Supplementary Table 1 Mean viability values for each cell line for each compound tested in the small molecule screen. A value of "1" represents a hypothetical, perfectly flat line (no effect).

Drug GTL-16 GTL-16_A GTL-16_B GTL-16_C GTL-16_D GTL-16_E GTL-16_F GTL-16_G GTL-16_H GTL-16_I GTL-16_J GTL-16_K (S)-Citalopram Oxalate 0.94311374 0.98629332 0.95815778 0.9297682 0.94129628 0.97543865 0.92876703 0.94308692 0.97087634 0.92498189 1.03652668 2-Ethyl-2-thiopseudourea, HBr 0.9926737 1.02483487 1.04627788 1.01238942 1.01124644 0.99179834 1.03981841 1.03206468 1.07888484 0.95669609 1.03375137 1.00257194 2-methoxyestradiol 0.95743567 1.02442777 0.96874416 0.95701057 0.96000141 0.9319331 0.96175575 0.98632097 0.97543859 1.07065523 0.9810608 1.00528908 3-Isobutyl-1-methyl-xanthine 1.07753563 0.90621853 0.91486669 0.88967401 1.00929224 0.87712008 0.86304086 0.84795183 0.8218478 0.80844665 0.86385089 0.88111275 5-FU 0.5692879 0.58485568 0.59111845 0.66370136 0.60502565 0.52588075 0.61204398 0.55819142 0.57166713 0.44119668 0.61203408 0.61352444 6-aminonicotinimide 0.67580861 0.74962443 0.74297309 0.78548056 0.69875711 0.76253933 0.72148764 0.75038254 0.72102743 0.74534333 0.77091813 A-1331852 0.93531603 0.90417945 0.94313675 0.92505068 0.94545311 0.96834266 0.88789237 0.93844146 0.94623333 0.95265883 0.84359944 0.98073947 a-cyano-4-OH-cinnamate (CHCA) 0.9952172 0.98906165 0.99838293 1.01442099 0.99624294 1 0.98471749 1.0049547 1.02723098 0.9742409 0.9819023 1.0257504 A922500 0.87694919 0.97097522 0.94563395 0.96351612 0.90027344 0.97543859 0.95685369 0.99162376 0.97543859 0.99552864 0.97768879 0.90608144 ABT-199 1.16429579 1.08221138 1.0141027 0.99331677 1.10464954 1.02660263 1.04603684 1.02137256 1.02593267 0.99139178 1.0738945 1.0436343 ABT737 0.91664159 0.9923889 1.05407965 0.9700942 0.89283508 1.00871408 0.93230343 0.98689145 1.0286752 0.96533024 0.94891477 1.04316843 acetylsalicylic acid 1.01659238 0.9979338 0.94857973 1.01929474 1 0.96629065 0.97594625 0.96813035 0.99379772 0.94024408 1.0001055 1.01547849 Alitretinoin 0.98869127 1.03639805 0.97551936 0.97847396 0.98871243 0.95675898 0.96696025 0.95001709 0.9840253 1.06605625 0.97239363 1.04783285 Altace 0.87073982 1.03982008 0.99782932 0.96493018 0.84670079 0.94735545 0.96060789 0.97058862 0.99526423 1.06157458 0.98981637 0.96154916 Anagrelide HCI 1.05837071 1.07910013 1.0464623 1.05003238 1.09089124 1.08650148 1.03727293 1.03105056 1.06632137 1.05114949 1.0688504 Anastrazole 0.99115813 1.04960859 0.99801701 0.94947243 1.0236882 0.96336734 1.02696466 0.99695414 0.97759819 0.9885264 0.9747808 1.0182724 Antimycin A 0.76865405 0.73035717 0.65301722 0.7834608 0.78227186 0.72338969 0.69951057 0.74505854 0.71001744 0.72835344 0.7763648 Apocynin 0.97543859 0.99232286 1.00482845 1.0018357 0.98933357 0.98961926 0.96391517 0.99102676 0.96731085 1.028561 0.98263758 0.97668135 Atorvastatin 0.84320343 0.88637364 0.85761011 0.88786685 0.92744112 0.89492053 0.8989476 0.86354041 0.91969699 0.86774677 0.93828964 Azacitidine 0.68160683 0.76850802 0.78691721 0.73743463 0.7508415 0.92645198 0.88798296 0.80494529 0.85260504 0.78941232 0.78597897 0.80580533 AZD1480 1.05516684 0.5808388 0.5708518 0.59790021 0.97274268 0.84303343 0.63504857 0.54799163 0.56712043 0.63054359 0.57492965 0.52439815 AZD5363 1.03660142 1.03264475 0.97480762 1.02342236 1.02716827 0.97283322 1.05016696 0.98566836 0.9744758 0.98173034 1.01834416 1.02222073 BAY 11-7821 0.83367866 0.82742381 0.8398239 0.75691718 0.79982984 0.76694465 0.76502866 0.76191229 0.76876932 0.79342228 0.82935077 0.84060133 Bay 11-7085 0.90183669 0.9032231 0.85297155 0.83557886 0.85814548 0.80442488 0.85277754 0.9507314 0.87015092 0.81668991 0.95939302 0.8565433 Belinostat 0.58585119 0.58984524 0.55198771 0.62311172 0.53826171 0.64547908 0.61591887 0.51412266 0.53659713 0.56087005 0.5439077 0.51004094 Benzofibrate 0.97543865 0.95768976 0.90309739 0.99303764 1.03130925 0.9988544 0.91316086 1.00974655 0.96932709 0.99157763 1.03401732 BI-D1870 1.00653481 1.06455576 1.08639479 1.03054297 0.95142496 1.08527851 1.04516876 1.05362809 1.04241431 0.97729003 1.072649 1.08245933 Bicalutamide 1.04075134 0.94048578 0.96631384 0.96081638 1.0026921 0.89953828 0.95612019 0.9370026 0.98999798 0.91997677 0.97406381 0.94326419 BIRB-796 0.9406845 0.88510805 0.86352462 0.88639754 1.03746033 0.88337725 0.89192021 0.852557 0.80451751 0.85053211 0.88485157 0.85409266 Bisindolylmaleimide I 0.79447883 0.77071041 0.78634983 0.75654894 0.70693886 0.68097818 0.89997333 0.85750604 0.80822361 0.75806242 0.73403537 0.75910336 BMS753 1.14387619 0.99524611 1.00422919 0.98119253 1.03567636 0.95755398 1.02452695 0.96526581 1.03066874 0.95993036 0.98410887 0.97190255 Bortezomib 0.42598787 0.36504528 0.54794055 0.48919612 0.41261989 0.50286382 0.49576858 0.47062629 0.50904244 0.52536148 0.52086037 0.48605648 Bosutinib 0.78732622 0.74653077 0.74716896 0.78953677 0.68061101 0.60852605 0.76187694 0.80148232 0.73061305 0.7210055 0.78231984 0.73420972 Brefeldin A 0.69975811 0.77177715 0.81760871 0.8136391 0.7243371 0.77431703 0.77843982 0.76636004 0.79764473 0.79391062 0.7757051 0.7513957 Bromopyruvic acid 1.01441431 1.02288449 0.97543859 1.00099742 1.01936913 0.99015832 0.97260034 1.03007793 0.98447269 1.01628029 0.98209924 1.01655972 BV6 0.95070201 0.80581135 0.79456836 0.76522732 0.89405626 0.72117794 0.81000656 0.78144783 0.75603807 0.7994858 0.80759579 0.83000571 BX795 0.8326326 0.80962682 0.79888809 0.86500263 0.7585631 0.93312925 0.81786305 0.76044267 0.77183384 0.73866659 0.82035542 0.80553973 BX912 0.70837396 0.58121341 0.5913499 0.60991174 0.66077471 0.78774565 0.62063599 0.56731081 0.57567203 0.57100946 0.56503338 0.56380934 Camptothecin 0.20894133 0.38259089 0.36735317 0.19042179 0.19720933 0.32078287 0.3279928 0.26670286 0.29759926 0.33057389 0.34511778 0.37134597 Canertinib 0.7510671 0.82200074 0.81215608 0.8408913 0.83382499 0.68709397 0.8789776 0.82378107 0.73406273 0.6547783 0.80781341 0.75155145 Capecitabine 1.07068443 1.02926111 1.0253768 1.06530011 1.01679039 0.93793541 1.02361035 0.98695672 1.00986755 1.0067296 0.98807853 1.08348918 Carboplatin 0.83013099 0.98302728 0.94078618 0.96377999 0.94137114 0.92602187 1.0379746 0.90051472 