Customized Book List Life Science

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Springer Customized Book List Life Science

FRANKFURT BOOKFAIR 2007 springer.com/booksellers Life Science 1

M.M. Abdelhaleem, University of Toronto, ON, Canada (Ed.) Transactions on Computational Single Molecules and Systems Biology VIII Nanotechnology Helicases

Helicases are enzymes that utilize the energy derived The LNCS journal Transactions on Computation- This book focuses on recent advances in the rapid- from NTP hydrolysis to unwind double standed nual Systems Biology is devoted to inter- and multi- ly evolving field of single molecule research. These cleic acids. Significant progress has been achieved in disciplinary research in the fields of computer sci- advances are of importance for the investigation our understanding of the structure and molecular ence and life sciences and supports a paradigmat- of biopolymers and cellular biochemical reactions, mechanisms of helicases. The reader will find proto- ic shift in the techniques from computer and infor- and are essential to the development of quantita- cols utilized by leading experts in the field that span mation science to cope with the new challenges aris- tive biology. Written by leading experts in the field, different species and cover various biological pro- ing from the systems oriented point of view of bio- the articles cover a broad range of topics, including: cesses in which helicases are involved. This volume logical phenomena. The six papers selected quantum photonics of organic dyes and inorgan- will be useful to students and researchers interested for this special issue are:Bio-inspired Network-Cen- ic nanoparticles their use in detecting properties of in this rapidly expanding filed. tric Operation and Control for Sensor/Actuator single molecules the monitoring of single molecule Networks;A Computationally Fast and Parametric (enzymatic) reactions single protein (un)folding in Fields of interest Model to Estimate Protein-Ligand Docking Time nanometer-sized confined volumes the dynamics of Cell Biology; Molecular Medicine for Stochastic Event Based Simulation;Equation- molecular interactions in biological cells The book Based Congestion Control in the Internet Bio- is written for advanced students and scientists who Target groups logic Environment;Computational Thinking in wish to survey the concepts, techniques and results Molecular and cellular biologists, students and re- Biology;End-to-End Information Management for of single molecule research and assess them for their searchers Systems Biology;and a corrected version of: On Dif- own scientific activities. ferentiation and Homeostatic Behaviours of Boolean Type of publication Dynamical Systems Features Contributed volume - Comprehensive overview on the fast developing Fields of interest field of single molecule detection- -Written by ex- Due September 2009 Computation by Abstract Devices; Bioinformatics; perts in the field Mathematical Logic and Formal Languages; Algo- rithm Analysis and Problem Complexity Contents 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary 1. Nanophotonics and Single Molecules.- 2. Single entry 2259) Hardcover Target groups Biomolecules at Cryogenic Temperatures: From 76,65 € Researchers and professionals Structure to Dynamics.- 3. Quantum Optics: Col- ISBN 978-1-60327-354-1 loidal Fluorescent Semiconductor Nanocrystals Type of publication (Quantum Dots) in Single-Molecule Detection and Collected works Imaging.- 4. Scanning Fluorescence Correlation Spectroscopy.- 5. Single Molecule Imaging of Cellu- Due November 2007 lar Signaling.- 6. Signaling and Mobility of Single Re- ceptor Proteins.- 7. Single Enzyme Kinetics. A Study of the Yeast Enzyme Candida Antarctica.- 8. Protein 2007. VII, 103 p. (Lecture Notes in Computer Science, Vol. 4780) Softcover Folding and Dynamics from Optical Single Molecule Spectroscopy.- 9. Single Molecules and Nanoscale [..] 49,00 € ISBN 978-3-540-76638-4 Fields of interest Biophysics; Nanotechnology; Biochemistry, general; Physical Chemistry

Target groups libraries, institutes, scientists, advanced students

Type of publication Contributed volume

Due November 2007

2008. Approx. 340 p. 96 illus. 25 in color. (Springer Series in Bio- physics, Vol. 12) Hardcover

159,95 € ISBN 978-3-540-73923-4 2 Life Science springer.com/booksellers

C. Abdelly, INRST, Hammam-Lif, Tunisia; M. Öztürk, Ege Universi- J. Adams, Rutgers University, New Jersey, USA A.I. Agoulnik, Baylor College of Medicine, Houston, TX, USA (Ed.) ty, Izmir, Turkey; M. Ashraf, University of Agriculture, Faisalabad, Pakistan; C. Grignon, Université de Montpellier, France (Eds.) Patterns in the Diversity of Life Relaxin and Related Peptides Biosaline Agriculture and High Salinity Tolerance This is a readable, informative and up-to-date ac- Relaxin and Related Peptides discusses the estab- count of the patterns and controls on biodiversity. lished paradigms, the contradictions, and the most The author describes major trends in species rich- recent findings and future directions in the field of A major threat to agricultural productivity world- ness, along with uncertainties in current knowl- relaxin research. The array of diverse topics are high- wide is undoubtedly due to environments with edge. The various possible explanations for past and lighted, ranging from evolution of relaxin family stressful factors including drought, salinity, water- present species patterns are discussed and explained peptides and receptors to their cell signaling, from logging, extreme temperatures, non-optimal levels in an even-handed and accessible way. The implica- the role of relaxin in reproduction to the newly dis- of mineral nutrients etc. Based on contributions pre- tions of global climate change and habitat loss are covered functions in cancer progression and in the sented at the International Conference on Biosaline considered, along with current strategies for preserv- nervous system. The four major ongoing areas of re- Agriculture and High Salinity Tolerance in Novem- ing what we have. This book examines the state of search described in this book will likely attract inves- ber 2006 in Gammarth, Tunisia, this book reviews current understanding of species richness patterns tigators for years to come, since many basic scien- the current state of knowledge in biosaline agricul- and their explanations. As well as the present day tific questions remain unanswered at this time. The ture and high salinity tolerance in plants. It main- world, it deals with diversification and extinction, in availability of structural databases, new experimental ly focuses on the biotic approach to economically the conservation of species richness, and the difficul- techniques, and high quality hormone preparations, utilize the stress-prone areas by growing resistant ties of assessing how many species remain to be dis- antibodies and other reagents enable rigorous inves- plants. This volume comprises three sections: molec- covered. The scientifically compelling subject of veg- tigation. Relaxin and Related Peptides offers a fresh ular biology, physiology and biochemistry, and ecol- etation-climate interaction is considered in depth. perspective along with different points of view, opin- ogy. Thus, a systematic approach has been adopted Written in an accessible style, the author offers an ions and disagreements. to uncover plant responses to various ecological fac- up-to-date, rigorous and yet eminently comprehensi- tors at physiological and molecular levels. It is of in- ble overview of the ecology and [..] Features terest to students, researchers and professionals in Is intended to show the established paradigms and plant physiology, molecular biology, biotechnology, Features the contradictions, the most recent findings and the agriculture, soil science, and environmental biology. A highly readable, accessible yet rigorous and up- future directions in the field of relaxin research to-date account of th important ecological questions Features surrounding biological diversity. Contents Supported by UNESCO Doha, Qatar International The Evolution of the Relaxin Peptide Family and authorship Complements the volume M. Öztürk/ Contents their Receptors.- Relaxin, The Relaxin-Like Factor Y. Waisel/M. Ajmal Khan/G. Görk, Biosaline Agri- Preface: Why the book was written, aims of the book, and their Receptors.- Diverse Signalling Mechanisms culture and Salinity Tolerance in Plants. 2006, acknowledgements; 1. Latitudinal gradients; -2. The used by Relaxin in Natural Cells and Tissues: The Birkhäuser Publishing depth of time;-3. Hotspots in species richness;- 4. Evolution of a “Neohormone”.- Relaxin Physiolo- Local scale patterns in species richness;- 5. gy in the Female Reproductive Tract during Preg- Fields of interest Knowing what is out there;- 6: Humans and extinc- nancy.- Relaxin and Related Peptides in Male Repro- Agriculture; Plant Ecology; Plant Physiology; Envi- tions in history and prehistory;-7. Present threats – duction.- The Vascular Actions of Relaxin.- The Ef- ronmental Biotechnology; Ecosystems habitat change and global change;- 8. Conserving fects of Relaxin on Extracellular Matrix Remodeling what we have. in Health and Fibrotic Disease.- Relaxin-Like Lig- Target groups and-Receptor Systems are Autocrine/Paracrine Ef- Scientific libraries; researchers; agricultural and envi- Fields of interest fectors in Tumor Cells and Modulate Cancer [..] ronmental orientated institutions Biodiversity; Ecology; Environment, general; Ecosys- tems; Nature Conservation Fields of interest Type of publication Endocrinology; Cell Biology; Cancer Research Proceedings Type of publication Monograph Target groups Due January 2008 Endocrinologists, reproductive biologists, molecu- Due January 2008 lar/cell biologists, and cancer biologists 2008. Approx. 300 p. Hardcover Type of publication Jointly published with Praxis Publishing, UK Contributed volume 119,00 € ISBN 978-3-7643-8553-8 2008. Approx. 320 p. (Environmental Sciences) Hardcover Due November 2007

99,95 € ISBN 978-3-540-74277-7 2008. Approx. 170 p. (Advances in Experimental Medicine and Biology, Vol. 612) Hardcover

114,95 € ISBN 978-0-387-74670-8 springer.com/booksellers Life Science 3

J.M. Aguilera, Universidad Católica de Chile, Santiago, Chile; P.J. M. Alexander, Conservation Management System Consortium, J.F. Allen, University of London, UK; B. Osmond, Durham, USA; Lillford, University of York, Heslington, UK (Eds.) UK J.H. Golbeck, Penn State University, USA; E. Gantt, University of Maryland, USA (Eds.) Food Materials Science Management Planning for Nature Conservation Proceedings Photosynthesis Principles and Practice Research 2007 A Theoretical Basis & Practical Guide 14th International Congress on Photosynthesis Research 2007 Food Materials Science provides the science behind held in Glasgow, United Kingdom, 22-27 July 2007 structuring processes for foods and applications in Mike Alexander’s Management Planning for Nature food product design. The first in its field, the book is Conservation brings a new dimension to the modern an invaluable reference. The creation of added value literature on conservation management. Combin- from raw food materials is a legitimate aspiration of Fields of interest ing key theories with real practice it fills a critical gap the modern food industry. Adding value to foods re- Plant Sciences; Biochemistry, general; Developmen- which has often hindered in-depth understanding quires knowledge of what the consumer wants and tal Biology of the planning process. The book provides histori- creating products that satisfy the demand. Quality, cal and rational background which helps to explain convenience and safety are the major drivers of the Type of publication what makes a really effective management plan, and modern food industry. Food manufacture is about Proceedings it presents a detailed practical guide to developing producing billions of units of standardized products such a plan. It concludes with a series of case stud- which must be cheap, nutritious, safe and appealing ies which clearly illustrate the underlying principles Due February 2008 to the consumer’s taste. Food products are complex drawn out in the text, while highlighting the different multicomponent and structured edible materials that approaches demanded by very different sites. Draw- 2008. Approx. 1800 p. Hardcover nevertheless must comply with the laws of physics ing on the expertise of leaders in both conservation and fundamentals of engineering sciences. In the research and wildlife management, and with a com- 600,00 € last 20 years the design of food products with specif- bined experience from around the world, this book is ISBN 978-1-4020-6707-5 ic functionalities has advanced significantly by the essential reading for professional conservation man- application of scientific knowledge from disciplines agers and any student studying management plan- such as polymer physics, [..] ning for conservation within a range of degree and Features postgraduate courses. The book will be [..] Great as a text in a course in food materials science at Features the senior or graduate level or as a supplemental text The only planning guide which meets the require- in an advanced food technology course Will serve as ments of Natura 2000 sites Introduces the concept a reference book for professionals in the food indus- of adaptable management – a proven practical ap- try proach to flexible management planning Entirely Contents consistent with the RAMSAR planning guidelines Fundamentals: Why Food Materials Science?- The Equally suitable for students and practitioners Composite Structure of Biological Tissue used for Contents Food.- Food Polymers.- The Crystalline State.- The Foreword.- Acknowledgements.- Introduction.- 1. Glassy State.- Rubber elasticity and Wheat Gluten Why Plan?.- 2. Structure, Preparation and Proteins.- State Diagrams of Food Materials.- Nan- Precautionary Principle.- 3. Language and Audi- otechnology in Food Materials Research.- Assembly ence.- 4. Local Communities and Stakeholders.- 5. of Structures in Foods.- Solid Food Foams.- Prob- Survey, Surveillance, Monitoring and Record- ing Food Structures.- Structuring Operations: Struc- ing.- 6. Adaptable Management, Review and Audit.- ture-property relationships in foods.- Structuring 7. Ethics and Conservation Management or Why Water by Gelation.- Bubble Containing Foods.- Conserve Wildlife?.- 8. What Do We Value?.- 9. Ap- Emulsions: Principles and Preparation.- Processing proaches to Conservation Management.- 10. Legisla- of Food Powders.-Fat Crystal Networks.- [..] tion and Policy.- 11. Description .- 12. Features and Fields of interest Evaluation.- 13. Factors.- 14. Objectives for Biologi- Food Science; Chemistry/Food Science, general; cal Features.- 15. Rationale for Biological and Other Physical Chemistry [..]

Target groups Fields of interest Food materials science courses or at the senior or Environmental Management; Nature Conservation; graduate level, professionals in the food industry Applied Ecology

Type of publication Target groups Contributed volume Post graduate students in countryside management courses, students at any level on conservation science or conservation management courses, professional Due December 2007 conservation and countryside managers

2008. Approx. 696 p. (Food Engineering Series) Hardcover Type of publication Graduate/advanced undergraduate textbook 114,95 € ISBN 978-0-387-71946-7 Due October 2007

2008. Approx. XX, 414 p. Softcover

59,95 € ISBN 978-1-4020-6580-4 4 Life Science springer.com/booksellers

B.J. Alloway, University of Reading, UK (Ed.) L. Almasy, Southwest Foundation for Biomedical Research, San D.M. Alongi, Australian Institute of Marine Science, Townsville, Antonio, TX (Ed.) Australia Micronutrient Deficiencies in Global Crop Production Statistical Genetics The Dynamics of Tropical Mangrove Forests

A deficiency of one or more of the eight plant mi- Fields of interest cronutrients (boron, chlorine, copper, iron, man- Genetics and Population Dynamics Tropical mangrove forests are disappearing at an ganese, molybdenum, nickel and zinc) will adversely alarming rate, despite their importance in sustain- affect both the yield and quality of crops. Micronu- Type of publication ing livelihoods for many people living along some trient deficiencies in crops occur in many parts of Contributed volume of the world’s most populous coastlines. Mangrove the world, at various scales (from one to millions of forests occupy a crucial place between land and sea, being a valuable ecological and economic resource. hectares), but differences in soil conditions, climate, Due October 2009 crop genotypes and management, result in marked These ecosystems are nursery grounds and breed- variations in their occurrence. The causes, effects ing sites for organisms and a source of wood, tradi- and alleviation of micronutrient deficiencies in crops 2008. (Methods in Molecular Biology, Preliminary entry 2145) tional foods and medicines. They are accumulation in: Australia, India, China, Turkey, the Near East, Hardcover sites for sediment, contaminants, carbon and nutrients, offering protection against coastal erosion. Africa, Europe, South America and the United States 74,95 € An overview is presented of mangrove forest ecosys- of America, are covered, and these are representa- ISBN 978-1-58829-728-0 tive of most of the different conditions under which tems; how they live and grow at the edge of tropical crops are grown anywhere in the world.Links be- seas and play a critical role along most of the tween low contents of iodine, iron and zinc (human world’s tropical coasts, including their future in a micronutrients) in staple grains and the incidence of world of climate change. Such an approach is human health problems are discussed, together with necessary in order to further understand the role of the ways in which the micronutrient content of food these dynamic forests in ecosystem function, and as a crops can be increased and their [..] first step towards developing adequate strategies for their conservation and sustainable use and [..] Features Provides an up to date account of the incidence of Features micronutrient deficiencies in countries, regions and Comprehensive analysis of the functional role of continents representative of most of the different mangrove forests and their ecosystems Global syn- conditions under which crops are grown anywhere thesis of how mangrove forests are important func- in the world Deals with the physiological functions tionally in terms of the tropical carbon cycle A mul- of boron, chlorine, copper, iron, manganese, molyb- ti-disciplinary approach to better understand tropi- denum and zinc in higher plants and the effects that cal mangrove forests, especially what they do rather deficiencies have on these functions The links be- than what they are tween [..] Fields of interest Contents Ecology; Ecosystems; Marine Ecology; Forestry Preface; Table of Contents; List of Contributors; List of Figures; List of Tables; List of AbbreviationsChap- Target groups ter 1. Micronutrients and Crop Production: An In- Researchers, students, forest managers, coastal troduction, Brian J. AllowayChapter 2. Micronutri- ecosystem managers. ent Deficiencies in Crops and Their Global Signif- Type of publication icance, Robin D. GrahamChapter 3.Micronutrient Monograph Deficiencies in Australian Field Crops, Robert E. Holloway, Robin D. Graham and Samuel P. Stacey- Chapter 4. Micronutrient Deficiencies in Crops and Due November 2008 Soils in India, Maha V. SinghChapter 5. Micronutri- ent Deficiencies in Crop Production in China, Chun- 2008. Approx. 320 p. Hardcover quin Zou, Xiaopeng Gao, Rongli Shi, Xiaoyun [..] 125,00 € Fields of interest ISBN 978-1-4020-4270-6 Agriculture; Plant Sciences; Plant Physiology; Soil Science & Conservation

Target groups Research soil scientists, plant nutritionists, agronomists, agricultural extension workers, agricultural consultants and advisors, fertiliser company sales representatives and staff in government and international agencies

Type of publication Contributed volume

Due January 2008

2008. Approx. 300 p. Hardcover

100,00 € ISBN 978-1-4020-6859-1 springer.com/booksellers Life Science 5

C. Alonso, INIA, Madrid, Spain (Ed.) C.D. Amsler, University of Alabama at Birmingham, AL, USA (Ed.) D.R. Anderson, Colorado State University, Fort Collins, CO, USA

Viruses and Apoptosis Algal Chemical Ecology Model Based Inference in the Life Sciences

A Primer on Evidence The interactions between viruses and the cells they This is the first ever book devoted entirely to the infect include the virus control of cellular functions chemical ecology of algae. Algae from both marine to their advantage. The cell counteracts with a de- and freshwater habitats are covered, as are macroal- fensive immune system and stress responses. Both gae (seaweeds) and microalgae (including phyto- The abstract concept of “information” can be quan- sides of this struggle include modifications in the cell plankton). While its main emphasis is on the eco- tified and this has led to many important advances death program that will be crucial for the infection logical rather than chemical aspects of the field, the in the analysis of data in the empirical sciences. This outcome. In this book, molecular pathways regulat- book also includes a unique introductory chapter in- text focuses on a science philosophy based on “mul- ed by viral genes and their role in the pathogenesis tended as a primer on algal natural products chem- tiple working hypotheses” and statistical models of infection are analysed in different viral models. It istry for ecologists. It elucidates the roles of chemi- to represent them. The fundamental science ques- also includes a didactic update of known signaling cal defenses in various regions and habitats, of DM- tion relates to the empirical evidence for hypothe- pathways in apoptosis and their role in normal and SP, oxidative burst responses, and herbivore offense. ses in this set—a formal strength of evidence. Kull- infected cells. Special emphasis was given to molec- Topics such as algal sensory chemical ecology and back-Leibler information is the information lost ular pathways underlying viral transformation and defenses against ultraviolet radiation are also treat- when a model is used to approximate full reality. Hi- oncogenesis and to the perspectives in cancer gene ed, and an introduction to the chemical ecology of rotugu Akaike found a link between K-L informa- therapy. Particular cell types in apoptosis such as phytoplankton is provided. Focusing on recent ad- tion (a cornerstone of information theory) and the neuronal cells and lymphoid cell death are also em- vances and also on topics particularly useful for un- maximized log-likelihood (a cornerstone of mathe- phasized. This book is designed to give an in-depth dergraduate and graduate level courses, Algal Chem- matical statistics). This combination has become the update of viral gene interaction with regulation path- ical Ecology is designed for research biologists work- basis for a new paradigm in model based inference. ways in apoptosis for scientists and researchers in the ing in the field as well as marine ecologists and algal The text advocates formal inference from all the hy- fields of molecular [..] biologists seeking an introductory guide. potheses/models in the a priori set—multimodel inference. This compelling approach allows a simple Features Features ranking of the science hypothesis and their models. Latest book to describe molecular pathways con- The first ever book focusing on algal chemical ecolo- Simple methods are introduced for computing the trolled by viral genes and the new perspectives this gy An invaluable source of information both for re- likelihood [..] knowledge opens for gene and cancer therapy search biologists working in the field and for marine ecologists and algal biologists seeking an introducto- Features Contents ry guide Very broad applicability, very science-based, and Cell Death Suppressors Encoded by Cy- practical Very powerful – the concept of formal tomegalovirus.- Apoptosis Regulator Genes Encoded Contents “strength of evidence” Simple to use and understand by Poxvirus.- T Cell Mediated Control of Poxvirus The chemistry of algal secondary metabolism.- An emphasis on science philosophy, not just “data Infection in Mice.- Switching on and off the Cell Macroalgal chemical defenses and their roles in analysis” Death Cascade: African Swine Fever Virus Apop- structuring tropical marine communities.- Macroal- tosis Regulation.- Sindbis Virus Induces Neuronal gal chemical defenses and their roles in structur- Contents Cell Death and Lethal Encephalitis.- Apoptosis Path- ing temperate marine communities.- Macroalgal Introduction--science hypotheses and science phi- ways Triggered by HIV and Consequences on T Cell chemical defenses in polar marine communities.- losophy.- Data and models.- Information theory and Homeostasis and HIV-Specific Immunity.- HIV Macroalgal and cyanobacterial chemical defenses in entropy.- Quantifying the evidence about science hy- and Apoptosis: A Complex Interaction Between Cell freshwater communities.- New perspectives for ad- potheses.- Multimodel inference.- Advanced topics.- Death and Virus Survival.- Poliovirus and Apopto- dressing patterns of secondary metabolites in marine Summary. sis.- Flaviviruses and Apoptosis Regulation.- Manip- macroalgae.- Macroalgal models in testing and ex- ulatin of Apoptosis [..] tending defense theories.- Ecological and physiologi- Fields of interest cal roles of dimethylsulfoniopropionate (DMSP) and Statistics for Life Sciences, Medicine, Health Sci- Fields of interest DMSP [..] ences; Environmental Computing/Environmental Cell Biology; Cancer Research; Biochemistry, general Modelling; Ecology; Evolutionary Biology; Epidemi- Fields of interest ology; Methodology of the Social Sciences Target groups Marine Ecology; Molecular Ecology; Limnology; Mi- Scientists, graduates, lecturers, advanced students crobial Ecology; Plant Ecology Target groups Grad students, scientists Type of publication Target groups Monograph Researchers, lecturers, and advanced students Type of publication Graduate/advanced undergraduate textbook Due October 2007 Type of publication Contributed volume Due December 2007 2008. XVI, 342 p. 26 illus. (Progress in Molecular and Subcellular Biology, Vol. 36) Softcover Due October 2007 2008. Approx. 190 p. Softcover

59,95 € 2008. XVIII, 313 p. 26 illus. Hardcover 30,80 € ISBN 978-3-540-74263-0 ISBN 978-0-387-74073-7 149,95 € ISBN 978-3-540-74180-0 6 Life Science springer.com/booksellers

L. Andrews, University of Alabama at Birmingham, AL, USA; T.O. M.D. Annable, University of Florida, Gainesville, FL, USA.; M. Tollefsbol, University of Alabama at Birmingham, Birmingham, Teodorescu, National Research and Design Institute for Industrial 2008. Approx. 285 p. (NATO Science for Peace and Security Series AL, USA (Eds.) Ecology - ECOIND, Bucharest, Romania; P. Hlavinek, Brno Univer- C: Environmental Security) Hardcover sity of Technology, Brno, Czech Republic; L. Diels, VITO NV, Mol, Belgium (Eds.) 139,95 € Telomerase Inhibition ISBN 978-1-4020-6873-7 Strategies and Protocols Methods and Techniques for Cleaning-up Contaminated Sites

This volume presents a compendium of the most recent and advanced methods applied to the rapidly Soil and groundwater pollution caused by contam- expanding field of telomerase inhibition. The tech- inants including petroleum hydrocarbons, repre- niques described provide the researcher with a di- sent a serious threat to the environment in NATO verse and comprehensive set of tools for the study of and NATO Partner countries. Solutions are needed telomerase inhibition. that represent practical alternatives to costly remedi- Features al strategies yet still yield benefits to site managers. A compendium of the most recent and advanced This publication comprises the presentations made methods applied to the rapidly expanding field of at the NATO Advanced Research Workshop held in telomerase inhibition Provides the researcher with a Sinaia, Romania 9 – 11 October, 2006. The contribu- diverse and comprehensive set of tools tions represent a wide range of issues and challenges related to contaminated site management from low Contents cost solutions to petroleum contaminated sites to ad- Methods of Telomerase Inhibition.- Telomerase In- vances in biological treatment methods. This publi- hibition by Synthetic Nucleic Acids and Chemosen- cation is meant to foster links between groups facing sitization in Human Bladder Cancer Cell Lines.- challenges cleaning up contaminated sites through hTERT Knockdown in Human Embryonic Kidney presentations that explore the problems currently be- Cells Using Double-Stranded RNA.- RNA Interfer- ing addressed and solutions that are emerging in the ence Using a Plasmid Construct Expressing Short field. Hairpin RNA.- Retrovirus-mediated RNA Interfer- ence: Targeting hTERT Through Stable Expression Features of Short Hairpin RNA.- Telomerase Inhibition and THIS BOOK PRESENTS A UNIQUE CROSS-SEC- Telomere Targeting in Hematopoietic Cell Lines TION OF ISSUES AND CHALLENGES FACING with Small Non-Nucleosidic Synthetic Compounds NATO PARTNER COUNTRIES WITH SIGNIFI- (BIBR1532).- Uses of Telomerase Peptides in An- CANT LONG TERM ENVIRONMENTAL STEW- ti-tumor Immune Therapy.- [..] ARDSHIP MOVING FORWARD A WIDE RANGE OF INNOVATIVE APPROACHES TO MANAG- Fields of interest ING SITES ARE PRESENTED BY A GROUP OF Cell Biology; Cancer Research; Human Genetics; RESEARCHERS REPRESENTING A DIVERSE Biochemistry, general BACKGROUND OF EXPERIENCES. INSIGHTS PROVIDED IN THESE PAPERS MAY BE APPLI- Target groups CABLE TO SIMILAR SITE CHALLENGES FACES Biochemists, molecular biologists, cancer re- BY SITE MANAGERS [..] searchers, geneticists Contents Type of publication Remediation of Metal and Metalloid Contaminat- Contributed volume ed Groundwater.- Bioremediation In Situ of Pol- luted Soil in a Uranium Deposit.- Vital Soil Versus Due November 2007 Contaminants.-Chemical Oxidation for Clean Up of Contaminated Ground Water.- Detection and Measurement Techniques to Identify the Presence of 2007. Approx. 220 p. 31 illus. (Methods in Molecular Biology, Vol. NAPLs In the Field.- Immobilization of Heavy Met- 405) Hardcover als and Stable Organics from Aqueous Systems on 79,95 € Modified Activated Carbon.- Remediation of The ISBN 978-1-58829-683-2 former Military Airport: Triangle Zatec.-Aquifer Re- mediation and Chemical Recovery Following a Spill Due to an Earthquake in Turkey.- How to Remediate the Pollution [..]

Fields of interest Environmental Management; Hydrogeology; Envi- ronmental Computing/Environmental Modelling; Monitoring/Environmental Analysis/Environmental Ecotoxicology; Environmental Biotechnology

Target groups Scientists and engineers engaged in managing contaminated sites with significant challenges in terms of the extent and nature of the contamination present

Type of publication Proceedings

Due December 2007 springer.com/booksellers Life Science 7

M.D. Annable, University of Florida, Gainesville, Florida, U.S.A.; M. D. Anson, Women’s and Children’s Hospital, Australia (Ed.) Teodorescu, National Research and Design Institute for Industrial 2008. V, 280 p. (NATO Science for Peace and Security Series C: Ecology - ECOIND, Bucharest, Romania; P. Hlavinek, Brno Univer- Environmental Security) Softcover sity of Technology, Brno, Czech Republic; L. Diels, VITO NV, Mol, Reporter Genes: A Practical Guide Belgium (Eds.) 59,95 € ISBN 978-1-4020-6874-4

Methods and Techniques for Reporter genes have played, and continue to play, Cleaning-up Contaminated Sites a vital role in many areas of biological research by providing a ready means for qualitative and quantitative assessment of the activity of genes and location of gene products in different environments. This Soil and groundwater pollution caused by contam- book describes practical protocols for experimenta- inants including petroleum hydrocarbons, repre- tion with the most useful reporter genes for mam- sent a serious threat to the environment in NATO malian systems that are available and will concen- and NATO Partner countries. Solutions are needed trate on those marker genes that are currently most that represent practical alternatives to costly remedi- commonly used. al strategies yet still yield benefits to site managers. This publication comprises the presentations made Features at the NATO Advanced Research Workshop held in Provides practical guides for the use of the reporter Sinaia, Romania 9 – 11 October, 2006. The contribu- genes most commonly used in mammalian systems tions represent a wide range of issues and challenges including b-galactosidase, GFP and luciferase Easy related to contaminated site management from low to follow protocols for the use of reporter genes in cost solutions to petroleum contaminated sites to ad- various eukaryotic systems vances in biological treatment methods. This publication is meant to foster links between groups facing Contents challenges cleaning up contaminated sites through Methodologies for staining and visualisation of presentations that explore the problems currently be- galactosidase in embryos and tissues.- Immunohisto- ing addressed and solutions that are emerging in the chemical Detection of Beta-Galactosidase or Green field. Fluorescence Protein on Tissue Sections.- Detection of Reporter Gene Expression in Murine Airways.- Features Three dimensional analysis of molecular signals with THIS BOOK PRESENTS A UNIQUE CROSS-SEC- episcopic imaging techniques.- Fluorescent proteins TION OF ISSUES AND CHALLENGES FACING for cell biology.- Detection of GFP during nervous NATO PARTNER COUNTRIES WITH SIGNIFI- system development in Drosophila melanogaster.- CANT LONG TERM ENVIRONMENTAL STEW- Autofluorescent Proteins for Flow Cytometry.- Fluo- ARDSHIP MOVING FORWARD A WIDE RANGE rescent protein reporter systems for single cell mea- OF INNOVATIVE APPROACHES TO MANAG- surements.- Subcellular Imaging of [..] ING SITES ARE PRESENTED BY A GROUP OF RESEARCHERS REPRESENTING A DIVERSE Fields of interest BACKGROUND OF EXPERIENCES. INSIGHTS Animal Genetics and Genomics; Cell Biology PROVIDED IN THESE PAPERS MAY BE APPLI- CABLE TO SIMILAR SITE CHALLENGES FACES Target groups BY SITE MANAGERS [..] Geneticists, molecular engineers, molecular biologists Contents Remediation of Metal and Metalloid Contaminat- Type of publication ed Groundwater.- Bioremediation In Situ of Pol- Contributed volume luted Soil in a Uranium Deposit.- Vital Soil Versus Contaminants.-Chemical Oxidation for Clean Up Due October 2007 of Contaminated Ground Water.- Detection and Measurement Techniques to Identify the Presence of 2008. Approx. 175 p. 25 illus., 1 in color. (Methods in Molecular NAPLs In the Field.- Immobilization of Heavy Met- Biology, Vol. 411) Hardcover als and Stable Organics from Aqueous Systems on Modified Activated Carbon.- Remediation of The 79,95 € former Military Airport: Triangle Zatec.-Aquifer Re- ISBN 978-1-58829-739-6 mediation and Chemical Recovery Following a Spill Due to an Earthquake in Turkey.- How to Remediate the Pollution [..]

Target groups Scientists and engineers engaged in managing contaminated sites with significant challenges in terms of the extent and nature of the contamination present

Type of publication Proceedings

Due December 2007 8 Life Science springer.com/booksellers

T.M. Antalis, University of Maryland School of Medicine, Balti- D. Armstrong (Ed.) G.M. Artmann, Aachen University of Applied Sciences, Germany; more, MD, USA; Th. Bugge, National Institute of Dental and Cran- S. Chien, University of California, San Diego, CA, USA (Eds.) iofacial Research, Bethesda, MD, USA (Eds.) Advanced Protocols for Oxidative Stress Bioengineering in Cell and Tissue Proteases and Cancer Research

Contents Fields of interest This book reviews the latest technological develop- Microarrays for protease detection in tissues and Cell Biology ments of bioengineering approaches in cell and tis- cells.- Cell signaling in tumor cell invasion.- Activity sue research. It is meant to have life and spirit, and Type of publication based profiling for selective targeting of proteases.- to become a pioneer in technology and sciences, es- Contributed volume Atomic force microscopy (AFM) for imaging and pecially the life science. The chapters are written by quantification of local proteolytic activity.- Activi- excellent scientists on advanced, frontier technology ty-based probes for the proteomic profiling of met- Due September 2008 and address scientific questions that need consider- alloproteases.- Fluorescent detection of surface pro- able thinking in terms of engineering. The aims are to provide the readers, including students, faculty, teolysis.- Proteolytic Beacons.- Peptide libraries for 2008. (Methods in Molecular Biology, Preliminary entry 2235) Substrate Profiling.- Membrane protease proteomics: Hardcover and all scientists working in academia and industry, Isotope-coded affinity tag MS identification of pro- new information on bioengineering in cell and tissue tease substrates.- Protease cleavage sites using mix- 76,65 € research to enhance their understanding and innova- ture based oriented [..] ISBN 978-1-60327-218-6 tion.

Fields of interest Features Cell Biology Builds the Interface between Science and applications Reviews the state of the art in the strongly de- Type of publication veloping science Contributed volume Contents This book is composed of six sections covering a hi- Due September 2008 erarchy from genes to the universe. These sections are Genes, Genome and Information Network; Cell 2008. Approx. 300 p. (Methods in Molecular Biology, Preliminary and Tissue Imaging; Regenerative Medicine and Na- entry 2213) Hardcover noengineering; Mechanics of Soft Tissues, Fluids and Molecules; Bioengineering in Clinical Applications; 76,65 € Plant and Microbial Bioengineering. The chapters ISBN 978-1-60327-002-1 contain in particular: Genearrays and uHTS Assays.- Stem Cell Engineering.- Molecular and Cell Thera- pies .- Integrative NanoTherapeutics.- Clinical Ap- plications.- Bio- and Memory Materials.- Scaffolds and Gels .- Tissue Engineering.- Neural [..]

