Association of Pediatric Atopic Dermatitis and Cataract Development and Surgery

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Supplementary Online Content

Jeon HS, Choi M, Byun SJ, Hyon JY, Park KH, Park SJ. Association of pediatric atopic dermatitis and cataract development and surgery. JAMA Ophthamol. Published online June 7, 2018. doi:10.1001/jamaophthalmol.2018.2166

eTable 1. List of diagnostic codes used for defining subjects eTable 2. Drug lists used for defining atopic dermatitis eTable 3. Baseline characteristics of atopic dermatitis cohort and control group eTable 4. Cox analysis-derived hazard ratios (HRs) and 95% confidence intervals (CIs) of cataract development associated with atopic dermatitis (AD) and its covariates eTable 5. Cox analysis-derived hazard ratios (HRs) and 95% confidence intervals (CIs) of cataract surgery associated with atopic dermatitis (AD) and its covariates

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Downloaded From: https://jamanetwork.com/ on 09/24/2021 eTable 1. List of diagnostic codes used for defining subjects

Diagnoses Code numbers in KCD-6a Atopic dermatitis L20 Cataract H25, H26 Congenital malformation of eyes (anopthalmos, microphthalmos, and Q11 macrophthalmos) Congenital lens malformation Q12 Congenital malformation of anterior segment of eyes Q13 Congenital malformation of posterior segment of eyes Q14 Other congenital malformations of eyes Q15 Cataract surgery S5110, S5111, S5112, S5119 Asthma J45.0, J45.9 Allergic rhinitis J30.1, J30.2, J30.3, J30.4 aThe diagnosis was coded according to the Korean Classification of Disease, 6th edition (KCD-6, a version of the International Classification of Diseases, 10th edition, adapted for the Korean healthcare system).

Downloaded From: https://jamanetwork.com/ on 09/24/2021 eTable 2. Drug lists used for defining atopic dermatitis

Classification Drug azelastine bepotastine cetirizine/levocetirizine chlorpheniramine maleate clemastine desloratadine ebastine emedastine epinastine fexofenadine hydroxyzine Oral antihistamine ketotifen fumarate loratadine mequitazine mizolastine montelukast olopatadine oxatomide pemirolast piprinhydrinate pranlukast triprolidine zafirlukast amcinonide betamethasone valerate budesonide clobetasol propionate clobetasone butyrate desonide Topical corticosteroid desoxymethasone dexamethasone propionate diflorasone diacetate diflucortolone valerate fluocinolone acetonide fluocinonide

Downloaded From: https://jamanetwork.com/ on 09/24/2021 fluticasone propionate halcinonide hydrocortisone acetate Topical corticosteroid hydrocortisone butyrate (continued) methylprednisolone aceponate mometasone furoate prednicarbate prednisolone valeroacetate triamcinolone acetonide Topical calcineurin pimecrolimus inhibitor tacrolimus

Downloaded From: https://jamanetwork.com/ on 09/24/2021 eTable 3. Baseline characteristics of atopic dermatitis cohort and control group

AD cohort, No. (%) Control group, No. (%) Total No. 34,375 137,500 Age 0 11308 (32.90) 45232 (26.32) 1-4 14236 (41.41) 56944 (33.13)

5-9 3935 (11.45) 15740 (9.16)

10-14 2673 (7.78) 10704 (6.23) 15-19 2223 (6.47) 8880 (5.17)

Sex

Male 18216 (52.99) 72608 (52.81) Female 16159 (47.01) 64892 (47.19)

Residential region

Seoul, Incheon 9139 (26.59) 36565 (26.59) Gyeonggi, Gangwon 10083 (29.33) 40222 (29.25)

Gyeongsang 7580 (22.05) 30418 (22.12)

Chungcheong 3661 (10.65) 14596 (10.62) Jeola, Jeju 3912 (11.38) 15699 (11.42)

Household income

≦40% 7244 (21.07) 29020 (21.11) 50-80% 18567 (54.01) 74244 (54.00)

>90% 8564 (24.91) 34236 (24.90) Comorbidity Asthma 8477 (24.66) 47630 (34.64)

Allergic rhinitis 13352 (38.84) 71432 (51.95) AD = atopic dermatitis.