0.94743073 0.93390137 0.96844828 0.91597313 Cariporide 1.1018244 0.99898422 0.87974077 1.04940832 1.13230598 1.04628766 0.9695642 1.02885628 0.99153167 1.01112819 1.04479337 CCCP (carbonyl cyanide-3-chlorophenylhydrazone) 0.82035446 0.77923489 0.69563985 0.78734636 0.88130516 0.73593515 0.71261907 0.75006813 0.71850342 0.75384742 0.74381506 Celecoxib 1.11873269 0.87606305 0.9370687 0.90737754 0.96222585 0.92698979 0.95294422 0.87205005 0.9287219 0.88048339 0.93658185 0.91279942 Cemadotin 0.81740808 0.8573339 0.8568216 0.93641597 0.77537167 0.82901448 0.8414433 0.78843892 0.81153262 0.80342633 0.75642872 0.86246282 Cerulenin 0.79705918 0.87305528 0.79146135 0.80968487 0.79773712 0.78913617 0.80886656 0.80827105 0.83226705 0.8867746 0.85166657 0.86195236 CGK733 0.79042548 0.76854265 0.77987552 0.76550132 0.73111457 0.80862498 0.79618257 0.76800966 0.81612039 0.79762948 0.80335754 0.77891046 CGP60474 0.87239724 0.9119454 0.90213031 0.88764507 0.89206308 0.85745806 0.88436276 0.85193402 0.82045639 0.82383811 0.82102573 0.82253671 CHIR-99021 0.5828234 0.66965628 0.62213451 0.66182125 0.57654351 0.59000897 0.59886163 0.60789955 0.58976889 0.6733073 0.63413531 0.63290143 Chlorambucil 0.89733434 0.95284444 0.94750434 0.90158272 0.9428677 0.91256434 1.03503537 0.87303466 0.9277299 0.91080809 0.93689883 0.95691967 Chlorpromazone 0.75541717 0.98476666 1.0515728 0.90970254 0.71548563 0.85036635 0.97543859 0.98435044 0.95917183 0.97153389 0.98460901 1.08553421 CHR2797 0.94654739 0.87775087 0.93137068 0.89211506 0.89894849 0.78941768 0.87208623 0.87887788 0.86117679 0.89835125 0.90167201 0.91642159 Ciclofenac 0.96623486 0.77217293 0.71118975 0.73915017 0.84422112 0.7380017 0.80333006 0.65155786 0.64903492 0.67986989 0.73579526 0.74646413 Cisplatin 0.95600808 0.96731192 0.99548155 0.99059349 0.99338919 0.88061142 1.02301145 0.96743989 1.01899421 0.96915877 0.94874859 1.112728 Clofarabine 1.01809669 0.95282352 0.90600961 0.94427979 0.98169041 0.8818633 0.95967597 0.92659581 0.90833884 0.97295755 0.98265064 0.93756026 Clopidogrel bisulfate 1.19351304 0.99234265 1.03127456 1.05109465 0.98515803 1.02755177 0.89117992 0.95169306 1.01534867 1.04056871 0.99059594 0.97543859 Coumadin 1.01434469 1.05241323 1.09439468 1.05259717 0.99200523 1.02085912 1.0704186 1.06527376 1.05223489 1.0801872 1.06524324 1.01449585 CP100356 0.6555329 0.85908645 0.83995026 0.79265374 0.80409306 0.77705431 0.83131158 0.85033226 0.82632738 0.90492851 0.86411977 0.86386293 Cyclophosphamide 1.06944931 1.02101398 1.02411282 1.04312098 1.00670624 0.88926482 1.03625488 1.00134182 0.98421937 1.00694931 1.0006274 1.10068035 CYM5442 0.80616331 0.97543859 0.99240255 1.00453186 0.79247022 0.97429889 0.99702585 1.02511632 1.03009224 0.9933849 1 0.96919751 Cytarabine 0.74090928 0.71297586 0.65775532 0.70986426 0.60572392 0.69052368 0.84219593 0.61489236 0.65672958 0.65666699 0.71609515 0.55362391 Cytochalasin D 0.84181362 0.77303553 0.83960438 0.77226877 0.67960167 0.70588487 0.76513737 0.72352082 0.70135921 0.73986787 0.74505955 0.76076967 D-erythro-Sphingosine N-Octanoyl 1.01438236 1.00347221 0.97543859 1.02364767 0.97303784 1.00117862 1.02272499 1.0395484 0.97543859 1.03981674 1.01552594 1.03742456 Darifenacin 0.54694915 0.62165582 0.53592509 0.50163603 0.5776239 0.5956884 0.61470634 0.49524888 0.50098801 0.49259189 0.58787286 0.54652232 Dasatinib 1.15710568 1.00784969 1.05186403 1.07799315 1.05721724 0.87809956 1.03917408 0.96532136 1.03029621 0.9843874 0.98050362 1.03006983 Daunorubicin 0.37225711 0.43476972 0.37945518 0.38827625 0.35022476 0.42293906 0.41851526 0.38002104 0.36639407 0.40720642 0.42722109 0.409646 Decitabine 0.87915945 0.87633926 0.90444267 0.61180723 0.90576255 0.97295791 1.03911245 0.89567763 0.8599866 0.87508756 0.92879921 0.91421658 Deferoxamine 0.4977586 0.54470986 0.51263499 0.53566366 0.4917582 0.53848565 0.51853633 0.58134305 0.54477924 0.56680441 0.56264114 0.55603087 Desipramine 0.71208048 0.74542177 0.75828195 0.7717272 0.69529939 0.72994488 0.78302002 0.7054134 0.7333405 0.73845387 0.74084383 0.75938582 Desloratadine 1.02577996 1.00753295 0.97880679 1.00320518 1.05610931 0.97340858 1.01405716 1.00370264 0.96472132 0.9816432 1.00033915 0.92089844 DFMO 0.96566516 1.00876677 0.92167145 0.95448393 0.8906461 0.88824576 0.97421867 0.94735837 0.91077185 1.0050801 0.97037995 0.94511014 Dichloroacetic acid 0.96662021 0.96979582 0.99026895 1.01420534 0.96965563 0.9577145 0.9397561 0.9724955 0.85435355 0.9147113 0.97396177 0.961887 Disulfiram 0.68188524 0.7038874 0.69964105 0.68628418 0.64385086 0.68676215 0.72496504 0.6449517 0.68347621 0.65590864 0.66651255 DMH-1 0.99772793 1.010517 1.02389479 1.04069281 0.97637767 0.85149878 1.00863576 0.99595541 0.98184717 1.07104576 0.99046791 0.98554623 Docetaxel 0.72122568 0.89636183 0.86129558 0.75032616 0.73970908 0.7853542 0.86499584 0.87185502 0.8149358 0.75543237 0.82704425 0.86039019 DON (6-diazo-5-oxo-L-norleucine) 1.11993337 1.02928698 1.02788305 1.13241565 1.07486308 0.99103475 1.02363753 1.06553578 0.94456553 1.03720236 1.07777524 Donepezil 1.00719488 0.87761176 0.8377462 0.84950137 0.90916336 0.81482846 0.8397193 0.87185627 0.88675737 0.85538268 0.83126801 0.85387152 Dorsomorphin 0.92871892 0.94649911 0.8637839 0.97427702 0.92269778 0.96527594 0.97543859 0.85617733 0.96590614 0.97543859 0.9647575 1.01111078 Dovonex 0.97543859 0.98514426 0.95048976 0.99431777 0.96917707 0.82985264 0.94596428 0.95991528 0.86255628 0.95644444 0.96647733 0.9406842 Doxorubicin 0.61238205 0.5730567 0.60314113 0.60953671 0.51323372 0.59578711 0.61064631 0.57887346 0.57432294 0.55708814 0.55421007 0.60099578 Enalaprilat 0.98358417 1.01461267 1.00745535 0.99969995 0.99256629 0.96676576 0.9924702 0.99264073 1.08364189 1.02112019 0.98724985 0.97297281 Entinostat 0.95963299 0.99709624 0.94811523 0.98815155 1.01751721 1.09352684 1.00464153 0.95583892 0.97543859 1.00514877 0.95630449 0.99067873 Epirubicin 0.59247065 0.6180014 0.62829834 0.64426005 0.54632038 0.54402578 0.58700889 0.58116156 0.54682392 0.56211293 0.60563976 0.66150761 Etoposide 0.46313894 0.47982803 0.48251402 0.55865461 0.45221886 0.42564011 0.47747239 0.42095351 0.43231842 0.45685172 0.51821297 0.4328751 EX527 0.98571545 