Fields of interest Biomedical Engineering; Cell Biology; Soft Matter, Complex Fluids; Structural Mechanics

Target groups Researchers and graduate students

Type of publication Monograph

Due January 2008

2008. Approx. 500 p. Hardcover

99,95 € ISBN 978-3-540-75408-4 springer.com/booksellers Life Science 9

J. Audet (Ed.) A.Y. Avidan, UCLA, Los Angeles, CA, USA (Ed.) J. Azuma, Osaka University, Osaka, Japan (Ed.)

Regenerative Medicine Sleep, Movement Disorders, and Taurine 7 Dopamine

Taurine (2-aminoethanesulfonic acid) is an enig- Fields of interest matic compound abounding in animal tissues. It is Sleep, Movement Disorders, and Dopamine will Biotechnology present at relatively high concentrations in all electri- be divided into five parts, each detailing a unique cally excitable tissues such as brain, sensory organs, theme: (I) physiology of the dopaminergic system; Type of publication heart, and muscle, and in certain endocrine glands. (II) role of DA in PLMD and RLS; (III) DA hypo- Contributed volume Some of its physiological functions are already es- function as a contributor to RBD; (IV) imaging stud- tablished, for example as an essential nutrient dur- ies in DA deficient states; and finally (V) the down- Due January 2009 ing development and as a neuromodulator or os- side of DA treatment underlying the fine balance be- molyte, but the cellular mechanisms are still mostly tween sleep and wakefulness. Each part will be di- a matter of conjecture. Moreover, there are a num- 2008. Approx. 400 p. (Methods in Molecular Biology, Preliminary vided into several chapters further exploring and re- ber of other putative functions of taurine less well entry 2257) Hardcover viewing recent data as detailed in the table of con- known at present. Taurine 7 contains the proceed- tents. 74,95 € ings of the 16th International Taurine Meeting. This ISBN 978-1-58829-797-6 Contents meeting is a multidisciplinary symposium, Neurobiology of Dopaminergic Modulation of Be- with participants presenting different fields of bio- havioral States.- The Two Faces of Eve: Dopamine's logical science. This volume focuses on all aspects of Modulation of Wakefulness and Sleep, Emerging taurine research from immunology and its effect on Views from an Unlikely Source: Parkinson’s disease.- health to chemistry and biochemistry, including fu- Restless Legs Syndrome: Revisiting the Dopamine ture clinical applications. Hypothesis from the Spinal Cord Perspective.- Features Parkinson’s Disease and Restless Legs Syndrome: A The book summarizes the most recent research find- Dopaminergic Bridge.- Treatment of Restless Legs ings obtained during the last three to four years since Syndrome with Dopamine Agonists. The Benefits.- the publication of the preceding book on taurine. Dopamine D2 Receptor Alteration in Patients with The present volume is the newest member of Periodic leg Movements.- The Neurophysiology of the series of books on taurine highlighted in AEMB. the Alternating Leg Muscle Activation (ALMA) during sleep: [..] Contents Immunology, immunohistochemistry, infectious dis- Fields of interest ease.- Chemistry, biochemistry and metabolism of Neurosciences; Neurobiology; Pharmacology/Toxi- taurine.- Nutritional aspects of taurine.- Transport cology; Neurology; Human Physiology mechanisms of taurine.- Osmotic actions of taurine.- Target groups Taurine in the liver and pancreas.- Taurine and the Sleep Specialists (clinicians, researchers and cardiovascular system.- Taurine and the renal sys- trainees), neuroscientists, neurologists, psychiatrists, tem.- Taurine and the musculoskeletal system.- Tau- sleep technologists, internists, pharmacists, psychol- rine in the central nervous system.- Antioxidant ac- ogists, pulmonologists tions of taurine.- Anti-ischemic actions of taurine.- Pharmacology of taurine derivatives. Type of publication Contributed volume Fields of interest Biochemistry, general; Pharmacology/Toxicology; Human Physiology; Neurosciences; Immunology Due July 2008 Target groups 2008. Approx. 500 p. (Contemporary Clinical Neuroscience) Hard- Researchers in molecular biology, pharmacology, cover physiology, immunology, neuroscience, neurology, and cardiology 122,45 € ISBN 978-1-60327-189-9 Type of publication Proceedings

Due July 2008

2008. Approx. 500 p. (Advances in Experimental Medicine and Biology, Preliminary entry 831) Hardcover

173,25 € ISBN 978-0-387-75680-6 10 Life Science springer.com/booksellers

N. Balaban, Tufts University, North Grafton, MA, USA (Ed.) M. Barbieri, University of Ferrara, Italy (Ed.) R. Bargagli, University of Siena, Italy

Control of Biofilm Infections by The Codes of Life Antarctic Ecosystems

Signal Manipulation The Rules of Macroevolution Environmental Contamination, Climate Change, and Human Impact

The medical miracle of antibiotics is being eroded Building on a range of disciplines – from biology and by the emergence and spread of bacterial drug re- anthropology to philosophy and linguistics – this Choice Outstanding Title! (January 2006) The im- sistance. This is compounded by the fact that bac- book draws on the expertise of leading names in the age of Antarctica as a symbol of the last great wilder- terial biofilms are believed to be a common cause study of organic, mental and cultural codes brought ness and pristine environment has changed consid- of persistent infections, when because growing in together by the emerging discipline of biosemiotics. erably in the last two decades. Environmental prob- biofilms, bacteria are protected from the host’s im- The book’s 18 chapters present a range of experi- lems such as the ozone hole and the break-up of ice- mune response and from antibiotics. In addition, mental evidence which suggests that the genetic code shelves have shown that Antarctica is inextricably biofilms may spawn systemic infections by sloughing was only the first in a long series of organic codes, linked to global processes and exposed to the impact of planktonic bacteria, leading to dissemination, bac- and that it has been the appearance of new codes – of human activities in the rest of the world. This vol- teremia, sepsis, and death. The number of patients organic, mental and cultural – that paved the way for ume provides an overview of climate change data, its affected by and dying from what can be considered the major transitions in the history of life. While the effects on the structure and functioning of Antarctic as a “biofilm disease” is higher than heart disease existence of many organic codes has been proposed ecosystems, and the occurrence and cycling of per- and cancer combined, making medical biofilms the since the 1980s, this volume represents the first mul- sistent contaminants. It discusses the unique physi- biggest single disease that the healthcare system ti-authored attempt to deal with the range of codes co-chemical characteristics of the Antarctic environ- is facing today.This book describes the molecular relevant to life, and to reveal the ubiquitous role of ment, ecophysiological adaptations of terrestrial and mechanisms of cell-to-cell communication among coding mechanisms in both organic and mental evo- marine organisms, the transfer of contaminants in bacterial cells in a biofilm, the development of an- lution. This creates the conditions for a synthesis of pelagic and neritic food chains and the possible con- tibiofilm inhibitors, like quorum-sensing inhibitors, biology and linguistics that finally overcomes the old sequences for animals at higher trophic levels. The and the use of biofilm inhibitors to prevent and treat divide between nature and culture. The book will ap- text concludes with possible future scenarios of cli- bacterial infections in humans and other animals. peal to all [..] mate change and atmospheric contamination and the role of Antarctic organisms in the [..] Features Features Provides novel approaches and solutions to biofilm First multi-authored book on organic codes Genetic Features infections that are largly untreatable by using con- code was only first of a long series of organic codes Provides an overview of the unique Antarctic envi- ventional approaches and antibiotics Finally the rules of macroevolution looked for by ronment, the functioning of terrestrial and aquatic generations of biologists Organic codes are the key ecosystems, and the occurrence and cycling of persis- Fields of interest to understanding the major transitions of life histo- tent contaminants Discusses the role of Antarctic re- Microbiology; Bacteriology; Cell Biology; Bioinfor- ry Evolution took place by natural selection, conven- search for the protection of the global environment matics; Proteomics; Microbial Ecology tions Mental, cultural codes came after a three-billion-year history of organic codes Contents Target groups Antartica: geomorphology and climate trends.- Libraries, institutes, scientists Contents Glacial, terrestrial and freshwater ecosystems.- The Editorial.- 1. Codes of biosequences.- 2. The mecha- Southern Ocean environment: anthropogenic im- Type of publication nisms of evolution.- 3. Catalytic propensity of amino pact and climate change.- Persistent contaminants Contributed volume acids and the origins of the genetic code and pro- in the Antarctic atmosphere.- Anthropogenic con- teins.- 4. Why the genetic code originated.- 5. Self- taminants in snow, terrestrial ecosystems and inland Due December 2007 referential formation of the genetic system.- 6. The waters.- Trace elements in Antarctic seawater and mathematical structure of the genetic code.- 7. The sediments and polluted coastal ecosystems.- Heavy 2008. XV, 170 p. 56 illus., 13 in color. (Springer Series on Biofilms, arithmetical origin of the genetic code.- 8. Protein metals and POPs in Antarctic marine food chains.- Vol. 2) Hardcover linguistics and the modular code of the cytoskele- Climate change, anthropogenic impact and environ- ton.- 9. A lipid-based code in nuclear signalling.- 10. mental research in Antarctica: a perspective.- Refer- 89,95 € Biological information transfer beyond the genet- ences.- Subject index. ISBN 978-3-540-73852-7 ic code: the sugar code.- 11. The immune self code: from correspondence to [..] Fields of interest Ecology; Atmospheric Protection/Air Quality Con- Fields of interest trol/Air Pollution; Climate Change; Biogeosciences; Evolutionary Biology; Philosophy of Biology; Coding Nature Conservation; Environmental Management and Information Theory; Interdisciplinary Studies; Semantics Target groups Researchers, environmental managers, conservation- Target groups ists Biologists of all fields, ecologists, anthropologists, psychologists, philosophers, linguists, researchers in Type of publication the history of science, in the origin of life, in artificial Monograph life and artificial intelligence, students of information theory and communication technology Due October 2007

Type of publication 2008. XIX, 395 p. 50 illus. (Ecological Studies, Vol. 175) Softcover Contributed volume 54,95 € Due October 2007 ISBN 978-3-540-74005-6

2008. Approx. XX, 438 p. 8 color illus. (Biosemiotics, Vol. 1) Hard- cover

139,95 € ISBN 978-1-4020-6339-8 springer.com/booksellers Life Science 11

S. Barik, University of South Alabama, Mobile, AL, USA (Ed.) C.J. Barker, Karolinska University Hospital Solna, Stockholm, Swe- den (Ed.) RNAi Inositol Phosphates and Lipids Design and Application

RNA interference (RNAi), in which RNA silences Fields of interest RNA, is the most recent discovery to revolutionize Life Sciences, general the study of biology. In RNAi: Design and Applications, leaders in the field contribute state- Type of publication of-the-art, easy to follow methods and bench Contributed volume protocols designed for practical, everyday use of RNAi in biological research. Divided into Due April 2009 two parts, this comprehensive volume covers fundamentals including designs of RNAi, biochemical assay protocols for the major components of RNAi, 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary entry 2203) Hardcover and study of potential off-target effects, followed by an extensive section covering various applica- 76,65 € tions of RNAi in diverse model organisms and sys- ISBN 978-1-60327-174-5 tems, from antiviral and anticancer applications to altering flower color in plants. Cutting edge and clearly written, RNAi: Design and Applications enables a researcher with standard molecular biological training to perform major RNAi-related experiments and contribute to this revolutionary, growing field.

Features Step-by-step instructions in a laboratory bench protocol format Detailed lists of the necessary equipment and reagents Tips on troubleshooting from actual experience of the experts Example data set in most chapters Variety of organisms and applications

Contents Principles of Dicer Substrate (D-siRNA) Design and Function.- Expression, Purification, and Analysis of Recombinant Drosophila Dicer-1 and Dicer-2 Enzymes.- In vitro RNA Cleavage Assay for Arg- onaute-Family Proteins.- Identifying siRNA-Induced Off-Targets by Microarray Analysis.- Hydrodynam- ic Delivery of siRNA in a Mouse Model of Sepsis.- Nasal Delivery of siRNA.- RNA Interference as a Ge- netic Tool in Trypanosomes.- Lentivirus-Mediat- ed RNA Interference in Mammalian Neurons.- Si- lencing Genes by RNA Interference in the Protozoan Parasite Entamoeba histolytica.- Use of RNAi in C. elegans.- [..]

Fields of interest Biochemistry, general; Human Genetics; Molecular Medicine; Cell Biology

Target groups Geneticists, molecular and cellular biologists

Type of publication Contributed volume

Due May 2008

2008. Approx. 290 p. 45 illus. 3 in color (Methods in Molecular Biology, Vol. 442) Hardcover

79,95 € ISBN 978-1-58829-874-4 springer.com/booksellers Life Science 12

M.R. Barnes, GlaxoSmithKline Services Unlimited, Brentford, Mid- G.W. Barrett, University of Georgia, Athens, GA, USA; G.A. Feld- H.-J. Barth, University of Regensburg, Germany (Ed.) dlesex, UK; G. Breen, MRC Social Genetic and Developmental Psy- hamer, Southern Illinois University, Carbondale, IL, USA (Eds.) chiatry Centre, London, UK (Eds.) Protecting the Gulf's Marine The Golden Mouse Genetic Variation Ecosystems from Pollution Ecology and Conservation

The study of genetic variation is a multi-step pro- This volume reviews present sources and levels of cess with iterative involvement of bioinformatics and Ecology of the Golden Mouse will interest students pollution in The Gulf, assesses their causes and ef- bench methods. This volume attempts to reflect this, and professionals in ecology, conservation biology, fects on biota and ecosystems, and identifies preven- focusing on each of these stages in detail as it applies mammalogy, and wildlife management. The golden tive and remedial measures reducing levels of pollu- to different forms of genetic variation. mouse is used as a model to explore conceptual is- tion and mitigating adverse impacts. It is organized sues in ecology across all levels of organization from in 5 sections: Part I: Environmental setting of The Contents organism to landscape, integrating reductionist and Gulf; Part II: Present sources and levels of pollution; Introduction.- Genome Visualisation.- HapMap.- holistic ecological science. Through intensive study Part III: Effects of marine pollution on ecosystems Cytogenetic analysis methods.- Cytogenetic Infor- of a single species, the authors demonstrate biolog- and biota; Part IV: Preventing and combating ma- matics.- Copy number variation (CNV) analysis – ical and ecological information applicable to many rine pollution; Part V: Overall conclusions and rec- Somatic/Cancer.- Copy number variation (CNV) fields, including conservation and resource man- ommendations. analysis – Germline.- CNV informatics and databas- agement. At the individual level, the authors discuss es.- Microsatellite analysis methods.- Microsatel- topics such as natural history, systematics, behavior, Features lite Informatics and databases.- SNP genotyping nest construction, home range, and movements, as Supported by UNESCO, Doha methods.- SNP informatics and databases.- Whole well as the unique bioenergetic strategy of the gold- Contents genome resequencing for the analysis of variation.- en mouse, their population dynamics, growth, and From the contents: Part I: Environmental setting Mitochondrial analysis.- Mitochondrial informatics.- genetics. At the community level, coexistence with of The Gulf.- Part II: Present sources and levels of Epigenetic Analysis methods.- Epigenetic Informat- sympatric species, competitive interactions, mutual- pollution.- Part III: Effects of marine pollution on ics.- Evaluating the impact of variation.- Expression ism, parasitism, and the benefits of semi-arboreal liv- ecosystems and biota.- Part IV: Preventing and com- as [..] ing are discussed. Chapters also provide direction for further research by including [..] bating marine pollution.- Part V: Overall conclusions Fields of interest and recommendations. Cell Biology; Human Genetics Features Provides an in-depth discussion of the golden mouse Fields of interest Type of publication at levels of organization from individual to landscape Industrial Pollution Prevention; Ecosystems; Marine Contributed volume Uses the study of a single species as a model to ex- Ecology; Monitoring/Environmental Analysis/Envi- plore broad conceptual issues in ecology Presents ronmental Ecotoxicology; Nature Conservation questions for future research in integrative ecosys- Due March 2009 Target groups tem studies Scientific libraries, environmental institutions; re- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Contents searchers in ecology, environmental sciences entry 2233) Hardcover Foreword.- Preface.- Acknowledgments.- Introduc- Type of publication tion: The Golden Mouse: A Levels-of-Organization 76,65 € Monograph ISBN 978-1-60327-366-4 Perspective.- The Golden Mouse: Taxonomy and Natural History.- Levels of Organization: Population Ecology of the Golden Mouse.- Community Ecol- Due December 2007 ogy of the Golden Mouse.- Ecosystem Ecology of the Golden Mouse.- Landscape Ecology of the Gold- 2007. Approx. 350 p. Hardcover en Mouse.- Transcending Processes: Relative Abun- dance and Conservation: Is the Golden Mouse a Rare 79,90 € Species?- The Golden Mouse: A Model of Energetic ISBN 978-3-7643-7946-9 Efficiency.- Nesting Ecology of the Golden Mouse: An Oikos Engineer.- Ectoparasites, Bots, and Vec- tor-Borne [..]

Fields of interest Animal Ecology; Nature Conservation; Population Ecology; Ecosystems; Zoology; Environmental Man- agement

Target groups Students, ecologists, wildlife managers

Type of publication Professional book

Due December 2007

2008. Approx. 270 p. Hardcover

69,95 € ISBN 978-0-387-33665-7 springer.com/booksellers Life Science 13

H.W. Bass, Florida State University, Tallahassee, FL, USA; J.A. E. Beck, University of Bayreuth, Germany; J. Bendix, University of N.H. Bergman, University of Michigan, Ann Arbor, MI, USA (Ed.) Birchler, University of Missouri, Columbia, MO, USA (Eds.) Marburg, Germany; I. Kottke, University of Tübingen, Germany; F. Makeschin, Dresden University of Technology, Tharandt, Ger- many; R. Mosandl, Technical University of Munich, Freising, Ger- Comparative Genomics Plant Cytogenetics many (Eds.) Volume 1 Genome Structure and Chromosome Function Gradients in a Tropical Mountain

Ecosystem of Ecuador This volume provides a collection of robust protocols Plant cytogenetics comprises a topic of broad inter- for molecular biologists studying comparative ge- est and increasing importance in plant science. In nomics. Given the tremendous increase in available keeping with the exciting advances in plant genetics A tropical mountain ecosystem in one of the biosequence data over the past ten years, this volume and genomics, we believe that a comprehensive and "hottest" biodiversity hotspots worldwide was inves- is timely, comprehensive, and novel. The volume is up-to-date reference on plant cytogenetics would be tigated by some 30 research teams of numerous dis- intended for molecular biologists, biochemists and of great interest and value for researchers, instruc- ciplines in the natural and social sciences. Ecosys- geneticists. tors, and students with interests in genetics, plant tem analysis followed two gradients: an altitudinal biology, and plant genomics. The field of cytoge- Features gradient and a gradient of land-use intensity and netics is currently expanding at the same fast pace Provides a collection of robust protocols for molecu- ecosystem regeneration, respectively. This volume that genome technologies are moving but no reli- lar biologists studying comparative genomics Each addresses a multitude of ecologically relevant as- able reference exists that captures the current state chapter includes detailed instructions for using a pects: macro- and microclimate; physics, chemistry of progress. The goal then of the proposed reference particular tool or method and an introduction to and biology of soils; water relations, matter turnover is to provide a scholarly and timely review of plant the theory behind the technique A Notes section at and nutrient availability; plant growth and biomass cytogenetics that covers traditional aspects of plant the end of each chapter that guides the user through partitioning; floral composition and plant life forms; cytogenetics together with the emerging and exciting commonly encountered difficulties, providing key vegetation structure and dynamics; organismic in- new areas of genomics, epigenetics, evolution, and tips for using the method most efficiently teractions, diversity and population biology of birds, chromosome engineering. Advances in plant genet- moths and microarthropods; forest management, ics and genomics are driving major changes in how Contents and reforestation with indigenous species; ethnob- we view fundamental concepts such as gene regula- Comparative analysis and visualization of genom- otanical and social aspects. New hypotheses are pre- tion, genome organization, and plant [..] ic sequences using VISTA Browser and associated sented with regard to biodiversity and ecosystem computational tools.- Comparative Genomic Anal- Features functioning, as well as sustainable management of an ysis Using the UCSC Genome Browser.- Compar- Presents the origin and the use of nomenclature, and ecosystem in a biodiversity hotspot. ative Genome Analysis in the Integrated Microbial the key concepts in cytogenetics Discusses aspects of Genomes (IMG) System.- WebACT: An Online Features structural genomics and specifically treat the analy- Genome Comparison Suite.- GenColors: Annotation A comprehensive study on one of the "hottest"" bio- ses of the plant genome structure, the use of cytoge- and Comparative Genomics of Prokaryotes made diversity hotspots worldwide netic techniques to develop maps, karyotypes, and easy.- Comparative Microbial Genome Visualization associated resources, and the development of new Contents Using GenomeViz.- BugView: A Tool for Genome technologies Looks at functional cytogenetics and Part I Introduction.- Part II Gradients in ecosys- Visualization and Comparison.- CGAS: Compar- chromosome processes with emphasis on cytogenetic tem analysis.- Part III The altitudinal gradient.- Part ative Genome Annotation System.- BLAST Quick [..] III.1 Gradual changes along the altitudinal gradient.- Start: An Example-driven Web-based BLAST [..] Part III.2 Processes along and within the gradient.- Contents Fields of interest Part III.3 Gradient heterogeneities.- Part III.3.A Spa- Polyploidy and aneuploidy.- Chromosomal rear- Human Genetics; Cell Biology; Biochemistry, general tial heterogeneities.- Part III.3.B Temporal hetero- rangements, Inversions and translocations.- Chro- geneities.- Part IV Gradients of disturbance Part IV.1 mosome additions, substitutions, and deletion lines.- Target groups Natural disturbances.- Part IV.2 Disturbance by hu- B chromosomes.- Karyotypes.- Molecular cytology, Molecular biologists, biochemists, geneticists man activities.- Part IV.2.A Planned disturbance as tools for the 21st century.- Cytogenetic FISH map- strategies for a sustainable use.- Part IV.2.B Distur- ping.- High-resolution cytogenetics.- Defining cen- Type of publication bance by clearing the forest.- Part V Gradients of Re- tromeres; location, function, and dynamics.- Het- Contributed volume generation.- [..] erochromatin.- Integrating cytogenetic data into genome databases.- Functional architecture of the Fields of interest Due November 2007 plant nucleus.- Cytology of meiotic chromosome be- Ecosystems; Biodiversity; Plant Ecology; Animal havior.- Evolutionary comparative cytogenetics.- Cy- Ecology; Forestry Management; Environmental 2007. Approx. 584 p. 147 illus. (Methods in Molecular Biology, tology of chromatin modifications and epigenetics.- Management Vol. 395) Hardcover [..] Target groups 99,95 € Fields of interest Researchers and advanced students ISBN 978-1-58829-693-1 Plant Genetics & Genomics; Plant Sciences Type of publication Target groups Reference work researchers, scientists, and academics in the field of plant genetics and genomics Due January 2008 Type of publication Contributed volume 2008. Approx. 540 p. 148 illus., 32 in color (Ecological Studies, Vol. 198) Hardcover Due August 2008 179,95 € ISBN 978-3-540-73525-0 2008. Approx. 500 p. (Plant Genetics and Genomics: Crops and Models, Vol. 5) Hardcover

137,85 € ISBN 978-0-387-70868-3 14 Life Science springer.com/booksellers

N.H. Bergman, University of Michigan, Ann Arbor, MI, USA (Ed.) A.A. Berryman, Washington State University, Pullman, U.S.A.; P. A.K. Bhunia, Purdue University, West Lafayette, IN, USA Kindlmann, Biodiversity Research Centre, Institute of Systems Biology and Ecology AS CR, Ceske Budejovice, Czech Republic Comparative Genomics Foodborne Microbial Pathogens

Volume 2 Population Systems Mechanisms and Pathogenesis

A General Introduction

This volume provides a collection of robust protocols Undoubtedly in the past 10-20 years, impact of food- for molecular biologists studying comparative ge- borne pathogens has been overwhelming because of nomics. Given the tremendous increase in available This book is concerned with the general principles high rate of fatalities, illnesses, and the fear of being biosequence data over the past ten years, this volume and theories of population ecology, based on the idea exposed to incurable infective agents or toxins. Rapid is timely, comprehensive, and novel. The volume is that the rules governing the dynamics of populations growth in the centralized food production indus- intended for molecular biologists, biochemists and are relatively simple, and that the rich behavior we tries, aggressive agricultural practices and changes in geneticists. observe in nature is a consequence of the structure of food consumption habits are contributing factors for the system rather than of the complexity of the un- the emergence of increased foodborne infections by Features derlying rules. From this perspective, the dynamic new or old pathogens resulting in several outbreaks, Provides a collection of robust protocols for molecu- behavior of singel-species populations is examined product recalls and economic losses. These events lar biologists studying comparative genomics Each and an elementary feedback model of the population prompted increased research activities to understand chapter includes detailed instructions for using a system is developed. This single-species model is re- the pathogens and their pathogenic mechanisms, and particular tool or method and an introduction to fined and generalized by examining the mechanisms prevention and control strategies. Modern molecular the theory behind the technique A Notes section at of population regulation. Graphical procedures are tools also facilitated our understanding of the func- the end of each chapter that guides the user through developed for evaluating the behavior of populations tion and regulations of virulent or other accessory commonly encountered difficulties, providing key inhabiting variable environments, which are then genes. Above all, the complete genome sequence of tips for using the method most efficiently applied to the analysis of interactions between two several important foodborne pathogens helped un- species. Finally, spatial effects on population behav- ravel the molecular basis of pathogenesis. Foodborne Contents ior and communities composed of many interacting Bacterial Pathogens: Mechanisms and Pathogenisis Computational Prediction of Domain Interactions.- species are examined. will be a graduate level [..] DomainTeam: Synteny of domains is a new approach in comparative genomics.- Inference of gene Features Features function based on gene fusion events: the Rosetta This book presents a completely unique approach, For the first time a book will link fooborne illness Stone method.- Pfam: A domain-centric method for based on a simple set of general rules governing the and immunology. This textbook will combine the analyzing proteins and proteomes.- InterPro and In- population interactions host parasite interaction to a level where the readers terProScan-Tools for Protein Sequence Classification would have better appreciation for the disease mech- Fields of interest and Comparison.- Gene Annotation and Pathway anism with up-to-date information on molecular and Zoology; Ecology; Mathematical Biology in General Mapping in KEGG.- Ortholog Detection using the cellular mechanism of several major foodborne bac- Smallest Distance Algorithm.- Finding Conserved Target groups terial pathogens, virulence genes and their regulation Gene Order Across Multiple Genomes.- Analysis of Undergraduate and graduate students, practicing in the host or the food environment, pathogenicity Genome Rearrangement by Block-Interchanges.- ecologists. [..] Analyzing [..] Type of publication Contents Fields of interest Graduate/advanced undergraduate textbook Introduction to Foodborne Pathogens.- Biology Human Genetics; Cell Biology; Biochemistry, general of Microbes Associated with Food.- Host Defense against Foodborne Pathogens.- General Mechanism Target groups Due December 2007 of Pathogenesis.- Animal and Cell Culture Models Molecular biologists, biochemists, geneticists to Study Foodborne Pathogen Interaction.- Staphy- Originally published by Springer US, 1981 lococcus aureus.- Bacillus cereus and Bacillus an- Type of publication thracis.- Clostridium botulinum and Clostridium Contributed volume 2008. Hardcover perfringens.- Listeria monocytogenes.- Escherichia coli.- Salmonella enterica.- Campylocbacter and Due November 2007 35,00 € Arcobacter.- Yersinia enterocolitica and Yersinia ISBN 978-1-4020-6818-8 pestis.- Vibrio cholerae, Vibrio parahaemolyticus, 2007. 464 p. 151 illus., 1 in color. (Methods in Molecular Biology, Vibrio vulnificus.- Shigella species.- Index. Vol. 396) Hardcover Fields of interest 79,95 € Food Science; Bacteriology; Immunology; Medicine, ISBN 978-1-934115-37-4 general

Target groups Graduate courses, upper level undergrad students, food microbiologists, animal scientists, veterinary scientists, possibly medical microbiologists.

Type of publication Graduate/advanced undergraduate textbook

Due January 2008

2008. Approx. 220 p. (Food Science Texts Series) Hardcover

53,90 € ISBN 978-0-387-74536-7 springer.com/booksellers Life Science 15

L.O. Björn, Lund University, Lund, Sweden (Ed.) R. Blanton, Purdue University, West Lafayette, IN, USA; L. Fargher, J.H. Bock, University of Colorado, Boulder, CO, USA; D.O. Norris, Purdue University, West Lafayette, IN, USA University of Colorado, Boulder, CO, USA Photobiology Collective Action in the Formation Handbook of Forensic Botany The Science of Life and Light of Pre-Modern States

This book introduces the forensic scientist to the Photobiology: The Science of Life and Light, Sec- practice of forensic botany by providing technique Anthropological archaeology and other disci- ond edition, is fully updated and offers eight new instructions, reference photos and analysis of digest- plines concerned with the formation of early chapters for a comprehensive look at photobiology. ed plant materials. Because humans cannot digest complex societies are undergoing a theoretical The chapters cover all areas of photobiology, photo- cellulose, plant foods can be traced and identified at shift stemming from the realization that the chemistry, and relationship between light and biolo- various stages of digestion. Using the techniques de- social evolution of complex societies was more var- gy, each with up-to-date references. The chapter au- scribed in this book, the forensic pathologist will be ied and complex than imagined. Given the need for thors (of which seven are new) have very different able to identify the type of plant consumed as well new directions in theory, the book proposes backgrounds, and have produced a truly cross-disci- as whether it was consumed during the victim's last that anthropologists look to political science, espe- plinary treatise. The book starts with the physics and meal. You will also learn to identify toxic and poi- cially the rational choice theory of collective action. chemistry of light, and how to handle light in the lab- sonous plants/herbal products and crime scene plant Collective action theorists propose that state forma- oratory and measure it in the field, the properties of identification. the final section of the book explains tion results from the strategic behavior of rational daylight, and new uses of light in research. It deals how to utilize the botany expertise at colleges, muse- and self-interested actors who make up the polity, in- with the evolution of photosynthesis and with the ums, gardens and botany organizations throughout cluding a political elite and those outside the official mechanisms of its primary steps. Four chapters deal the world. with how organisms use light for their orientation in structure of the state. The theory proposes that the space and time: The biological clock and its resetting form taken by a state will depend on the "bargaining Fields of interest by light, the light-dependent magnetic compass, and power", of rulers and taxpayers. Where tax- Forensic Medicine; Plant Sciences photoperiodism in animals and plants. There are also payers have more resources with which to bar- several medically oriented chapters and two chapters gain, it is predicted that rulers will concede benefits Target groups specifically aimed at [..] to taxpayers and will agree to restrictions on their Forensic scientists, plant biologists power. The authors subject collective [..] Features Type of publication A thorough introduction and research overview to Features Contributed volume the basics of “light science” Biggest collection of in- uses political science theory in researching state formation in prehistoric societies takes ternational experts in the field in one book Chapters Due July 2008 from all areas of photobiology, photochemistry, and a global comparative approach Blanton is one of the relationship between light and biology, each with up- founders of the field of economic and political ar- to-date references Second edition is fully updated chaeology 2008. Approx. 300 p. Hardcover and offers eight new chapters for a comprehensive Contents 89,95 € look at photobiology Introduction The Rise and Demise of Neoevolution- ISBN 978-1-58829-123-3 Contents ist Theory.- The Theory of Collective Action as Ap- Preface.- The Nature of Light and its Interaction plied to Pre-Modern States.- Historical Backgrounds with Matter.- Principles and Nomenclature for the to the Study Regions and the Coded Societies, Part Quantification of Light.- Generation and Control of I: Introduction and East Asia.- Background to State Light.- Measurement of Light.- Light as a Tool for Formation and the Coded Polities in Southeast Asia.- Biologists: Recent Developments.- Terrestrial Day- Background to State Formation and the Coded Poli- light.- Underwater Light.- Action Spectroscopy in ties in South Asia and the Coded Polities .- Back- Biology.- Spectral Tuning in Biology.- The Photo- ground to Sub-Saharan African State Formation.- chemical Reactions in Biological Light Perception Background to State Formation in Western Eurasia and Regulation.- The Diversity of Eye Optics.- The and the Mediterranean/North Africa.- Background Evolution of Photosynthesis and its Environmental to the New World States.- Material and [..] Impact.- Photosynthetic Light-Harvesting, Charge Fields of interest Separation and Photoprotection – The [..] Archaeology; Anthropology; Political Science Fields of interest Type of publication Plant Sciences; Plant Anatomy/Development; Evolu- Monograph tionary Biology; Plant Physiology

Target groups Due December 2007 Graduate students, scientists, and researchers in the field of plant science, biologically interested readers 2008. Approx. 460 p. (Fundamental Issues in Archaeology) Hard- at different levels from undergraduates to professors, cover researchers and medical doctors 91,65 € Type of publication ISBN 978-0-387-73876-5 Contributed volume

Due December 2007

Originally published by Springer Netherlands

2008. Approx. 630 p. Hardcover

149,95 € ISBN 978-0-387-72654-0 16 Life Science springer.com/booksellers

R. Bock, MPI, Potsdam-Golm, Germany (Ed.) V. Bojnanský, A. Fargašová, Comenius University, Bratislava, Slo- I. Bos, University of Wageningen, The Netherlands; P. Caligari, In- vak Republic stituto de Biologia Vegetal y Biotecnologia, Universidad de Talca, Chile Cell and Molecular Biology of Plastids Atlas of Seeds and Fruits of Central and East-European Flora Selection Methods in Plant Breeding The Carpathian Mountains Region The past two decades have witnessed an enormous 2nd Edition progress in our understanding of plastid (chloroplast) biology. Basic principles of plastid biogenesis, The Carpathian flora occurs not only in the genome structure and function, gene expression and Carpathian Mountains, but also in large lowlands Written for plant breeders, researchers and post- its regulation as well as plastid-nuclear interaction extending towards the south, north and east and in- graduate students, this book provides a comprehen- and communication pathways have been elucidated. volves introduced and invading flora of more than sive review of the methods and underlying theoreti- In addition, the possibility to directly alter the genet- 7,500 species. Since the morphological characteris- cal foundations used for selection in plant breeding ic information of the plastid by transformation has tics of the seeds are usually constant they are very programmes. The authors review basic elements of facilitated the study of virtually all aspects of plastid important for determination of systematic units. The population and quantitative genetic theory, and con- biology in vivo and, moreover, has paved the way to present atlas of seeds with nearly 4,800 seed illus- sider in a unique way the tackling of the problems diverse applications of transgenic plastids in biotech- trations is supplemented with detailed seed descrip- presented by soil heterogeneity and intergenotypic nology. The present book provides a comprehensive tions, brief plant descriptions, locality and the na- competition when selecting quantitative characters. overview of our current knowledge on plastid bio- tive source of plants. This publication is unique, both The efficacy of different methods with regard to de- genesis, plastid-nuclear communication, the regula- in its extent – with so many plant seeds from such a veloping new varieties of crops are discussed for dif- tion of plastid gene expression at all levels, and also wide-ranging region – and in the form of its presen- ferent modes of reproduction. This work provides a assesses the state of the art in key technologies, such tation – with such detailed descriptions. sound basis for informed decision making within the as proteomics and chloroplast transformation. Writ- process of a selection programme. ten by recognized experts in the field, it covers plas- Features tid differentiation and division, genome structure Unique both in extent and in the form of presen- Features and function, [..] tation Apart from seed descriptions and illustra- Concise text on population and quantitative genetic tions also introduces short plant descriptions, local- theory Comprehensive treatment of selection meth- Features ity and native sources of plant species Never before ods for qualitative and quantitative traits Extensive Gives up-to-date overview on all aspects of plastids were such detailed descriptions and presentations treatment of problems due to soil heterogeneity and Assesses state-of-the-art key technologies Written by of so many plant seeds (nearly 4,800) from Central intergenotypic competition experts in the field and East-European regions, oriented mainly on the Carpathian region, published Contents Contents Preface.- Preface to the 2nd edition.-1 Introduc- Plastid biogenesis and differentiation.- Structure, Contents tion.-2 Population genetic effects of cross-fertiliza- function, and inheritance of plastid genomes.- DNA I. Introduction.- II. Glossary.- III. Register of the ex- tion.-3 Population genetic effects of inbreeding.-4 replication, recombination, and repair in plastids.- ploited Botanical Gardens (1900-2003).- IV. Types Assortative mating and disassortative mating.-5 Pop- Transcription and transcriptional regulation in plas- of seeds' surfaces.- V. Taxonomy and morphology of ulation genetic effects of selection with regard to sex tids.- Processing, degradation, and polyadenylation seeds.- VI. Literature.- VII. Key of families of Sper- expression.-6 Selection with regard to a trait with of chloroplast transcripts.- RNA splicing and RNA matophyta.- VIII. Index of scientific names. qualitative variation.-7 Random variation of allele editing in chloroplasts.- Translation and translation- frequencies.-8 Components of the phenotypic value al regulation in chloroplasts.- Assembly of protein Fields of interest of traits with quantitative variation.-9 Effects of the complexes in plastids.- Protein stability and degra- Plant Systematics/Taxonomy/Biogeography; Plant mode of reproduction on the expected genotypic val- dation in plastids.- Protein import into plastids.- In- Sciences; Biodiversity; Plant Genetics & Genomics; ue.-10 Effects of the mode of reproduction on the ge- sights into chloroplast proteomics: from basic princi- Forestry; Plant Ecology netic variance.-11 [..] ples to new [..] Target groups Fields of interest Fields of interest Botanists, agriculturists, breeders, nature conserva- Plant Sciences; Genetics and Population Dynamics; Cell Biology; Plant Genetics & Genomics; Plant tors, genetics, staff and management of gene banks, Agriculture Physiology; Biotechnology archaeologists, palaeontologists Target groups Target groups Type of publication Researchers dealing with the inheritance of quantita- Plant molecular biologists Atlas tive traits Students dealing with quantitative aspects of plant breeding Plant breeders dealing with genetic Type of publication improvement in relation to quantitative traits Reference work Due October 2007 Type of publication Due October 2007 2007. XXXVIII, 1050 p. 4800 illus. Hardcover Contributed volume 399,00 € 2008. XX, 524 p., 51 illus., 11 in color. (Topics in Current Genetics, ISBN 978-1-4020-5361-0 Due October 2007 Vol. 19) Hardcover

259,00 € 2007. XII, 456 p. Hardcover ISBN 978-3-540-75375-9 174,95 € ISBN 978-1-4020-6369-5 springer.com/booksellers Life Science 17

A. Bosio, Miltenyi Biotec, Cologne, Germany; B. Gerstmayer, Mil- A. Bostrom, Georgia Institute of Technology, Atlanta, GA, USA; Z. Bosze, Agricultural Biotechnology Center, Gödöllo, Hungary tenyi Biotec, Cologne, Germany (Eds.) S.P. French, Georgia Institute of Technology, Atlanta, GA, USA; (Ed.) S.J. Gottlieb, Georgia Institute of Technology, Atlanta, GA, USA (Eds.) Microarrays in Inflammation Bioactive Components of Milk Risk Assessment, Modeling and Decision Support Microarray technologies have arisen to a robust and Of all food products dairy foods have the most po- widely accepted tool in inflammation research. Al- Strategic Decisions tential concerning functional foods. Therefore, there ready the first microarray publications in 1996 as is a tremendous amount of interest in value-added well as later ground-breaking publications were ded- milk products and the identification of components icated to topics in inflammation research. Since then, in food which have health benefits. Bioactive Com- many opportunities but also hurdles specifically The papers in this volume integrate results from cur- ponents of Milk provides an overview of these de- linked to the application of microarrays to inflam- rent research efforts in earthquake engineering with rived components and their diverse activities includ- mation topics have been envisaged and partly solved. research from the larger risk assessment communi- ing: the stimulation of beneficial microflora, alert- This book summarizes the most advanced technical ty. The authors include risk and hazard researchers ing the immune system to the presence of potential aspects covering all steps for a thorough application from the major U.S. hazard and earthquake centers pathogens and allergens, binding and eliminating of microarrays to inflammation topics – from sam- and some from abroad as well as programmers and toxins, etc. The book is divided into four parts. The ple generation to data analysis. In addition selected analysts from leading insurance and risk assessment first part focuses on bioactive milk lipid components, examples of successful applications of microarrays firms. The introductory chapter provides an histori- which very widely among mammalian species. The in major fields of inflammation research are present- cal overview of the rise of risk assessment in the U.S., second part describes different aspects of biological ed. After reading the book a researcher or clinician with particular emphasis on the role of seismic risk active colostrums and milk proteins and their deriva- should be in the position to plan, perform and anal- assessment. Four key components of risk assessment tives, with special concern on species specific effects. yse or to critically review microarray experiments re- and decision support software are analyzed in de- The third part reviews the production of recombi- lated to inflammation research. tail in the remaining papers: treatment of uncertain- nant human proteins in the milk of livestock animals ty, loss assessment, modeling of seismic mitigation - including ethical issues - and the aims of altering Features strategies, and visualization of risk and uncertainty. milk composition for the benefit [..] Summarizes the most advanced technical aspects The volume lays out a road map for future develop- from sample generation to data analysis Presents ments in risk modeling and decision support and po- Features successful applications of microarrays in major fields sitions earthquake engineering research within the describes the derived components of milk and their of inflammation research Helps to plan, perform and family of risk analysis tools and techniques. diverse activities analyse microarray experiments Contents Contents Contents Introduction.- A Brief History of Seismic Risk As- Foreword.- Milk Lipids: A Source of Bioactive 1 Microarray and inflammation: an introduction.- sessment.- Perspectives on the History of Seismic Molecules: Trans Fatty Acids and Bioactive Lipids in 2 Methods and protocols for the generation of gene Risk Assessment.- Strategic Directions in Seismic Ruminant Milk.- Expression and Nutritional Regula- expression profiles in inflammation research.- 2.1 Modeling: HAZUS® Development and Current Ap- tion of Lipogenic Genes in the Ruminant Lactating Sample preparation: Whole Blood.- Sample prepara- plications for Catastrophe Planning.- Perspectives on Mammary Gland.- Lipophilic Microconstituents of tion: Comparison of PBMCs and blood cell subsets.- Development and Current Applications for Catas- Milk.- Biological Activity of Native Milk Proteins- Sample preparation: Skin.- Sample preparation: Adi- trophe Planning.- Loss Estimation Models and Met- Species Specific Effects: Milk Fat Globule Mem- pose tissue.- Sample preparation: Samples isolated by rics.- Perspectives on Loss Estimation Models and brane Components - A Proteomic Approach.- Milk Fluorescent Activated Cell Sorting (FACS).- Sample Metrics.- Seismic Risk Mitigation Decisions under Lipoprotein Membranes and Their Imperative En- preparation: Samples isolated by Magnetic Activated Uncertainty.- Perspectives on Seismic Risk Mitiga- zymes.- Lactoferrin Structure and Functions.- Milk Cell Sorting (MACS).- Sample preparation: Logistics, tion Decisions under Uncertainty.- Modeling Seis- sCD14: A Soluble Pattern Recognition Recep- storage and shipping of samples.- 2.2 Single and rare mic Mitigation Strategies.- Perspectives on Modeling tor in Milk.- Apoptosis and Tumor Cell Death in Re- cell analysis – amplification [..] [..] sponse to [..]

