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Home , Collagen loss

RegeneMax™ Health Support Advanced Generator ® Clinical Applications

»» Reduces Fine Lines and Wrinkles* »» Thickens and Strengthens Hair* »» Strengthens Nails*

»» Increases Hip Bone Mineral Density* Female Health »» Adds Flexibility to * »» Promotes Healthy Joints*

RegeneMax™ provides ch-OSA® (choline-stabilized orthosilicic acid), that helps naturally nourish your body’s beauty . Regular orthosilicic acid is highly unstable, leading it to form polymers. These polymers are too large for the human body to absorb. But the patented

“choline stabilization” technology in RegeneMax prevents the polymers Joint & Muscle Support from forming, ensuring optimal absorption. RegeneMax has been formulated with clinically proven ch-OSA for your assurance.*

RegeneMax Liquid is available in 1 ounces (30 mL) RegeneMax is available in 60 capsules and 120 capsules

Discussion Collagen is the body’s main structural . Collagen makes up Hospital in London, women already taking 1000 mg of calcium and 70% of and gives skin both strength and elasticity. Collagen 800 IU of vitamin D to which they added ch-OSA saw thigh bone forms 30% of bone and gives bones the flexibility they need to mineral density at the hip increase by 2.00% over the placebo as a withstand impact. The collagen fibers in bone are the binding sites result of an increase in actual bone formation, not just a decrease in [1] [7]

for calcium as well as all bone minerals. Collagen is the major loss. The procollagen marker P1NP (procollagen type-1 N-terminal Sports Nutrition component of fascia, , , and . But collagen propeptide) increased significantly after 12 months in women who production begins decreasing at age 18. By the age of 40, the took ch-OSA compared to women in the placebo group. P1NP is decrease is about 1% per year.[2] For women, the decline equates to known as the most sensitive marker for bone collagen formation a loss of 7% of skin thickness every 10 years. Following menopause, and an early marker of bone formation.[7] Animal studies support the the decline in thickness accelerates to as much as 1.13% annually, human clinical findings for ch-OSA with respect to collagen formation while skin elasticity degrades 0.55% per year.[3] Adequate collagen and bone mineral density.*[8-10] production correlates with healthy bones and strong hair and nails.*[2-4]

For years, orthosilicic acid was the focus of intense research because it was viewed as a potential collagen generator. As a result of that research, the molecular complex known as choline-stabilized orthosilicic acid (ch-OSA®) was created. Choline not only has the positively charged nitrogen atom that forms the vital bond with OSA, but according to leading collagen researchers, choline transports the orthosilicic acid into target cells where it activates the pathways involved in collagen production. Clinical trials also suggest that beyond its ability to generate collagen, ch-OSA promotes and formation—two proteins that assist in skin elasticity and hair tensile strength.*[5-7]

In a 20-week, randomized, double-blind, placebo-controlled study of 50 women with photo-damaged facial skin, oral intake of two ch-OSA capsules resulted in significantly improved skin, visco-elasticity properties, and a 30% reduction in micro-wrinkle depth compared to placebo.[5] In the same clinical trial, the women’s hair and nails showed significant improvements in strength. In a nine-month, randomized, double-blind, placebo-controlled trial with 48 healthy Caucasian women with fine hair (average age 43.3 years), ch-OSA (in daily capsules) significantly improved hair thickness and hair tensile strength.[6] In a 12-month clinical trial conducted at St. Thomas’ EXCLUSIVE • PATENTED *These statements have not been evaluated by the Food and Drug Administration. XYMOGEN® Exclusive Professional Formulas This product is not intended to diagnose, treat, cure, or prevent any disease. 800-647-6100 | www.xymogen.com Sports Nutrition Joint & Muscle Support Female Health Bone Health Support © XYMOGEN PROTECT FROMLIGHTANDMOISTURE. KEEP OUTOFTHEREACHCHILDREN. STOREAT 59-86°F(15-30°C). lactating. suspect amedicalcondition, aretakingprescriptiondrugs, orarepregnant CAUTIONS: nuts. DOES NOT CONTAIN: to fivedrops, twicedaily. Stir anddrinkimmediately. For Skin, Hair, Nails, andJointbenefits: Increasedose DIRECTIONS: RegeneMax preservatives. modified organisms(GMOs), artificialcolors, sweeteners, artificial or fish, shellfish, peanuts, treenuts, egg, ingredientsderivedfromgenetically DOES NOT CONTAIN: STORAGE: if tampersealisdamaged. should discusspotentialinteractionswiththeirhealthcarepractitioner. Donotuse Consult yourhealthcarepractitionerpriortouse. Individualstakingmedication healthcare practitioner. DIRECTIONS: RegeneMax MADE INBELGIUM ch-OSA U.S. PatentNumber Other Ingredients: ** DailyValue notestablished. Silicon (ascholine-stabilizedorthosilicicacid) Choline (ascholine-stabilizedorthosilicicacid) PerContainer:About120 Servings Size:5Drops(about0.25mL) Serving MADE INBELGIUM ch-OSA U.S. PatentNumber5,922,360andotherpatentspending. Other Ingredients: ** DailyValue notestablished. Silicon (ascholine-stabilizedorthosilicicacid) Choline (ascholine-stabilizedorthosilicicacid) Size:1Capsule Serving ® ® isaregisteredtrademarkof,andmanufacturedbyBioMineralsn.v., Belgium. isaregisteredtrademarkof,andmanufacturedbyBioMineralsn.v., Belgium. Storeinacool, placeoutofreachfromchildren. dry Consult your healthcare professional prior to use if you have or Consultyourhealthcareprofessionalpriortouseifyouhave ™ ™ For Bones: Onetimeperday, takesixdropsin2oz(1/4cup)liquid. Take twotimesperday, onecapsule orasdirectedbyyour LiquidSupplementFacts SupplementFacts Microcrystalline cellulose,HPMC(capsule),andpurifiedwater. Microcrystalline Glycerol,purifiedwater. 5,922,360andotherpatentspending. Wheat, gluten, corn, yeast, soy, products, animalordairy Wheat, gluten, soy, dairy, egg, fish/shellfishornuts/tree

