238 3 Journal of S Sütt, E Cansby et al. STK25 in adipose tissue 238:3 187–202 Endocrinology dysfunction in obesity RESEARCH STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue Silva Sütt1,*, Emmelie Cansby1,*, Alexandra Paul2, Manoj Amrutkar3, Esther Nuñez-Durán1, Nagaraj M Kulkarni1, Marcus Ståhlman4, Jan Borén4, Jurga Laurencikiene5, Brian W Howell6, Sven Enerbäck7 and Margit Mahlapuu1 1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden 2Department of Biology and Biological Engineering, Division of Chemical Biology, Chalmers University of Technology, Gothenburg, Sweden 3Department of Hepato-Pancreato-Biliary Surgery, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden 5Lipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden 6Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York, USA 7Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Correspondence should be addressed to M Mahlapuu:
[email protected] *(S Sütt and E Cansby contributed equally to this work) Abstract Whole-body energy homeostasis at over-nutrition critically depends on how well Key Words adipose tissue remodels in response to excess calories. We recently identified serine/ f brown adipose tissue threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in f white adipose tissue non-adipose tissue and systemic insulin resistance in the context of nutritional stress.