Fields of interest Fields of interest Fields of interest Immunology; Cell Biology; Pharmacology/Toxicolo- R & D/Technology Policy; Environmental Manage- Food Science; Organic Chemistry gy; Rheumatology; Oncology ment; Environmental Computing/Environmental Modelling; Quality Control, Reliability, Safety and Target groups Target groups Risk; Computer Appl. in Social and Behavioral Sci- scientists working in academic and industrial insti- Scientific libraries; researchers and clinicians from ences; Applied Geosciences tutes inflammation research, immunology, and pharmacology Target groups Type of publication Scientists Contributed volume Type of publication Monograph Type of publication Due December 2007 Monograph

Due May 2008 2008. Approx. 210 p. (Advances in Experimental Medicine and Due December 2007 Biology, Vol. 606) Hardcover 2008. Approx. 260 p. (Progress in Inflammation Research) Hard- cover 2008. XIV, 320 p. 64 illus. (Risk, Governance and Society, Vol. 14) 107,05 € Hardcover ISBN 978-0-387-74086-7 119,00 € ISBN 978-3-7643-8333-6 89,95 € ISBN 978-3-540-71157-5 18 Life Science springer.com/booksellers

J. Braeckman, Gent University, Belgium; J. Verplaetse, Gent Uni- S.-W. Breckle, University of Bielefeld, Germany; A. Yair, Hebrew G. Britton, University of Liverpool, UK; S. Liaaen-Jensen, NTNU, versity, Belgium; J. De Schrijver, Gent University, Belgium (Eds.) University, Jerusalem, Israel; M. Veste, University of Hohenheim, Trondheim, Norway; H. Pfander, CaroteNature, Bern, Switzerland Stuttgart, Germany (Eds.) (Eds.) The Moral Brain Arid Dune Ecosystems Carotenoids Volume 5: Nutrition Essays on the Evolutionary and Neuroscientific Aspects of Morality The Nizzana Sands in the Negev Desert and Health

Sand dune dynamics plays a key role in many arid The Carotenoids book series provides an intro- Features deserts. This volume provides a synthesis of a spe- duction to the fundamental chemistry, detailed ac- This volume offers cutting-edge research in cific sand dune ecosystem, the Nizzana site in the counts of the basic methods used in carotenoid re- moral psychology and a crossover be- Negev Desert. Describing its climate and geophys- search, and critical discussions of the biochemistry, tween different disciplines, including evolutionary ical/geochemical properties of soils, geological his- functions and applications of carotenoids. Volume psychology and neurology. New perspectives tory, flora and fauna, and past/present land-use pat- 5 consists of three parts. Part 1 on nutrition cov- are given on the moral brain with possible implica- terns, it elucidates ecological and geomorphologi- ers carotenoids as dietary sources and supplements tions for criminology, philosophy and moral educa- cal processes and their interrelations, based on long- and their bioavailability. Part 2 discusses actions of tion. A broad range of prominent scientists term monitoring, in situ experiments and satellite carotenoids and practical approaches that are bene- and philosophers offer their expert views on the cur- imagery. Particular attention is drawn to the impact ficial to human health, like epidemiology and inter- rent accomplishments and [..] of the topsoil biological crust in controlling water vention trials, in vitro studies and studies of anti-oxi- availability at local/regional scales. The interdisci- dant and pro-oxidant effects. Part 3 describes protec- Fields of interest plinary approach adopted in this case study offers a tive effects of carotenoids against diseases, like can- Neurosciences; Evolutionary Biology; Philosophy; good example of a highly complex and dynamic sys- cer, Coronary Heart Disease, eye and skin diseases, Ethics; Philosophy of Medicine; Philosophy of Mind tem, which could easily be applied to other sandy and effects on the immune system. ecosystems. This is a valuable source of information Type of publication for soil ecologists and microbiologists, conservation Features Contributed volume biologists, desert ecologists and geographers, geo- Biological aspects of Carotenoids are covered Use morphologists, soil scientists and climatologists, lec- of carotenoids against diseases is discussed (e.g. Due October 2007 turers, policy makers and others [..] Cancer, Coronary Heart Disease, eye and skin diseases, immunological diseases) To be used in conjunction with the Carotenoids book series and the 2008. Hardcover Features A case study in the Negev desert valid also for other Carotenoids Handbook 92,95 € sandy ecosystems An interdisciplinary investigation ISBN 978-1-4020-6286-5 of a highly complex and dynamic ecosystem Discuss- Contents es the obtained data also regarding global climate Part A: Nutrition: Dietary sources.- Supplements.- change Bioavailability.- Beta, beta-Carotene et al as provita- min A.- Part B: Carotenoids and health: practical ap- Contents proaches.- Epidemiology and intervention trials.- In The volume consists of 31 chapters. It starts with vitro studies.- Studies of antioxidant and prooxidant a General Introduction, which is followed by four effects.- Part C: Carotenoids against disease: Cancer.- Parts: Part A: The NW Negev.- Part B: Ecosystem Coronary heart disease.- The eye.- The skin.- The Patterns.- Part C: Ecosystem Processes.- Part D: Re- immune system.- Overall evaluation of carotenoids search Perspectives/Synthesis and General Conclu- in nutrition and health. sions. Fields of interest Fields of interest Chemistry/Food Science, general; Food Science; Hu- Ecology; Soil Science & Conservation; Biogeo- man Physiology; Immunology; Pharmacology/Toxi- sciences; Climate Change; Geoecology/Natural Pro- cology; Nutrition cesses; Environmental Management Target groups Target groups Researchers, clinicians, scientific libraries, food in- Researchers, lecturers, advanced students, and policy dustry, biotech industry, pharmaceutical industry makers Type of publication Type of publication Monograph Contributed volume Due March 2008 Due February 2008 2008. Approx. 350 p. (Carotenoids, Vol. 5) Hardcover 2008. Approx. 450 p. 214 illus. (Ecological Studies, Vol. 200) Hard- cover 89,90 € ISBN 978-3-7643-7500-3 159,95 € ISBN 978-3-540-75497-8 springer.com/booksellers Life Science 19

M. Brown, Science Systems and Applications, NASA-Goddard, K.J. Bundy, Tulane University, New Orleans, LA, USA K.D. Bunting, Case Western Reserve University, Cleveland, OH, Space Flight Center; R. Chourlarton, Famine Early Warning Sys- USA (Ed.) tem Network, Washington DC Fundamentals of Biomaterials Hematopoietic Stem Cell Protocols The Famine Early Warning Systems Science and Applications and Remote Sensing Data With new technologies emerging and old technolo- Over the past two decades, the field of biomateri- gies being reimagined, the field of hematopoietic als has rapidly matured from a nascent, embryon- This book describes the interdisciplinary work of stem cell (HSC) research continues to grow rapid- ic discipline to one characterized by a firm base of USAID's Famine Early Warning System (FEWS ly in pursuit of improved therapies for many blood scientific and engineering knowledge. This founda- NET) and its influence on methodological and devel- diseases. Updating and building upon the thorough tion now offers the potential for revolutionary break- opment policies in the US. FEWS NET operational first edition's foundation, Hematopoietic Stem Cell throughs in materials used for making surgical im- needs have driven science in biophysical remote Protocols, Second Edition provides up-to-date pro- plants, with consequent dramatic, positive impact on sensing applications through its collaboration with tocols developed in the HSC field. A team of lead- human health. This new text, aimed at bioengineer- NASA, NOAA, USGS and USDA, and socio-eco- ing researchers supply this volume with in-depth, ing students who have already has taken a course on nomic methodologies through its involvement with readily reproducible methods for effective character- the fundamentals of materials science, aims to stress USAID, UN WFP and numerous international non- ization of HSC and their developmental potential. the latest thinking about materials for use in vivo governmental organizations such as Save the Chil- An introductory chapter also hints at potential tech- as well as summarizing and explaining the require- dren, Oxfam and others. The book describes FEWS niques that may develop in the future. Following the ments and characteristics of successful biomaterials. NET's systems, methods and presents several illus- format of the successful Methods in Molecular Biol- The book achieves a balance between engineering trative case studies that will demonstrate the integra- ogy™ series, each protocol offers step-by-step labora- analysis and pertinent biological and physiological tion of both physical and social science disciplines in tory instructions, lists of the necessary equipment, fundamentals, between chemical and mechanical as- its work. and tips on troubleshooting and avoiding known pit- pects of in vivo implant service, and between the dif- falls. Essential for the laboratory-based researcher, Features ferent material classes (polymers, ceramics, metals Hematopoietic Stem Cell Protocols, Second Edition Truly interdisciplinary in that it describes both the and composites). is a much needed technical resource in the [..] remote sensing applications and socio-economic Contents methodologies of early warning systems Will bring Features I. INTRODUCTION. 1. The Modern Field of Bio- the work of USAID's Famine Early warning System Provides detailed flow cytometry protocols for thor- materials - synergistic Interaction between Engineer- Network (FEWS NET) into the public domain Suit- ough analysis of enriched HSC populations Offers ing and Life Science.- II. FUNDAMENTAL CON- able for course use by students and scholars a variety of transplantation approaches to measure CEPTS. 2. The Various Classes of Implant Materials. HSC function in vivo Details retroviral and lentiviral Fields of interest 3. The Tissue Biomaterials Interface. 4. Basic Aspects transduction procedures and analysis of integration Environmental Management; Remote Sensing/Pho- of Biocompatibility.- III. ISSUES RELATED TO IM- sites Describes assays using embryonic and adult tis- togrammetry; Meteorology/Climatology; Climate PLANT DESIGN. 5. Fundamentals of Implant De- sues to derive HSC Change; Physical Geography; Human Geography sign. 6. Characteristics of the in vivo Service Envi- ronment. 7. Design and Use of Implants in Various Contents Target groups Surgical Specialties. 8. Manufacturing Considera- The Expanding Tool Kit for Hematopoietic Stem Researchers and graduate students in physical geog- tions. 9. Testing and Qualification of New Biomateri- Cell Research.- Isolation of Quiescent Murine raphy and remote sensing applications as well as in als for in vivo Service. 10. Tissue Engineering and [..] Hematopoietic Stem cells by Homing Properties.- social, environmental sciences and policy makers in Mobilization of Hematopoietic Stem and Progen- the respective fields. Fields of interest itor cells (HSPC) in Mice.- Transmigration of Hu- Biomaterials; Biotechnology; Biomedical Engineer- man CD34+ cells.- Flow Cytometry Based Cell Cy- Type of publication ing; Biomedicine general; Life Sciences, general cle Measurement of Mouse Hematopoietic Stem and Monograph Progenitor Cells.- Analysis of Apoptosis in HSC by Target groups Flow Cytometry.- In vitro Hematopoietic Differ- Upper div. undergrads, graduate students Due March 2008 entiation of Murine Embryonic Stem (ES) Cells.- Type of publication Hematopoietic Development of Human Embryonic Graduate/advanced undergraduate textbook Stem Cells in Culture.- In vitro Human T Cell Devel- 2008. Approx. 350 p. Hardcover opment Directed by [..] 129,95 € Due January 2008 Fields of interest ISBN 978-3-540-75367-4 Cell Biology; Hematology; Molecular Medicine 2007. Approx. 545 p. 200 illus. Hardcover Target groups 69,95 € Stem cell scientists, laboratory-based researchers, cell ISBN 978-0-387-95033-4 biologists

Type of publication Contributed volume

Due February 2008

2008. Approx. 360 p. 39 illus. 4 in color (Methods in Molecular Biology, Vol. 430) Hardcover

79,95 € ISBN 978-1-58829-868-3 20 Life Science springer.com/booksellers

A. Burger, Western General Hospital, Edinburgh, UK; D. Davidson, R. Burns, Scottish Agricultural Science Agency, Edinburgh, UK M. Camps, P. Chauhan (Eds.) Western General Hospital, Edinburgh, UK; R. Baldock, Western (Ed.) General Hospital, Edinburgh, UK (Eds.) Sourcebook of Paleolithic Plant Pathology Anatomy Ontologies for Transitions Techniques and Protocols Bioinformatics Methods, Theories, and Interpretations

Principles and Practice

Fields of interest The Paleolithic period (2,000,000 years ago to 11,000 Plant Sciences years ago) has a rather varied archaeologi- This book provides a timely and first-of-its-kind col- cal record - partially owing to the transitional pro- lection of papers on anatomy ontologies. It is inter- Type of publication cesses that took place within its subdivisions (Low- disciplinary in its approach, bringing together the Contributed volume er Paleolithic: 2,000,000 years ago to 120,000 year relevant expertise from computing and biomedical ago; Middle Paleolithic: 300,000 years ago to 30,000 studies, and covers both theoretical and applied as- Due January 2009 years ago; and Upper Paleolithic: 40,000 year ago to pects with the emphasis being on newer work rele- 11,000 year ago). These transitional times are vant to the emerging Semantic Web. The book aims not "set in stone" since new archaeological evidence to provide readers with a comprehensive under- 2008. 400 p. (Methods in Molecular Biology, Preliminary entry can move these transition dates significantly. standing of the foundations of anatomical ontologies 2121) Hardcover Because of this, the changes that characterize the and the-state-of-the-art in terms of existing tools and end of one phase and the beginning of another applications. It also highlights challenges that remain 74,95 € ISBN 978-1-58829-799-0 merits a closer examination and treatment. today and which have to be considered when deal- This sourcebook addresses the differing with anatomy-based information on the Seman- ent transitional processes by examinating tic Web. Primarily aimed at readers who will be in- the nature and extent of behavioural changes, cul- volved in developing the Semantic Web or Semantic tural patterns and differences that have been at- Web applications in the areas of Life Sciences, Bio- tributed to them. It brings together a global body of Medical Sciences and /or Health Care, this book will research and compares differing theoretical be relevant to those who will further develop anato- perspectives on the transitions - not only to compare my ontologies, those who will use them, and those [..] involved in the actual development of relevant [..] Features Features brings together an international group of leading re- A timely and first-of-its-kind tightly-edited collec- searchers to discuss past, present and future research tion of papers on anatomy ontologies Highlights the on the Paleolithic transitions approaches the topic challenges that remain today and which will have from a anthropological and theoretical perspective to be considered when dealing with anatomy-based the cases are from around the world, making this a information on the Semantic Web Provide readers truly international sourcbook with a comprehensive understanding of the foundations of anatomical ontologies and the state of the art Contents in terms of existing tools and applications Contributors Acknowledgements Preface Foreword Introduction PART I: METHODOLOGICAL & Contents THEORETICAL PERSPECTIVES Lycett, Stephen: Part 1: Anatomical Ontologies for Model Organ- Quantifying transitions: morphometric approaches isms.- Plant Structure Ontology (PSO).- Anatomy to Palaeolithic variability and technological change for Clinical Terminology.- The Foundational Mod- Blackwell, Bonnie: ESR dating at hominid and ar- el of Anatomy Ontology.- Towards a Disease Ontol- chaeological sites during the Plio-Pleistocene Bar- ogy.- Part II: Engineering and Linking of anatomy Yosef, Ofer: Revolutions and Transitions in Prehis- Ontologies.- Ontology alignment and Merging.- CO- tory Soffer, Olga: The Politics of Rubicons And The BrA and COBrA-CT.- Searching Biomedical Litera- Imagined Pasts Straus, Lawrence: Has the notion ture with Anatomy Ontologies.- Part III: Anatomy of "transitions" in Paleolithic prehistory outlived its Ontologies and Spatio-Temporal Atlases.- Anatomi- usefulness? Gowlett, John: The long gradient of [..] cal Ontologies.- Time in anatomy.- The Edinburgh Mouse Atlas.- The Smart Atlas.- Part IV: Anatomy Fields of interest Ontologies: Modelling Principles.- Modeling Princi- Archaeology; Anthropology ples and [..] Target groups Fields of interest This sourcebook is for archaeologists and anthropol- Computational Biology/Bioinformatics; Bioin- ogists (physical, social, cultural)interested in the Pa- formatics; Information Systems Applications leolithic period and the human transitions between (incl.Internet); Models and Principles; Database its subdivisions. Management; Information Storage and Retrieval Type of publication Target groups Handbook Researchers, developers, graduates Due May 2008 Type of publication Contributed volume 2008. Approx. 810 p. Hardcover Due December 2007 146,30 € ISBN 978-0-387-76478-8 2008. Approx. 350 p. (Computational Biology, Vol. 6) Hardcover

89,95 € ISBN 978-1-84628-884-5 springer.com/booksellers Life Science 21

M.P. Cancro, University of Pennsylvania School of Medicine, J.L. Capinera, University of Florida, Gainesville, FL, USA (Ed.) J.L. Capinera, University of Florida, Gainesville, FL, USA (Ed.) Philadelphia, PA, USA (Ed.) Encyclopedia of Entomology Encyclopedia of Entomology BLyS Ligands and Receptors

This publication brings together fundamental infor- This publication brings together fundamental information on insect taxa, morphology, ecology, behav- mation on insect taxa, morphology, ecology, behav- Contents ior, physiology, and genetics. The close relatives of ior, physiology, and genetics. The close relatives of The BLyS/BLyS receptor family. A natural history insects, such as spiders and mites, are included. Al- insects, such as spiders and mites, are included. Al- of the BLyS/BLyS receptor family of ligands and reso included is information on the role of insects and so included is information on the role of insects and ceptors.- The increasing complexity of BLyS family human culture, insects as pests including the trans- human culture, insects as pests including the trans- ligands.- Structural basis for BLyS family in- mission of diseases to plants and animals, toxicants mission of diseases to plants and animals, toxicants teractions.- Role of BLyS in the primary B cell used for insect control, and other approaches to pests used for insect control, and other approaches to pests pool formation and selection. BLyS and the primary management. The contributions of notable and pi- management. The contributions of notable and pi- B cell: balancing the homeostatic equation.- The role oneering entomologists from around the world are oneering entomologists from around the world are of B AFF in determining thresholds for tolerance and noted. noted. selection.- BLyS and the maturation of B cell subsets.- BLyS family members in the etiology and ther- Features Features apy of humoral autoimmunity. BAFF and APRIL.- This second edition provides a more complete cover- This second edition provides a more complete cover- APRIL – an emerging role in [..] age Addition of index age Addition of index

Fields of interest Contents Contents Immunology; Microbiology No ToC available. No ToC available.

Target groups Fields of interest Fields of interest Immunologists, molecular biologists, cell biologists Invertebrates; Animal Systematics/Taxonomy/Bio- Invertebrates; Animal Systematics/Taxonomy/Bio- geography; Evolutionary Biology; Plant Sciences; geography; Evolutionary Biology; Plant Sciences; Type of publication Ecology Ecology Contributed volume Type of publication Type of publication Due October 2008 Encyclop(a)edia Encyclop(a)edia

2008. Approx. 400 p. (Contemporary Immunology) Hardcover Due July 2008 Due June 2008

123,20 € 2008. eReference. (in 4 volumes, not available separately). 2008. Approx. 4000 p. 1300 illus. (in 4 volumes, not available sep- ISBN 978-1-60327-012-0 arately) Hardcover 525,00 € ISBN 978-1-4020-6359-6 525,00 € ISBN 978-1-4020-6242-1 springer.com/booksellers Life Science 22

M.J. Carena, North Dakota State University, Fargo, ND, USA (Ed.) M.M. Carreiro, University of Louisville, Louisville, KY, USA; Y.-C. D. Carroll, Florida Institute of Technology (Ed.) Song, East China Normal University, Shanghai, China; J. Wu, Ari- zona State University, Tempe, AZ, USA (Eds.) Cereals Microinjection

Ecology, Planning, and Methods and Applications Management of Urban Forests Agriculture depends on improved cultivars, and cultivars are developed through proper plant breeding. An International Perspective Unfortunately, applied plant breeding programs that Fields of interest are focused on cereal commodity crops are under se- Biotechnology rious erosion because of lack of funding. This loss It has been increasingly recognized that trees and of public support affects breeding continuity, ob- Type of publication vegetation in urban areas provide a number of eco- jectivity, and, perhaps equally important, the train- Contributed volume ing of future plant breeders and the utilization and logical services beyond beautifying cities. The pur- improvement of plant genetic resources currently pose of urban forestry is to use trees and natural Due January 2009 available. Breeding programs should focus not only habitat patches to ameliorate negative environmental on short-term research goals but also on long-term impacts of cities and to contribute to the creation of genetic improvement of germplasm. The research more livable, ecological sustainable “co-cities”. Ecol- 2008. 300 p. (Methods in Molecular Biology, Preliminary entry products of breeding programs are important not ogy, Planning, and Management of Urban Forests 2094) Hardcover only for food security but also for commodity-ori- takes an international approach to sharing knowl- 74,95 € ented public and private programs, especially in the edge about the management of urban forests that ISBN 978-1-58829-884-3 fringes of crop production. Breeding strategies used has been learned through studies in many different for long-term selection are often neglected but the regions. This allows the reader to evaluate methods reality is that long-term research is needed for the and management that are appropriate for particular success of short-term products. An excellent example geographic, environmental and socio-political con- is that genetically broad-based public [..] texts. Urban forests are also approached on regional and landscape scales to encompass more natural en- Features vironments in and around cities, rather than within present all of the major cereal crops from maize to arbitrary municipal boundaries. sorghum to rice include discussions of the genetic diversity, breeding methods and techniques, integra- Features tion of new biotechnologies and seed production in Takes an international approach to sharing knowl- each chapter great interest to students and scientists edge about the management of urban forests Allows alike a unique, new, and exciting contribution to the the reader to evaluate methods and management field of cereal breeding that are appropriate for particular geographic, environmental and socio-political contexts Combines Contents knowledge gathered from case studies in many dif- Maize.- Rice.- Wheat.- Durum Wheat.- Sorghum.- ferent regions Barley.- Oat.- Rye.- Triticale.- Pearl Millet.- Index. Contents Fields of interest Preface.- Part One: Perspectives and Approaches in Plant Genetics & Genomics; Plant Sciences; Agricul- Urban Forestry: Introduction: The Growth of Cities ture and Urban Forestry.- Towards a Landscape Ecol- ogy of Cities: Beyond Buildings, Trees, and Urban Target groups Forests.- Principles for Guiding Eco-City Develop- plant breeders, researchers and as a suggested book ment.- A Multiple-Indicators Approach for Monitor- in plant breeding courses. ing Urban Sustainable Development.- Assessment and Valuation of the Ecosystem Services Provided Type of publication by Urban Forests.- Benefits of Urban Green Space Contributed volume for Improving Urban Climate.- Applying Ecosystem Management to Urban Forestry.- Approaches to Ur- Due November 2007 ban Forestry in the United Kingdom.- Opportunities and [..]

2007. Approx. 350 p. (Handbook of Plant Breeding, Vol. 3) Hard- Fields of interest cover Ecology; Applied Ecology; Forestry Management; 99,35 € Environmental Management; Ecosystems ISBN 978-0-387-72294-8 Target groups Researchers, students, managers and planners in urban ecology and urban forestry

Type of publication Contributed volume

Due December 2007

2008. Approx. 250 p. (Springer Series on Environmental Manage- ment) Hardcover

62,95 € ISBN 978-0-387-71424-0 springer.com/booksellers Life Science 23

O. Carugo, Vienna University, Vienna, Austria; F. Eisenhaber, Re- F.S. Chapin, III, University of Alaska, Fairbanks, AK, USA; G. Kofi- search Institute of Molecular Pathology, Vienna, Austria (Eds.) nas, University of Alaska, Fairbanks, AK, USA; C. Folke, University 2009. Approx. 400 p. Hardcover of Stockholm, Stockholm, Sweden (Eds.) 38,50 € Data Mining Techniques for the Life ISBN 978-0-387-73032-5 Sciences Principles of Natural Resource Stewardship

Resilience-Based Management in a Changing World

Fields of interest Bioinformatics; Computer Appl. in Life Sciences; Biotechnology This is a textbook for Natural Resource Manage- ment, Resource Conservation and Ecosystem Man- Type of publication agement, as well as other related or more special- Monograph ized courses. Most textbooks on natural resource and ecosystem management are dominated by a steady- state view that interprets change as gradual and in- Due December 2008 cremental and disregards interactions across scales. Management implementation of steady-state theory 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary and policies tends to invest in controlling a few se- entry 2237) Hardcover lected ecosystem processes, at the expense of long- term social-ecological resilience—i.e., the capacity of 76,65 € the system to cope with surprise and abrupt changes. ISBN 978-1-60327-240-7 Loss of resilience makes systems more vulnerable to both expected and unforeseen changes. Achieving desirable outcomes for humanity, such as those of the UN Millennium Development Goals on poverty, food security, and environmental sustainability, will require new integrated and adaptive approaches to social and economic development, where the complex interconnectedness between humans and nature, at all [..]

Features 1. Textbook for Natural Resource Management and related courses. 2. First textbook to take a resilience-based approach to the ecology and management of resources. It focuses on ecosystems ability to adapt to change. 3. Chapin is the author of Principles of Torrestrial Ecosystem Ecology & Plant Phys- iological Ecology. 4. Provides a framework for managing resources in a world dominated by uncertainty and [..]

Contents A Framework for Understanding Change.- Manag- ing Ecosystems Sustainably.- Human vulnerability, adaptation, and resilience.- Dynamics of integrated social-ecological systems.- Conservation and livelihoods: Sustaining and restoring the cultural connections to land.- Landscape stewardship: Discovering the missing connections to sustain vulnerable systems.- Forest systems: Living with long-term change.- Drylands: Coping with uncertainty, thresholds, and changes in state.- Lakes and rivers: Managing connections across temporal and spatial scales.- Oceans and [..]

Fields of interest Environmental Management; Nature Conservation; Monitoring/Environmental Analysis/Environmen- tal Ecotoxicology; Ecosystems; Environmental Law; Geoecology/Natural Processes

Target groups Nat Resources, Conservation, Ecosystem management undergrad and grad stdnts, mangers and policy makers with ecology, anthropology, economics, and political science backgrounds.

Type of publication Graduate/advanced undergraduate textbook

Due April 2009 24 Life Science springer.com/booksellers

S.P. Chellappan (Ed.) Y. Choi, University of Pennsylvania, Philadelphia, PA, USA (Ed.) A. Ciancio, C.N.R., Bari, Italy; K.G. Mukerji, University of Delhi, In- dia (Eds.) Chromatin Protocols Osteoimmunology Integrated Management and Interactions of the Immune and Skeletal Systems Biocontrol of Vegetable and Grain Crops Nematodes Fields of interest Cell Biology A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF- Type of publication KB Ligand.- The Negative Role Of Ids In Osteoclas- The second volume of the IMPD series describes as- Contributed volume togenesis.- Functional Genetic and Genomic Analy- pects related to most important phytoparasitic nesis of Modeled Arthritis.- Dexamethsone Suppress- matodes, considering the integration of biological Due January 2009 es Bone Formation via the Osteoclast.- Immuno- control methods with other management practices logic Regulation Of Bone Development.- Pth Regu- and technologies, including the use of predatory lates The Hematopoietic Stem Cell Niche In Bone.- nematodes and microbial rhizosphere antogonists. 2008. Approx. 300 p. (Methods in Molecular Biology, Preliminary Regulation Of Hematopoietic Stem Cells In The Os- Chapters cover topics like the mode of action and in- entry 2015) Hardcover teoblastic Niche.- The Chemokine Cxcl12 And Regu- teractions of nematophagous fungi, the efficacy of 74,95 € lation Of Hsc And Lymphocyte Development In The control and management of plant parasitic nematode ISBN 978-1-58829-873-7 Bone Marrow Niche.- Osteoclast Precursor Cells.- communities through a soil conservation approach, Interaction with estrogen receptors as treatment of and exploitation of nematodes-bacteria antagonis- arthritis and osteoporosis.- Novel Signaling Path- tic relationships. A focus is given on regional issues, ways And Therapeutic Targets In Osteoclasts.- The like the management of nematodes parasitizing sta- Enigmatic Function of TREM-2 in Osteoclastogen- ple crops, i.e. andean tubers or some important grain esis.- Role of cell-matrix interactions in osteoclast crops, like soybean in North and South America or differentiation.- Positive and negative roles of IL-6, cereals. A review on nematode management in cot- STAT3 and SOCS3 in inflammatory arthritis.- Con- ton is integrated by a chapter on management of trol of Osteoclast activity and bone loss by IKK sub- nematodes on wheat. New technologies are also re- units: new targets for [..] vised, including the potentials of control methods based on RNA interference and issues related to the Features use of [..] Proceedings from the 1st International Conference on Osteoimmunology: Interactions of the Immune Contents and Skeletal Systems Introduction. 1. General review on integrated management of nematodes of cotton, including genetics Fields of interest and resistance. 2. IPM of soybean nematodes in the Immunology; Microbiology; Infectious Diseases; USA. 3. Biological and integrated control of root- Biotechnology; Pathology; Pharmacology/Toxicology knot nematodes by parasitic fungi. 4. Management of root and tuber crops nematodes in Andean crop- Target groups ping systems. 5. Integrated management of root-knot Immunologists, microbiologists, infectious disease nematodes in Mediterranean horticultural systems. specialists, clinicians, physicians, pharmacologists, 6. Integrated management of soybean nematodes in pharmaceutical researchers, pathologists, biotechnol- Latin America. 7. Management of cyst nematodes ogists with natural products. 8. Biofumigation of plant par- Type of publication asitic nematodes. 9. Plant parasitic nematode [..] Proceedings Fields of interest Plant Sciences; Plant Pathology; Invertebrates; Agri- Due November 2007 culture; Ecology

2008. XVI, 156 p. 33 illus., 2 in color. (Advances in Experimental Type of publication Medicine and Biology, Vol. 602) Hardcover Contributed volume

124,95 € Due October 2007 ISBN 978-0-387-72008-1

2007. Approx. 360 p. (Integrated Management of Plant Pests and Diseases, Vol. 2) Hardcover

150,00 € ISBN 978-1-4020-6062-5 springer.com/booksellers Life Science 25

R. Cihlar, Georgetown University Medical Center; R. Calderone J. Cino, New Brunswick Scientific Co., Inc. Edison, NJ, USA (Ed.) J.B. Cliff, Pacific Northwest National Laboratory, Richland, WA, (Eds.) USA (Ed.) Fermentation Methods Candida Albicans Chemical and Physical Signatures for Microbial Forensics

Fields of interest Fields of interest Applied Microbiology Microbiology Fields of interest Type of publication Bacteriology; Microbiology; Virology Type of publication Contributed volume Contributed volume Type of publication Due August 2008 Contributed volume Due October 2008

2008. (Methods in Biotechnology, Preliminary entry 1000) Hard- Due February 2009 2008. (Methods in Molecular Medicine, Preliminary entry 2006) cover Hardcover 104,95 € 2009. Approx. 350 p. (Infectious Disease) Hardcover 99,95 € ISBN 978-1-58829-135-6 92,40 € ISBN 978-1-58829-760-0 ISBN 978-1-60327-217-9 26 Life Science springer.com/booksellers

C. Clini, Italian Ministry for the Environment, Land and Sea, M. Clokie, University of Warwick, Coventry, UK; A.M. Kropinski L. Cocolin, University of Turin, Grugliasco, Italy; D. Ercolini, Uni- Rome, Italy; I. Musu, Venice International University, Italy; M.L. (Eds.) versity of Naples Federico II, Portici, Italy (Eds.) Gullino, Agroinnova - University of Turin, Italy (Eds.) Bacteriophages Molecular Techniques in the Sustainable Development and Methods and Protocols Microbial Ecology of Fermented Environmental Management Foods Experiences and Case Studies

Fields of interest With the application of new analytical techniques, Microbiology This book presents the new EU approach to envi- the field of food fermentation has grown over last ronmental management and its attempt to place it Type of publication few years. Because of this, the approach to study in the perspective of sustainable development. Chi- Contributed volume bacteria in food has changed. Consequently new in- na and other large and fast growing economies are formation is available on the structure and dynam- putting increasing pressures on global environment, ics of microbial populations during fermented food but they are also looking at the European experience Due August 2008 production. Molecular Techniques in the Microbial with great interest. To critically present this expe- Ecology of Fermented Foods provides the latest in- rience can help those countries avoid the mistakes 2008. Approx. 350 p. (Methods in Molecular Biology, Preliminary formation and relevant advances on the microbial made by developed countries in dealing with the re- entry 2007) Hardcover ecology of fermented foods and the application of lation between economic growth and environmen- molecular methods. This book serves as a guide for tal protection, and to improve the institutions and 74,95 € students and researchers on the most advanced tech- tools for better environmental governance. The va- ISBN 978-1-58829-682-5 niques to identify bacteria and helps in choosing the riety of issues covered and the wide approach used most appropriate tools to study fermented food from in this book make it a useful tool for readers a microbiological point of view. who want to place themselves in this perspective, although starting from different backgrounds and lev- Features els of knowledge on environmental and sustainabili- presents insights into microbial ecology of fermented ty sciences. foods discuss the applications of molecular methods in relation to studying fermentation Fields of interest Urbanism; Environmental Management; Economic Contents Growth; Economic Policy; R & D/Technology Policy; Preface.- Molecular techniques in food fermentation: Environmental Economics principles and applications.- Dairy products.- Fer- mented meat products.- Sourdough fermentations.- Type of publication Vegetable fermentations.- Wine Fermentation.- Contributed volume Beer production.- Other fermentations.- Probiotics: lessons learned from nucleic acid-based analysis of Due October 2007 bowel.- Bioinformatics for DNA sequence-based mi- crobiota analyses.- Role of bacterial "omics" in food fermentation.- Index. 2007. Hardcover Fields of interest 120,00 € Food Science; Biotechnology; Microbiology ISBN 978-1-4020-6597-2 Target groups Students, researchers, and scientists in the fields of food microbiology, food fermentation and fermented food production, and food safety

Type of publication Contributed volume

Due December 2007

2008. Approx. 305 p. (Food Microbiology and Food Safety) Hard- cover

107,05 € ISBN 978-0-387-74519-0 springer.com/booksellers Life Science 27

P. Collas, University of Oslo, Norway (Ed.) L.M. Coluccio, Boston Biomedical Research Institute, Watertown, M. Cretich, ICRM, Milano, Italy; M. Chiari, ICRM, Milano, Italy (Eds.) MA, USA (Ed.) Chromatin Immunoprecipitation Peptide Microarrays Assays Myosins A Superfamily of Molecular Motors Peptide Microarrays: Methods and Protocols is a view on the peptide array technology, on its appli- The goal of this volume is to introduce the ChIP as- cations and technical issues. The volume offers to say in an historic context, then develop a series of This volume highlights the remarkable superfami- chemists, biologists and biochemists the basis to ap- ChIP protocols, extend these protocols to related ap- ly of molecular motors called myosins, which are in- preciate the potential of this technique and a deep in- proaches such as DamID or MedIP – methods which volved in such diverse cellular functions as muscle sight into protocols. Innovative methodologists de- regardless do concern all those doing ChIP assays contraction, intracellular transport, cell migration scribe in details how to realize and exploit an effec- – and include a section on analysis of complex data and cell division. In a timely compilation of chapters tive peptide array using new substrates, immobiliza- sets generated by genome-wide ChIP assays. written by some of the leading research groups in the tion chemistries and detection technologies. Experts world that have made key discoveries in the field, the present a broad range of applications such as epitope Fields of interest current understanding of the molecular mechanisms mapping, diagnostics, enzyme characterization. In- Biochemistry, general; Molecular Medicine; Cell Bi- and biological functions of these intriguing proteins formation obtained from peptide arrays are likely ology is explored.The different myosin classes are com- to open advanced opportunities for functional pro- pared and contrasted in the introductory chapter, as tein analysis and for the design of substrates and in- Target groups well as chapters on myosin structure; and biochem- hibitors useful in diagnostics and drug discovery. Biochemists, molecular biologists, cell biologists, and ical and kinetic properties of myosins. Subsequent stem cell biologists chapters are devoted to single classes of myosins and Fields of interest provide keen insight based on studies using in vitro Type of publication Cell Biology; Proteomics; Pharmacology/Toxicology; and in vivo systems into how particular myosins are Contributed volume Biochemistry, general designed for their intracellular roles. This highly authoritative and comprehensive volume includes cur- Target groups Due September 2009 rent information on myosin mutations, which are re- Chemists, biologists, biochemists, and pharmacolo- sponsible for diseases such [..] gists 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary entry 2255) Hardcover Features Type of publication chapters are written by experts in the field volume Contributed volume 76,65 € represents a compilation of information regarding ISBN 978-1-60327-413-5 many different myosins comprehensive nature of Due September 2009 chapters with introductory chapters that deal with all myosin classes and other chapters that focus on one class timely and up-to-date fully referenced; more- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary over, index allows easy use as reference book entry 2262) Hardcover

Contents 76,65 € List of contributors.- Structural and functional di- ISBN 978-1-60327-393-0 versity of the myosin family of actin-based molecular motors.- Myosin structure .- The myosin family: biochemical and kinetic properties.- Myosin I.- Myosin II: Sarcomeric myosins, the motors of contraction in cardiac and skeletal muscles.- Smooth- muscle myosin II.- Non-muscle myosin II.- Class III Myosins.- Myosin V.- Myosin VI: a multifunction- al motor protein.- Myosin VII.- Plant Myosins VIII, XI, and XIII.- Class IX Myosins Negative Regulators of the small GTP-binding Protein Rho.- Myosin X.- Myosin XIV and other myosins in protists.- [..]

