial Toxin Cortot A Carli L. See Angelico M Interaction With the Developing In• Carpenter HA testine, 104:916-srr See Adenis A See Ambroze WLJr Chuang W-L, Omata M, Ehata T, See Van Kruiningen HJ See Czaja AJ Yokosuka O, Ito Y, Imazeki F, Lu Costa J. See Benhattar J See Pera M S-N, Chang W-Y, Ohto M. Precore Cragoe EJ Jr. See Tobey NA See Wolfsen HC Mutations and Core Clustering Mu• Crantock L. See Deugnier YM Carter K. See Paimela H tations in Chronic Hepatitis B Virus Cresteil D. See Yamamoto AM Cartun RW. See Van Kruiningen HJ Infection, 104:263 Creutzfeldt W. See Lamberts R Castagliuolo I. See Pothoulakis C Chung RT, Schapiro RH, Warshaw AL. Crickx B. See Marcellin P Cate TR. See Genta RM Intraluminal Pancreatic Candidiasis Crombie DL. See Lillienau J Cavalieri RJ. See Lynch HT Presenting as Recurrent Pancreatitis, Cross D. See Bell SM Chambon P. See Wright NA 104:1532-cr Crusiaux A. See By! B Champarnaud G. See Ferezou J Cieszkowski M. See Konturek SJ Cullere X. See Perez-Tomas R Chan C-Y. See Lee S-D Cirera I. See Luca A Cummings JH. See Christi SU Chan RT. See Chan T-M Ciucchiu S. See Fiorucci S Cuthbertson AM. See St. John DJB 1898 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

Czaja AJ, Carpenter HA, Santrach PJ, and Chronic Pancreatitis, 104:1255- Normal Manometry Results in Group I Breanndan Moore S, Homberger HA. ceig Sphincter of Oddi Dyskinesia Pa• The Nature and Prognosis of Severe Dinda PK, Holitzner CA, Morris GP, tients. Reply, 104:1244-c Cryptogenic Chronic Active Hepati• Beck IT. Ethanol-Induced Jejunal Endo O. See Kiba T tis, 104:1755 Microvascular and Morphological Endoh K, Kao J, Domek MJ, Leung FW. Injury in Relation to Histamine Re• Mechanism of Gastric Hyperemia Dabelsteen E. See Maiuri L lease in Rabbits, 104:361 Induced by Intragastric Hypertonic Dajani EZ. CO-3 Fatty Acids and Bowel Dirschedl P. See Lindemann F Saline In Rats, 104:114 Cancer, 104:1239-c Dixon MF. See Bell SM Ergun GA. See Kahrilas PJ Daly JM. Immunonutrition? Reply, Djordjevic D, Popovic OS. Intestinal In• Ericsson CD. See DuPont HL 104:938-ss volvement in Sarcoidosis. Reply, Erlinger S. See Marcellin P Dar MY. See Khuroo MS l04:947-c Esber EJ. See Imperiale TF Dash S. See Balart LA Doi R, Inoue K, Chowdhury P, Kaji Fl, Escardo J. See Altschuler SM DaSilva MM. See Wool rich AJ Rayford PL. Structural and Func• Eshchar J. See Broide E David E, Rahier J, Pucci A, Camby P, tional Changes of Exocrine Pancreas Eyssen H. See Ectors N Scevens M, Salizzoni M, Otte JB, Induced by FK506 in Rats, 104:1153 Galmarini D, Marinucci G, Domek MJ. See Endoh K Fabiano A. See David E Ottobrelli A, Marzano A, Smedile A, Facchini F. See Kahrilas PJ Donovan V. See Percy W7H Fabiano A, Mollo F, Verme G, Dowling RH. See Ulshen MH Facer P. See Walters JRF Rizzetto M. Recurrence of Hepatitis Dozois RR. See Ambroze WL jr Falkmer UG. See Van Solinge WW D (Delta) in Liver Transplants: His- Drossman DA, Sandler RS, Sartor RB. Fargeas M-J, Fioramonti J, Bueno L. topathological Aspects, 104:1122 Our New President—Don W. Central Action of Interleukin iß on Davis GL. See Lefkowitch JH Powell, M.D., 104:1249-aga Intestinal Motility in Rats: Mediation Dawra R. See Lerch MM by Two Mechanisms, 104:377 Druml W. See Swroboda K Deacon MC. See St. John DJB Faris RA. See Yang L Du C Debennin J-P. See Lucidarme D See Conklin JL Fayer JC. See Stahl GE de Bolos C. See Gambus G See Murray J Fehr HF. See Schmassmann A Dei R. See Bechi P Dubner H, Fromm H. Ursodeoxycholic Feit D. See Lefkowitch JH De Laet MH. See Vanderwinden j-M Acid Treatment of Intrahepatic Cho• Feldmann G. See Loeper J De Leede LGJ. D:See Hespe W lestasis of Pregnancy: Observations Fenoglio-Preiser C. Pathology of the Gastroin• De Medina M. See Liang TJ on Efficacy and Safety, Comment, testinal Tract, 104:663-br Derfler K. See Swoboda K 104:660-ss Feray C, Gigou M, Samuel D, Reyes G, Descamps V. See Marcellin P Dudley F. See Wong F Bernuau J, Reynes M, Bismuth II, Descatoire V. See Loeper J Brechot C. Hepatitis C Virus RNA Duncan A. See Roediger WEW Descos L. See Gendre J-P and Hepatitis B Virus DNA in Serum Duncan MD. See Benya RV Descroix-Vagne M. Regulation of Canine and Liver of Patients With Fulmi• DuPont E. See Byl B Gastric Mucin Synthesis and Phos• nant Hepatitis, 104:549 DuPont HL, Ericsson CD, Mathewson JJ, pholipid Secretion by Acid Secreta- Marani S, Knellwolf-Cousin A-L, Ferezou J, Beau P, Parquet M, gogues, 104:1888-c Martinez-Sandoval FG. Zaldaride Champarnaud G, Lutton C, Deugnier YM, Guyader D, Crantock L, Maleate, an Intestinal Calmodulin Matuchansky C. Cholesterol and Bile Lopez J-M, Turlin B, Yaouanq j, Inhibitor, in the Therapy of Trav• Acid Biodynamics After Total Small Jouanolle H, Campion J-P, Launois elers' Diarrhea, 104:709 Bowel Resection and Bile Diversion B, HallidayJW, Powell LW, Brissot in Humans, 104:1786 P. Primary Liver Cancer in Genetic Eaton RA. See Tarazi EM Ferguson A Hemochromatosis: A Clinical, Eberer AJ, Santa Ana CA, Porter J, See Arranz E Pathological, and Pathogenetic Study Fordtran JS. Effect of Psyllium, Cal• See Choudari CP of 54 Cases, 104:228 cium Polycarbophil, and Wheat Bran Fernandez CM, Prieto J, Zozaya JM, DeviereJ. See By! B on Secretory Diarrhea Induced by QuirogaJ, Guitian R. Arteriovenous Devred M. See Van Kruiningen HJ Phenolphthalein, 104:1007 Shunting, Hemodynamic Changes, Dewhirst FE. See FoxJG Ebringer H. See Swoboda K and Renal Sodium Retention in Liver Diamant NE Ectors N, Henneresse P-E, Geboes K, Cirrhosis, 104:1139 See Coll man PI Eyssen H, Janssens J, Vantrappen G. Feu F. See Luca A See Salapatek AMF Animal Models for Helicobacter pylori, Findor A. See Liang TJ Diamond RH. See Banwell JG I04:1886-c Fiocca R. See Maiuri L Diaz C. See Perez-Tomas R Egami K. See Ohya T Fiocchi C. Di Bisceglie AM Egea G. See Gambus G Cytokines and Animal Models: A Com• See Bacon BR Ehata T. See Chuang W-L bined Path to Inflammatory Bowel See Hoof nagle JH Elia G. See Wright NA Disease Pathogenesis, 104:1202-e Dienstag JL. See Lefkowitch JH Elta GH. See Matsuura T DiMagno EP. A Short, Eclectic History of Appendectomy —Will the Laparoscope See Youngman KR Exocrine Pancreatic Insufficiency Reign? Comment, 104:936-ss Fioramonti J. See Fargeas M-J June 1993 AUTHOR INDEX 1899

Fiorucci S, Morelli A. Motilin and Eryth• Gao N. See Pothoulakis C Gines P romycin Stimulate Pepsinogen Secre• Garcia-Pagän JC. See Luca A See Asbert M tion by Chief Cells Isolated From Gastroenterology Board of the American See Badalamenti S Guinea Pig Stomach, 104:1030 Board of Internal Medicine. Recerti- Gineston J-L. See Gendre J-P Fiorucci S, Santucci L, Ciucchiü S, Morelli fication in Gastroenterology, Gitnick GL. See Singleton JW A. Alkaline Esophageal Reflux—A 104:1220-paps Givel J-C. See Benhattar J Misnomer. Reply, l04:948-c Gaus W. See Büch 1 er M Glamour T. See McCullough AJ Fitz JG. See Basavappa S Gauthier T. See Minuk GY Goddard PJ. See Paimela H Fitzgerald JE. See HyamsJS Gearty JC. See Igbal TH Goldstein JL, Fogelson BG, Snow JC, Flemens EE. See Stone MJ Gebhard RL. 10 g of Fat per Day May- Schmidt LN, Mozwecz H, Layden TJ. Flemström G. See Knutson L Keep Gallstones Away. Reply, Rabbit Esophageal Cells Possess K+ Flemström G, Säfsten B, Jedstedt G. 104:1881-ss Channels: Effect of Hyposmotic Stress on Channel Activity, 104:417 Stimulation of Mucosal Alkaline Se• Geboes K. See Ectors N cretion in Rat Duodenum by Dopa• Gendre J-P, Mary J-Y, Florent C, Goldstein R. See Scully LJ Goldstein RM. See Stone MJ mine and Dopaminergic Compounds, Modigliani R, Colombel J-F, Soule Gondo K, Ueno T, Sakamoto M, Sakisaka 104:825 J-C, Galmiche J-P, Lerebours E, S, Sata M, Tanikawa K. The Endoth• Florent C. See Gendre J-P Descos L, Viteau J-M, Rene E, elial Binding Site in Rat Liver Tis• Fogelson BG. See Goldstein JL Metman E-H, Bories P, Bremondy sue: Light- and Electron-Microscopic Fordtran JS. See Eberer AJ A, Bouvry M, Lamouliatte H, Autoradiographic Studies, 104:1745 Foschi M. See Gentilini P Gineston J-L, Groupe d'Etudes Gores GJ, Steers JL. Progress in Ortho• Fox JG, Blanco MC, Yan L, Shames B, Therapeutiques des Affections In- topic Liver Transplantation for He• Polidoro D, Dewhirst FE, Paster BJ. flammatoires Digestives (GET AID). patocellular Carcinoma, 104:317-e Role of Gastric pH in Isolation of Oral Mesalamine (Pentasa) as Main• Gorgas K. See Kadmon M Helicobacter mustelae From the Feces of tenance Treatment in Crohn's Dis• Goto M. See Yamaguchi Y Ferrets, 104:86 ease: A Multicenter Placebo-Con• Graham DY, Lew GM, Lechago J. Antral Franci C. See Gambias G trolled Study, 104:435 G-Cell and D-Cell Numbers in Heli• Freedman S. See Borum M Genta RM, Bleyzer I, Cate TR, Tandon cobacter pylori Infection: Effect of H. Friedman LS. AK, Yoffe B. In Situ Hybridization pylori eradication, 104:1655 See Connors PJ and Immunohistochemical Analysis Graham JR. Omeprazole and Gastric Polyp• Zinc in the Treatment of Wilson's Dis• of Cytomegalovirus-Associated Ileal osis in Humans, 104:1584-c ease: How It Works. Comment, Perforation, 104:1822-cr Granger DN. See Asako H I04:1566-srr Gentile S. See Angelico M Greathead P. See Pories SE Friis-Hansen L. See Van Solinge WW Gentilini P, Romanelli RG, La Villa G, Greenberg RB. Hospital Credentialing Fromm H Maggiore Q, Pesciullesi E, Cappel Ii Standards for Physicians Who Per• See Dubner H G, Raggi VC, Foschi M, Marra F, form Endoscopies, 104:1563-paps See Levenson DE Pinzani M, Buzzelli G, Laffi G. Ef• Greenwald BD. See Yin J Fujita K. See Hagiwara A fects of Low-Dose Captopril on Gremse DA, Boudreaux CW, Manci EA. Fujiwara K. See Arai M Renal Hemodynamics and Function Collagenous Colitis in Children, Fuller CR. See Ulshen MH in Patients With Cirrhosis of the 104:906-cr Fuller PJ, Beveridge DJ, Taylor RG. Ileal Liver, 104:588 Gresky S. See Ohya T Proglucagon Gene Expression in the Gerber MA. See Balart LA Grisham MB. See Yamada T Rat: Characterization in Intestinal Gerbes AL. See Henriksen JH Groden J. See Burt RW Adaptation Using In Situ Hybridiza• Gerhardt W See Nordin G Gross IB Jr. Promises, Promises: Urso• tion, 104:459 German Pancreatitis Study Group. See deoxycholic Acid for Primary Scle• Funakoshi A. See Miyasaka K Büchler M rosing Cholangitis. Comment, FungJ. See Starzl TE Geypens BJ. See Ghoos YF 104:942-ss Furness JB. See Padbury RTA Grossi L, McHugh K, Collins SM. On the Fusamoto H Ghoos YF, Maes BD, Geypens BJ, Mys G, Specificity of Altered Muscle Func• See Hagiwara H Hiele Ml, Rutgeerts PJ, Vantrappen tion in Experimental Colitis in Rats, See Tsujii M G. Measurement of Gastric Emptying Rate of Solids by Means of a Carbon- 104:1049 Gallen M. See Andreu M Labeled Octanoic Acid Breath Test, Groszmann RJ Galmarini D. See David E 104:1640 See Albillos A Galmiche J-P. See Gendre J-P Gianella RA. Enteric Infections: 50 Years See Sieber CC Gambüs G, de Bolos C, Andreu D, Franci of Progress, 104:1589-ceig Groupe d'Etudes Therapeutiques des Af• C, Egea G, Real FX. Detection of Gibas A. See Lefkowitch JH fections Inflammatoires Digestives the MUC2 Apomucin Tandem Re• Gibson GR. See Christi SU (GET AID). See Gendre J-P peat With a Mouse Monoclonal An• Gigou M. See Feray C Guengerich FP. See Loeper J tibody, 104:93 Gilbert RJ. The Esophagus, 104:1232-br Guillevin L. See Marcellin P Gantz D. See Afdhal NH Gines A. See Asbert M Guitian R. See Fernandez CM 1900 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

Güldütuna S, Zimmer G, Imbof M, Bhatti See Ohtawa M Holzbach RT S, You T, Leuschner U. Molecular See Tsujii M See A bei M Aspects of Membrane Stabilization Hayllar J. See Bjarnason I See Ohya T by Ursodeoxycholate, 104:1736 Hedrich D. See Karlstadt RG Homberg JC. See Yamamoto AM Guo Y-S, Beauchamp RD, Jin G-F, Heiss FW. See Asbun HJ Homberger HA. See Czaja AJ Townsend CM Jr, Thompson JC. In• Heng Y. See Krishnamurthy S Hontanosas M. See Yin J sulinlike Growth Factor-Binding Henneresse P-E. See Ectors N HoofnagleJH, Di Bisceglie AM, Protein Modulates the Growth Re• Henriksen JH, Bendtsen F, Gerbes AL, Waggoner JG, Park Y. Interferon sponse to Insulinlike Growth Factor Christensen NJ, Ring-Larsen H, Alpha for Patients With Clinically 1 by Human Gastric Cancer Cells, Sorensen TIA. Central Blood Volume Apparent Cirrhosis Due to Chronic 104:1595 in Cirrhosis. Reply, 104:1879-ss Hepatitis B, 104:1116 Gurbindo C, Russo P, Sabbah S, Lohoues Henry D, Robertson j. Nonsteroidal Hoogkamp-Korstanje JAA. See Van M-J, Seidman E. Interleukin-2 Ac• Anti-inflammatory Drugs and Peptic Kruiningen HJ tivity of Colonic Lamina Propria Ulcer Hospitalization Rates in New Horina JH, Petritsch W;, Schmid CR, Mononuclear Cells in a Rat Model of South Wales, 104:1083 Reicht G, Wenzl H, Silly H, Krejs GJ. Experimental Colitis, 104:964 Hepatitis Interventional Therapy Group. Treatment of Anemia in Inflamma• Guyader D. See Deugnier YM See Lefkowitch JH tory Bowel Disease With Recombi• Herbsman N. See Hornsby-Lewis L nant Human Erythropoietin, Hagey LR. See LillienauJ Herfarth C. See Kadmon M 104:1828-cr Hagiwara A, Takahashi T, Kojima O, Herman AG. See Boeckxstaens GE Hornsby-Lewis L, Herbsman N. Predict• Kitamura K, Sakakura C, Hermon-Taylor J. Causation of Crohn's ing Recurrence in Colorectal Cancer Shoubayashi S, Osaki K, Iwamoto A, Disease: The Impact of Clusters, Patients. Comment, 104:1225-ss Lee M, Fujita K. Endoscopic Local 104:643-e Hoschl R. See Scott AM Injection of a New Drug-Delivery Hespe W, Kamsteeg FI, Harmsen AR, Hall Houghton M. See Botarelli P Format of Peplomycin for Superficial DWR, De Leede LGJ. The Mecha• Houssin D. See Loeper J Esophageal Cancer: A Pilot Study, nism of Bismuth Absorption, Howard R. See Banwell JG 104:1037 104:1242-c Hsu JJ, O'Connor MK, Kang YW, Kim CFL Nonspecific Motor Disorder of Hagiwara H, Hay ash i N, Mita E, Takehara Hesslewood SR. See Kmiot WA the Esophagus: A Real Disorder or a T, Kasahara A, Fusamoto H, Kamada Heubi JE. See Sokol R Manometric Curiosity?, 104:1281 T. Quantitative Analysis of Hepatitis Heuman DM. Hepatoprotective Properties Hsu P. See Wong F C Virus RNA in Serum During In• in Ursodeoxycholic Acid, 104:1865-e Hu S. See Stern RM terferon Alfa Therapy, 104:877 Hey man MB. See Sokol R Huang Y. See Yin J Hakkak R, Ronis MJJ, Badger TM. Effects Hiele MI. See Ghoos YF Hui WM, Chen BW, Kung AWC, Cho of Enteral Nutrition and tithanol on Higenbottam TW. See Portmann B CH, Luk CT, Lam SK. Effect of Cytochrome P450 Distribution in Hiraishi H, Terano A, Razandi M, Epidermal Growth Factor on Gastric Small Intestine of Male Rats, Sugimoto T, Harada T, Ivey KJ. Role Blood Flow in Rats: Possible Role in 104:1611 of Iron and Superoxide in Mediating Mucosal Protection, 104:1605 Hall DWR. See Hespe W 1242 Hydrogen Peroxide Injury to Cul• HuizingaJD. See Vermillion DL Hällgren R. See Adenis A tured Rat Gastric Cells, 104:780 Husberg BS. See Stone MJ Halliday JW. See Deugnier YM Hirschowitz BL Development and Appli• Hyams JS. See Treem WR Hamasaki K. See Tsutsumi T cation of Endoscopy, 104:337-ceig Hyams JS, Fitzgerald JE, Treem WR, Hanauer SB. See Singleton JW Hixson DC. See Yang L Wyzga N, Kreutzer DL. Relationship Harada T. See Hiraishi H Hofmann AF of Functional and Antigenic Inter- Harding LK. See Kmiot WA See Lillienau J leukin 6 to Disease Activity in In• Harmsen AR. See Hespe W See Schmassmann A flammatory Bowel Disease, 104:1285 Harpaz N. See Yin J Hogaboam CM, Bissonnette EY, Chin BC, Harris M. See Mishra L Befus AD, Wallace JL. Prostaglan• Harter JG. See Tarazi EM dins Inhibit Inflammatory Mediator lannaccone ST. See Sokol R Harty RF. See Ren j Release From Rat Mast Cells, 104:122 Igbal TH, Gearty JC, Cooper BT. I mm uno• Harvey PRC, Strasberg SM. Will the Real Hogan DL. See Yao B proliferative Small Intestinal Disease Cholesterol-Nucleating and -Antinu- Hogan WJ. or Celiac Disease, 104:1887-c cleating Proteins Please Stand Up?, Credentialing, 104:1563-paps Igimi H. See Ohya T 104:646-e Gastroenterology Board Recertification: Ilan Y, Nagler A, Adler R, Tur-Kaspa R, Hasegawa H. See Matsushita K A Mandate for Continuing Scholar• Slavin S, Shouval D. Ablation of Hasler WL, Soudah HC, Owyang C. A ship, 104:1221-paps Persistent Hepatitis B by Bone Somatostatin Analogue Inhibits Af• Holitzner CA. See Dinda PK Marrow Transplantation From a ferent Pathways Mediating Percep• Hollander D. Permeability in Crohn's Hepatitis B-Immune Donor, tion of Rectal Distension, 104:1390 Disease: Altered Barrier Functions in 104:1818-cr Hayashi N Healthy Relatives?, 104:1848-e Ilstrup DM. See Ambroze WLJr See Hagiwara H Holtermüller K-H. See Protzer U Imazeki F. See Chuang W-L June 1993 AUTHOR INDEX 1901

Imbof M. See Güldütuna S Action: Volume Accomodation and Kingma YJ. See Mintchev MP Imperiale TF, Esber EJ. Preventing Infec• Bolus Propulsion, 104:152 Kirsner JB. The Specialization of Gastro• tion in Cirrhotics With Gastrointes• Kairaluoma MI. See Juvonen T enterology in America, 104:6-ceig tinal Hemorrhage, 104:1238-c Kaji H. See Doi R Kitamura K. See Hagiwara A Inchiostro S. See Tessari P Kalabakas AA, Porter AJ, Mule L, Birch Kitani K. See Miyasaka K Inoue K. See Doi R MJ, Pollock DJ, Swain CP. Design Kiyobara T, Okuno M, Nakanishi T, Inoue S. See Kiba T of a Microwave System for Endos• Shinomura Y, Matsuzawa Y. Effect Isenberg JI. See Yao B copy: An Experimental Study of En• of Endothelin 1 on Ion Transport in Ishak KG. See Tarazi EM ergy, Tissue Contact, and Hemostatic Isolated Rat Colon, 104:1328 Ishikawa T. See Kadmon M Efficacy, 104:680 Klein GL. Aluminum and Hepatobiliary Ito S. See Paimela H Kalley-Taylor B. See Myers S Complications of Triphosphopyri- Ito T. See Tsujii M Kamada T dine Nucleotide, 104:1583-c Ito Y. See Chuang W-L See Hagiwara H Klein JS Itoh Z. See Ohtawa M See Tsujii M See Matsuura T Itzkowitz S. See Sperber K Kamsteeg H. See Hespe W See Youngman KR Key KJ. See Hiraishi H Kang YW. See Hsu JJ Klintmalm GBG. See Stone MJ Iwamoto A. See Hagiwara A Kangro HO. See Van Kruiningen HJ Klünemann C. See Kadmon M Kao J. See Endoh K Kmiot WA, Hesslewood SR, Smith N, Jacobson IM. See Lefkowitch JH Kao Y-C J, Lichtenberger LM. Effect of Thompson H, Harding LK, Keighley Janin A. See Adenis A 16,16-Dimethyl Prostaglandin E2 on MRB. Evaluation of the Inflamma• Jankowski J. Molecular Events in Barrett's Lipidic Organelles of Rat Gastric tory Infiltrate in Pouchitis With Metaplasia, 104:1235-c Surface Mucosal Cells, 104:103 mIn-Labeled Granulocytes, 104:981 JanssensJ. See Ectors N Kapaniris O. See Roediger WEW Kmu K-M-U. See Zheng B-Y Javaid G. See Khuroo MS Kaplan MM. New Strategies Needed for Knellwolf-Cousin A-L. See DuPont HL Jayanthi V. See Victor S Treatment of Primary Biliary Cir• Knutson L, Knutson TW, Flemström G. Jed steel t G. See Flemström G rhosis?, 104:651-e Endogenous Dopamine and Duo• Jeejeebhoy KN. See Matsui J Karlstadt RG, Hedrich D, Palmer R. Up• denal Bicarbonate Secretion in Hu• jeffers L. See Liang TJ per Gastrointestinal Bleeding in the mans, 104:1409 JefTery R. See Wright NA Critically 111, 104:1885-c Knutson TW. See Knutson L Jimenez W. See Asbert M Kasahara A. See Hagiwara H Koch KL. See Stern RM Jin G. See Sorrell WT Kasuga M. See Matsushita K Koch TK. See Sokol R Jin G-F. See Guo Y-S Kato T, Owen RL. lectin Binding to Giyco- Koff RS. A Redoubtable Obstacle to a Johnson LR. See Wang j-Y conjugates of the Human Gastric Fundus, Hepatitis C Vaccine. Comment, Johnson TD. Sec Berenson MM 104:1883-br Johnson TJ. See Sorrell WT 104:1228-ss Kauppila T. See Tanila H Jones MP. See Scott AM Kofod H. See Buchan AMJ Kawano S. See Tsujii M Joshi MA. See Pothoulakis C Koide M. See Matsushita K Kawczak P. See Abei M Jouanolle H. See Deugnier YM Kojima O. See Hagiwara A Junien J-L Keighley MRB. See Kmiot WA Konturek PK. See Konturek SJ See Pascaud XB KellowJEl. See Scott AM Konturek SJ, Bilski J, Konturek PK, See Riviere PJM Kelly CP. See Pothoulakis C Cieszkowski M, Pawlik W. Role of Juvonen T, Kervinen K, Kairaluoma MI, Keppler D. See Kadmon M Endogenous Nitric Oxide in the Lajunen LFIJ, Kesäniemi YA. Gall• Kervinen K. See Juvonen T Control of Canine Pancreatic Secre• stone Cholesterol Content Is Related Kesäniemi YA. See Juvonen T tion and Blood Flow, 104:896 to Apolipoprotein E Polymorphism, Khakee R. See Paimela H Koopmans M. See Van Kruiningen HJ 104:1806 Khalbuss WE. See Tobey NA Kopeke W. See Bayerdörffer E Khan BA. See Khuroo MS Kopin AS. The Gastrin (or Is It CCK-B?) Kabir I. See Banwell JG Khuroo MS, Dar MY, Yattoo GN, Zargar Receptor on the Parietal Cell is Kadmon M, Klünemann C, Böhme M, SA, Javaid G, Khan BA, Boda ML Cloned. Reply, 104:1878-ss Ishikawa T, Gorgas K, Otto G, Percutaneous Drainage Versus Al• Koppensteiner R. See Swoboda K Herfarth C, Keppler D. Inhibition bendazole Therapy in Hepatic Hyda- Korelitz BI. See Woolrich AJ by Cyclosporin A of Adenosine Tri- tidosis: A Prospective, Randomized Koretz RL. phosphate-Dependent Transport Study, 104:1452 Immunonutrition? Comment, 104:937- From the Hepatocyte Into Bile, Kiba T, Tanaka K, Endo O, Inoue S. ss 104:1507 Ventromedial Hypothalamic Lesions Postoperative Feeding: Liquid Versus Kage M, Okuda K. Aetiology of Mem• Increase Gastrointestinal DNA Syn• Solid Fuel. Comment, l04:324-ss branous Obstruction of Inferior Vena thesis Through Vagus Nerve in Rats, Korman LY. See Benya RV Cava. Reply, 104:1582-c 104:475 Koss MA. See Yao B Kahrilas PJ, Lin S, Logemann JA, Ergun Kido Y. See Matsushita K Kraus ER. See Boland CR G A, Facchini F. Deglutitive Tongue Kim CH. See Hsu JJ Krawitt EL. See Singleton JW 1902 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