1.01860869 1.05028427 1.0179882 0.98620623 0.98968858 1.04893589 1.0116818 1.03712928 1.01375818 0.98552549 1.03556645 Ezetimibe 0.87656838 1.04211199 0.98979336 0.96567839 0.97102052 0.97798675 0.97678071 0.96987176 0.97518295 1.00760496 0.95938635 0.97543859 Fenofibrate 0.88220274 0.84022492 0.83902079 0.85647494 0.74664426 0.81763083 0.82319033 0.80576253 0.81567168 0.82497472 0.8580606 0.83770072 FK866 0.98998672 0.99639881 0.96103239 1.03863847 0.97023392 0.96411622 0.98020625 0.98220807 0.97870874 0.98723465 1.01540625 0.99955469 Flavopiridol 0.87433177 0.83113641 0.85549557 0.82508165 0.85445505 0.80265605 0.80802619 0.81430876 0.81144464 0.81053698 0.79357547 0.8037287 Floxuridine 0.16888934 0.27766308 0.38690141 0.15300179 0.21955077 0.35572511 0.27707458 0.23713356 0.23130238 0.30365342 0.37740695 0.43240076 Fludarabine 0.84724981 0.82931638 0.77939391 0.75017411 0.77767825 0.78215539 0.8895424 0.73489571 0.71152192 0.74865472 0.77687979 0.81501347 Flurofamide 1.01591325 0.92628348 1.12392449 0.96097553 0.99298292 0.86095381 1.05211115 1.08286512 1.20471108 1.04344845 1.11415172 1.1487602 Fluticasone Propionate 1.06410193 1.06679416 1.01424336 0.88598931 1.01396239 0.75055873 0.97644228 0.96415055 0.94532514 0.93166584 0.94491637 1.00883758 Forskolin 1.17703736 1.17440903 1.22854674 1.12478268 1.17201507 1.1186775 1.15017426 1.26216745 1.17710066 1.24858499 1.30603123 Fosamax 1.00496972 1.02705383 0.95953518 0.97581488 0.98943281 0.92403591 0.96244836 0.9919939 1.04116583 1.07391775 1.01100993 1.09727335 FR 122047 0.76089966 0.99844104 1.03073943 1.01468503 0.75382143 0.99483949 1.01906621 0.93225127 0.98865879 0.98181838 0.96650928 1.0582782 Fulvestrant 0.80556089 0.86307603 0.91673684 0.93914479 0.84973788 0.78800845 0.86638188 0.78474844 0.88059962 0.90346557 0.95277792 0.9204042 Vinblastine 0.9427591 0.97425354 0.99106801 1.04403496 0.94137639 1.03727877 1.00853193 0.95136863 0.906012 0.90414506 0.877711 0.9442417 Nocodozole 0.50879705 0.67503846 0.72432375 0.65609002 0.52618629 0.54959059 0.60855627 0.57254398 0.56296301 0.60150009 0.67880023 0.7121734 Erlotinib 0.98749214 0.94501299 0.95376235 0.96740735 0.95146918 0.6050393 0.97561425 0.93303698 0.92238557 0.95641524 0.93131995 0.93029392 Verrucarin A 0.43469951 0.63754171 0.65310311 0.62830561 0.5611499 0.71915942 0.63053757 0.59487075 0.54257816 0.58342141 0.58885491 0.58424634 GDC-0879 0.90791702 1.10185373 1.04535389 1.07204998 0.49665302 1.02044082 1.12009168 1.03541768 1.13206208 1.06925452 1.02849853 1.10022652 ZM 447439 0.93243676 0.71658742 0.56914425 0.74516463 0.79645646 0.76050037 0.74152941 0.74282664 0.68281925 0.7745589 0.71833611 0.73203498 Lapatinib 0.91376132 0.87495065 0.87679309 0.8631801 0.82446545 0.66082209 0.87315565 0.94245017 0.92430609 0.89275092 0.86840373 0.89898849 SNS-032 0.64692569 0.64225513 0.55619782 0.62743491 0.68626201 0.6638521 0.6858114 0.65636259 0.63724977 0.62819213 0.63492006 0.58647066 PD901 0.37526929 0.42819867 0.45805275 0.42387208 0.09862114 0.34264308 0.43074673 0.43732435 0.36775225 0.4607482 0.43241879 0.38289171 Olaparib 0.86127943 0.96501744 0.97623152 0.89960027 0.86396247 0.94121993 0.95150018 0.94818103 0.91616869 0.94539726 0.93832487 1.03393972 BI2536 0.67492837 0.78836471 0.79634005 0.96124184 0.75865304 0.8520118 0.90713096 0.75029767 0.7878378 0.78154469 0.85750777 0.73782879 MLN8054 1.07453632 1.04793048 1.05704772 1.03688049 1.11554646 1.03188765 1.05744553 1.01012838 1.03183699 1 1.03740966 1.02779508 AZD1152 0.902412 0.84668261 0.84566903 0.90592575 0.84677827 0.85699004 0.85072184 0.82289308 0.83542407 0.85837841 0.86099762 0.85506892 Idelalisib 0.99491531 0.95264047 0.97795922 1.00126839 1.03912306 0.91072059 0.97543859 0.98138726 0.94341034 0.93448687 0.93970907 0.9249903 Lenalidomide 1.0006026 0.6934374 0.79174352 0.69627637 0.77420717 0.57105863 0.6713056 0.71207958 0.68092173 0.74476862 0.74188036 0.71737725 Vemurafenib 0.97642642 1.0309366 1.04187417 1.00375557 0.69243121 0.86170709 1.01347744 1.01486826 0.95679182 1.03803444 0.97950029 1.01495051 PF-01367338 0.95347255 0.92391956 1.0156132 0.92084014 0.83326232 0.8405844 0.97543859 0.93966722 0.89475483 0.91023564 0.93184131 1.08000815 ABT-888 0.99863392 0.96763825 1.0379132 0.89042825 0.94562751 0.99276674 0.98698717 0.97532851 0.97163308 0.94689792 0.97066981 1.05293655 Navitoclax 1.07497835 0.95281249 0.82298762 0.89104122 1.01149738 0.98907757 0.93993133 1.01848185 0.88864529 0.96567494 0.8667165 1.02142537 GDC-0349 0.70509309 0.69886976 0.66561985 0.71847796 0.63285786 0.7332049 0.67178255 0.67620778 0.66515976 0.65567821 0.73170578 0.66198695 Quinidine Hydrochloride Monohydrate 0.97388148 1.0938946 1.02880657 0.95719278 0.91031599 0.99364626 1.03463602 0.99632448 0.99481374 0.9992643 1.04979587 0.99321038 MK-2206 0.96890426 0.94800961 0.97326404 0.95576113 0.96298569 0.91446525 0.98083442 0.94066423 0.89285803 0.90337783 0.93763161 0.89145648 Monastrol 0.98091358 0.96822214 0.93312669 1.10356081 0.97543859 0.97276127 0.98006916 0.98747498 0.93603837 0.99103469 0.95918077 1.02647483 Necrostatin 0.94237077 0.99862087 0.995471 0.96058738 0.96414679 0.95387751 0.9869898 0.96812361 1.02284038 0.92491031 1.00717759 0.97515512 SU 9516 0.91766858 0.90766776 0.97699165 0.99657393 0.90046465 0.92240024 0.96438426 0.96656799 0.87218857 0.92530125 0.97879875 0.9787876 Verapamil 0.86417133 0.84372127 0.80972511 0.84336162 0.91151685 0.90307331 0.86568516 0.84212124 0.78954911 0.82522869 0.84908342 0.87005061 SNS-314 0.81639922 0.9675498 0.99181682 0.99038231 0.95090383 0.95747006 0.95884639 0.90650636 0.9423843 0.9546293 0.95258445 0.95133185 Diazepam 0.84331262 1.03275692 1.06925046 1.05800879 0.86207086 1.05836797 1.06744063 1.00510621 1.04751909 1.02335715 1.0239625 1.02369702 Dexamethasone 0.9619804 1.00662041 1.01340175 0.97881824 0.8924495 0.97410494 0.97543859 0.97543859 1.0078516 0.98377436 0.97543859 1.13153243 Quinacrine dihydrochloride 1.01381433 0.84196204 0.83541918 0.89059699 0.84012502 0.84821171 0.87266946 0.84813654 0.86218917 0.85782534 0.87826169 0.84862179 Chloroquine 0.96385098 0.99823898 0.99903762 0.94662881 0.91970706 0.94513267 0.95353734 0.93833685 0.99854696 0.94760525 