Fields of interest Cell Biology; Biochemistry, general; Biomedicine general

Target groups Medical professionals, those interested in molecular motors.

Type of publication Contributed volume

Due November 2007

2007. Approx. 500 p. (Proteins and Cell Regulation, Vol. 7) Hard- cover

149,95 € ISBN 978-1-4020-6516-3 28 Life Science springer.com/booksellers

J.R. Crowther, International Atomic Energy Agency, Vienna, Aus- H. Czosnek, The Hebrew University of Jerusalem, Rehovot, Israel C. Dahmann, Max Planck Institut of Molecular Cell Biology and tria (Ed.) Genetics, Dresden, Germany (Ed.)

The ELISA Guidebook Tomato Yellow Leaf Curl Virus Drosophila Disease

Management, molecular biology, breeding for resistance John R. Crowther provides today's premier practi- Drosophila is a comprehensive collection of methods cal guide to the understanding and application of and protocols for Drosphila, one of the oldest and ELISA. Updating and greatly expanding his wide- most commonly used model organisms in modern ly appreciated earlier publication, ELISA Theory This book will awaken the interest of breeders, phy- biology. The text presents a diverse set of techniques and Practice (1995), this important work introduces topathologists, environmentalists, extension services, that range from the basic handling of flies to more chapters on such major new topics as checkerboard plant virologists, entomologists and molecular biolo- complex applications, such as the generation of mu- titrations, quality control of testing, kit production gists. It deals both with the epidemiological aspects tants by homologous recombination and the analysis and control, novel monoclonal antibodies, validation of the disease and with integrated pest management of developing flies by live imaging. Review chapters of assays, statistical requirements for data examina- in the field. It discusses the efforts aimed at breeding provide concise overviews of selected experimental tion, and epidemiological considerations. With its tomato plants resistant to the virus (using classical systems. Drosophila is the perfect reference manual numerous worked examples, detailed instructions, breeding, marker-assisted breeding and genetic en- for Drosphila researchers. The straightforward pre- and extensive illustrations, The ELISA Guidebook gineering). It summarizes the techniques used for di- sentation of Drosophila protocols will bolster suc- offers a powerful synthesis of all the basic concepts agnosis, eradication and certification and emphasizes cessful experimental design and lead to reproducible and practical experimental details investigators need the problems inherent to the control of the virus in- results, and the troubleshooting tips are an invalu- to understand, develop, and apply the new ELISA sect vector, the use of pesticides and the resistance able aid for researchers at all levels. Drosophila will methodology successfully in day-to-day basic and acquired by the insects, the appearance of new white- advance the use of Drosophila as a model organism clinical research. fly biotypes with previously unknown characteristics, by collecting standard, introductory protocols and and the complex relations between virus, vector and advanced protocols, simultaneously providing a plat- Contents plant host. form for introductory research and facilitation ad- Overview of ELISA in Relation to other Disciplines. vanced study. Systems in ELISA. Stages in ELISA. Titration of Features Reagents. Theoretical Considerations. Practical Ex- Offers a multidisciplinary view on one of the major Features ercises. Monoclonal Antibodies. Validation of Diag- diseases of tomato crops, the tomato yellow leaf curl Protocols are written by the scientists who invented nostic Tests for Infectious Diseases. Charting Meth- disease Compiles the numerous aspects of the rela- the methods Includes methods for homologous re- ods for Internal Quality Control. Immunochemical tion between the virus, the tomato host plant and the combination in Drosophila Includes methods for live Techniques. Test Questions. whitefly vector Presents papers on classical epidemi- imaging in embryos, larvae, and pupae ology of the viral disease as well as up-to-date molec- Fields of interest ular research Deals with the effort of researchers and Contents Cell Biology companies to breed tomato plants resistant [..] Drosophila melanogaster and the Development of Biology in the XX century.- Getting start- Target groups Fields of interest ed: An overview on raising and using Drosophi- Immunology, Molecular and Cell Biologists, Bio- Plant Pathology; Plant Genetics & Genomics; Plant la.- FlyBase: A database for the Drosophila chemists, Pathologists and Laboratory Medicine Re- Sciences research community.- The use of P-element searchers, Microbiologists, Virologists, Hematolo- transposons to generate transgenic flies.- The gists, and all researchers using biochemical assays Target groups GAL4 system: a versatile system for the expression of Researchers, plant breeders, growers genes.- P-element mutagenesis.- EMS Type of publication Screens: From mutagenesis to screening and map- Contributed volume Type of publication ping.- RNAi screening in cultured Drosophila cells.- Contributed volume Methods for homologous recombination in Due November 2008 Drosophila.- Recombinases and their use in Due October 2007 gene [..] 2009. Approx. 400 p. (Methods in Molecular Biology, Vol. 149) Fields of interest Hardcover 2008. Approx. 455 p. Hardcover Cell Biology; Animal Genetics and Genomics 107,80 € 134,95 € ISBN 978-1-60327-253-7 ISBN 978-1-4020-4768-8 Target groups Geneticists, developmental biologists, molecular and cell biologists, graduate students and post docs

Type of publication Contributed volume

Due November 2007

2008. Approx. 410 p. 88 illus. (Methods in Molecular Biology, Vol. 420) Hardcover

74,95 € ISBN 978-1-58829-817-1 springer.com/booksellers Life Science 29

V. Danilov-Danil'yan, The Central Instititue of Economics and S.S. Daoud, Washington State University, Pullman, WA, USA (Ed.) G. Davis, Sigma-Aldrich, St. Louis, MO, USA; K.J. Kayser, Sig- Mathematiics of the USSR Academy of Science, Russia; K.S. Losev, ma-Aldrich, St. Louis, MO, USA (Eds.) Russian Academy of Sciences, Moscow, Russia; I.E. Reyf, Frankfurt am Main, Germany Cancer Proteomics Chromosomal Mutagenesis From Bench to Bedside Sustainable Development and the Limitation of Growth Great disparities exist between organisms with re- This book provides the reader with broad perspec- Mankind's Greatest Challenge gard to the relative ease of chromosomal mutagene- tives and breadth of knowledge on current topics sis and manipulation. In Chromosomal Mutagenesis, related to the use of proteomic strategies in cancer a team of experts provide a variety of chromosomal therapy as well as anticipated challenges that may manipulation techniques, including insertional gene arise from its application in daily practice. The book disruptions, gene knockouts, stimulated homologous Features is divided into 4 parts. The first part begins with the recombination techniques and other novel tools, for Addresses one of the most urgent and critical prob- current technologies used in proteomics that allow both prokaryotic and eukaryotic organisms, and at- lems of our civilization. Highlights the importance for protein profiling and for the identification of tempt to expand the genetic toolbox beyond model of global environmental stability. Shows humanity druggable targets in human samples. Mass spectrom- organisms. Following the format of the highly suc- its real place in the natural environment. Emphasizes etry based protein characterization and protein mi- cessful Methods in Molecular Biology™ format, each the gravity of the ecological threat before us. Demon- croarrays hold great promise of predicting response chapter offers step-by-step laboratory instructions, strates the need to move from modern industrial to specific drugs in cancer therapy. The second part lists of the necessary equipment and reagents, and thinking to new ecological thinking. Takes a holistic deals with the use proteomics in cell signaling. At the tips on troubleshooting and avoiding known pitfalls. approach to the global economic [..] present, the pharmaceutical and biotechnology in- Comprehensive and cutting-edge, Chomosomal Mu- dustries have many potentially useful small molecule tagenesis covers state-of-the-art techniques that are Fields of interest inhibitors of many pathways important in cancer Environmental Management; Climate Change; Envi- staged to expand, if not revolutionize, genetic analy- that have yet to be taken to clinical trials. Under- sis in the long neglected and relevant cell types. ronment, general; Environmental Economics standing protein-protein interaction and posttranslational modifications through proteomics will likely Target groups Features make it much more feasible to do [..] Undergraduate and postgraduate students and re- Highlights techniques involving a wider variety of searchers of global change, ecology and sustainable cell types and organisms Contains state-of-the-art Features methods in step-by-step laboratory format development Comprehensive look at the use of proteomic strategies in cancer therapy Covers all the latest technolo- Type of publication Contents gies used in proteomics Includes in-depth informa- Monograph Biallelic Gene Knockouts in Chinese Hamster Ovary tion on the human proteome and the role of the FDA Cells.- Highly Proficient Gene Targeting by Ho- in regulating the use of proteomics The latest re- mologous Recombination in the Human pre-B Cell Due May 2008 search on proteomics and tyrosine kinases p53 sig- Line Nalm-6.- Robust Cell Line Development Using nalling and tumor biomarkers Discusses the future Meganucleases.- Design and Testing of Zinc Finger 2008. Approx. 210 p., 30 illus. (Environmental Sciences) Hardcov- uses of proteomics in therapeutic individualization Nucleases for Use in Mammalian Cells.- Gene Tar- er and target [..] geting in Drosophila and C. elegans with Zinc-finger Nucleases.- Orpheus Recombination: A Compre- 79,95 € Contents hensive Bacteriophage System for Murine Targeting ISBN 978-3-540-75249-3 Current and emerging mass spectrometry instru- Vector Construction by Transplacement.- Transpo- mentation and methods for proteomic analyses.- son Mediated Mutagenesis in Somatic Cells: Identi- Integration of genomics and proteomics in dissect- fication of transposon-genomic DNA junctions.- In- ing p53 signaling.- Proteomic profiling of tyrosine sertional [..] kinases as pharmacological endpoints for targeted cancer therapy.- Oncoproteomics for personalized Fields of interest management of cancer.- Application of serum and Human Genetics; Cell Biology; Molecular Medicine tissue proteomics to understand and detect solid tumors.- Insight on renal cell carcinoma proteome.- Target groups Proteomics in lung cancer.- Proteomic strategies of Geneticists, molecular and cellular biologists therapeutic individualization and target discovery in acute myeloid leukemia.- New tumor biomarkers: [..] Type of publication Contributed volume Fields of interest Cancer Research; Proteomics; Oncology Due March 2008 Target groups Cancer researchers, oncologists, cancer clinicians, 2008. Approx. 395 p 36 illus. 3 in color (Methods in Molecular Bi- bioinformaticists ology, Vol. 435) Hardcover 79,95 € Type of publication ISBN 978-1-58829-899-7 Contributed volume

Due January 2008

2008. Approx. 279 p. 16 illus. (Cancer Drug Discovery and Devel- opment) Hardcover

96,95 € ISBN 978-1-58829-858-4 30 Life Science springer.com/booksellers

G. De Libero, University Hospital Basel, Basel, Switzerland (Ed.) F. DeLeo, NIH, Hamilton, MT, USA; M. Otto, NIH, Hamilton, MT, A. Demirbas, Sila Science and Energy, Trabzon, Turkey USA (Eds.) T Cell Protocols Biodiesel Bacterial Pathogenesis A Realistic Fuel Alternative for Diesel Engines Methods and Protocols

Fields of interest Biochemistry, general Environmental and political concerns are generat- Bacterial infections affect world health today as a ing a growing interest in alternative engine fuels such Type of publication leading cause of morbidity and mortality. Pathogenic as biodiesel. Biodiesel is a renewable energy source Contributed volume bacteria routinely command a broad spectrum of produced from natural oils and fats, which can be niches in the human host, making an understand- used as a substitute for petroleum diesel without the ing of pathogenesis mechanisms crucial to the devel- Due August 2008 need for diesel engine modification. In addition to opment of prophylactics and treatment for bacteri- being biodegradable and non-toxic, biodiesel is also al diseases. A variety of in vitro methods, in vivo an- essentially free of sulfur and aromatics, producing 2008. (Methods in Molecular Biology, Preliminary entry 2150) imal model systems and cutting-edge genomics as- lower exhaust emissions than conventional gasoline Hardcover says have arisen in the effort to study bacterial patho- whilst providing similar properties in terms of fuel genesis and identify potential therapeutic targets. In 99,95 € efficiency. The greatest drawback of using pure veg- Bacterial Pathogenesis, in-depth methods and state- ISBN 978-1-58829-587-3 etable oils as fuels are their high viscosity, although of-the-art protocols are presented for investigating this can be reduced by techniques such as dilution, specific mechanisms of pathogenesis for a wide range micro-emulsification, pyrolysis or transesterification. of bacteria. This invaluable collection includes pro- Of these processes, the transesterification of veg- tocols to study host-pathogen interactions, animal etable oil triglycerides in supercritical methanol has models of infection, and novel approaches to iden- been shown to be particularly promising, producing tifying therapeutic targets designed to control in- high yields of low-viscosity methyl esters without the fections. Up-to-date molecular typing methods for need of a catalyst. Furthermore, these methyl esters Staphylococcus aureus and a new model of strepto- have a [..] coccal pharyngitis in non-human primates are [..] Features Features Describes the production and characterisation of Collects time-tested, reproducible laboratory proto- biodiesel, along with current experimental research cols, including tricks and hints, written by experts in work in the field the field Investigates specific mechanisms of pathogenesis for a wide range of bacteria Includes novel Contents approaches for identifying therapeutic targets de- Introduction to Energy Sources.- Biofuels.- Veg- signed to control infections etable Oils and Animal Fats.- Biodiesel.- Biodiesel from Triglycerides via Transesterification.- Fuel Contents Properties of Biodiesels.- Current Technologies in Isolation and Characterization of Lipopolysaccha- Biodiesel Production.- Engine Performance Tests.- rides.- Proteomic Analysis of Proteins Secreted by Global Renewable Energy and Biofuel Scenarios.- Streptococcus pyogenes.- Proteomic Analysis to In- Biodiesel Economy and Biodiesel Policy. vestigate Regulatory Networks in Staphylococcus aureus.- Microarray Comparative Genomic Hybridiza- Fields of interest tion for the Analysis of Bacterial Population Genet- Biochemical Engineering; Renewable Energy ics and Evolution.- Detection and Inhibition of Bac- Sources; Environmental Biotechnology terial Cell-Cell Communication.- A System for Site- Specific Genetic Manipulation of the Relapsing Fever Target groups Spirochete Borrelia hermsii.- Transposon Mutagene- Advanced undergraduates, postgraduates and resis of the Lyme Disease Agent Borrelia burgdorferi.- searchers in renewable energy; fuel engineers The Biofilm Exopolysaccharide [..] Type of publication Fields of interest Monograph Microbiology; Immunology; Cell Biology Due February 2008 Target groups Microbiologists, immunologists, cell biologists, infectious disease clinicians, pathogenic bacteria re- 2008. Approx. 245 p. Hardcover searchers 84,95 € ISBN 978-1-84628-994-1 Type of publication Contributed volume

Due March 2008

2008. Approx. 414 p. 37 illus. 10 in color (Methods in Molecular Biology, Vol. 431) Hardcover

79,95 € ISBN 978-1-58829-740-2 springer.com/booksellers Life Science 31

W.C. Dennison, University of Maryland, Center for Environmen- V. Deretic, University of New Mexico Health Sciences Center, Al- A. Desbonnet, University of Rhode Island, Narragansett, RI, USA; tal Science, Cambridge, MD, USA; W.M. Kemp, University of Mary- buquerque, NM, USA (Ed.) B.A. Costa-Pierce, University of Rhode Island, Narragansett, RI, land, Center for Environmental Science, Cambridge, MD, USA; USA (Eds.) V.S. Kennedy, University of Maryland, Center for Environmen- tal Science, Cambridge, MD, USA; J.E. Petersen, Oberlin College, Autophagosome and Phagosome Lewis Center for Environmental Studies, Oberlin, OH, USA (Eds.) Science of Ecosystem-Based Management Enclosed Experimental Ecosystems Autophagy and phagocytosis are distinct yet par- Narragansett Bay in the 21st Century and Scale tially morphologically similar processes. In Au- tophagosome and Phagosome, authoritative scien- Tools for Understanding and Managing Coastal Ecosystems tists present easy-to-follow methods on autophagy, a rapidly growing field with a need for standards of as- Science for Ecosystem-Based Management: Narra- sessment, and phagocytosis, a relatively mature field gansett Bay in the 21st Century addresses the broad which could benefit greatly from updated methods, problem of coastal nutrient pollution. In the U.S., Enclosed ecosystem experiments have gained in pop- in order to prompt further explorations of their sim- approximately two-thirds of the coastal rivers and ularity as research tools in ecological science, partic- ilarities and differences. The methods on autophagy bays are moderately to severely degraded from nu- ularly in the study of coastal aquatic environments. allow the reader to find appropriate techniques to trient pollution. However, debates continue about These systems provide scientists with a degree of ex- identify, monitor, and quantify autophagic processes, how large a problem nutrient pollution is and what perimental control that is not achievable through while the methods devoted to phagocytosis provide actions to take, and since effective management re- field experiments. Yet to date, techniques for sys- researchers with several modern techniques quires decisions at a local scale, an in-depth case tematically extrapolating results from small-scale ex- for in vitro and in vivo studies of phagosomal or- study can provide valuable guidance. Narragansett perimental ecosystems to larger, deeper, more open, ganelles. Comprehensive and forward-thinking, Au- Bay is one of the best-studied estuaries in the world. more biologically diverse, and more heterogeneous tophagosome and Phagosome offers a valuable guide Rhode Island has been developing regulatory and ecosystems in nature have not been well developed. to both cellular processes while inciting researchers management actions to reduce nutrient inputs, par- Likewise, researchers have lacked methods for com- to explore the potentially important connections be- ticularly those of nitrogen, to the waters of Narra- paring and extrapolating information among natu- tween the two. gansett Bay. This book was developed in response to ral ecosystems that differ in scale. Enclosed Experi- a symposium addressing this mandate with coastal/ mental Ecosystems and Scale: Tools for Understand- Features estuarine scientists and environmental management ing and Managing Coastal Ecosystems provides sci- Autophagosome and phagosome methods agency personnel. The contributors use long-term entists, managers, and policy makers with an intro- for novices and advanced researchers alike data sets to discuss the interactions among biologi- duction to what has been termed the "problem of Vital for the studies of cancer, aging, neurode- cal, ecological, chemical, and physical processes, and scale", and presents information that will allow for generation, immunology, and infectious diseases [..] improved design and interpretation of enclosed ex- Contains molecular, genetic, biochemical, imaging, perimental aquatic ecosystems. The book integrates cellular, animal, and ultrastructural analyses Au- Features [..] tophagy essentials for researchers working on apop- Large case study provides detailed information on tosis and cell death who want to add autophagy to nutrient pollution for students, researchers and pro- Features their studies fessionals Local approach provides managers with Stand-alone pages are designed for quick and easy useful guidance and solutions Interactions between reference Color illustrations throughout A unique Contents biological, ecological, chemical and physical process- reference for those who work with experimental Fine Structure of the Autophagosome.- Methods for es in Narragansett Bay are explored ecosystems Assessing Autophagy and Autophagic Cell Death.- LC3 and Autophagy.- Amino Acid Regulation of Au- Contents Contents tophagosome Formation.- Autophagic Proteolysis of Preface.- 1. Geologic and contemporary landscapes Preface.- Introduction and Background: Coastal Long-lived Proteins in Non-liver Cells.- Autophago- of the Narragansett Bay ecosystem.- 2. Narragansett ecosystems, management, and research.- Concepts somes in Transgenic Mice.- Experimental Control Bay amidst a globally changing climate.- 3. Estimat- of scale in ecology.- Mesocosms and scaling pat- and Characterization of Autophagy in Drosophi- ing atmospheric nitrogen deposition in the North- terns.- Using mesocosms to study the effects of la.- Analysis of Autophagosome Membrane Cycling eastern United States: Relevance to Narragansett scale.- Designing Experimental Ecosystem Stud- by Fluorescence Microscopy.- Protein Trafficking Bay.- 4. Groundwater nutrient transport and input ies: General principles.- Temporal and spa- into Autophagosomes.- Sphingolipids in Macroau- along the Narragansett Bay coastal margin.- 5. Ni- tial scaling.- Mixing and flow.- Materials exchange.- tophagy.- Clearance of Mutant Aggregate-prone Pro- trogen and phosphorus inputs to Narragansett Bay: Light.- Walls.- Temperature.- Physical and biological teins by Autophagy.- Localization and MHC Class II past, present and future.- 6. Nitrogen inputs to Nar- complexity.- Aquatic grasses.- Marshes.- Sediments.- Presentation [..] ragansett Bay: An Historical Perspective.- 7. Anthro- Chemistry.- Tools for Design and Analysis of Experi- pogenic eutrophication of Narragansett Bay: evi- ments: The world is variable.- Dimensional analysis.- Fields of interest dence from dated sediment cores.- 8. [..] Modeling tools.- Applications: Benthic [..] Cell Biology; Biochemistry, general; Molecular Medicine; Microbiology Fields of interest Fields of interest Marine Ecology; Environmental Management; Theoretical Ecology; Marine Ecology; Ecosystems; Target groups Waste Water Technology / Water Pollution Con- Environmental Management; Nature Conservation; Cell biologists, molecular biologists, molecular ge- trol / Water Management / Aquatic Pollution; Ap- Environmental Computing/Environmental Mod- neticists, microbiologists, biochemists plied Ecology; Nature Conservation; Limnology elling Type of publication Target groups Target groups Contributed volume Researchers, environmental managers, graduate stu- Graduate and advanced undergraduate students, re- dents, upper-level undergraduates searchers, resource managers, and policy makers Due June 2008 Type of publication Type of publication Reference work Graduate/advanced undergraduate textbook 2008. Approx. 480 p. 96 illus. 1 in color (Methods in Molecular Biology, Vol. 445) Hardcover Due December 2007 Due July 2008 76,95 € ISBN 978-1-58829-853-9 2008. Approx. 330 p. (Springer Series on Environmental Manage- 2008. Approx. 250 p. 250 illus., 150 in color. Hardcover ment) Hardcover

99,35 € 69,95 € ISBN 978-0-387-76766-6 ISBN 978-0-387-35298-5 32 Life Science springer.com/booksellers

A. Deutsch, Technical University of Dresden, Germany; R. Bra- Due November 2007 vo de la Parra, University of Alcala, Madrid, Spain; R.J. de Boer, Utrecht University, The Netherlands; O. Diekmann, Utrecht Uni- versity, The Netherlands; P. Jagers, Chalmers University of Tech- Volume II of a two-volume set. Volume I ISBN: nology, Göteborg, Sweden; E. Kisdi, University of Helsinki, Fin- 978-0-8176-4557-1. land; M. Kretzschmar, University of Bielefeld, Germany; P. Lansky, Academy of Sciences of the Czech Republic, Prague, Czech Re- public; H. Metz, University of Leiden, The Netherlands (Eds.) 2008. XVIII, 390 p. 119 illus. (Modeling and Simulation in Science, Engineering and Technology) Hardcover Mathematical Modeling of 89,90 € Biological Systems, Volume II ISBN 978-0-8176-4555-7

Epidemiology, Evolution and Ecology, Immunology, Neural Systems and the Brain, and Innovative Mathematical Methods

Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of- the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. High- lighted throughout the work are mathematical and computational approaches to solving central problems in the life sciences, ranging from the organizational principles of individual cells to the dynamics of large populations. The chapters are themati- cally organized into the following main areas: Epi- demiology, Evolution and Ecology, Immunology, Neural Systems and the Brain, Innovative Mathe- matical Methods and Education. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.

Features Unified presentation of mathematical modeling in the biological sciences Presents state-of-the-art mathematical modeling and simulation techniques needed to examine central problems in the life sciences Covers a diverse range of subjects having real-world applications to epidemiology, evolution, ecology, immunology, and neurology For a broad audience of researchers, practitioners, and advanced students in [..]

Contents Preface.- Part I. Epidemiology.- Could Low-Effica- cy Malaria Vaccines Increase Secondary Infections in Endemic Areas?.- Modeling of the Invasion of a Fungal Disease Over a Vineyard.- Algorithm for Pa- rameter Estimation in Nosocomial Infections.- Part II. Evolution and Ecology.- Evolutionarily Stable In- vestment in Anti-Predatory Defences and Aposemat- ic Signalling.- The Tangled Nature Model of Evolutionary Ecology: An Overview.- Relative Advantage and Fundamental Theorems of Natural Selection.- Competitive Exclusion Between Year- Classes in a Semelparous Biennial Population.- On [..]

Fields of interest Mathematical Biology in General; Mathematical Modeling and Industrial Mathematics; Computa- tional Biology/Bioinformatics; Immunology; Epi- demiology; Applications of Mathematics

Target groups Researchers, practitioners, and advanced students in applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics

Type of publication Reference work springer.com/booksellers Life Science 33

K. Dill, CombiMatrix Corp, Mukilteo, WA, USA; R. Liu, CombiMa- M.J. Dilworth, Murdoch University, Perth, Australia; E.K. James, P. Dion, University Laval, Quebec, Canada; C.S. Nautiyal, Nat Bot trix Corp, Mukilteo, WA, USA; P. Grodzinsky, National Cancer In- University of Dundee, UK; J.I. Sprent, University of Dundee, UK; Res Inst, Lucknow, India (Eds.) stitute, Bethesda, MD, USA (Eds.) W.E. Newton, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Eds.) Microbiology of Extreme Soils Microarrays Nitrogen-fixing Leguminous Preparation, Microfluidics, Detection Methods, and Biological Symbioses Applications This volume provides a comprehensive coverage of the principal extreme soil ecosystems of natural and anthropogenic origin. Extreme soils oppose chemical Combinatorial chemistry is used to find materials Nodules produced on legume roots by root-nodule or physical limits to colonization by most soil organ- that form sensor micoarrays. This book discusses the bacteria provide the major nitrogenous input into isms and present the microbiologist with exciting op- fundamentals, and then proceeds to the many appli- natural and agricultural systems worldwide. portunities. Described here are fascinating environ- cations of microarrays, from measuring gene expres- This book provides an in-depth and up-to-the ments, such as permafrost, saline, arid and geother- sion (DNA microarrays) to protein-protein interac- minute analysis of what is known about this sym- mal soils, peatlands, subsurface geomaterial rich in tions, peptide chemistry, carbodhydrate chemistry, biosis, its origins, the process of nodule formation sulfidic ore, Martian soils, hydrocarbon-contaminat- electrochemical detection, and microfluidics. and development, and the biochemistry and genetics ed hot desert and Antarctic soils, as well as fire-im- of nodular nitrogen fixation. It also reviews pacted, heavy-metal and radionuclide contaminat- Features the physiology of the root-nodule bacteria them- ed soils. Those environments lend themselves both Application of combinatorial chemistry to sensor selves, their ecology in both natural and agricultur- to timely descriptions of colonizing organisms and materials No competition whatsoever One of the first al systems, and how we go about introducing new their activities, and to thoughtful examination of books in the series Integrated Microanalytical Sys- legumes and the bactria they require. How all community structure and microbial evolution. Ex- tems the knowledge gained about this system can be ap- treme soils provide invaluable examples of microbial plied in the future for better legume-rhizobia func- adaptations in coping with hostile habitats. Being Contents tioning in difficult environments is its logical culmi- home to a remarkable diversity, they are ideal mod- Types of arrays currently available.- Optical methods nation. els for scientific exploration and propose solutions to of detection of events on the chip surface.- Electro- biotechnology and bioremediation challenges. chemical Detection.- Integrated Microfluidic Devices Features for Automating DNA Microarray Process.- Self-con- This volume provides an in-depth and up-to-the Features tained, Fully Integrated Biochip for Sample Prepara- minute analysis of what is known about this symbio- Includes chapters on basic research in addition to tion, PCR Amplification, and DNA Microarray De- sis, its origins, the process of nodule formation and applications in biotechnology and bioremediation tection.- Spot identification and data evaluation.- development, and the biochemistry and genetics of Statistical data analysis.- Electrochemical output and nodular nitrogen fixation This volume reviews the Fields of interest data analysis.- Uses of DNA Microarrays.- Peptide physiology of the root-nodule bacteria themselves, Microbiology; Microbial Ecology; Agriculture; Soil Arrays: towards Routine Implementation.- Antibody their ecology in both natural and agricultural sys- Science & Conservation; Ecosystems; Astrobiology Microarrays for the Detection of Toxins.- Autoanti- tems, and how we go about introducing new legumes Target groups body Profiling Using Synovial [..] and the [..] Researchers and advanced students in microbiology, Fields of interest Contents soil biology, environmental protection and biotech- Analytical Chemistry; Biotechnology; Biochemical Preface to the Series, Preface, List of Contributors, nology Engineering; Electrochemistry; Process and Chem- Dedication 1. Evolution and Diversity of Legume Type of publication ical Engineering; Characterization and Evaluation Symbiosis: J. I. Sprent 1. Introduction2. The Diversi- Contributed volume Materials ty of Legume Nodules 3. The First 700 Million Years 4. The Last 60 Million Years 5. The Present 6. Con- Target groups clusions References 2. Ecology of Root-nodule Bacte- Due November 2007 Chemists and engineers in industry and academia, ria of Legumes: P. H. Graham 1. Introduction2. Tax- graduate students onomy of Root-nodule Bacteria3. Population Struc- 2008. Approx. 360 p. 48 illus., 9 in color. (Soil Biology, Vol. 13) ture of Rhizobia in Soil and Rhizosphere4. Above Hardcover Type of publication and Below Ground Diversity and Symbiotic Func- Monograph tion5. Strain Competitiveness, Rhizosphere Colo- 149,95 € nization, and Persistence6. Edaphic Factors [..] ISBN 978-3-540-74230-2 Due December 2007 Fields of interest Life Sciences, general; Agriculture; Plant Sciences 2007. Approx. 400 p. (Integrated Microanalytical Systems) Hard- cover Target groups 76,95 € Researchers at universitites, in industry, professional ISBN 978-0-387-72716-5 post-graduate and undergraduate, Basic or applied levels of interest in legumes, scientists working with root nodule bacteria or host legumes, agronomists, forestry scientists, soil scientists

Type of publication Contributed volume

Due December 2007

2007. Approx. 400 p. (Nitrogen Fixation: Origins, Applications, and Research Progress, Vol. 7) Hardcover

129,00 € ISBN 978-1-4020-3545-6 34 Life Science springer.com/booksellers

N. Dobretsov, Institute of Geology and Mineralogy, Novosibrisk, H. Dolman, Vrije Universiteit, Amsterdam, The Netherlands; R. L. Duchateau, Ghent University, Merelbeke, Belgium; P. Janssen, Russia; N. Kolchanov, Institute of Cytology and Genetics, Novosi- Valentini, University of Tucsia, Viterbo, Italy; A. Freibauer, Max Limburgs Universitair Centrum, Diepenbeek, Belgium birsk, Russia; A. Rozanov, Paleontological Institute of the Russian Planck Institute, Jena, Germany (Eds.) Academy of Sciences, Moscow, Russia; G. Zavarzin, Winogradsky Institute of Microbiology of the Russian Academy of Sciences, The Frailty Model Moscow, Russia (Eds.) The Continental-Scale Greenhouse Gas Balance of Europe Biosphere Origin and Evolution Clustered survival data are encountered in many scientific disciplines including human and veterinary This book assesses the current greenhouse gas medicine, biology, epidemiology, public health and demography. Frailty models provide a pow- This monograph contains articles based on the oral (GHG) monitoring capabilities of Europe, identifies erful tool to analyse clustered survival data. In con- presentations given at the International Workshop and quantifies the uncertainties involved, and out- trast to the large number of research publications on on the Bioshphere Origin and Evolution (BOE 2005) lines the direction to a continental scale GHG mon- frailty models, relatively few statistical software pack- held in Novosibirsk, Russia, June 26-29, 2005. The itoring network. The chapters provide a synthesis, ages contain frailty models. It is demanding for sta- organizers of the event was the Scientific Programme based on current research results, of the European tistical practitioners and graduate students to grasp of the Presidium of the Russian Academy of Sciences greenhouse gases budget, including both human-in- a good knowledge on frailty models from the exist- The Biosphere Origin and Evolution, which involves duced and biospheric sources and sinks. The authors ing literature. This book provides an in-depth dis- 50 institutes of the Russian Academy of Sciences. also make recommendations for a multi-disciplinary integration in order to provide the scientific founda- cussion and explanation of the basics of frailty mod- Features tion for a full carbon, and possibly full greenhouse, el methodology for such readers. The discussion in- Contains articles based on the oral presentations giv- accounting system by 2010. Through the CarboEu- cludes parametric and semiparametric frailty mod- en at the International Workshop on the Bioshphere rope project, Europe is taking the lead in much of els and accelerated failure time models. Common Origin and Evolution (BOE 2005) this research, and it will be of interest to techniques to fit frailty models include the EM-algo- other areas of the world as well. The book uniquely rithm, penalised likelihood techniques, Laplacian in- Contents addresses both the methodology of carbon cycle sci- tegration and Bayesian techniques. More advanced Preface.- Problems of Biosphere Evolution and Ori- ence and the science itself. Rather than being frailty models for hierarchical data are also included. gin of Life.- Early Stages of Life Origin and Evolu- a straight methods book, it is a synthesis of carbon Real-life examples are used to [..] tion .- Microbial Biosphere .- Prebiological Stages of cycle science. The methods included are valu- Features Evolution and Rna World on the Earth and in the able, but are used to contribute to an [..] Space .- Astrocatalysis Hypothesis for Origin of Life Introduces Frailty Models from a basic level that is Problem .- Comets, Carbonaceous Meteorites, and Features missing in other books the Origin of the Biosphere.- Hierarchical Scale-Free Provides thorough assessment of the current green- Contents Representation of Biological Realm, Its Origin and house gas (GHG) monitoring capabilities of Europe Introduction.- Parametric Proportional Hazards Evolution.- The Prebiotic Phase of the Origin of Life Makes practical recommendations for the develop- Models With Gamma Frailty.- Alternatives for the as it is Seen by A Physical Chemist.- Prebiotic Car- ment of a continental-scale GHG monitoring net- Frailty Model.- Frailty Distributions.- The Semipara- bohydrates and their Derivates.- Theoretical and work A unique synthesis of carbon cycle science metric Frailty Model.- Multi-Frailty and Multilevel Computer Modeling of [..] Contents Models.- Extensions of the Frailty Model. Fields of interest Introduction: CarboEurope GHG and goals of the Fields of interest Evolutionary Biology book.- Methods and requirements for a global car- Statistics for Life Sciences, Medicine, Health Sci- bon data assimilation schemes.- Optimiz- ences; Cancer Research; Simulation and Modeling; Target groups ing the observation network.- Improving model Biometrics; Infectious Diseases; Epidemiology Molecular biologists, geneticists, geologists, palaeon- parameters from sparse observations.- Ef- tologists, archaeologists, chemists, evolutionists, fective sampling of soil carbon at European scale.- Target groups ecologists, bioinformaticians and mathematicians in- Effective sampling of ecosystem fluxes: a bot- Statisticians, graduate students volved in basic and applied research in the fields of tom up perspective.- Full GHG accounting of experimental, theoretical and computational stud- grasslands.- Observation of CH4 emissions Type of publication ies of micro- and macro-evolutionary processes, evo- from wetlands.- State of the art carbon in- Monograph lution and co-evolution of mineral and biological ventories and ways to use them for carbon cycle re- worlds, the origin of molecular genetic systems oper- search.- Lateral C-fluxes.- Top down Due December 2007 ating in living organisms; and to lecturers of univer- constraints from [..] sities and colleges Fields of interest 2008. XIV, 314 p. (Statistics for Biology and Health) Hardcover Type of publication Ecology; Atmospheric Protection/Air Quality Con- Contributed volume trol/Air Pollution; Environmental Management; Cli- 64,95 € mate Change ISBN 978-0-387-72834-6 Due January 2008 Target groups Researchers, graduate students 2008. Approx. 655 p. Hardcover Type of publication 114,95 € Reference work ISBN 978-0-387-68655-4