Krejs Gj Lebenthal E. See Zheng B-Y Levy J. See Sokol R See HorinaJH Lecce J. See Argenzio RA Lew GM. See Graham DY See Wildling R LechagoJ. See Graham DY Lewandrowski K. See Ryan CM Kreutzer DL. See Hyams JS Lechago J, Correa P. Prolonged Achlor- Lewis FA. See Bell SM Krevsky B. Noninvasive Sphincter of hydria and Gastric Neoplasia: Is Li Z, Bell C, Buret A, Robins-Browne R, Oddi Testing: What's the Score? There a Causal Relationship?, Stiel D, O'Loughlin E. The Effect Comment, 104:655-ss 104:1554-e of Enterohemorrhagic Escherichia coli Krishnamurthy S, Heng Y, Schuffler MD. Lecomte-Houcke M. See Van Kruiningen 0157:H7 on Intestinal Structure and Chronic Intestinal Pseudo-obstruc• HJ Solute Transport in Rabbits, 104:467 tion in Infants and Children Caused Lederer A. See Wildling R Liang TJ, Jeffers L, Reddy RK, Silva MO, by Diverse Abnormalities of the Lee F-Y. See Albillos A Cheinquer H, Findor A, De Medina Myenteric Plexus, 104:1398 Lee M. See Hagiwara A M, Yarbough PO, Reyes GR, Schiff Kung AWC. See Hui WM Lee S-D, Lo K-J, Chan C-Y, Yu M-Y, ER. Fulminant or Subfulminant Kuo G. See Botarelli P Wang Y-J, Safary A. Immunogenicity Non-A, Non-B Viral Hepatitis: The Kuo GC. See Matsui J of Inactivated Hepatitis A Vaccine Role of Hepatitis C and E Viruses, Kupper LL. See Sandler RS in Children, 104:1129 104:556 Kurian R. See Matsui J Lee WM. The Silent Epidemic of Hepati• Lichtenberger LM. See Kao Y-C J Kwok YN. See Buchan AMJ tis C, Comment, 104:661-ss Lillienau J. See Schmassmann A Lefkowitch JH, Schiff ER, Davis GL, Lillienau J, Crombie DL, Munoz J, Laffi G. See Gentilini P Perrillo RP, Lindsay K, Bodenheimer Longmire-Cook SJ, Hagey LR, Lajunen LHJ. See Juvonen T HC Jr, Balart LA, Ortego TJ, Payne Hofmann AF. Negative Feedback Lam SK. See Hui WM j, Dienstag JL, Gibas A, Jacobson IM, Regulation of the Ileal Bile Acid Lamberts R, Creutzfeldt W;, Strüber HG, Tamburro CH, Carey W, O'Brien C, Transport System in Rodents, 104:38 Brunner G, Solcia E. Long-Term Sampliner R, Van Thiel DH, Feit D, Lin S. See Kahrilas PJ Omeprazole Therapy in Peptic Ulcer Albrecht J, Meschievitz C, Sanghvi Lindbom L. See Raud J Disease: Gastrin, Endocrine Cell B, Vaughan RD, Flepatitis Interven• Lindemann F, Schlimok G, Dirschedl P, Growth, and Gastritis, 104:1356 tional Therapy Group. Pathological Witte j, Riethmüller G. Predicting Lambrecht N, Burchert M, Respondek M, Diagnosis of Chronic Hepatitis C: A Recurrence in Colorectal Cancer Pa• Müller K-M, Peskar BM. Role of Multicenter Comparative Study With tients. Reply, 104:1226-ss Calcitonin Gene-Related Peptide and Chronic Hepatitis B, 104:595 Lindsay K. See Lefkowitch JH Nitric Oxide in the Gastroprotective Le Gallou B. See Riviere PJM Link AM. See LaRusso NF Effect of Capsaicin in the Rat, Lenz HJ, Zimmerman FG, Messmer B. Lipp RW. See Wildling R 104:1371 Regulation of Canine Gallbladder Lloyd JK. See Portmann B LaMont JT. Motility by Brain Peptides, 104:1678 Lo K-J. See Lee S-D See Pothoulakis C Leopolder-Ochsendorf A. See Protzer U Locher J. See Schmassmann A This Month in Gastroenterology, 104:1, Lerch MM, Saluja AK, Dawra R, Ramarao Loeper J, Descatoire V, Maurice M, 104:335, 104:671, 104:953, 104:1247, P, Saluja M, Steer ML. Are Early Beaune P, Belghiti J, Houssin D, 104:1587 Electron-Microscopic Acinar Cell Ballet F, Feldmann G, Guengerich Lamouliatte H. See Gendre J-P Derangementsin Opossum Pancreati• FP, Pessayre D. Cytochromes P-450 Lance P. Fecal Occult Blood Tests: What's tis Critical for Coagulative Necrosis in Human Hepatocyte Plasma Mem• New?, 104:1852-e at 7 Days?, 104:1237-c brane: Recognition by Several Auto• Langer M. See Swoboda K Lerch MM, Saluja AK, Dawra R, Saluja M, antibodies, 104:203 Langholz E. High-Risk, Low Mortality in Steer ML. The Effect of Chloroquine Logemann JA. See Kahrilas PJ Chronic Ulcerative Colitis: Explana• Administration on Two Experimen• Lohoues M-J. See Gurbindo C tion. Reply, 104:1241-c tal Models of Acute Pancreatitis, Loiselle j, Wollin A. Mucosal Histamine Langnas A. See Abei M 104:1768 Elimination and Its Effect on Acid Lanspa SJ. See Lynch HT Lerch MM, Saluja AK, Rünzi M, Dawra Secretion in Rabbit Gastric Mucosa, LaRusso NF, Link AM. R, Saluja M, Steer ML. Pancreatic 104:1013 Gaining Acceptance to Gastroenterol• Duct Obstruction Triggers Acute Lok ASF. See Chan T-M ogy: How the Review Process Works, Necrotizing Pancreatitis in the Opos• Lombard M, Portmann B, Neuberger J, 104:1252-e sum, 104:853 Williams R, Tygstrup N, Ranek L, Tempora Mutantur, Nos et Mutamur in Lerebours E. See Gendre J-P Ring-Larsen H, Rodes J, Navasa M, Ulis!, 104:3-e Leung FW. See Endoh K Trepo C, Pape G, Schou G, Badsberg Larzul D. See Marcellin P Leuschner U. See Güldütuna S JH, Andersen PK. Cyclosporin A Lassiter DC. See Ren J Levenson DE, Fromm H. 10 g of Fat per Treatment in Primary Biliary Cir• Launois B. See Deugnier YM Day May Keep Gallstones Away. rhosis: Results of a Long-Term Pla• Laurin J. See Yin J Comment, 104:1880-ss cebo Controlled Trial, 104:519 La Villa G. See Gentilini P Levitt MD. Rat Gastric Antidiuretic Hor• Longcroft j. See Wright NA Lawson DEM. See Walters JRF mone Activity and Ethanol Metabo• Longmire-Cook SJ. See Lillienau J Layden TJ. See Goldstein JL lism, 104:l582-c Lopez J-M. See Deugnier YM June 1993 AUTHOR INDEX 1903

Lopez-Talavera JC. See Sieber CC Manci EA. See Gremse DA Mazzanti R. See Bechi P Losi L. See Benhattar J Mannes GA. See Bayerdörffer E Mazzucco G. See Mondardini A Lowe VC. See Noronha-Blob L Marani S. See DuPont HL McAuliffe C. See Sandler RS Lu R-B. See Zheng B-Y Marcellin P, Descamps V, Martinot- McCullough AJ, Glamour T. Differences Lu S-N. See Chuang W-L Peignoux M, Larzul D, Xu L, Boyer in Amino Acid Kinetics in Cirrhosis, Luca A, Cirera I, Garcia-Pagan JC, Feu F, N, Pham B-N, Crickx B, Guillevin 104:1858-e Pizcueta P, Bosch J, Rodes J. Hemo• L, Beiaich S, Erlinger S, Benhamou McElree CK. See Toyoda H dynamic Effects of Acute Changes in J-P. Cryoglobulinemia With Vasculi• McGill JM. See Basavappa S Intra-abdominal Pressure in Patients tis Associated With Hepatitis C Virus McHenry LJr, Vuyyuru L, Schubert ML. With Cirrhosis, 104:222 Infection, I04:272-cr Helicobacter pylori and Duodenal Ulcer Lucidarme D, Colombel J-F, Brandtzaeg Marchandise X. See Adenis A Disease: The Somatostatin Link? P, Tulliez M, Chaussade S, Marteau Marinucci G. See David E Comment, 104:1573-srr P, Debennin J-P, Vaerman j-P, Markin RS. See Quigley EMM McHugh K. See Grossi L Rambaud J-C. a-Chain disease: Anal• Markowitz NR. See Berenson MM McNeil PL. See Paimela H ysis of a-Chain Protein and Secretory Marra F. See Gentilini P Meddings JB. See May GR Component in Jejunal Fluid, Marra G. See Anti M Meddings JB, Sutherland LR, Byles NI, 104:278-cr Marsh MN. Wallace JL. Sucrose: A Novel Per• Luinetti O. See Rindi G Gluten Sensitivity and Latency: Can meability Marker for Gastroduodenal Luk CT. See Hui WM Patterns of Intestinal Antibody Se• Disease, 104:1619 Lund PK. See Ulshen MH cretion Define the Great 'Silent Ma• Meloche RM. See Buchan AMJ Lüttichau HR, Van Solinge WW, Nielsen jority?', 104:1550-e Meitzer SJ. See Yin j FC, Rehfeld JF. Developmental Ex• See Quigley EMM Menard D, Arsenault P, Monfils S. Matu• pression of the Gastrin and Chole- Marshall S. See Yamada T ration of Human Fetal Stomach in cystokinin Genes in Rat Colon, Marteau P. See Lucidarme D Organ Culture, 104:492 104:1092 Martin P. Hepatitis C: More Than Just a Mendrick DL. See Allan CH Lutton C. See Ferezou J Liver Disease, l(.)4:320-e Menko FH, Te Meerman GJ, Sampson JR. Lyles CM. See Sandler RS Martinez-Sandoval FG. See DuPont HL Variable Age of Onset in Hereditary Lynch HT, Smyrk TC, Watson P, Lanspa Martinot-Peignoux M. See Marcellin P Nonpolyposis Colorectal Cancer: SJ, Lynch JF, Lynch PM, Cavalieri Mary J-Y. See Gendre J-P Clinical Implications, 104:946-c 946 RJ, Boland CR. Genetics, Natural Marzano A. See David E Mennel RG. See Stone MJ History, Tumor Spectrum, and Pa• Mascarenhas MR. See Stahl GE Mentha G. See Borgeat A thology of Hereditary Nonpolyposis Masini E. See Bechi P Meschievitz C. See Lefkowitch JH Colorectal Cancer: An Updated Re• Massie D. See Wong F Messenger J P. See Padbury RTA view, 104:1535-srr Mathewson JJ. See DuPont HL Messmer B. See Lenz HJ Lynch JF. See Lynch HT Matsui J, Cameron RG, Kurian R, Kuo Metman E-II. See Gendre J-P Lynch PM. See Lynch I IT GC, Jeejeebhoy KN. Nutritional, He• Mezey E. Rat Gastric Antidiuretic Hor• Lynn RB. See Altschuler SM patic, and Metabolic Effects of Ca- mone Activity and Ethanol Metabo• chectin/Tumor Necrosis Factor in lism. Reply, 104:1583-c MacPherson AJ. See Bjarnason I Rats Receiving Total Parenteral Nu• Mezey E, Palkovits M. A Potential Role Macrae FA. See St. John DJB trition, 104:235 for the Immune System in Gastric Madanagopalan N. See Victor S Matsumoto M. See Miyasaka K Acid Secretion and Peptic Ulcer Dis• Maes BD. See Ghoos YF Matsuno K. See Yamaguchi Y ease. Reply, 104:1875-ss Magalong D. See Toyoda FI Matsushita K, Okabayashi Y, Hasegawa Middleton J. See Basavappa S Maggiore Q. See Gentilini P H, Koide M, Kido Y, Okutani T, Mieli-Vergani G. See Vergani D Maiese L. See Zheng B-Y Sugimoto Y, Kasuga M. In Vitro In• Mikkelsen HB. See Rumessen JJ Maiese S. See Zheng B-Y hibitory Effect of Somatostatin on Millard S. See Roediger WEW Main C, Blennerhassett P, Collins SM. Secretin Action in Exocrine Pancreas Miller TA. Leiomyosarcoma: Not All Human Recombinant Interleukin lß of Rats, 104:1146 Gastric Malignancies Have a Dismal Suppresses Acetylcholine Release Matsuura T, West GA, Youngman KR, Prognosis. Comment, 104:941-ss From Rat Myenteric Plexus, 104:1648 Klein JS, Fiocchi C. Immune Activa• Mintchev MP, Kingma YJ, Bowes KL. Maiuri L, Raia V, Fiocca R, Solcia E, tion Genes in Inflammatory Bowel Accuracy of Cutaneous Readings of Cornaggia M, Noren O, Sjostrom H, Disease, 104:448 Gastric Electrical Activity, 104:1273 Swallow D, Auricchio S, Dabelsteen Matsuzawa Y. See Kiyobara T Minuk GY, Gauthier T. The Effect of E. Mosaic Differentiation of Human Matuchansky C. See Ferezou J y-Aminobutyric Acid on Hepatic Re• Villus Enterocytes: Patchy Expres• Maurice M. See Loeper J generative Activity Following Partial sion of Blood Group A Antigen in A May GR, Sutherland LR, Meddings JB. Is Hepatectomy in Rats, 104:217 Nonsecretors, 104:21 Small Intestinal Permeability Really Minutello MA. See Botarelli P Makhlouf GM. See Schubert ML Increased in Relatives of Patients Miselis RR. See Altschuler SM Malfertheiner P. See Büchler iM With Crohn's Disease?, 104:1627 Mishra BB. See Mishra L Mangel AW. See Basavappa S Mayer L. See Sperber K Mishra L. See Benya RV 1904 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

Mishra L, Mishra BB, Harris M, Bayless Duodenal Ulcer Disease: The So• O'Brien C. See Lefkowitch JH TM, Muchmore AV. Tn Vitro Cell matostatin Link? Reply, 104:1575-srr Ochsendorf FR. See Protzer U Aggregation and Cell Adhesion Mol• Motta C. See Mosnier P Ochsenkühn T. See Bayerdörffer E ecules in Crohn's Disease, 104:772 Mozwecz H. See Goldstein JL O'Connor MK. See Hsu JJ Mita E. See Hagiwara H Muchmore AV. See Mishra L Ogata I. See Arai M Mitsuoka S. See Tsutsumi T Mugnai L. See Bechi P Ogata S. See Sperber K Mittal RK. See Chen JDZ Muhlhauser RO. See Noronha-Blob L Ogawa M. See Yamaguchi Y Mittal RK, Smith TK. Is Nitric Oxide the Mukhopadhyay DK. See Agarwal DK Oh no A. See Arai M Noncholinergic, Nonadrenergic Mule L. See Kalabakas AA Ohtawa M, Mizumoto A, Hayashi N, Neurotransmitter Responsible for Müller K-M. See Lambrecht N Yanagida K, Itoh Z, Omura S. Lower Esophageal Sphincter Relax• MunozJ. See Lillienau J Mechanism of Gastroprokinetic Ef• ation? Comment, 104:656-ss Murgatroyd PR. See Christi SU fect of EM523, an Erythromycin Miyasaka K, Sazaki N, Funakoshi A, Murray J, Conklin JL, Du C. Is Nitric Derivative, in Dogs, 104:1320 Matsumoto M, Kitani K. Two Oxide the Noncholinergic, Nonadren• Ohto M. See Chuang W-L Mechanisms of Inhibition by Bile on ergic Neurotransmitter Responsible Ohya T, Schwarzendrube J, Busch N, Luminal Feedback Regulation of Rat for Lower Esophageal Sphincter Re• Gresky S, Chandler K, Takabayashi Pancreas, 104:1780 laxation? Reply, 104:657-ss A, Igimi H, Egami K, Holzbach RT. Miyoshi Y. See Ando H Murray JA. See Conklin JL Isolation of a Human Biliary Glyco• Mizrahi S. See Bickel A Mwantembe O. See Choudari CP protein Inhibitor of Cholesterol Mizumoto A. See Ohtawa M Myers S, Bartula L, Kalley-Taylor B. The Crystallization, 104:527

2 Okabayashi Y. See Matsushita K Mochida S. See Arai M Role of Prostaglandin I and Biliary Lipids During Evolving Cholecystitis Okazaki K, Morita M, Nishimori I, Sano Modigliani R. See Gendre J-P in the Rabbit, 104:248 S, Toyonaga M, Nakazawa Y, Mollo F. See David E Mys G. See Ghoos YF Yamamoto Y, Yamamoto Y. Major Mondardini A, Pasquino P, Bernardi P, Histocompatibility Antigen-Re• Aluffi E, Tartaglino B, Mazzucco G, Nagano K. See Tsujii M stricted Cytotoxicity in Inflammatory Verme G, Negro F. Propafenone-In- Nagase H. See Ando H Bowel Disease, 104:384 duced Liver Injury: Report of a Case Nagataki S. See Tsutsumi T O'Keane CJ. See Pothoulakis C and Review of the Literature, Nagler A. See Ilan Y Okuda K. See Kage M 104:1524-cr Nakamura Y. See Ando H Okuno M. See Kiyobara T Monfils S. See Menard D Nakanishi T. See Kiyobara T Okutani T. See Matsushita K Mönnikes H, Schmidt BG, Tache Y. Psy• Nakao K. See Tsutsumi T Oliver MI. See Andreu M chological Stress-Induced Accelerated Nakata K. See Tsutsumi T O'Loughlin E. See Li Z Colonic Transit in Rats Involves Hy• Nakazawa Y. See Okazaki K O'Mahony S. See Choudari CP pothalamic Corticotropin-Releasing Narkewicz MR. See Sokol R Omata M. See Chuang W-L Factor, 104:716 Nathanson MH. See Beuers U Omura S. See Ohtawa M Moody FG, Senninger N, Runkel N. An• Navasa M. See Lombard M Orlando R other Challenge to the Opie Myth, Negro F. See Mondardini A See Tessari P 104:927-e Neuberger J. See Lombard M See Tobey NA Moore EG. See Conrad ME Newkirk C. See Yin j O'Rourke JS. See Ambroze WLJr Moran A. Bowel Rest and Elemental Diet Nielsen FC Ortego TJ. See Lefkowitch JH in Crohn's Disease, 104:1238-c See Lüttichau HR Osaki K. See Hagiwara A More J. See Morteau O See Van Solinge WW Otte JB. See David E Morelli A. See Fiorucci S Nishimori I. See Okazaki K Otto G. See Kadmon M Morita M. See Okazaki K Niu N. See Afdhal NH Ottobrelli A. See David E Morris GP. See Dinda PK Nolan JM. See Scott AM Owen RL. See Kato T Morteau O. Thromboxanes, Indometha- Nordin G, Gerhardt W. Aspartate Ami• Owyang C. See Hasler WL cin, and Experimental Colitis. Reply, notransferase and Iron Status —Lack 104:1891-c of Support for Covariation, 104:665-c Padbury RTA, Furness JB, Baker RA, Morteau O, More J, Pons L, Bueno L. Noren O. See Maiuri L Toouli J,. Messenger JP. Projections Platelet-Activating Factor and Inter- Norfleet RG. Gastroduodenoscopy for of Nerve Cells From the Duodenum leukin 1 Are Involved in Colonic Familial Adenomatous Polyposis?, to the Sphincter of Oddi and Gall• Dysmotility in Experimental Colitis 104:666-c bladder of the Australian Possum, in Rats, 104:47 Noronha-Blob L, Lowe VC, Muhlhauser 104:130 Mosnier P, Rayssiguier Y, Motta C, RO, Burch RM. NPC 15669, an In• Paimela H, Goddard PJ, Carter K, Khakee Pelissier E, Bommelaer G. Effect of hibitor of Neutrophil Recruitment, R, McNeil PL, Ito S, Silen W. Resti• Ethanol on Rat Gastric Surfactant: Is Efficacious in Acetic Acid-Indiced tution of Frog Gastric Mucosa In A Fluorescence Polarization Study, Colitis in Rats, 104:1021 Vitro: Effect of Basic Fibroblast 104:179 Nuutinen H. See Abei M Growth Factor, 104:1337 Moss SF, Calam J. Helicobacter pylori and Nwokolo CU. See Pounder RE Palkovits M. See Mezey E June 1993 AUTHOR INDEX 1905

Palmer R. See Karlstadt RG Pizcueta P. See Luca A Quiroga J. See Fernandez CM Pamberger P. See Swoboda K PolakJM. See Walters JRF Qvortrup K. See Rumessen JJ Pape G. See Lombard M Polidoro D. See Fox JG Paris JC See Van Kruiningen HJ Pollock DJ. See Kalabakas A A Rachmilewitz D. See Youngman KR Park Y. See Hoofnagle JH Polter D. See Stone MJ Raggi VC See Gentilini P Parquet M. See Ferezou J Pons L. See Morteau O Rahier J. See David E Pascaud XB. See Riviere PJM Ponz de Leon M. See Sassatelli R Raia V. See Maiuri L Pascaud XB, Chovet M, Soulard P, Popovic OS. See Djordjevic D Ramarao P. See Lerch MM Chevalier E, Roze C, Junien J-L. Ef• Pories SE, Weber TK, Simpson H, Rambaud J-C. See Lucidarme D fects of a New y Ligand, JO 1784, Greathead P, Steele G Jr, Ramsay MAE. See Stone MJ on Cysteamine Ulcers and Duodenal Summerhayes IC. Immortalization Ranek L. See Lombard M Alkaline Secretion in Rats, 104:427 and Neoplastic Transformation of Rattner DW. See Ryan CM Pasquino P. See Mondardini A Normal Rat Colon Epithelium: An Raud J, Lindbom L. Leukocyte Rolling Paster BJ. See Fox JG In Vivo Model of Colonic Neoplastic and Firm Adhesion in the Microcir• Paumgartner G Progression, 104:1346 culation, I04:310-e See BayerdörfTer E Porter AJ. See Kalabakas AA Rayford PL. See Doi R See Beuers U Porter J. See Eberer AJ Rayssiguier Y. See Mosnier P Pawlik W. See Konturek SJ Portmann B. See Lombard M Razandi M. See Hiraishi H Payne J. See Lefkowitch JH Portmann B, Stewart S, Higenbottam TW, Real FX. See Gambüs G Pearson PJ. See Thirlby RC Clayton PT, Lloyd JK, Williams R. Reddy RK. See Liang TJ Peer A. See Broide E Nodular Transformation of the Liver Reddy SP. See Tobey NA Pelckmans PA. See Boeckxstaens GE Associated With Portal and Pulmo• Redford A. See Toyoda H Pelissier E. See Mosnier P nary Arterial Hypertension, 104:616- Regenstein F. See Balart LA Pemberton JH. cr RehfeldJF The Problem With Pouchitis, Post AB. Relief of Vection-Induced Mo• See Lüttichau HR 104:1209-e tion Sickness, l04:665-c See Van Solinge WW See Ambroze WLJr Pothoulakis C, Kelly CP, Joshi MA, Gao Reicht G. See HorinaJH Penfold JCB. See St. John DJB N, O'Keane CJ, Castagliuolo I, Reisinger EC. See Wildling R Pentasa Crohn's Disease Study Group. See La M on t J T. Saccbaromyces boulardii I n - Ren j, Young RL, Lassiter DC, Harty RF. Singleton JW hi bits Clostridium difficile Toxin A Calcitonin Gene-Related Peptide Peppercorn MA Binding and Enterotoxicity in Rat Mediates Capsaicin-Induced Neuro• Anorectal Disease in AIDS, 104:1883-br Ileum, 104:1108 endocrine Responses in Rat Antrum, See Singleton JW Poulsom R. See Wright NA 104:485 Pera M, Cameron AJ, Trastek VF, Pounder RE, Nwokolo CU. The Mecha• Rene E. See Gendre J-P Carpenter HA, Zinsmeister AR. In• nism of Bismuth Absorption. Reply, Respondek M. See Lambrecht N creasing Incidence of Adenocarci• 104:1243-c Reyes GR noma of the Esophagus and Esopha• Powell DW. See Argenzio RA See Feray C gogastric Junction, 104:510 Powell LW. See Deugnier YM See Liang TJ Percesepe A. See Anti M Pressman SR. See Toyoda H Reynes M. See Feray C Percy WH, Burton MB, Rose K, Donovan Prieto J. See Fernandez CM Rhim BY. See Behar J V, Burakoff R. In Vitro Changes in Protzer U, Ochsendorf FR, Leopolder- Richter JE. See Singh S the Properties of Rabbit Colonic Ochsendorf A, Holtermüller K-H. Richter WO. See Bayerdörffer E Muscularis Mucosae in Colitis, Exacerbation of Lichen Planus Dur• Riddell RH. See Vermillion DL 104:369 ing Interferon Alfa-2a Therapy for Riethmüller G. See Lindemann F Perez-Tomas R, Cullere X, Diaz C. Im- Chronic Active Hepatitis C, 104:903- Rikkers LF. See Sorrell WT munohistochemical Localization of cr Rinaldi V. See Angelico M Transforming Growth Factor a in Pucci A. See David E Rindi G, Luinetti O, Cornaggia M, the Developing Rat Colon, 104:789 Purcell RH. The Discovery of the Hepati• Capella C, Solcia E. Three Subtypes Perrault J. See Sokol R tis Viruses, !04:955-ceig of Gastric Argyrophil Carcinoid and Perrillo RP the Gastric Neuroendocrine Carci• See Balart LA Quigley EMM noma: A Clinicopathologic Study, See Lefkowitch JH Aluminum and Hepatobiliary Compli• 104:994 Pesciullesi E. See Gentilini P cations of Triphosphopyridine Nu• Ring-Larsen H Peskar BM. See Lambrecht N cleotide. Reply, 104:1583-c See Henriksen JH Pessayre D. See Loeper J See Sorrell WT See Lombard M Petritsch W. See HorinaJH Quigley EMM, Marsh MN, Shaffer JL, Rio M-C. See Wright NA Pham B-N. See Marcellin P Markin RS. Hepatobiliary Complica• Rivera F. See Asbert M Piat C. See Angelico M tions of Total Parenteral Nutrition, Riviere PJM, Pascaud X, Chevalier E, Pike C. See Wright NA 104:286-srr Le Gallou B, Junien J-L. Fedotozine Pinzani M. See Gentilini P Quirke P. See Bell SM Reverses Ileus Induced by Surgery or 1906 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