Downloaded From: https://jamanetwork.com/ on 09/24/2021 eTable 4. Cox analysis-derived hazard ratios (HRs) and 95% confidence intervals (CIs) of cataract development associated with atopic dermatitis (AD) and its covariates

Variables Events(n) HR (95% CI) P valuea AD No 137,500 1.00 Non-severe AD 30,641 0.69 (0.47 - 1.01) .06 Severe AD 3,734 1.95 (1.06 - 3.58) .03 Age 0 56,540 1 1-4 71,180 2.16 (1.45 - 3.22) <.001 5-9 19,675 2.29 (1.42 - 3.37) <.001 10-14 13,377 2.63 (1.60 - 4.33) <.001 15-19 11,103 3.99 (2.47 - 6.44) <.001 Male 90,824 1 Sex Female 81,051 3.99 (2.47 - 6.44) .93 Seoul, Incheon 45,704 1 Gyeonggi, Gangwon 50,305 1.67 (1.20 - 2.34) .003 Residential region Gyeongsang 37,998 0.98 (0.65 - 1.46) .91 Chungcheong 18,257 1.20 (0.75 - 1.94) .44 Jeola, Jeju 19,611 0.92 (0.55 - 1.52) .73 ≦40% 36,264 1 Household income 50-80% 92,811 0.79 (0.56 - 1.10) .16 >90% 42,800 1.31 (0.92 - 1.85) .13 Comorbidity No 115,768 1 Asthma Yes 56,107 1.24 (0.91 - 1.69) .17 No 87,091 1 Allergic rhinitis Yes 84,784 0.69 (0.52 - 0.92) .01 AD = atopic dermatitis; CI = confidence interval; HR = hazard ratio a Model was adjusted for AD, age, sex, residential region, household income and comorbidity in Cox proportional hazards regression.

Downloaded From: https://jamanetwork.com/ on 09/24/2021 eTable 5. Cox analysis-derived hazard ratios (HRs) and 95% confidence intervals (CIs) of cataract surgery associated with atopic dermatitis (AD) and its covariates

Variables Events(n) HR (95% CI) P valuea AD No 137,500 1.00 Non-severe AD 30,641 1.61 (0.77 - 3.35) .20 Severe AD 3,734 5.48 (1.90 - 15.79) .002 Age 0 56,540 1 1-4 71,180 0.73 (0.29 - 1.84) .50 5-9 19,675 0.91 (0.28 - 2.95) .86 10-14 13,377 2.76 (1.13 - 6.74) .02 15-19 11,103 2.05 (0.71 - 5.97) .18 Male 90,824 1 Sex Female 81,051 0.73 (0.39 - 1.38) .33 Seoul, Incheon 45,704 1 Gyeonggi, Gangwon 50,305 2.98 (0.98 - 9.15) .06 Residential region Gyeongsang 37,998 3.77 (1.23 - 11.58) .02 Chungcheong 18,257 1.84 (0.41 - 8.23) .42 Jeola, Jeju 19,611 3.80 (1.11 - 13.04) .03 ≦40% 36,264 1 Household income 50-80% 92,811 0.49 (0.24 - 1.02) .06 >90% 42,800 0.62 (0.27 - 1.41) .25 Comorbidity No 115,768 1 Asthma Yes 56,107 0.84 (0.34 - 2.09) .70 No 87,091 1 Allergic rhinitis Yes 84,784 0.57 (0.27 - 1.22) .14 AD = atopic dermatitis; CI = confidence interval; HR = hazard ratio. a Model was adjusted for AD, age, sex, residential region, household income and comorbidity in Cox proportional hazards regression.

Downloaded From: https://jamanetwork.com/ on 09/24/2021