Amount PerServing *These statements havenot been evaluatedby the FoodandDrug Administration.

This product isnot intendedto diagnose, treat, cure, orprevent anydisease. Amount PerServing All XYMOGEN 100 mg EXCLUSIVE EXCLUSIVE 5 mg

100 mg 5 mg ® Formulas MeetorExceedcGMP QualityStandards.

%Daily Value %Daily Value 18% ** ** ** • PATENTED 10. 9. 8. 7. 6. 5. 4. 3. 2. 1. References

femoral bone loss in aged ovariectomized rats supplementedwithcholine- ovariectomizedrats femoral bonelossinaged Calomme MR, GeusensP, DemeesterN, etal. Partial preventionoflong-term 2002; Zagreb, Croatia. Presented at: 29thEuropeanSymposium onCalcified Tissues; May25-29, orthosilicic acidonbonedensityinchicks. Calomme MR, Wijnen P, SindambiweJB, etal. Effectofcholine-stabilized Feb;56(2):153-165. [PMID: 9164661] inskinandcartilage. concentration the collagen orthosilicic acid. EffectontheSi, Ca, Mg, inserumand andPconcentrations Calomme MR, Vanden BergheDA. ofcalveswithstabilized Supplementation BMC MusculoskeletDisord inosteopenicfemales:of boneformation arandomized, placebo-controlledtrial. markers asanadjuncttocalcium/vitaminD3stimulates acid supplementation Spector TD, CalommeMR, Anderson SH, etal. Choline-stabilizedorthosilicic hair. inwomenwithfine orthosilicic acidonhairtensilestrengthandmorphology Wickett RR, Kossmann E, Barel A, etal. Effectoforal intakeofcholine-stabilized skin. stabilized orthosilicicacidonskin, nailsandhairinwomenwithphotodamaged Barel A, CalommeM, Timchenko A, etal. Effectoforalintakecholine- women.Japanese postmenopausal hypoestrogenismonskinelasticityandbonemineraldensityin Sumino H, S, Ichikawa Abe M, etal. (2004). and Effectsofaging June;13(2):60-4. [PMID: 17540135] Calleja-Agius J, Muscat-Baron Y, MP. Brincat Skinageing. Med Hypotheses. Shuster S. Osteoporosis, lossinskinandbone. hypothesisofcollagen aunitary Osteoporos Int. Viguet-Carrin S, GarneroP, DelmasPD. inbonestrength.The roleofcollagen 16604283] stabilized orthosilicicacid. Arch Dermatol Res Arch Dermatol Arch Dermatol Res. Arch Dermatol Additional referencesavailable uponrequest 2006;17:319-336. [PMID: 16341622] 2005;65(3):426-432. [PMID: 15951132] Endocr J . 2007Dec;299(10):499-505. [PMID: 17960402] 2005Oct;297(4):147-153. [PMID: 16205932] . 2008Jun11;9:85. [PMID: 18547426] Calcif Tissue Int Calcif Tissue . 2004 Apr;51(2):159-164. [PMID: 15118265]

. 2006, Apr;78(4): 227-232. [PMID: Calcif Tissue Int Calcif Tissue Biol Trace ElemRes Menopause Int . 2002, 70:292. Rev. 03/12/15 (RV) DRS-170 . 1997 . 2007