Perotonitis: Action at Peripheral K- Sagar P. See Bell SM Schiff ER. Opioid Receptors, 104:724 Said HM, Thuy LP, Sweetman L, See Lefkowitch JH Rizzetto M. See David E Schatzman B. Transport of the Biotin See Liang TJ Roberts IM. Hyperlipidemic Gestational Dietary Derivative Biocytin (N-Bio- Oxford Textbook oj Clinical Hepatology, Pancreatitis, 104:1560-e tinyl-L-lysine) in Rat Small Intestine, 104:1232-br Robertson J. See Henry D 104:75 Schlimok G. See Lindemann F Robins-Browne R. See Li Z Sakakura C. See Hagiwara A Schmassmann A, Fehr HF, Locher J, Robinson MG. See Singleton JW Sakamoto M. See Gondo K Lillienau J, Schteingart CD, Rossi SS, Roddenberry J. See Balart LA Sakisaka S. See Gondo K Hofmann AF. Cholylsarcosine, a Rodes j Salapatek AMF, Diamant NE. Assessment New Bile Acid Analogue: Metabo• See Asbert M of Neural Inhibition of the Lower lism and Effect on Biliary Secretion See Lombard M 519 Esophageal Sphincter in Cats With in Humans, 104:1171 See Luca A Esophagitis, 104:810 Schmid CR. See Horina JH Roediger WEW, Duncan A, Kapaniris O, Salizzoni M. See David E Schmidt BG. See Mönnikes H Millard S. Reducing Sulfur Com• Salo J. See Asbert M Schmidt J. See Ryan CM pounds of the Colon Impair Colono- Saluja AK. See Lerch MM Schmidt LN. See Goldstein JL cyte Nutrition: Implications for Ul• Saluja M. See Lerch MM Schnedl WJ. See Wildling R cerative Colitis, 104:802 Samowitz WS. See Berenson MM Schneider BL. See Sokol R Rofman ES. Alcoholism in North America, Sampliner RE. Schoen RE, Brandt LJ. A 19-Year-Old Europe, and Asia, 104:663-br Gastrointestinal Emergencies, 104:331 -br Woman With Unexplained Vomit• Rogers JH. See Walters JRF See Lefkowitch JH ing, l04:302-cch Rolle K. See Büchler M Sampson JR. See Menko FH Schölmerich j. See Büchler M Rolny P. Normal Manometry Results in Samuel D. See Feray C Schou G. See Lombard M Group I Sphincter of Oddi Dyskine• Sanderson IR, Walker WA. Uptake and Schreiber F. See Wildling R sia Patients, 104:1243-c Transport of Macromolecules by the Schteingart CD. See Schmassmann A Romanelli RG. See Gentilini P Intestine: Possible Role in Clinical Schubert ML Ronis MJJ. See Hakkak R Disorders (an Update), l04:622-srr See McHenry L jr Rose K. See Percy WH Sandler RS. See Drossman DA See Shamburek RD Rossi RL. See Asbun HJ Sandler RS, Lyles CM, McAuliffe C, Schubert ML, Makhlouf GM. Gastrin Se• Rossi SS. See Schmassmann A Woosley JT, Kupper LL. Cigarette cretion Induced by Distension Is Rothbaum RJ. See Sokol R Smoking, Alcohol, and the Risk of Mediated by Gastric Cholinergic and Rotter JI Colorectal Adenomas, 104:1445 Vasoactive Intestinal Peptide Neu• See Toyoda H Sanghvi B. See Lefkowitch JH rons in Rats, 104:834 See Treem WR Sano S. See Okazaki K Schuffler MD. See Krishnamurthy S Roucloux I. See Byl B Santa Ana CA. See Eberer AJ Schwarzendrube J. See Ohya T Roze C. See Pascaud XB Santrach PJ. See Czaja AJ Scott AM, Kellow JE, Shuter B, Nolan Ruddy S. See Shamburek RD Santucci L. See Fiorucci S JM, Hoschl R, Jones MP. Effects of Rumessen JJ, Mikkelsen HB, Qvortrup K, Sarr MG. See Stark ME Cigarette Smoking on Solid and Liq• Thuneberg L. Ultrastructure of In• Sarraf C. See Wright NA uid Intragastric Distribution and terstitial Cells of Cajal in Circular Sartor RB Gastric Emptying, 104:410 Muscle of Human Small Intestine, See Drossman DA Scott N. See Bell SM 104:343 See Yamada T Scully LJ, Toze C, Sengar DPS, Goldstein Runkel N. See Moody FG Sasaki Y. See Tsujii M R. Early-Onset Autoimmune Hepati• Rünzi M. See Lerch MM Sassatelli R, Bertoni G, Serra L, Bedogni tis Is Associated With a C4A Gene Russell AS. See Bjarnason I G, Ponz de Leon M. Generalized Deletion, 104:1478 Russo P. See Gurbindo C Juvenile Polyposis With Mixed Pat• Seidel ER. Polyamines in the Gastrointestinal Rustgi AK. Molecular Genetics and Colo• tern and Gastric Cancer, 104:910-cr Tract, 104:1577-br rectal Cancer. Comment, 104:1224-ss Sata M. See Gondo K Seidman E. See Gurbindo C Rutgeerts PJ. See Ghoos YF Sazaki N. See Miyasaka K Sengar DPS. See Scully LJ Ryan CM, Schmidt J, Lewandrowski K, Scapa E. See Broide E Senninger N. See Moody FG Compton CC, Rattner DW, Warshaw Scevens M. See David E Sergi G. See Tessari P Schapiro RH. See Chung RT Serra L. See Sassatelli R AL, Tompkins RG. Gut Macromo- Schatzman B. See Said HM Shaffer JL. See Quigley EMM lecular Permeability in Pancreatitis Scheiman JM. See Boland CR Shamburek RD, Ruddy S, Schubert ML. Correlates With Severity of Disease Scheppach W. See Christi SU Omeprazole and Neutrophil Func• in Rats, 104:890 Scheuermann DW, Timmermans J-P. tion. Comment, 104:939-ss Differing Chemical Content of the Shames B. See Fox JG Sabbah S. See Gurbindo C Neuronal Populations of Submucosal Shanahan F. Safary A. See Lee S-D Ganglionic Plexuses of the Enteric Food Allergy: Fact, Fiction, and Fatal• Säfsten B. See Flemström G Nervous System, 104:1579-c ity. Comment, 104:1230-ss June 1993 AUTHOR INDEX 1907

See Bernstein CN Smith TK. See Mittal RK Steers JL. See Gores GJ See Toyoda H Smyrk TC. See Lynch HT Steinberg H. High-Risk, Low Mortality in Shanahan F, Anton PA. A Potential Role Snow JC. See Goldstein JL Chronic Ulcerative Colitis: Explana• for the Immune System in Gastric Soediono P, Belai A, Burnstock G. Pre• tion, 104:1241-c Acid Secretion and Peptic Ulcer Dis• vention of Neuropathy in the Pyloric Steinberg W. See Borum M ease. Comment, I04:1874-ss Sphincter of Streptozotocin-Diabetic Stephens RB. See Attwood SEA Shanahan F, Bernstein CN. Odd Forms of Rats by Gangliosides, 104:1072 Stern RM, Hu S, Koch KL. Relief of Vec- Inflammatory Bowel Disease: What Sokol RJ, Butler-Simon N, Conner C, tion-Induced Motion Sickness. Can They Tell Us? Comment, Heubi JE, Sinatra FR, Suchy FJ, Reply, 104:665-c 104:327-ss Heyman MB, Perrault J, Rothbaum Stewart S. See Portmann B Shaw-Stiffel TA. See Alam Afridi S RJ, Levy J, Iannaccone ST, Schneider Stiel D. See Li Z BL, Koch TK, Narkewicz MR. Mul- Shea JA. See Asbun HJ St. John DJB, Young GP, AlexeyefT MA, ticenter Trial of D-a-Tocopheryl Sherlock S. The Kidneys in Hepatic Cir• Deacon MC, Cuthbertson AM, Polyethylene Glycol 1000 Succinate rhosis: Victims of Portal-Systemic Macrae FA, Penfold JCB. Evaluation for Treatment of Vitamin E Defi• Venous Shunting (Portal-Systemic of New Occult Blood Tests for de• ciency in Cholestatic Children, Nephropathy), 104:931-e tection of Colorectal Neoplasia, 104:1727 Shiau Y-F. See Stahl GE 104:1661 Shieh YSC. See Balart LA Sola R. See Andreu M Stöckmann F. See Büchler M Shields HM. Ham Popper: A Tribute, Solcia E Stone MJ, Klintmalm GBG, Polter D, 104:331-br See Lamberts R Husberg BS, Mennel RG, Ramsay Shim K-S. See Balart LA See Maiuri L MAE, Flemens EE, Goldstein RM. Shi ma M. See Tsutsumi T See Rindi G Neoadjuvant Chemotherapy and Shinomura Y. See Kiyobara T Sittensen TIA. See Henriksen JH Liver Transplantation for Hepatocel• Shoubayashi S. See Hagiwara A Sorrell WT, Quigley EMM, Jin G, lular Carcinoma: A Pilot Study in 20 Shouval D. See Ilan Y Johnson TJ, Rikkers LF. Bacterial Patients, 104:196 Shtamler B. See Bickel A Translocation in the Portal-Hyper• Strasberg SM. See Harvey PRC Shuster JR. See Botarelli P tensive Rat: Studies in Basal Condi• Strüber HG. See Lamberts R Shuter B. See Scott AM tions and on Exposure to Hemor• Suchy FJ. See Sokol R Sieber CC, Lopez-Talavera JC, Groszmann rhagic Shock, 104:1722 Sugimoto T. See Hiraishi H RJ. Role of Nitric Oxide in the In Soudah HC. See Hasler WL Sugimoto Y. See Matsushita K Vitro Splanchic Vascular Flyporeac- Soulard P. See Pascaud XB Summerhayes IC. See Pories SE tivity in Ascitic Cirrhotic Rats, Soule J-C. See Gendre J-P Sutherland LR 104:1750 Spechler SJ. Laser Photoablation of See May GR Silen W. See Paimela H Barrett's Epithelium: Burning Issues See Meddings JB Silly H. See HorinaJH About Burning Tissues, 104:1855-e Silva MO. See Liang TJ Specian RD. See Yamada T SvanvikJ. See Abei M Silvers SM. See Tobey NA Spengler U. See Beuers U Swain CP. See Kalabakas AA Silverstein F. Microwaves and the Gut, Sperber K, Ogata S, Sylvester C, Alsenberg Swallow D. See Maiuri L 104:926-e J, Chen A, Mayer L, Itzkowitz S. A Sweeting JG Simon PL. See Youngman KR Novel Human Macrophage-Derived Central Blood Volume in Cirrhosis. Simpson H. See Pories SE Intestinal Mucin Secretogogue: Im• Comment, 104:1879-ss Sinatra FR. See Sokol R plications for the Pathogenesis of In• Does the Gallbladder Secrete? Com• Singh S, Richter JE. Alkaline Esophageal flammatory Bowel Disease, 104:1302 ment, 104:329-ss Reflux —A Misnomer, 104:947-c Stahl GE, Mascarenhas MR, Fayer JG Sweetman L. See Said HM Singleton JW, Hanauer SB, Gitnick GL, Shiau Y-F, Watkins JB. Passive Je• Swoboda K, Derfler K, Koppensteiner R, Peppercorn MA, Robinson MG, junal Bile Salt Absorption Alters the Langer M, Pamberger P, Brehm R, Wruble LD, Krawitt EL, Pentasa Enterohepatic Circulation in Imma• Ebringer H, Druml W, Widhalm K. Crohn's Disease Study Group. Mesal- ture Rats, 104:163 Extracorporeal Lipid Elimination amine Capsules for the Treatment of Stamp G. See Wright NA for Treatment of Gestational Hyper• Active Crohn's Disease: Results of a Stark ME, Bauer AJ, Sarr MG, Szurszewski lipidemic Pancreatitis, I04:1527-cr 16-Week Trial, 104:1293 JH. Nitric Oxide Mediates Inhibitory Sylvester C. See Sperber K Sitges-Serra A. See Andreu M Nerve Input in Human and Canine Szathmary M. See Tulassay Z Sjogren MH. The Success of Hepatitis A Jejunum, 104:398 Szurszewski JH. See Stark ME Vaccine, 104:1214-e Starzl TE, Todo S, Tzakis A, FungJ. The Sjostrom H. See Maiuri L Transplantation of Gastrointestinal Slavin S. See Ilan Y Organs, 104:673-ceig Tache Y. See Mönnikes H Small DM. See Afdhal NH Steele G Jr. See Pories SE Taira T. See Tanila H Smedile A. See David E Steer ML Takabayashi A. See Ohya T Smith BF. See Afdhal NH See Borum M Takahashi T. See Hagiwara A Smith N. See Kmiot WA See Lerch MM Takehara T. See Hagiwara H 1908 AUTHOR INDEX GASTROENTEROLOGY Vol. 104, No. 6

Tal ley NJ ciations of HLA Class II Genes With JAA, Lecomte-FIoucke M, Devred See Wolfsen HC Inflammatory Bowel Disease, 104:741 M, Paris JC, Cortot A. An In-Depth See Zighelboim J Toyonaga M. See Okazaki K Study of Crohn's Disease in Two Tamaoki T. See Tsutsumi T Toze C. See Scully LJ French Families, 104:351 Tamburro CH. See Lefkowitch JH Trastek VF. See Pera M Van Maercke YM. See Boeckxstaens GE Tanaka K. See Kiba T Treem WR. See Hyams JS Van Noorden S. See Wright NA Tan don AK. See Genta RM Treem WR, Veligati LN, Rotter J I, Targan Van Solinge WW. See Lüttichau HR Tanikawa K. See Gondo K SR, Hyams JS. Ulcerative Colitis and Van Solinge WW, Nielsen FC, Friis- Tanila H, Kauppila T, Taira T. Inhibition Total Alopecia in a Mother and Her Hansen L, Falkmer UG, Rehfeld JF. of Intestinal Motility and Reversal Son, 104:1187-cr Expression but Incomplete Matura• of Postlaparotomy Ileus by Selective Tremblay L. See Collman PI tion of Progastrin in Colorectal Car•

a2s-Adrenergic Drugs in Rat, 104:819 Trepo C. See Lombard M cinomas, 104:1099 Tarazi EM, Harter JG, Zimmerman H), Trier JS. See Allan CH Van Thiel DH. See Lefkowitch JI1 Ishak KG, Eaton RA. Sulindac-As- Tseng C-C See Wolfe MM Vantrappen G sociated Hepatic Injury: Analysis of Tsuji S. See Tsujii M See Ectors N 91 Cases Reported to the Food and Tsujii M, Kawano S, Tsuji S, Ito T, See Ghoos YF Drug Administration, 104:569 Nagano K, Sasaki Y, Hayashi N, Vaughan RD. See Lefkowitch JH Targan SR Fusamoto H, Kamada T. Cell Ki• Veligati LN. See Treem WR See Toyoda H netics of Mucosal Atrophy in Rat Vergani D, Mieli-Vergani G. Type II Au• See Treem WR Stomach Induced by Long-Term Ad• toimmune Hepatitis. What Is the Tartaglino B. See Mondardini A ministration of Ammonia, 104:796 Role of the Hepatitis C Virus?, Taylor B. See Balart LA Tsuruta S. See Tsutsumi T 104:18 70-e Taylor GR. See Bell SM Tsutsumi T, Nakao K, Mitsuoka S, Verme G Taylor RG. See Fuller PJ Hamasaki K, Tsuruta S, Shima M, See David E Te Meerman GJ. See Menko FH Nakata K, Tamaoki T, Nagataki S. See Mondardini A Terano A. See Hiraishi H Regulation of Albumin and a-Feto• Vermillion DL, HuizingaJD, Riddell RH, Tessari P, Biolo G, Inchiostro S, Orlando protein Gene Expression by Colloid Collins SM. Altered Small Intestinal R, Sergi G. Leucine and Phenylala• Osmotic Pressure in Fluman Hepa• Smooth Muscle Function in Crohn's nine Kinetics in Compensated Liver toma Cells, 104:256 Disease, 104:1692 Cirrhosis: Effects of Insulin, 104:1712 Tulassay T. See Tulassay Z Viar MJ. See Wangj-Y Thirlby RC. More Problems With Aspirin: Tulassay Z, Tulassay T, Szathmary M. Victor S, Jayanthi V, Madanagopalan N. It May Cause Appendicitis. Com• Does Somatostatin Influence Kidney Aetiology of Membranous Obstruc• ment, 104:1571-srr Function in Cirrhosis?, 104:1892-c tion of Inferior Vena Cava, Thirlby RC, Pearson PJ. Nitric Oxide Is Tulliez M. See Lucidarme D 104:1581-c (or Is Not) Everywhere! Comment, Tur-Kaspa R. See Ilan Y Vila MC. See Andreu M 104:658-ss Turlin B. See Deugnier YM ViteauJ-M. See Gendre J-P Thomas HJW. The Timing of p53 Inacti- Tyan D. See Toyoda FI Voyles NR. See Benya RV vation in Chronic Ulcerative Colitis, Tygstrup N. See Lombard M Vuyyuru L. See McHenry LJr 104:1889-c Tzakis A. See Starzl TE Thompson H. See Kmiot WA Waggoner JG. See HoofnagleJH Thompson JC. See Guo Y-S Ueno T. See Gondo K Walker WA Thompson W. See Behar J Uhl W. See Büchler M See Chu S-HW Thuneberg L. See Rumessen JJ Ulshen MH, Dowling RH, Fuller CR, See Sanderson IR Thuy LP. See Said HM Zimmermann EM, Lund PK. En• Wallace JL Timmermans J-P. See Scheuermann DW hanced Growth of Small Bowel in See Hogaboam CM Tobey NA, Reddy SP, Khalbuss WE, Transgenic Mice Overexpressing Bo• See Meddings JB Silvers SM, Cragoe EJ Jr, Orlando vine Growth Hormone, 104:973 Wallaert B. See Adenis A RC. Na+-Dependent and -Indepen• Umbreit JN. See Conrad ME Walters JRF, Bishop AE, Facer P, Lawson

dent C1~/HC03—Exchangers in Unutmaz D. See Botarelli P DEM, Rogers JH, Polak JM. Calre- Cultured Rabbit Esophageal Epithe• tinin and Calbindin-D28k Immuno- lial Cells, 104:185 Vaerman J-P. See Lucidarme D reactivity in the Human Gastrointes• Todo S. See Starzl TE Vanderhaeghen JJ. See Vanderwinden J-M tinal Tract, 104:1381 Tompkins RG. See Ryan CM Vanderhoof JA. Regulatory Peptides and WangJ-Y, Viar MJ, Johnson LR. Trans• Tong Y. See Yin J Intestinal Growth, 104:1205-e glutaminase in Response to Flyper- Toouli J. See Padbury RTA Vanderwinden J-M, Vanderhaeghen JJ, tonic NaCl-Induced Gastric Mucosal Townsend CM Jr. See Guo Y-S De Laet MH. Nitric Oxide Is (or Is Injury in Rats, 104:65 Toyoda H, Wang S-J, Yang H-Y, Redford Not) Everywhere! Reply, 104:659-ss Wang S-J. See Toyoda H A, Magalong D, Tyan D, McElree Van Kruiningen HJ, Colombel JF, Cartun Wang Y-J. See Lee S-D CK, Pressman SR, Shanahan F, RW, Whitlock RH, Koopmans M, Warshaw AL. Targan SR, Rotter JL Distinct Asso• Kangro HO, Hoogkamp-Korstanje Damage Prevention Versus Damage June 1993 AUTHOR INDEX 1909

Control in Acute Pancreatitis, pertrophic Gastropathy or Gastritis?, Yan L. See FoxJG 104:1216-e 104:1310 Yanagida K. See Ohtawa M See Chung RT Wollin A. See Loiselle J Yang H-Y. See Toyoda H See Ryan CM Wong F, Massie D, Colman j, Dudley F. Yang L, Faris RA, Hixson DC. Long- Watkins JB. See Stahl GE Glomerular Hyperfiltration in Pa• Term Culture and Characteristics of Watson P. See Lynch HT tients With Well-Compensated Alco• Normal Rat Liver Bile Duct Epithe• Waxman I. Endoscopic Retrograde Cholangio• holic Cirrhosis, 104:884 lial Cells, 104:840 pancreatography: Technique, Diagnosis and Wong F, Massie D, Hsu P, Dudley F. Yao B, Hogan DL, Bukhave K, Koss MA, Therapy, 104:944-br Indomethacin-Induced Renal Dys• IsenbergJI. Bicarbonate Transport Weber TK. See Pories SE function in Patients With Well- by Rabbit Duodenum In Vitro: Effect Weiner AJ. See Botarelli P Compensated Cirrhosis, 104:869 of Vasoactive Intestinal Polypeptide,

Weinstock MA. Epidemiology and Prog• WoodJD. See Christof! FL Prostaglandin E2, and Cyclic Adeno• nosis of Anorectal Melanoma, Woolrich AJ, DaSilva MM, Korelitz BL sine Monophosphate, 104:732 104:174 Predominance of Rectosigmoid Neo• Yaouanq J. See Deugnier YM Wenzl H. See Horina JH plasia in Ulcerative Colitis and Its Yarbough PO. See Liang TJ West GA Implication on Cancer Surveillance. Yattoo GN. See Khuroo MS See Matsuura T Reply, 104:667-c Yin J, Harpaz N, Tong Y, Huang Y, See Youngman KR Woosley JT. See Sandler RS Laurin J, Greenwald BD, Hontanosas White P. See Borum M Wright NA, Poulsom R, Stamp G, M, Newkirk C, Meitzer SJ. p53 Point Whitlock RH. See Van Kruiningen Hj Van Noorden S, Sarraf C, Elia G, Mutations in Dysplastic and Cancer• Whittle BJR. Modulation by Prostanoids Ahnen D, Jeffery R, Longcroft j, ous Ulcerative Colitis Lesions, of the Release of Inflammatory Me• Pike C, Rio M-C, Chambon P. Tre• 104:1633 diators From Mast Cells: Involve• foil Peptide Gene Expression in Gas• Yoffe B. See Genta RM ment in Mucosal Protection?, trointestinal Epithelial Cells in In• Yokosuka O. See Chuang W-L 104:314-e flammatory Bowel Disease, 104:12 You T. See Güldütuna S Widhalm K. See Swoboda K Wright TL. Etiology of Fulminant He• Young GP. See St. John DJB Wiebecke B. See Bayerdörffer E patic Failure: Is Another Virus In• Young RL. See Ren J Wilder-Smith OHG. See Borgeat A volved?, 104:640-e Youngman KR. See Matsuura T Wruble LD. See Singleton JW Youngman KR, Simon PL, West GA, Wildling R, Schnedl WJ, Reisinger EC, Wyzga N. See Hyams JS Cominelli F, Rachmilewitz D, Klein Schreiber F, Lipp RW, Lederer A, JS, Fiocchi C. Localization of Intes• Krejs GJ. Agenesis of the Dorsal tinal Interleukin 1 Activity and Pro• Pancreas in a Woman With Diabetes Xu L. See Marcellin P tein and Gene Expression to Lamina Mellitus and in Both of Her Sons, Propria Cells, 104:749 104:1 182-cr Yamada T, Sartor RB, Marshall S, Specian Yu M-Y. See Lee S-D Williams R RD, Grisham MB. Mucosal Injury See Lombard M and Inflammation in a Model of Zargar SA. See Khuroo MS See Portmann B Chronic Granulomatous Colitis in Zheng B-Y, K-M-U, Lu R-B, Maiese L, Wilson JAP. Viral Hepatitis and Liver Dis• Rats, 104:759 Maiese S, Lebenthal E. Absorption ease. Proceedings of the 1990 International Yamaguchi Y, Matsuno K, Goto M, of Glucose Polymers From Rice in Symposium on Viral Hepatitis and Liver Ogawa M. In Situ Kinetics of Acinar, Oral Rehydration Solutions by Rat Disease: Contemporary Issues and Future Duct, and Inflammatory Cells in Small Intestine, 104:81 Prospects, 104:944-br Duct Ligation-Induced Pancreatitis Zighelboim J, Talley NJ. What Are Func• Witte J. See Lindemann F in Rats, 104:1498 tional Bowel Disorders?, 104:1196- Witz E. See Broide E Yamamoto AM, Cresteil D, FlombergJC, vodd Wolf RE. See Asako H Alvarez F. Characterization of Anti- Zimmer G. See Güldütuna S Wolfe MM, Tseng C-C The Gastrin (or Is Liver-Kidney Microsome Antibody Zimmerman FG. See Lenz HJ It CCK-B?) Receptor on the Parietal (anti-LKMl) From Hepatitis C Zimmerman HJ. See Tarazi EM Cell is Cloned. Comment, I04:1877-ss Virus-Positive and -Negative Sera, Zimmermann EM. See Ulshen MH Wolfsen HC, Carpenter HA, Talley NJ. 104:1762 Zinsmeister AR. See Pera M Menetrier's Disease: A Form of Hy• Yamamoto Y. See Okazaki K Zozaya JM. See Fernandez CM SUBJECT INDEX TO VOLUME 104

A2 receptor antagonist, leukocyte-endo- Acupressure, for motion sickness, AGFj ganglioside mixture, in preven• thelial cell adhesive interactions H)4:665-c tion of neuropathy (rat), 104:1072 and (rat), 104:31 Adenocarcinoma AGS cells, insulinlike growth A23187 calcium ionophore atypical juvenile polyposis with, factor-binding protein in modula• FK506 and (rat), 104:1153 104:910-cr tion of growth of, 104:1595 somatostatin and (rat), 104:1146 of esophagus and esophagogastric junc• AIDS. See Acquired immunodeficiency Abdominal pain tion, 104:510 syndrome in agenesis of dorsal pancreas, Adenomatous polyposis coli, genetic Alanine aminotransferase (ALT) 104:1183-cr and molecular diagnosis of, in chronic hepatitis, l()4:665-c in collagenous colitis, 104:906-cr 104:1211-e sinusoidal endothelial cell damage and in essential mixed cryoglobulinemia, Adenosine, leukocyte adhesion and (rat), (rat), 104:1466 104:273-cr 104:31 Albendazole, for hepatic hydatosis, Abdominal pressure, in cirrhosis, Adenosine At receptors, presynaptic 104:1452 104:222 inhibition by (guinea pig), Albumin Abdominal surgery 104:1420 gene expression, colloid osmotic pres• growth of in America, 104:6-ceig Adenosine deaminase, leukocyte-endo- sure in regulation of, 104:256 ileus induced by, fedotozine in reversal thelial cell adhesive interactions in gut lavage fluid, 104:1064 of (rat), 104:724 and (rat), 104:31 in primary biliary cirrhosis, 104:651-e Ablation, of Barrett's epithelium, Adenosine triphosphatase, bacterial in spontaneous bacterial peritonitis, 104:1855-e, 104:1686 toxin interaction with developing 104:954-tmig Acetic acid intestine and, l()4:916-srr in experimental colitis (rat), 104:1021, Adenosine triphosphate (ATP) Alcian Blue staining, anal transition 1049 in colon, 104:690 zone and, 104:514 in peritonitis (rat), 104:724 in transport from hepatocyte into bile Alcohol dehydrogenase (ADH), antidi• Acetylcholine (rat), 104:1507 uretic hormone and (rat), capsaicin-induccd neuroendocrine re• Adenylate cyclase, calmodulin in 104:1582-c sponses and (rat), 104:485 up-regulation of, 104:671-tmig Alcohol, colorectal adenomas and, colitic muscularis mucosae and (rabbit), Adrenaline, for coagulation of bleeding 104:1445 104:369 ulcers (dog), 104:680 Alcoholism gallbladder motility and, 104:563 (^-Adrenergic drugs, intestinal motility cirrhosis and, 104:869, 104:884 interleukin lß and (rat), 104:1648 and (rat), 104:819 liver cancer and, 104:228 Achalasia, nonspecific esophageal motil• Adrenocorticotropic hormone (ACTH), in North America, l^urope, and Asia, ity disorder and, 104:1281 gallbladder motility and (dog), 104:663-br Achlorhydria, prolonged, gastric neopla• 104:1680 Aldosterone sia and, 104:1554-c Afferent nerves arteriovenous shunting and, 104:1 139 Acid phosphatase, in M cells (rat), calcitonin gene-related peptide and in cirrhosis, 104:1485 104:698 (rat), 104:485 Alkaline esophageal reflux, as mis• Acid secretagogues, in gastric mucin gastric hyperemia mechanism and (rat), nomer, l()4:947-c synthesis, 104:1888-c 104:114 Alkaline phosphatase, serum, in primary Acid secretion, mucosal histamine elimi• Age biliary cirrhosis, 104:651-e nation and (rabbit), 104:1013 anorectal melanoma and, 104:174 Alkaline secretion Acinar cells, pancreatic colorectal adenomas and, 104:137, duodenal, JO 1784 and (rat), 104:427 in acute pancreatitis (rat), 104:1498 104:1445 mucosal, dopamine and (rat), 104:825 FK506 and (rat), 104:1153 Crohn's disease and, 104:351 Alopecia, ulcerative colitis and, somatostatin and (rat), 104:1146 hereditary nonpolyposis colorectal 104:1 187-cr Acquired immunodeficiency syndrome cancer and, 104:946-c (AIDS) peptic ulcer and, 104:1083 Aluminum, hepatobiliary complications anorectal disease in, 104:1883-br sulindac-associated hepatic injury and, of triphosphopyridine nucleotide ileal Kaposi sarcoma and, 104:1822-cr 104:569 and, 104:1583-c Alveolar ridge, deglutitive tongue action and, 104:152

KEY TO ABBREVIATIONS American Gastroenterological Associa• aga —American Gastroenterological Asso• c —Correspondence tion ciation e— Editorials Our new president—Don W. Powell, br—Book Reviews paps—Policy and Position Statement M.D., 104:1249 cr—Case Reports ss —Selected Summaries Amiloride cch —Clinical Challenges srr —Special Reports and Reviews endothelin 1 and (rat), 104:1328 ceig—Commemorative Essays in Gastroen• tmig—This Month in Gastroenterology K+ channels and (rabbit), 104:417 terology vodd —Viewpoints on Digestive Diseases pHj regulation and (rabbit), 104:185 June 1993 SUBJECT INDEX 1911