Due February 2008

2008. Approx. 305 p. 100 illus. (Ecological Studies, Preliminary entry 900) Hardcover

ISBN 978-0-387-76568-6 springer.com/booksellers Life Science 35

S. Dudoit, University of California, Berkeley, CA, USA; M.J. van der A. Economou, University of Crete, Iraklio, Crete, Greece (Ed.) C.A. Edwards, The Ohio State University, Columbus, OH, USA; P.J. Laan, University of California, Berkeley, CA, USA Bohlen, MacArthurAgro-Ecology Research Center, Lake Placid, FL. USA; P. Hendrix, University of Georgia, Athens, GA, USA; N. Protein Secretion Arancon, The Ohio State University, Columbus, OH, USA Multiple Testing Procedures with Applications to Genomics Biology and Ecology of Earthworms The purpose of this volume is to provide examples of the multiplicity of tools that have been developed to study protein sorting, membrane targeting, trans- This book establishes the theoretical foundations of a This 4th edition updates the latest research on earth- membrane crossing and secretion across multiple general methodology for multiple hypothesis testing worms. More than 3,000 species of earthworm exist membranes. A wide range of methods is covered that and discusses its software implementation in R and in the world. They are considered to be an important range from bioinformatics and proteomics to fun- SAS. The methods are applied to a range of testing ally in advancing environmental and biomedical re- damental enzymology and genetics to cell biology, problems in biomedical and genomic research, in- search. Earthworms play an important role in for- structural analyses and biophysics. This only reflects cluding the identification of differentially expressed est or agricultural ecosystems and play an increasing the highly multidisciplinary nature one expects from and co-expressed genes in high-throughput gene role in biomedical issues. Earthworms are critical to a mature field. Moreover, the biotechnological po- expression experiments, such as microarray experi- the environment because they consume huge quanti- tential of secretion systems is also discussed with ex- ments; tests of association between gene expression ties of decomposed litter, manure, and other organ- amples of manipulation of protein export pathways measures and biological annotation metadata (e.g., ic matter deposited on soil -- helping to convert it infor the production of heterelogous proteins (be they Gene Ontology); sequence analysis; and the genetic to rich topsoil Earthworms can also help reduce soil biopharmaceuticals or industrial enzymes) as well as mapping of complex traits using single nucleotide compaction, improve permeability--thus providing their use to develop vaccines and antimicrobials. It is polymorphisms. The book is aimed at both statisti- channels for root growth, water infiltration, and gas hoped that study of the various systems and the tools cians interested in multiple testing theory and ap- exchange. Earthworms are also important animals developed to decipher their secrets will provide users plied scientists encountering high-dimensional test- for the assessment of the toxicity of chemicals, such with inspiration in finding ways to tackle problems ing problems in their subject matter area. Specifical- as herbicides and pesticides, which are deliberately encountered in their research. ly, the book proposes resampling-based single-step released into the environment. Earthworms are su- and stepwise multiple testing procedures for control- Fields of interest perb ‘barometers' or ‘sentinels' providing an early ling a broad class of Type I error rates, defined as tail Cell Biology; Proteomics; Biochemistry, general warning of deterioration in soil quality. probabilities and expected values for [..] Target groups Features Features Biochemists, geneticists, cellular biologists, molecu- First three editions served as the standard text in the This book provides a detailed account of the theoret- lar biologists, and structural biologists field Eleven years since last edition ical foundations of proposed multiple testing methods and illustrates their application to a range of test- Type of publication Contents ing problems in genomics Contributed volume Preface.- Earthworm Morphology.- Earthworm Bio- diversity and Biogeography.- Earthworm Biology.- Contents Earthworm Physiology.- Earthworm Ecology: Pop- Due October 2009 Multiple hypothesis testing.- Test statistics null dis- ulations.- Earthworm Ecology: Communities.- The tribution.- Overview of multiple testing procedures.- Influence of Environmental Factors on Earthworms.- Single-step multiple testing procedures for control- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary The Role of Earthworms in Organic Matter and Nu- ling general Type I error rates.-Step-down entry 2272) Hardcover trient Cycles.- Earthworms and Micro-Organisms.- multiple testing procedures for controlling the fam- Role of Earthworms in Soil Structure, Fertility and 76,65 € ily-wise error rate.- Augmentation multiple testing Productivity.- Earthworms as Pests and Benefactors.- ISBN 978-1-60327-167-7 procedures for controlling generalized tail probabil- Earthworms in Environmental Management.- Effects ity error rates.- Resampling-based empirical Bayes of Agricultural Practices and Chemicals on Earth- multiple testing procedures for controlling general- worms.- Appendix: Summary of Results on Labora- ized tail probability error rates.- Simulation studies: tory and [..] Assessment of test statistics null distributions.- Iden- tification of [..] Fields of interest Ecology; Animal Ecology; Environmental Manage- Fields of interest ment; Waste Management/Waste Technology; Inver- Bioinformatics; Statistical Theory and Methods; tebrates Statistics for Life Sciences, Medicine, Health Sciences Target groups Target groups Students and researchers in soil science and environ- Researchers mental management

Type of publication Type of publication Monograph Monograph

Due December 2007 Due January 2009

2007. Approx. 585 p. (Springer Series in Statistics) Hardcover Originally published by Chapman & Hall, 1996 69,95 € ISBN 978-0-387-49316-9 2009. Approx. 530 p. Softcover 76,20 € ISBN 978-0-387-74942-6 36 Life Science springer.com/booksellers

D. Edwards, La Trobe University, Victoria, Australia (Ed.) R. Egel, Institute of Molecular Biology and Physiology, Copen- S. Eguchi, University of Nagoya, Japan (Ed.) hagen, Denmark; D.-H. Lankenau, Ladenburg, Germany (Eds.) Plant Bioinformatics Bioactive Heterocycles II Recombination and Meiosis Methods and Protocols Crossing-Over and Disjunction

Features This book aims to assist research scientists in choos- Heterocyclic chemistry is the biggest branch of ing the most applicable database or bioinformat- Once per life cycle, mitotic nuclear divisions are re- chemistry covering two-third of the chemical litera- ics tools to aid and promote their research in plant placed by meiosis I and II – reducing chromosome ture Covers hot topics of frontier research summa- biotechnology. Chapters include practical examples number from the diploid level to a haploid genome, rized by reputed scientists in the field Our review and highlight common problems encountered in reshuffling the homologous chromosomes by their series is topic related Online version available on bioinformatics analysis. Further chapters are aimed centromeres, and recombining chromosome arms SpringerLink.com at researchers developing bioinformatics databases by crossing-over. In animals, including humans, all and tools, detailing commonly applied database for- this happens during the germ cell formation of eggs Contents mats and biology-focused scripting languages. These and sperm. Due to the reign of meiosis, no child is a K. Matsumoto: High Pressure Synthesis of Hetero- will provide both beginners and experienced bioin- true genetic copy of either parent. Central to main- cycles Related to Bioactive Molecules.- N. Nishiwa- formatics researchers with the necessary skills to de- stream meiosis, the mechanisms of reciprocal ex- ki, M. Ariga: Ring Transformation of Nitropyrim- velop and apply bioinformatics tools for their spe- change at crossover/chiasma sites stand out as a con- idinone Leading to Versatile Azaheterocyclic Com- cialist area of plant research. trolled program of biologically significant molecular pounds.- N. Shibata, T. Yamamoto, T. Toru: Synthe- changes. To initiate the meiotic exchange of DNA, sis of Thalidomide.- H. Nagase, H. Fujii: Rational Features surgical cuts are made as a form of calculated dam- Drug Design of d Opioid Receptor Agonist TAN-67 Aims to assist research scientists in choosing the age that is subsequently repaired by homologous re- from d Opioid Receptor Antagonist NTI.- S. Murata, most applicable database or bioinformatics tools to combination. These key events are accompanied by H. Ichinose, F. Urano: Tetrahydrobiopterin and Re- aid and promote their research in plant biotechnolo- ancillary provisions at the level of chromosome core lated Biologically Important Pterins.- M. Yamashita: gy Chapters include practical examples and highlight organization, sister chromatid cohesion, and differ- Preparation, Structure and Biological Property of common problems encountered in bioinformatics ential centromere connectivity. Great progress has Phosphorus Heterocycles with a C-P Ring System.- analysis been made in recent years to further our [..] [..]

Contents Features Fields of interest The EMBL Nucleotide Sequence and Genome Re- First book to give a detailed insight in the process- Organic Chemistry; Biochemistry, general; Medici- views Databases.- Using GenBank.- A Collection of es and mechanisms taking place in the cell during nal Chemistry Plant-Specific Genomic Data and Resources at the meiosis and recombination Written by high-impact National Center for Biotechnology Information.- authors from the field Target groups UniProtKB/Swiss-Prot, the manually annotated sec- Scientists and practitioners in the mentioned fields tion of the UniProt KnowledgeBase.- Plant Database Contents and in industry Resources at The Institute for Genomic Research.- Meiotic Crossing-over and Disjunction: Overt and MIPS Plant Genome Information Resources (Plants- Hidden Layers of Description and Control.- Chro- Type of publication DB).- HarvEST: an EST database-and viewing soft- matid Cores, Meiotic Chromosome Structure and Reviews ware.- The TAIR Database.- AtEnsembl - A post-ge- Segregation.- Sister Chromatid Cohesion and Cen- nomic resource browser for Arabidopsis.- Accessing tromere Organization in Meiosis.- Spo11 and the Due November 2007 integrated Brassica genetic and genomic data using Formation of DNA Double-Strand Breaks in Meio- the BASC [..] sis.- Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females.- Synap- 2007. XII, 309 p. Also available online. (Topics in Heterocyclic Chemistry, Vol. 8) Hardcover Fields of interest tic and Recombination Nodules in Mammals: Struc- Plant Sciences; Bioinformatics tural Continuity with Shifting Protein Composition.- 229,00 € Human Recombination Hotspots: Before and after ISBN 978-3-540-72591-6 Target groups the HapMap Project.- Meiotic Nondisjunction – the Plant biologists, geneticists, molecular and cellular Major Cause of [..] biologists, computational biologists and bioinformaticians Fields of interest Cell Biology; Biochemistry, general; Animal Genetics Type of publication and Genomics; Human Genetics; Plant Genetics & Contributed volume Genomics

Due November 2007 Target groups Cell biologists, biochemists

2007. Approx. 640 p. 179 illus. (Methods in Molecular Biology, Type of publication Vol. 406) Hardcover Reference work 109,95 € ISBN 978-1-58829-653-5 Due November 2007

2008. Approx. 360 p. 38 illus., 14 in color. (Genome Dynamics and Stability, Vol. 2) Hardcover

179,95 € ISBN 978-3-540-75371-1 springer.com/booksellers Life Science 37

E. Eich, Freie Universität Berlin, Germany W. El-Sharoud, Mansoura University, Mansoura, Egypt (Ed.) Y. Elad, The Volcani Center, Bet Dagan, Israel; B. Williamson, Scot- tish Crop Research Institute, Dundee, UK; P. Tudzynski, Institut für Botanik, Münster, Germany; N. Delen, Ege University, Izmir, Solanaceae and Convolvulaceae: Bacterial Physiology Turkey (Eds.)

Secondary Metabolites A Molecular Approach Botrytis: Biology, Pathology and Biosynthesis, Chemotaxonomy, Biological and Economic Sig- nificance (A Handbook) Control The application of new molecular methodologies in the study of bacterial behaviour and cell architecture has enabled new revolutionary insights and discov- This comprehensive and interdisciplinary hand- Botrytis cinerea and other Botrytis species are im- eries in these areas. While this has also raised a num- book provides a bird’s-eye view of two centuries of portant pathogens of nursery plants, vegetables, or- ber of scientific mysteries about bacteria, it certainly research on secondary metabolites of the two large namental, field and orchard crops and stored and improved our understanding of these organisms as Solanales families, Solanaceae and Convolvulaceae. transported agricultural products. Over the last 125 complex and adaptive entities rather than just sim- Arranged according to their biosynthetic principles, years, Botrytis spp. have been investigated by an in- ple tiny buckets of enzymes. The value of this recent the occurrence and chemical structures of almost creasing number of specialists in diverse fields in- knowledge in bacterial physiology is not only re- all known individual secondary metabolites are cov- cluding chemistry, biochemistry, molecular and cell stricted to fundamental biology, but it also extends to ered, which are found in hundreds of wild as well as biology, genetics, morphology and histology, tax- biotechnology and drug-discovery disciplines where cultivated solanaceous and convolvulaceous species. onomy, host-parasite interaction, ecology and epi- understanding cell behaviour and structure is essen- In addition to the biosynthesis, the pharmacolog- demiology and they have been the subject of an im- tial for better exploitation of useful bacteria and ef- ical, toxicological, ethnobotanical, ecological, and mense number of published studies. Considerable effective eradication of harmful ones. This makes a economic significance of the metabolites is treated. fort is invested in protecting the agricultural produce new text accommodating recent developments in A major aim of this book is the individual phyto- against Botrytis before and after harvest. The market bacterial physiology highly relevant to a wide range chemical characterization of the Solanales taxa on size for anti-Botrytis products is currently estimated of readership including those interested in basic and the species level. Species are integrated into frame- at US$ 15-25 million in recent years. The intensity of applied knowledge. works of traditional and molecular phylogeny-based anti-Botrytis measures taken by farmers continued classifications. This allows a detailed discussion of Features unabated throughout the last 20 years but our under- chemotaxonomic relationships with regard to all tax- Highlights recent discoveries and theories in bacteri- standing of the processes that govern Botrytis life cy- on levels up to the order. The text is supplemented al physiology Chapters are written by international cles, pathogenicity and epidemiology have become by 83 superb color photos of Solanales plants. scientific authorities leading research at the forefront comprehensive. During the [..] of bacterial physiology Features Features With 16 beautiful color plates showing Solanales Contents Written by leading scientists in the Botrytis sci- plants The author, Prof. Eckart Eich, has over 20 Subcellular Organisation in Bacteria.- Molecu- ences Includes detailed reviews of Botrytis spp. and years experience in research of secondary metabo- lar Components of the Bacterial Cytoskeleton.- the diseases they cause in plant systems and pro- lites of Solanales A comprehsive handbook which for Mechanosensitive Channels: their Mechanisms and vides a comprehensive description of these fungal the first time covers all aspects of these plant fami- Roles in Preserving Bacterial Ultrastructure during necrotrophs This book adopts a multidisciplinary lies, which include many species of great pharmaco- Adaptation to Environmental Changes.- Structural approach to integrate the state-of-the-art knowledge logical and economic importance and Functional Flexibility of Bacterial Respiromes.- in all key areas of common interest in the fungi and their plant interactions Fields of interest Protein Secretion in Bacterial Cells.- The Regulation of Transcription in Bacteria by DNA Supercoiling.- Plant Systematics/Taxonomy/Biogeography; Plant Contents Quorum Sensing.- Environmental Sensing and the Biochemistry; Pharmacology/Toxicology; Pharmacy; From the contents Preface.- Acknowledgements.- Role of Extracytoplasmic Function (ECF) Sigma Fac- Agriculture Contributors.- 1. Botrytis spp. and diseases they tors.- Extracellular Sensors and Extracellular Induc- cause in agricultural systems – an introduction.- 2: tion Components in Stress Tolerance [..] Target groups The Ecology of Botrytis on Plant Surfaces.- 3. Tax- Scientists in botany, taxonomy, organic chemistry, onomy and Genetic Variation of Botrytis and Botry- phytochemistry, microbiology, food chemistry, agri- Fields of interest Microbiology; Bacteriology; Medical Microbiology; otinia.- 4. Approaches to Molecular Genetics and culture, horticulture, pharmacognosy, pharmacology Genomics of Botrytis.- 5. Morphology and Cellular and toxicology Applied Microbiology; Microbial Ecology; Biochem- istry, general Organisation in Botrytis Interactions with Plants.- 6. Signalling in Botrytis cinerea.- 7. Extracellular En- Type of publication zymes and Metabolites Involved in Pathogenesis of Handbook Target groups Microbiologists, bacteriologists Botrytis.- 8. Botrytis cinerea Perturbs Redox Process- es as an Attack Strategy in [..] Due November 2007 Type of publication Reference work Fields of interest 2008. Approx. 600 p.190 illus., 83 in color Hardcover Plant Pathology Due December 2007 199,95 € Target groups ISBN 978-3-540-74540-2 Scientists in the Botrytis sciences; researchers and 2008. Approx. 435 p. 51 illus., 8 in color. Hardcover students, farm advisers and agriculture specialists

199,95 € Type of publication ISBN 978-3-540-74920-2 Contributed volume

Due October 2007

2007. XIX, 428 p. Softcover

64,95 € ISBN 978-1-4020-6586-6 38 Life Science springer.com/booksellers

R. Elber, Cornell University, Ithaca, NY, USA Y. Endo, Ehime University, Matsuyama, Japan (Ed.) M.D. Evans, University of Leicsester, UK; M.S. Cooke, University of Leicsester, UK (Eds.) Protein Modeling with Cell-free Expression Systems Bioinformatics and Biophysics Oxidative Damage to Nucleic Acids

Fields of interest This book provides an up-to-date coverage of select- At the core of biological complexity are the small Cell Biology; Proteomics; Biochemistry, general; ed topics in the area of nucleic acid oxidation. The machines that maintain the whole: the protein Biotechnology topics have been selected to cover everything from molecules. Proteins are encoded by DNA sequences, basic chemical mechanisms, repair of damage and spontaneously adopt unique three-dimensional Target groups the biological and pathological meaning of DNA ox- shapes, and perform a wide range of biological func- Biochemists, molecular biologists, and biotechnolo- idation. The chapters are authored by leading, re- tions in living systems. Scientists from a broad range gists search active, international experts in the respective of disciplines are fascinated by these biological ma- topics. In addition to some of the traditionally cov- chines and use computational means to study the Type of publication ered topics, we have included some areas that receive evolution, biophysical properties and biological con- Contributed volume less attention in similar volumes, for example chap- text of proteins. This book discusses the interface be- ters focusing on damage to nucleic acids by halo- tween the different disciplines and the mixed sets of Due September 2009 genating and nitrating species, gene-specific dam- theoretical and computational methods used by each age, telomere shortening and damage to promoter to study proteins. Tools vary from machine learning regions. Through this approach, we recognize addi- and statistical methods to text matching and identifi- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary entry 2250) Hardcover tionally the importance of nucleic acid damage be- cation of homologous proteins, to statistical physics yond mutation and in pathological conditions oth- formulation of random energies and protein folding, 76,65 € er than carcinogenesis. The primary audience for and to molecular dynamic simulations of proteins in ISBN 978-1-60327-330-5 the book would be research scientists and advanced action. Protein Modeling with Bioinformatics and postgraduate students, the book may also be of inter- Biophysics will benefit scientists and advanced-level est to clinicians with strong research interests. We students interested in this [..] [..] Features Features Interdisciplinary approach to computational study of Provides a comprehensive and detailed analysis of proteins, based on notions from computer science, the topic of nucleic acid oxidation from the perspec- physics, chemistry and biology, offers an especially tives of basic science and biological relevance broad perspective on the field Traditionally proteins were studied on the sequence, structure, or dynami- Contents cal and functional levels Outlines a complete hierar- Oxidatively Generated Damage to Cellular DNA: chy of theoretical and computational studies used to Mechanistic Aspects.- Chlorination and Nitration of study proteins by researchers from different fields DNA and Nucleic Acid Components.- Prevention of the Mutagenicity and Cytotoxicity of Oxidized Contents Purine Nucleotides.- Nucleotide Incision Repair: The Darwin approach to proteins: Protein fami- An Alternative and Ubiquitous Pathway to Handle lies (function, structure, and sequence). Protein se- Oxidative DNA Damage.- OGG1: From Structural quences. Introduction to Protein structures. Fold Analysis to the Knockout Mouse.- Processing of 3'- recognition. Statistical mechanics of sequence space.- End Modified DNA Strand Breaks Induced by Ox- The Boltzmann approach to proteins: The hy- idative Damage.- Oxidative Damage and Promoter drophobic force. Modeling protein energy and ther- Function.- Oxidative DNA Damage and Telomere modynamics. Ab-initio protein folding. Kinetics.- Shortening.- Oxidative Damage and Repair in the Index. Mitochondrial Genome.- [..] Fields of interest Fields of interest Simulation and Modeling; Bioinformatics; Theoreti- Biochemistry, general cal and Computational Chemistry; Mathematical Bi- ology in General; Mathematical and Computational Target groups Physics; Computer Applications in Chemistry Researchers and advanced postgraduate students in the areas of Genotoxicology, DNA Repair, and Target groups Molecular Pathology Research scientists Type of publication Type of publication Contributed volume Monograph

Due October 2007 Due July 2008

2008. Approx. 245 p. 74 illus., 7 in color. Hardcover 2008. Approx. 350 p. 20 illus. Hardcover 124,95 € 74,95 € ISBN 978-0-387-72973-2 ISBN 978-0-387-32988-8 springer.com/booksellers Life Science 39

S. Even-Ram, Hadassah Hebrew University Hospital, Jerusalem, M. Fatmi, Institut Agronomique et Vétérinaire Hassan II, Agadir, M. Fernanda Suarez, University of Malaga, Malaga, Spain; P. Israel (Ed.) Morocco; A. Collmer, Cornell University, Ithaca, NY, USA; N.S. Ia- Bozhkov, Swedish University of Agricultural Sciences, Upsala, cobellis, Università della Basilicata, Potenza, Italy; J.W. Mansfield, Sweden (Eds.) Imperial College, Wye, Ashford, Kent, United Kingdom; J. Murillo, Extracellular Matrix Protocols Universidad Pública de Navarra, Pamplona, Spain; N.W. Schaad, USDA-ARS, Ft. Detrick, MD, USA; M. Ullrich, International Univer- Plant Embryogenesis sity Bremen, Germany (Eds.)

Fields of interest Pseudomonas syringae Pathovars The advent of the postgenome era has brought a re- Cell Biology and Related Pathogens - markable evolution in modern plant embryology. In Plant Embryogenesis, the authors focus on the Type of publication Identification, Epidemiology and common developmental process and compile novel Contributed volume Genomics tools and methods designed specifically for studying plant embryogenesis. In each chapter, detailed out- Due July 2008 lines of model embryonic systems are provided, as well as cutting-edge cellular, genetic and molecular mechanisms. This important book gives insight into 2008. Approx. 300 p. (Methods in Molecular Biology, Preliminary Fields of interest the methods used in studying the transformation of entry 2032) Hardcover Plant Pathology; Bacteriology; Plant Genetics & Ge- phylogenetically-conserved embryonic patterns into nomics 74,95 € flora’s astounding diversity of growth forms today. ISBN 978-1-58829-984-0 Target groups Invaluable to those new to the field and inspiring to Researchers in the field of plant pathology, plant bac- full-fledged plant embryologists, Plant Embryogene- teriologists, plant-microbe molecular biologists, cell- sis provides today’s most comprehensive platform to microbe biologists, Master and PhD students. the understanding of plant embryo development.

Type of publication Features Contributed volume Step-by-step reproducible laboratory procedures written by the top experts in the field offering their time-tested hints, tricks, and tips Presents detailed Due January 2008 outlines of embryonic systems models along with cutting-edge cellular, genetic, and molecular mecha- 2008. Approx. 650 p. Hardcover nism Provides the most comprehensive collection of protocols on plan embryo development 249,00 € ISBN 978-1-4020-6900-0 Contents Arabidopsis embryogenesis.- Maize embryogenesis.- Spruce embryogenesis.- In vitro fertilization with isolated higher plant gametes.- In vitro culture of Arabidopsis embryos.- Culture and time-lapse tracking of barley microspore-derived embryos.- Isolation of embryo-specific mutants in Arabidopsis: Plant transformation.- Isolation of embryo-specific mutants in Arabidopsis: Genetic and phenotypic analysis.- Laser-capture microdissection to study global transcriptional changes during plant embryogenesis.- Promoter trapping system to study embryogenesis.- Visualization of auxin gradients in [..]

Fields of interest Plant Sciences; Plant Genetics & Genomics; Plant Biochemistry

Target groups Plant embryologists, molecular and cell biologists, botanists, bioengineers

Type of publication Contributed volume

Due February 2008

2008. Approx. 221 p. 21 illus. (Methods in Molecular Biology, Vol. 427) Hardcover

79,95 € ISBN 978-1-58829-931-4 40 Life Science springer.com/booksellers

J.G. Fleagle, State University of New York, Stony Brook, NY, USA; P.N. Floriano, University of Texas, Austin, TX, USA (Ed.) D.R. Forsdyke, Queen's University, Kingston, ON, Canada; A. Cock C.C. Gilbert, State University of New York, Stony (Eds.) (Eds.) Microchip-Based Assay Systems Elwyn Simons: A Search for Origins The Science and Life of William Methods and Applications Bateson

For nearly a half century, Dr. Simons has dominated the study of primate evolution. The volume sum- Microchip-Based Assay Systems explores recent This is a biography– written in the mode of Abra- marizes the current state of knowledge in many as- progress in the microelectronics arena, the resul- ham Pais’ biography of Einstein: "Subtle is the Lord." pects of primate and human evolution that have been tant miniaturization of component device features The Science and Life of Albert Einstein. There is one studied by Simons and his colleagues and place it to nanometer size particles, and the ensuing growth major difference. Whereas the science in Pais’s text in a broader paleontological and historical perspec- in the development and use of microchip-based tech- was relegated to esoteric small print segments, the tive. Elwyn Simons: A Search for Origins contains niques in leading laboratories around the world. authors highlight evolutionary biology as it is at a the results of new research and reviews of many of While the area of microelectronics is faced with stage where it can be made intelligible to the edu- the critical issues in primate and human evolution daunting challenges, it promises fascinating new ad- cated reader. William Bateson brought the work of during the last half of the twentieth century as well as vances that may translate into products such as sen- Mendel (and much more) to the attention of the En- aspects of African paleontology and primate conser- sors and devices that use nanometer-sized build- glish-speaking world. He commanded the biologi- vation in Madagascar. The authors are an extremely ing blocks for real-world applications. The contrib- cal sciences in the decades after Darwin's death in distinguished group of international authorities on utors to this volume are part of growing interdisci- 1882. He gave twentieth century figures such as J. B. all aspects of primate and human evolution and pri- plinary efforts among pioneers in microelectronics, S. Haldane and C. D. Darlington a start in science, mate behavior. Although linked primarily by their nanoscience, and health that will continue to create and was critical of the emergent Eugenics. We connection to Simons’ own career, the chapters in- exciting new microchip-based applications across provide an understanding of Bateson as well as a rec- clude a wide range of important new works that are a variety of sectors. In the 16 chapters of this vol- onciliation of diverging views (e.g. the hierarchical valuable contributions to the field of physical anthro- ume, leading scientists present technically precise thinking of Gould and the genocentrism of George pology and paleontology and are certain to be widely microchip-based assays for a variety of applications. Williams and Richard Dawkins). Evolutionists may cited and used in teaching. Several of the [..] Features thus, at long last, present a unified front to their cre- Features DNA microchips for diagnosis and molecular sig- ationist opponents. Dr Simons dominated the study of primate evolution natures in cervical cancer Cutting-edge microarray Features for half a century; addresses challenges of teaching applications Integrated protocols utilizing microflu- The pressing need for this text is apparent from the evolution in schools idic chips, devices, and 3-D networks Identification of protein-protein interactions in an array format high percentages reported not to believe in evolution Contents Methods for the detection of HIV RNA interactions and the growth of the so-called "intelligent design" The Life and career of Elwyn Simons.- Elwyn Simons with peptides Microchip-based electrochemical en- movement. So far biohistorians have failed to come and the Synthesis of Two Intellectual Traditions.- zyme immunoassays up with a comprehensive biography of William Bate- Five decades of Research in Egypt.- Ear regions of son. In 1986 William Provine concluded: "Evolution- Aegyptopithecus and Parapithecus: Implications for Contents ary biology in the period 1859-1925 is extraordinary Platyrrhine Origins.- Fossil Plants and Vegetation of Microchip Electrophoresis for DNA Separation by complex". To understand this period we must [..] the Fayum.- Geology, Paleoenvironment, and Age Wire-Imprinted Microchannels on PMMA Sub- Fields of interest of the Oldest Primate-bearing Fossil C. Clyde, and strates.- Fabrication of Porous Polymer Monoliths in Evolutionary Biology; Human Genetics; History of Mark Mathison Locality in the Fayum Depression.- Microfluidic Chips for Selective Nucleic Acid Con- Medicine; Life Sciences, general; Philosophy of Biol- Early Evolution of Whales: Results of A Century centration and Purification.- Rapid Electrical Ly- ogy of Research in Egypt.- Paleogene Mammals from sis of Bacterial Cells in a Microfluidic Device.- On- Chip Bioassay Using Immobilized Sensing Bacteria Sub-Saharan Africa:A View from the eastern Rift.- Target groups in Three-Dimensional Microfluidic Network.- Mi- Searching for New African Frontiers.- [..] Students, educated laypersons, researchers, and bio- crochip-based Enumeration of Human White Blood historians in the fields of evolutionary biology, ge- Fields of interest Cells.- Microchip for the Diagnosis of Cervical Can- netics, developmental biology, cell biology, bioinfor- Evolutionary Biology; Zoology cer.- DNA Microchips Towards Molecular Signa- matics, and biochemistry. tures in Cervical Cancers.- Impedimetric-Detection Target groups for DNA [..] Type of publication Libraries, researchers, scientists, graduate students Contributed volume in the fields of: Evolutionary Biology, Primatology, Fields of interest Physical Anthropology and Animal Science Biotechnology; Cell Biology; Human Genetics Due April 2008 Type of publication Target groups Contributed volume Geneticists, biotechnologists, chemists, biochemists, 2008. Approx. 700 p. 15 illus. Hardcover molecular and cell biologists Due December 2007 46,20 € Type of publication ISBN 978-0-387-75687-5 Contributed volume 2008. Approx. 300 p. (Developments in Primatology: Progress and Prospects) Hardcover Due November 2007 109,95 € ISBN 978-0-387-73895-6 2007. Approx. 275 p. 69 illus., 4 in color. (Methods in Molecular Biology, Vol. 385) Hardcover

79,95 € ISBN 978-1-58829-588-0 springer.com/booksellers Life Science 41

G. Foster, University of Bristol, Bristol, UK; E. Johansen, Danish B.O. Fraser-Reid, Natural Products & Glycotechnology Research B.O. Fraser-Reid, North Carolina State University, Durham, NC, Institute of Agricultural Sciences, Denmark; Y. Hong, University of Institute Inc., Durham, NC, USA; K. Tatsuta, Waseda University, USA; K. Tatsuta, Waseda University, Tokyo, Japan; J. Thiem, Uni- Warwick, Warwick, UK; P. Nagy, University of Kentucky, Kentucky, Tokyo, Japan; J. Thiem, University of Hamburg, Germany (Eds.) versity of Hamburg, Germany; G.L. Coté, National Center Agricul- USA (Eds.) tural Utilization, Peoria, USA; S. Flitsch, University of Manchester, UK; Y. Ito, RIKEN, Saitama, Japan; H. Kondo, Discovery Research Glycoscience Labs., Osaka, Japan; S.-i. Nishimura, Hokkaido University, Sap- Plant Virology Protocols poro, Japan; B. Yu, Chinese Academy of Sciences, Shanghai, Chi- Chemistry and Chemical Biology na (Eds.) From Viral Sequence to Protein Function Glycoscience Glycostructures play a pivotal and crucial role in a Following the considerable success of the first edi- myriad of organisms and important systems in biol- Chemistry and Chemical Biology tion of Plant Virology Protocols, this exciting new ogy, physiology, medicine, bioengineering and tech- edition covers the many new techniques that are now nology. Within recent years tools have been devel- applied to the examination and understanding of oped to promote the understanding of their highly Glycostructures play a pivotal and crucial role in a plant viruses. Each section of Plant Virology Proto- complex functions and the associated chemistry and myriad of organisms and important systems in biol- cols, Second Edition presents the most novel meth- chemical biology, however, many facts still remain ogy, physiology, medicine, bioengineering and tech- ods and protocols to allow researchers more effective undiscovered. These days the area is experiencing a nology. Within recent years tools have been devel- approaches to study plant viruses. The many subjects “quantum jump”. Therefore the Editors in collabo- oped to promote the understanding of their highly covered in this important new edition range from ration with six responsible Section Editors complete- complex functions and the associated chemistry and techniques for investigating viral nucleic acid se- ly revised and updated the 1st edition to give up-to- chemical biology, however, many facts still remain quence, protein analysis and investigation of protein date information on glycostructures, their chemistry undiscovered. These days the area is experiencing a function, techniques for microscopy/GFP visualiza- and chemical biology, and present them in the form “quantum jump”. Therefore the Editors in collabo- tion and analysis/protein tagging/generation of in- of a comprehensive and strictly systematic survey. ration with six responsible Section Editors complete- fectious clones and other such tools, as well as areas The texts are furnished by more than 2500 figures, ly revised and updated the 1st edition to give up-to- of genomics and interactions with host factors and chemical structures and reaction schemes (including date information on glycostructures, their chemistry plant-based studies. Plant Virology Protocols, Sec- more than 12,000 individual chemical reactions), and and chemical biology, and present them in the form ond Edition: From viral sequence to protein function more than 9,000 references. In concept and content of a comprehensive and strictly systematic survey. is indispensable to laboratory investigators studying this Major Reference Work received an essential im- The texts are furnished by more than 2500 figures, plant viruses. provement and expansion. Whereas chapter [..] chemical structures and reaction schemes (including more than 12,000 individual chemical reactions), and Features Features more than 9,000 references. In concept and content Offers step by step reproducible laboratory protocols Completely revised and updated to reflect the “quan- this Major Reference Work received an essential im- written by experts in the field of plant sciences, virol- tum jump” in the field of glycostructures Three new provement and expansion. Whereas chapter [..] ogy, and genomics. Focus on the novel and emerg- chapters on: Key Technology and Tools, Biosynthe- ing techniques used to analyze, understand, and treat sis and Glycomedicine Includes more than 12,000 Features plant viruses Covers the spectrum of plant virology chemical reactions and more than 9,000 references Completely revised and updated to reflect the “quan- protocols, from general introductions to typical plan Available in print and electronic tum jump” in the field of glycostructures Three new viral proteins, techniques for investigating viral acid chapters on: Key Technology and Tools, Biosynthe- sequences, through the emerging area of [..] Contents sis and Glycomedicine Includes more than 12,000 The complete table of contents can be found on the chemical reactions and more than 9,000 references Contents Internet: http://www.springer.de Plant virus interactions.- Role of capsid pro- Available in print and electronic teins.- Role of plant virus movement pro- Fields of interest Contents teins.- Multiple roles of viral replication pro- Organic Chemistry; Biochemistry, general; Molecu- General Principles.- General Synthetic Methods.- teins in plant RNA virus replication.- Role of lar Medicine; Biotechnology; Pharmacology/Toxicol- Chemical Glycosylation Reactions.- Monosaccha- silencing suppressor proteins.- Role of vec- ogy; Food Science rides.- Oligosaccharides.- Complex Polysaccharides.- tor transmission proteins.- In vivo analysis Glycolipids.- Glycoproteins.- Glycomimetics.- Key of Viral RNA translation.- In vitro analysis Target groups Technologies and Tools for Functional Glycobiolo- of translational enhancer.- Identification of Chemists, biochemists, pharmacists, and medical re- gy.- Biosynthesis and Degradation.- Glycomedicine. plant virus IRES.- Analysis of geminivirus searchers in pharmaceutical and chemical industry; researchers and engineers in food technology and DNA replication by 2-D gel.- Begomoviruses: Fields of interest agrobusiness; researchers in organic, medicinal and Molecular cloning and identification of replication Organic Chemistry; Biochemistry, general; Molecu- biochemistry, and in molecular medicine origin.- Analysis of viroid [..] lar Medicine; Biotechnology; Pharmacology/Toxicol- ogy; Food Science Fields of interest Type of publication Handbook Plant Sciences; Virology; Plant Genetics & Genomics Target groups Chemists, biochemists, pharmacists, and medical re- Target groups Due March 2008 searchers in pharmaceutical and chemical industry; Plant scientists, plant virologists, plant pathologists, researchers and engineers in food technology and plant biotechnologists, plant breeders, virologists, agrobusiness; researchers in organic, medicinal and and plant geneticists 2008. eReference. biochemistry and in molecular medicine 999,00 € Type of publication ISBN 978-3-540-30429-6 Type of publication Contributed volume Handbook

Due May 2008 Due March 2008

2008. 816 p. 62 illus., 1 in color. (Methods in Molecular Biology, 2008. Approx. 3000 p. (in 3 volumes, not available separately). Vol. 451) Hardcover Hardcover 74,95 € 999,00 € ISBN 978-1-58829-827-0 ISBN 978-3-540-36154-1 42 Life Science springer.com/booksellers

L.A. Freeman, National Institutes of Health, Bethesda, MD. USA A. Friedman, Ohio State University, OH, USA (Ed.) O. Fränzle, L. Kappen, H.-P. Blume, K. Dierssen (Eds.) (Ed.) Tutorials in Mathematical Ecosystem Organization of a Lipoproteins Biosciences IV Complex Landscape

Evolution and Ecology Long-term Research in the Bornhöved Lake District, Germany

Fields of interest Molecular Medicine; Biochemistry, general; Human The book offers an easy introduction to fast grow- This volume provides a synthesis of long-term eco- Genetics; Bioinformatics ing research areas in evolution of species, popula- logical analyses in the Bornhöved Lake District as tion genetics, ecological models, and population dy- a representative landscape of northem Germany. Target groups namics. The first two chapters review the concept The emphasis is on the comprehensive assessment Molecular biologists and biochemists, bioinformati- and methodologies of phylogenetic trees; computa- of matter and energy fluxes in and between the ter- cians, and genetics researchers tional schemes and illustrations are given, including restrial and aquatic ecosystems and their biocoenot- Type of publication applications such as tracing the origin of SARS and ic structures and dynamics on the one hand, and Contributed volume influenza. The third chapter introduces the reader on transdisciplinary landscape planning approach- to ecological models, including predator-prey modes on the other. In each respect the development of els. This chapter includes an introduction to reac- novel hierarchical modelling approaches at various Due September 2009 tion-diffusion equations, which are used to analyze spatial and temporal scales is fundamental to the the ecological models. The next chapter reviews a understanding of the structure and function of sys- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary broad range of ongoing research in population dy- tems and to integrative resource management strate- entry 2252) Hardcover namics, including evolution of dispersal models; it gies. Thus, the book is not only commendable for also features interesting mathematical theorems and ecologists, but is equally useful for botanists, zoolo- 76,65 € lists open problems. The final chapter deals with gists, geographers, landscape planners, soil scientists, ISBN 978-1-60327-368-8 gene frequencies under the action of migration and agronomers, hydrologists, climatologists and other selection. The book is addressed to readers at the scientists interested in energy balances or the quality level of graduate students and researchers. A back- and quantity of waterflows and nutrient cycles, and ground in PDEs is provided. managers looking for relevant case studies and [..]

