Safety Data Sheet Phthalic Anhydride Flakes

Safety data sheet Issue Date 24-Aug-2021 Revision Date 24-Aug-2021 Version 2

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier Product Name Phthalic Anhydride flakes

Chemical Name CAS No EC No REACH Registration Number Phthalic anhydride 85-44-9 201-607-5 01-2119457017-41-0011

Pure substance/mixture Substance

1.2. Relevant identified uses of the substance or mixture and uses advised against Industrial Manufacture of substances. Formulation and (re)packing of substances and mixtures. Use as an intermediate and as a monomer for polymer formation.

Professional Laboratory chemicals.

Uses advised against Not identified.

1.3. Details of the supplier of the safety data sheet Manufacturer

Perstorp Oxo AB SE-444 84 Stenungsund Sweden Tel. +46 303 728600 Fax. +46 303 728607 www.perstorp.com

E-mail address [email protected]

1.4. Emergency telephone number Europe (+)1 760 476 3961 (contract no: 334101)

United Kingdom (+)44 8 08 189 0979 (contract no: 334101)

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Acute toxicity - Oral Category 4 - (H302) Skin corrosion/irritation Category 2 - (H315) Serious eye damage/eye irritation Category 1 - (H318) Respiratory sensitisation Caterory 1 - (H334) Skin sensitisation Caterory 1 - (H317) Specific target organ toxicity (single exposure) Category 3 - (H335)

2.2. Label elements Symbols/Pictograms

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Signal word Danger

Hazard statements H302 - Harmful if swallowed H315 - Causes skin irritation H317 - May cause an allergic skin reaction H318 - Causes serious eye damage H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 - May cause respiratory irritation

Precautionary Statements P261 - Avoid breathing dust/fume/gas/mist/vapours/spray P280 - Wear protective gloves/protective clothing/eye protection/face protection P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTER or doctor P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing P342 + P311 - If experiencing respiratory symptoms: Call a POISON CENTER or doctor

Contains: Phthalic anhydride

2.3. Other hazards This substance does not meet the criteria for classification as PBT or vPvB. Risk for dust explosion at concentrations >35 g/m3.

SECTION 3: Composition/information on ingredients

3.1 Substances Chemical Name EC No CAS No REACH Registration Weight-% Classification according to Number Regulation (EC) No. 1272/2008 [CLP] Phthalic anhydride 201-607-5 85-44-9 01-2119457017-41-0011 100 Acute Tox. 4 (H302) Skin Irrit. 2 (H315) Eye Dam. 1 (H318) Resp. Sens. 1 (H334) Skin Sens. 1 (H317) STOT SE 3 (H335)

Full text of H- and EUH-phrases: see section 16

Additional information No information available.

SECTION 4: First aid measures

4.1. Description of first aid measures

General advice Remove and isolate contaminated clothing and shoes.

Inhalation Remove to fresh air. If breathing is irregular or stopped, administer artificial respiration. If symptoms persist, call a doctor.

Skin contact Immediately flush skin with water and rinse skin with soap and water for at least 5-10 minutes. Use lukewarm water if possible. Remove contaminated clothing and shoes. Get medical attention if redness does not disappear.

Eye contact Important! Immediately rinse cautiously with tempered water for at least 15 minutes.

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Remove contact lenses, if present and easy to do. Continue rinsing. Get medical attention.

Ingestion Clean mouth with water and drink plenty of water afterwards. Get medical attention.

4.2. Most important symptoms and effects, both acute and delayed Inhalation: Inhalation of dust may cause respiratory irriation, allergy or asthma symptoms. Skin contact: Contact with skin and especially wet skin causes severe irritation. Prolonged exposure may as well cause an allergic dermatitis. Eye contact: Causes severe irritation with flood of tears and pain and strong redness and swelling of the eye. Risk of damage to the conjunctiva and cornea. Ingestion: May cause irritation of the mouth, throat, esophagus, and stomach including severe pain.

4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically

SECTION 5: Firefighting measures

5.1. Extinguishing media Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing media High volume water jet.

5.2. Special hazards arising from the substance or mixture Thermal decomposition can lead to release of irritating and toxic gases and vapours: Carbon monoxide (CO). Carbon dioxide (CO2).

5.3. Advice for firefighters Wear self-contained breathing apparatus and protective suit.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures Keep unprotected persons away. Wear tightly sealed goggles, protective gloves and if dusty conditions dust filter mask (P2). Avoid creating dust. In case of major spill contact the rescue services.

6.2. Environmental precautions Do not allow into any sewer, on the ground or into any body of water. Local authorities should be advised if significant spillages cannot be contained.

6.3. Methods and material for containment and cleaning up Methods for containment Cover with plastic sheet to prevent spreading. Methods for cleaning up Vacuum or sweep up material and place in a designated, labelled waste container. After cleaning, flush away traces with water.

6.4. Reference to other sections See Section 7,8,13 for more information.

SECTION 7: Handling and storage

7.1. Precautions for safe handling Before handling, investigate the hazards and risk of using this product at your work place. Persons with a history of skin sensitisation problems or asthma, allergies or chronic or recurrent respiratory disease should not handle this product. Ensure adequate ventilation. Wear personal protective equipment according to section 8 if risk of exposure. In case dust is created from flakes; dust may form an explosive mixture with air. Any unavoidable deposit of dust must be regularly removed. Use local exhaust ventilation. Keep away from sources of ignition - No smoking. Take precautionary measures against static discharges.