Amino acids to hepatitis C virus, 104:272-cr, Argon laser photoablation, of Barrett's cholesterol crystallization in bile and, 104:556, 104:862 epithelium, 104:1855-e, 104:1686 104:527, 104:539 to hepatitis E virus, 104:556 Argyrophil carcinoid, gastric, subtypes in cirrhosis, 104:1712, 104:1858-e, immortalized colon cell lines and (rat), of, 104:994 I04:1886-c 104:1346 Argyrophil cell hyperplasia, peptic ulcer mobilferrin and (rat), 104:1700 in inflammatory bowel disease, 104:384 disease and, 104:1356 MUC2 apomucin tandem repeat and to insulin (rat), 104:475 Arterial pressure, octreotide effect on (mouse), 104:93 monoclonal (rat), 104:575 transforming growth factor a (rat), in acute pancreatitis (rat), 104:1498 Arteriolar tone, in alcoholic cirrhosis, 104:789 bile duct epithelial cells and (rat), 104:884 y-Aminobutyric acid (GABA), in liver 104:840 Arteriovenous shunting, peripheral, in regeneration (rat), 104:217 M cells and (rat), 104:698 cirrhosis, 104:1 139 5-Aminosalicylic acid MUC2 apomucin tandem repeat and Arthralgias, essential mixed cryoglobu• for Crohn's disease, 104:l247-tmig (mouse), 104:93 linemia and, 104:273-cr neutrophils and, 104:954-tmig Antidiuretic hormone Ascending colon, colonic vagus nerve for ulcerative colitis, 104:326-srr in cirrhosis, 104:1485 and (rat), 104:502 Aminotransferases ethanol metabolism and (rat), Ascites in essential mixed cryoglobulinemia, 104:1582-c in cirrhosis, 104:1133, 104:1139, 104:272-cr Antigens, in mast cell activation (rat), 104:1485, 104:1750 in primary biliary cirrhosis, 104:651-e 104:122 indomethacin and, 104:869 Ammonia, cell kinetics in mucosal atro• Antigliadin antibodies, in celiac disease, low-dose Captopril and, 104:588 phy by (rat), 104:796 104:1263 in pancreatitis (rat), 104:890 Amygdala, central, corticotropin-releas- Antimotility compounds, for diarrhea, in spontaneous bacterial peritonitis, ing factor in (rat), 104:716 104:671-tmig 104:954-tmig Amylase Antinucleating proteins, cholesterol, Asia, alcoholism in, 104:663-br in acute pancreatitis, 104:1768 104:646-e Aspartate aminotransferase (AST), iron pancreatic FK506 and (rat), 104:1153 Antineutrophil cytoplasmic antibodies, status and, 104:665-c somatostatin and (rat), 104:1146 in alopecia with ulcerative colitis, Aspiration, for hepatic hydatosis, Anal transition zone, in ulcerative coli• 104:1187-cr 104:1452 tis, 104:514 Antioxidants, acetic acid-induced colitis Aspirin Anemia, in inflammatory bowel disease, and (rat), 104:1021 appendicitis and, 104:1571-ss erythropoietin for, 104:1828-cr a-l-Antitrypsin, in gut lavage fluid, peptic ulcer and, 104:1083 Anesthetics, for pruritis, 104:l-tmig 104:1064 ulcers and (rat), 104:427 Aneuploidy, in colorectal carcinoma, Antral cells Ataxia, vitamin E deficiency in, 104:57 Helicobacter pylori infection and, 104:1655 104:1587-tmig Angiotensin II somatostatin and, 104:1414 Atipamezole, intestinal motility and Antrofundal redistribution, acute ciga• (rat), 104:819 gallbladder motility and (dog), 104:1680 rette smoking and, 104:410 Atrial natriuretic factor (ANF), in cir• renal hemodynamics in cirrhosis and, Antrum, capsaicin-induced neuroendo• rhosis, 104:1485, 104:l878-ss 104:588 crine responses in (rat), 104:485 Atriopeptin II, gallbladder motility and Anglo-Saxon cultures, alcoholism in, Apamin, inbition of ATP response by, (dog), 104:1680 104:664-br 104:690 Atrophic gastritis, peptic ulcer disease Anorectal melanoma, epidemiology and APC gene and, 104:1356 prognosis of, 104:174 in colorectal cancer, 104:1223-ss Atropine Anorexia, cachectin/tumor necrosis fac• in familial adenomatous polyposis, distension and (rat), 104:834 tor and (rat), 104:235 104:954-tmig, 104:989 endothelin 1 and (rat), 104:1328 Anoxia, in duodenal bicarbonate trans• Apolipoprotein E, gallstones and, JO 1784 and (rat), 104:427 port (rabbit), 104:732 104:1587-tmig, 104:1806 pepsinogen and (guinea pig), 104:1030 Antibiotics, for traveler's diarrhea, Appendectomy, laparoscopic, 104:935-ss ventromedial hypothalamic lesions and 104:671-tmig, 104:709 Appendicitis, aspirin in, 104:1571-ss (rat), 104:475 Antibodies Arachidonic acid, colitic muscularis mu• Atropine methyl nitrate, corticotropin- in alopecia with ulcerative colitis, cosae and (rabbit), 104:369 releasing factor stimulatory activ• 104:1187-cr L-Arginine ity and (rat), 104:716 calcitonin gene-related peptide (rat) calcitonin gene-related peptide and Australia and, 104:1371 (rat), 104:1371 hemochromatosis in, 104:2-tmig in celiac disease, 104:1263 in enteral nutrition, 104:936-ss peptic ulcer in, 104:1083 in Crohn's disease, 104:351, 104:772 lower esophageal sphincter and (opos• Autoantibodies, to cytochrome P-450, to cytochrome P-450, 104:203 sum), 104:1439 104:203 in gluten sensitivity, 104:1550-e in nitric oxide synthesis, 104:672-tmig, Autoimmune disorders, ulcerative colitis to hepatitis B core antigen, 104:549 104:896 and, 104:1187-cr 1912 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Axonal blocker, distension and (rat), Bile acids for (dog), 104:672-tmig, 104:680, 104:834 biodynamics of, after total enterectomy, 104:926-e Azathioprine 104:1786 Bleomycin, for squamous cell cancers, for cryptogenic chronic active hepatitis, in cholecystitis (rabbit), 104:248 104:953-tmig 104:1757 cholylsarcosine and, 104:1 171 Blocking intact inhibition, in esophagitis for primary biliary cirrhosis, 104:651 -e colorectal adenomas and, 104:145 (cat), 104:810 for ulcerative colitis, 104:325-srr gallstone calcification and, 104:1885-c Blood flow Azygos blood flow, in cirrhosis, 104:222 ileal enterocytes in active transport of arteriovenous shunting and, 104:1139 (guinea pig, rat), 104:38 in cirrhosis, 104:222 tauroursodeoxycholic acid and (rat), gastric, epidermal growth factor and 104:604 (rat), 104:1605 Ba2+, serosal, esophageal cell K+ channels pancreatic, nitric oxide in, 104:672- and (rabbit), 104:417 Bile canaliculus, biology of, 1()4:1558-e tmig, 104:896 Bacteria, translocation of in liver disease, Bile diversion, cholesterol and bile acid biodynamics after, 104:1786 rice glucose polymers in oral rehydra• 104:1587-tmig, 104:1722 Bile duct epithelial cell (BDEC) lines, tion solutions and (rat), 104:81 Bacterial toxins, developing intestine normal, establishment of (rat), Blood group A antigen, mosaicism of, and, 104:916-srr 104:840 104:21 Barrett's epithelium, ablation of, Bile ducts, in hepatitis C virus infection, Blood pressure, cyclosporin A and, 104:1855-e, 104:1686 104:595 104:519 Barrett's esophagus Bile reflux, in acute pancreatitis, 104:853 Blood tests esophageal cancer and, 104:510 Bile salts for familial adenomatous polyposis, evolution of, 104:1236-c cyclosporin A and (rat), 104:1507 104:954-tmig molecular events in, 104:1235-c passive absorption of (rat), 104:165 fecal occult, for bowel cancer screening, Basal lamina, in intermediate cells of Biliary cell lines, membrane transport in, I04:1852-e, 104:1661 Cajal, 104:343 104:1796 Body-fundus atrophic gastritis, carci• Basic fibroblast growth factor (bFGF), Biliary lipids, in cholecystitis (rabbit), noids and, 104:994 epithelial restitution and (frog), 104:248 Body mass index (BMI), colorectal ade• 104:1337 Biliary sludge, total parenteral nutrition nomas and, 104:137 Basolateral membranes, ursodeoxycho- and, 104:286-srr Body weight, gallbladder emptying stim• late in stabilization of, 104:1736 Biliary tract, nerve cell projections and uli and, 104:1880-ss B cells, proliferating, a chains and J chain (Australian possum), 104:130 Bolus propulsion, deglutitive tongue ac• in, 104:278 Bilirubin tion and, 104:152 Beer drinking, colorectal adenomas and, in primary biliary cirrhosis, 104:651-e Bombesin 104:1445 in spontaneous bacterial peritonitis, gallbladder motility and (dog), 104:1680 Benzodiazepine analogue, cholecysto- 104:954-tmig, 104:1 133 somatostatin action on (rat), 104:1146 kinin and, 104:1414 Biliopancrcatic duct ligation, in acute Bone marrow P blockers pancreatitis (opossum), 104:853 a-chain protein in, 104:278-cr central blood volume in cirrhosis and, Billroth II subjects, mucosal histamine in colorectal cancer, 104:1225-ss 104:1878-ss content and, 104:1057 transplantation, for hepatitis B, for variceal bleeding, 104:1247-tmig, Bilobular right lung, in agenesis of dorsal 104:1818-cr 104:1460 pancreas, 104:1183-cr Book Reviews Alcoholism in North America, Europe, and Bethanechol, in esophagitis (cat), 104:810 Biocytin, intestinal transport of (rat), Asia, 104:663 Bicarbonate 104:75 Anorectal Disease in AIDS, 104:1883 dopamine and (rat), 104:825 Biotin, dietary derivative of (rat), 104:75 Endoscopic Retrograde Cholangiopancrea• in duodenum, 104:732, 104:1247-tmig, N-Biotinyl-L-lysine, intestinal transport tography: Technique, Diagnosis and 104:1409 of, 104:75 Therapy, 104:944 JO 1784 and (rat), 104:427 Biplane videofluoroscopy, deglutitive The Esophagus, 104:1232 Bicarbonate-buffered saline, tongue action and, 104:152 Gastrointestinal Emergencies, 104:331 leukocyte-endothelial cell adhesive 2',7'-bis(carboxyethyl)-5(6)-carboxy- Guide to Liver Transplantation, 104:1233 interactions and (rat), 104:31 fluorescein (BCECF), pi \t regula• Hans Popper: A Tribute, 104:331 Bilateral subdiaphragmatic vagotomy, tion in esophageal epithelial cells Hepatic Encephalopathy, 104:1576 ventromedial hypothalamic lesions and (rabbit), 104:185 Hepatobiliary Diseases, 104:1882 and (rat), 104:475 Bismuth Lectin Binding to Glycoconjugates of the Hu• Bile absorption mechanism of, 104:1242-c man Gastric Fundus, 104:1883 cholesterol crystallization and, 104:527, for diarrhea, 104:671-tmig Management of Gastrointestinal Diseases 104:539, 104:1515 Bivagotomy, JO 1784 and (rat), 104:427 (volumes 1 and 2), 104:1576 luminal feedback regulation of pancreas Blacks, anorectal melanoma in, 104:174 Oxford Textbook of Clinical Hepatology and (rat), 104:1780 Bladder cancer, MUC2 apomucin tan• (two-volume set), 104:1232 total parenteral nutrition and, 104:286- dem repeat and (mouse), 104:93 Pathology of the Gastrointestinal Tract, srr Bleeding ulcers, microwave endoscopy 104:663 June 1993 SUBJECT INDEX 1913

Poly a wines in the Gastrointestinal Tract, Ca2+ Capsaicin 104:1577 calbindin-D28K and, 104:1381 calcitonin gene-related peptide and Viral Hepatitis and Twer Disease. Proceedings calretinin and, 104:1381 (rat), 104:485, 104:1371 of the 1990 International Symposium on cytosolic, tauroursodeoxycholic acid gastric hyperemia mechanism and (rat), Viral Hepatitis and Liver Disease: and (rat), 104:604 104:114 Contemporary Issues and Future Pros• transglutaminase and (rat), 104:65 nitric oxide and, 104:1371 pects, 104:944 Cachectin, total parenteral nutrition and Captopril, low-dose, renal function in Bovine gallbladder mucin, in choles• (rat), 104:235 cirrhosis and, 104:588 terol monohydrate crystal growth, Caerulein, in pancreatitis (rat), 104:890 Carbachol 104:1515 Calbindin-D28K, immunoreactivity, in in Crohn's disease, 104:1692 Bovine growth hormone, effects of on human gastrointestinal tract, FK506 and (rat), 104:1153 small bowel (transgenic mice), muscle contraction in colitis and (rat), 104:1381 104:973 104:1049 Calcitonin, gallbladder motility and (rat), Bowel rest, in Crohn's disease, 104:1238-c pepsinogen and (guinea pig), 104:1030 104:1680 Bowel cancer, u)-3-fatty acids and, somatostatin and (rat), 104:1146 Calcitonin gene-related peptide 104:1239-c Carbaminoylcholine, in gastric mucin (CGRP) BQ-123, endothelin 1 and (rat), 104:1328 synthesis, 104:1888-c Bradykinin, gallbladder motility and capsaicin-induced neuroendocrine re• Carbohydrate sponses and (rat), 104:485 (dog), 104:1680 cholesterol crystallization promoter in Brain, corticotropin-releasing factor in gallbladder motility and (dog), 104:1678 bile and, 104:539 (rat), 104:716 nitric oxide and, in capsaicin protection total parenteral nutrition and, 104:286- Brainstem (rat), 104:1371 srr innervation of esophagus and (cat), in pyloric sphincter (rat), 104:1072 Carbon particles, adsorbing, in new 104:1430 Calcium drug-delivery format, 104:1037 diarrhea and, 104:709 motoneuronal labeling, colonic vagus Carboxyamidation, of gastrin, 104:1092, endothelin 1 and (rat), 104:1328 nerve and (rat), 104:502 1099 gallbladder motility and, 104:563 Breast cancer, MUC2 apomucin tandem Carcinogenesis, bile duct cells and, Calcium chloride, luminal feedback reg• repeat and (mouse), 104:93 104:840 Breath test, to measure gastric emptying ulation of pancreas and (rat), Carcinoids, identification of, 104:994 of solids, 104:1640 104:1780 Cardiac output, in cirrhosis, 104:222 Bremazocine, in reversal of ileus (rat), Calcium ionophore Case Reports 104:724 FK506 and (rat), 104:1153 Ablation of persistent hepatitis B by in mast cell activation (rat), 104:122 Brctylium, corticotropin-releasing factor bone marrow transplantation from somatostatin and (rat), 104:1 146 stimulatory activity and (rat), a hepatitis B-immune donor, Calcium polycarbophil, for secretory 104:716 104:1818 diarrhea, 104:1007 8-Bromoadcnosine 3:5' cyclic mono• Acute relapsing pancreatitis as a com• Calmodulin inhibitor, for traveler's diar• phosphate, somatostatin action plication of papillary stenosis after on (rat), 104:1146 rhea, 104:671-tmig, 104:709 e n doscop i c sph i ncte rotom y, Brucella spp., in Crohn's disease, 104:351 Calories 104:1814 Brunner's glands, bicarbonate secretion colorectal adenomas and, 104:1445 Agenesis of the dorsal pancreas in a and (rat), 104:825 rice glucose polymers in oral rehydra• woman with diabetes mellitus and Brush border antigens, mosaicism of, tion solutions and (rat), 104:81 in both of her sons, 104:1182 104:21 total parenteral nutrition and, 104:286- Buerger's disease presenting as acute Brush border receptor, ileal, Toxin A srr small bowel ischemia, 104:1192 binding to (rat), 104:1108 Calreticulin, mobilferrin as homologue of a-Chain disease: analysis of d-chain Bs/Nl restriction enzyme digestion, (rat), 104:1700 protein and secretory component K\-ras codon 12 mutations and, Calretinin, immunoreactivity, in human in jejunal fluid, 104:278 104:59 gastrointestinal tract, 104:1381 Chronic pancreatitis: a complication of Buerger's disease, presenting as acute Campylobacter spp., in Crohn's disease, systemic lupus erythematosis, small bowel ischemia, 104:1192-cr 104:351 104:613 Bumetanide, membrane transport and, Canada, alcoholism in, 104:663-br Collagenous colitis in children, 104:906 104:1796 Canalicular membranes, ursodeoxycho- Cryoglobulinemia with vasculitis asso• Burns, bacterial translocation in, late in stabilization of, 104:1736 ciated with hepatitis C virus infec• 104:1587-tmig Cancer family syndrome, hereditary tion, 104:272 w-Butyrate, reducing sulfur compounds nonpolyposis colorectal cancer Exacerbation of lichen planus during and, 104:802 and, 104:1535-srr interferon alfa-2a therapy for Candidiasis, intraluminal pancreatic, chronic active hepatitis C, 104:903 104:1532-cr Extracorporeal lipid elimination for C4A gene deletion C, in early-onset au• Capillaries, mucosal histamine content treatment of gestational hyperlip- toimmune hepatitis, 104:1478 and, 104:1057 idemic pancreatitis, 104:1527 1914 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Generalized juvenile polyposis with Cell migration, in graft acceptance, Chlorpromazine, for diarrhea, 104:714 mixed pattern and gastric cancer, 104:678-ceig Cholangiocarcinoma, genetic hemochro• 104:910 Cell proliferation, gastrointestinal, ven• matosis associated with, 104:228 In situ hybridization and immunohisto- tromedial hypothalamic lesions in Cholangiopancreatography, endoscopic chemical analysis of cytomegalovi- (rat), 104:475 retrograde, 104:944-br

rus-associated ileal perforation, Central blood volume, in cirrhosis, Cholecystitis, prostaglandin I2 and biliary 104:1822 104:1878-ss lipids in (rabbit), 104:248 Intraluminal pancreatic candidiasis Centrifugal motion, deglutitive tongue Cholecystokinin (CCK) presenting as recurrent pancreati• action and, 104:152 developmental expression of in colon tis, 104:1532 Centripetal motion, deglutitive tongue (rat), 104:1092 Nodular transformation of the liver action and, 104:152 in esophagitis (cat), 104:810 associated with portal and pulmo• a-CGRP, gallbladder motility and (dog), FK506 and (rat), 104:1153 nary arterial hypertension, 104:616 104:1680 in pancreatic secretion, 104:672-tmig Propafenone-induced liver injury: re• CGS 21680, synaptic behavior in myen• pepsinogen and (guinea pig), 104:1030 port of a case and review of the teric neurons and (guinea pig), somatostatin and, 104:1414 literature, 104:1524 104:1420 Cholecystokinin A antagonist, JO 1784 Treatment of anemia in inflammatory Gt-Chain disease, secretory component of and (rat), 104:427 bowel disease with recombinant protein in, 104:278-cr Cholecystokinin octapeptide (CCK-8) human erythropoietin, 104:1828 Chemotaxis, omeprazole and, l()4:938-ss in esophagitis (cat), 104:810 Ulcerative colitis and total alopecia in a Chemotherapy gallbladder motility and, 104:563, mother and her son, 104:1187 neoadjuvant, in combined modality 104:1680 Catecholamines, duodenal bicarbonate treatment for liver cancer, 104:196 somatostatin and (rat), 104:1146 secretion and, 104:1409 transendoscopic injection, 104:953-tmig Cholelithiasis, total parenteral nutrition Catechol-O-methyltransferase (COMT) Chenodeoxycholate, solubilization of and, 104:286-srr inhibitor, bicarbonate secretion membrane lipids by, 104:1736 Cholera toxin-horseradish peroxidase and, 104:825, 104:1409 Chenodeoxycholic acid, biodynamics of, tracer, colonic vagus nerve and Cathepsin B, in acute pancreatitis, after total enterectomy, 104:1786 (rat), 104:50 104:1768 Chenodeoxycholylglycine, ileal entero- Cholestasis Caucasians, anorectal melanoma in, cytes in active transport of (guinea cyclosporin and, 104:1558-e 104:174 pig, rat), 104:38 cyclosporin A and (rat), 104:1507 Caveolae, in intermediate cells of Cajal, Chief cells, pepsinogen secretion by itching and, l()4:l-tmig, 104:244 104:343 (guinea pig), 104:1030 total parenteral nutrition and, 104:286- CCK-B receptor, parietal cell, cloning of Children srr (dog), 104:1876-ss alopecia with ulcerative colitis in, ursodeoxycholic acid for, 104:660-ss CD2+ cells, in inflammatory bowel dis• 104:1187-cr vitamin E deficiency in, 104:1587-tmig, ease, 104:384 bacterial toxins in developing intestine 104:1727 CD4 antibodies, in inflammatory bowel and, 104:916-srr Cholestatic syndrome, propafenone in, disease, 104:384 collagenous colitis in, 104:906-cr 104:l524-cr CD4+ cells, in hepatitis C virus, 104:580 Crohn's disease in, 104:351, 104:1285 Cholesterol CD8 monoclonal antibodies, in inflam• generalized juvenile polyposis in, apolipoprotein E and, 104:1587-tmig, matory bowel disease, 104:384 104:910-cr 104:1806 Ceco-colonic spike bursts, IL-lß action hepatitis A vaccine in, 104:1 129 biodynamics, after total enterectomy, on intestinal motility and (rat), pseudo-obstruction in, 104:1398 104:1786 104:377 ulcerative colitis in, 104:1285 ethanol and (rat), 104:179 Cecum vitamin E deficiency in, 104:1 587-tmig, gallbladder motility and, 104:563 colonic vagus nerve and (rat). 104:502 104:1727 high-risk colorectal adenomas and, in Crohn's disease, 104:351 Chlorambucil, for primary biliary cir• 104:137 Cecum palpation, ileus induced by, fe- rhosis, 104:651-e monohydrate crystal growth and, dotozine in reversal of (rat), Chloramphenicol acetyltransferase 104:1515 104:724 (CAT) plasmid transfection, col• Cholesterol crystallization inhibitor, in Celiac disease, immunoproliferative loid osmotic pressure and, 104:256 bile, 104:527, 104:646-e small intestinal disease Chlorisondamine, corticotropin-releas- Cholesterol crystallization promoter, in and,104:1887-c ing factor stimulatory activity and bile, 104:539, 104:646-e Celiacs, potential, intestinal antibodies in, (rat), 104:716 Cholestyramine, active ileal bile acid 104:1263 2-Chloro-N6-cyclopentyladenosine transport and (guinea pig, rat), Cell adhesion molecules, in Crohn's (CCPA), synaptic behavior in 104:38 disease, 104:772 myenteric neurons and (guinea Cholic acid, biodynamics of, after total Cell kinetics pig), 104:1420 enterectomy, 104:1786 of acute pancreatitis (rat), 104:1498 Chloroquine, in acute pancreatitis, Cholinergic neurons, distension and of mucosal atrophy (rat), 104:796 104:1768 (rat), 104:834 June 1993 SUBJECT INDEX 1915

Cholinergic receptors, ventromedial hy• familial adenomatous polyposis and, CK-19, membrane transport and, pothalamic lesions and (rat), 104:954-tmig 104:1796 104:475 fecal occult blood tests for, 104:1661, c-Ki-ras mutation, colorectal carcinoma Cholylsarcosine 104:1852-e and, 104:2-tmig, 104:57 transport, in human biliary cell lines, hereditary nonpolyposis, 104:946-c, 36C1, membrane transport and, 104:1796 104:1796 104:1535-srr cr Cl~-free solutions, in duodenal bicarbon• K-ras mutations in, 104:1044 bacterial toxin interaction with devel• ate transport (rabbit), 104:732 active ileal bile acid transport and oping intestine and, 104:916-srr

_ C1 /HC03~ exchangers, pHj regulation (guinea pig, rat), 104:38 in cryptosporidiosis (pig), 104:440 in esophageal epithelial cells and in biliary secretion, 104:1171 EM EC 0157:117 and (rabbit), 104:467 (rabbit), 104:185 Chromosome 5, in colorectal carcinoma, endothelin 1 and (rat), 104:1328 Clinical Challenges 104:2-tmig molecular genetics of, 104:1223-ss A 19-year-old woman with unexplained Chromosome 5q21, in familial adenoma• MUC2 apomucin tandem repeat and vomiting, 104:302 tous polyposis, 104:954-tmig, (mouse), 104:93 Clostridium difficile Toxin A, Saccharo- 104:989 overnutrition and, 104:137 myces boulardii inhibition of (rat), Chromosome 17, in colorectal carci• p53 overexpression in, 104:57 104:1108 predicting recurrence of, 104:1225-ss noma, 104:2-tmig Clustering, in Crohn's disease, 104:643-e progastrin in, 104:1099 Chromosome 18, in colorectal carci• c-myc oncogene, colorectal carcinoma central representation of (rat), 104:502 noma, 104:2-tmig and, 104:2-tmig cholecystokinin in (rat), 104:1092 Cigarette smoking Coagulative necrosis, in pancreatitis epithelium, immortalization of (rat), colorectal adenomas and, 104:1445 (opossum), 104:1236-c 104:1346 intragastric distribution of a meal and, C02/HC03~ buffer, pH4 regulation in gastrin in (rat), 104:1092 104:410 esophageal epithelial cells and inflammation, nitric oxide in (rat), liver cancer and, 104:228 (rabbit), 104:185 104:759 Circular muscle, intestinal Cocarcinogenesis, in colorectal cancer, MUC2 apomucin tandem repeat and 104:145 interstitial cells of Cajal in, 104:343 (mouse), 104:93 Codon 12, Ki-ras, in colorectal carcinoma, nitric oxide in (dog, human), 104:398 nitric oxide in inhibitory innervation 104:57 Cirrhosis of, 104:690 Coeliaco-mesenteric ganglia, neural abdominal pressure and hemodynamics pseudo-obstruction and, 104:1398 projections and (Australian pos• in, 104:222 reducing sulfur compounds in, 104:802 sum), 104:130 amino acid kinetics in, 104:1712, transforming growth factor a in (rat), Colchicine, for primary biliary cirrhosis, I04:1858-c, 104:1886-c 104:789 104:651-e Captopril and renal function in, 104:588 transit, stress and (rat), 104:716 Colitis central blood volume in, 104:1878-ss Colonocytes, malnourished, 104:802 eicosanoids in (rat), 104:47 cyclosporin A for, 104:519 Colony-stimulating factors (CSFs), for interleukins in (rat), 104:47 cytokines in, 104:1248-tmig chronic inflammatory bowel dis• muscle contraction in (rat), 104:1049 endothelin in, 104:1485 ease, 104:328-srr muscularis mucosae in (rabbit), 104:369 first bleeding in, 104:1460 Colorectal adenomas platelet-activating factor in (rat), 104:47 hyperdynamic circulation in, 104:1579-c alcohol and, 104:1445 thromboxanes and indomethacin in, gastrointestinal hemorrhage and, cigarette smoking and, 104:1445 I04:1891-c 104:1238-c deoxycholic acid levels in, 104:145 trinitrobenzene sulfonic acid in (rat), glomerular filtration rate in, 104:884 high-risk, overweight and, 104:137 104:47 hepatitis B and, 104:1116 Commemorative Essays in Gastroen• Collagenous colitis, in children, interferon alpha for, 104:953-tmig, terology 104:906-cr 104:1116 Development and application of endos• Collagen type IV, in IGF-1 receptor ex• interleukin 6 in, 104:1492 copy, 104:337 pression (rat), 104:1705 kidneys in, 104:931-e, 104:1892-c The discovery of the hepatitis viruses, Collateral blood flow, in cirrhosis, liver cancer and, 104:2-tmig 104:955 104:222 new strategies needed for treatment of, Einteric infections: 50 years of progress, Colloid osmotic pressure, albumin and 104:651-e 104:1589 a-fetoprotein regulation by, NS A ID-induced renal dysfunction in, A short, eclectic history of exocrine 104:256 104:869 pancreatic insufficiency and Colon peripheral arteriovenous shunting in, chronic pancreatitis, 104:1255 cancer 104:1139 The specialization of gastroenterology alcohol and, 104:1445 spontaneous bacteral peritonitis and, in America, 104:6 cigarette smoking and, 104:1445 104:954-tmig, 104:1133 The transplantation of gastrointestinal c-K'\-ras gene mutations in, 104:57 tumor necrosis factor a in, 104:1492 organs, 104:673 deoxycholic acid in, 104:145 Cisternae, in intermediate cells of Cajal, Common channel theory, of acute pan• Duke's classification and, 104:2-tmig 104:343 creatitis, 104:853 1916 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Complementary RNA (cRNA) probes, The mechanism of bismuth absorption, bowel rest and elemental diet in, ileal proglucagon gene expression 104:1242 104:1238-c and (rat), 104:459 iMolecular events in Barrett's metapla• clustering in, 104:643-e Computed tomography (CT), of dorsal sia, 104:1235 familial, 104:351 pancreatic agenesis, 104:1182-cr Normal manometry results in group I gut lavage fluids in, 104:1064 Concanavalin A, interleukin 2 and (rat), sphincter of Oddi dyskinesia pa• HLA class II genes in, 104:741 104:964 tients, 104:1243 immune activation genes in, 104:448 Confocal line scanning microscopy, CO-3 fatty acids and bowel cancer, interleukins in, 104:749, 104:1285 tauroursodeoxycholic acid effects 104:1239 intestinal permeability in, 104:1588- on cytosolic Ca2+ in isolated hepa- Omeprazole and gastric polyposis in tmig, 104:1627, 104:1848-e tocytes and (rat), 104:604 humans, 104:1584 in vitro cell aggregation and cell adhe• Congestion, capillary, mucosal hista• Predominance of rectosigmoid neopla• sion molecules in, 104:772 mine content and, 104:1057 sia in ulcerative colitis and its im• macrophage-derived mucin secreta- Constipation, treatment of, 104:1007 plication on cancer surveillance, gogue in, 104:1302 Core clustering mutations, in chronic 104:666 mesalamine for, 104:435, 104:1293 hepatitis B virus infection, 104:263 Preventing infection in cirrhotics with MHC-restricted cytotoxicity in, 104:384 Coronavirus, in Crohn's disease, 104:351 gastrointestinal hemorrhage, muscle function in, 104:1692 Correspondence 104:1238 odd forms of, l04:327-srr Absence of false elevations with Kodak Rat gastric antidiuretic hormone activ• trefoil peptide gene expression in, Ektachem lipase, 104:1580 ity and ethanol metabolism, 104:12 Aetiology of membranous obstruction 104:1582 Cryoglobulinemia, with vasculitis, hepa• of inferior vena cava, 104:1581 Regulation of canine gastric mucin syn• titis C virus infection associated Alkaline esophageal reflux —a mis• thesis and phospholipid secretion with, 104:272-cr nomer, 104:947 by acid secretagogues, 104:1888 Cryptosporidiosis, prostanoid inhibition Aluminum and hepatobiliary complica• Relief of vection-induced motion sick• of NaCl absorption in (pig), tions of triphosphopyridine nu• ness, 104:665 104:440 cleotide, 104:1583 Renal effects of aminoacid administra• Crypt reduction, intestinal, in a-chain Animal models for Helicobacter pylori, tion in cirrhosis, 104:1886 disease, 104:278-cr 104:1886 Thromboxanes, indomethacin, and ex• Crystal growth assay, cholesterol crys• Are early electron-microscopic acinar perimental colitis, 104:1891 tallization and, 104:527, 104:539 cell derangements in opossum The timing of p53 inactivation in Cutaneous recordings, of gastric electri• pancreatitis critical for coagulative chronic ulcerative colitis, 104:1889 cal activity (dog), 104:1273 necrosis at 7 days?, 104:1236 Upper gastrointestinal bleeding in the CV-6209, endothelin 1 and (rat), 104:1328 Aspartate aminotransferase and iron critically ill, 104:1885 Cyclic adenosine monophosphate status—lack of support for covar• Variable age of onset in hereditary (cAMP) iation, 104:665 nonpolyposis colorectal cancer: in duodenal bicarbonate transport (rab• Biliary acidification and gallstone calci• clinical implications, 104:946 bit), 104:732 fication, 104:1885 Corticosteroids FK506 and (rat), 104:1 153 Bowel rest and elemental diet in for acetic acid-induced colitis (rat), membrane transport and, 104:1796 Crohn's disease, 104:1238 104:1021 somatostatin and (rat), 104:1146 Differing chemical content of the neu• Cyclic guanosine monophosphate ronal populations of submucosal for collagenous colitis, 104:906-cr ganglionic plexuses of the enteric for cryptogenic chronic active hepatitis, (cGMP), in lower esophageal nervous system, 104:1579 104:1755 sphincter, 104:656-ss Does somatostatin influence kidney for ulcerative colitis, 104:326-srr Cycloheximide, interleukin iß effect and function in cirrhosis?, 104:1892 Corticosterone, y-aminobutyric acid in (rat), 104:1648 Evolution of Barrett's esophagus: the liver regeneration and (rat), Cyclo-oxygenase products jury is still out, 104:1236 104:217 in chronic colitis (rat), 104:47 Gastroduodenoscopy for familial ade• Corticotropin-releasing factor (CRF) endothelin 1 and (rat), 104:1328 nomatous polyposis?, 104:666 gallbladder motility and (dog), 104:1680 8-CyclopentyI-l,3-dipropylxanthine, High risk, low mortality in chronic IL-lß action on intestinal motility and leukocyte-endothelial cell adhesive ulcerative colitis: explanation, (rat), 104:377 interactions and (rat), 104:32 104:1241 in stress-induced accelerated colonic 8-Cyclopentyl-l,3-dl-methylxanthine, Hyperdynamic circulation in cirrhosis: transit (rat), 104:716 synaptic behavior in myenteric physiology or pathophysiology?, Corynebacterium parvum, macrophage neurons and (guinea pig), 104:1420 104:1579 activation and (rat), 104:1466 Cyclosporin Immunoproliferative small intestinal Creatinine, serum, in primary biliary for alopecia with ulcerative colitis, disease or celiac disease, 104:1887 cirrhosis, 104:519 104:1187-cr Intestinal involvement in sarcoidosis, Crohn's disease cholestasis and, 104:1558-e 104:947 5-aminosalicylic acid for, 104:1247-tmig for primary biliary cirrhosis, 104:651-e June 1993 SUBJECT INDEX 1917