0.95321518 0.95010269 Capsaicin 0.95283824 0.97543859 0.9804883 0.98787796 0.95464164 0.95796537 0.97543859 0.97543859 1.02161491 0.94344026 0.97543859 0.96799451 Lansopraxole 0.73936969 0.8867501 0.87611043 0.98390508 0.89093655 0.85595608 0.88088959 0.8816129 0.89309698 0.88950586 0.88383061 0.93826979 Bromoenol Lactone 1.09093189 0.99840599 0.98572409 1.01725519 1.08981454 0.9689604 1.02411759 1.00938964 1.03210938 0.98888826 0.99080437 0.99384761 AZD5438 0.85918319 0.97973877 0.95817351 0.99999988 0.8490904 0.92711091 1.00235426 0.95520002 0.95721984 0.93657404 0.94440794 0.97836822 Sodium Oxamate 0.95206887 0.96271127 1.0356276 1.01657617 1.03858078 0.96194869 0.94098663 1.02554643 0.93102235 0.96610248 1.04026079 BIX-01294 0.90001732 0.84390938 0.85227913 0.8994574 0.85681814 0.85888511 0.93907124 0.84581417 0.88598192 0.90670323 0.88233227 0.86645502 Enzalutamide 0.93798816 0.93888819 0.99401754 0.99755639 0.95382124 0.98274821 0.98455453 0.92996925 0.9169805 0.95856839 0.97866488 0.9678396 Pifithrin-alpha 1.1076622 1.00999594 1.00556326 1.03681517 1.04600263 0.93572891 0.98991722 1.0177058 0.98226619 0.9561463 0.99337375 0.99120939 NS3694 0.90120596 0.96429938 0.94175702 0.93185389 0.89493328 0.92043442 0.9112227 0.93728399 1.00975823 0.9684937 0.98600256 1.06064963 MLN518 0.99416739 1.00871205 1.00455201 0.97812313 0.99026829 0.98361063 1.00934124 0.98452902 0.97543859 0.99745202 0.98556733 1.01324928 Roscovitine 1.01446009 0.91150934 0.84428459 1.00394201 0.9536261 0.92261267 0.96840554 0.97642195 0.93589211 0.97541553 0.92871219 1.00620866 PD 0332991 1.11488438 0.88019961 0.86346757 0.95979494 0.95418471 0.89661354 0.88571364 0.85590655 0.85447061 0.85981727 0.8993715 0.84336203 Trichostatin A 0.55937403 0.34910879 0.49575919 0.59075695 0.54489523 0.59251004 0.4764643 0.4973098 0.50178432 0.54224861 0.55188763 0.45522603 Captopril 0.87587368 0.99184752 0.97757721 0.9836297 0.87247974 1.01406407 1.00588274 0.95123118 1.00657296 0.98078048 0.98535103 0.9943521 VX-765 1.07500041 1.07151747 1.10455048 1.0311681 1.0663631 1.06628239 1.08090675 1.04751611 0.99658298 1.04104757 0.99127346 1.10717559 Trametinib 0.50050265 0.51105595 0.55819649 0.59212708 0.17183694 0.45452085 0.55388409 0.48356494 0.44354981 0.53721106 0.4904719 0.43103799 LY2835219 0.90782809 0.73977792 0.73473549 0.85065031 0.64141035 0.64214081 0.73568451 0.74918604 0.63068694 0.74647266 0.7669028 0.6718027 AZ3146 0.62615764 0.78725123 0.79511815 0.8379783 0.71778464 0.77850282 0.82102275 0.80933106 0.76870906 0.74862993 0.79860193 0.82034421 E-64d 1.01881468 1.00898778 1.03512478 1.02823937 1.01575911 1.06737828 1.0530057 1.0373894 1.06356859 1.0245744 1.03609622 1.04979169 GDC-0339 0.78470802 0.79427671 0.77434862 0.8385337 0.77931875 0.73577583 0.82242572 0.80895889 0.71361059 0.74403602 0.87338281 0.79443043 R428 0.96664977 0.87739962 0.95049405 0.86442918 0.87769902 0.95637256 0.87977403 0.85549921 0.8593418 0.88653654 0.89353412 0.84545791 CX4945 0.93642545 1.00958061 1.02252221 1.03984332 0.77495944 0.93184966 0.99465501 0.9439798 0.96413481 0.98926717 0.97934973 1.03162324 NSC 663284 0.82002288 0.69965059 0.61727077 0.67182726 0.73169303 0.68239522 0.69732237 0.7124542 0.65802807 0.69778472 0.707259 0.74451023 VER155008 0.89379805 0.85605329 0.85150903 0.85780531 0.79418671 0.8237623 0.86363047 0.81612957 0.83253604 0.85148567 0.88156134 0.88105369 Geldanamycin 0.48188213 0.61497623 0.57838428 0.58442742 0.47982755 0.52473062 0.62350094 0.58580083 0.55264223 0.58499688 0.62347943 0.59356505 Irinotecan 0.76766801 0.79350132 0.80468011 0.62611556 0.68270087 0.7557649 0.79084855 0.68973416 0.81455654 0.78269756 0.77254438 0.86400807 EHT1864 0.91929364 0.85691541 0.9827801 0.91961712 0.9979881 0.97955984 0.92973381 0.92209262 0.89540243 0.91768783 0.93004084 0.93689561 PD 166285 0.64018458 0.55824083 0.52787918 0.58964795 0.50262105 0.62465537 0.54742193 0.53451943 0.49449772 0.53713661 0.54962248 0.49085805 BML-259 0.83598155 1.03104126 1.01357579 1.06391323 0.95707369 0.95666021 1.0285542 0.99804658 1.01070976 1.03004444 0.99656516 1.02099717 Im-54 1.12059963 0.95359141 0.96095711 0.96873558 1.08450115 1.04553819 0.99788141 0.95042849 0.98898369 0.94658196 0.96980172 0.96694368 Phlorizin 0.98961502 1.0243839 1.04476488 1.01766431 0.99743038 1.02397847 1.00978911 0.99590927 1.03540134 1.00396085 1.00609028 1.00912082 KU60019 0.91562104 0.94614983 0.96513098 0.93658996 0.81607383 0.84229851 0.97543859 0.89446348 0.8879863 0.93045074 0.97543859 0.9270767 BIIB021 0.48737422 0.65111297 0.6864627 0.66961128 0.50105745 0.56044716 0.67037421 0.69692761 0.61519158 0.61755717 0.74012911 0.68874615 UPF 1069 0.9582805 0.97593832 1.07181525 1.00061095 0.95079172 0.97882771 1.0109427 1.01098561 0.97543859 0.98755443 0.96016657 0.90470433 Golgocide A 0.85872394 0.81704527 0.82778138 0.79278404 0.82050091 0.82903934 0.90133363 0.84015042 0.84309399 0.83549702 0.84808916 0.80392897 1-oleoyl lysophosphatidic acid 0.77902466 0.99643821 0.99419695 1.01277351 1.06938362 1.03824723 1 1.00005817 0.98187053 0.98840111 0.98396432 1.01320064 zVAD(Ome)-FMK 1.08270752 1.02737606 0.95404714 1.02430427 1.07165194 1.00867665 1.00781989 1.03676188 0.99137717 1.01052809 1.07748556 1.02544463 Vardenafil 1.03523743 1.00562918 1.05503869 0.97543859 0.9381541 1.02098811 1.02735221 0.97543859 1.00565124 1.02227521 0.99334091 1.01420891 AM114 0.9178977 0.72683245 0.74334359 0.73336112 0.80550694 0.76673377 0.75869179 0.73541248 0.72381055 0.71841729 0.75874954 0.74889815 Mirin 1.03480959 0.96128875 0.96140933 0.97858059 0.9615767 0.86954945 0.95436406 0.94486493 0.96389133 0.99624163 0.92949998 0.98808247 MG-132 0.68211675 0.68670678 0.66273278 0.67102367 0.61536998 0.68620515 0.67039663 0.66578346 0.67708588 0.62330294 0.6705749 0.68170291 Ro3306 0.84431112 0.97008103 0.96824437 1.02981126 0.94273245 0.92156518 0.97543865 0.99799752 1.00038755 1.00155604 0.93095881 1.04550517 Carfilzomib 0.75665295 0.75040162 0.70969665 0.69672263 0.70800012 0.75691932 0.76182187 0.74438828 0.72358799 0.69700199 0.74286973 0.70998824 AVL-292 1.01936722 0.7412129 0.71818507 0.81721032 0.88067299 0.92756838 0.76804757 0.69800586 0.66927832 0.7693634 