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Respiratory Function Measurements in Infants Measurement Conditions

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Respiratory Function Measurements in Infants Measurement Conditions Respiratory Function Measurements in infants Measurement Conditions CONTENTS Resuscitation Equipment lntroduetion Each laboratory or measurement area should have oxygen and Labomtory Conditions resuscitation equipment available, which must be suitable for the Resuscitation equrpmenl infants being tested. A self-inflating resuscitation bag with oxy- Prepamtion of the Entarrt gen, as we![ as a frrnct~oningsuction apparatus and suction Cmheel length catheters, should be omhand. An emergency cart or kii must k feeding immediaIy available. At least one person must be present who Posture is skilled in airway management and pediatric basic life support. Sedation Medical back-up who are skilled in pediatric advanced life sup- Chlorafi Qeri~tiveS Phamacokinetics port or equivalent should be Miableduring all studies on sedated Side effects infants, or whenever measurements on unsedated infants irwolve Repeated sedation equipment (such as a mask or pneumotachograph) at the airway Midmlam Opening. A direct contact line to the pediatric intensive =re unit Assessment and Monitoring of the Sedated Infant would be advantageous. Trained staff should be n attendance Sleep State throughout all measurements. Development of sleep states organization In the intensive or critical care environment a second person Monitoring d sleep states must be present to monitor the infant. Influence of sleep state on functionat residual capacity Any apparatus that comes into contact with the infant must be Summary Recommendations thoroughly sterilized or disinfected been=. MQ& mmmer- cially available equipment currently in use is difficutt €o disman- THIS OFFlCldl STATEMENTOf THE AMERICANTHORACIC tle and sterilize. Appropriate facitfitis and mummust be es- SOCtEn AND THE EUROPEANRESPIRATORY SOCIETY WE tabllshed to ensure there is no compromise on cleaning and ADOPTEDBY THE AnBOARD OF DIRECTORS(FEBRUARY sterilization of equipment used for infant lung function tests. To control the influence of environmental temperature on re- 1995) AND f HE ERS EXECUTIVECOMMITTEE (MAY 1994). spiratory pattern, room tempemre should be maintained Mn 2049C Advanced reom&! intensbeare and imprwed SUMofprema- (air-oonditioning may be required). Even asmalt increase turely bwn infants with ~ryjngdegrees of chronic Zung disease in mytwnperzrture may induce a change in respiratwy frequency (1,2). have focused attention on the usefulness of pulmonary function and pattern Menstudying young infants (especialty those testing in infants and young children. Pulmonary function tests who are preterm), rt is partlcdarly important that the laboratory at pFTs) are usefut in research and clinical practice. Ciassical PFT is maintained an admuate temperature ta prevent bcdy & techniques have Wnmodified and miniaturized for infants, and ing. Whenever possible, the local environment shwld encoumge and innovativemethods have been developed. Whateverttre PFT used, skpby use of dimmed lighting noise reduction. Infants shwid standardimtion of measurement conditi'ons is crucial for the in- never be left unattended, and when measurementsare to k per- formed on bench-top type surface, side rails must be fitted. hnYs safety, accuracy of the test, and repraducibillty of the data, a especialjy for longitudinat studies and multicenter trials Standardbation of measurement conditions must addmbath fabratory anditions and the infads mewith respect to such PREPARATlON OF MEINFANT factors as feeding. posture, sedation, and sleep state. For most purpses, lung function measurements shwld not be made within 3 wk of an upper ~piratorytract infection, unless LABORATORY CONDITIONS specifically wishing ta study this period. Airway resistme and all related parameters anchange sfgnficantly due to mu& Achiwernent of satisfactory results depends on careful handling swelling and increased secretions (3). and minimal disturbance of the infant. Opportunities for repeat- Regardless of which tests are to be performed, the ptepara- faubmp jOg Or ddaylng measurementsshoufd tion of the infant for lung function tern is genedly similar. ing testing are usually very limited, and it IS therefore advisable Normal wlues for all mpiratory parameters are usually relared to check all equipment before each test. All equipment should to body weight, length, or both (4). Afl infants should therefore be regularly tested for patient safely. be weighed unclothed and their length measured at the time of test, or-a! the neampcssible time the ease of sick ventilated This Sraternent was dweloped by C. Caultier, M. L Rethr, C kardsmore, S. bglad,and L M~~~~ incmjmdon a $te~x/~~Working G~~~ infants. It is importantthat this is accurate to within 0.5 