General Hygiene Considerations Take off all contaminated clothing and wash it before re-use. Wash hands before breaks and after work. Avoid contact with

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7.2. Conditions for safe storage, including any incompatibilities Keep containers tightly closed in a dry, cool and well-ventilated place.

Suitable container/equipment material Suitable container/equipment material: Keep/store only in original container.

7.3. Specific end use(s) For details, see the separate exposure scenario(s).

SECTION 8: Exposure controls/personal protection

8.1. Control parameters Exposure Limits Keep personal exposure levels below Derived No Effect Level (DNEL) and national exposure limit values (if existing). Chemical Name European Union United Kingdom Phthalic anhydride Not available TWA: 4 mg/m3 85-44-9 STEL: 12 mg/m3

Derived No Effect Level (DNEL) - worker Phthalic anhydride (85-44-9) Type Exposure route DNEL Remarks Chronic effects, systemic Inhalation 49.4 mg/m3 Acute effects, systemic Inhalation - No hazard identified Acute effects, local; Chronic effects, Inhalation - High hazard (no threshold local derived) Chronic effects, systemic Dermal 14 mg/kg bw/d Acute effects, systemic Dermal - No hazard identified Acute effects, local; Chronic effects, Dermal - High hazard (no threshold local derived) Local health effects Eye - Medium hazard (no threshold derived)

Derived No Effect Level (DNEL) - Consumer Phthalic anhydride (85-44-9) Type Exposure route DNEL Remarks Chronic effects, systemic Oral 5 mg/kg bw/d Chronic effects, systemic Dermal 5 mg/kg bw/d Chronic effects, systemic Inhalation 8.7 mg/m3 Acute effects, systemic Inhalation - No hazard identified Acute effects, local; Chronic effects, Inhalation - High hazard (no threshold local derived) Acute effects, systemic Dermal - No hazard identified Acute effects, local; Chronic effects, Dermal - High hazard (no threshold local derived) Local health effects Eye - Medium hazard (no threshold derived)

Phthalic anhydride (85-44-9) Environmental compartment Predicted No Effect Concentration Remarks (PNEC) Freshwater 1 mg/l Intermittent 5.6 mg/l Freshwater sediment 3.8 mg/kg dry weight Marine water 0.1 mg/l Marine sediment 0.38 mg/kg dry weight Impact on Sewage Treatment 10 mg/l

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Soil 0.173 mg/kg dry weight Air - No hazard identified Secondary poisoning - No bioaccumulation potential

8.2. Exposure controls

Appropriate engineering controls Technical measures: Use only in adequate ventilation. If user operations generate dust, fumes, gas, vapour or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits.

Individual protection measures, such as personal protective equipment Eye/face protection Tight sealing safety goggles. Hand Protection Wear protective nitrile rubber gloves. Ensure that the breakthrough time of the glove material is not exceeded. Refer to glove supplier for information on breakthrough time for specific gloves.

Skin and body protection Body protection must be chosen depending on activity and possible exposure, e.g. apron, chemical resistant boots, chemical-protection suit. Respiratory protection In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use self-contained respiratory protective device.

Environmental exposure controls Further information concerning special risk management measures: see annex of this safety data sheet (exposure scenarios).

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties Appearance Flakes white Odour Slight Odour threshold No data available

Property Value Remarks • Method pH Not determined Melting point / freezing point 131 °C OECD Test No. 102: Melting Point/ Melting Range Boiling point / boiling range 285 °C OECD Test No. 103: Boiling Point Flash point Not applicable Evaporation rate No information available Flammability (solid, gas) Not flammable Explosive limits Upper explosive limits 10.5 % Lower explosive limits 1.7 % Vapour pressure 0.0006 hPa @ 26.6 °C Vapour density Not applicable Relative density 1.49 20°C, ISO 1183-1 Water solubility 5.4 g/L @ 20 °C OECD Test No. 105: Water Solubility Solubility(ies) No information available Partition coefficient -0.6 @ 20 °C, OECD Test No. 117: Partition Coefficient (n-octanol/water), HPLC Method Autoignition temperature 580 °C Decomposition temperature Not applicable Kinematic viscosity Not applicable Dynamic viscosity Not applicable Explosive properties Not explosive. May form explosive mixtures with air Oxidising properties Not oxidising. Density No information available Bulk density No information available

9.2. Other information Particle Size Distribution. : 0.1 % (m/m) <100 µm.

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SECTION 10: Stability and reactivity

10.1. Reactivity There exists no specific test data for this product. For further information, see the subsequent subsections of this chapter.

10.2. Chemical stability The product is stable at normal conditions. However, the product reacts with the moisture in the air to form phthalic acid.

10.3. Possibility of hazardous reactions The product reacts with alkalis, alcohols, oxygen, oxidising agents, acids, nitrite and metallic oxides. Risk for dust explosion at concentrations >35 g/m3.

10.4. Conditions to avoid Avoid contact with humid air.

10.5. Incompatible materials Incompatible with strong oxidizing agents, strong acids and bases, nitric acid and sodium nitrate.

10.6. Hazardous decomposition products Thermal decomposition can lead to release of irritating and toxic gases and vapours: Carbon monoxide (CO) Carbon dioxide (CO2)

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Information on likely routes of exposure Inhalation. Dermal.