0.72771341 0.65909642 SBE 13 1.1393919 0.97751719 1.0013361 0.98722053 1.13520288 0.98774761 0.98741889 0.94463432 0.96891212 1.01884758 0.95703381 0.98079115 ON-01910 0.53991073 0.93785518 0.77994895 0.87328714 0.55278945 0.55132478 0.7407347 0.72105098 0.72039139 0.70271218 0.742006 0.7457425 Ibrutnib 0.9341774 0.71835417 0.71872711 0.71921939 0.8870976 0.5791747 0.71776175 0.67994744 0.75249654 0.71826124 0.72369397 0.70024663 GSK-J4 0.80365795 0.75431907 0.7447511 0.80232626 0.67574072 0.80612528 0.77858543 0.77564836 0.77261513 0.78175175 0.77422196 0.76507616 Senexin A 0.90752643 0.91005653 0.88401675 0.86250728 0.85536343 0.86606681 0.87990093 0.88282317 0.90000188 0.83941251 0.88209867 0.89454043 Dabrafenib 0.86245883 0.90237164 0.88682544 0.95713168 0.27215651 0.8904587 1.04444528 0.89996791 0.86463362 1.00552773 0.91966069 0.81557882 GSK-J5 0.93968946 0.97543859 0.99952924 1.00097561 0.92533398 0.99193871 1.00541174 0.97443241 0.98320305 0.99335635 0.98903322 1.01077425 PF-03814735 0.80701405 0.63886321 0.66375589 0.65419501 0.74687618 0.74781096 0.66806936 0.60138685 0.57414025 0.62291849 0.63172835 0.61590159 GSK126 0.840249 0.86634076 0.80334133 0.96755177 0.87716007 1.03738415 0.97172385 0.87512457 0.8631478 0.86701274 0.85742855 0.85017169 GSK2801 0.97129297 0.93051171 0.95036644 0.96766931 0.96518058 1.06475306 1.06299269 0.9535116 0.99362242 1.00688004 0.96192521 0.98654819 PFI-2 0.96293038 0.92692614 0.95185769 0.93734336 0.95323384 1.05074918 1.04883838 0.90598172 0.96235687 0.96772552 0.97946346 0.95335251 EPZ-6438 0.97543865 0.94464153 0.94238126 0.9814018 1.00962472 1.11360466 1.07586598 0.95898604 0.97543865 0.97915024 0.96379346 0.93381745 Narciclasine 0.32676584 0.32341656 0.3223241 0.28423089 0.27233109 0.31358606 0.29573753 0.32842427 0.29987136 0.30844319 0.33007318 0.31112373 Vinorelbine 1.10393798 1.06641197 1.08277798 1.12111402 1.08297646 1.04186702 1.08935177 0.9901318 1.1340282 1.08556736 1.04596269 1.08677769 Cytochalasin D 0.84838647 0.74747241 0.79529256 0.77696544 0.65715778 0.69932026 0.75892079 0.71587139 0.72319543 0.75819427 0.74737102 0.74305254 17-DMAG 0.5816142 0.49932811 0.47969055 0.50492251 0.54175484 0.48833445 0.51244658 0.52189326 0.46492568 0.45964861 0.46931848 0.51053602 UNC1215 0.94565034 0.95119601 0.96354282 0.99128395 0.98801172 1.21758413 1.11544156 0.94420761 1.00735831 0.96160674 0.97855502 0.96643591 CARM1 7f 0.98424721 0.89486617 0.94088084 1.01055348 0.99063486 1.07890916 1.03029883 0.95187587 0.96290082 0.98045731 0.986696 0.9643988 MK 0822 0.85324121 1.03289914 1.01228523 0.98284423 1.00303972 0.99871105 1.03379107 1.01146448 1.02180946 0.99140364 0.98417515 0.97445303 17-AAG 0.82795709 0.80665082 0.82453173 0.84446216 0.79903996 0.86634338 0.8619172 0.79165596 0.84753913 0.84778512 0.87993187 0.84473193 Cruentaren A 1.03103721 0.80574268 0.75284839 0.9919157 0.97017336 0.86834478 0.79134828 0.79595047 0.84038138 0.888668 0.86396921 Taselisib 0.80452651 0.85506403 0.78424948 0.85457712 0.8928948 0.64376187 0.86851352 0.86219853 0.74275827 0.68246585 0.84314758 0.78361088 Ipatasertib 0.80032468 0.94103378 0.9089669 0.93560779 0.88381624 0.91587007 0.93723601 0.88935483 0.7716192 0.83835733 0.89795941 0.88746244 GDC-0084 0.73126894 0.67300051 0.65441602 0.71381718 0.67835259 0.65316492 0.7170524 0.65036142 0.60242325 0.59824657 0.72875094 0.64299929 GDC-0623 0.5862388 0.56470615 0.57594311 0.59534574 0.50725287 0.46089497 0.61801577 0.52489007 0.55544877 0.62751204 0.54996103 0.52887326 GDC-0917 0.93154311 1.00318074 1.03549552 0.94217908 0.9252094 0.97398239 1.0055356 1.0017823 0.98635483 0.99910432 0.99612892 1.14263177 Pictilisib 0.98487836 0.90373713 0.85950965 0.97543865 0.95257479 0.90222484 0.9461391 0.94368547 0.87418306 0.86593378 0.93333662 0.88421488 Cobimetinib 0.60525084 0.62933558 0.6478954 0.61405081 0.17423017 0.55087817 0.64431542 0.61116856 0.5885343 0.62149668 0.60144567 0.56110001 Apitolisib 0.59163153 0.63439232 0.60499734 0.65349948 0.57952565 0.64549899 0.65533674 0.55137002 0.51729393 0.55849952 0.68035871 0.62004036 GDC-0994 0.91122437 0.84412861 0.8780213 0.84453768 0.46202347 0.80320179 0.90273637 0.86135489 0.82799029 0.89621556 0.89987826 0.85842842 Gefitinib 1.02726102 0.97543865 1.05014682 0.9689011 1.0236764 0.80646974 0.95246214 0.97696185 0.95560217 0.98669273 0.98501432 0.86298746 Gemcitabine 0.94836068 0.97543859 0.96840906 1.02694452 0.92951226 1.00291491 1.02465296 0.98977947 0.99837053 0.99601531 0.98720866 1.05425072 GGTI 298 1.08422971 1.0231657 1.0623945 1.08170855 0.92270941 1.00711524 1.11495697 0.97147489 1.01613379 1.03822982 1.03720891 1.0780437 GSK 3787 0.94034982 0.97818279 0.9898361 1.05040467 0.8849864 0.99140733 1.02185261 1.05152309 1.07854986 1.06548464 1.02222228 1.04256189 GW 441756 1.05155885 0.68446296 0.71298593 0.71177429 1.03194237 0.73629969 0.86471146 0.67514336 0.70286554 0.63739586 0.70207667 0.61947584 GW 843682X 0.86975765 0.7894901 0.62650883 0.78009969 0.82528234 0.84539646 0.79397959 0.81045622 0.77629781 0.76384211 0.77643085 0.76003098 GYKI 52466 0.99801958 0.98633879 1.03675008 1.01736116 1.03369069 1.02582157 0.99548835 1.0301162 1.02709043 0.97001696 1.02741933 0.99516153 H89 0.86852592 0.83968794 0.82150316 0.8687762 0.82283282 0.86459869 0.82940006 0.88404071 0.80223346 0.83496046 0.84512663 0.85214061 Hydralazine 1.12037206 1.11562026 1.12599695 1.146456 1.03658557 1.01066172 1.12298608 1.02448273 1.05405426 1.08397603 1.09104705 1.1198777 Hydrocortisone 0.93324596 0.88400978 0.88771617 0.86298156 0.93937159 0.8669579 0.82793576 0.84580088 0.87570208 0.8781684 0.86968523 0.87289518 Hydroxyurea 1.02888536 1.01345229 1.02232289 1.03258014 0.98587608 1.02178502 1.0006547 1.0169512 0.97683662 1.00810814 1.01561403 0.99565768 Ibandronate 0.99167234 1.02385736 1.0394491 1.01966441 1.00670719 0.96604037 1.00011337 1.0293926 1.05462229 1.05488515 1.00382411 1.02273977 Ibuprofen 0.85668504 1.01300359 0.99769938 1.01225722 0.92818081 0.94536096 1.07826996 0.96145636 1.06330836 1.04506755 0.95891368 1.09002471 Ifosfamide 0.87182748 0.90286011 0.9049598 0.77041906 0.80592245 0.75959182 0.86988163 0.86063325 0.85440975 0.83749378 0.92837238 1.00481999 