Cyclosporin A Dendrites, colonic motoneuron (rat), synaptic behavior in myenteric inhibition, of bile salt transport (rat), 104:502 neurons and (guinea pig), 104:1420 104:1507 Deoxycholic acid, serum, colorectal ade• Disaccharidase, rice glucose polymers in for primary biliary cirrhosis, 104:519 nomas and, 104:145 oral rehydration solutions and CYP series isozymes, in small intestine Devazepide, JO 1784 and (rat), 104:427 (rat), 104:81 (rat), 104:1611 Developed countries, cholesterol-super• Distal necrosis, essential mixed cryoglobu• Cysteamine saturated bile in, 104:527 linemia and, 104:273-cr in lower esophageal sphincter relax• Dexamethasone Distension ation, 104:657-ss acetic acid-induced colitis and (rat), gastric secretion induced by (rat), ulcers, JO 1784 for (rat), 104:427 104:1021 104:834 Cysteinyl leukotrienes, cyclosporin A neutrophils and, 104:954-tmig octreotide and, I04:1248-tmig and (rat), 104:1507 ' Dextran, colloid osmotic pressure and, 2,5-Di-(ter/-butyl)-l,4-benzohydro- Cystic fibrosis transmembrane conduc• 104:256 quinone, tauroursodeoxycholic tance regulator (CFTR), mem• Diabetes acid and (rat), 104:604 brane transport and, 104:1796 dorsal pancreas agenesis and, 104:1182- Diuresis, total parenteral nutrition and Cytochrome b„245, omeprazole and, cr (rat), 104:235 104:938-ss pyloric sphincter nerves and (rat), DNA synthesis Cytochrome P-450 104:1072 y-aminobutyric acid in liver regenera• distribution of in small intestine (rat), Diamine oxidase inhibitor, in Crohn's tion and (rat), 104:217 104:1611 disease, 104:1692 ventromedial hypothalamic lesions and in human hepatocyte plasma mem• Diarrhea (rat), 104:475 brane, 104:203 chlorpromazine for, 104:714 Domperidone, bicarbonate secretion and Cytokeratins, in BDEC lines (rat), in collagenous colitis, 104:906-cr (rat), 104:825 104:840 in cryptosporidiosis (pig), 104:440 Dopamine, bicarbonate secretion and, Cytokines phenolphthalein-induced, 104:1007 104:825, 104:1409 animal models and, 104:1202-e zaldiride maleate for, 104:671-tmig, Dopamine receptor agonists, bicarbon• in cirrhosis, 104:1492 104:709 ate secretion and (rat), 104:825 in inflammatory bowel disease, Diet Dorsal pancreas, agenesis of, 104:1182-cr 104:1285 biotin and (rat), 104:75 Dorsal root ganglia, neural projections in predicting mortality in infected cir• in celiac disease, 104:1263 and (Australian possum), 104:130 rhotics, 104:1248-tmig gallstones and, 104:1880-ss Doxorubicin, in combined modality Cytomegalovirus (CMV), ileal perfora• Diffuse esophageal spasm, nonspecific treatment for liver cancer, 104:196 tion and, 104:1822-cr esophageal motility disorder and, DPDPE, ileus and (rat), 104:724 Cytosol, Ca2+ in, tauroursodeoxycholic 104:1281 DQ region, HLA class II molecule, in acid effects on (rat), 104:604 4,4'-Diisothiocyanatostilbene-2,2'-disul- inflammatory bowel disease, Cytotoxicity, T cell-mediated, in inflam• fonic acid (DIDS) 104:671-tmig, 104:741 matory bowel disease, 104:384 in duodenal bicarbonate transport (rab• DR region, HLA class II molecule, in in• bit), 104:732 flammatory bowel disease, Dansylcadaverine, transglutaminase and membrane transport and, 104:1796 104:671-tmig, 104:741 (rat), 104:65 pi Ij regulation in esophageal epithelial Dual isotope gastric scintigraphy, in D cells cells and (rabbit), 104:185 habitual smokers, 104:410 capsaicin-induced neuroendocrine re• Dilatation, capillary, mucosal histamine Duct cells, in acute pancreatitis (rat), sponses and (rat), 104:485 content and, 104:1057 104:1498 Helicobacter pylori infection and, 104:1655 Dil dye, neural projections and (Austra• Duke's classification peptic ulcer disease and, 104:1356 lian possum), 104:130 for colorectal carcinoma, 104:1044 somatostatin and, 104:1414 3,7-Dimethyl-l-propargylxanthine, leu- molecular basis for, 104:2-tmig Deep tendon reflexes, diminished, vita• kocyte-endothelial cell adhesive Duodenum min E deficiency in, 104:1 587-tmig interactions and (rat), 104:32 bicarbonate in, 104:732, 104:1247-tmig, Deferoxamine, hydrogen peroxide dam• 16,16-Dimethyl prostaglandin E2 104:1409 age and (rat), 104:780 (dmPGE2) a-chain protein in, 104:278-cr Deglutitive tongue action, volume ac• in ethanol-induced microvascular injury dopamine in (rat), 104:825 comodation and bolus propulsion, (rabbit), 104:361 EM523 and (dog), 104:1320 104:152 in gastric mucous cells (rat), 104:103 in pancreatitis (rat), 104:890 Deglycosylation, cholesterol crystalliza• in mast cell activation (rat), 104:122 pseudo-obstruction and, 104:1398 tion and, 104:527, 104:539 Dinitrophenol, M cells and (rat), 104:698 ulcers Degranulation, omeprazole and, Diphenhydramine, endothelin 1 and basic fibroblast growth factor and 104:938-ss (rat), 104:1328 (frog), 104:1337 Dehydration, total parenteral nutrition Diploidy, in colorectal carcinoma, 104:57 Helicobacter pylori gastritis and, and (rat), 104:235 l,3-Dipropyl-8-/>-sulfophenylxanthine, 104:1573-ss 1918 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

JO 1784 for (rat), 104:427 Eeukocyte rolling and firm adhesion in EM523, mechanism of gastroprokinetic somatostatin and, 104:1573-ss the microcirculation, 104:310 effect of (dog), 104:1320 Dysplasia, liver cell, in hepatitis C virus Microwaves and the gut, 104:926 Emergencies, gastrointestinal, manage• infection, 104:595 Modulation by prostanoids of the re• ment of, I04:331-br lease of inflammatory mediators Emptying, gastric e antigen, hepatitis B virus mutations from mast cells: involvement in cigarette smoking effects on, 104:410 and, 104:263 mucosal protection?, 104:314 of solids, breath test for measurement Early oral feeding, following removal of New strategies needed for treatment of of, 104:1640 nasogastric tube, 104:324-srr primary biliary cirrhosis?, 104:651 Endocrine cells, peptic ulcer disease and, EDI monoclonal antibody, in acute Permeability in Crohn's disease altered 104:1356 pancreatitis (rat), 104:1498 barrier functions in healthy rela• Endocrine tumors, gastric, subtypes of, Edema tives?, 104:1848 104:994 in acute pancreatitis, 104:1768 The problem with pouchitis, 104:1209 Endoplasmic reticulum, MUC2 apomu- in Menetrier's disease, 104:1310 Progress in orthotopic liver transplan• cin tandem repeat and (mouse), mucosal histamine content and, tation for hepatocellular carci• 104:93 104:1057 noma, 104:317 ß-Endorphin, gallbladder motility and Editorials Prolonged achlorhydria and gastric (dog), 104:1680 Another challenge to the Opie myth, neoplasia: is there a causal rela• Endorphins, transcutaneous nerve stimu• 104:927 tionship?, 104:1554 lation and, 104:665-c Causation of Crohn's disease: the im• Regulatory peptides and intestinal Endoscopic retrograde cholangiopan• pact of clusters, 104:643 growth, 104:1205 creatography, technique, diagno• Cyclosporin, the biology of the bile The success of hepatitis A vaccine, sis, and therapy, 104:944-br canaliculus, and cholestasis, 104:1214 Endoscopic retrograde pancreatog• 104:1558 Tempora Mutantur, nos et mutamur in raphy, of dorsal pancreatic agene• Cytokines and animal models: a com• ill is!, 104:3 sis, 104:1182-cr bined path to inflammatory bowel Type II autoimmune hepatitis. What is Endoscopic sphincterotomy, acute re• disease pathogenesis, 104:1202 the role of the hepatitis C virus?, lapsing pancreatitis after, Damage prevention versus damage 104:1870 I04:18l4-cr control in acute pancreatitis, Will the real cholesterol-nucleating and Endoscopy 104:1216 -antinucleating proteins please development and application of, Differences in amino acid kinetics in stand up?, 104:646 104:337-ceig cirrhosis, 104:1858 Eicosanoids hospital credentialing standards for Etiology of fulminant hepatic failure: is in chronic colitis (rat), 104:47 physicians performing, 104:1563- another virus involved?, 104:640 in cryptosporidiosis (pig), 104:440 paps, 104:1563 Fecal occult blood tests: what's new?, Elderly, intraluminal pancreatic candi• microwave system for (dog), 104:672- 104:1852 diasis in, 104:1532-cr tmig, 104:680, 104:926-e Gaining acceptance to GASTROENTER• Electrical stimulation, for pain relief, short history of, 104:335-tmig OLOGY: How the review process 104:665-c transendoscopic injection chemotherapy works, 104:1252 Electrogastraphy, cutaneous and, 104:953-tmig The genetic and molecular diagnosis of accuracy of (dog), 104:1273 Endosomal-lysosomal system, in M adenomatous polyposis coli, nausea and vomiting of pregnancy and, cells (rat), 104:698 104:1211 104:1569-ss Endothelial adhesion molecule 1 Gluten sensitivity and latency: can pat• Electrolytes, in cryptosporidiosis (pig), (ELAM-1), in inflammatory terns of intestinal antibody secre• 104:440 bowel disease, 104:1568-ss tion define the great 'silent major• Electromyography Endothelial cells, leukocyte adhesion and ity?', 104:1550 IL-lß action on intestinal motility and (rat), 104:31 Hepatitis C: more than just a liver dis• (rat), 104:377 Endothelin ease, 104:320 trinitrobenzene sulfonic acid and (rat), binding site, in liver (rat), 104:1745 Hepatoprotective properties of urso• 104:47 in cirrhosis, 104:1485 deoxycholic acid, 104:1865 Electron-microscopic autoradiography, in liver and intestinal diseases, Hyperlipidemic gestational pancreatitis, of endothelin 1 binding site in 104:1247-tmig 104:1560 liver (rat), 104:1745 Endothelin 1, colonic ion transport and The kidneys in hepatic cirrhosis: vic• Electron paramagnetic resonance (rat), 104:1328 tims of portal-systemic venous spectroscopy, membrane stabili• Endothelium-derived relaxing factor shunting (portal-systemic ne• zation and, 104:1736 (EDRF), in lower esophageal phropathy), 104:931 Electrophoresis, cholesterol crystalliza• sphincter relaxation, 104:657-ss Laser photoablation of Barrett's epithe• tion and, 104:527, 104:539 Endotoxin lium: burning issues about burning Elemental diet, in Crohn's disease, macrophage activation and (rat), tissues, 104:1855 104:1238-c 104:1466 June 1993 SUBJECT INDEX 1919

portal-systemic nephropathy and, receptor, Salmonella typhimurium and, Ethylene glycol-bis(B-amynomethyl 104:932-e 104:326-srr ether)-N,N,N',iV'-tetraacctic Energy, hiocytin and (rat), 104:75 Epithelial cells acid, in isolating chief cells Enkephalins basic fibroblast growth factor and (guinea pig), 104:1030 neural projections and (Australian pos• (frog), 104:1337 Europe, alcoholism in, 104:663-br sum), 104:130 in human fetal stomach, 104:492 Extracellular matrix, in IGF-1 receptor plasma, itching and, 104:1-tmig, 244 in inflammatory bowel disease, 104:12 expression (rat), 104:1705 Enteral nutrition mosaicism of brush border antigens in, Extracorporeal lipid-elimination, for cytochrome P450 distribution in small 104:21 hyperlipidemic pancreatitis, intestine and (rat), 104:1611 MUC2 apomucin tandem repeat and 104:l527-cr, 104:1560-e immune-enhancing supplements with, (mouse), 104:93 104:936-33 pHj regulation in (rabbit), 104:185 Familial adenomatous polyposis Enterectomy, total, cholesterol and bile trefoil peptide gene expression in, A PC gene in, 104:989 acid biodynamics after, 104:1786 104:12 blood test for, 104:954-tmig Enteric infections, 50 years of progess, Epithelial receptors, in a-chain disease, gastroduodenoscopy for, 104:666-c 104:1589-ceig 104:278-cr Fast Blue dye, neural projections and Enteric nerve circuits, from duodenum Erythromycin (Australian possum), 104:130 to biliary tract (Australian pos• EM 523 and (dog), 104:1320 Fat sum), 104:130 pepsinogen and (guinea pig), 104:1030 dietary, gallstones and, 104:1880-ss Enteric pathogens Erythropoietin, for anemia in inflamma• in hepatitis C virus infection, 104:595 in Crohn's disease, 104:351 tory bowel disease, 104:1828-cr Fatty acids epithelial signal transduction mecha• Escherichia coli bowel cancer and, 104:1239-c nisms for invasion and, 104:326-srr binding of to epithelial cells, 104:327-srr enteral nutrition and, l04:936-ss Enteric stimulation, total parenteral nu• EHEC 0157:117, verotoxin and, Fecal occult blood tests, for bowel trition and, 104:286-srr 104:336-tmig, 104:467 cancer screening, 104:1661, Enterochromaffinlike cell carcinoids, enterotoxigenic, in traveler's diarrhea, 104:1852-e gastric endocrine tumors and, 104:671-tmig, 104:709 671 Feces 104:994 E-selcctin, in inflammatory bowel dis• bile acids in, 104:145 Enterocytes ease, 104:1568-ss Helicobacter mustelae in (ferret), 104:86 ileal, in active bile acid transport Esophageal cells in pneumatosis cystoides intestinalis, (guinea pig, rat), 104:38 basolateral K+ channels in (rabbit), 104:392 mosaicism of brush border antigens on, 104:417 in secretory diarrhea, 104:1007 104:21 pHj regulation in (rabbit), 104:185 Fedotozine, in reversal of ileus (rat), villus, mosaic differentiation of, 104:21 Esophagitis, natural inhibition in (cat), 104:724 En tcroglucagon, ph y to hem aggl u t i n i n 104:810 Feedback regulation, pancreas and (rat), Esophagogastric junction, adenocarci• lectin exposure and (rat), 104:1669 104:1780 noma of, 104:510 Enterohepatic circulation, passive je• Feline esophagitis, natural inhibition in Esophagus junal bile salt absorption and (rat), (cat), 104:810 adenocarcinoma of, 104:510 104:165 Fentanyl, ileus and (rat), 104:724 brainstem innervation of (cat), 104:1430 Enterotoxins, secretory, in diarrhea, Ferritin, aspartate aminotransferase and, cancer, peplomycin for, 104:953-tmig, 104:671-tmig, 104:709 104:665-c 104:1037 Fetal stomach, human, in organ culture, Environmental factors, colorectal ade• nonspecific motor disorder of, 104:1281 104:492 nomas and, 104:1445 overview of, 104:1232-br a-Fetoprotein, gene expression, colloid Enzyme immunoassay (EIA), of hepa• Ethanol osmotic pressure in regulation of, titis C virus, 104:862 cytochrome P450 distribution in small 104:256 Enzyme-linked immunosorbent assay intestine and (rat), 104:1611 Fiber-holding agents, for treatment of (ELISA) gastric surfactant and (rat), 104:179 of anti-HEV IgM antibodies, 104:556 intraluminal, jejunal effects of (rabbit), diarrhea, 104:1007 of celiac disease, 104:1263 104:361 Fibrin, in hepatic necrosis (rat), 104:1466 of Crohn's disease, 104:351 metabolism, antidiuretic hormone and Fibroblasts, in acute pancreatitis (rat), of gut lavage fluid, 104:1064 (rat), 104:1582-c 104:1498 of hepatitis A virus, 104:1129 sucrose permeability and, 104:1619 Fiftieth anniversary, of GASTROENTER• of interleukin 6, 104:1285 ulcers and (rat), 104:427 OLOGY, 104:3-e Eosinophilia, sulindac-associated hepatic 5-N-Ethylcarboxamidoadenosine, syn• Finland injury and, 104:569 aptic behavior in myenteric neu• apolipoprotein E and gallstones in, 7-Epicholic acid, biodynamics of, after rons and (guinea pig), 104:1420 104:1587-tmig, 104:1806 total enterectomy, 104:1786 Ethylenediaminetetraacetic acid propofol and hepatic pruritis in, 104:244 Epidermal growth factor (EGF) (EDTA), in colonic inflammation FK506, effects of on exocrine pancreas in gastric blood flow (rat), 104:1605 (rat), 104:759 (rat), 104:1153 1920 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Flow cytometry, colorectal carcinoma gallbladder motility and, 104:563 Gender and, 104:59 total parenteral nutrition and, 104:286- in agenesis of dorsal pancreas, Fluconazole, for intraluminal pancreatic srr 104:1183-cr candidiasis, 104:l532-cr Gangliosides, in prevention of neuropa• in alcoholism, 104:664-br Fluorescence polarization study of eth- thy (rat), 104:1072 in alopecia with ulcerative colitis, anol effect on gastric surfactant Gap junctions, intermediate cells of Cajal 104:1187-cr (rat), 104:179 and, 104:343 in anorectal melanoma, 104:174 Focal nodular hyperplasia, multiple, of in Barrett's esophagus, 104:1686 Gas-liquid chromatography, colorectal liver, 104:616-cr in Buerger's disease, 104:1192-cr adenomas and, 104:145 Food allergy, fact, fiction, and fatality, in colorectal adenomas, 104:137, Gastric acid 104:1229-ss 104:145, 104:1445 immune system and, 104:1874-ss Food and Drug Administration (FDA), in Crohn's disease, 104:351 interleukin 1 inhibition of (rat), 104:377 sulindac assessment by, 104:569 in intraluminal pancreatic candidiasis, JO 1784 and (rat), 104:427 Forskolin, pancreatic FK506 and (rat), 104:1532-cr Gastric argyrophil carcinoid, subtypes 104:1153 in peptic ulcer, 104:1083 of, 104:994 Four-antigen radioimmunoblot assay, in sulindac-associated hepatic injury, Gastric cancer, atypical juvenile polyposis for anti-HCV antibodies, 104:272- 104:569 with, 104:910-cr cr, 104:556 Gene product 9.5, in pyloric sphincter Foveolar hyperplasia Gastric mucosal lesions, transglutamin• (rat), 104:1072 Menetrier's disease and, 104:1310 ase and (rat), 104:65 Generalized juvenile polyposis, with mucosal histamine content and, Gastric polyposis, omeprazole in, mixed pattern and gastric cancer, 104:1057 104:1584-c 104:91-cr France Gastric surfactant, ethanol effect on (rat), Genes Crohn's disease in, 104:351, 104:643-e 104:179 albumin, 104:256 hemochromatosis in, 104:2-tmig Gastrin bovine growth hormone, 104:973 Fulminant viral hepatitis capsaicin-induced neuroendocrine re• cholecystokinin, 104:1092 hepatitis C virus in, 104:549 sponses and (rat), 104:485 a-fetoprotein, 104:256 new virus in, 104:335-tmig, 104:556, carcinoids and, 104:994 gastrin, 104:1092 104:640-e developmental expression of in colon hemochromatosis, 104:2-tmig, 104:228 Functional bowel disease, characteriza• (rat), 104:1092 hepatitis B virus precore/core gene, tion of, 104:ll96-vodd, 104:1196 distension and (rat), 104:834 104:263 Furosemide, endothelin 1 and (rat), gallbladder motility and (dog), 104:1680 ileal glucagon, 104:459 104:1328 in gastric mucin synthesis, 104:1888-c in inflammatory bowel disease, 104:448, peptic ulcer disease and, 104:1356 104:671-tmig, 104:741 Gabexate mesilate, in acute pancreatitis, phytohemagglutinin lectin exposure and in ulcerative colitis, 104:741 Germany, alcoholism in, 104:664-br 104:1165 (rat), 104:1669 Gadolinium chloride, sinusoidal endo• Giant gastric folds, in Menetrier's dis• receptor, parietal cell (dog), 104:1876-ss thelial cell damage and (rat), ease, 104:1310 Gastrinoma, identification of, 104:994 104:1466 Glandular atrophy, in Menetrier's dis• Gastritis Galanin ease, 104:1310 Helicobacter mustelae in (ferret), 104:86 calbindin-D28K and, 104:1381 Gliadin, celiac disease and, 104:1263 Menetrier's disease and, 104:1310 calretinin and, 104:1381 Globin, immune serum, hepatitis A vac• peptic ulcer disease and, 104:1356 gallbladder motility and (dog), 104:1680 cine and, 104:1129 Gastroduodenoscopy, for familial ade• Gallbladder Glomerular filtration rate nomatous polyposis, 104:666-c cholesterol monohydrate crystal growth in alcoholic cirrhosis, 104:884 Gastroenterology, formal specialty rec• and, 104:1515 Captopril and, 104:588 inflammation, mechanisms of acute ognition of, 104:10-ceig indomethacin and, 104:869 (rabbit), 104:248 Gastroesophageal reflux Glucagon, octreotide effect on (rat), motility, inositol triphosphate and, blocking intact inhibition and (cat), 104:575 104:563 104:810 Glucosamine labeling, human fetal mucosal function of, 104:329-srr mucosal injury and, 104:1057 stomach in organ culture and, nerve cell projections and (Australian Gastrointestinal diseases, management 104:492 possum), 104:130 of, 104:1576-br Glucose absorption, Na+-coupled, in Gallstones Gastrointestinal tract, pathology of, cryptosporidiosis (pig), 104:440 apolipoprotein E and, 104:1587-tmig, 104:663-br Glucose oxidase, hydrogen peroxide 104:1806 G cells damage and (rat), 104:780 calcification of, 104:1885-c capsaicin-induced neuroendocrine re• Glucose oxidation, reducing sulfur com• cholesterol crystallization and, 104:527, sponses and (rat), 104:485 pounds and, 104:802 104:539 Helicobacter pylori infection and, 104:1655 Glucose polymers, rice, in oral rehydra• dietary fat and, 104:1880-ss peptic ulcer disease and, 104:1356 tion solutions (rat), 104:81 June 1993 SUBJECT INDEX 1921