Symptoms related to the physical, chemical and toxicological characteristics

Most important symptoms and effects, both acute and delayed Inhalation: Inhalation of dust may cause respiratory irriation, allergy or asthma symptoms. Skin contact: Contact with skin and especially wet skin causes severe irritation. Prolonged exposure may as well cause an allergic dermatitis. Eye contact: Causes severe irritation with flood of tears and pain and strong redness and swelling of the eye. Risk of damage to the conjunctiva and cornea. Ingestion: May cause irritation of the mouth, throat, esophagus, and stomach including severe pain.

Numerical measures of toxicity

Acute toxicity Harmful if swallowed.

Phthalic anhydride (85-44-9) Method Species Exposure route Effective dose Remarks Not defined Rat Oral 1530 LD50 (lethal dose) mg/kg OECD Test No. 403: Acute Rat Inhalation >2.14 LC50 mg/l Aerosol Inhalation Toxicity Maximum attainable concentration

Skin corrosion/irritation Irritating to skin.

Phthalic anhydride (85-44-9) Method Species Exposure route Results: Not defined rabbit Dermal Slightly irritating.

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Serious eye damage/eye irritation Causes serious eye irritation. Risk of serious damage to eyes.

Phthalic anhydride (85-44-9) Method Species Exposure route Results: Not defined rabbit Eye Irritating to eyes

Respiratory or skin sensitisation May cause sensitisation by inhalation and skin contact.

Phthalic anhydride (85-44-9) Method Species Exposure route Results: OECD Test No. 406: Skin Guinea pig Skin Skin sensitization test (OECD Sensitisation 406) on guinea pigs: extremely sensitising OECD Test No. 429: Skin Mouse Skin Skin sensitisation test Local Sensitisation: Local Lymph Node Lymph Node Assay (OECD Assay 429): sensitising Not defined Guinea pig Inhalation Sensitising

Germ cell mutagenicity Not mutagenic.

Phthalic anhydride (85-44-9) Method Species Results: OECD Test No. 471: Bacterial Reverse in vitro Negative Mutation Test OECD Test No. 476: In vitro Mammalian Cell in vitro Negative Gene Mutation Test In vitro Mammalian Chromosome Aberration in vitro Negative Test OECD Test No. 474: Mammalian Erythrocyte in vivo, Mouse Negative Micronucleus Test

Carcinogenicity Animal studies have not shown any carcinogenic potential.

Phthalic anhydride (85-44-9) Method Species Exposure route Effective dose Remarks Not defined 104w Mouse male Oral 3570 NOAEL mg/kg bw/d Not defined 104w Mouse female Oral 1785 NOAEL mg/kg bw/d Not defined 105w Rat Oral 1000 NOAEL mg/kg bw/d

Reproductive toxicity There is no fertility study with phthalic anhydride available. No effects on reproductive organs were however observed in a oral carcinogenicity study in rats and mice.

Phthalic anhydride (85-44-9) Method Species Exposure route Effective dose Remarks Not defined 104w Mouse male Oral 3570 NOAEL mg/kg bw/d Results: Negative Not defined 104w Mouse female Oral 1785 NOAEL mg/kg bw/d Results: Negative Not defined 105w Rat Oral 1000 NOAEL mg/kg bw/d

STOT - single exposure Irritating to respiratory system

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Phthalic anhydride (85-44-9) Method Species Exposure route Effective dose Remarks Not defined human data Inhalation - Irritating to respiratory system

STOT - repeated exposure

Phthalic anhydride (85-44-9) Method Species Exposure route Effective dose Remarks Not defined 105w Rat Oral 500 NOAEL mg/kg bw/d

Aspiration hazard No hazard from product as supplied.

SECTION 12: Ecological information

12.1. Toxicity Low toxicity to aquatic organisms.

Phthalic anhydride (85-44-9) Method Species Exposure route Effective dose Exposure time Remarks OECD Test No. 210: Fish, Brachydanio rerio Freshwater 560 7d LC50 (lethal Early-Life Stage Toxicity concentration) mg/l Test Not defined Cyprinus carpio Freshwater >500 48h LC50 (lethal concentration) mg/l EPA 660/3-75-009 Daphnia magna Freshwater >640 48h EC50 (effective concentration) mg/l read-across from supporting substance (structural analogue) Regulation (EC) No. Scenedesmus Freshwater >=100 72h EC0 mg/l 440/2008, Annex, C.3 subspicatus OECD Test No. 210: Fish, Oncorhynchus Freshwater 10 60d NOEC mg/l Early-Life Stage Toxicity mykiss (rainbow Test trout) OECD Test No. 211: Daphnia magna Freshwater 16 21d NOEC mg/l Daphnia magna Reproduction Test

12.2. Persistence and degradability Readily biodegradable.

Phthalic anhydride (85-44-9) Method Value Exposure time Results: Hydrolysis as a Function of pH 0.7 - Half-life time minutes pH:4, 25°C Hydrolysis as a Function of pH 0.3 - Half-life time minutes pH 7, 25°C Hydrolysis as a Function of pH 0.02 - Half-life time minutes pH 9, 25°C OECD Test No. 301D: Ready 74% 30d Readily biodegradable Biodegradability: Closed Bottle Test (TG 301 D) OECD Test No. 301C: Ready 85% 14d Readily biodegradable Biodegradability: Modified MITI Test (I) (TG 301 C)

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12.3. Bioaccumulative potential Not potentially bioaccumulable.

Chemical Name Partition coefficient Bioconcentration factor (BCF) Phthalic anhydride -0.6 3.16

12.4. Mobility in soil The substance does not adsorb to suspended solids and sediment based upon the Koc which indicates a high mobility in soil.