Imatinib 0.9060865 0.85776198 0.88111943 0.86258656 0.89720976 0.87662381 0.89216733 0.92180419 0.9099161 0.88707858 0.85535085 0.85519248 Imiquimod 0.95522738 0.96399295 1.04116654 1.00237274 0.99178249 0.99010813 0.97429836 0.99523222 0.97325099 1.00192261 0.98415327 0.85460424 INCB018424 0.95571041 1.00456274 1.01067603 0.9990378 1.00990844 0.92903078 1.14422154 0.98706007 0.99397588 1.07875943 0.99010688 1.0068804 INH1 0.92993003 0.89343578 0.89389396 0.97504407 0.93931907 0.85431105 0.87260556 0.91287637 0.89597088 0.9145267 0.88340241 0.92588061 Ionomycin 0.66547513 0.8809436 0.86513406 1.00333548 0.59525442 0.83529162 0.89337397 0.85409886 0.86302948 0.91837996 0.85868514 0.87356919 Irbesartan 0.97207898 0.78070331 0.74449027 0.738886 0.83094215 0.72105837 0.77703249 0.8001281 0.78529114 0.7567504 0.7611807 0.79492116 ITX3 1.17850769 0.99698079 0.90376735 1.0001322 1.07776618 0.89771998 1.06704998 0.97477466 0.95459408 0.91447014 0.87678432 0.87812293 JQ1 0.87577617 0.86839467 0.87125117 0.98585445 0.86855739 0.88578612 0.84740335 0.83043116 0.937213 1.00465596 0.92260116 0.85945785 Kifunensine 0.97543859 0.87365574 0.85608691 0.94970208 0.90117794 0.91680944 0.92144907 0.92741221 0.8822155 0.87497777 0.88152373 0.90112984 KU-55933 0.89632201 0.93869781 0.91793334 0.98750585 0.88166916 0.99110812 0.9360376 1.02951312 0.9239403 0.8928588 0.90494573 0.84461743 L-Mimosine 0.89318228 0.99904668 0.97543859 1.03187168 0.85331118 0.98625302 0.92256981 0.8782742 1.0067246 1.03200448 0.98515987 1.0334934 Lonidamine 0.79362422 0.97543865 1.05731881 0.94044113 0.97543865 0.91735941 0.93581617 1.02121687 0.99580836 0.95128828 1.07018626 Lovastatin 0.74823356 0.76409709 0.83577347 0.81085825 0.88417232 0.8273682 0.82882279 0.83379805 0.83127469 0.78646153 0.83263028 LY 215840 1.00440609 0.96589595 0.92216986 0.9345597 0.96289372 0.98786831 0.96133435 0.94345474 0.98020965 0.9253388 0.98848599 0.87161845 LY 78335 0.99818814 0.98773891 0.99245048 1.0279671 0.9943856 1.02078676 0.97518653 1.01172841 0.97644132 1.08464098 0.98618925 1.02549732 LY2157299 1.07681298 0.7894116 0.78552437 0.74382079 1.01219225 0.77905238 0.80097115 0.75801331 0.72070479 0.73732132 0.71225774 0.75786495 LY2228820 0.41810834 0.48165959 0.5067091 0.47598889 0.49876609 0.49478236 0.48234108 0.46135482 0.50265443 0.48263398 0.47981748 0.4803623 LY294002 1.0626359 0.97543859 1.02779984 1.02663946 1.01923716 0.9889465 1.04607511 1.01190007 1.03604484 0.98653859 0.92175728 0.95732403 Mechlorethamine 0.41609418 0.49197698 0.48302352 0.30854467 0.41559094 0.41099989 0.46571052 0.42473087 0.43308577 0.45793706 0.44892317 0.50272602 Melphalan 1.02332032 0.92927861 0.94848621 0.87076795 0.89890379 0.86743861 0.93178177 0.89571977 0.91887593 0.93130291 0.9699319 1.03088391 Merbarone 0.87529349 0.8934232 0.90642327 0.88167888 0.81741989 0.89768988 0.93129593 0.86122882 0.86706758 0.89897364 0.93718976 0.83345419 Mercaptopurine 0.7901848 0.89244676 1.053339 0.9347381 0.70977229 0.89649135 0.92502367 0.91229308 0.91376382 0.9039706 0.94947046 0.94636858 meso-Tetraphenylporphyrin iron(III) chloride 1.00146019 1.00396788 0.99649549 0.93711227 1.04717529 0.97341663 1.02981973 1.01635218 0.99128538 0.99509764 0.97603095 1.017802 Metformin 0.98865908 0.99419785 0.96206981 0.97747165 1.00605607 1.00451016 1.01506603 0.95075619 0.97563106 1.0180583 0.97755975 0.92211032 Methotrexate 0.274391 0.31796759 0.34900108 0.35048199 0.3059181 0.34478354 0.37117466 0.33014819 0.32649076 0.30983588 0.36828196 0.32969609 Methoxsalen 0.98007941 1.03830922 0.97282255 1.04231811 1.04720581 0.97543865 0.99009991 1.06168985 0.96669358 1.00921667 1.08493257 Mevastatin 0.72686142 0.83711821 0.80848515 0.81052417 0.78736299 0.81730819 0.82775378 0.83188313 0.83575046 0.85308993 0.95286131 Mitoxantrone 0.6091758 0.62849969 0.65022308 0.71012974 0.52894837 0.51265812 0.65393734 0.56586766 0.54530603 0.5454011 0.64271957 0.64033073 MK 886 0.76671982 0.75215042 0.7555266 0.82549798 0.76516575 0.81722957 0.78977191 0.74709344 0.74112672 0.78247607 0.78660232 0.81223756 MK-1775 0.63369131 0.68944067 0.63865173 0.5991621 0.62933213 0.66279739 0.71567345 0.63016498 0.63787603 0.67575461 0.6683315 0.65683764 MLN4924 0.61789489 0.70388514 0.70300621 0.72460359 0.62934899 0.66198361 0.72921175 0.63601881 0.63593262 0.61822331 0.68448275 0.6580112 Mometasone Furoate 1.18700969 1.02622175 1.04945683 1.0914098 1.05979836 1.01725125 1.11550415 0.96008509 0.97337627 1.03084242 1.08433235 1.09604239 Mycophenolic acid 0.98933983 0.99127012 0.93076831 0.96858495 0.99333256 0.9800027 0.90725207 0.97552383 0.9321807 1.00799608 0.99840438 NG-Nitro-L-arginine (L-NNA) 0.97159183 1.04381692 0.97835952 1.04885352 0.96891308 1.0401001 1.0108211 0.940323 0.90174896 1.02676213 1 0.98919427 Nilotinib 0.97543859 0.94352329 0.94683725 1.00590086 0.85975891 0.96841532 0.98673767 0.91914213 0.95669901 1.02654684 0.96793622 0.93411916 Nordihydroguaiaretic acid 0.75991583 1.01078701 1.04534614 0.97812378 0.71827674 0.94200099 1.03722608 0.91222829 0.94948781 0.98514628 0.92008269 1.03608584 NS 2028 0.93883348 1.0197717 1.02679694 0.99801439 0.97284555 1.01698089 1.00513566 1.0056659 0.97833776 0.98508662 0.96520203 0.97534639 NSC 23766 0.936643 0.81754142 0.83176136 0.90763909 0.85272241 0.83196056 0.87770158 0.85990208 0.84463465 0.79731321 0.86124653 0.81451643 NSC 66811 0.95042014 0.98820317 0.95050621 0.93166608 0.99283874 1.02344334 0.97312391 0.99208325 0.99238408 0.97551763 0.97190243 1.05753326 NSC625987 0.86473048 0.92884088 0.93622607 1.09155548 0.93084425 0.95048523 0.96234441 0.95341557 0.91737622 0.98806852 0.97954702 0.98972696 S31-201 1.03411484 0.95170784 1.00804961 0.9115904 0.87970078 0.93441159 0.96856838 1.00930464 1.02185965 0.9263646 0.95757812 1.06741703 NU 7441 0.81314027 0.83649725 0.82705081 1.00024033 0.83448607 0.91287136 0.96674293 0.86246753 0.88094378 0.88837731 0.91651589 0.8014276 NU7026 0.99479002 0.99591368 0.96161532 0.98587811 0.90568841 0.86501765 1.05561137 0.96280658 0.94579947 1.04881382 0.97814214 0.9709152 Nutlin-3a 1.0335114 0.92968488 0.91036838 1.00114834 0.96789241 0.85907519 0.88069606 0.9445945 0.89670134 0.92826623 0.91706085 0.93922591 