Glucose-6-phosphatase, cytochrome with developing intestine and, Hepatic hydatosis, treatment of, P-450 in plasma membrane and, 104:916-srr 104:1452 104:203 Guanylate cyclase inhibitors, in lower Hepatic venous pressure gradient, in y-Glutamyl transpeptidase esophageal sphincter relaxation, cirrhosis, 104:222 in BD EC lines (rat), 104:840 104:656-ss Hepatitis membrane transport and, 104:1796 Gut autoimmune Gluten, sensitivity and latency, 104:1550-e macromolecular permeability of in anti-cytochrome P-450 autoantibod• Gluten-free diet, in celiac disease, pancreatitis (rat), 104:890 ies in, 104:203 104:1263 macromolecular uptakes in, 104:622-srr C4A gene deletion in, 104:1478 Glyceryl trinitrate, in pancreatic secre• trefoil peptides in, 104:12 cryptogenic chronic active hepatitis tion (dog), 104:896 Gut lavage fluid, in inflammatory bowel as form of, 104:1588-tmig, Glychodeoxycholic acid, in pancreatitis disease, 104:1064 (rat), 104:890 104:1755 Glycine, in extension of gastrin and cho- 488H K-agonist, in reversal of ileus (rat), type II, 104:1870-e lecystokinin (rat), 104:1092 104:724 viral Glycogen storage disease Type lb, Hj receptors, gastric hyperemia mecha• discovery of, 104:955 chronic inflammatory bowel dis• nism and (rat), 104:114 liver disease and, 104:944-br vaccines for, 104:962 ease in, 104:328-srr H2 receptor blocker, acid secretion and Glycoprotein inhibitor, human biliary, of (rabbit), 104:1013 Hepatitis A virus (HAV) cholesterol crystallization, 104:527, Haloperidol, JO 1784 and (rat), 104:427 discovery of, 104:957 104:646-e Hans Popper, tribute to, 104:331-br vaccine for, 104:1129, 104:1214-e Glycoprotein promoter, human biliary, Heart failure, right-sided, focal nodular Hepatitis B virus (HBV) of cholesterol crystallization, hyperplasia of liver and, 104:616-cr bone marrow ablation for, 104:1818-cr 104:539, 104:646-e Helicobacter mustelae, fecal, gastric pH cirrhosis with, 104:1116 Glycosylation, MUC2 apomucin tandem in isolation of (ferret), 104:86 fulminant hepatitis and, 104:549 repeat and (mouse), 104:93 Helicobacter pylori gastritis HBV-like viruses and, 104:960 Glycosyltransferases, bacterial toxin in• ammonia in (rat), 104:796 hepatitis C virus and, 104:595 teraction with developing intestine animal models for, 104:1886-c interferon alpha for, 104:953-tmig, and, 104:916-srr antral G cells/D cells and, 104:1655 104:1116 Goblet cells duodenal ulcers and, 104:1573-ss in liver cancer, 104:196 MUC2 apomucin tandem repeat and Helicobacter mustelae and (ferret), 104:86 precore/core mutations in, 104:263 (mouse), 104:93 Menetrier's disease and, 104:1310 Hepatitis C virus (HCV) trefoil peptide expression in, 104:12 Hematoxylin and eosin (H&E) cryoglobulinemia with vasculitis asso• Gonadotropin-releasing hormone endocrine tumors and, 104:994 ciated with, l()4:272-cr (GnRH), gallbladder motility and myenteric plexus and, 104:1398 fulminant hepatitis and, 104:549 HemeSelect test, for bowel cancer (sheep), 104:1680 getting to the core of, 104:335-tmig G proteins, bacterial toxin interaction screening, 104:1661, 104:1852-e interferon alpha for, 104:104:877, with developing intestine and, Hemoccult II test, for bowel cancer 104:903-cr, 104:1472 104:916-srr screening, 104:1661, 104:1852-e liver/kidney microsome type 1 in, Graft acceptance, in organ transplanta• Hemoccult IISENSA test, for bowel 104:1762 tion, 104:677-ceig cancer screening, 104:1661, more than just a liver disease, 104:320-< Graft vs. host disease (GVHD), primary 104:1852-e in non-A, non-B hepatitis, 104:556 biliary cirrhosis and, 104:651-e Hemochromatosis, genetic, link between pathology of infection, 104:595 Granulocyte colony-stimulating factor liver cancer and, 104:2-tmig, in renal tranplant recipients, 104:862 (G-CSF), for chronic inflamma• 104:228 RNA in, 104:671-tmig tory bowel disease, 104:328-srr Hemodynamics, in cirrhosis, 104:222 silent epidemic of, 104:661-ss Granulocyte-macrophagecolony-stim- HemoQuant test, for bowel cancer T-lymphocytes in, 104:580 ulating factor (GM-CSF), for screening, 104:1661, 104:1852-e chronic inflammatory bowel dis• Hemorrhage, gastrointestinal, infection vaccine for, 104:1228-ss ease, 104:328-srr in cirrhotics with, 104:1238-c Hepatitis D virus (HDV) Granuloma, in Crohn's disease, 104:772 Hemorrhagic necrotizing pancreatitis, discovery of, 104:958 Granulomatous colitis, chronic, nitric pancreatic duct obstruction in recurrence of after liver transplantation oxide in (rat), 104:759 (opossum), 104:853 104:1122 Growth hormone, effects of on small Hemorrhagic shock, bacterial transloca• Hepatitis E virus (HEV) bowel (transgenic mice), 104:973 tion in, 104:1587-tmig, 104:1722 discovery of, 104:959 Growth hormone-releasing factor Hepatectomy, partial, y-aminobutyric in non-A, non-B hepatitis, 104:556 (GRF), gallbladder motility and acid effects on liver regeneration Hepatobiliary diseases (rat), 104:1680 after (rat), 104:217 overview of, 104:1882-br Guanine nucleotide-regulatory pro• Hepatic encephalopathy, overview of, total parenteral nutrition and, 104:286 teins, bacterial toxin interaction 104:1576-br srr 1922 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Hepatocellular carcinoma Hospital credentialing standards, for Hypertrophic pyloric stenosis, infantile, combined modality treatment of, physicians who perform endosco• nitric oxide synthase in, 104:658-ss 104:196 pies, 104:1563-paps, 104:1563 Hypochlorhydria, Helicobacter mustelae in genetic hemochromatosis and, 104:2- Hospitalization rates, for peptic ulcer, feces and (ferret), 104:86 tmig 104:1083 Hypolactasia, human adult-type, mosaic• hepatitis B virus and, 104:961 HuH-7 hepatoma cells, human, colloid ism of brush border antigens in, orthotopic liver transplantation for, osmotic pressure in, 104:256 104:21 104:317-e Human spasmolytic polypeptide Hypopharynx, deglutitive tongue action Hepatocytes (hSP), gene expression, in gastro• and, 104:152 cyclosporin A and (rat), 104:1507 intestinal epithelial cells in inflam• Hyposmie stress, esophageal cell K+ cytochrome P-450 in, 104:203 matory bowel disease, 104:12 channels and (rabbit), 104:417 tauroursodeoxycholic acid effect on cy- Humoral immunity, hepatitis C virus Hypotension, arterial, captopril-induced, tosolic Ca2+ in (rat), 104:604 and, 104:580 104:588 Hepatology, clinical, 104:1232-br Hydatid cysts, hepatic, treatment of, Hypothalamus Hepatoma cells, human, colloid osmotic 104:1452 corticotropin-releasing factor in (rat), pressure in, 104:256 Hydrochloric acid, viscous fingering of, 104:716

HEPES buffer, pH; regulation in esoph• through gastric mucin, 104:1878-ss lesions, in gastrointestinal cell prolifer• ageal epithelial cells and (rabbit), Hydrocortisone, acetic acid-induced coli• ation (rat), 104:475 104:185 tis and (rat), 104:1021 Hereditary nonpolyposis colorectal Hydrogen metabolism, in pneumatosis 125I, membrane transport and, 104:1796 cancer cystoides intestinalis, 104:392 IEC-18 cells, IGF-1 receptor expression review of, 104:1535-srr Hydrogen peroxide injury, iron and in (rat), 104:1705 variable age of onset in, 104:946-c superoxide in mediation of (rat), IgA antigliadin antibodies, in celiac Hexamethonium 104:780 disease, 104:1263 bicarbonate secretion and (rat), 104:825 Hyperamylasemia, in acute pancreatitis, IgG, in gut lavage fluid, 104:1064 endothelin 1 and (rat), 104:1328 104:1768 IgM antibodies JO 1784 and (rat), 104:427 Hyperdynamic circulation, in cirrhosis, in celiac disease, 104:1263 High-performance liquid chromatog• 104:1579-c to hepatitis B core antigen, 104:549 raphy (HPLC), cholesterol crys• Hyperemia to hepatitis F virus, 104:556 tallization inhibitor in bile and, mechanism of injury-induced (rat), Ileum 104:539 104:114 in Crohn's disease, 104:351 Hisl4 monoclonal antibody, in acute in pancreatic exocrine secretion, in cryptosporidiosis (pig), 104:440 pancreatitis (rat), 104:1498 104:672-tmig cytochrome P450 in (rat), 104:1611 Hispanics, alcoholism in, 104:664-br Hypergastrinemia enterocytes, in active bile acid transport Histamine carcinoids and, 104:994 (guinea pig, rat), 104:38 in Crohn's disease, 104:1692 peptic ulcer disease and, 104:1356 growth, phytohemagglutinin lectin and elimination of, (rabbit), 104:1013 Hyperglycemia, total parenteral nutri• (rat), 104:1669 ethanol-induced microvascular injury tion and (rat), 104:235 perforation, cytomegalovirus and, and (rabbit), 104:361 Hyperlipidemia, in pancreatitis, 104:1822-cr in gastric mucin synthesis, 104:1888-c 104:1527-cr, 104:156()-e proglucagon gene expression in (rat), gastric mucosal injury and, 104:1057 Hyperosmolality, total parenteral nutri• 104:459 prostaglandins and (rat), 104:122 tion and (rat), 104:235 pseudo-obstruction and, 104:1398 Histone H3 probes, ileal proglucagon Hyperplasia Saccharomyces boulardii inhibition of 'Toxin gene expression and (rat), 104:459 liver, 104:616-cr A effects in (rat), 104:1108 HLA class II genes, in inflammatory neuroendocrine cell, 104:12 Ileus reversal

bowel disease, 104:671-tmig, Hyperpolarization a2-adrenergic drugs for (rat), 104:819 104:741 lower esophageal sphincter and (opos• fedotozone for (rat), 104:724 HLA-DR antigens, interleukin 1 and, sum), 104:1439 Immortalization, of colon epithelium 104:749 nitric oxide and (dog, human), 104:398 (rat), 104:1346 HLA haplotypes, Crohn's disease and, Hypersensitivity-type reaction Immune activation genes, in inflamma• 104:351 in Crohn's disease, 104:772 tory bowel disease, 104:448 HLA phenotype sulindac-associated hepatic injury and, Immune system in alopecia with ulcerative colitis, 104:569 in gastric acid secretion and peptic ulcer 104:1187-cr Hypertension, cyclosporin A and, disease, 104:1874-ss in cryptogenic chronic active hepatitis, 104:519 macromolecular uptakes in gut and, 104:1588-tmig, 104:1755 Hypertrophic gastropathy 104:622-srr Hong Kong, HCV RNA levels after renal carcinoids and, 104:994 Immunocytes, in a-chain disease, transplants in, 104:671-tmig Menetrier's disease and, 104:1310 104:278-cr Hormones, somatostatin action on (rat), Hypertrophic lymphocytic gastritis, Immunoelectron microscopy, trefoil 104:1146 Menetrier's disease and, 104:1310 peptides and, 104:12 June 1993 SUBJECT INDEX 1923

Immunohistochemical analysis interleukin 6 in, 104:1285 Interferon alpha cytomegalovirus-associated ileal perfo• macrophage-derived mucin secretago- essential mixed cryoglobulinemia and, ration and, 104:1822-cr gue in, 104:1302 104:272-cr p53 overexpression and, 104:57 mesalamine for, 104:435 for cirrhosis, 104:953-tmig, 104:1116 transforming growth factor a and (rat), MHC-restricted cytotoxicity in, 104:384 for hepatitis B, 104:595, 104:953-tmig, 104:789 muscularis in (rabbit), 104:369 104:1116 trefoil peptides and, 104:12 neutrophils in (rat), 104:953-tmig, for hepatitis C, 104:580, 595, 104:672- Immunonutrition, enteral nutrition and, 104:1021 tmig, 104:877, 104:1472 104:936-ss odd forms of, 104:327-srr Interferon alpha-2a, for hepatitis C, li• Immunoperoxidasc staining T cells in, 104:335-tmig, 104:384, chen planus and, 104:903-cr endocrine markers and, 104:994 104:448 Interleukin 1 (IL-1) membrane transport and, 104:1796 trefoil peptide gene expression in, in chronic colitis (rat), 104:47 Immunoproliferative small intestinal 104:12 intestinal, 104:749 disease (IPSID), celiac disease Inflammatory cells Interleukin lß (IL-lß) and,104:1887-c in acute pancreatitis (rat), 104:1498 acetylcholine release and (rat), 104:1648 Indocyanine green, in glomerular filtra• in cryptosporidiosis (pig), 104:440 in intestinal motility (rat), 104:377 tion rate assessment, 104:884 in hepatitis C virus infection, 104:595 Interleukin 2 (IL-2) Indomethacin Inflammatory infiltrate, in pouchitis, in experimental colitis (rat), 104:964 for chronic colitis (rat), 104:47 104:981 in inflammatory bowel disease, 104:448 in experimental colitis, 104:1891 -c Inflammatory mediators, prostanoids in in ulcerative colitis, 104:448 gastric hyperemia mechanism and (rat), release of from mast cells, Interleukin 6 (IL-6) 104:114 104:314-e in cirrhosis, 104:1492 in cholecystitis (rabbit), 104:248 Influenza, in Crohn's disease, 104:351 in inflammatory bowel disease, in cryptosporidiosis (pig), 104:440 Inhibitory junction potentials 104:1285 IL-lß action on intestinal motility and of lower esophageal sphincter (opos• in predicting mortality in infected cir• (rat), 104:377 sum), 104:1439 rhotics, 104:1248-tmig lamina propria mononuclear cells and nitric oxide and (dog, human), 104:398 Interleukins, in chronic colitis (rat), (rat), 104:964 mIn-labeled granulocyte scanning, of 104:47 renal dysfunction induced by, in cir• inflammatory infiltrate in pouchi• Intermediate filaments, in intermediate rhosis, 104:869 tis, 104:981 cells of Cajal, 104:343

Infants Inositol triphosphate (IP3) Interstitial cells of Cajal, in human small hypertrophic pyloric stenosis in, in restoration of impaired gallbladder intestine, 104:343 104:658-ss motility, 104:563 Intestinal fluid, a-chain protein in, pseudo-obstruction in, 104:1398 tauroursodeoxycholic acid and (rat), 104:278-cr total parenteral nutrition-related chole• 104:604 Intestines stasis and, 104:286-srr In situ hybridization developing, bacterial toxins and, toxigenic diarrhea in, 104:916-srr cytomegalovirus-associated ileal perfo• 104:916-srr, 104:916 Infection, in cirrhotics with gastrointesti• ration and, 104:1822-cr interleukin 1 in, 104:749 nal hemorrhage, 104:1238-c ileal proglucagon gene expression and macromolecular uptakes in, 104:622-srr Inferior vena cava, membranous ob• (rat), 104:459 struction of, 104:1581-c trefoil peptides and, 104:12 mast cells in (rat), 104:122 Inflammation Insulin motility of anal transition zone and, 104:514 in amino acid turnover in cirrhosis, uyadrenergic drugs and (rat), 104:819 in Menetrier's disease, 104:1310 104:1712 IL-lß action on (rat), 104:377 nitric oxide in (rat), 104:759 gallbladder motility and (pig), 104:1680 permeability hypothesis and, 104:1588- Inflammatory bowel disease (IBD) ileal proglucagon gene expression and tmig, 104:1627, 104:1848-e adhesion molecule expression in, (rat), 104:459 regulatory peptides and, 104:1205-e 104:1568-ss ventromedial hypothalamic lesions and in sarcoidosis, 104:947-c anemia in, erythropoietin for, (rat), 104:475 transplantation of, 104:675-ceig 104:1828-cr Insulinlike growth factor-binding pro• Intra-abdominal pressure, in cirrhosis, clustering in, l04:643-e tein, in AGS cell growth, 104:1595 104:222 cytokines and, 104:1202-e Insulinlike growth factor 1 (IGF-1) Intragastric distribution, cigarette smok• diarrhea in, I04:671-tmig, 104:671 expression, extracellular matrix effect ing effects on, 104:410 familial, 104:351 on (rat), 104:1705 Intrahepatic cholestasis of pregnancy, genes in, 104:671-tmig, 104:741 small bowel and (transgenic mice), ursodeoxycholic acid for, 104:660- gut lavage fluids in, 104:1064 104:973 ss HLA class II genes in, 104:741 Integrins, effect of leumedins on, Intraluminal manometry, deglutitive immune activation genes in, 104:448 l04:953-tmig tongue action and, 104:152 interleukin 1 in, 104:749 Interferon, recombinant, for cryptogenic In vitro cell aggregation, in Crohn's dis• interleukin 2 in (rat), 104:964 chronic active hepatitis, 104:1757 ease, 104:772 1924 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Ionomycin, membrane transport and, Kaposi sarcoma, ileal, 104:1822-cr Latitude, anorectal melanoma correlated 104:1796 Ketotifen with, 104:174 Ion transport ethanol-induced microvascular injury L cells, intestinal, ileal proglucagon gene bacterial toxin interaction with devel• and (rabbit), 104:361 expression and (rat), 104:459 oping intestine and, 104:916-srr, in mast cell activation (rat), 104:122 LDQ10 monoclonal antibody, MUC2 104:916 Kidneys apomucin tandem repeat and EH EC 0157:H7 and (rabbit), 104:467 in agenesis of dorsal pancreas, (mouse), 104:93 endothelin 1 and (rat), 104:1328 104:1183-cr Lectin affinity chromatography, choles• Iron status in cirrhosis, 104:884, 104:1139, terol crystallization inhibitor in aspartate aminotransferase and, 104:1886-c, 104:1892-c bile and, 104:527 104:665-c cyclosporin A and, 104:519 Lectins, binding of, to glycoconjugates of in genetic hemochromatosis link with endothelin in, 104:1485 human gastric fundus, 104:1883-br liver cancer, 104:2-tmig, 228 in hepatic cirrhosis, 104:931 -e, 104:931 Left-sided tumors, in colorectal carci• hydrogen peroxide damage and (rat), indomethacin and, 104:869 noma, 104:57 104:780 low-dose Captopril and, 104:588 Leiomyosarcoma, long-term survival for, Irritable bowel syndrome (IBS), so• transplantation of 104:940-ss matostatin in, 104:1248-tmig HCV RNA levels after, 104:671-tmig Leucine Ischemia, of small bowel, Buerger's dis• hepatitic C virus infection and, y-aminobutyric acid in liver regenera• ease presenting as, 104:1192-cr 104:862 tion and (rat), 104:217 Isosorbide-5-mononitrate, for variceal Kodak Ektachem lipase, absence of false turnover, in cirrhosis, 104:1858-e, bleeding, 104:1247-tmig, 104:1460 elevations with, 104:l580-c 104:1712 Itching, in cholestasis, 104:1-tmig, Korea, alcoholism in, 104:664-br Leukocyte function associated antigens 104:244 K-ras mutations, in colorectal cancer, (LFAs), in Crohn's disease, 104:1044 104:772 Japan KT1-32, for chronic colitis (rat), 104:47 Leukocyte rolling, and firm adhesion in familial adenomatous polyposis in, microcirculation, 104:310-e 104:954-tmig, 104:989 ß-Lactoglobulin, celiac disease and, Leukocytes HCV RNA and, 104:672-tmig 104:1263 adherence of in mesenteric venules Jaundice Lactulose (rat), 104:31 sulindac-associated hepatic injury and, intestinal permeability to, 104:1588- unsticking of, methotrexate in, 104:1- 104:569 tmig, 104:1627 tmig vitamin E absorption in, 104:1587-tmig in pneumatosis cystoides intestinalis, Leukopenia, during cheomtherapy for J chain, in proliferating B cells, 104:278-cr 104:392 liver cancer, 104:196 Jejunum Lamellae, muscle, intermediate cells of Leukotriene B4 (LTB4), leukocyte-endo- bile salts in, passive absorption of (rat), thelial cell adhesive interactions Cajal and, 104:343 104:165 and (rat), 104:31 Lamina propria bovine growth hormone in (transgenic Leukotriene D4 in collagenous colitis, 104:906-cr, mice), 104:973 in chronic colitis (rat), 104:47 104:906 celiac disease and, 104:1263 in colitic muscularis mucosae (rabbit), in cryptosporidiosis (pig), 104:440 a-chain protein in, 104:278-cr 104:369 interleukin 1 in, 104:749 cytochrome P450 in (rat), 104:1611 Leukotrienes, cyclosporin A and (rat), interleukin 2 in (rat), 104:964 EM523 and (dog), 104:1320 104:1507 mucosal histamine content and, ethanol in (rabbit), 104:361 Leumedins, colon inflammation and 104:1057 growth, phytohemagglutinin lectin and (rat), 104:953-tmig, 104:1021 Laminin, in IGF-I receptor expression (rat), 104:1669 Lichen planus, interferon alpha-2a ther• (rat), 104:1705 M cells in (rat), 104:698 apy and, 104:903-cr Laparoscopy, in appendectomy, 104:935- nitric oxide in (dog, human), 104:398 Life-style factors, colorectal adenomas pseudo-obstruction and, 104:1398 ss and, 104:1445 JO 1784, cysteamine duodenal ulcers and Laparotomy, ileus induced by, fedotozine Light microscopy, of endothelin 1 bind• (rat), 104:427 in reversal of (rat), 104:724 ing site in liver (rat), 104:1745 Large-droplet fat, in hepatitis C virus Lipidapheresis, in hyperlipidemic pan• K+ infection, 104:595 creatitis, 104:1527-cr, 104:1560-e bacterial toxin interaction with devel• Large infranuclear inclusion bodies, in Lipids oping intestine and, 104:916-srr gastric mucous cells (rat), 104:103 in cholecystitis (rabbit), 104:248 in duodenal bicarbonate transport (rab• Large intestine in gastric mucous cells (rat), 104:103 bit), 104:732 NSAID side effects in, 104:1832-srr in pancreatitis, 104:1527-cr, 104:1560-e transport, in human biliary cell lines, ventromedial hypothalamic lesions and 5-Lipoxygenase inhibitor 104:1796 DNA synthesis in (rat), 104:475 for acetic acid-induced colitis (rat), K+ channels, basolateral, in esophageal Laser photoablation, of Barrett's epithe• 104:1021 cells (rabbit), 104:417 lium, 104:1855-e, 104:1686 for chronic colitis (rat), 104:47 June 1993 SUBJECT INDEX 1925

Liquids, intragastric distribution of, ciga• endothclin 1 binding site in (rat), Lysosomal hydrolases, in acute pancre• rette smoking effects on, 104:410 104:1745 atitis, 104:1768 Liver hepatitis B virus mutations and, 104:263 Lysosomes, in M cells (rat), 104:698 bile duct epithelial cells and (rat), hepatitis C virus RNA in, 104:1472 104:840 hydatid cysts and, 104:1452 Mac-1, in Crohn's disease, 104:772 bile salt clearance and (rat), 104:165 injury Macromolecular permeability, gut, in cachectin/tumor necrosis factor and NSAIDs in, 104:569 pancreatitis (rat), 104:890 (rat), 104:235 propafenone in, 104:1524-cr Macromolecular uptakes, in intestine, cancer sulindac in, 104:569 104:622-srr combined modality treatment of, itch, etiology of, 104:1-tmig Macrophage-derived mucin secreta- 104:196 necrosis, activated macrophages in (rat), gogue, in inflammatory bowel in genetic hemochromatosis, 104:2- 104:1466 disease, 104:1302 tmig, 104:228 nodular transformation of, 104:616-cr, Macrophages hepatitis B virus and, 104:961 activated, in liver necrosis (rat), 104:759 orthotopic liver transplantation for, 104:1466 pruritis, propofol and, 104:244 104:317-e in acute pancreatitis (rat), 104:1498 regeneration, y-aminobutyric acid in cells, in hepatitis C virus infection, in colonic inflammation (rat), 104:759 (rat), 104:217 104:595 Magnetron, in endoscopy (dog), cirrhosis tauroursodeoxycholic acid effect on cy- 104:672-tmig, 104:680, 104:672 abdominal pressure and hemody• tosolic Ca2+ in (rat), 104:604 Major histocompatibility antigen namics in, 104:222 transplantation, 104:673-ceig (MHC)-restricted cytotoxicity, amino acid kinetics in, 104:1858-e, in combined modality treatment for in inflammatory bowel disease, 104:1712, 104:1886-c liver cancer, 104:196 104:384 cancer and, 104:2-tmig guide to, 104:1233-br Major histocompatibility complex Captopril and renal function in, hepatitis D recurrence after, 104:1122 (MHC) class II determinants, in 104:588 for hepatocellular carcinoma, M cells (rat), 104:698 central blood volume in, 104:1878-ss 104:317-e Malabsorption, in liver disease, cyclosporin A for, 104:519 orthotopic, 104:317-e, 104:1122 104:1587-tmig, 104:1727 cytokines and, 104:1248-tmig Liver/kidney microsome type 1 Mallory body-like material, in hepatitis endothelin in, 104:1485 in cryptogenic chronic active hepatitis, C virus infection, 104:595 first bleeding in, 104:1460 104:1588-tmig, 104:1755, 104:1756 Mannitol, intestinal permeability to, gastrointestinal hemorrhage and, in hepatitis C virus, 104:1762 104:1588-tmig, 104:1627 ' 104:1238-c in type II autoimmune hepatitis, Manometry glomerular filtration rate in, 104:884 104:1870-e deglutitive tongue action and, 104:152 with hepatitis B, 104:1 1 16 Loss of heterozygosity (LOH), p53 of sphincter of Oddi, I04:1243-c hyperdynamic circulation in, Massive foveolar hyperplasia and min• gene, in ulcerative colitis, 104:1633 104:l579-c imal inflammation, Menetrier's Lower esophageal sphincter (LES) interferon alpha for, 104:953-tmig disease and, 104:1310 central vagal efferent supply to (cat), interleukin 6 in, 104:1492 Mast cells 104:1430 kidneys in, 104:931-e, 104:1892-c activation of, prostaglandins in inhibi• inhibitory junction potentials of (opos• new strategies needed for treatment tion of (rat), 104:122 sum), 104:1439 of, 104:651-e ethanol-induced microvascular injury neural inhibition of (cat), 104:810 NSAID-induced renal dysfunction in, and (rabbit), 104:361 nitric oxide in relaxation of, 104:656-ss 104:869 prostanoids in release of inflammatory Luminal feedback regulation, of pan• peripheral arteriovenous shunting in, mediators from, I04:3l4-e 104:1139 creas (rat), 104:1780 Matrigel, in IGF-I receptor expression spontaneous bacteral peritonitis in, Lymphocytes (rat), 104:1705 104:954-tmig, 104:1 133 in acute pancreatitis (rat), 104:1498 Mauritius, a-chain disease in, 104:278-cr tumor necrosis factor a in, 104:1492 in celiac disease, 104:1263 M cells cyclosporin A and (rat), 104:1507 in colonic inflammation (rat), 104:759 endosomal-lysosomal system and la cytochrome P-450 in, 104:203 Lymphocytic gastritis, Menetrier's dis• expression in (rat), 104:698 disease ease and, 104:1310 macromolecular transport through, shock enhances translocation of gut Lymphoid follicles, in hepatitis C virus 104:622-srr bacteria in, 104:1587-tmig, infection, 104:595 McNeil-A343, in esophagitis (cat), 104:1722 Lynch syndromes I and II, hereditary 104:810 total parenteral nutrition and, nonpolyposis colorectal cancer Meal, smoking and intragastric distribu• 104:286-srr and, 104:1535-srr tion of, 104:410 viral hepatitis and, 104:944-br Lysine, biocytin and (rat), 104:75 Medetomidine, intestinal motility and vitamin E deficiency in, 104:1587- Lysolecithin, in cholecystitis (rabbit), (rat), 104:819 tmig, 104:1727 104:248 Medical education, changing, special iza- 1926 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

tion of gast roe nterology in Amer• Mexico, traveler's diarrhea in, 104:671- for sulindac-associated hepatic injury, ica and, 104:7-ceig tmig, 104:709 104:569 Melanoma, anorectal, 104:174 Microcirculation, leukocytes and, for ulcerative colitis, 104:1241-c Membrane stabilization, by ursodeoxy• 104:310-e Mosaic differentiation, of human villus cholic 104:1736 Microtiuorimetry, pH, regulation in enterocytes, 104:21 Membrane transport, in biliary cell lines, esophageal epithelial cells and Motilin 104:1796 (rabbit), 104:185 EM523 and (dog), 104:1320 Menetrier's disease, characterization of, Micronodular hyperplasia, peptic ulcer gallbladder motility and (dog), 104:1680 104:1310 disease and, 104:1356 pepsinogen and (guinea pig), 104:1030 Mental retardation, in agenesis of dorsal Motion sickness, vection-induced, relief Microorganisms, infectious, in Crohn's pancreas, 104:1183-cr disease, 104:351 of, 104:665-c Mepyramine, in Crohn's disease, Motoneuronal labeling, colonic vagus Microsomal Ca2+-translocase inhibitor, 104:1692 nerve and (rat), 104:502 tauroursodeoxycholic acid and Mercaptides, in ulcerative colitis, 104:802 MUC2 apomucin tandem repeat, detec• (rat), 104:604 Mercapto-fatty acid, in ulcerative colitis, tion of (mouse), 104:93 Microspectrofluorometry, taurourso• 104:802 Mucin deoxycholic acid effects on cyto- 6-Mercaptopurine, for ulcerative colitis, gallbladder, in cholesterol monohydrate solic Ca2+ in isolated hepatocytes 104:326-srr crystal growth, 104:1515 and (rat), 104:604 Mesalamine, for Crohn's disease, gastric 104:435, 104:1293 Microvascular injury, jejunal, ethanol-in- gastric acid and, 104:1878-ss Mesenteric circulation, nitric oxide in, duced (rabbit), 104:361 regulation of synthesis of, 104:1888-c 104:896 Microvillus membrane receptors, bac• Mucosal atrophy, cell kinetics of in Mesenteric venules, leukocyte adherence terial toxin binding to, 104:916-srr stomach (rat), 104:796 in (rat), 104:31 Microwave generator, in endoscopy Mucosal cells Messenger RNA (mRNA) (dog), 104:672-tmig, 104:680, hydrogen peroxide damage and (rat), cholecystokinin, 104:1092 104:926-e 104:780 a-fetoprotein, 104:256 Migrating myoelectric complexes prostaglandins in (rat), 104:103 gastrin, 104:1092, 104:1099 fedotozine and (rat), 104:724 Mucosal healing, transglutaminase and insulinlike growth factor, 104:1595 IL-lß action on intestinal motility and (rat), 104:65 insulinlike growth factor-binding pro• (rat), 104:377 Mucosal protection tein, 104:1595 Misoprostol, in mast cell activation (rat), epidermal growth factor in (rat), insulinlike growth factor 1, 104:973, 104:122 104:1605 prostanoids in, 104:314-e 104:1705 Missense mutations Multinucleation, liver cell, in hepatitis C interleukin 1, 104:749 in chronic hepatitis B virus infection, virus infection, 104:595 interleukin-2Rß, 104:448 104:263 Multiple endocrine neoplasia, carci• ileal proglucagon, 104:459 in ulcerative colitis, 104:1633 noids and, 104:994 trefoil peptide, 104:12 Mitomycin C, in experimental colitis Multivisceral transplantation, history of, Metallothionein, in Wilson's disease, (rat), 104:1049 104:675-ceigxlMuscarinic syn• 104:1566-ss MK-329, cholecystokinin and, 104:1414 apses, JO 1784 and (rat), 104:427 Metallothionein I promoter, bovine MK-886, for chronic colitis (rat), 104:47 growth hormone gene and (trans• MMS-68, in inflammatory bowel disease, Muscle contraction, in colitis (rat), genic mice), 104:973 104:1302 104:1049 Metaplasia, intestinal, esophageal cancer Mobilferrin, as calreticulin homologue Muscularis mucosae, colonic, in colitis and, 104:510 (rat), 104:1700 (rabbit), 104:369 [met]-enkephalin Mononitrates, for variceal bleeding, Muscular wasting, cachectin/tumor ne• gallbladder motility and (dog), 104:1680 104:1247-tmig, 104:1460 crosis factor and (rat), 104:235 in pyloric sphincter (rat), 104:1072 Mononuclear cells Mycobacteria, in Crohn's disease, 104:351 Methanogenic bacteria, in pneumatosis granulomalike aggregates of, in Crohn's Mycoplasma spp., in Crohn's disease, cystoides intestinalis, 104:392 disease, 104:772 104:351 Methotrexate (MTX) lamina propria Myeloperoxidase, in colonic inflamma• in inhibition of white cell stickiness, interleukin 1 in, 104:749 tion (rat), 104:759, 104:1021, 104:1 -tmig interleukin 2 in (rat), 104:964 104:1049 leukocyte adhesion and (rat), 104:31 Morphine Myenteric neurons, small intestinal, pre• for primary biliary cirrhosis, 104:652-e ileus and (rat), 104:724 synaptic inhibition by adenosine Methylene blue, in lower esophageal spinal, itching and, 104:1-tmig, 104:244 on (guinea pig), 104:1420 sphincter relaxation, 104:657-ss Mortality rates Myenteric plexus N'-Methylhistamine, elimination, from for acute pancreatitis, 104:1165 acetylcholine release and (rat), 104:1648 gastric mucosa (rabbit), 104:1013 for esophageal cancer, 104:1037 in chronic intestinal pseudo-obstruc• Metranidazole, for pouchitis, 104:981 for liver cancer, 104:196 tion, 104:1398 June 1993 SUBJECT INDEX 1927