Phthalic anhydride (85-44-9) Method Koc Remarks OECD 106 2-31

12.5. Results of PBT and vPvB assessment This substance does not meet the criteria for classification as PBT or vPvB

12.6. Other adverse effects Emissions to water lowers the pH. This may cause local damage to fish and aquatic organisms in the discharge area.

SECTION 13: Disposal considerations

13.1. Waste treatment methods Waste from residues/unused products The product is classified as hazardous waste and must be disposed of as such. Incinerate at a licensed installation.

Contaminated packaging Contaminated packaging materials must be disposed of in the same manner as the product.

Waste codes / waste designations according to EWC / AVV Waste from residues/unused products: 16 03 05*.

Other Information Waste codes should be assigned by the user based on the application for which the product was used.

SECTION 14: Transport information

ADR Road transport 14.1 UN number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated Subsidiary class - 14.4 Packing Group Not regulated 14.5 Environmental hazard Not applicable 14.6 Special precautions for user None

RID Rail transport 14.1 UN number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated Subsidiary hazard class - 14.4 Packing Group Not regulated 14.5 Environmental hazard Not applicable 14.6 Special precautions for user None

IMDG Sea transport 14.1 UN number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated 14.4 Packing Group Not regulated 14.5 Marine pollutant Not applicable 14.6 Special precautions for user None

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14.7 Transport in bulk according No information available to Annex II of MARPOL 73/78 and the IBC Code

IATA Air transport Not regulated 14.1 UN number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated 14.4 Packing Group Not regulated 14.5 Environmental hazard Not applicable 14.6 Special precautions for user None

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture International Regulations No information available.

European Union

Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work Take note of Directive 94/33/EC on the protection of young people at work Comply with 2014/34/EU concerning equipment and protective systems intended for use in potentially explosive atmospheres and, Directive 1999/92/EC regarding minimum requirements for improving the safety and health protection of workers potentially at risk from explosive atmospheres.

France

Chemical Name French RG number Phthalic anhydride RG 66,RG 66bis 85-44-9

Germany Water hazard class (WGK) slightly hazardous to water (WGK 1)

TA Luft (German Air Pollution Control Regulation) Chemical Name Type Class Phthalic anhydride - 85-44-9 5.2.5 I

15.2. Chemical safety assessment A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Key or legend to abbreviations and acronyms used in the safety data sheet

Full text of H-Statements referred to under section 3 H302 - Harmful if swallowed H315 - Causes skin irritation H318 - Causes serious eye damage H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled H317 - May cause an allergic skin reaction H335 - May cause respiratory irritation

Issue Date 24-Aug-2021

Revision Date 24-Aug-2021

Revision Note SDS sections updated: 2: PBT and vPvB assessment, 8, 9.

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This safety data sheet complies with the requirements of: Regulation (EC) No. 1907/2006, COMMISSION REGULATION (EU) No. 830/2015 of 20 May 2015.

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.

End of Safety Data Sheet

EUGB - BE

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Exposure scenario ES 1 - Manufacture of substances. Industrial ES 2 - Use as an intermediate. Industrial ES 3 - Use as a monomer for polymer formation. Industrial ES 4 - Formulation and (re)packing of substances and mixtures ES 5 - Laboratory chemicals. Professional Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006 [REACH]

Product Name ES 1 - Phthalic Anhydride flakes Chemical Name Phthalic anhydride CAS No 85-44-9 EC No 201-607-5 REACH registration number 01-2119457017-41-0011 Pure substance/mixture Substance Exposure scenario Section 1 - Title

Title ES1 - Manufacture of substances. Version 2 Product Name Phthalic Anhydride flakes Revision Date 23-Aug-2021

Section 2 - Operational conditions and risk management measures Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC1 - Manufacture of substances

Control of environmental exposure Title Contributing Scenario [CS] Environment Environmental release categories ERC1 - Manufacture of substances [ERC] Remarks Sewage treatment plant used Assumed domestic sewage treatment 2000 m3/d plant flow Removal efficiency (total) 87.3% Sludge treatment No application of sewage sludge to soil Can be landfilled or incinerated, when in compliance with local regulations Technical onsite conditions and Wet scrubber - gas removal or Incineration measures to reduce or limit discharges, air emissions Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure

Control of worker exposure Title Contributing Scenario [CS] 1 Process category(ies) PROC1 - Use in closed process, no likelihood of exposure; PROC2 - Use in closed, continuous process with occasional controlled exposure; PROC8b - Transfer of

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substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities; PROC9 - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Covers concentrations up to 100% Physical form of product Flakes Exposure duration Avoid carrying out operation for more than 8 h/d Use frequency 220 d/yr Technical conditions and measures Use in contained systems. Enclosed equipment. Ensure that the worker is in a to control dispersion from source separated (control) room with independent air supply PROC2, PROC8b, PROC9: Use towards the worker with local exhaust ventilation Conditions and measures related to Use in contained systems. Personal measures have to be applied in case of potential personal protection, hygiene and exposure only Sampling and Material transfers: Worst case assumption, Protective health evaluation clothing, Respiratory protection. See section 8 for more information. Organisational measures to prevent Ensure operatives are trained to minimise exposures. Assumes a good basic standard /limit releases, dispersion and of occupational hygiene is implemented. Pre-employment screening and appropriate exposure health surveillance. Indoor/Outdoor use Indoor