m. A pe on 5tandardiratiOn of Infant Pulmonary Function Tests. eke infant bdiometer and scales should be available in all centew This paper is being aopublished and mghtedwith the Europwn Respim- undertaking such measuremen&. tory ~ovmrrl. Some forms of monitoring, mast conveniently a pub? oximeter, ~m 1 RespirCritkMd Vod 151.pp2058-rOw. 1495 should ke used during all measurements, since wen heahhy in- ATSIERS Statement fants may respond adversely to trigeminal stimulation or airway The most important consideration in all situations is that. un- oedusion (5-7). less asessing the effect of positioning itself, serial rneasumnts The infanfs clothing shwM not restrict respiratory rnovemerrts in any one infant should be made with the baby in the same po- . in any way and should be loosened or rernwed as necessary. sition. Mest refwence values have been compiled using data mflected Crown-heel length from infants in thesupine or lateral position, and this must be con- ARhwgh it is fundamental to the establishment and use of refer- sidered when assessing resutts from infants measured in d-ffer- ence values and to the interpretationaf pulmonary function results ent positions. In addition to gross trunk position, neck position during disease, measuring of an infant's kleng is rarely described may also influence resuits, and a neutral position should be in detail. An acceptable method (8) is therefore described below. adopted (avoiding Rexion, rotation, or overextension) (20). An ex- Small infants tend to be disturbed by being straightened for ception to this appears To be during the forced expiration maneu- length rneasuremerrts and, consequenfly such measurements are ver, when higher flows may be obtained by extending the neck, usually performed once all lung funetFon tests are completed. A possibly as a result of stabilization of the upper airway (21). In ad- small cotton sheet is placed on the stadiometer before lying the dition, slight alterations in neck position may resolve problems infant on top, as it is hard and cold. Two adults are needed to rnea- such as glottic closure during forced expiration and airwy occlu- sure an infant, who should be placed supine onto the stadiome sion prrrcedures. ter, One adult positions the haws head so that it is touching the To avoid confusion and aid comparisons, R is important that top of the stadiometer. in the midline (as indicated by the central Myposition is recorded at the time of measurement. Ahhough black line on most stadiometers), while at the same time ensur- historically most measurements in infants have been undertaken ing that the baby's trunk is lying flat and not rotated on the bed. wjth the infant in the supine or lateral position, there is an increas- When this has been achieved, the ather adult gently depresses ing tendency to measure intubated neonates in the pmne posi- the infant's knees until the legs are fully extended. The adjusta- tion. Better oxygenation has been found in neonates recovering ble footplate on the stadiometer should be moved up smoothly from respiralory distress syndrome when in the prone position until it rests against the soles of the infanfs feet, the feet being (22,23).However, there are no normative PFT data for prone in- in the midline (as indicated by the central black line). When this fants. has been achieved, the lever is tumedto fix the hotplate and the length read off the counter. This measurement sharld hrepeated at least twice, until two recordings within 05 cm of each other are dined. The infanfs length is reported to one decimal place. The Most term or preterm neonates can be stdiduring natuml sleep fmtplate should always be moved gently to avoid damage to the without sedation. Beyond 1 rno of age, houlfwer, it bmesin- counter. The calibration of the stadiometer shoutd be checked at creasingly difficuk la dc so. Sleep deprivation, even if brief, sig- least weekly, using a purpsernade steel rod of known length. nifiwntly disrupts sleep patterns and increases cenlral and crb- At themetime, the minimum counter readiy should Ise checked structive apneic episodes (24), and is not recommended. against that specified on each stadiwneter. The use and type of sedation wiIl depend on the age and con- As cbhing varies seasonaify and geographi~ily,all weigh& difion of the infant, the reason for the test, and the type of test should be reported as naked weight (8). being performed. The safety of sedative agents has practical and ethical implicatfons, in that these drugs are mrnmonly used for FEEDING diagnostic lung function assessments and for esmblishing refer- ence values in normal irrfane. Currently, the most commonly used Tests tend to be more successful if the infant is M, clean, and sedative agents for PFT are chloral derivatives. Some centets are dry. Providing the infant is Wing enterally, masl workers feel using rnidazolarn.
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