Contents Features Inference of Phylogenetic Trees (Laura Salter Ku- Analyses the fundamental processes of energy, water batko).- Large-Scale Phylogenetic Analysis of Emerg- and nutrient cycling in order to improve both inte- ing Infectious Diseases (Daniel Janies and Diego gral landscape planning and resource management Pol).- Reaction-Diffusion Equations and Ecological techniques. Modeling (Chris Cosner).- The Dynamics of Migra- tion-Selection Models (Thomas Nagylaki and Yuan Contents Lou).- Some Challenging Mathematical Problems General Concept of the Research Programme and in Evolution of Dispersal and Population Dynamics Methodology of Investigations.- Ecological Setting (Yuan Lou). of the Study Area.- Ecophysiological Key Process- es in Agricultural and Forest Ecosystems.- Carbon Fields of interest and Energy Balances of Different Ecosystems and Mathematical Biology in General; Physiological, Cel- Ecosystem Complexes of the Bornhöved Lake Dis- lular and Medical Topics trict.- Water Relations at Different Scales.- Site-Re- lated Biocoenotic Dynamics.- Biocoenotic Interac- Target groups tions between Different Ecotopes.- Element Fluxes Researchers and graduate students in mathematics in Atmosphere, Vegetation and Soil.- Transport Pro- and/or biology interested in mathematical modeling cesses between Lake Belau and its Drainage Basin.- of biological processes Lake Belau.- Ecological Gradients as Causes and [..]

Type of publication Fields of interest Monograph Landscape Ecology; Ecosystems; Environmental Management; Limnology; Terrestial Ecology; Sus- Due October 2007 tainable Development

Target groups 2008. VII, 205 p. 21 illus. (Mathematical Biosciences Subseries, Researchers, landscape planners, environmental Vol. 1922) Softcover managers, and advanced students 39,95 € Type of publication ISBN 978-3-540-74328-6 Contributed volume

Due February 2008

2008. Approx. 400 p. 155 illus. (Ecological Studies, Vol. 202) Hard- cover

139,95 € ISBN 978-3-540-75810-5 springer.com/booksellers Life Science 43

T. Furuichi, Meiji-Gakuin University, Totsuka, Yokohama, Japan; S.C. Gad K.A. Galvin, Colorado State University, Fort Collins, USA; R.S. Reid, J. Thompson, Lukuru Wildlife Research Project, Kinshasa, Demo- International Livestock Research Institute, Nairobi, Kenya; R.H. cratic Republic of Congo (Eds.) Behnke, Jr., Macaulay Land Use Research Institute, Aberdeen, Bayesian Analysis in Scotland, UK; N.T. Hobbs, Colorado State University, Fort Collins, USA (Eds.) The Bonobos Pharmaceutical Development and Clinical Research Biology, Behavior, and Conservation Fragmentation in Semi-Arid and Arid Landscapes

Consequences for Human and Natural Systems Among all great ape species, the bonobo is still the Fields of interest least studied in both captivity and the wild. Never- Statistics for Life Sciences, Medicine, Health Sciences theless we have observed a considerable increase in knowledge across various fields of bonobo research Type of publication The global significance of the world’s rangelands is in recent years. In part due to the ongoing peace pro- Contributed volume large, with these arid and semi-arid systems mak- cess in the Democratic Republic of Congo, research ing up almost 25% of the earth’s landscapes – and and conservation activities on the bonobo have re- Due March 2009 supporting the livelihoods of more than 20 million sumed and multiplied since 2001. Part One of The people. These ecosystems are also home to several Bonobos: Behavior, Ecology, and Conservation fo- of the planet’s remaining megafauna, as well as oth- cuses on scientific research. Behavioral studies in 2007. Hardcover er important species. Yet fragmentation across these captivity propose to answer why bonobos have some rangelands has significantly impaired the ability of 99,95 € unique characteristics such as high social status of fe- both people and animals to compensate for tempo- ISBN 978-1-58829-726-6 males and flexible social relationships. The outcomes ral heterogeneity in vegetation and water by exploit- present important aspects to be investigated in run- ing its spatial heterogeneity, resulting in limited re- ning field studies. In the wild, analysis of popula- source availability. The case is developed that while tion genetics across the bonobo's distribution range fragmentation arises from different natural, social illuminates the species' evolutionary path and con- and economic conditions worldwide it creates simi- tributes to a global management plan. Site specific lar outcomes for human and natural systems. With analysis reveals how genetics are used to re-identify information from nine sites around the world the au- individuals after an extended [..] thors examine how fragmentation occurs, the patterns that result, and the consequences of fragmenta- Features tion for ecosystems and the people who depend on Consists of two parts which intend to integrate both them. new scientific insights from captive and wild investigations and the most recent achievements in conser- Features vation First book to show how fragmentation of natural systems influences human welfare, economies Unique Contents in global coverage, integration of social, natural sci- Introduction.- Behavioral Study Section.- The ences of fragmentation in rangelands Complex sys- Bonobo's Adaptive Potential: Social Relations under tems are self sustaining, whereas simplified ones of- Captive Conditions.- What Does Agonistic Domi- ten want capital inputs, subsidies Shows linkage of nance Imply in Bonobos?.- Social Play in Bonobos: multiple scale analyses Rangeland use exclusivity Not Only an Immature Matter.- Gestures and Multi- does not promote human welfare or sustain natural modal Signaling in Bonobos.- Ecological Study Sec- processes tion.- Foreword.- Longitudinal Structure of a Unit- group of Bonobos: Male Philopatry and Possible Fu- Contents sion of Unit-groups.- Seasonal Changes in Fruit Pro- 1. Global significance of extensive grazing lands and duction and Party Size of Bonobos at Wamba.- Re- pastoral societies. 2. Fragmentation of arid and se- lationships among Fruit Abundance, Ranging Rate, mi-arid ecosystems. 3. Causes and consequences of Party Size and Composition of Bonobos at Wamba.- herbivore movement in landscape ecosystems. 4. Bonobo [..] Changing patterns of land use and tenure in the Dal- rymple Shire, Australia. 5. From fragmentation to Fields of interest reaggregation of rangelands in the Northern Great Animal Ecology; Developmental Biology; Zoology Plains. 6. Land use, fragmentation, and impacts on wildlife in Jackson Valley, Wyoming. 7. Ideology, Target groups land tenure and livestock mobility in Kazakhstan. 8. Researchers, scientists, professionals, and graduate Policy changes in Mongolia. 9. Fragmentation of a students in the fields of Primatology, Physical An- peri-urban savanna, Athi-Kaputiei [..] thropology, Zoology and Animal Behavior Fields of interest Type of publication Ecosystems; Anthropology; Ecology; Geography; Contributed volume Biodiversity

Due January 2008 Target groups Ecologists and social scientists interested in the 2008. Approx. 280 p. (Developments in Primatology: Progress world’s rangelands and pastoral economies, scien- and Prospects) Hardcover tists, academics, students, development practitioners, readers of the journal Human Ecology and the Jour- 114,95 € nal of Arid Lands ISBN 978-0-387-74785-9 Type of publication Contributed volume

Due October 2007

2008. xviii, 411p. Hardcover 44 Life Science springer.com/booksellers

159,95 € G. Garrity, Michigan State University, East Lansing, MI, USA (Ed.) C. Gaultier, Robert Debre Hospital, Paris, France (Ed.) ISBN 978-1-4020-4905-7 Bergey's Manual of Systematic Genetic Basis for Respiratory Bacteriology Control Disorders

Volume 3: The Low G + C Gram Positives

This book provides an overview of the recent advances in the genetics of respiratory control in health Bergey's Manual of Systematic Bacteriology, one of and disease. The objective of the book is to bring to- the most comprehensive and authoritative works in gether top-level contributions on all aspects of the the field of bacterial taxonomy, has been extensive- genetics of respiratory control. These include molec- ly revised in the form of a five volume Second Edi- ular aspects of respiratory neurodevelopment from tion. Since the first edition was published in 1984, embryonic to postnatal life, molecular biology of hu- the field has undergone explosive growth, with over man respiratory control disorders, and interactions 2,200 new species and 390 new genera having been between genetics and plasticity in respiratory con- described. This new edition has been completely re- trol. The book will also show how combined stud- organized along phylogenetic lines to reflect the cur- ies in humans and mouse models have helped to im- rent state of prokaryotic taxonomy but still main- prove our understanding of the mechanisms that un- tains the familiar layout of the First Edition. In addi- derlie genetically determined respiratory control dis- tion to the detailed treatments, provided for all of the orders with the goal of developing new therapeutic validly named and well-known species of prokary- interventions. otes, new ecological information and more extensive introductory chapters have been added. Use of the Features manual is aided by a system of cross referencing be- First to provide an overview of recent advances in tween the phylogenetic groups and the phenotypic the genetics of respiratory control in health and dis- groups used in the First Edition. ease

Contents Fields of interest 1= description of any changes to the "road-map to Neurobiology; Human Genetics; Pneumology/Respi- the taxa" will beincluded, if required. Contents will ratory System; Pediatrics; Neurosciences; Thoracic be updated as we approachpublication. Surgery

Fields of interest Target groups Life Sciences, general; Biomedicine general Respiratory physiologists, neurobiologists, geneticists Target groups Bacteriologists Type of publication Contributed volume Type of publication Reference work Due November 2007 Due December 2007 2008. Approx. 400 p. 170 illus., 16 in color. Hardcover

Originally published by Williams & Wilkins, 1984 114,95 € ISBN 978-0-387-70764-8 2008. Approx. 1330 pp. 393 illus. Hardcover

153,25 € ISBN 978-0-387-95041-9 springer.com/booksellers Life Science 45

E.F. George, Westbury, UK; M.A. Hall, Institute of Biological Sci- G.A. Gerencser, University of Florida Medical School, Gainesville, C. Gerner, Institute of Cancer Research, Vienna, Austria (Ed.) ences, Aberystwyth, Wales, UK; G.-J. De Klerk, Plant Research In- FL, USA (Ed.) ternational, Wageningen, The Netherlands (Eds.) Gel-Based Proteome Analysis Epithelial Transport Physiology Plant Propagation by Tissue Culture Techniques

Volume 1. The Background The scope of this book was preempted and precip- itated by the pioneering studies of Ussing and co- Fields of interest workers. The first phase of the phenomenological de- The first edition of “Plant Propagation by Tissue Proteomics; Cell Biology; Microbiology; Plant Sci- scription of the cell as a black box has been followed Culture” by Edwin F. George appeared in 1986. A ences by studies of cellular mechanisms, the interplay of second edition consisting of two volumes appeared the different transport components, and the mecha- in 1993 and 1996. For researchers and students, Type of publication nisms of regulation which will be covered in the in- George’s books have become the standard works on Contributed volume dividual chapters. For the individual epithelia trans- in vitro plant propagation. The volumes also contain port schemes that have been proposed, I think it is a wealth of information for researchers and com- Due February 2009 appropriate to take pause and search for elements panies working in related areas; particularly plant common to several epithelia. This aspect triggered breeding, genetic engineering, phytopathology, pro- the common theme idea for this book, and in fact the 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary duction of secondary metabolites and conservation. various chapters emphasize that the functional trans- entry 2220) Hardcover Scientific knowledge has expanded rapidly since the porter components, expressed in the various epithe- second edition and it would now be a daunting task 76,65 € lia, are not infinite in number, but they occur in ep- for a single author to cover all aspects adequately. ISBN 978-1-60327-199-8 ithelia which are separated in evolution by several Therefore, in this third edition, topics are being cov- hundred million years. ered by a number of specialists. However, this edition still maintains the integration that was charac- Contents teristic of the previous editions. The first volume of Active, electrogenic chloride absorption in inver- the new edition highlights the scientific background tebrate foregut.- Sulfate transport in lobster hep- of in vitro propagation. The second volume, which is atopancreas.- Heavy metal transport in lobster lyso- in preparation, will cover the practice of [..] somes.- H+-ATPase and K+ /H + antiporter constitute a K+ pump in lepidopteran midgut.- Genomic Features regulation of amino acid transport.- CFTR, a trans- Provides an encyclopaedic coverage of plant tis- porter in health and disease.- Chloride transport sue culture and its applications Plant tissue culture, in the vertebrate intestine.- Sulfate and phosphate the topic of the book, is one of the pillars of plant transport in intestinal and renal epithelia.- Amino biotechnology Merges applied aspects and basic sci- acid transporters in mammalian epithelia.- Sugar ence Both for people new in the field and experi- transport in vertebrate epithelia.- Renal acid/base enced researchers regulation via ammonia transport in [..] Contents Fields of interest Biographical Notes on Contributors.- 1.Plant Tis- Animal Physiology; Biochemistry, general; Cell Biol- sue Culture Procedure- Background.- 2.Microprop- ogy agation: Uses and Methods.- 3.The Components Of Plant Tissue Culture Media I : Macro- and Micronu- Target groups trients.- 4.The Components Of Plant Tissue Culture Physiologists, pharmacologists, cell biologists, bio- Media II : Organic supplements, Organic Acids, Os- chemists motic and pH Effects and Support systems.- 5.Plant Growth Regulators: Introduction I: Auxins, Their Type of publication Analogues And Inhibitors.- 6.Plant Growth Regu- Contributed volume lators II: Cytokinins, Their Analogues And Antago- nists.- 7.Plant Growth Regulators III: Gibberellins, Due October 2008 Ethylene, Abscisic Acid, Their Analogues And [..]

Fields of interest 2008. Approx. 320 p. Hardcover Plant Sciences; Agriculture; Plant Physiology; Plant Anatomy/Development; Cell Biology 127,05 € ISBN 978-1-60327-228-5 Target groups Degree students in horticulture and plant physiology, researchers at universities, institutes and companies, libraries of universities, institutes and companies

Type of publication Graduate/advanced undergraduate textbook

Due October 2007

2007. Approx. 500 p. Hardcover

194,95 € ISBN 978-1-4020-5004-6 46 Life Science springer.com/booksellers

M. Goitein, Windisch, Switzerland L. Gomes, Zoology Department, UNESP-Rio Claro, Brazil (Ed.) I.J. Gordon, CSIRO, Townsville, QLD, Australia; H.H.T. Prins, Wa- geningen University, The Netherlands (Eds.) Radiation Oncology: A Physicist's- Forensic Entomology: New Trends Eye View and Technologies The Ecology of Browsing and Grazing Insects and Death

Radiation Oncology: A Physicist's-Eye View was written for both physicists and Extensive grazing and browsing by domestic and This book provides the current entomological tech- medical oncologists with the aim of helping them wild herbivores shape the vegetation composition, niques and procedures essential for crime and death approach the use of radiation in the treatment structure and dynamics of many terrestrial ecosys- scene investigations. This includes detailed discus- of cancer with understanding, confidence, and tems. This volume investigates how large herbivores sions of decomposition analysis, as well as the collec- imagination. The book will let practitioners in not only influence the structure and distribution of tion, preservation, and identification of insects and one field understand the problems of, and find solu- the vegetation, but also affect nutrient flows and the arthropod relatives. Complete chapters illustrate the tions for, practitioners in the other. It will help them responses of associated fauna. The mechanisms and role of Diptera and Coleoptera in investigations and to know "why" certain approaches are fruitful while, processes underlying the herbivores' behaviour, dis- features keys for immature insect identification, the at the same time, encouraging them to ask the ques- tribution, movement and direct impact on the vege- behaviour of post-feeding larval dispersal, and crit- tion "Why not?" in the face of assertions that some tation, and the dynamics of nutrients, plant species, ical information for post mortem interval determi- proposal of theirs is impractical, unreasonable, or and vegetation composition in terrestrial ecosystems nation. Laboratory-based subjects include entomo- impossible. Unlike a textbook, formal and complete are discussed in detail. It is shown that an under- toxicology, molecular techniques, DNA sequencing, developments of the topics are not among the standing of plant/animal interactions can provide and spatial modelling for the prediction of insect be- goals. Instead, the reader will develop a foun- practical advice on the management of large herbi- haviour. Specialty subjects not covered anywhere else dation for understanding what the author has found vores to integrate production and conservation in deal with the insect nervous system, insects of foren- to be matters of importance in radiation on- terrestrial systems, particularly in the face of envi- sic importance other than flies and beetles, indoor cology during over thirty years of experience. Pre- ronmental and climate change. arthropods, phoretic mites, and insects in cases of sentations cover, in largely non-technical language, neglect of children and the elderly. A history of death the principal physical and biological aspects of radia- Features and surrounding myths help illustrate the roots of tion [..] Shows how large herbivores react to the changes of forensic entomology. [..] their environment Provides also practical advice on Features the management of large herbivores Features Shares the viewpoint of a person standing with one Offers contributions from some of the best foot in physics and the other in radiation oncolo- Contents and most famous researchers in forensic entomol- gy Designed to assist practitioners in physics under- Grazers and Browsers in a Changing World: In- ogy Discusses the application of new technologies stand the problems of, and find solutions for, practi- troduction.- An Evolutionary History of Browsing in solving crimes using the study of insects tioners in radiation oncology and vice versa Written and Grazing Ungulates.- The Morphophysiolog- in corpses Introduces research not previously re- by an international expert in proton, light ion, and ical Adaptations of Browsing and Grazing Mam- ported Contains 100 pages on general entomolo- heavy charged particle radiotherapy mals.- Nutritional Ecology of Grazing and Browsing gy, making the subject understandable for all Ruminants.- The Comparative Feeding Bahaviour Contents levels interested in this field of Browsing and Grazing Large Herbivores.- The Assessment of Uncertainties; Use of Imaging to De- Comparative Population Dynamics of Browsing and Fields of interest fine Anatomy; Overview of the Physics of the Inter- Grazing Ungulates.- Species Diversity of Browsing Invertebrates; Zoology; Criminology & Criminal Jus- actions of Radiation With Matter; Biophysical Mod- and Grazing Ungulates: Consequences for the Struc- tice; Life Sciences, general els of Radiation Damage; Definition of the Goals of ture and Abundance of Secondary Production.- Im- pacts of Grazing and Browsing by Large Herbivores Radiation Therapy; Design of Radiation Therapy Ap- Target groups on Soils and Soil [..] proaches; Management of Patient and Organ Mo- Forensic scientists, graduate and undergraduate stu- tion; Computer-based Optimization of Treatments; dents. and Proton Therapy. Fields of interest Ecology; Vertebrates; Forestry; Agriculture; Environ- Type of publication mental Management; Plant Sciences Fields of interest Graduate/advanced undergraduate textbook Biophysics; Biomedical Engineering; Cancer Re- search Target groups Due October 2007 Researchers, environmental managers, and advanced Target groups students Biophysicists, researchers, radiation oncologists 2008. Approx. 610 p. Hardcover Type of publication Type of publication 89,95 € Contributed volume Monograph ISBN 978-1-4020-6139-4 Due October 2007 Due November 2007 2007. XV, 328 p. 34 illus. (Ecological Studies, Vol. 195) Hardcover 2007. Approx. 305 p. (Biological and Medical Physics, Biomedical Engineering) Hardcover 119,95 € ISBN 978-3-540-72421-6 99,95 € ISBN 978-0-387-72644-1 springer.com/booksellers Life Science 47

I.M. Gould, Aberdeen Royal Infirmary, Aberdeen, UK; J.W.M.v.d. J. Gould, USDA-APHIS, MA, USA; K. Hoelmer, USDA-ARS, Newark, G. Govil, Tata Institute of Fundamental Research, Mumbai, India; Meer, University Hospital Nijmegen, The Netherlands (Eds.) DE, USA; J. Goolsby, USDA-ARS, Waslaco, TX, USA (Eds.) K.V.R. Chary, Tata Institute of Fundamental Research, Mumbai, India Antibiotic Policies: Fighting Classical Biological Control of Resistance Bemisia tabaci in the United States NMR in Biological Systems From Molecules to Human

This volume continues the tradition of the editors' first volume, Antibiotic Policies: Theory and Fields of interest During teaching NMR to students and researchers, Practice, by assembling contributions from experts Invertebrates; Plant Pathology; Agriculture we felt the need for a text-book which can cover around the world concerned with responsible antibi- modern trends in the application of NMR to bio- otic resistance and fighting resistance. This volume Target groups logical systems. This book caters to the needs of: (i) looks at many of the crucial issues of resistance in a Agricultural research scientists, extension specialists, graduate students who mostly learn such techniques clinical context, with an emphasis on MRSA; sure- biological control and pest management practition- from senior post-docs in the laboratory; (ii) those ly the greatest challenge to our antibiotic and infec- ers, federal and state regulatory agencies (both in the who are not experts in NMR but wish to understand tion control policies that modern health care systems United States and abroad). if a particular problem in animal, plant, medical and have ever seen. Other fascinating chapters explore pharmaceutical sciences can be answered by NMR; Type of publication the psychology of prescribing, modern management and (iii) those who are experts in chemistry and bio- Contributed volume techniques as an adjunct to antibiotic policies, and chemistry and wish to know how NMR can provide the less obvious downsides of antibiotic use. Last- them information on structural or functional aspect ly, several chapters from authors living in Mediter- Due November 2007 of proteins, nucleic acids, cells and tissues, human ranean countries give a perspective from an area of and plant organs and other biological materials. This the world with some of the greatest problems in an- 2008. Approx. 300 p. (Progress in Biological Control, Vol. 4) Hard- book builds a means of knowledge transfer between tibiotic use and resistance. cover the beginners and the experts in NMR as applied to all aspects of life sciences. Features 149,95 € Complete reference to antibiotics, encompassing all ISBN 978-1-4020-6739-6 Features aspects of policy, theory, and resistance Editors are Covers entire area of NMR in Biological Sciences well-known and highly respected in the international (Biomolecules, cells and tissues, animals, plants and infectious diseases community drug design) Most of the NMR books focus on one or two of the topics covered in the book Excellent Contents book for teaching a course on NMR in Biological Consequences of antimicrobial chemotherapy: over- Systems growth, resistance and virulence.- The process of antibiotic prescribing, can it be changed?- Cultural and Contents Socio-Economic Determinants of Antibiotic Use.- Preface.- Acknowledgements.- Foreword.- Abbre- Electronic prescribing.- Prevalence surveys of an- viations.- Basic Concepts in NMR Spectroscopy.- timicrobial use in hospitals; purpose, practicalities Introduction to Biological NMR.- Multi-Dimen- and pitfalls.- Antibiotic Use in Hospitals in the Unit- sional NMR.- Biomolecular Structures using NMR: ed States SCOPE-MMIT Antimicrobial Surveillance General Principles.- Protein NMR: General Princi- Network.- New Hospital Initiatives in Fighting Re- ples and Resonance Assignments.- Structure, Dy- sistance.- Antimicrobial Resistance: Preventable or namics and Function of Proteins.- Structure and Inevitable? Problem of the Era from Two Perspec- Dynamics of Nucleic Acids.- Carbohydrates, Lipids tives.- Fighting antimicrobial [..] and Lipid Assemblies.- High-Resolution Solid-State NMR.- Biomolecular intermolecular interaction and Fields of interest Supramolecular Assemblies.- Magnetic Resonance Immunology; Microbiology; Infectious Diseases; Vi- Imaging.- Study of Metabolism: Cells and Tissues.- rology; Pharmacology/Toxicology MRS Studies of [..]

Target groups Fields of interest Researchers, scientists, professionals, clinicians, Biotechnology; Physical Chemistry; Imaging / Radi- physicians, and graduate students in the fields of Im- ology; Life Sciences, general; Biochemistry, general; munology, Microbiology, Infectious Disease, Virolo- Biophysics gy, Pharmacology and Toxicology, and Medicine Target groups Type of publication Graduate level students (M.S.) as a graduate course, Contributed volume Researchers who wish to understand if a particular problem they have in medical and pharmaceuti- Due October 2007 cal sciences would be answered by NMR, but have no intention to become professional NMR spectro- scopists, Researchers who are experts in biochem- 2007. XIV, 286 p. 29 illus., 10 in color. Hardcover istry and yet do not know how NMR can help to pro- 114,95 € vide them information on structural or functional as- ISBN 978-0-387-70840-9 pects of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials

Type of publication Undergraduate textbook

Due December 2007

2008. Approx. 510 p. (Focus on Structural Biology, Vol. 6) Hard- cover

94,95 € 48 Life Science springer.com/booksellers

ISBN 978-1-4020-6679-5 I. Gozes, Sackler School of Medicine, Tel Aviv University, Tel Aviv, B. Green, G. Begg, G. Carlos, B. Mapstone (Eds.) Israel (Ed.) Gathering Information from Neuropeptide Techniques Otoliths of Tropical Fishes

Neuropeptides are very small proteins that are released by nerve cells to influence neighboring cells Fields of interest and tissues. Neuropeptides exhibit multiple func- Animal Anatomy / Morphology / Histology tions as hormones and regulators. As such, many techniques are required to understand the contri- Type of publication bution and functions of these important messenger Contributed volume molecules in health and disease processes. Research in the neuropeptide field is aimed toward a better Due September 2008 understanding of the physiology of the human body and toward the development of better diagnostics and therapeutics. This books contents will familiarize 2008. Hardcover the audience with forefront techniques in the field. 145,00 € Features ISBN 978-1-4020-3582-1 A selected description of techniques in neuropeptide research written by leaders in the field Design synthesis and biological evaluation of peptides and peptide analogues Emphasis to advanced technologies of transfection transgenic delivery and bioinformatics Primary cells and cell lines techniques in neuropeptide processing trafficking and secretion In vivo techniques quantifying blood-brain barrier [..]

Contents The Design, Synthesis and Biological Evaluation of Peptide Analogs: VIP as an Example.- Antibody Pro- duction: Activity-Dependent Neuroprotective Pro- tein (ADNP) as an Example.- Primary Cell Cultures and Cell Lines.- Transfection of DNA into Cells.- Transgenic Delivery and Detection of GFP in Neu- ropeptide Neurons.- Integrative Technologies for Neuropeptide Characterization.- Techniques in Neu- ropeptide Processing, Trafficking and Secretion.- In Vivo Techniques Quantifying Blood-Brain Barrier Permeability to Small Proteins in Mice.- Cancer Cell Receptor Internalization and Proliferation: [..]

Fields of interest Neurosciences; Proteomics; Human Physiology; Neurobiology

Target groups Neuroscientists, undergraduates and graduate students in Neuroscience, neuropeptitde researchers, bioinformatic researchers, Pharmaceutical researchers, molecular and cell biologists

Type of publication Contributed volume

Due November 2007

2007. Approx. 161 p. 51 illus. 1 in color (Neuromethods, Vol. 39) Hardcover

99,95 € ISBN 978-1-58829-468-5 springer.com/booksellers Life Science 49

E. Grotewold, The Ohio State University, Columbus, OH, USA (Ed.) J.P. Gustafson, University of Missouri, Columbia, Missouri (Ed.) J. Habu, University of California at Berkeley,CA, USA; C. Fawcett, Saint Francis Xavier University, Antigonish, Nova Scotia, Cana- da; J.M. Matsunaga, University of California at Berkeley,CA, USA The Science of Flavonoids Genomics of Disease (Eds.)

Evaluating Multiple Narratives Despite the historical signifigance of flavonoids and The title will develop from the 24th Stadler sympo- their pigments in establishing the basis for modern sium. It will explore the general theme "GENOME Beyond Nationalist, Colonialist, Imperialist Archaeologies genetics, research in this large group of secondary EXPLOITATION: Data Mining the Genomes". The metabolites continues to be more intense than ev- idea behind the theme is to discuss and illustrate how er. While research has focused in the past primari- scientists are going to characterize and make use of At the end of the 20th Century, archaeologists from ly on the chemistry and biosynthesis of flavonoids, the massive amount of information being accumu- non-Anglo-American countries started to become the past few years have witnessed increasing research lated about plant and animal genomes. The book vocal about the "traditional" interpretations of his- in the applications of flavonoids as nutraceuticals will present a state-of-the-art picture on mining the tory that archaeology was making. The "traditional" and pharmaceuticals as well as on their roles as sig- Genome databases. This will be one of the few times archaeology came from the predominantly white, nal molecules within plants and between plants and that researchers in both plants and animals will be male archaeologists from England and the United other organisms. No book has tried to provide a working together to create a seminal data resource. States going to other countries and interpreting the comprehensive overview of the flavonoid field since material culture from their point of view. This, of 1990. This book will comprehensively cover the Features course, is still happening but is becoming less accept- emerging areas in the field of flavonoid research and Comprehensive coverage of current topics Chapters able nor accepted by the global world of archaeology. their applications. First, flavonoids must be intro- authored by key stars in the field Accessible utility in The goal of this volume is to use archaeological case duced as chemical entities and then an overview of a single volume reference studies from around the world to evaluate the impli- the tools currently available for their analysis will be cations of providing alternative interpretations of the Contents presented. past. These cases also address key questions such as: Signaling networks in plant defense.- Genetic Map- Can multivocality (multiple interpretations of the ping of Complex.- Genomics of the rice defense sig- Features past) be separate from the theory of contemporary naling pathway.- Genetic interactions that medi- The only book of its kind to provide an overview of Anglo-American archaeology; is multivocality rele- ate autoimmune disease.- Extracting meaning from the science of flavonoids in plants vant to local residents and non-Anglo-American ar- high-dimensional 'omics data.- Unraveling the ge- chaeologists; and can the close examination of alter- Contents netic mysteries of the Cat: New discoveries in feline native interpretations contribute to [..] Preface.- The Stereochemistry of Flavonoids.- Meth- inherited diseases and traits.- Variation in chicken ods in Flavonoid Isolation and Identification.- The gene structure and expression associated with food- Features Biosynthesis of Flavonoids.- Transcriptional Reg- safety pathogen resistance.- Functional Genomics This volume brings together international cases to ulation of Flavonoid Biosynthetic Genes.- Trans- and Bioinformatics of the Soybean-Phytophthora In- discuss multivocality in archaeology The editors all port of Flavonoids.- Flavonoid Pigments as Tools in teraction.- The genetics governing merle coat pat- have experience working in Anglo-American and Molecular Genetics.- The Evolution of Flavonoids terning in the domestic dog and association [..] underrepresented areas of the world and can edit a and Their Genes.- Flavonoids as Nutraceuticals.- book on multivocality with authority Flavonoid as Signal Molecules.- Index. Fields of interest Human Genetics; Plant Genetics & Genomics; Ani- Contents Fields of interest mal Genetics and Genomics Introduction.- Part I. Operationalizing Multivocali- Plant Biochemistry; Plant Sciences; Plant Physiology; ty.- Introduction to Part I.- An Ethical Epistemology Target groups Plant Genetics & Genomics of Publicly Engaged Biocultural Research: Archaeol- biomedical academics, scientists, and industry pro- ogy of the New York African Burial Ground.- Multi- Target groups fessionals in bioinformatics, genetics, genomics, life ple Voices for Many Ears in Indigenous Archaeolog- Researchers, institutes, professors and industry, food sciences: plant, animal geneticists ical Practice.- “Making a Home”: Archaeologies of science and nutrition researchers Type of publication the Medieval English Village.- Critical Histories of Type of publication Contributed volume Archaeological Practice: Latin American and North Contributed volume American Interpretations in a Honduran Context.- Part Ii. Evaluating Multiple Narratives In Various Due January 2008 Regional And Historical Settings.- Introduction to Due December 2007 Part II .- Science or Narrative? [..] 2008. Approx. 245 p. Hardcover 2008. Approx. 280 p. Softcover Fields of interest 99,95 € Archaeology; Anthropology 69,95 € ISBN 978-0-387-76722-2 ISBN 978-0-387-74550-3 Target groups Archaeologists both academic and professional, social anthropologists and historians

Type of publication Contributed volume

Due December 2007

2007. Approx. 280 p. Hardcover

46,95 € ISBN 978-0-387-71824-8 50 Life Science springer.com/booksellers

K. Hackländer, University of Natural Resources and Applied Life J. Haffer, Essen, Germany H. Haken, University of Stuttgart, Germany Sciences, Vienna, Austria; P.C. Alves, University of Porto, Portugal; N. Ferrand, University of Porto, Portugal (Eds.) Ornithology, Evolution, and Brain Dynamics

Lagomorph Biology Philosophy An Introduction to Models and Simulations

Evolution, Ecology, and Conservation The Life and Science of Ernst Mayr 1904-2005

Brain Dynamics is an introduction for graduate students and nonspecialists from various backgrounds This book is the first detailed biography of Ernst Lagomorphs are a mammalian order which in- to the field of mathematical and computational neu- Mayr. He was an ‘architect’ of the Synthetic Theo- cludes rabbits, hares and pikas. They are distribut- rosciences. The approach in this book is through ry of Evolution, and the greatest evolutionary biolo- ed throughout the world and are of both scientific pulsed-coupled neural networks, with at their core gist since Charles Darwin, influential historian and and public interest as they are classified between en- the lighthouse and integrate-and-fire models, which philosopher of biology, outstanding taxonomist and dangered and pest species. In addition, some have allow for the highly flexible modelling of realistic ornithologist, and naturalist. He is one of the most a high economic value as important game species. synaptic activity, synchronization and spatio-tem- widely known biologists of the 20th century. Mayr In the last few decades, a huge amount of informa- poral pattern formation. As a more advanced top- used the theories of natural selection and population was made available to the scientific community ic, pulse-averaged equations and their application tion thinking as theoretical models within the frame- and resulted in remarkable advances on all aspects to movement coordination are discussed. The book work of historical biological studies. He suggested of Lagomorph biology. However, this information closes with a short analysis of models versus the re- that various competing paradigms may exist side by is dispersed in multiple scientific and non-scientific al neurophysiological system. The second edition side and more or less pronounced ’revolutions’ may journals. This book provides an updated synthesis of has been thoroughly updated and augmented by an occur in different fields from time to time. Changes the current knowledge on Lagomorph biology. extensive chapter that discusses the interplay be- of concepts have a much stronger effect on the devel- tween pattern recognition and synchronization. Fur- Features opment of biological sciences than the discovery of ther, to enhance the usefulness as textbook and for First book to cover all aspects of lagomorph biology new facts. Mayr was the first to emphasize the role of self-study, the detailed solutions of all XX exercises biopopulations, thereby pointing out the basic differ- throughout the text have been added. Contents ence between ’population thinking’ and typological Introduction to the Lagomorpha.- Palaeontology and essentialism. Population thinking takes into consid- Contents Evolution. Prehistoric and historic artificial disper- eration the uniqueness of each [..] From the contents Basic Experimental Facts and sal of lagomorphs on the Mediterranean islands. The Theoretical Tools.- Introduction.- The Neu- Lagomorph fossil record and the origin of the Eu- Features ron-Building Block of the Brain.- Neuronal Coop- ropean rabbit. Inferring the evolutionary history of Biography of one of the greatest biologists of the 20th erativity.- Spikes, Phases, Noise: How to Describe the European rabbit (Oryctolagus cuniculus) from century them Mathematically? We Learn a Few Tricks and molecular markers. Phylogenetic aspects of nuclear Some Important Concepts.- Spiking in Neural Nets.- and mitochondrial gene-pool characteristics of South Contents The Lighthouse Model. Two Coupled Neurons.- The and North African cape hares (Lepus capensis) and The young naturalist in Germany. Childhood and Lighthouse Model. Many Coupled Neurons.- Inte- European brown hares (L. europaeus).- Population youth. The budding scientist.- Ornithologist in New grate and Fire Models (IFM).- Many Neurons, Gen- Ecology and Dynamics. The world of pikas. When? York. The New York years (1931 – 1953). Ornitholo- eral Case, Connection with Integrate and Fire Mod- Where? And for how long? Census [..] gist and zoogeographer. Biological species and speci- ation – Mayr’s first synthesis. Life in New York dur- el.- Phase Locking, Coordination and Spatio-Tem- Fields of interest ing World War II.- Professor of Zoology at Harvard poral Patterns.- Phase Locking via Sinusoidal Cou- Zoology; Animal Ecology; Animal Systematics/Tax- University. The Harvard years (1953 – 2005). Evo- plings.- Pulse-Averaged [..] onomy/Biogeography lutionary biology – Mayr’s second synthesis. Ernst Fields of interest Mayr – The man. Systematics and classification.- Target groups Biophysics; Nonlinear Dynamics, Complex Systems, Zoologists Fields of interest Chaos, Neural Networks; Applications of Mathe- Evolutionary Biology; Zoology; Animal Ecology; His- matics; Neurosciences; Artificial Intelligence (incl. Type of publication tory of Science; Life Sciences, general Robotics) Reference work Target groups Target groups Graduate students, researchers Due October 2007 Evolutionary biologists, zoologists, historians Type of publication Type of publication 2007. Approx. 370 p. 78 illus., 3 in color. Hardcover Biography Monograph