Section 3 - Exposure estimation

Environmental exposure

Environmental release category(ies) ERC1 - Manufacture of substances

Calculation method Used EUSES model Environmental compartment predicted exposure level Risk characterisation ratio (RCR) Freshwater 0.257 Freshwater sediment 0.316 Marine water 0.258 Marine sediment 0.312 Soil 0.015 Sewage treatment plant 0.253

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization The ECETOC TRA tool has been used to estimate workplace exposures unless otherwise indicated Title Exposure route Calculation method predicted exposure Risk characterisation level ratio (RCR) Contributing Scenario [CS] Worker - dermal, 0.003 PROC 1 long-term - systemic Contributing Scenario [CS] Worker - inhalative, 0.000 PROC 1 long-term - systemic Contributing Scenario [CS] Worker - combined, 0.034 PROC 1 long-term - systemic Contributing Scenario [CS] Worker - dermal, 0.014 PROC 2 long-term - systemic Contributing Scenario [CS] Worker - inhalative, 0.000 PROC 2 long-term - systemic Contributing Scenario [CS] Worker - combined, 0.014 PROC 2 long-term - systemic Contributing Scenario [CS] Worker - dermal, 0.069 PROC 8b long-term - systemic Contributing Scenario [CS] Worker - inhalative, 0.000 PROC 8b long-term - systemic Contributing Scenario [CS] Worker - combined, 0.069 PROC 8b long-term - systemic

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Contributing Scenario [CS] Worker - dermal, 0.069 PROC 9 long-term - systemic Contributing Scenario [CS] Worker - inhalative, 0.000 PROC 9 long-term - systemic Contributing Scenario [CS] Worker - combined, 0.069 PROC 9 long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario

Predicted exposures are not expected to exceed the applicable exposure limits (given in section 8 of the SDS) when the operational conditions/risk management measures given in section 2 are implemented. Where other risk management measures/operational conditions are adopted, then users should ensure that risks are managed to at least equivalent levels. Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be necessary to define appropriate site-specific risk management measures.

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Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006 [REACH]

Product Name ES 2 - Phthalic Anhydride flakes Chemical Name Phthalic anhydride CAS No 85-44-9 EC No 201-607-5 REACH registration number 01-2119457017-41-0011 Pure substance/mixture Substance Exposure scenario Section 1 - Title

Title ES2 - Use as an intermediate. Industrial. Version 2 Product Name Phthalic Anhydride flakes Revision Date 23-Aug-2021 Sector(s) of use SU8 - Manufacture of bulk, large scale chemicals (including petroleum products) SU9 - Manufacture of fine chemicals

Section 2 - Operational conditions and risk management measures Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates)

Control of environmental exposure Title Contributing Scenario [CS] Environment Environmental release categories ERC6a - Industrial use resulting in manufacture of another substance (use of [ERC] intermediates) Maximum daily site tonnage max 360 days/year, total: 579 500 tonnes/year Remarks Sewage treatment plant used Assumed domestic sewage treatment 2000 m3/day plant flow Removal efficiency (total) 87.3% Sludge treatment No application of sewage sludge to soil Can be landfilled or incinerated, when in compliance with local regulations Technical onsite conditions and Wet scrubber - gas removal or Incineration measures to reduce or limit discharges, air emissions Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure

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Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Use in closed process Provide a good standard of general ventilation (not less than 3 to to control dispersion from source 5 air changes per hour) towards the worker Conditions and measures related to See section 8 for more information personal protection, hygiene and health evaluation Indoor/Outdoor use Covers indoor and outdoor use Operational conditions <= 40 °C

Title Contributing Scenario [CS] 2 Process category(ies) PROC2 - Use in closed, continuous process with occasional controlled exposure; Outdoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Use in closed, continuous process with occasional controlled exposure. to control dispersion from source towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training. Use eye protection according to EN 166, designed to protect against dusts. health evaluation Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Outdoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 3 Process category(ies) PROC2 - Use in closed, continuous process with occasional controlled exposure; Indoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Use in closed, continuous process with occasional controlled exposure. Provide a good to control dispersion from source standard of general ventilation (not less than 3 to 5 air changes per hour) Local exhaust towards the worker ventilation - efficiency of at least 95% Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against dusts Wear health evaluation full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 4 Process category(ies) PROC3 - Use in closed batch process (synthesis or formulation). Outdoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training. Use eye protection according to EN 166, designed to protect against dusts health evaluation Wear full chemical protective clothing. See section 8 for more information. Indoor/Outdoor use Outdoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 5 Process category(ies) PROC3 - Use in closed batch process (synthesis or formulation); Indoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Local exhaust ventilation - efficiency of at least 90%. Provide a good standard of general to control dispersion from source ventilation (not less than 3 to 5 air changes per hour) towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity

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personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against dusts Wear health evaluation full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 6 Process category(ies) PROC8a - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non dedicated facilities; Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Technical conditions and measures Local exhaust ventilation - efficiency of at least 90% Provide a good standard of general to control dispersion from source ventilation (not less than 3 to 5 air changes per hour) towards the worker Conditions and measures related to Respiratory protection: APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training Use eye protection according to EN 166, health evaluation designed to protect against dusts Wear full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 7 Process category(ies) PROC8b - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Technical conditions and measures Local exhaust ventilation - efficiency of at least 95%. Provide a good standard of general to control dispersion from source ventilation (not less than 3 to 5 air changes per hour) towards the worker Conditions and measures related to Respiratory protection APF 20 Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training Use eye protection according to EN 166, health evaluation designed to protect against dusts Wear full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 8 Process category(ies) PROC9 - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 1 h/d Conditions and measures related to Respiratory protection APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against dusts Wear full chemical protective clothing. See section 8 for more information. Indoor/Outdoor use Outdoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 9 Process category(ies) PROC15 - Use as laboratory reagent Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against dusts Wear health evaluation full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor

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Use in room with a volume of ≥ 300 m3 minimum Operational conditions <= 40 °C

Title Contributing Scenario [CS] 10 Process category(ies) PROC28 - Manual maintenance (cleaning and repair) of machinery Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour) towards the worker Conditions and measures related to Respiratory protection APF 20 Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training Use eye protection according to EN 166, health evaluation designed to protect against dusts Wear full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Section 3 - Exposure estimation

Environmental exposure

Environmental release category(ies) ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates)

Calculation method Used EUSES model Environmental compartment predicted exposure level Risk characterisation ratio (RCR) Freshwater 0.216 Freshwater sediment 0.266 Marine water 0.216 Marine sediment 0.266 Soil 0.026 Sewage treatment plant 0.253

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization The ECETOC TRA tool has been used to estimate workplace exposures unless otherwise indicated Title Exposure route Calculation method predicted exposure Risk characterisation level ratio (RCR) Contributing Scenario [CS] 1 Worker - dermal, <0.01 long-term - systemic; Worker - inhalative, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 2. Worker - dermal, <0.01 Outdoor use long-term - systemic Contributing Scenario [CS] 2. Worker - inhalative, 0.014 Outdoor use long-term - systemic Contributing Scenario [CS] 2. Worker - combined, 0.019 Outdoor use long-term - systemic Contributing Scenario [CS] 3. Worker - dermal, <0.01 Indoor use long-term - systemic Worker - inhalative,

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long-term - systemic, Worker - combined, long-term - systemic Contributing Scenario [CS] 3. Worker - inhalative, <0.01 Indoor use long-term - systemic Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 4; Worker - inhalative, <0.01 Outdoor use long-term - systemic Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 5; Worker - inhalative, <0.01 Indoor use long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 6 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 6 Worker - dermal, 0.029 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 7 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 7 Worker - dermal, 0.029 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 8 Worker - inhalative, <0.01 long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 9 Worker - inhalative, <0.01 long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 10 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 10 Worker - dermal, 0.049 long-term - systemic; Worker - combined, long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario

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Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006 [REACH]

Product Name ES 3 - Phthalic Anhydride flakes Chemical Name Phthalic anhydride CAS No 85-44-9 EC No 201-607-5 REACH registration number 01-2119457017-41-0011 Pure substance/mixture Substance Exposure scenario Section 1 - Title

Title ES3 - Use as a monomer for polymer formation. Industrial. Version 2 Product Name Phthalic Anhydride flakes Revision Date 23-Aug-2021

Section 2 - Operational conditions and risk management measures Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC6c - Industrial use of monomers for manufacture of thermoplastics ERC6d - Industrial use of process regulators for polymerisation processes in production of resins, rubbers, polymers

Control of environmental exposure Title Contributing Scenario [CS] Environment Environmental release categories ERC6c - Industrial use of monomers for manufacture of thermoplastics ERC6d - [ERC] Industrial use of process regulators for polymerisation processes in production of resins, rubbers, polymers Maximum daily site tonnage max 360 days/year, total: 37 500 tonnes/year Remarks Sewage treatment plant used Assumed domestic sewage treatment 2000 m3/day plant flow Removal efficiency (total) 87.3% Sludge treatment No application of sewage sludge to soil Can be landfilled or incinerated, when in compliance with local regulations Technical onsite conditions and Wet scrubber - gas removal or Incineration measures to reduce or limit discharges, air emissions Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure

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Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Use in closed process. Provide a good standard of general ventilation (not less than 3 to to control dispersion from source 5 air changes per hour). towards the worker Conditions and measures related to See section 8 for more information personal protection, hygiene and health evaluation Indoor/Outdoor use Covers indoor and outdoor use Operational conditions <= 40 °C

Title Contributing Scenario [CS] 2 Process category(ies) PROC2 - Use in closed, continuous process with occasional controlled exposure; Outdoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Use in closed batch process with occasional controlled exposure. Provide a good to control dispersion from source standard of general ventilation (not less than 3 to 5 air changes per hour) towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training. Use eye protection according to EN 166, designed to protect against dusts. health evaluation Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Outdoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 3 Process category(ies) PROC2 - Use in closed, continuous process with occasional controlled exposure; Indoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Use in closed batch process with occasional controlled exposure Provide a good to control dispersion from source standard of general ventilation (not less than 3 to 5 air changes per hour) Local exhaust towards the worker ventilation - efficiency of at least 90% Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training. Use eye protection according to EN 166, designed to protect against dusts. health evaluation Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 4 Process category(ies) PROC3 - Use in closed batch process (synthesis or formulation); Outdoor Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against dusts Wear health evaluation full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

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Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against dusts Wear health evaluation full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 6 Process category(ies) PROC8a - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non dedicated facilities Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Technical conditions and measures Local exhaust ventilation - efficiency of at least 90%. Provide a good standard of general to control dispersion from source ventilation (not less than 3 to 5 air changes per hour). towards the worker Conditions and measures related to Respiratory protection: APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against dusts. Wear full chemical protective clothing. See section 8 for more information. Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 7 Process category(ies) PROC8b - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Technical conditions and measures Local exhaust ventilation - efficiency of at least 95%. Provide a good standard of general to control dispersion from source ventilation (not less than 3 to 5 air changes per hour). towards the worker Conditions and measures related to Respiratory protection APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against dusts. Wear full chemical protective clothing. See section 8 for more information. Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 8 Process category(ies) PROC9 - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 1 h/d Conditions and measures related to Respiratory protection: APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against dusts. Wear full chemical protective clothing. See section 8 for more information. Indoor/Outdoor use Outdoor Operational conditions <= 40 °C