Myotomy, on proximal duodenum (Aus• trefoil peptide expression and, lower esophageal sphincter and (opos• tralian possum), 104:130 104:12 sum), 104:1439 Mz-ChA-1 cells, membrane transport in, Neuroendocrine carcinomas, identifica• in pancreatic blood flow, 104:896 104:1796 tion of, 104:994 NG-nitro-L-arginine methyl ester, gas• Neuroendocrine function, calcitonin tric hyperemia mechanism and Na+ gene-related peptide in (rat), (rat), 104:114 bacterial toxin interaction with devel• 104:485 Nicotinic agonists, synaptic behavior in oping intestine and, 104:916-srr Neuronal markers, in pyloric sphincter myenteric neurons and (guinea biocytin and (rat), 104:75 (rat), 104:1072 pig), 104:1420 in cryptosporidiosis (pig), 104:440 Neurons Nitecapone, bicarbonate secretion and, EHEC 0157:H7 and (rabbit), 104:467 capsaicin-sensitive (rat), 104:1371 104:825, 104:1409 endothelin 1 and (rat), 104:1328 distension and (rat), 104:834 Nitrates + K channels and, 104:417 Neuropathy in colonic inflammation (rat), 104:759 low-dose Captopril and, 104:588 agenesis of dorsal pancreas and, for variceal bleeding, 104:1247-tmig, octreotide and (rat), 104:575 104:H83-cr 104:1460 pHj regulation in esophageal epithelial essential mixed cryoglobulinemia and, Nitric oxide cells and (rabbit), 104:185 104:273-cr calcitonin gene-related peptide and, in NADH-cytochrome c reductase, cy• gangliosides in prevention of (rat), capsaicin protection (rat), 104:1371 tochrome P-450 in plasma mem• 104:1072 in colonic inflammation (rat), 104:759 brane and, 104:203 vitamin E deficiency in, 104:1587-tmig, in experimental cirrhosis (rat), 104:1750 Na-free solutions, in duodenal bicarbon• 104:1727 gastric hyperemia mechanism and (rat), ate transport (rabbit), 104:732 Neuropeptide Y (NPY) 104:114 Naloxone calretinin and, 104:1381 in inhibitory innervation of colon, acupressure and, 104:665-c gallbladder motility and (dog), 104:1680 104:690 ileus and (rat), 104:724 in pyloric sphincter (rat), 104:1072 in jejunum (dog, human), 104:398 tor pruritis, 104:1-tmig Neurotensin, gallbladder motility and lower esophageal sphincter and, Naloxone-methiodide, ileus and (rat), (dog), 104:1680 104:656-ss, 104:1439 104:724 Neurotransmitters in pancreatic blood flow control, Nasogastric tube, removal of, early oral 104:672-tmig feeding following, 104:324-srr in intestinal muscle (dog, human), in pancreatic secretion (dog), 104:896 Nasopharynx, a-chain protein in, 104:398 Nitric oxide synthase, in infantile hy• 104:278-cr in isolated colon, 104:690 pertrophic pyloric stenosis, National Institutes of Health (NIH), in lower esophageal sphincter relax• 104:658-ss gastroenterology and, 104:10-ceig ation, 104:656-ss Nitrite, in colonic inflammation (rat), Nausea Neutropenia, chronic inflammatory 104:759 endorphins and, 104:665-c bowel disease and, 104:328-srr Nitrogen pregnancy-related, cutaneous electro- Neutrophils cachectin and (rat), 104:235 gastrogram and, 104:1569-ss in acute pancreatitis (rat), 104:1498 in duodenal bicarbonate transport (rab• Negative feedback regulation, of active adhesion of to endothelial cell mono• bit), 104:732 ileal bile acid transport (guinea layers, methotrexate effect on, pig, rat), 104:38 104:31 Nitroglycerin, apamin and, 104:690 Nciguan point, for motion sickness, in alopecia with ulcerative colitis, Nitroprusside, in lower esophageal 104:665-c 104:1 187-cr sphincter relaxation, 104:657-ss Neonates, scrum bile salt levels in, in colonic inflammation (rat), 104:759 Nodose ganglia, neural projections and 104:165 in inflammatory bowel disease (rat), (Australian possum), 104:130 Nerves 104:953-tmig, 104:1021 Nodular hyperplasia, of liver, 104:616-cr calcitonin gene-related peptide and omeprazole and, 104:938-ss Nonadrenergic, noncholinergic (rat), 104:485 New South Wales, peptic ulcer in, (NANC) nerves, of lower esoph• intermediate cells of Cajal and, 104:343 104:1083 ageal sphincter (opossum), lower esophageal sphincter and (opos• NG-monomethy 1-L-arginin e 104:1439 sum), 104:1439 jejunal nitric oxide and (dog, human), Nonadrenergic, noncholinergic Neural inhibition 104:398 (NANC) neurotransmitters in esophagitis (cat), 104:810 in pancreatic blood flow, 104:672-tmig in isolated colon, 104:690 in intestinal circular muscle, nitric ox• NG-nitro-L-arginine in lower esophageal sphincter relax• ide mediation of (dog, human), calcitonin gene-related peptide and ation, 104:656-ss 104:398 (rat), 104:1371 Non A, non B (NANB) hepatitis Neural projections, from duodenum to in inhibitory innervation of colon, discovery of, 104:958 biliary tract (Australian possum), 104:690 new virus in, l04:335-tmig, 104:556, 104:130 jejunal nitric oxide and (dog, human), 104:640-e Neuroendocrine cells, hyperplasia of, 104:398 in renal tranplant recipients, 104:862 1928 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Nonaspirin, nonsteroidal anti-inflam• Omeprazole Oxytocin, gallbladder motility and (dog), matory drugs, (NANSAIDs), for Barrett's esophagus, 104:1855-e, 104:1680 peptic ulcer and, 104:1083 104:1686 Nonsense mutations, p53 gene, in ulcer• fecal Helicobacter mustelae and (ferret), p53 oncogene ative colitis, 104:1633 104:86 in colorectal carcinoma, 104:2-tmig, Nonspecific esophageal motility dis• in gastric polyposis, 104:1584-c 104:57 order (NEMD), characterization neutrophil function and, 104:938-ss in ulcerative colitis, 104:1633, of, 104:1281 for peptic ulcer disease, 104:1356 104:1889-c Nonsteroidal anti-inflammatory drugs Oncogenes Pacific region, alcoholism in, 104:663-br (NSAIDs) colorectal carcinoma and, 1()4:2-tmig, Pancreas in appendicitis, 104:1571-ss 104:57 cancer, MLJC2 apomucin tandem repeat in hepatic injury, 104:569 immortalized colon cell lines and (rat), and (mouse), 104:93 renal dysfunction induced by, in cir• 104:1346 dorsal, 104:1182-cr rhosis, 104:869 Oncotic pressure, albumin and a-feto- duct obstruction in (opossum), 104:853 side effects of, 104:1832-srr protein regulation by, 104:256 exocrine sucrose permeability and, 104:1619 Opiate antagonist, for pruritis, 104:1- FK506 and (rat), 104:1153 Nor-binaltorphimine, ileus and (rat), tmig insufficiency of, 104:1255-ceig 104:724 Opiates, for diarrhea, 104:671-tmig luminal feedback regulation of (rat), Nordihydroguaiaretic acid (NDGA), Opie myth, pancreatitis and, l()4:927-e 104:1780 acetic acid-induced colitis and Opioid agonist, in reversal of ileus (rat), somatostatin inhibition of secretin in (rat), 104:1021 104:724 (rat), 104:1146 Norepinephrine, in cirrhosis, 104:1485 K-opioid receptors, fedotozine and (rat), ileal proglucagon gene expression and Norfloxacin, for spontaneous bacterial 104:724 (rat), 104:459 peritonitis, 104:954-tmig Opthalmoplegia, vitamin E deficiency nitric oxide in, l04:672-tmig, 104:896 North America, alcoholism in, 104:663- in, 104:1587-tmig Pancreas divisum, stenting of, 104:1226- br Oral rehydration solutions, rice glucose ss Northern blotting analysis polymers in (rat), 104:81 Pancreaticojejunostomy, longitudinal, albumin and, 104:256 Organ culture, human fetal stomach in, for intraluminal pancreatic candi• 104:492 0t-fetoprotein and, 104:256 diasis, 104:1532-cr Organelles, lipidic, in gastric mucous NPC 15669, in inhibition of neutrophil Pancreatitis cells (rat), 104:103 recruitment (rat), 104:953-tmig, acute Organizations, gastroenterological, de• 104:1021 cellular kinetics of (rat), 104:1498 velopment of, 104:9-ceig NS4 protein, in hepatitis C virus, 104:580 chloroquine in, 104:1768 Oropharyngeal propulsive chamber, Nucleating proteins, cholesterol, damage prevention vs. damage con• deglutitive tongue action and, 104:646-e trol in, 104:1216-e Nucleus of the solitary tract, colonic 104:152 acute necrotizing (opossum), 104:853 vagus nerve and (rat), 104:502 Osmolality acute relapsing, after endoscopic Nutrition rice glucose polymers in oral rehydra• sphincterotomy, 104:1814-cr cachectin/tumor necrosis factor and tion solutions and (rat), 104:81 in agenesis of dorsal pancreas, (rat), 104:235 total parenteral nutrition and (rat), 104:1183-cr colonocyte, 104:802 104:235 chronic, history of, 104:1255-ceig Ouabain, in duodenal bicarbonate trans• early electron-microscopic acinar cell Obesity, gallbladder emptying stimuli port (rabbit), 104:732 derangements in, I04:1236-c and, 104:1880-ss OV6 antigen, in BDEC lines (rat), gabexate mesilate in, 104:1165 OC.2 antigen, in BDEC lines (rat), 104:840 gestational hyperlipidemic, extracorpo• 104:840 Ovalbumin, celiac disease and, 104:1263 real lipid elimination for, OC.3 antigen, in BDEC lines (rat), Overweight, colorectal adenomas and, 104:1527-cr, 104:1560-e 104:840 104:137 gut permeability in (rat), 104:890 Octanoic acid breath test, carbon-la• OX6 monoclonal antibody, M cells and Opie myth and, 104:927-e beled, to measure gastric emptying (rat), 104:698 recurrent, intraluminal pancreatic can• of solids, 104:1640 OX19 monoclonal antibody, in acute Octreotide didiasis presenting as, 104:1532-cr distension and, 104:1248-tmig pancreatitis (rat), 104:1498 in systemic lupus erythematosus, for portal hypertension (rat), 104:575 Oxygen, arteriovenous shunting and, 104:61 3-cr rectal afferent inhibition by, 104:1390 104:1139 Papillary stenosis, acute relapsing pan• ODT-8 SS, gallbladder motility and (dog), Oxygen-dependent metabolic path• creatitis as complication of, 104:1680 ways, in duodenal bicarbonate 104:1814-cr (0-3 fatty acids transport (rabbit), 104:732 Paraventricular nucleus (PVN), corti- in bowel cancer, 104:1239-c Oxyntic cells, histamine elimination and cotropin-releasing factor in (rat), in enteral nutrition, 104:936-ss (rabbit), 104:1013 104:716 June 1993 SUBJECT INDEX 1929

Parietal cell gastrin receptor, cloning of Phenolphthalein, in diarrhea induction, Polidocanol, for coagulation of bleeding (dog), 104:1876-ss 104:1007 ulcers (dog), 104:680 D-Penicillamine, for primary biliary cir• Phentolamine, bicarbonate secretion and Poly amines rhosis, 104:651-e (rat), 104:825 gastric damage and (rat), 104:65 Pentasa. See Mesalamine Phenylalanine, turnover, in cirrhosis, in gastrointestinal tract, 104:1577-br Peplomycin, for esophageal cancer, 104:1712, 104:1858-e Polyethylene glycol (PEG), in pancre• 104:953-tmig, 104:1037 Phenylephrine, tauroursodeoxycholic atitis (rat), 104:890 Pepsinogen, secretion, motilin and acid and (rat), 104:604 Polymerase chain reaction (PCR) erythromycin in regulation of Phloretin, ethanol-induced microvascular familial adenomatous polyposis and, (guina pig), 104:1030 injury and (rabbit), 104:361 104:954-tmig, 104:989 Peptic ulcer disease Phorbol ester, pancreatic FK506 and hepatitis B virus and, 104:263, 104:549 immune system and, 104:1874-ss (rat), 104:1153 hepatitis C virus and, 104:272-cr, nonsteroidal anti-inflammatory drugs Phospholipids 104:549, 104:556 and hospitalization rates of, ethanol and (rat), 104:179 hepatitis E virus and, 104:556 104:1083 in gastric mucous cells (rat), 104:103 HLA class II genes and, 104:741 omeprazole for, 104:1356 gastric surfactant and, 104:179 K-ras mutations and, 104:57, 104:1044 Peptide histidine isoleucine (PHI), Phosphotyrosine antibodies, immortal• Polymers, in a-chain disease, 104:278-cr gallbladder motility and (dog), ized colon cell lines and (rat), Polyposis 104:1680 104:1346 gastric, omeprazole in, 104:1584-c Peptide YY Physiological buffer, pH[ regulation in juvenile atypical, 104:910-cr gallbladder motility and (dog), 104:1680 esophageal epithelial cells and Polysaccharide-free diet, for pneumato• ileal proglucagon gene expression and (rabbit), 104:185 sis cystoides intestinalis, 104:392 (rat), 104:459 Physiology, gastrointestinal, early Ameri• Portal hypertension phytohemagglutinin lectin exposure and can studies of, 104:6-ceig bacterial translocation in, 104:1587- (rat), 104:1669 Phytohemagglutinin lectin, in mucosal tmig, 104:1722 Peptidoglycan-polysaccharide (PG- growth (rat), 104:1669 in cirrhosis, 104:222 PS), in inflammation (rat), 104:759 Pigment stones, gallbladder motility and, in focal nodular hyperplasia of liver, Percutaneous drainage, for hepatic hy- 104:563 104:616-cr datosis, 104:1452 Piroxicam, endothelin 1 and (rat), isosorbide-5-mononitrate in, 104:1460 Peripheral blood mononuclear cells 104:1328 octreotide for (rat), 104:575 (PBMCs) Plasma membrane, hepatocyte, cy• Portal-systemic nephropathy, hepatic in hepatitis C virus, 104:580 tochrome P-450 in, 104:203 cirrhosis and, 104:931-e in inflammatory bowel disease, 104:384 Plasmid-encoding adhesion factors, Portal tracts, aggregates in, in hepatitis C Peritoneum, mast cells in (rat), 104:122 virus infection, 104:595 Peritonitis EI I HC 0157:117 and (rabbit), Portosystemic shunts, indocyanine green ileus induced by, fedotozine in reversal 104:467 as measure of, 104:884 of (rat), 104:724 Plastic, in culture medium, in IGF-1 re• Postcapillary venules, leukocyte adher• spontaneous bacterial, 104:954-tmig, ceptor expression (rat), 104:1705 104:1133 Platelet-activating factor (PAF) ence in (rat), 104:31 Permeability, intestinal in chronic colitis (rat), 104:47 Postoperative feeding, liquid vs. solid fuel, 104:324-srr in Crohn's disease, 104:1588-tmig, endothelin 1 and (rat), 104:1328 Potassium chloride 104:1627, 104:1848-e leukocyte-endothelial cell adhesive in• marker for, 104:1619 teractions and (rat), 104:31 in Crohn's disease, 104:1692 Peyer's patches, jejunal, M cells in (rat), prostaglandins and (rat), 104:122 gallbladder motility and, 104:563 104:698 Pneumatosis cystoides intestinalis, hy• muscle contraction in colitis and (rat), PF-5901, in mast cell activation (rat), drogen metabolism in, 104:392 104:1049 104:122 Pneumonia, in agenesis of dorsal pan• splanchic vascular hyporeactivity and pH creas, 104:1183-cr (rat), 104:1750 in acute pancreatitis, 104:1768 Point mutations, p53 gene, in ulcerative Potassium conductance, esophageal cell bile, gallstone calcification and, colitis, 104:1633 K+ channels and (rabbit), 104:417 I04:1885-c Policy and Position Statement Potential difference, in duodenal bicar• biocytin and (rat), 104:75 Credentialing, 104:1563 bonate transport (rabbit), 104:732 gastric, fecal Helicobacter mustelae and Gastroenterology board recertification: Pouchitis (ferret), 104:86 a mandate for continuing scholar• inflammatory infiltrate in, 104:981 intracellular, in esophageal epithelial ship, 104:1221 problem with, 104:1209-e cells (rabbit), 104:185 Hospital credentialing standards for Powell, Don. W., M.D., 104:1249 Pharyngeal chamber, deglutitive tongue physicians who perform endosco• Powell Tuck Index, for Crohn's disease, action and, 104:152 pies, 104:1563 104:1064 Phenanthroline, hydrogen peroxide Recertification in gastroenterology, Precapillary connections, arteriovenous damage and (rat), 104:780 104:1220 shunting and, 104:1139 1930 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Precore mutations, in chronic hepatitis B Prostanoids Radioscintigraphy, of nonspecific virus infection, 104:263 in acute cholecystitis (rabbit), 104:248 esophageal motility disorder, Prednisone in cryptosporidiosis (pig), 104:440 104:1281 for collagenous colitis, 104:906-cr in gastric mucous cells (rat), 104:103 Ranitidine, for peptic ulcer disease, for cryptogenic chronic active hepatitis, in inflammatory mediator release from 104:1356 104:1757 mast cells, 104:314-e ras oncogenes for primary biliary cirrhosis, 104:651-e Protamine, basic fibroblast growth factor in colorectal cancer, 104:2-tmig, Pregnancy and (frog), 104:1337 104:57, 104:1044 first trimester, gastric myoelectrical Protease, in inhibition of Toxin A intes• immortalized colon cell lines and (rat), activity, in, 104:1569-ss tinal effects (rat), 104:1108 104:1346 fulminant hepatitis in, 104:556 Protease inhibitor, in acute pancreatitis, Raynaud's syndrome, essential mixed gestational hyperlipidemic pancreatitis 104:1165 cryoglobulinemia and, 104:273-cr in, 104:1527-cr, 104:1560-e Protein, cachectin/tumor necrosis factor 86Rb, membrane transport and, 104:1796 intrahepatic cholestasis of, 104:660-ss and (rat), 104:235 Receptor-mediated transport capacity, Prelysosomes, in M cells (rat), 104:698 Protein cross-linking, gastric damage in a-chain disease, 104:278-cr Presynaptic inhibition, by adenosine and (rat), 104:65 Recertification, in gast roe nterology, (guinea pig), 104:1420 Prothrombin time 104:1220-paps, 104:1221-paps Primary biliary cirrhosis arteriovenous shunting and, 104:1139 Recombinant proteins, hepatitis C virus, cyclosporin A for, 104:519 in spontaneous bacterial peritonitis, 104:580 new strategies needed for treatment of, 104:954-tmig Rectal afferent inhibition, by octreotide, 104:651-e Proton pump inhibitor, in hypochlorhy- 104:1390 Primary sclerosing cholangitis, urso• dria (ferret), 104:86 Rectosigmoid neoplasia, in ulcerative deoxycholic acid for, 104:941-ss Proulcerogenic mediators, in mast cells colitis, 104:666-c Proctocolectomy, anal transition zone (rat), 104:122 Rectum and, 104:514 pS2 peptide, gene expression, in gastro• anal transition zone and, 104:514 Progastrin, in colorectal carcinoma, intestinal epithelial cells in inflam• colonic vagus nerve and (rat), 104:502 104:1099 matory bowel disease, 104:12 Red blood cell membranes, ursodeoxy- Proglucagon gene, ileal, expression of Pseudo-obstruction, chronic intestinal, cholate in stabilization of, 104:1736 (rat), 104:459 in infants and children, 104:1398 Red kidney bean phytohemagglutinin Propafenone, hepatotoxicity of, Psyllium, for secretory diarrhea, 104:1007 lectin, in mucosal growth (rat), 104:1524-cr Puerto Rico, alcoholism in, 104:663-br 104:1669 Propofol, for pruritis, 104:1 -tmig, 104:244 Pulmonary arterial hypertension, focal Reducing agents, colonocyte nutrition Propranolol, for variceal bleeding, nodular hyperplasia of liver and, and, 104:802 104:1247-tmig, 104:1460 I04:616-cr Reducing sulfur compounds, in ulcera• Prostacyclin,endothelin 1 and (rat), Purine analogues, for ulcerative colitis, tive colitis, 104:802 104:1328 104:325-srr Regulatory peptides, intestinal growth

Prostaglandin E2 (PGE2) Purine nucleoside Phosphorylase, sinu• and, 104:1205-e coli tic muscularis mucosae and (rabbit), soidal endothelial cell damage and Regulatory volume decrease, K+ chan• 104:369 (rat), 104:1466 nels and, 104:417 in cryptosporidiosis (pig), 104:440 Purpura, essential mixed cryoglobulin• Renal duplication, in agenesis of dorsal in duodenal bicarbonate secretion, emia and, 104:273-cr pancreas, 104:1183-cr 104:732, 104:1409 Putrescine Renin interleukin 2 and (rat), 104:964 y-aminobutyric acid in liver regenera• arteriovenous shunting and, 104:1139 in mast cell activation (rat), 104:122 tion and (rat), 104:217 in cirrhosis, 104:1485 pepsinogen and (guinea pig), 104:1030 transglutaminase and (rat), 104:65 octreotide and (rat), 104:575 Prostaglandin F2a (PGE2), colitic mus• Pyloric sphincter, neuropathy in, pre• Restraint-stress, 4-hour, ulcers and (rat), cularis mucosae and (rabbit), vention of (rat), 104:1072 104:427 104:369 Pyloric stenosis, infantile hypertrophic, Restriction enzyme digestion, Ki-ras Prostaglandin I2 (PGI2), in cholecystitis nitric oxide synthase in, 104:658-ss codon 12 mutations and, 104:57 (rabbit), 104:248 Pyrilamine, gastric hyperemia mecha• Retrograde intragastric movement, cig• Prostaglandins nism and (rat), 104:114 arette smoking and, 104:410 calcitonin gene-related peptide and Pyrogallol, in lower esophageal sphincter Reverse transcription, of HCV RNA, (rat), 104:1371 relaxation, 104:657-ss 104:877 gastric hyperemia mechanism and (rat), Review process, for GASTROENTEROL• 104:114 Quinine, esophageal cell K+ channels and OGY, 104:1252-e in gastric mucous cells (rat), 104:103 (rabbit), 104:417 IL-lß action on intestinal motility and Rice glucose polymers, in oral rehydra• (rat), 104:377 Race tion solutions (rat), 104:81 indomethacin and, 104:869 anorectal melanoma and, 104:174 Right-sided tumors, in colorectal carci• in inhibition of mast cell activation colorectal adenomas and, 104:1445 noma, 104:57 (rat), 104:122 Radiography,in Crohn's disease, 104:351 rlRAP, for chronic colitis (rat), 104:47 June 1993 SUBJECT INDEX 1931

