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Table-S1. Kyoto Encyclopedia of and (KEGG) pathways and (GO) biological processes for the list of cognin interacting identified in cytoplasmic and P2 mitochondrial-plasma membrane fractions of chick forebrain

Protein name NCBI accession Gene name KEGG GO (level 4) regulation of actin filament-based process, regulation of complex assembly, regulation of cellular component size, cellular component disassembly, regulation of anatomical structure size, negative regulation of cellular component organization, regulation of cellular component Spectrin alpha chain, biogenesis, actin cytoskeleton NP_001036003.1 SPTAN1 Apoptosis non-erythrocytic 1 organization, supramolecular fiber organization, protein-containing complex subunit organization, regulation of cellular component organization, cellular component assembly, organization, negative regulation of cellular process, negative regulation of biological process, regulation of cellular process Spectrin beta chain, NP_001186354.1 SPTBN1 brain 1 Clathrin heavy chain NP_001073586.1 CLTC Lysosome, Endocytosis 1 potassium ion transmembrane transport, Na/K ATPase alpha3 1704129B ATP1A3 cellular chemical homeostasis, subunit homeostatic process, transport potassium ion transmembrane transport, regulation of neurotransmitter levels, Na/K ATPase alpha2 muscle system process, regulation of 1704129A ATP1A2 subunit system process, cellular chemical homeostasis, homeostatic process, regulation of multicellular organismal 2

process, transport dynamin-1 isoform XP_004945888.1 DNM1 Endocytosis X11 Vesicle-fusing NP_001019627.1 NSF ATPase endoplasmic reticulum unfolded protein response, negative regulation of response to endoplasmic reticulum stress, 'de novo' protein folding, protein refolding, chaperone-mediated protein folding, response to topologically incorrect protein, response to heat, response to temperature stimulus, regulation of binding, regulation of cellular response to stress, response to nitrogen compound, negative regulation of molecular function, negative regulation of , negative regulation of communication, negative regulation of 78 kDa - signaling, regulation of response to Protein export, Protein processing in regulated protein – Q90593.1 HSPA5 stress, negative regulation of response to endoplasmic reticulum GRP78 stimulus, organic substance catabolic process, cellular catabolic process, cellular response to stress, response to organic substance, cellular response to chemical stimulus, regulation of signal transduction, regulation of cell communication, regulation of signaling, regulation of response to stimulus, negative regulation of cellular process, negative regulation of biological process, signal transduction, protein metabolic process, organonitrogen compound metabolic process, cellular metabolic process, macromolecule metabolic process, 3

regulation of cellular process 'de novo' protein folding, protein refolding, chaperone-mediated protein folding, response to topologically incorrect protein, response to heat, microtubule-based movement, response to temperature stimulus, autophagy, cellular component disassembly, embryonic morphogenesis, embryo development, intracellular transport, cellular macromolecule localization, establishment of protein localization, establishment of localization in cell, Spliceosome, Protein processing in organic substance catabolic process, heat shock cognate 70 CAA06233.1 HSPA8 endoplasmic reticulum, Endocytosis, cellular catabolic process, cellular MAPK signaling pathway response to stress, protein localization, protein-containing complex subunit organization, response to organic substance, cellular response to chemical stimulus, anatomical structure morphogenesis, animal organ development, transport, system development, protein metabolic process, multicellular development, organonitrogen compound metabolic process, cellular nitrogen compound metabolic process, macromolecule metabolic process response to cold, 'de novo' protein folding, protein refolding, chaperone- mediated protein folding, response to Spliceosome, Protein processing in 70 kDa heat shock topologically incorrect protein, response AAA48825.1 HSPA2 endoplasmic reticulum, Endocytosis, protein to heat, response to temperature stimulus, MAPK signaling pathway response to nitrogen compound, response to , response to hormone, response to oxygen-containing compound, cellular 4

response to stress, response to organic substance, cellular response to chemical stimulus, transport vesicle docking involved in exocytosis, organelle localization by membrane Syntaxin-binding tethering, exocytosis, organelle NP_001292577.1 STXBP1 protein 1 localization, establishment of protein localization, protein localization, transport cell communication by chemical coupling, positive regulation of receptor localization to synapse, cell communication by electrical coupling, receptor localization to synapse, maintenance of protein location in cell, regulation of synaptic plasticity, dendritic spine development, postsynapse organization, maintenance of protein location, localization within membrane, regulation of synapse structure or activity, maintenance of location in cell, dendrite development, regulation of Drebrin 1610233A DBN1 trans-synaptic signaling, maintenance of location, synapse organization, positive regulation of development, synaptic signaling, regulation of cellular localization, actin cytoskeleton organization, supramolecular fiber organization, regulation of anatomical structure morphogenesis, positive regulation of cell differentiation, positive regulation of cellular component organization, cellular macromolecule localization, positive regulation of developmental process, cell projection organization, cell-cell 5