NVP 231 0.92718536 0.92035276 0.93019742 0.96320456 0.91780788 0.9422999 0.90163904 0.92092478 0.94772542 0.8901279 0.93274873 0.93114364 NVP-AEW541 0.82079399 0.72498095 0.694076 0.70793152 0.72430193 0.73748326 0.71467316 0.74520063 0.62481558 0.64103514 0.72678977 0.70299745 NVP-AUY922 1.18423092 0.97420138 0.97001934 0.98345667 1.15087497 1.06630778 1.02958429 0.9848935 0.98294234 0.99544644 1.00575948 0.96739233 NVP-BGJ398 0.89188039 0.52237737 0.519943 0.51179779 0.87061614 0.87827617 0.51593286 0.50697219 0.4849126 0.48986328 0.5536533 0.45249501 ODQ 0.98869473 1.05483878 1.00176179 1.00810814 0.97543859 0.9880864 0.96229011 0.97543859 0.90017319 0.98661274 0.98631954 0.95312548 Orlistat 0.82453376 0.94964468 0.93215299 0.96710831 0.88227952 0.887398 0.93780667 0.97192305 0.87791216 0.88901085 0.93811506 0.87407047 Oxaliplatin 0.70157671 0.71285832 0.65944439 0.66316736 0.70035565 0.6049692 0.68205631 0.62605613 0.63257712 0.62893242 0.747769 0.65293962 Oxythiamine 0.99479407 0.98800445 0.95913738 0.99370724 0.95934957 1.03982067 1.00333261 0.95652634 0.99914885 1.01469982 0.9967913 1.00282741 Paclitaxel 0.94902915 1.02116406 0.98642588 0.9494459 0.93210793 0.89044446 0.94847053 0.93880278 0.89692444 0.87843746 0.86954397 0.93217802 Pamidronate 0.98343366 1.07871187 1.17505682 1.06728041 1.00903821 0.97629291 1.1568867 1.02636552 1.11860371 1.1333766 1.1662823 1.20110154 PD 166793 1.03071201 0.9493674 1.06687915 1.04192388 1.04306996 0.9882108 1.03724623 1.00339878 0.98457992 1.02240682 1.01518977 1.02086043 PD173074 0.8751362 0.48554853 0.45967746 0.45996583 0.85621107 0.76435935 0.45205301 0.46052256 0.43500125 0.44678873 0.449561 0.40231454 Pemetrexed 0.56795436 0.60246289 0.5689562 0.53421998 0.59051496 0.56111807 0.6928528 0.48680022 0.52827048 0.55026966 0.60322535 0.60062057 Pentostatin 0.51825637 0.50785249 0.45883822 0.38110036 0.42408809 0.47658342 0.54546797 0.35656095 0.42786163 0.44772211 0.52801627 0.39845473 PF 998425 0.92935139 1.02458775 0.82808781 0.99436551 0.85677904 0.87527204 1.04140496 0.92691302 0.97543859 0.98007983 0.94910485 1.00271547 PF-2341066 0.82665193 0.95551729 0.96204048 0.99038428 0.98365867 1.01641893 0.97915816 0.95471716 0.97923869 0.96909577 1.02282476 0.94359195 PF-4708671 0.85254234 0.93582535 0.92427838 0.9077903 0.98373437 0.96523654 0.92134595 0.90618944 0.92401117 0.88605899 0.94831449 0.94385374 PF573228 0.8966133 0.71683633 0.70731091 0.69302166 0.91883218 0.96376097 0.69123787 0.63902515 0.70121926 0.67271727 0.66138166 0.65640992 Phloretin 0.89179271 0.96175611 0.99790317 0.94458401 1.01992428 0.94306946 0.94506162 0.98827016 0.91739273 0.98870766 1.07651722 Piceatanol 0.86237252 0.93318349 0.97434914 0.93369424 0.95893675 0.96570891 1.00573123 0.98363364 0.96732247 0.94102824 0.9150331 1.00380695 Pindolol 1.01832616 0.9557752 0.97952199 1.03031981 1.08828485 0.96390074 1.03360844 1.00493109 1.00662208 0.97985107 1.0003475 0.9232856 Pioglitazone 0.8451578 0.99262452 1.04613864 0.98054117 0.9105708 0.9622426 0.98363924 0.97392404 1.04203784 1.01392651 0.99807626 0.99961901 PKC412 0.84006357 0.76614356 0.78480846 0.75636047 0.70814955 0.82814372 0.74797064 0.79208088 0.74715382 0.76249564 0.79109246 0.77212805 PLX4720 1.04959905 1.00673962 1.01978433 0.98152125 0.47658241 1.03810215 1.07056749 0.95702386 1.02155709 0.9935475 0.95018297 0.95355499 Ponatinib 0.88387799 0.5977993 0.60302836 0.61591643 0.70462233 0.82213771 0.62192625 0.5866906 0.56827313 0.58849585 0.58069175 0.54221219 PP1 1.06336188 1.01052952 1.0212152 1.0647037 1.03522992 0.92873585 1.17613816 0.97843343 0.98165512 1.11095464 1.00964737 0.99323165 Pravastatin sodium 0.64293665 0.64123571 0.6301201 0.63888258 0.62327784 0.62544912 0.62625533 0.62774003 0.60100442 0.65860766 0.65016621 0.65275067 Progesterone 1.04369307 0.96768427 0.93192762 0.97254044 0.99790269 0.92062312 0.98733234 0.91390377 0.9650138 0.9405356 0.91598439 0.89008427 PT-1 0.94002706 1.0270375 0.98048878 0.96514517 1.0424571 0.97997767 1.01753759 0.99772298 0.97604614 0.98601657 0.99746943 1.01691294 PTK787 0.95399016 0.83814991 0.81815755 0.7778191 0.83674347 0.90539247 0.82439202 0.77947348 0.83655882 0.83368504 0.83923191 0.83573586 Puromycin 0.66711885 0.66464353 0.65536642 0.74080569 0.60371429 0.66238183 0.66932803 0.68162388 0.66475236 0.68221903 0.64875782 0.70078182 R406 0.93251282 0.89121205 0.85878277 0.8413921 0.97592038 1.0221709 0.85376811 0.82103926 0.89145315 0.90362573 0.81790596 0.82405806 Raloxifene 0.92217594 0.99751538 0.94188219 0.9994393 0.88681412 1.00099146 0.95956856 0.92178673 0.94496775 0.9489454 0.97436905 0.92306542 Resveratrol 0.65126216 0.93437582 0.95926672 1.10500097 0.64145595 0.8797121 1.05824351 0.96975988 1.00494862 1.0499444 1.00993955 0.99181122 RHC 80267 0.92561197 0.98734468 0.99289483 0.97166276 0.97754449 0.96369851 0.97396344 1.01623189 0.95711553 1.00001585 0.99388623 1.00018966 Rofecoxib 0.78631634 0.9237318 1 1.02717972 0.91955012 0.93420017 1.1213876 0.97543865 1.0207392 1.02927351 1.01328719 1.12343824 Rosiglitazone 0.57086951 0.98873234 1.01813328 0.94371772 0.95609075 0.96409559 1.01502419 0.97212338 1.02512693 0.96129173 0.97868073 0.81511986 Rosuvastatin calcium 0.99384654 0.97599036 1.00392628 1.02989197 0.98342758 0.99688321 0.95762581 1.01007617 0.94826722 1.05543673 0.97543859 0.98966372 Salermide 0.71465534 0.73576683 0.80147916 0.8303957 0.71238661 0.74429536 0.82920355 0.7053054 0.83278871 0.75799936 0.78896075 0.82074654 SB-T-121-602 0.71055269 0.83433908 0.79444385 0.87921643 0.69056821 0.82532966 0.86798322 0.83398211 0.78012133 0.73401397 0.79462934 0.82837701 SB202190 0.87311536 0.97543865 0.94544148 0.97940755 0.97543865 0.98181719 0.96109855 0.84861785 0.89454156 0.93714947 0.97093225 0.97543865 SB203580 0.8450557 0.83871657 0.83952385 0.81965727 0.72327977 0.77821022 0.80222678 0.81374091 0.81250572 0.8056882 0.81896216 0.81046557 SB431542 0.81387347 0.77231091 0.78849858 0.87807912 0.75525451 0.82886708 0.83019471 0.80348426 0.82098854 0.79299748 0.81496561 0.80572081 Sertraline HCl 0.96640253 0.98970562 1.01620543 1.03148007 0.9759503 1.00179052 0.96762574 1.00593162 1.08079731 1.08067882 0.98953235 1.01320291 Sildenafil 