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Indoor/Outdoor use Indoor Use in room with a volume of 300 m3 minimum Operational conditions <= 40 °C

Title Contributing Scenario [CS] 10 Process category(ies) PROC28 - Manual maintenance (cleaning and repair) of machinery Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour) towards the worker Conditions and measures related to Respiratory protection: APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against dusts. Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Section 3 - Exposure estimation

Environmental exposure

Calculation method Used EUSES model Environmental compartment predicted exposure level Risk characterisation ratio (RCR) Freshwater ERC6C 0.253 Freshwater sediment ERC6C 0.314 Marine water ERC6C 0.253 Marine sediment ERC6C 0.315 Soil ERC6C 0.352 Sewage treatment plant ERC6C 0.253 Freshwater ERC6D 0.39 Freshwater sediment ERC6D 0.489 Marine water ERC6D 0.39 Marine sediment ERC6D 0.484 Soil ERC6D 0.533 Sewage treatment plant ERC6D 0.39

Control of worker exposure

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Contributing Scenario [CS] 2; Worker - dermal, <0.01 Outdoor use long-term - systemic Contributing Scenario [CS] 3; Worker - inhalative, <0.01 Indoor use long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 4; Worker - inhalative, <0.01 Outdoor use long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 5; Worker - inhalative, <0.01 Indoor use long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 6 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 6 Worker - combined, 0.029 long-term - systemic; Worker - dermal, long-term - systemic Contributing Scenario [CS] 7 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 7 Worker - dermal, 0.029 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 8 Worker - inhalative, <0.01 long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 9 Worker - inhalative, <0.01 long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 10 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 10 Worker - dermal, 0.049 long-term - systemic; Worker - combined, long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario

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Page 24 / 31 Safety data sheet Issue Date 09-Jul-2021 Revision Date 23-Aug-2021 Version 2

Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006 [REACH]

Product Name ES 4 - Phthalic Anhydride flakes Chemical Name Phthalic anhydride CAS No 85-44-9 EC No 201-607-5 REACH registration number 01-2119457017-41-0011 Pure substance/mixture Substance Exposure scenario Section 1 - Title

Title ES4 - Formulation and (re)packing of substances and mixtures. Version 2 Product Name Phthalic Anhydride flakes Revision Date 23-Aug-2021

Section 2 - Operational conditions and risk management measures Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC2 - Formulation of preparations (mixtures)

Control of environmental exposure Title Contributing Scenario [CS] Environment Environmental release categories ERC2 - Formulation of preparations (mixtures) [ERC] Maximum daily site tonnage max 360 days/year, total: 47 500 tonnes/year Remarks Sewage treatment plant used Assumed domestic sewage treatment 2000 m3/d plant flow Removal efficiency (total) 87.3% Sludge treatment No application of sewage sludge to soil Can be landfilled or incinerated, when in compliance with local regulations Technical onsite conditions and Wet scrubber - gas removal or Incineration measures to reduce or limit discharges, air emissions Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure

Control of worker exposure Title Contributing Scenario [CS] 1 Process category(ies) PROC1 - Use in closed process, no likelihood of exposure Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per

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to control dispersion from source hour) towards the worker Conditions and measures related to See section 8 for more information personal protection, hygiene and health evaluation Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 2 Process category(ies) PROC2 - Use in closed, continuous process with occasional controlled exposure Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour). Local exhaust ventilation: Efficiency of at least 90% towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training. Use eye protection according to EN 166, designed to protect against powders health evaluation and dusts. Wear full chemical protective clothing. See section 8 for more information. Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 3 Process category(ies) PROC3 - Use in closed batch process (synthesis or formulation) Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour). Local exhaust ventilation: Efficiency of at least 90% towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against powders health evaluation and dusts Wear full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 4 Process category(ies) PROC8a - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non dedicated facilities Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour). Local exhaust ventilation Efficiency of at least 90% towards the worker Conditions and measures related to Respiratory protection: APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against powders and dusts. Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 5 Process category(ies) PROC8b - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per

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to control dispersion from source hour) Local exhaust ventilation Efficiency of at least 95% towards the worker Conditions and measures related to Respiratory protection: APF 20. Wear chemically resistant gloves (tested to EN374) in personal protection, hygiene and combination with specific activity training. Use eye protection according to EN 166, health evaluation designed to protect against powders and dusts. See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 6 Process category(ies) PROC8b - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour) Local exhaust ventilation Efficiency of at least 95% towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training. Use eye protection according to EN 166, designed to protect against powders health evaluation and dusts. Wear full chemical protective clothing See section 8 for more information. Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 7 Process category(ies) PROC9 - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour). Local exhaust ventilation: Efficiency of at least 90%. towards the worker Conditions and measures related to Wear chemically resistant gloves (tested to EN374) in combination with specific activity personal protection, hygiene and training Use eye protection according to EN 166, designed to protect against powders health evaluation and dusts Wear full chemical protective clothing See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 8 Process category(ies) PROC9 - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 1 h/d Conditions and measures related to Respiratory protection: APF 20. Use eye protection according to EN 166, designed to personal protection, hygiene and protect against powders and dusts. Wear full chemical protective clothing. See section 8 health evaluation for more information. Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Title Contributing Scenario [CS] 9 Process category(ies) PROC15 - Use as laboratory reagent Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/d Conditions and measures related to Use eye protection according to EN 166, designed to protect against powders and personal protection, hygiene and dusts. Wear chemically resistant gloves (tested to EN374) in combination with specific health evaluation activity training. Wear full chemical protective clothing. See section 8 for more information