189,95 € Due November 2007 Due January 2008 ISBN 978-3-540-72445-2

2008. X, 474 p., 71 illus. Softcover 2008. Approx. 320 p. (Springer Series in Synergetics) Hardcover

39,95 € 79,95 € ISBN 978-3-540-71778-2 ISBN 978-3-540-75236-3 springer.com/booksellers Life Science 51

G.S. Hall J.F. Hancock, Michigan State University, East Lansing, MI, USA S. Handwerger, University of Cincinnati College of Medicine, (Ed.) Cincinnati, OH, USA; B. Aronow, University of Cincinnati College of Medicine, Cincinnati, OH, USA (Eds.) Antifungal Agents and How to Temperate Fruit Crop Breeding Detect Resistance Genomics in Endocrinology Germsplasm to Genomics DNA Microarray Analysis in Endocrine Health and Disease

Fields of interest This book fully integrates the conventional and Microbiology biotechnological approaches to fruit crop breeding. Genomics in Endocrinology focuses on exciting new Individual chapters are written on a wide variety of advances in endocrinology resulting from DNA mi- Type of publication species including apple, apricot, blackberry, blueber- croarray studies and includes a comprehensive in- Contributed volume ry, cranberry, cherry, currant, gooseberry, grape, ki- troduction to the use of DNA microarrays in en- wifruit, peach, pear, plum, raspberry and strawberry. docrinology. The text provides the basis for further Due October 2009 For each crop, there is a discussion of their taxono- understanding of the usefulness of microarray analy- my and evolution, history of improvement, crossing ses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general 2009. 220 p. Spiral binding techniques, evaluation methods, heritability of major traits and germplasm resources, along with the most methods for the analysis of microarray data, as well 99,95 € recent advances in genetic mapping and QTL (quan- as studies of a wide variety of normal and abnormal ISBN 978-1-58829-847-8 titative trait loci) analysis, marker assisted breed- endocrine cells. ing, gene cloning, gene expression analysis, regeneration and transformation. Patenting and licensing is- Contents sues are also covered. This book will be useful in fruit Microarray-based Gene Expression Analysis of En- breeding classes and should provide as a springboard docrine Systems.- Expression Profiles and Transcrip- for all fruit breeders desiring an update on the latest tion Factors Involved in Parathyroid Hormone Sig- technologies, horticulturalists who wonder what is naling in Osteoblastic Cells.- Analysis of Growth being done in fruit breeding and genomicists search- Hormone effects on hepatic gene expression in hy- ing for a way to [..] pophysectomized rats.- Gene expression profiling in leiomyoma in response to GnRH therapy and Features TGF-b.- Gene Profiling Analysis of Androgen Re- The complete marriage of conventional and biotech- ceptor Mediated Function.- Interrogating Estrogen nological approaches to fruit breeding The coverage Receptor Signaling in Breast Cancer by Chromatin of all major fruit crops in one volume Immunoprecipitation Microarrays.- Gene expression analysis of adrenal cortex in health and disease.- Contents DNA [..] Preface.- 1. Apples;J.F. Hancock, J. J. Luby, S. K. Brown and G. A. Lobos.-2. Apricots; C. A. Ledbet- Fields of interest ter.- 3. Blackberries;C.E. Finn.- 4. Blueberries and Endocrinology; Cell Biology; Human Genetics; Mi- cranberries; J. F. Hancock, P. Lyrene, C.E. Finn, crobiology N. Vorsa and G. A. Lobos.- 5. Cherries; A. E. Iez- zoni.- 6. Currants and Gooseberries;R. M. Bren- Target groups nan.- 7. Grapes;C.L. Owen.- 8. Kwifruit;A.R. Fer- Endocrinologists, molecular and cellular biologists guson and A. G. Seal.- 9. Peaches;J. F. Hancock, R. Type of publication Scorza and G.A. Lobos.- 10. Pears;J. Hancock and Contributed volume G.A. Lobos.- 11. Plums;W.R. Okie and J. F. Han- cock.- 12. Raspberry;C. E. Finn and J. F. Hancock.- 13. Strawberry;J. F. Hancock, T. M. Sjulin and [..] Due December 2007

Fields of interest 2008. 304 p. 36 illus. (Contemporary Endocrinology) Hardcover Life Sciences, general; Plant Sciences; Plant Anato- my/Development; Plant Genetics & Genomics 109,95 € ISBN 978-1-58829-651-1 Target groups Fruit breeders across the world, and students of fruit breeding Scientists working on fruit genomics

Type of publication Monograph

Due February 2008

2008. Hardcover

150,00 € ISBN 978-1-4020-6906-2 52 Life Science springer.com/booksellers

A.L. Harris, UMDNJ - New Jersey Medical School, Newark, NJ, G.L. Hasenhuettl, Port Saint Lucie, FL, USA; R.W. Hartel, University D.L. Hawksworth, Universidad de Madrid, Spain; A.T. Bull, Univer- USA; D. Locke, UMDNJ - New Jersey Medical School, Newark, NJ, of Wisconsin, Madison, WI, USA (Eds.) sity of Kent, UK (Eds.) USA (Eds.) Food Emulsifiers and Their Biodiversity and Conservation in Connexin Biology Applications Europe A User's Guide Second Edition

This book brings together a selection of original studies submitted to Biodiversity and Conservation This book integrates theoretical background with Fields of interest that address biodiversity and conservation in Europe. practical orientation and serves as the definitive ref- Cell Biology; Pharmacology/Toxicology; Human Europe is certainly the most intensively inventoried erence on Food Emulsifiers. It offers practioners an Physiology region of the world; detailed maps are available for organized overview of the manufacture, analysis, species distributions while action plans are being physical properties, interactions and applications of Target groups drawn up for species under threat. At the same time, emulsifiers used in processed food. Written for food Cellular and molecular biologists, pharmacologists, the wildlife of Europe has been subject to enormous technologists, R & D, and product development and physiologists human pressures, with limited ‘wilderness’ sites re- personnel, it discusses the use of emulsifiers in a va- maining in most countries. Europe consequently Type of publication riety of food products including infant nutrition presents a case-study of what the human impact on Contributed volume products, baked products, confectionary products, biodiversity has been, and also what can be done to and margarine and spreads. This book also discusses improve the situation. The contributions in this vol- the application, processing, and future of emulsifiers. Due September 2008 ume are drawn from a wide range of countries and Features discuss diverse organism and habitat types. They col- 2008. Approx. 350 p. With CD-ROM. Hardcover -This book integrates theoretical background with lectively provide a snap-shot of the sorts of studies practical orientation and serves as the definitive ref- and actions being taken in Europe to address issues 103,95 € erence on Food Emulsifiers. -It offers practioners in biodiversity and conservation – topical examples ISBN 978-1-934115-46-6 an organized overview of the manufacture, analysis, that will make the volume especially valuable for use physical properties, interactions and applications of in conservation biology [..] emulsifiers used in processed food. Features Contents Draws together a wide range of peer-reviewed pri- Overview of Food Emulsifiers.- Synthesis and Com- mary research papers from biodiversity researchers mercial Preparation of Food Emulsifiers.- Analysis around the world Provides examples from a wide of Food Emulsifiers.- Emulsifier-Carbohydrate In- spectrum of issues representing the current state-of- teractions.- Protein/Emulsifier Interactions.- Phys- the art in arthropods Provides examples of recent iochemical Aspects of an Emulsifier Funtionality.- work, usable as case studies for courses in ecology, Emulsifiers in Dairy Products and Dairy Substitutes.- restoration, biodiversity, conservation Enables spe- Emulsifiers in Infant Nutritional Products.- Applica- cialist researchers to see primary research papers tions of Emulsifiers in Baked Foods.- Emulsifiers in tackling [..] Confectionery.- Margarines and Spreads.- Applica- Contents tion of Emulsifiers to Reduce Fat and Enhance Nu- From the Content: Biodiversity gradients in the tritional Quality.- Guidelines for Processing Emul- Alps.- Determining high value areas for steppe birds sion-Based Foods.- Forecasting the [..] in Spain.- The Berger?Parker index as an effective Fields of interest tool for monitoring the biodiversity of disturbed Food Science; Chemistry/Food Science, general; soils.- The effects of fire on communities, guilds Physical Chemistry and species of breeding birds in burnt and control pinewoods in central Italy.- Indicators for plant Target groups species richness in pine (Pinus sylvestris L.) forests of Students, academics, researchers, scientists in the Germany.- The social negotiation of nature conser- fields of food science, food engineering, and emul- vation policy.- Identifying new buffer areas for con- sion technology serving waterbirds in the Mediterranean basin.- Im- pact of wind turbines on birds [..] Type of publication Contributed volume Fields of interest Biodiversity; Plant Ecology; Ecology; Forestry Man- agement; Landscape Ecology Due June 2008 Target groups Originally published by CRC Press, 2004 Teachers of courses in forest biodiversity, forest conservation, forest management and sustainable for- 2008. Approx. 350 p. Hardcover est management (supplementary and reference material), research scientists and postgraduate students 61,60 € requiring an overview of current work in the same ISBN 978-0-387-75283-9 (again a supplementary and reference material).

Type of publication Contributed volume

Due November 2007

Reprinted from Biodiversity and Conservation, 16:12 (2007).

2008. Approx. 430 p. (Topics in Biodiversity and Conservation, Vol. 7) Hardcover springer.com/booksellers Life Science 53

120,00 € P. Heck, University of Appl. Sciences, Trier, Germany (Ed.) S. Heim, Free University Berlin, Germany ISBN 978-1-4020-6864-5 Material Flow Management Calories, Caoutchouc , Careers.

Systems, Technology and Finance for a Sustainable Future Plant Breeding and Agrarian Research in Kaiser-Wilhelm-Insti- tutes 1933-1945

This guidebook gives a comprehensive introduction into the optimization of energy and material sys- The book offers a history of the agricultural sci- tems, i.e., companies, cities, and counties. It com- ences in Nazi Germany. It analyzes scientific prac- bines the fields of ecology, management, technology tice under the Nazi regime, Nazi agricultural poli- and microeconomics. So the book offers the theoret- cy and autarkic strategies as well as expansion poli- ical background of material flow, it explains how to cy in Eastern Europe. It also offers new insights in- apply material flow management and thus, encour- to the Auschwitz concentration camp. It outlines the ages the reader to develop new material flow man- Nazi’s comprehensive nutritional and agricultural agement projects. An interactive web-based e-Learn- research program intended to prepare Germany for ing tool will complete the book. war by raising productivity through scientific means, researching the relation between nutrition and per- Features formance at the edge of starvation, and restructur- The book transfers visionary policies into real-life ing the agricultural economy of the continent. The applications. It is a guidance into systematic thinking book reveals the relation between science and power and an application of Material Flow Management. in Nazi Germany beyond the usual dichotomy that paints scientists in Nazi Germany either as victims of oppression or as sadistic beasts. It shows the involve- Contents ment of a high ranking scientific elite in the Nazi Theoretical background: systems, material and en- regime of occupation and looting of cultural goods ergy.- Clean technology and Technology Change in the occupied eastern territories – largely for the Management.- Environmental Politics.- MFM sake of their own careers. The main [..] and Economics.- Communication and Networking.- Applied Material Flow Manage- Features ment: Global Show-Cases and Best Practice Offers new perspectives on the cooperation between German elite scientists and the Nazi regime. Dis- Fields of interest misses the assumption that pseudo science and "Ari- Environmental Management; Renewable Energy an physics" were typical for Nazi Germany. Outlines Sources; Waste Management/Waste Technology; the Nazi project of a "modern European economy" Waste Water Technology / Water Pollution Con- based on scientific achievements. trol / Water Management / Aquatic Pollution; Envi- ronmental Economics; Technology Management Contents Introduction: Politics and Agricultural Research Target groups Calories - Agricultural Research, the Food Economy Bachelor / Master students and applied scientists and War The Four-Year Plan, 'Greater Europe', and in the fields of environmental management, ecosys- Substitute Substances Résumé: War as Oppor- tem management, industrial ecology, ecological eco- tunity Caoutchouc – A Vital War ReserveThe De- nomics and environmental technologies.- Compa- velopment of a Research Programme Slave nies as basic training course.- Municipalities and Labour for Science Résumé: Scientific Produc- Politicians tivity and Terror Careers - Hans Stubbe and Klaus von RosenstielTwo Breeding Researchers The Type of publication Advance of Science Post-War CareersRésumé: Monograph Creators, Experts, Servants Conclusions: Science, Nazi Rule and War Due April 2008 Fields of interest History of Science; Agriculture; Plant Genetics & Ge- 2008. Approx. 500 p. Hardcover nomics; History; Animal Physiology 99,95 € ISBN 978-3-540-36015-5 Target groups Anyone who is interested in the history of Nazi Ger- many and the history of agriculture, students of history of science, especially plant and animal breeding and nutritional research. Survivors of the agricultural experimental station in Auschwitz

Type of publication Monograph

Due November 2007

2008. Approx. 300 p. (Boston Studies in the Philosophy of Sci- ence, Vol. 260) Hardcover

112,00 € ISBN 978-1-4020-6717-4 springer.com/booksellers Life Science 54

H. Heine, Research Center Borstel, Germany (Ed.) R. Hell, University of Heidelberg, Germany; C. Dahl, University of Bonn, Germany; D. Knaff, University of Texas, Lubbock, USA; Th. 2008. (Advances in Photosynthesis and Respiration, Vol. 27) Leustek, Rutgers University, New Brunswick, USA (Eds.) Hardcover Innate Immunity of Plants, Animals and Humans 265,00 € Sulfur Metabolism in Phototrophic ISBN 978-1-4020-6862-1 Organisms

All living organisms are in a constant battle against their environment. Since uncontained microorganisms would simply overgrow all higher animals, the Sulfur is one of the most versatile elements in life due evolution of multicellular organisms required ade- to its reactivity in different oxidation and reduction quate and efficient defense mechanisms to protect states. In phototrophic organisms, the redox prop- their own integrity and to ensure their own survival. erties of sulfur in proteins, and of sulfur-containing These defense mechanisms, encompassing receptor metabolites, are particularly important in the inter- proteins that sense the presence of pathogens and action between the reductive assimilation processes effector molecules that are involved in controlling of photosynthesis and reactive oxygen species that them, are the elemental parts of the innate immune arise as by-products of electron transport chains. system. For many species, the innate immune system Thiol groups in proteins and metabolites are tar- is the sole active defense system. Long thought to be gets of reactive oxygen species, resulting in potential an unspecific immune response, the discovery of the damage and at the same time giving rise to redox sig- Toll-like receptors and their ligands finally revealed nal cascades that trigger repair reactions and adapta- just how specific the innate immune response actual- tion to environmental stress. Further, reduced sulfur ly is. This book wants to give an overview of our cur- compounds play a prominent role as electron donors rent knowledge about the innate immune system of for photosynthetic carbon dioxide fixation in anoxy- plants, animals and humans. It not only covers the genic phototrophic sulfur bacteria. Interest in the in- innate immune mechanisms and responses of so di- vestigation of the multiple functions of sulfur-relat- verse organisms such as plants, Cnidaria, [..] ed processes has increased exponentially in recent years, especially in molecular and cellular biology, Features biochemistry, [..] Gives an up-to-date and state-of-the-art overview of innate immunity across the evolutionary tree Features Very ancient and diverse species as well as extensive First volume that integrates knowledge on sulfur reviews of drosophila and mammalian innate im- metabolism plants, algae and phototrophic prokary- mune mechanisms are covered Gives the readership otes Comprehensive overview on phototrophic mi- a broad understanding of the current knowledge in crobial sulfur and energy metabolism Compilation this field of biochemical genomics of sulfur-driven processes in photosynthetic bacteria and plants Comprehen- Contents sive overview of plant sulfur relations from genome Evolution of Resistance Genes in Plants.- The Path to environment Less Explored: Innate Immune Reactions in Cnidari- ans.- Bug Versus Bug: Humoral Immune Responses Contents in Drosophila melanogaster.- Cellular Immune Re- Editorial.-Contents.-Preface-Author Index.-Colour sponses in Drosophila melanogaster.- Immune Reac- Plates.-I. Sulfate Activation And Reduction, Biosyn- tions in the Vertebrates’ Closest Relatives, the Uro- thesis Of Sulfur Containing Amino Acids.- 1.In- chordates.- Innate Immune System of the Zebrafish, troduction To Sulfur Metabolism In Phototrophic Danio rerio.- Toll-Like Receptors in the Mammalian Organisms.-2.Uptake, Allocation And Subcellular Innate Immune System. NLRs: a Cytosolic Armory Transport Of Sulfate.-3.Phylogenetic Analysis Of of Microbial Sensors Linked to Human Diseases. An- Sulfate Assimilation And Cysteine Biosynthesis In timicrobial Peptides as First-Line Effector Molecules Phototrophic Organisms.-4.Metabolism Of Cysteine of the Human Innate Immune System.- The [..] In Plants And Phototrophic Bacteria.-5.Metabolism Of Methionine In Plants And Phototrophic Fields of interest Bacteria.-6.Sulfotransferases From Plants, Algae And Cell Biology; Immunology; Biochemistry, general; Phototrophic Bacteria.-7.Cysteine Desulfurase-Me- Developmental Biology diated [..]

Target groups Fields of interest Immunologists, cell biologists Plant Sciences; Plant Biochemistry; Microbiology; Bacteriology; Plant Physiology Type of publication Reference work Target groups Researchers and teachers in prokaryotic and plant Due December 2007 metabolism Environment, ecology, genomics and biochemistry specialists Advanced students in microbiology, plants science, agricultural and envi- 2008. Approx. 230 p., 31 illus., 15 in color. (Nucleic Acids and ronmental studies (photosynthesis, bacterial ener- Molecular Biology, Vol. 21) Hardcover gy metabolism, biotechnology, plant nutrition, plant 119,95 € production and plant molecular physiology) Grad- ISBN 978-3-540-73929-6 uate and undergraduate students of botany and microbiology

Type of publication Contributed volume

Due January 2008 springer.com/booksellers Life Science 55

L. Hetemäki, Finnish Forest Research Institute, Helsinki, Fin- T.D. Hewitson, Royal Melbourne Hospital, Melbourne, , VIC, Aus- S.M. Hewitt, National Cancer Institute, Bethesda, MD, USA (Ed.) land; R. Sedjo, Resources for the Future, Washington, DC, USA; R. tralia; I.A. Darby, RMIT University, Bundoora, VIC, Australia (Eds.) Seppälä, Finnish Forest Research Institute, Helsinki, Finland (Eds.) Tissue Microarrays Histology Protocols Forest Products and Bioenergy Methods and Applications

Future Opportunities in Nordic Countries and North America

Fields of interest Animal Anatomy / Morphology / Histology; Cell Bi- Fields of interest Today, four countries – Canada, Finland, Sweden ology; Microbiology Cell Biology and the USA – account for up to 35-55% of the world output of forest products. Yet, faced with glob- Type of publication Type of publication alisation, southern-hemisphere plantations, rapid Contributed volume Contributed volume development of information and communication technologies, and changes in societal values, the for- Due November 2009 Due August 2009 est sectors of these countries must now either inno- vate and restructure or else face decline. To some, these changes present new opportunities – for exam- 2010. Approx. 300 p (Methods in Molecular Biology, Preliminary 2009. Approx. 400 p. (Methods in Molecular Biology, Preliminary entry 2153) Hardcover ple in the development and production of new for- entry 2239) Hardcover est biorefinery products such as biofuels and chem- 76,65 € 74,95 € icals. Indeed, the forest sector can be regarded as ISBN 978-1-60327-344-2 ISBN 978-1-58829-688-7 a central sector in moving these countries to more bioeconomy-based production and consumption. Analysing the next 20 years of forest sector development in Canada, Finland, Sweden and the USA this book provides a better understanding of the various driving forces shaping the future of the forest sector and lays the groundwork for new approaches to problems still on the horizon. With implications for both [..]

Features No comparable work has been done before Policy relevant new analysis and information Potentially large audience in forest sectors of Canada, Finland, Sweden and USA Systematic attempt to integrate forest sector and bioenergy The subject is topical in each of the countries and globally Authors well known researchers in forest community in respective countries

Contents 1. Introduction.- 2. Driving Forces Shaping the Fu- ture.- 3. Forest Products Markets and the Industry.- 4. Bioenergy.- 5. Woodfibre Markets.- 6. Implica- tions for Research and Development.- 7. Policy implications.- 8. Conclusions.-

Fields of interest Forestry; Forestry Management; Popular Science in Nature and Environment; Technology Management

Target groups People employed in forest products industry, public administration (government officials), national and international organizations, universities (researchers, students, the book is suitable at the undergraduate level), consulting.

Type of publication Contributed volume

Due May 2008

2008. Approx. 300 p. (World Forests, Preliminary entry 999) Hard- cover

115,00 € ISBN 978-1-4020-6346-6 56 Life Science springer.com/booksellers

A. Hill (Ed.) A.F. Hill, University of Melbourne, Parkville, VIC, Australia; R. Cap- D.S. Hill pai, University of Melbourne, Parkville, VIC, Australia; K. Barnham, University of Melbourne, Parkville, VIC, Australia; S.P. Bottomley, Prion Protein Protocols Monash University, Clayton, VIC, Australia (Eds.) Pests of Crops in Warmer Climates and Their Control Protein Folding, Misfolding, and

Fields of interest Disease Cell Biology A textbook providing basic data about the crop pests and the damage they inflict throughout the tropics Type of publication and sub-tropics. Each major pest is illustrated by ei- Contributed volume Fields of interest ther a line drawing or a photograph, and sometimes Cell Biology the damage can also be seen. A world distribution map is provided for each species. Control measures Due January 2009 Type of publication tend to be general rather than very specific. Most of Contributed volume the pests are insects and mites, but some nematodes, 2008. Approx. 300 p. (Methods in Molecular Biology, Preliminary molluscs, birds and mammals are included. entry 2128) Hardcover Due February 2009 Fields of interest 74,95 € Plant Sciences; Zoology; Plant Pathology; Agricul- ISBN 978-1-58829-897-3 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary ture; Invertebrates entry 2230) Hardcover Type of publication 76,65 € Monograph ISBN 978-1-60327-221-6 Due December 2007

2008. Approx. 750 p. Hardcover

165,00 € ISBN 978-1-4020-6737-2 springer.com/booksellers Life Science 57

H.-Y. Hirano, University of Tokyo, Japan; A. Hirai, Meijo University, A. Hjort-af-Ornas, Linköpings Universitet, Linköping, Sweden J. Hoffmeyer, Department of Molecular Biology, University of Nagoya, Japan; Y. Sano, Hokkaido University, Sapporo, Japan; T. Copenhagen, Denmark (Ed.) Sasaki, National Institute of Agrobiological Sciences, Tsukuba, Japan (Eds.) Turning Hydropower Social A Legacy for Living Systems Where Global Sustainability Conventions Matter Rice Biology in the Genomics Era Gregory Bateson as Precursor to Biosemiotics

This book emphasizes the importance of involving The complete sequencing of the rice genome and stakeholders in data formation related to assessments Gregory Bateson’s contribution to 20th century new molecular biological techniques have led to of hydropower development. This is a prerequiste if thinking has appealed to scholars from a wide range tremendous advances in our knowledge of rice biolo- projects are to be sustainable. The study targets poli- of fields dealing in one way or another with aspects gy. Thus rice has become an important model plant cy formation after the UNCED and UNSSD conven- of communication and epistemology. A number of for basic and applied research. This volume presents tions, and how a discrepancy emerges between poli- his insights were taken up and developed further in the latest results of research in crop improvement as cy and its implementation by using hydropower de- anthropology, psychology, evolutionary biology and well as in molecular and cellular activities in rice. It velopment as an extended case. At global and nation- communication theory. But the large, trans-disci- consists of 26 chapters and is divided into the follow- al levels new policies make it mandatory for imple- plinary synthesis that, in his own mind, was his ma- ing four sections: Genome-wide and genome-based menting agencies to introduce or expand social con- jor contribution to science received little attention research; Signal transduction and development; Evo- siderations far beyond old practices. This calls for from the mainstream scientific communities. This lution and ecology; Improvement of rice. new emphases in problem areas as well as methods book represents a major attempt to revise this defi- to optimize the access information required by poli- ciency. Scholars from ecology, biochemistry, evolu- Fields of interest cy for proper implementation. By drawing on about tionary biology, cognitive science, anthropology and Plant Genetics & Genomics; Plant Breeding/Biotech- a dozen project cases, with among others Swedish Si- philosophy discuss how Bateson's thinking might nology; Agriculture; Plant Anatomy/Development; da support, examples show how policy change has lead to a fruitful reframing of central problems in Plant Ecology; Evolutionary Biology gradually influenced project design and implementa- modern science. Most important perhaps, Bateson's tion, but also how this change process is slow and re- bioanthropology is shown to play a key role in de- Target groups liant on approvement from the dominating technical veloping the set of ideas explored in the new field of Researchers, plant breeders, agronomists, advanced and economic traditions for project assessment. The biosemiotics. The idea that organismic life is indeed students, teachers [..] basically semiotic or communicative lies at [..]

Type of publication Features Features Contributed volume Addresses the specific case of hydropower develomp- No competing titles Long overdue Reframing of cen- ment to study gaps between policy formation and tral problems in modern science Due January 2008 implementation Contents Contents 1. Angels fear revisited. Gregory Bateson's cyber- 2008. Approx. 380 p. 76 illus., 8 of them in color (Biotechnology netic theory of mind applied to religion-science de- in Agriculture and Forestry, Vol. 62) Hardcover Relating Hydropower Planning to Global Con- ventions.- Sustainable Development Issues in Hy- bates; M.C. Bateson.- 2. From thing to relation. On 199,95 € dropower Planning.- Social Catchments of Hy- Bateson's bioanthropology; J. Hoffmeyer.- 3. What ISBN 978-3-540-74248-7 dropower.- Hydropower and Regional Develop- connects the map to the territory?; T. Cashman.- 4. ment for Poverty Reduction.- Decentralisation and a The pattern which connects pleroma to creatura; T. Rights Approach in Hydropower Development.- Hy- Deacon, J. Sherman.- 5. Bateson’s method: double dropower Implementation Performance for Sustain- description; J. Hui et al.- 6. Gregory Bateson's able Development. relevance to current molecular biology; L. Bruni.- 7. Process ecology: creatura at large in an open uni- Fields of interest verse; R.E. Ulanowicz.- 8. Connections in action – Environmental Management; Nature Conservation; bridging implicit and explicit [..] Waste Water Technology / Water Pollution Con- trol / Water Management / Aquatic Pollution Fields of interest Evolutionary Biology; Philosophy of Biology; Be- Target groups havioural Sciences; Artificial Intelligence (incl. Practitioners and professionals in the fields of envi- Robotics); Social Sciences ronmental engineering and management Target groups Type of publication Individuals (researchers) and libraries including an- Monograph thropologists, psychologists, cyberneticians, and theoretical biologists, communication scientists, bio- Due December 2007 chemists, those interested in bioinformatics and ethologists, particularly in Europe but also in Amer- ica (theoretical biology has always been stronger in 2008. Approx. 300 p. (Environmental Science) Hardcover Europe thus the dominance of the Danes here as you 99,95 € can see). ISBN 978-3-540-74453-5 Type of publication Contributed volume

Due February 2008

2008. Approx. XIV, 464 p. (Biosemiotics, Vol. 2) Hardcover

130,00 € ISBN 978-1-4020-6705-1 58 Life Science springer.com/booksellers

S.D. Holdsworth, Stretton-Fosse Glos., UK; R. Simpson, Universi- M. Holmer, University of Southern Denmark, Odense, Denmark; Th.P. Holmes, USDA Forest Service, Research Triangle Park, NC, dad Técnica Federico Santa Maria, Casilla, Vaparaiso, Chile K. Black, Scottish Association for Marine Science, Dunstaffnage USA; J.P. Prestemon, USDA Forest Service, Research Triangle Marine Laboratory, Scotland; C.M. Duarte, Institut Mediterrani Park, NC, USA; K.L. Abt, USDA Forest Service, Research Triangle d'Estudis Avançats (CSIC-UIB), Spain; N. Marbà, Institut Mediter- Park, NC, USA (Eds.) Thermal Processing of Packaged rani d'Estudis Avançats (CSIC-UIB), Spain; I. Karakassis, University of Crete, Greece (Eds.) Foods The Economics of Forest Aquaculture in the Ecosystem Disturbances Thermal Processing of Packaged Foods, Second Edi- Wildfires, Storms and Invasive Species tion, discusses the physical and engineering aspects of the thermal processing of packaged foods and ex- The global expansion of aquaculture production and amines the methods that have been used to estab- its future role as a food supplier to human society This book provides a unique, state-of-the-art review lish the time and temperature of processes suitable has environmental, social and economic limitations, of both traditional and emerging themes in the eco- to achieve adequate sterilization or pasteurization of affecting marine ecosystems and socio-economic nomics of natural forest disturbances. Although nat- the packaged food. New features in this edition in- scales from local to global. The expansion is close- ural disturbances such as wildfire, hurricanes and clude: The increased use of new packaging materi- ly linked with human health requirements and soci- pests have long been recognized as important factors als, including retortable pouches and the use of con- etal needs for various goods and services provided influencing the structure and health of forests, recent tainers made from other plastic composite materials by marine ecosystems. This book provides a scientif- and dramatic increases in the costs and damages as- The application of newer processing methods which ic forecast of the development in aquaculture with sociated with forest disturbances necessitates a new use heat transfer media such as hot water, air/steam, a focus on the environmental, technological, social evaluation of these processes. The authors show that and steam/water, which are necessary for the new- and economic constraints that need to be resolved to neo-classical economic principles can be integrat- er forms of packaging material New methods of the- ensure sustainable development of the industry and ed with ecosystem analysis and modern economet- oretically calculating the heat transfer characteris- allow the industry to be able to feed healthy seafood ric methods to uncover the causes and consequences tics during processing, including three-dimensional products to the future generations. The chapters in- of natural forest disturbances. The chapters encom- modeling and application of computerized fluid dy- cluded discuss the most critical bottlenecks of the de- pass modern areas of concern in forest economics namics (CFD) techniques The implications of newer velopment encompassing subjects of understanding and policy, including temporal and spatial dynamics models for microbial destruction Revised techniques the environmental impacts, the current state-of-art of economic-ecologic systems, risk-reducing mitiga- for process evaluation using computer [..] in monitoring programs and in coastal zone manage- tion and adaptation strategies, and the valuation of ment, the important interactions between wild and impacts on market and non-market resources. These Features cultured organisms including release of [..] topics are developed with case studies demonstrating Provides an up-to-date overview of the physical and rigorous empirical analysis with a [..] engineering aspects of the thermal processing of Features packaged food Discusses methods of calculation and First interdisciplinary approach to aquaculture man- Features theoretical models used to establish the required agement Provides future perspectives based on all as- The first book to evaluate the economic aspects of time and temperature of processes necessary to en- pects of the aquaculture production (environmen- natural forest disturbances Written by leading ex- sure the required safety of the food product Presents tal, social and economically) Provides scientific state perts in the field Contains rigorous empirical anal- practical guidance on the use of various techniques of art based on numerous recent research projects yses within a policy oriented focus Integrates eco- for process evaluation Global perspectives on aquaculture Aquaculture as nomics and ecology of disturbances Systematic anal- an integrated part of the ecosystem ysis of different sources of forest disturbances in a Contents unified framework Introduction.- Heat Transfer.- Kinetics of thermal Contents processing.- Sterilization, pasteurization and cook- Foreword Fish farm wastes in the ecosystemPaul Contents ing criteria.- Heat penetration of packaged foods.- Tett Monitoring of environmental impacts of marine I. Economic-ecologic model. 1. Forest economics, Process evaluation techniques.- Quality optimiza- aquacultureMarianne Holmer, Pia Kupka Hansen, natural disturbances and the new ecology.- 2. Nat- tion.- Engineering and economics aspects of thermal Ioannis Karakassis, Joseph A Borgh and Patrick ural disturbance production functions.- 3. processing.- Retort Control.- Safety aspects of ther- J Schembri Aquaculture and coastal space man- Catastrophic wildfire risk analysis and extreme value mal processing.- Appendices A and B.- Apen- agement in Europe: an ecological perspectiveTim theory.- 4. Large versus small wildfires – what are the dices: Protocols for heat penetration studies, Com- Dempster and Pablo Sanchez-Jerez Detrimental ge- differences?.- 5. Long-term climate and wildfire rela- plete nomenclature and glossary of terms, Food Pro- netic effects of interactions between reared strains tionships.- 6. Socio-economic conditions and wild- cess Filing -FDA.- Index. and wild populations of marine and anadromous land arson.- II. Economic impacts. 7. Public policy fish and invertebrate speciesT.F. Cross, G. Burnell, J. and natural disturbances.- 8. Accounting for the eco- Fields of interest Coughlan, S. Culloty, E. Dillane, P. McGinnity and nomic impacts of forest disturbances.- 9. Fighting Food Science; Chemistry/Food Science, general E. Rogan Non-native Aquaculture Species Releases: fire with dollars: evaluating the costs of suppressing [..] Target groups wildfire.- 10. [..] Academics, students, research workers, factory man- Fields of interest Fields of interest agement and quality control staff Marine Ecology; Ecology; Environmental Manage- Forestry Management; Environmental Management; ment; Zoology Type of publication Economic Policy; Agricultural Economics; Environ- mental Economics Monograph Target groups Regulators and authorities within the field of aqua- Target groups Due November 2007 culture and coastal zone management Students and Forest policy analysts and decision-makers, risk teachers within the field of aquaculture Fish farm- managers, forest economists and graduate students ers Consultants within the field of aquaculture and 2008. Approx. 575 p. (Food Engineering Series) Hardcover studying natural resource economics. coastal zone management 114,95 € Type of publication ISBN 978-0-387-72249-8 Type of publication Contributed volume Contributed volume Due March 2008 Due December 2007

2008. Approx. 400 p. (Forestry Sciences, Vol. 79) Hardcover 2008. Approx. 270 p. Hardcover 125,00 € 129,95 € ISBN 978-1-4020-4369-7 ISBN 978-1-4020-6809-6 springer.com/booksellers Life Science 59

J.I. Horabin, Florida State University, Tallahassee, FL, USA (Ed.) R.K. Horst, Cornell University, Ithaca, NY, USA (Ed.) R.K. Horst, Cornell University, Ithaca, NY, USA (Ed.)