RNA Leiomyosarcoma: not all gastric malig• Sigmoidoscopy, of inflammatory infil• in enteral nutrition, 104:936-ss nancies have a dismal prognosis, trate in pouchitis, 104:981 hepatitis C virus, i()4:671-tmig, 104:940 Signal transduction 104:862, 104:877, 104:1472 Molecular genetics and colorectal bacterial toxin binding and, 104:916-srr RP55778, for chronic colitis (rat), 104:47 cancer, 104:1223 epithelial, Salmonella typhimurium and, More problems with aspirin: it may- 104:326-srr Saccharomyces boulardii, in inhibition of cause appendicitis, 104:1571 Silencing, peripheral clonal, in graft ac• Toxin A intestinal effects (rat), Nausea and vomiting of pregnancy and ceptance, 104:678-ceig 104:1108 cutaneous electrogastrogram, Simian virus 40 (SV40) LT gene, im• Saline 104:1569 mortalized colon cell lines and intragastric hypertonic, in gastric hy• Nitric oxide is (or is not) everywhere!, (rat), 104:1346 peremia (rat), 104:114 104:658 Sinusoidal endothelial cells, damage to, isotonic, y-aminobutyric acid in liver Noninvasive sphincter of Oddi testing: by activated macrophages in liver regeneration and (rat), 104:217 what's the score?, 104:654 necrosis (rat), 104:1466 Salmonella typhimurium, epithelial sig• Odd forms of inflammatory bowel dis• Sinusoidal inflammatory cells, in hepa• nal transduction mechanisms for ease: what can they tell us?, 104:327 titis C virus infection, 104:595 invasion and, l()4:326-srr Omeprazole and neutrophil function, Sk-ChA-1 cells, membrane transport in, Sarcoidosis, intestinal involvement in, 104:938 104:1796 104:947-c Pancreas divisum: to stent or not to SKF-38393, bicarbonate secretion and SC 19220, IL-lß action on intestinal mo• stent, 104:1226 (rat), 104:825 tility and (rat), 104:377 Postoperative feeding: liquid versus Small-droplet fat, in hepatitis C virus in• Scleroderma, nonspecific esophageal mo• solid fuel, 104:324 fection, 104:595 tility disorder and, 104:1281 A potential role for the immune system Small intestine Scopolamine, pancreatic FK506 and in gastric acid secretion and peptic in Crohn's disease, 104:1692 (rat), 104:1 153 ulcer disease, 104:1874 cytochrome P450 in (rat), 104:1611 Secretin Predicting recurrence in colorectal growth hormone and (transgenic mice), gallbladder motility and (dog), 104:1680 cancer patients, 104:1225 104:973 pepsinogen and (guinea pig), 104:1030 Promises, promises: ursodeoxycholic interstitial cells of Cajal in, 104:343 somatostatin and, 104:1146, 104:1414 acid for primary sclerosing cho• ischemia of, Buerger's disease present• Secretory diarrhea, treatment of, langitis, 104:941 ing as, 104:1192-cr 104:1007 Purine analogues and ulcerative colitis, mosaicism of brush border antigens in, Secretory protein, gene expression, in 104:325 104:21 gastrointestinal epithelial cells in A redoubtable obstacle to a hepatitis C MUC2 apomucin tandem repeat and inflammatory bowel disease, 104:12 vaccine, 104:1228 (mouse), 104:93 Selected Summaries The silent epidemic of hepatitis C, myenteric neurons, adenosine A, recep• Adhesion molecule expression in in• 104:661 tors and (guinea pig), 104:1420 flammatory bowel disease, 10 g of fat per day may keep gallstones NSATD side effects in, 104:1832-srr 104:1568 away, 104:1880 permeability of, 104:1627 Appendectomy — will the laparoscope Ursodeoxycholic acid treatment of in• phytohemagglutinin lectin and (rat), reign?, 104:935 trahepatic cholestasis of pregnancy: 104:1669 Central blood volume in cirrhosis, observations on efficacy and safety, pseudo-obstruction and, 104:1398 104:1878 104:660 resection Does the gallbladder secrete?, 104:329 Zinc in the treatment of Wilson's dis• cholesterol and bile acid biodynamics An enteric pathogen subverts epithelial ease: how it works, 104:1566 after, 104:1786 signal transduction mechanisms Semisolid emptying, in nonspecific terminal ileum adaptive response to for invasion, 104:326 esophageal motility disorder, (rat), 104:459 Food allergy: fact, fiction, and fatality, 104:1281 rice glucose polymers in oral rehydra• 104:1229 Septicemia, cytokines in, 104:1492 tion solutions and (rat), 104:81 The gastrin (or is it CCK-B?) receptor Seroconversion, hepatitis A virus and, trefoil peptide expression in, 104:12 on the parietal cell is cloned, 104:1129 ventromedial hypothalamic lesions and 104:1876 Shanghai, alcoholism in, 104:664-br DNA synthesis in (rat), 104:475 Helicobacter pylori and duodenal ulcer Shock, in translocation of gut bacteria, Smith's silver technique, myenteric disease: the somatostatin link?, 104:1587-tmig, 104:1722 plexus and, 104:1398 104:1573 Short bowel syndrome, diarrhea in, SMS-201-995, secretin action and (rat), 1low gastric acid may get to he there, 104:671-tmig 104:1146 104:1878 Short-circuit current Sodium chloride (NaCl) Immunonutrition?, 104:936 in duodenal bicarbonate transport (rab• in cryptosporidiosis (pig), 104:440 Is nitric oxide the noncholinergic, non• bit), 104:732 gastric mucosal injury induced by, adrenergic neurotransmitter re• K+ channels and, 104:417 transglutaminase effect on (rat), sponsible for lower esophageal (5 ligand, cysteamine duodenal ulcers and 104:65 sphincter relaxation?, 104:656 (rat)! 104:427 retention, in cirrhosis, 104:1139 1932 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

Sodium hydrogen sulfide, in ulcerative Starch hydrolysates, rice, in oral rehy• Superoxide colitis, 104:802 dration solutions (rat), 104:81 hydrogen peroxide damage and (rat), Sodium mercaptoacetate, in ulcerative Steatohepatitis, total parenteral nutrition 104:780 colitis, 104:802 and, 104:286-srr omeprazole and, 104:938-ss Solids, intragastric distribution of, ciga• Steatosis, total parenteral nutrition and, Superoxide dismutase, hydrogen perox• rette smoking effects on, 104:410 104:286-srr ide damage and (rat), 104:780 Somatostatin Stem cells, mosaicism of brush border Suramin, basic fibroblast growth factor analogue, rectal afferent inhibition by, antigens and, 104:21 and (frog), 104:1337 104:1390 Stenting, for pancreas divisum, Survival rates capsaicin-induced neuroendocrine re• 104:1226-ss for esophageal cancer, 104:1037 sponses and (rat), 104:485 Sterols, biodynamics of, after total enter• for leiomyosarcoma, 104:940-ss cholecystokinin and, 104:1414 ectomy, 104:1786 for liver cancer, 104:196 distension and (rat), 104:834 Stomach Swallow function duodenal ulcers and, 104:1573-ss cell kinetics of mucosal atrophy in (rat), brainstem and (cat), 104:1430 gallbladder motility and (dog), 104:1680 104:796 deglutitive tongue action and, 104:152 Helicobacter pylori gastritis and, 104:1573- cigarette smoking and, 104:410 Sympathetic nervous activity, central ss colonic vagus nerve and (rat), 104:502 blood volume in cirrhosis and, irritable bowel syndrome and, distension, gastric secretion induced by 104:1878-ss 104:1248-tmig (rat), 104:834 Synthase inhibitors, jejunal nitric oxide kidney function in cirrhosis and, EM523 and (dog), 104:1320 and (dog, human), 104:398 104:1892-c human fetal, in organ culture, 104:492 Systemic lupus erythematosus, chronic secretin and, 104:1146, 104:1414 hydrophobic surface properties of (rat), pancreatitis in, 104:613-cr Spain, spontaneous bacterial peritonitis 104:103 Systemic vascular resistance, arteriove• in, 104:954-tmig leiomyosarcoma of, 104:940-ss nous shunting and, 104:1139 Specialization, of gastroenterology in MUC2 apomucin tandem repeat and America, 104:6-ceig (mouse), 104:93 Tachygastria, acupressure and, 104:665-c Special Reports and Reviews peptic ulcer disease and, 104:1356 Bacterial toxin interaction with the de• prostaglandins in (rat), 104:103 Taiwan, alcoholism in, 104:664-br veloping intestine, 104:916 pseudo-obstruction and, 104:1398 Taurine, bile acids conjugated with, in Genetics, natural history, tumor spec• ventromedial hypothalamic lesions and cholecystitis (rabbit), 104:248 trum, and pathology of hereditary DNA synthesis in (rat), 104:475 Taurocholate nonpolyposis colorectal cancer: an Stool culture, selective, in Crohn's dis• cyclosporin A and (rat), 104:1507 updated overview, 104:1535 ease, 104:351 passive absorption of (rat), 104:165 Hepatobiliary complications of total Streptozotocin, in diabetes induction ulcers and (rat), 104:427 parenteral nutrition, 104:286 (rat), 104:1072 Taurolithocholic acid, tauroursodeoxy- Side effects of nonsteroidal anti-inflam• Stress, in colonic transit acceleration (rat), cholic acid and (rat), 104:604 matory drugs on the small and 104:716 Tauroursodeoxycholic acid (TUDCA), large intestine in humans, 104:1832 Strontium, gallbladder motility and, effects of on cytosolic Ca2f in iso• Uptake and transport of macromole- 104:563 lated hepatocytes (rat), 104:604 cules by the intestine: possible role Submucosal ganglionic plexus neu• T cell activation genes, in inflammatory in clinical disorders (an update), rons, differing chemical content bowel disease, 104:448 104:622 of, 104:1579-c T cells Sphincter of Oddi Substance P in hepatitis C virus, 104:580 group I patients and, 104:1243-c calretinin and, 104:1381 in inflammatory bowel disease, nerve cell projections and (Australian colitic muscularis mucosae and (rabbit), 104:335-tmig, 104:384, 104:448 possum), 104:130 104:369 noninvasive testing of, 104:654-ss Temperature, biocytin and (rat), 104:75 muscle contraction in colitis and (rat), Spina bifida, in agenesis of dorsal pan• 12-O-Tetradecanoy lphorbol 13-acetate 104:1049 creas, 104:1183-cr FK506 and (rat), 104:1153 in pyloric sphincter (rat), 104:1072 Spinal cord somatostatin action on (rat), 104:1146 Sucrose, as permeability marker, 104:1619 colonic vagus nerve and (rat), 104:502 Tetrodotoxin morphine injection into, pruritis and, Sucrose octasulfate, basic fibroblast capsaicin-induced neuroendocrine re• 104:1-tmig, 244 growth factor and (frog), 104:1337 sponses and (rat), 104:485 Splanchic vascular hyporeactivity, in Sulfasalazine distension and (rat), 104:834 cirrhosis, nitric oxide in (rat), for acetic acid-induced colitis (rat), endothelin 1 and (rat), 104:1328 104:1750 104:1021 JO 1784 and (rat), 104:427 Spontaneous bacterial peritonitis, in for collagenous colitis, 104:906-cr nitric oxide and, 104:690 cirrhotics, 104:954-tmig, 104:1133 Sulfate-reducing bacteria, in pneumato• Thapsigargin, membrane transport and, Squamous re-epithelialization, in sis cystoides intestinalis, 104:392 104:1796 Barrett's esophagus, 104:1855-e, Sulfur, in ulcerative colitis, 104:802 Theophylline, in duodenal bicarbonate 104:1686 Sulindac, in hepatic injury, 104:569 transport (rabbit), 104:732 June 1993 SUBJECT INDEX 1933

This Month in GASTROENTEROLOGY Threonine, MUC2 apomucin tandem liver Apo E and gallstones: a genetic link?, repeat and (mouse), 104:93 in combined modality treatment for 104:1587 Thromboangitis obliterans, with isch• liver cancer, 104:196 Are T cells the culprit in IBD?, 104:335 emia of small bowel, 104:1192-cr guide to, 104:1233-br A blood test for familial adenomatous Thromboxane A2, in chronic colitis hepatitis D recurrence after, 104:1122 polyposis, 104:954 (rat), 104:47 for hepatocellular carcinoma, Cutting the neutrophil off at the pass, Thromboxanes, in experimental colitis, 104:317-e 104:953 104:1891-c orthotopic, 104:317-e, 104:1122 Cytokines predict mortality in infected Thymidine labeling Transverse colon, colonic vagus nerve cirrhotics, 104:1248 y-aminobutyric acid in liver regenera• and (rat), 104:502 Death and resurrection of the perme• tion and (rat), 104:217 Trauma, bacterial translocation in, ability hypothesis, 104:1588 human fetal stomach in organ culture 104:1587-tmig EHEC: a nasty bug even without vero- and, 104:492 Traveler's diarrhea, zaldiride maleate for, toxin, 104:336 Thyrotropin-releasing hormone 104:671-tmig, 104:709 Endothelin: a peptide in search of a (TRH), gallbladder motility and Trefoil peptide, gene expression, in gas• disease, 104:1247 (dog), 104:1678 trointestinal epithelial cells in in• Fulminant NANB hepatitis: is a new T lymphocytes flammatory bowel disease, 104:12 virus involved?, 104:335 in acute pancreatitis (rat), 104:1498 Trichinella spiralis GASTROENTEROLOGY celebrates its M cells and (rat), 104:698 acetylcholine release and (rat), 104:1648 golden anniversary, 104:1 TNM classification, for liver cancer, in experimental colitis (rat), 104:1049 Genes and IBD: the DR and DQ con• 104:196 Triglycerides nection, 104:671 Tocopherol polyethylene glycol succi• ethanol and (rat), 104:179 Getting to the core of hepatitis C, nate (TPGS), in liver disease, in pancreatitis, 104:1527-cr, 104:1560-e 104:336 104:1587-tmig, 104:1727 Trinitrobenzene sulfonic acid (TNBS), Hemochromatosis and liver cancer: iron Tongue functions, deglutitive, 104:152 in colitis, 104:47, 104:369, may not be the whole answer, 104:2 Torovirus, in Crohn's disease, 104:351 104:964, 104:1049 Interferon for hepatitis B and cirrhosis, Total parenteral nutrition Triphosphopyridine nucleotide, hepa• 104:953 cachectin/tumor necrosis factor effects tobiliary complications of, Is cryptogenic chronic active hepatitis a and (rat), 104:235 104:1583-c form of autoimmune hepatitis?, hepatobiliary complications of, Trypsin, luminal feedback regulation of 104:1588 104:286-srr pancreas and (rat), 104:1780 Methotrexate unsticks the leukocyte, Total peripheral resistance, octreotide Trypsinogen, in pancreatitis, 104:890, 104:1 effect on (rat), 104:575 104:1768 A molecular basis for Duke's classifica• Toxigenic diarrhea of infancy, altered Tumor necrosis factor (TNF) tion?, 104:2 host sensitivity in, 104:916-srr in predicting mortality in infected cir• More on duodenal bicarbonate, Transaminase, in hepatitis C virus infec• rhotics, 104:1248-tmig 104:1247 tion, 104:862 prostaglandins and (rat), 104:122 New anesthetic agent knocks out pruri- Transcutaneous electrical nerve stimu• sinusoidal endothelial cell damage and tis, but not the patient, 104:1 lation, for pain relief, 104:665-c (rat), 104:1466 A new drug for traveler's diarrhea, Transendoscopic injection chemother• total parenteral nutrition and (rat), 104:671 apy, for esophageal cancer, 104:235 The new wave in endoscopy, 104:672 104:953-tmig Tumor necrosis factor a (TNF-a), in Nitrates prevent variceal bleeding, Transforming growth factor a (TGF-a), cirrhosis, 104:1492 104:1247 immunohistochemical localization A novel form of endoscopic therapy, of in colon (rat), 104:789 U-50 K agonist, in reversal of ileus (rat), 104:953 Transfusions, blood, liver cancer and, 104:724 Predicting SBP in cirrhotics, 104:954 104:2-tmig Ulceration, gastric, mast cells in, 104:122 Transglutaminase, gastric damage and Ulceration-associated cell lineage Shock enhances translocation of gut (rat), 104:65 (UACL) glands, trefoil peptide bacteria in liver disease, 104:1587 Transitional epithelium, of anal transi• expression in, 104:12 A short history of endoscopy, 104:335 tion zone, 104:514 Ulcerative colitis Slow-release 5-ASA for active Crohn's Translocase, tauroursodeoxycholic acid alopecia and, 104:1187-cr disease, 104:1247 and (rat), 104:604 anal transition zone in, 104:514 Somatostatin strikes again, 104:1248 Translocation, bacterial, 104:1587-tmig, azathioprine for, 104:325-srr A treatable neurological condition in 104:1722 high risk and low mortality in, patients with liver disease, Transplantation 104:1241-c 104:1587 bone marrow, for hepatitis B, HLA class II genes in, 104:741 What can we learn from HCV RNA?, 104:1818-cr interleukin 1 in, 104:749 104:671 of gastrointestinal organs, 104:673-ceig interleukin 2 in, 104:448 What controls pancreatic blood flow? kidney, hepatitic C virus infection and, interleukin 6 in, 104:1285 The answer is NO, 104:672 104:671-tmig, 104:862 MHC-restricted cytotoxicity in, 104:384 1934 SUBJECT INDEX GASTROENTEROLOGY Vol. 104, No. 6

p53 gene in, 104:1633, 104:1889-c Vagal afferent fibers, JO 1784 and (rat), Villous enterocytes, mosaic differentia• rectosigmoid neoplasia in, 104:666-c 104:427 tion of, 104:21 reducing sulfur compounds in, 104:802 Vagus nerve VIP[10-28], distension and (rat), 104:834 Ulcers colonic, central organization of (rat), Viral gastroenteritis, diarrhea in, basic fibroblast growth factor and 104:502 104:671-tmig (frog), 104:1337 gastrointestinal DNA synthesis through Viruses, in Crohn's disease, 104:351 JO 1784 for (rat), 104:427 (rat), 104:475 Vitamin E, deficiency, in liver disease, microwave endoscopy for (dog), Variceal bleeding, nitrates for, 104:1587-tmig, 104:1727 104:672-tmig, 104:680, 104:926-e 104:1247-tmig, 104:1460 Volume accomodation, deglutitive Ultrasonography Vasculitis, cryoglobulinemia with, tongue action and, 104:152 abdominal, of dorsal pancreatic agene• 104:272-cr Vomiting sis, 104:1182-cr Vasoactive intestinal polypeptide (VIP) pregnancy-related, cutaneous electro- in endoscopy, 104:926-e calbindin-D28K and, 104:1381 gastrogram and, 104:1569-ss of hydatid cysts, 104:1452 calretinin and, 104:1381 unexplained, 19-year-old woman with, United Kingdom, familial adenomatous in colitic muscularis mucosae (rabbit), 104:302-cch, 104:302 polyposis in, 104:954-tmig 104:369 v-src oncogene, immortalized colon cell United States distension and (rat), 104:834 lines and (rat), 104:1346 anorectal melanoma in, 104:174 in duodenal bicarbonate transport (rab• digestive diseases as national health bit), 104:732 problem in, 104:10-ceig FK506 and (rat), 104:1153 Water-holding agents, for treatment of familial adenomatous polyposis in, gallbladder motility and (dog), 104:1680 diarrhea, 104:1007 104:954-tmig, 104:989 in lower esophageal sphincter relax• Weight loss, cachectin/tumor necrosis HCV RNA levels after renal transplants ation, 104:657-ss factor and (rat), 104:235 in. 104:671-tmig pepsinogen and (guinea pig), 104:1030 Western blot analysis, cytochrome P450 specialization of gastroenterology in, in pyloric sphincter (rat), 104:1072 and (rat), 104:1611 104:6-ceig somatostatin and (rat), 104:1146 Western cultures, alcoholism in, vitamin E deficiency in, 104:1727 Vasodilation, peripheral, octreotide in 104:664-br Upper gastrointestinal bleeding, in the amelioration of (rat), 104:575 Wheat bran, for secretory diarrhea, critically ill, 104:1885-c Vasodilatory syndrome, in liver disease- 104:1007 Urea, bacterial production of ammonia by associated portal hypertension, Wilson's disease, zinc for, 104:1566-ss in stomach (rat), 104:796 104:575 Worldwide developments, in specializa• Ursodeoxycholate, membrane stabiliza• Vasopressin, gallbladder motility and tion of gastroenterology, 104:7-ceig tion by, 104:1736 (dog), 104:1680 Ursodeoxycholic acid Ventricular septal defect, in agenesis of Xanthine oxidase, hydrogen peroxide hepatoprotective properties of, dorsal pancreas, 104:1183-cr damage and (rat), 104:780 104:1865-e Ventromedial hypothalamic lesions, in for intrahepatic cholestasis of preg• gastrointestinal cell proliferation Yeast, in inhibition of Toxin A intestinal nancy, 104:660-ss (rat), 104:475 effects (rat), 104:1108 for primary biliary cirrhosis, 104:651-e Verapamil, endothelin 1 and (rat), Yersinia spp., in Crohn's disease, 104:351 for primary sclerosing cholangitis, 104:1328 104:941-ss Verotoxin, EH EC 0157:H7 and, Ursodeoxycholyltaurine, ileal entero- 104:336-tmig, 104:467 Zaldiride maleate, for traveler's diarrhea, cytes in active transport of (guinea Vibrio cholerae, in traveler's diarrhea, 104:671-tmig, 104:709 pig, rat), 104:38 104:671-tmig Zinc, for Wilson's disease, 104:1566-ss Viewpoints on Digestive Diseases Zollinger-Ellison syndrome, carcinoids What are functional bowel disorders? and, 104:994 Vaccines 104:1196 Zymogens for hepatitis A virus, 104:1129, Villous absorptive surface, in crypto• cytoplasmic, pancreatic FK506 and 104:1214-e sporidiosis (pig), 104:440 (rat), 104:1153 for hepatitis C virus, 104:1228-ss Villous atrophy, subtotal, in celiac dis• digestive enzyme, in acute pancreatitis, for hepatitis viruses, 104:962 ease, 104:1263 104:1768 1878 SELECTED SUMMARIES GASTROENTEROLOGY Vol. 104, No. 6

CENTRAL BLOOD VOLUME IN CIRRHOSIS

Henriksen J, Bendtsen F, Gerbes A} et al. (Departments of Clini• cal Physiology and Hepatology, Hvidovre Hospital, Univer• sity of Copenhagen, Copenhagen, Denmark; Department of Internal Medicine and Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; and De• partment of Medicine II Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany). Estimated cen• tral blood volume in cirrhosis: relationship to sympathetic nervous activity, ß-adrenergic blockade and atrial natri• uretic factor. Hepatology 1992;16:1163-1170.

The dispute between the "overflow" and "underfill" the• ories of early pathophysiology in cirrhosis shows no signs of early resolution. Regardless of what the initial events might be, however, in the more advanced stages of cirrhosis the clinical picture suggests a maldistribution of blood volume. The authors of the present article have been interested in determining the volume of blood contained in the heart, lungs, and central arterial tree, which they have termed the estimated central blood volume (ECBV). The present study from Copenhagen is an attempt to quantify the ECBV and June 1993 SELECTED SUMMARIES 1879

to look for correlations with sympathetic nervous activity, 939-992) and (N Engl J Med 1982;309:1152-1 157). The authors atrial natriuretic factor (ANF) levels and the effects of contend that this central underfilling contributes directly to the adrenergic blockade on these parameters. This is one of a enhanced sympathetic activity with renal sympathetic overactivity series of studies by a group of investigators that has had a causing reduced renal blood flow and increased sodium and water retention in established cirrhosis. This interpretation is in keeping long-term interest in the hemodynamic abnormalities asso• with the authors' previous work in which an hypothesis is sug• ciated with cirrhosis. gested for the early changes in cirrhosis. They have postulated an Nineteen patients (17 male) with biopsy-proven cirrhosis initial decrease in peripheral resistance (of unknown cause), which were studied and compared with 16 subjects (12 male) with then leads to peripheral sequestration of fluid, a decrease in ECBF, normal hepatic function. Nine other subjects served as con• under perfusion of baro- and volume receptors with consequent trols for assay of arterial and renal venous catecholamines. increase in sympathetic activity and associated salt and water re• The cirrhotic patients were roughly equally divided into tention. Although this is an attractive theory, there are a number Child-Turcotte groups A-B and C. Patients and controls of factors it does not explain such as the role of other salt-retaining underwent catheterization of the right atrium as well as the hormones and the surprising lack of effect of ß-blockade on the hepatic and renal veins. An arterial catheter was positioned ECBV in spite of major hemodynamic shifts. This might raise the question of how definite an entity the ECBV is because its determi• at the bifurcation of the aorta. Total plasma volume, whole nation is based on catheter placement, which must be somewhat blood volume, and cardiac output were determined as previ• arbitrary. Rector (Gastroenterology 1988;95:1658-1663) reported ously described (Gastroenterology 1989;97:1506-1513) by that left atrial size was actually greater in cirrhotics, whereas both the same group of investigators. The hepatic gradient was left and right atrial pressures were similar in cirrhotics with and determined by direct measurement. without ascites. This would appear to excuse the heart of any "cen• The ECBV is calculated by multiplying the cardiac output tral underfilling" in cirrhosis. Because there is no evidence of dif• by the mean indicator transit time. The latter figure is the ferences in pulmonary vascular capacity, this leaves only the aorta mean time of indicator sojourn in the central vascular bed. as a possible site for the decreased ECBV. One could also point out This is estimated from the time-weighted area under the that there is no present explanation for the initial decrease in pe• arterial indicator curve following an injection of ^-la• ripheral resistance postulated by the authors, but this, perhaps, is not too different from the situation with the classic "overflow" belled albumin at the junction of the inferior vena cava and theory in which the early message from the liver to the kidney the right atrium with arterial sampling at the level of the remains a postulate rather than a measurement. aortic bifurcation. Plasma catecholamines and ANF levels The lack of any demonstrable role for the ANF in this theory is were determined by standard methods (Gut 1984;25:1034- surprising. ANF has been reported to be low, normal, and high in 1043; Liver 1986;6:361-368). cirrhosis. Unless these discrepancies are all due to technical errors There was a significant difference in the ECBV between (unlikely), this suggests that ANF levels may fluctuate at various cirrhotics (22.9 mL/kg) and controls (27.2 m.L/kg). As stages of cirrhosis, and our separation into "compensated" and would be expected from this finding, the mean central cir• "decompensated" is too crude to detect these changes. A recent culation time was less in the cirrhotic patients (14.0 sec• study by Angeli et al. (ITepatology 1992; 16:1 389-1394) has shown onds ±4.1) compared with the controls (20.0 seconds ± several subgroups of cirrhotics in which ANF levels correlate with 6.1). There was an inverse relationship between the hepatic various hormone patterns. The present study shows convincingly gradient, which reflects portal pressure, and the ECBV. The that plasma- and blood-volume distribution in cirrhosis is abnor• cirrhotics had an increase in total plasma volume along with mal. Most physicians will have little argument with the findings showing that cirrhotics have a high cardiac output, low peripheral a decrease in mean arterial blood pressure and systemic vas• resistance, and too much blood in the peripheral vessels and cular resistance. Arterial plasma norepinephrine (but not splanchnic bed with too little in the large central arteries, because epinephrine) levels were significantly increased in the pa• al! these determinations fit well w'th clinical observation. tients (3.08 vs. 1.36 nmol/L). There was an inverse correla• Whether increased sympathetic tone is an etiological factor in tion between norepinephrine levels and ECBV. Plasma these changes, however, remains at best an hypothesis. ANF levels were normal in both patients and controls, ß- J. G. SWEETING, M.D. blockade caused the expected decrease in heart rate and car• diac output while the central circulation time increased, thereby leaving the ECBV unchanged. Arterial catechol• Reply. We would like to thank Dr. Sweeting for his comments amines rose after propranolol administration, but there was on our report regarding central blood volume and sympathetic no correlation with the ECBV. overactivity in cirrhosis (Hepatology 1992;16:1163-1170). We fully agree that the dispute between the "overflow" and "under• Comment. The main conclusions of this article are that at some fill" theories of early pathophysiology in cirrhosis seems to have stage of cirrhosis, not necessarily at its inception, there is a maldis• no easy solution. tribution of blood with a relative deficiency of plasma volume in Dr. Sweeting raises the question of how definite an entity the the ECBV associated with a rise in the levels of norepinephrine. central and arterial blood volume (ECBV) is and excludes the The authors suggest that these changes are causally related, because heart of any "central underfilling" based on a previous paper by there was a strong inverse relationship between ECBV and renal Rector and Hossak (Gastroenterology 1988;95:1658-1663). vein catecholamines. There are several other studies confirming ECBV (determined according to the kinetic theory as mean transit the elevation of norepinephrine in cirrhosis (Lancet 1986;(Oct): time in the central circulation multiplied by cardiac output) is the 1880 SELECTED SUMMARIES GASTROENTEROLOGY Vol. 104, No. 6

blood volume in the heart cavities, lungs, and central arterial tree, i.e., the volume of blood contained within the arterial tree up to points that are temporally equidistant from the heart to the aortic bifurcation. The aortic bifurcation is arbitrary, but this was applied in cirrhotics as well as in controls. Rector and Hossak (Gastroenter• ology 1988;95:1658-1663) and Rector et al. (Gastroenterology 1990;99:766-779) have reported increased left atrial diameters in patients with cirrhosis and a nonsignificant increase in right ven• tricle diameter. However, taking a close look at their values ob• tained by echocardiography the average increase in the cardiac chambers is only 16 mL compared with controls (Hepatology 1991; 13:1261). This is indeed a low difference compared with our decrease in ECBV (300 mL). Moreover, it should be recalled that volume detection by echocardiography has a relatively low accu• racy (Am J Cardiol 1983;52:1249-1257). Thus, if the presence of ascites changes the configuration of the heart, volume measure• ment by standard echocardiographic procedures may not be correct (Hepatology 1990;11:662-667). Altogether, the findings referred to by Dr. Sweeting do not provide convincing points against our data. ANF plasma concentrations are the result of both release and clearance (Life Sei 1990;47:1173-1180). Thus, alterations of ANF clearance by the liver and splanchnic circulation (Hepatology 1992;16:790-793) may counteract changes of ANF release in cir• rhosis, resulting in unchanged plasma concentrations. Further• more, the missing relation to ANF in our study may in part be due to the fact that 58% of the patients received diuretics, which are likely to influence the circulating levels of ANF. Moreover, the ANF data by Angeli et al. (Hepatology 1992;16:1389-1394) men• tioned by Dr. Sweeting support our contention of a marked under• filling in decompensated cirrhosis. We agree that there is no good present explanation for the de• crease in systematic vascular resistance, but a number of potent vasodilators are increased in patients with cirrhosis (Lancet 1984;1:1480-1483; Gut 1988,29:1167-1 172; J Hepatol 1991;12: 118-123). Finally, the enhanced sympathetic nervous activity is, most likely, a consequence of central and arterial underfilling, not an etiological factor.

DR. JENS H. HENRIKSEN DR. FLEMMING BENDTSEN DR. ALEXANDER L. GERBES DR. NIELS JUEL CHRISTENSEN DR. HELMER RING-LARSEN DR. THORKILD I. A. S0RENSEN