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Indoor/Outdoor use Indoor Use in room with a volume of ≥ 300 m3 minimum Operational conditions <= 40 °C

Title Contributing Scenario [CS] 10 Process category(ies) PROC28 - Manual maintenance (cleaning and repair) of machinery Covers concentrations up to <=100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 8 h/d Technical conditions and measures Provide a good standard of general ventilation (not less than 3 to 5 air changes per to control dispersion from source hour) towards the worker Conditions and measures related to Respiratory protection: APF 20. Use eye protection according to EN 166, designed to personal protection, hygiene and protect against powders and dusts. Wear chemically resistant gloves (tested to EN374) health evaluation in combination with specific activity training. Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Indoor Operational conditions <= 40 °C

Section 3 - Exposure estimation

Environmental exposure

Environmental release category(ies) ERC2 - Formulation of preparations (mixtures)

Calculation method Used EUSES model Environmental compartment predicted exposure level Risk characterisation ratio (RCR) Freshwater 0.253 Freshwater sediment 0.308 Marine water 0.253 Marine sediment 0.303 Soil 0.36 Sewage treatment plant 0.253

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization The ECETOC TRA tool has been used to estimate workplace exposures unless otherwise indicated Title Exposure route Calculation method predicted exposure Risk characterisation level ratio (RCR) Contributing Scenario [CS] 1 Worker - dermal, <0.01 long-term - systemic; Worker - inhalative, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 2 Worker - dermal, <0.01 long-term - systemic; Worker - inhalative, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 3 Worker - inhalative, <0.01 long-term - systemic; Worker - dermal, long-term - systemic;

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Worker - combined, long-term - systemic Contributing Scenario [CS] 4 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 4 Worker - dermal, 0.029 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 5 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 5 Worker - dermal, 0.029 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 6 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 6 Worker - dermal, 0.049 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 7 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 7 Worker - dermal, 0.025 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 8 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 8 Worker - dermal, 0.098 long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 9 Worker - inhalative, <0.01 long-term - systemic; Worker - dermal, long-term - systemic; Worker - combined, long-term - systemic Contributing Scenario [CS] 10 Worker - inhalative, <0.01 long-term - systemic Contributing Scenario [CS] 10 Worker - dermal, 0.049 long-term - systemic; Worker - combined, long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario

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Page 29 / 31 Safety data sheet Issue Date No data available Revision Date 23-Aug-2021 Version 2

Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006 [REACH]

Product Name ES 5 - Phthalic Anhydride flakes Chemical Name Phthalic anhydride CAS No 85-44-9 EC No 201-607-5 REACH registration number 01-2119457017-41-0011 Pure substance/mixture Substance Exposure scenario Section 1 - Title

Title ES5 - Laboratory chemicals. Professional. Version 2 Product Name Phthalic Anhydride flakes Revision Date 23-Aug-2021 Sector(s) of use SU0 - Other Product category(ies) PC21 - Laboratory chemicals

Section 2 - Operational conditions and risk management measures Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC8a - Wide dispersive indoor use of processing aids in open systems ERC8b - Wide dispersive indoor use of reactive substances in open systems

Control of environmental exposure Title Contributing Scenario [CS] Environment Environmental release categories ERC8a - Wide dispersive indoor use of processing aids in open systems ERC8b - Wide [ERC] dispersive indoor use of reactive substances in open systems Waste management See Section 13 for additional waste treatment information

Section 2.2 - Control of worker exposure

Control of worker exposure Title Contributing Scenario [CS] 1 Process category(ies) PROC15 - Use as laboratory reagent Covers concentrations up to 100% Physical form of product Flakes Level of dustiness Low Exposure duration Avoid carrying out operation for more than 4 h/day Conditions and measures related to Use eye protection according to EN 166, designed to protect against dusts. Wear personal protection, hygiene and chemically resistant gloves (tested to EN374) in combination with 'basic' employee health evaluation training. Wear full chemical protective clothing. See section 8 for more information Indoor/Outdoor use Indoor Use in room with a volume of ≥ 300 m3 minimum Operational conditions <= 40 °C

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Section 3 - Exposure estimation

Environmental exposure

Environmental release category(ies) ERC8a - Wide dispersive indoor use of processing aids in open systems ERC8b - Wide dispersive indoor use of reactive substances in open systems

Calculation method Used EUSES model Environmental compartment predicted exposure level Risk characterisation ratio (RCR) Freshwater ERC8a 0.002 Freshwater sediment ERC8a 0.002 Marine water ERC8a 0.013 Marine sediment ERC8a 0.0013 Soil ERC8a 0.622 Sewage treatment plant ERC8a 0.439 Freshwater ERC8b 0.000 Freshwater sediment ERC8b 0.000 Marine water ERC8b 0.000 Marine sediment ERC8b 0.000 Soil ERC8b 0.026 Sewage treatment plant ERC8b 0.015

Control of worker exposure

Section 4 - Guidance to check compliance with the exposure scenario

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