1.06454802 0.96601927 0.98445374 0.90247661 1 0.92904323 0.96065718 0.95786422 0.92801338 0.92738473 0.91126668 1.00971544 Silvestrol 1.00704288 0.77887619 0.80394971 0.81246322 0.9106068 0.73593563 0.76370394 0.76064318 0.65987736 0.66000599 0.73352021 0.69917727 Simvastin 0.77417701 0.80816633 0.77583927 0.81496596 0.77483076 0.81018269 0.80359828 0.84102893 0.79898357 0.82971352 0.78916579 0.83882153 Sitagliptin phosphate 0.84967875 0.99019271 0.95224309 0.96646732 0.97432327 1.00074363 1.01632929 0.83556491 1.01836264 1.03093374 0.92715973 1.04150391 Sodium Fluoride 0.95371538 0.96639752 0.98104912 0.99987978 0.98639643 0.96144521 0.95648813 1.00183558 0.99094975 1.00161219 0.98003417 1.0113194 Solifenacin succinate 0.95348984 0.93602931 0.95369923 0.96151978 0.90556717 0.94889247 0.92876375 0.95630562 0.93948787 0.95873684 0.98605406 0.92107773 Sorafenib 0.69808215 0.5839383 0.59798348 0.6197859 0.66809112 0.68568772 0.60041726 0.57689047 0.60043848 0.57347715 0.60046726 0.54419285 SP600125 0.88685232 0.84321451 0.85829401 0.88682139 0.92019576 1.02527094 0.8513422 0.83823657 0.86891001 0.8465513 0.87698609 0.83074844 Staurosporin 0.82234329 0.82616884 0.89053547 0.82267147 0.71140504 0.93153387 0.84598053 0.81869221 0.7778272 0.77400941 0.87129825 0.83976167 SU11274 0.53880334 0.62628317 0.64706546 0.60595214 0.73733056 0.73992819 0.65214169 0.5939638 0.67479992 0.63982725 0.65208817 0.61022288 Sunitinib 0.87257242 0.66323787 0.6490171 0.6656518 0.76273513 0.75122476 0.65846688 0.6432426 0.60666025 0.64457899 0.6635341 0.57473975 Tadalafil 1.05907118 1.0819838 1.12806296 1.01841974 0.98949564 1.04513156 1.05977929 1.03051066 1.03953898 1.01827431 1.03540206 1.06875718 TAE684 1.03856277 0.84553057 0.91277736 0.87476355 0.92606223 0.85510939 0.84388822 0.88174427 0.87392986 0.84634662 0.87580496 0.82625973 TAK-700 0.86012644 0.94090015 0.99619323 0.88438952 0.9815464 0.91600192 0.92226344 0.92718911 0.98053592 0.9509216 0.91769338 0.90628225 Tamoxifen 1.06079841 0.98392743 1.00299871 0.92942727 1.03012061 0.96396595 1.0192169 0.96738601 0.95022774 0.92942488 0.97147793 0.97495043 Tandutinib 0.88311684 0.80733788 0.81384563 0.79225451 0.77166998 0.82368362 0.78746748 0.80881166 0.79265684 0.80756903 0.79704684 0.74845731 Telmisartan 0.86474264 0.99834675 0.99498892 1.02916634 0.92266709 0.92641079 1.05758417 1.00827849 1.06950831 1.0503999 1.04186916 1.04195726 Tenidap 1.17156506 1.06362748 1.05663502 1.01415765 1.11552608 1.03201079 1.02169478 0.98056394 1.03554904 1.04911494 1.06684077 1.08563912 Thalidomide 1.06561339 1.04707181 1.05138183 1.05981755 1.06341219 1.02394748 1.05377805 1.06977284 0.99430323 1.04333913 1.04876149 1.02703965 Thapsigargin 0.77500927 0.8086251 0.74313498 0.77483863 0.74237692 0.82236797 0.78736788 0.78741068 0.80826122 0.83275819 0.83408231 0.77052188 Thioguanine 0.69601232 0.66584301 0.64507294 0.69445717 0.7054671 0.71892333 0.6353814 0.67363065 0.64432007 0.67774206 0.68848103 0.65306294 Tirapazamine 1.00071752 1.01167262 0.96497953 0.97667551 0.96813983 0.96153551 0.94041449 0.93864959 1.00090885 0.96439886 0.95919806 0.937177 Tiron 1.00349188 0.98745465 1.02558541 1.02491593 1.00061464 1.00043523 1.00361216 0.97253054 1.04239762 0.96721607 0.98781335 1.0245899 Tivantinib 0.64563543 0.69685662 0.70237362 0.67613292 0.63882619 0.62617326 0.6645447 0.61973441 0.58998424 0.62717897 0.74247837 0.7294898 TOFA 1.01905084 1.02105916 1.00233519 1.02052116 0.99500388 1.00567877 1.01858425 0.98731166 0.99781609 1.08836031 1.01071405 0.98187757 Torcetrapib 0.97395808 0.94405454 0.9181338 0.97031641 0.9113903 0.89152473 1.00132501 0.96212071 0.87674671 0.83758289 0.96188319 0.89340556 Toremifene 1.13642645 0.90306586 1.01347482 1.03097391 0.88142169 0.94851685 1.04569864 0.97654647 0.97543859 0.99352062 1.01785529 1.06323469 Tozasertib 0.65866065 0.49099207 0.52372152 0.50642818 0.56455958 0.62048239 0.50922465 0.54172695 0.48747504 0.5081135 0.50457257 0.4654609 Triclosan 0.91168034 0.85283297 0.78993589 0.87684888 0.83033377 0.84535003 0.81727833 0.81350762 0.79218823 0.8648535 0.81502497 0.87155169 Troglitazone 0.77624893 0.91511154 0.80745292 0.8407129 0.85223311 0.83295768 0.85651845 0.83359522 0.83749694 0.86901176 0.87837732 0.86049634 TUG 424 0.97890353 0.99252754 1.0160141 0.99961466 0.99614465 0.9780342 1.01707542 1.00081968 1.0116092 1.01504755 0.9950636 0.99478126 Tunicamycin 0.91884536 1.02806878 1.00835979 0.97401553 0.91773349 0.97476542 0.90696746 0.96920401 0.94703805 0.95176119 0.99999988 0.95490783 UK 356618 0.93266457 0.9558509 0.9204461 0.978405 0.97867167 0.936692 0.90429932 0.87442893 0.88792408 0.95277774 0.9198885 0.9101786 UK 5099 0.71468925 0.97075385 0.97025704 0.80121356 0.9242456 0.8957628 0.99032176 0.93302894 0.96674263 0.99466538 0.95450711 1.03680289 Varespladib 1.01895308 0.99063045 0.99634802 1.03507936 1.00111842 1.01073813 0.99934125 1.02334249 1.03499687 0.92839694 1.00280118 1.01298547 Vincristine 1.00931907 0.95294333 0.96964663 0.91501832 0.96159589 0.87598532 0.92620713 0.90459603 0.94600993 0.87412006 0.84672678 0.9825139 Vismodegib 0.90302879 0.97543859 0.96675843 1.00486219 0.92425698 0.97144026 0.99666584 0.85363352 1.00352156 0.97656 0.94151801 0.94714355 Vorinostat 0.79773223 0.76687187 0.74583429 0.82691616 0.74890143 0.78451663 0.68754727 0.71440947 0.71707815 0.71986765 0.7224012 0.69647485 VX-702 1.07541144 0.97151363 0.95227969 0.97488898 1.04690766 0.93186158 0.97672164 0.93952256 0.95360225 0.94947165 0.9862355 0.94808549 YM155 0.51826471 0.59986961 0.60352707 0.57379764 0.49080208 0.64707273 0.5309267 0.57400024 0.63418919 0.58689672 0.59021753 0.60316044 YM750 1.04707468 0.98198038 0.97905594 1.03149009 1.04642403 0.96486622 0.94404715 1.01783621 0.97543865 0.96687609 1.02101445 Vandetanib 0.85322708 0.49910751 0.47239143 0.45071769 0.65414274 0.4102515 0.46909854 0.5051825 0.4928506 0.50270152 0.50332296 0.39119601 Zebularine 0.91024411 0.93482471 0.94895428 0.96434563 0.95378363 0.83322793 0.94158936 0.93386316 0.94488603 0.93311954 0.88880092 1.08596349 Zoledronate 1.08996606 0.98417693 1.03844965 0.94699824 1.04841924 1.03009152 1.00984693 1.01036966 1.07017136 0.97489071 1.0018028 1.01714909