signaling, cellular component morphogenesis, positive regulation of multicellular organismal process, regulation of cell differentiation, regulation of multicellular organismal development, regulation of localization, protein localization, regulation of cellular component organization, regulation of developmental process, cell development, regulation of multicellular organismal process, regulation of cell communication, regulation of signaling, anatomical structure morphogenesis, organelle organization, cell differentiation, system development, positive regulation of cellular process, positive regulation of biological process, multicellular organism development, regulation of cellular process - NP_989826.1 CRMP1 related protein 1 developmental growth involved in morphogenesis, developmental , regulation of developmental growth, regulation of cellular component size, neuron projection guidance, regulation of cell growth, regulation of anatomical structure size, chemotaxis, Dihydropyrimidinase- Q90635.1 DPYSL2 taxis, regulation of growth, head related protein 2 development, regulation of anatomical structure morphogenesis, cell projection organization, cellular component morphogenesis, regulation of cell differentiation, regulation of multicellular organismal development, regulation of cellular component organization, 6

regulation of developmental process, cell development, regulation of multicellular organismal process, anatomical structure morphogenesis, animal organ development, organelle organization, cell differentiation, system development, multicellular organism development, regulation of cellular process C kinase substrate - AAA48946.1 MARCKS MARCKS ATP synthase subunit Oxidative phosphorylation, Metabolic NP_989617.1 ATP5A1Z alpha, mitochondrial pathways generation of precursor and energy, angiogenesis, blood vessel development, nucleobase-containing metabolic process, tube morphogenesis, drug metabolic process, tube development, organophosphate metabolic process, carbohydrate derivative metabolic process, intracellular transport, anatomical structure formation involved in morphogenesis, establishment of ATP synthase subunit Oxidative phosphorylation, Metabolic localization in cell, anatomical structure Q5ZLC5.1 ATP5F1B beta, mitochondrial pathways morphogenesis, phosphorus metabolic process, transport, system development, multicellular organism development, nucleobase-containing compound metabolic process, heterocycle metabolic process, cellular aromatic compound metabolic process, cellular biosynthetic process, organic substance biosynthetic process, organic cyclic compound metabolic process, organonitrogen compound metabolic process, cellular nitrogen compound metabolic process 7

ErbB signaling pathway, GnRH signaling pathway, Melanogenesis, Calcium/calmodulin- Oocyte meiosis, Adrenergic signaling in dependent kinase II AAC98390.1 CAMK2A cardiomyocytes, Necroptosis, Wnt alpha protein signaling pathway, Calcium signaling pathway Chain K, Remodeling Of Actin Filaments Not 3J0S_K By Adf Cofilin available Protein Heterogeneous nuclear NP_001012610.1 HNRNPH3 ribonucleoprotein H3 regulation of killing of cells of other organism, positive regulation of killing of cells of other organism, killing of cells in other organism involved in symbiotic interaction, positive regulation of cell killing, regulation of cell killing, interaction with symbiont, interaction with host, response to fungus, antimicrobial humoral response, positive regulation of multi-organism process, glyceraldehyde-3- Glycolysis / Gluconeogenesis, modification of morphology or phosphate P00356.3 GAPDH of amino acids, Carbon physiology of other organism, cytokine dehydrogenase , Metabolic pathways secretion, regulation of symbiosis, encompassing mutualism through parasitism, humoral immune response, symbiont process, positive regulation of protein transport, positive regulation of establishment of protein localization, regulation of protein stability, regulation of multi-organism process, neuron death, monosaccharide metabolic process, positive regulation of cytokine production, positive regulation of 8

secretion, positive regulation of secretion by cell, positive regulation of cell death, protein secretion, generation of precursor metabolites and energy, innate immune response, membrane organization, regulation of cytokine production, regulation of secretion by cell, microtubule cytoskeleton organization, carbohydrate metabolic process, defense response to other organism, positive regulation of transport, cofactor metabolic process, regulation of protein localization, nucleobase-containing small molecule metabolic process, response to external biotic stimulus, negative regulation of molecular function, small molecule biosynthetic process, drug metabolic process, negative regulation of cell death, organic acid metabolic process, organophosphate metabolic process, defense response, carbohydrate derivative metabolic process, regulation of transport, regulation of cell death, establishment of protein localization, positive regulation of multicellular organismal process, programmed cell death, organic substance catabolic process, negative regulation of biosynthetic process, cellular catabolic process, regulation of localization, regulation of catalytic activity, protein localization, negative regulation of nitrogen compound metabolic process, negative regulation of cellular metabolic process, response to organic substance, negative regulation of macromolecule 9

metabolic process, regulation of multicellular organismal process, cellular response to chemical stimulus, negative regulation of metabolic process, phosphorus metabolic process, transport, organelle organization, negative regulation of cellular process, regulation of biosynthetic process, negative regulation of biological process, positive regulation of cellular process, positive regulation of biological process, protein metabolic process, regulation of nitrogen compound metabolic process, regulation of primary metabolic process, regulation of macromolecule metabolic process, regulation of cellular metabolic process, nucleobase-containing compound metabolic process, regulation of metabolic process, heterocycle metabolic process, cellular aromatic compound metabolic process, cellular biosynthetic process, organic substance biosynthetic process, organic cyclic compound metabolic process, organonitrogen compound metabolic process, cellular nitrogen compound metabolic process, cellular macromolecule metabolic process, macromolecule metabolic process, regulation of cellular process