Article A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 30UTR-Mediated Protein-Protein Interactions Graphical Abstract Authors Weirui Ma, Christine Mayr Correspondence
[email protected] In Brief ER-associated granules foster selective protein-protein interactions dictated by the nucleotide composition of the encoding mRNA. Highlights d TIS granules are membraneless organelles intertwined with the endoplasmic reticulum d TIS11B forms TIS granules that enrich or exclude specific mRNAs and proteins in vivo d TIS granules enable translation of mRNAs with AU-rich elements at an ER subdomain d Specific protein-protein interactions can only be formed in the TIS granule region Ma & Mayr, 2018, Cell 175, 1–15 November 29, 2018 ª 2018 Elsevier Inc. https://doi.org/10.1016/j.cell.2018.10.007 Please cite this article in press as: Ma and Mayr, A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 30UTR- Mediated Protein-Protein Interactions, Cell (2018), https://doi.org/10.1016/j.cell.2018.10.007 Article A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 30UTR-Mediated Protein-Protein Interactions Weirui Ma1 and Christine Mayr1,2,* 1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 2Lead Contact *Correspondence:
[email protected] https://doi.org/10.1016/j.cell.2018.10.007 SUMMARY cesses, including signaling and the addition of post-translational modifications (Li et al., 2012; Su et al., 2016). Approximately half of human genes generate mRNAs One type of membraneless organelles are RNA granules that with alternative 30 untranslated regions (30UTRs). contain mRNA transcripts packaged into ribonucleoprotein as- Through 30UTR-mediated protein-protein interac- semblies (Han et al., 2012).