Cross-Tissue, Single-Cell Stromal Atlas Identifies Shared Pathological Fibroblast Phenotypes In
bioRxiv preprint doi: https://doi.org/10.1101/2021.01.11.426253; this version posted January 12, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in 2 four chronic inflammatory diseases 3 Ilya Korsunsky1-5,15, Kevin Wei1,15, Mathilde Pohin6,15, Edy Y. Kim7,8,15, Francesca Barone9,15, Joyce 4 B. Kang1-5, Matthias Friedrich6, Jason Turner9, Saba Nayar9,10, Benjamin A. Fisher9,10, Karim Raza9,, 5 Jennifer L. Marshall9, Adam P. Croft9, Lynette M. Sholl11, Marina Vivero11, Ivan O. Rosas12, Simon J. 6 Bowman9,10, Mark Coles6, Andreas P. Frei13, Kara Lassen13, Andrew Filer9,10, Fiona Powrie6,16,*, 7 Christopher D. Buckley9,10,16,*, Michael B. Brenner1,7,16,*, Soumya Raychaudhuri1-5,14,16,17,* 8 1Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital and Harvard Medical School, 9 Boston, MA, USA. 10 2Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, USA. 11 3Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA. 12 4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 13 5Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. 14 6Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, 15 University of Oxford, Oxford OX3 7FY, United Kingdom 16 7Harvard Medical School, Boston, MA 02115, USA 17 8Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 18 9Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, 19 University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2WD, UK.
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