Hedgehog Signaling Protocols Westcott's Plant Disease Handbook Westcott's Plant Disease Handbook

In both vertebrates and invertebrates, Hedge- Westcott's Plant Disease Handbook, 7th Edition, Westcott's Plant Disease Handbook, 7th Edition, hog signaling regulates the development of should be useful to anyone with a keen interest in should be useful to anyone with a keen interest in the tissues and structures of the body. In addi- gardening including but not limited to botanical gar- gardening including but not limited to botanical gar- tion, many cancers and diseases arise as a result deners, landscape architects, florists, master garden- deners, landscape architects, florists, master garden- of misregulation of the pathway, which ers, nurserymen, seed and fungicide dealers, pesti- ers, nurserymen, seed and fungicide dealers, pesti- makes it an incredibly important system cide applicators, arborists, cooperative extension cide applicators, arborists, cooperative extension to understand. This volume examines var- agents, plant pathologists and consultants. The sev- agents, plant pathologists and consultants. The sev- ious methods used in the analysis of the Hedge- enth edition uses the traditional convenient format enth edition uses the traditional convenient format hog signaling pathway, bringing together differ- of previous editions providing easy access to essen- of previous editions providing easy access to essen- ent lines of analyses into one accessible and tial information quickly with special dictionary-type tial information quickly with special dictionary-type comprehensive text. This volume entries on plant hosts and on symptoms. New and entries on plant hosts and on symptoms. New and provides a single source for investi- updated material includes: Significant taxonomic updated material includes: Significant taxonomic gators, presenting several different changes in fungi, bacteria, viruses and nematodes changes in fungi, bacteria, viruses and nematodes experimental approaches, which are all var- Recently discovered diseases and new hosts for pre- Recently discovered diseases and new hosts for pre- ied and broad in nature, as well as procedures for viously known plant-pathogens Changes in chemi- viously known plant-pathogens Changes in chemi- a variety of different model systems. Re- cals and pesticides and changes in regulations gov- cals and pesticides and changes in regulations gov- searchers will find this volume to be an invaluble tool erning their use Integrated pest management and bi- erning their use Integrated pest management and bias they work towards deeper understanding of the ological control This book also provides useful cross ological control This book also provides useful cross underlying molecular events that the Hedgehog sig- references, indexes, illustrative plates of 34 key dis- references, indexes, illustrative plates of 34 key dis- naling pathway regulates. eases, and 40 black and white illustrations [..] eases, and 40 black and white illustrations [..]

Features Features Features Offers various detailed chapters on experimental de- Significant taxonomic changes in fungi, bacteria, Significant taxonomic changes in fungi, bacteria, scription, including anecdotal pointers and notes In- viruses and nematodes Recently discovered diseases viruses and nematodes; Recently discovered tended for Molecular Biologists, Biochemists, and and new hosts for previously known plant-pathogens diseases and new hosts for previously known plant- Geneticists Changes in chemicals and pesticides and changes in pathogens; Changes in chemicals and pesti- regulations governing their use Integrated pest man- cides and changes in regulations governing their use; Contents agement and biological control Recent research on Integrated pest management and biological Purifying the Hedgehog Protein and its Variants.- diseases that are now to be caused by virus-like (vi- control; Recent research on diseases that are Application of Sonic Hedgehog to the Developing roids) and mycoplasma-like organisms (phytoplas- now to be caused by virus-like (viroids) and [..] Chick Limb.- Manipulation of Hedgehog Signaling mas) [..] in Xenopus by Means of Embryo Microinjection and Contents Application of Chemical Inhibitors.- Isolation of Rat Contents Introduction.- Garden chemicals and their applica- Telencephalic Neural Explants to Assay Shh Gabaer- Introduction.- Garden Chemicals and Their Appli- tion.- Classification of plant pathogens.- Plant dis- gic Interneuron Differentiation- Inducing Activity.- cation.- Classification of Plant Pathogens.- Plant eases and their pathogens.- Host plans and their dis- Genetic Analysis of the Vertebrate Hedgehog Signal- Diseases and Their Pathogens.- Host Plants and eases.- List of land-grant institutions and agricultur- ing Pathway Using Muscle Cell Fate Specification Their Diseases.- List of Land Grant Institutions al experiment stations.- Glossary.- Selected biogra- in the Zebrafish Embryo.- Efficient Manipulation of and Diagnostic Laboratories.- Glossary.- Se- phies.- Index. Hedgehog/GLI Signaling Using Retroviral Expres- lected Bibliography.- Index. sion Systems.- Cell Surface Marker and Cell [..] Fields of interest Fields of interest Plant Pathology; Agriculture; Plant Sciences; Life Sci- Fields of interest Plant Pathology; Plant Sciences; Plant Physiology; ences, general Cell Biology; Animal Genetics and Genomics; Hu- Agriculture; Life Sciences, general man Genetics; Animal Biochemistry Target groups Target groups Nursery, exterior landscaper, interior landscaper, Target groups Plant Pathologists, diagnostic laboratories, consul- garden center, groundskeeper, arborists, gardening Molecular biologists, biochemists, geneticists tants, cooperative extension agents and specialists, enthusiasts, botanic garden, students, university/col- gardeners, botanical gardens, landscape architects, lege professors, teachers, extension specialists, di- Type of publication florists, nurserymen, seed and fungicide dealers, pes- agnostic laboratories, master gardeners, seed and Contributed volume ticide applicators, arborists, plant pathology class- fungicide dealers, pesticide applicators, agricultural rooms. consultants, cooperative extension agents, florists, Due October 2007 and State and Federal (FDA) plant inspectors. &nb- Type of publication sp; Handbook 2007. Approx. 335 p. 45 illus., 7 in color. (Methods in Molecular Type of publication Biology, Vol. 397) Hardcover Due March 2008 Handbook 79,95 € ISBN 978-1-58829-692-4 2008. Approx. 1030 p. Hardcover Due March 2008

299,00 € 2008. eReference. ISBN 978-1-4020-4584-4 299,00 € ISBN 978-1-4020-4585-1 60 Life Science springer.com/booksellers

R.J. Hosking, University Brunei Darussalam, Gadong, Brunei; E. S.X. Hou, National Cancer Institute, Frederick, MD, USA; S.R. M.K. Hughes, University of Arizona, Tuscon, AZ, USA; Th.W. Swet- Venturino, Università di Torino, Italia (Eds.) Singh, National Cancer Institute, Frederick, MD, USA (Eds.) man, University of Arizona, Tuscon, AZ, USA; H. Diaz, NOAA/Cli- mate Change Diagnostics Center, Boulder, Colorado, USA (Eds.) Aspects of Mathematical Modelling Germline Stem Cells Dendroclimatology Applications in Science, Medicine, Economics and Manage- ment Progress & Prospects The knowledge gained by studying germline stem cells, the source of human and animal reproduction, may find immediate application in preserving en- The construction of mathematical models is an es- With this volume we wish to bring together the dangered wildlife, managing commercial livestock, sential scientific activity. Mathematics has long been world’s leading practitioners and users of dendro- overcoming fertility problems in humans, and treat- associated with developments in the exact sciences climatology to address the question: what has been ing testicular and ovary tumors. In Germline and engineering, but more recently mathematical learned, using tree rings, about natural climate vari- Stem Cells, leading experts explore the parame- modelling has been used to investigate complex sys- ability and its environmental and social impacts? ters that define germline stem cells and the mecha- tems that arise in many other fields. The contrib- Our objectives: to review and synthesize the results nisms that regulate the cell behavior in order to bet- utors to this book demonstrate the application of of the last 30 years, and to identify the needs and op- ter isolate, characterize and maintain them. mathematics to modern research topics in ecology portunities for future work, and: to provide an au- Divided into two parts, the volume begins by pro- and environmental science, health and medicine, thoritative evaluation of the strengths and weakness- viding protocols for germline stem cell identifica- phylogenetics and neural networks, theoretical es of dendroclimatic approaches to reconstructing tion and regulation in model organisms, and con- chemistry, economics and management. past climate. cludes with detailed chapters covering cur- Features rent techniques involving in vitro culture and Contents provides examples of modern modelling applications the applications of the cells. Comprehensive and cut- Chapter 1: High-resolution Paleoclimatology – R. unusual collection of contributions from less tradi- ting-edge, Germline Stem Cells is the perfect refer- BradleyWhat is high-resolution paleoclimatology? tional fields ence for scientists exploring this particular exciting What are its major achievements? What opportuni- and important subdivision in the fast-paced ties and challenges does it now face? What should Contents field of stem cell research. dendroclimatology’s role be in this? Chapter 2: Den- From the contents Mathematical Models of Pat- droclimatology in high-resolution Paleoclimatology Features tern Formation in Planktonic Predation-Diffusion – M. K. Hughes, H. F. Diaz and Th. W. SwetnamAn Readily reproducible protocols for the manipula- Systems: A Review.- Toward a General Theory of overview of the development of dendroclimatology tion of germline stem cells in model organisms State Ecosystem Stability: Plankton-Nutrient Interaction and an introduction to the questions posed in this of the art methods optimized by leading experts in as a Paradigm.- Nutrient, Non-Toxic Phytoplank- book. Scientific bases of dendroclimatology Chapter germline stem cells Identification and regulation of ton, Toxic Phytoplankton and Zooplankton Interac- 3: How well understood are the processes that create germline stem cell in model organisms Current tech- tion in an Open Marine System.- Stability and Opti- tree-ring records? – G. Vaganov Starting [..] mal Harvesting in a Stage Structure Predator-Prey niques used in in vitro culture and application Switching Strategy.- Reducing the Emission of Pol- in germline stem cells Presents sophisticated genetic, Fields of interest lutants in Industrial Wastewater through the Use of molecular and cellular techniques used in germline Climate Change; Ecology; Tree Biology; Archaeology Membrane Bioreactors.- Insecticidal Bt Crops under [..] Massive Bt-resistant Pest Invasion: Mathematical [..] Type of publication Contents Contributed volume Fields of interest The Development of Germline Stem Cells in Drosophila.- Analysis of the C. elegans Germline Mathematical Biology in General Due October 2007 Stem Cell Region.- Immunohistological Techniques Target groups for Studying the Drosophila Male Germline Stem Researchers and postgraduate students interested in Cell.- Genetic Tools Used for Cell Lineage Tracing 2007. (Developments in Paleoenvironmental Research, Vol. 11) biomathematics and Gene Manipulation in Drosophila Germline Hardcover Stem Cells.- Structural Polarity and Dynamics of 99,00 € Type of publication Male Germline Stem Cells in an Insect (the milk- ISBN 978-1-4020-4010-8 Monograph weed bug Oncopeltus fasciatus).- High Resolution Light Microscopic Characterization of Spermato- Due December 2007 gonia.- Identification and Characterization of Sper- matogonial Subtypes and Their Expansion in Whole Mounts and Tissue [..] 2008. Approx. 325 p. (Mathematics and Biosciences in Interac- tion) Hardcover Fields of interest 129,00 € Cell Biology; Molecular Medicine; Developmental ISBN 978-3-7643-8590-3 Biology; Human Genetics Target groups Cell and molecular biologist, tissue engineers, clinicians, geneticists, and students involved in various aspects of germline stem cell research and application

Type of publication Contributed volume

Due May 2008

2008. Approx. 300 p. 55 illus. 2 in color (Methods in Molecular Biology, Vol. 450) Hardcover

76,95 € ISBN 978-1-60327-213-1 springer.com/booksellers Life Science 61

M.P. Hughes, University of Surrey, Guildford, UK; K.F. Hoettges, M.S. Humayun, Doheny Eye Institute, Los Angeles, CA, USA; J.D. W. Hunter, Horticultural Research Laboratory, Fort Pierce, FL, University of Surrey, Guildford, UK (Eds.) Weiland, Doheny Eye Institute, Los Angeles, CA, USA; G. Chader, USA; C. Kole, Clemson University, Clemson, SC, USA (Eds.) Doheny Eye Institute, Los Angeles, CA, USA; E. Greenbaum, Oak Ridge National Laboratory, TN, USA (Eds.) Microengineering in Biotechnology Genome Mapping and Genomics in

Methods and Protocols Artificial Sight Arthropods

Basic Research, Biomedical Engineering, and Clinical Ad- vances Mapping of animal genomes has generated huge Fields of interest databases and several new concepts and strategies, Biotechnology which are useful to elucidate origin, evolution and Artificial sight is a frontier area of phylogeny. Genetic and physical maps of genomes Type of publication modern ophthalmology combining further provide precise details on chromosomal lo- Contributed volume the multidisciplinary skills of surgi- cation, function, expression and regulation of aca- cal ophthalmology, biomedical engineering, biolog- demically and economically important genes. The se- Due November 2008 ical physics, and psychophysical testing. Many sci- ries "Genome Mapping and Genomics in Animals" entific, engineering, and surgical challenges must provides comprehensive and up-to-date reviews on be surmounted before widespread practical ap- genomic research on a large variety of selected ani- 2009. Approx. 375 p. (Methods in Molecular Biology, Preliminary plications can be realized. The goal of Artificial entry 2092) Hardcover mal systems, contributed by leading scientists from Sight is to summarize the state-of-the-art research around the world. Insects and other arthropods, the 99,95 € in this exciting area, and to describe some of the largest group of animals in number of species, have ISBN 978-1-58829-381-7 current approaches and initiatives that may global impact on agriculture, industry, human health help patients in a clinical setting. The Editors are and environment. They are of particular economic active researchers in the fields of artificial sight, importance for food production as pollinators, for biomedical engineering and biological physics. They natural products like silk and also as pests and par- have received numerous professional awards and asites. Arthropods covered in this volume include recognition for their work. The artificial sight team honeybee, bumblebee, the parasitic Jewel Wasp, silk- at the Doheny Eye Institute, led by Dr. Mark Hu- worm, pea aphid, mosquito, Hessian fly and tick. mayun, is a world leader in this area of biomedical engineering and clinical research. Key Features In- Features troduces and assesses the state of the art for a broad The huge amount of information hitherto dispersed audience of biomedical [..] in journals is now available in a clearly structured reference work An invaluable work that will promote Features further genomic research First book in this exciting multidisciplinary area of research Presents both a basic introduction and cut- Fields of interest ting edge research for a broad audience of biomedi- Animal Genetics and Genomics; Agriculture; Cell Bi- cal engineers, biophysicists, and clinical researchers ology; Entomology; Biotechnology; Invertebrates Describes state of the art advances in microelectronics, microfabrication, surgical implantation, and psy- Target groups chophysical testing of visual prostheses Scientists and biotechnologists in ecology, evolutionary biology, animal physiology, population genetics, Contents agriculture, entomology The DOE Medical Sciences Division's Artificial Reti- na Program.- Introduction to Artificial Sight.- Hu- Type of publication man Testing.- Neurobiology of the Degenerate Reti- Reference work na.- Effects of Blindness on the Brain.- Electrical and Thermal Effects on Neural Tissue.- Electrode Due November 2007 Technology, Packaging, Materials, Fabrication and Biotelemetry. 2008. Approx. 130 p.20 illus., 3 in color (Genome Mapping and Fields of interest Genomics in Animals, Vol. 1) Hardcover Biophysics; Ophthalmology; Biomedical Engineering 99,95 € ISBN 978-3-540-73832-9 Target groups Researchers and professionals

Type of publication Monograph

Due November 2007

2007. Approx. 485 p. 224 color illus. (Biological and Medical Physics, Biomedical Engineering) Hardcover

109,95 € ISBN 978-0-387-49329-9 62 Life Science springer.com/booksellers

J.L. Hurst, University of Liverpool, Leahurst Veterinary Field A. Ivanov, Emory University, Atlanta, GA, USA (Ed.) K.K. Jain, Jain PharmaBiotech, Basel, Switzerland Station, Neston, UK; R.J. Beynon, University of Liverpool, De- partment of Veterinary Preclinical Science, Liverpool, UK; S.C. Roberts, University of Liverpool, School of Biological Sciences, Exocytosis and Endocytosis The Handbook of Nanomedicine Liverpool, UK; T. Wyatt, University of Oxford, Office of Distance and Online Learning, Oxford, UK (Eds.)

Due to their vital involvement in a wide variety of This handbook covers the broad scope of Chemical Signals in Vertebrates 11 housekeeping and specialized cellular functions, ex- nanomedicine. Starting with the basics, the sub- ocytosis and endocytosis remain among the most ject is developed to potential clinical applications popular subjects in biology and biomedical sciences. many of which are still at an experimental stage. This volume is comprised of the proceedings of Tremendous progress in understanding these com- The prefix nano is used liberally and indicates the “Chemical Signals in Vertebrates 11”, held July 25th plex intracellular processes has been achieved by em- nano dimension of existing scientific disciples and through 28th, 2006 at the University of Chester in ploying a wide array of research tools ranging from medical specialties. Two important componants of the United Kingdom. The volume includes the lat- classical biochemical methods to modern imaging nanomedicine are nanodiagnostics and nanophar- est research on chemical communication relevant to techniques. In Exocytosis and Endocytosis, skilled maceuticals and constitute the largest chapters. vertebrates, particularly focusing on new research experts provide the most up-to-date,step-by-step Features since the last meeting in 2003. Topics covered in- laboratory protocols for examining molecular ma- Provides uniformity of style and avoids duplica- clude chemical ecology, biochemistry, behavior, ol- chinery and biological functions of exocytosis and tions as only a single author book can The physi- factory receptors, and neurobiology of both the main endocytosis in vitro and in vivo. Insightful to both cian-scientist author blends his clinical experience olfactory and vomeronasal systems of vertebrates, newcomers and seasoned professionals, Exocytosis and scientific expertise in new technologies to pro- from fish to mammals including humans. A broad and Endocytosis offers a unique and highly practical vide a definitive account of nanomedicine Complete range of taxonomic groups and topics are discussed, guide to versatile laboratory tools developed to study with a more up-to-date and comprehensive including a special section on human olfaction and various aspects of intracellular vesicle trafficking in coverage of nanomedicine than any other compara- response to human scents, interspecific respons- simple model systems and living organisms. ble work es (predator/prey and alarm cues), intraspecific re- Features sponses, and the neural basis of chemical signaling. Provides classic, state of art, and cutting edge meth- Contents Introduction.- Nanotechnologies.- Nanomolecu- Features ods in a simple, easily reproducible format Contains lar Diagnostics.- Nanopharmacceuticals.- Role of Presents the newest research in chemical commu- a comprehensive set of experimental models includ- Nanotechnology in Biological Therapies.- Nanode- nication of vertebrates Includes the potential appli- ing cell-free systems, different specialized cells, and vices for Medicine & Surgery.- Nanooncol- cation of novel techniques currently used in inver- model organisms Presents detailed lists of tested ogy.- Nanoneurology.- Nanocardiology.- Nano- tebrate systems Covers a broad range of taxonomic reagents that really work Notes on troubleshooting orthopedics.- Infectious Diseases.- Application of groups, including humans from leading laboratories in the field Nanobiotechnology in Ophthalmology.- Regenera- Contents Contents tive Medicine & Tissue Engineering.- Miscel- Preface.- Contents.- List of Contributors.- Part I: Vesicular Trafficking: Molecular Tools and Targets.- laneous Applications.- Ethical, Safety and Regula- New Directions in Semiochemistry.- Part II: Olfac- Pharmacological Inhibition of Endocytic Pathways. tory issues of Nanomedicine.- Worldwide Develop- tory Response and Function.- Part III: Recognition Is It Specific Enough to be Useful?.- In Vitro As- ment and Commercialization of NanoMedicine.- Re- Within Species: Individual, Sex, Group.- Part IV: says to Measure SNARE-Mediated Vesicle Fusion.- search and Education in Nanomedicine.- Future of Sexual Communication.- Part V: Maternal - Off- Imaging Ca2+-Triggered Exocytosis of Single Secre- Nanomedicine. spring Communication.- Part VI: COMMUNICA- tory Granules on Plasma Membrane Lawns from Fields of interest TION Between Species, Predators and Prey.- Part Neuroendocrine Cells.- FRAP Analysis of Secretory Biotechnology; Nanotechnology; Pharmacolo- VII: Applications.- Index. Granule Lipids and Proteins in the Sea Urchin Egg.- A Cell-Free Assay for Endocytosis of E-cadherin.- gy/Toxicology; Molecular Medicine; Cancer Re- Fields of interest Cell-Surface Biotinylation to Study Endocytosis and search Behavioural Sciences; Neurobiology; Evolutionary Recycling of Occludin.- Fractionation of Subcellular Target groups Biology; Animal Biochemistry; Animal Ecology; Zo- Membrane Vesicles of Epithelial and [..] Scientific researchers, medical clinicians, biotech- ology Fields of interest nologists, pharmaceutical research and developers, Target groups Cell Biology; Human Physiology; Developmental Bi- physicians, and molecular biologists Researchers in chemical ecology, animal behaviour, ology; Immunology; Neurobiology Type of publication neuroscience, evolutionary biology, psychology, bio- Monograph chemistry, ecology, and zoology Target groups Cell biologists, physiologists, developmental biolo- Type of publication gists, immunologists, and neurobiologists Due April 2008 Proceedings Type of publication Contributed volume 2008. Approx. 315 p. 10 illus. Hardcover Due December 2007 92,95 € Due April 2008 ISBN 978-1-60327-318-3 2008. Approx. 400 p. Hardcover

134,95 € 2008. Approx. 495 p. 79 illus. 5 in color (Methods in Molecular ISBN 978-0-387-73944-1 Biology, Vol. 440) Hardcover 76,95 € ISBN 978-1-58829-865-2 springer.com/booksellers Life Science 63

K.K. Jain, Jain PharmaBiotech, Basel, Switzerland (Ed.) S.M. Jain, University of Helsinki, Finland; S.J. Ochatt, Institut Na- S.M. Jain, University of Helsinki, Finland; P.K. Saxena, University tional de la Recherche Agronomique, UMRLEG, PCMV, Dijon, of Guelph, ON, Canada (Eds.) France (Eds.) Drug Delivery Systems Protocols for In Vitro Cultures and Protocols for In Vitro Propagation Secondary Metabolite Analysis of of Ornamental Plants The field of drug development and therapeutics can Aromatic and Medicinal Plants be overwhemingly encyclopedic and vast. In Drug Delivery Systems, Dr. Kewal Jain and a team of experts select the most important, cutting-edge technologies used in drug delivery systems taking into Fields of interest This book provides a detailed step-by-step descrip- account significant drugs, new technologies such Plant Anatomy/Development; Plant Sciences; tion of protocols for the establishment of in vitro cul- as nanoparticles, and therapeutic applications. The Biotechnology tures of important medicinal plants, their mass mul- chapters present step-by-step laboratory protocols tiplication in controlled environment, and step-wise following the highly successful Methods in Molec- Target groups secondary metabolite analysis. In addition, many of ular Biology™ series format, offering readily repro- Floricultrists, commercial companies, biotechnolo- these protocols will provide a basis for much need- ducible results vital for pharmaceutical physicians gists, and students ed efforts in germplasm conservation of medicinal and scientists. Concise and systematic, Drug Deliv- species at the brink of extinction. Medicinal plant ery Systems is a powerful reference tool for the hun- Type of publication species are diverse and distinct in their growth pat- dreds of companies developing drug delivery tech- Contributed volume terns and their yield must be defines it terms of nologies all around the world. chemistry and in vitro cultures provide the vehicle Due April 2009 to accomplish this objective. A comprehensive com- Features pilation of technical details and protocols for in vit- Contains important drug discovery information ro culture of medicinal plants is not currently avail- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary able. The proposed is expected to be well received in Concise reference for pharmaceutical physicians and entry 2244) Hardcover scientists academia, industry, and Government agencies. 76,65 € Contents ISBN 978-1-60327-390-9 Contents Drug delivery systems: an overview.- The Role of the St. John’s wort (Hypericum perforatum L.).- Black Adeno-associated Virus Capsid in Gene Transfer.- henbane (Hyoscyamus niger).- Palmarosa (Cymbo- Delivering small interfering RNA for novel therapeu- pogon martini).- Curry leaf tree (Murraya koenigii).- tics.- Catheters for Chronic Administration of Drugs Tinospora cordifolia.- Potentilla potaninii.- Taxus into Brain Tissue.- Transdermal Drug Delivery Sys- baccata.- Scrophylaria yoshimurai.- Lycium bar- tems: Skin Peturbation Systems.- Controlling the Re- barum.- Kalanchoe daigremontiana.- Valeriana fau- lease of Proteins/Peptides via the Pulmonary Route.- riei.- Berry cell culture.- Ginseng.- Thalictrum sim- Engineering Protein Particles for Pulmonary Deliv- plex.- Centella asistica.- Catharanthus roseus.- Cen- ery.- 2B-Trans™ technology: targeted drug delivery taurea rupestris.- Gossypol in cotton.- Capsicum across the blood-brain barrier.- Drug delivery in can- spp..- Strawberry flavonoids.- Cassia angustifolia.- cer using liposomes.- pH-Responsive Nanoparticles Echinacea purpurea.- Solanum dulcamara.- Pogoste- for Cancer Drug Delivery.- [..] mon cablin.- Spilanthes acmeila.- Malloutus [..]

Fields of interest Fields of interest Biotechnology; Pharmacology/Toxicology; Molecu- Pharmacology/Toxicology; Plant Sciences; Plant Bio- lar Medicine; Biochemistry, general; Immunology chemistry

Target groups Type of publication Pharmaceutical scientists, academic pharmacolo- Contributed volume gists, pharmaceutical physicians Due May 2009 Type of publication Contributed volume 2009. Approx. 300 p (Methods in Molecular Biology, Preliminary entry 2236) Hardcover Due April 2008 76,65 € 2008. Approx. 260 p 55 illus. (Methods in Molecular Biology, Vol. ISBN 978-1-60327-286-5 437) Hardcover

76,95 € ISBN 978-1-58829-891-1 64 Life Science springer.com/booksellers

Th. Jakl, Federal Ministry of Agriculture, Vienna, Austria; P. Schwager, UNIDO, Vienna, Austria (Eds.)

Chemical Leasing goes global

Selling Services Instead of Barrels: A Win-Win Business Model for Environment and Industry

Chemical Leasing is an innovative business model for the sustainable management of chemicals where the economic benefit is achieved by selling services. It provides adequate chemicals risk management coupled with environmental advantages and economic benefits for both the user and the producer. Within Chemical Leasing business models, the responsibility of the producer and service provider is extended and may include the management of the entire life cycle. The application of Chemical Leas- ing was assisted and monitored in a broad range of sectors and companies. This book collects the experience gained from pilot projects in Austria, Egypt, Russia and Mexico. In developing countries and countries with economies in transition the new business model was successfully implemented in cooperation with UNIDO’s worldwide Cleaner Production Programme, supported by the Austrian Federal Gov- ernment. This book contains detailed descriptions and evaluations based on existing projects, as well as political and [..]

Features Presentation of the innovative business model “Chemical Leasing” Collects the experience gained from pilot projects Representative results of an extensive study

Contents From the contents Chemical Leasing - An Introduc- tion (Thomas Jakl).- Cleaner Production and Chem- ical Leasing (Petra Schwager).- The Theory behind Chemical Leasing (Reinhard Joas).- Chemical Leas- ing in Austria - Case Studies.- Chemical Leasing In- ternational - Case Studies.- Third-Party Quality As- surance and Certification (Schaff/Nagel).- Legal As- pects of Chemical Leasing (Michael Wittmann).- Chemical Leasing Toolkit (UNIDO).- Scientific observation - Chemical Leasing and the Reduction of Negative External Effects: "Property Rights" Ap- proach (Frank Moser).- Chemical Leasing Profit Sharing [..]

Fields of interest Ecology; Applied Ecology; Environmental Eco- nomics; Technology Management

Target groups Chemists, ecologists, experts of environment, economists

Type of publication Professional book

Due November 2007

2008. Approx. 200 p. 10 illus. Softcover

59,95 € ISBN 978-3-211-73751-4 springer.com/booksellers Life Science 65

S. Jakowlew, National Cancer Institute, Rockville, MD, USA (Ed.) R. Javaherdashti, Extrin Consultants, Canning Vale, WA, Australia P. Jeanteur, CNRS, Montpellier, France (Ed.)

Transforming Growth Factor-Beta Microbiologically Influenced RNA Trafficking and Nuclear in Cancer Therapy Corrosion Structure Dynamics

Volume I, Basic and Clinical Biology An Engineering Insight

Over the last few years remarkable progress has been accomplished with respect to our under- Transforming Growth Factor- ß in Cancer Thera- Microbiologically-influenced corrosion (MIC) is one standing of nuclear structure and trafficking. This py, Vols. 1 and 2, provides a compendium of find- of the greatest mysteries of corrosion science and en- volume concentrates on aspects that involve ings about the role of transforming growth factor- ß gineering, due to the complexities resulting from the or are of relevance to RNA and RNPs. Topics include (TGF- ß) in cancer treatment and therapy. The first involvement of living things such as bacteria. Bacte- fundamental advances and current problems in the volume, Basic and Clinical Biology, is divided into ria are not only able to affect our health, but are al- structural organization of different subnuclear com- three parts. Part I presents basic concepts of trans- so capable of impacting upon everyday life through partments: chromatin, nucleolus and perinucleo- forming growth factor- ß signaling in normal phys- a wide range of industrial sectors and the economy. lar compartment, Cajal bodies and gems, speckles iology and cancer pathobiology. Part II investigates Microbiologically Influenced Corrosion: An Engi- containing splicing factors, as well as the PML bod- transforming growth factor- ß superfamily members neering Insight introduces a new approach to the ba- ies characteristic of ProMyelocytic Leukemia. It also in normal and tumor biology. The final part details sics of MIC and explains how to recognise, under- describes recent progress in the dynamic aspects of transforming growth factor- ß in inflammation and stand, mitigate and/or prevent this type of corrosion. RNA trafficking and in the latest technologies for live fibrosis. This volume’s companion, Cancer Treat- Topics explored include stress corrosion cracking cell imaging of mRNA. The major general message ment in Therapy, examines transforming growth fac- and microbial corrosion, the pros and cons of bio- of this volume is that nuclear structure is much more tor- ß in other developing and advanced cancers and cides, the involvement of magnetic bacteria in micro- dynamic than previously anticipated. methods of treatment and therapy. Together, Trans- bial corrosion, and a new interpretation of cathodic forming Growth Factor- ß in Cancer Therapy, Vols. protection based on recent research in microbial en- Features 1 and 2, provide researchers and clinicians a compre- vironments. The material covered by Microbiologi- First book to describe the latest research results in hensive and cutting-edge reference for the findings cally Influenced Corrosion: An Engineering Insight nuclear structure dynamics with a focus on RNA and about the role of transforming growth factor- ß in bi- will be of benefit to professional and consultant engi- RNPs (Ribonucleic acid/Ribonucleic proteins) ology and cancer treatment. neers in power generating, oil and [..] Contents Features Features Nuclear Organization and Subnuclear Bodies.- In-depth detail of basic concepts of TGF-ß in normal Explains how to recognise, understand, mitigate and/ Searching For Active Ribosomal Genes.- Toxic RNA physiology and cancer pathobiology Conveniently or prevent microbiologically-influenced corrosion in the Nucleus: Unstable Microsatellite Expression in divided into three easy-to-follow parts Companion (MIC) Neuromuscular Disease.- Traffic and Biogenesis of volume details cancer treatments and therapies Small Nuclear RNA.- Intranuclear Pre-mRNA Traf- Contents ficking in an Insect Model System.- Photobleaching Contents A Short Journey to the Realm of Corrosion.- Tech- Microscopy Reveals the Dynamics of mRNA Binding Component Hardware for Transforming Growth nical Mitigation of Corrosion:Corrosion Manage- Proteins Inside the Living Cell.- Imaging of Single Factor-ß Signal Transduction: TGF-ß Ligands, TGF- ment.- Non-technical Mitigation of Corrosion: Cor- mRNAs in Living Cells. ß Receptors, and Smads.- TGF-ß Signaling in Home- rosion Knowledge Management.- Microbiologically ostasis and Cancer.- TGF-ß Availability: Latent TGF- Influenced Corrosion (MIC).- How Does A System Fields of interest ß and Latent TGF-ß Binding Proteins.- Biologi- Become Vulnerable to MIC?- How is MIC detected Cell Biology; Molecular Medicine; Biochemistry, cal Functions of Latent TGF-ß Binding Proteins and recognised?- Examples of Some Systems Vulner- general and Activation of TGF-ß.- Regulators of Smad2/3 able to MIC.- Examples of Some Materials Vulnera- Transcription and Phosphorylation.- Interaction of ble to MIC.- How is MIC treated? Target groups Smad4 and Embryonic Liver Fodrin (ELF)-ß-spec- Scientists, graduates, lecturers, advanced students trin in Hyperplasia, Neoplasia, and Tumor Progres- Fields of interest sion.- Regulation of Smad Activity by Phosphoryla- Tribology, Corrosion and Coatings; Biochemical En- Type of publication tion.- Nuclear Targeting of TGF-ß-activated Smads gineering; Continuum Mechanics and Mechanics of Monograph in Normal and [..] Materials; Civil Engineering; Microbiology Due November 2007 Fields of interest Target groups Oncology; Cell Biology; Cancer Research; Pharma- Professional engineers in power generating, oil and cology/Toxicology gas, marine, and mining industries; researchers in 2007. IX, 153 p. 28 illus., 8 in color. (Progress in Molecular and the fields of chemistry, chemical engineering, materi- Subcellular Biology, Vol. 35) Softcover Target groups als science, corrosion, and mechanical engineering; 59,95 € Molecular and cell biologists, cancer researchers, consultant engineers. ISBN 978-3-540-74265-4 pharmacologists Type of publication Type of publication Monograph Contributed volume Due February 2008 Due January 2008 2008. Approx. 220 p. (Engineering Materials and Processes) Hard- 2007. Approx. 700 p. 135 illus. (Cancer Drug Discovery and Devel- cover opment) Hardcover 79,95 € 134,95 € ISBN 978-1-84800-073-5 ISBN 978-1-58829-714-3 66 Life Science springer.com/booksellers

M.G. Jones, Imperial College School of Medicine at the National S. Jose, University of Florida, Gainesville, FL, USA; A.M. Gordon, Th. Jue, University of California Davis, Davis, CA, USA (Ed.) Heart & Lung Institute, London, UK; P. Lympany, Imperial College University of Guelph, ON, Canada (Eds.) School of Medicine at the National Heart & Lung Institute, Lon- don, UK (Eds.) Protein and Sub Cellular Structure- Toward Agroforestry Design Function Allergy Methods and Protocols An Ecological Approach

In keeping with goal and style of the Handbook in Allergy: Mechanisms and Protocols aims to assist Jose and Gordon’s “Toward Agroforestry Design” Modern Biophysics series, the proposed book will the researcher in gaining insight into the molecular is an important reference for anyone interested in maintain a chapter structure that contains two parts: mechanisms involved in allergy by featuring an ar- exploring or managing the physiological and eco- concepts and biological application. The book also ray of protocols. The protocols cover a range of dis- logical processes which underlie resource allocation integrates all the chapters into a smooth, continuous ciplines including allergy, immunology, cell biology, and plant growth in agroforestry systems. Draw- discourse. The first and second chapters establish and histology, and include methods to investigate the ing together a wide range of examples from around the mathematical methods and theoretical frame- cellular response to allergens, cytokine profile, MHC the world, the book highlights how recent develop- work underpinning the different topics in the rest restriction, and T regulatory cells. ments in agroforestry research can contribute to un- if the book. Other chapters will use the theoretical derstanding agroforestry system function, and dis- framework as a basis to discuss optical and NMR ap- Features cusses the potential application of agroforestry in ad- proaches. Each chapter will contain innovative di- Aims to assist the researcher in gaining insight in- dressing a range of land use challenges in both trop- dactic elements that facilitate teaching, self-study, to the molecular mechanisms involved in allergy by ical and temperate regions of the world. Including and research preparation (key points, summary, ex- featuring an array of protocols The protocols cover a both original research and synthetic analyses, the ercise, references). range of disciplines book presents examples from a wide range of environments. It focuses largely on resource allocation – Contents Contents both above and below-ground – including an assess- Concepts in Protein Folding.- Local Mem- Understanding the Molecular Mechanisms of Al- ment of the recent advances in analatyical and mod- brane Structure and Dynamics.- Raman Spec- lergy.- T Cell - Primary Culture from Peripheral eling tools available to this work, Concluding with troscopy in Biology.- Fluorescence Resonance En- Blood.- Production of T Cell Lines.- Production of a synthesis of the key questions and research gaps ergy Transfer as a Molecular Ruler.- Time Resolved Human T Cell Clones.- Mapping oo Human T-Cell highlighted throughout the text, the book will be [..] Fluorescence Spectroscopy.- Fluorescence Imaging Epitopes of Allergens.- Determining MHC Restric- of Intracellular Ca2+ Dynamics.- High Resolution tion of T Cell Response.- Short Term Culture of CD8 Features NMR Study of Ca2+ Sensing Proteins.- NMR Inves- Cells And Intracellular Cytokine Staining.- Isolation, Excellent coverage of recent advances in ecological tigation of Paramagnetic Molecules. Flow Cytometric Analysis And Suppression Assay knowledge in agroforestry systems Covers both tem- of CD4+CD25+ T Regulatory Cells.- Monocyte-De- perate and tropical regions of the world Separate sec- Fields of interest rived Dendritic Cells As Antigen Presenting Cells in tions to cover aboveground resource allocation and Biophysics; Biochemistry, general; Optical Spec- T Cell Proliferation and Cytokine Production.- Ul- ecological processes, belowground processes and re- troscopy, Ultrafast Optics; Imaging / Radiology; Cell trasensitive ELISA For Measurement of Human Cy- source use, and modelling and analytical tools Syn- Biology tokine [..] thesis chapter that identifies knowledge gaps Target groups Fields of interest Contents Biophysicists, biochemists, cell biologists, imaging Allergology; Cell Biology; Immunology; Molecular From the contents 1. Ecological knowledge and agro- specialists Medicine forestry design.- 2. Biophysical changes resulting from 16-years of riparian forest rehabilitation.- 3. Type of publication Target groups Ecological development and function of shelterbelts Contributed volume Allergists, immunologists, immunotherapists, cell bi- in temperate North America.- 4. Forage production ologists, histologists, molecular biologists under and adjacent to 'Robinia pseudoacacia' in cen- Due July 2008 tral Appalachia, West Virginia.- 5. Light intensity ef- Type of publication fects on growth and nutrient use efficiency of tropi- Contributed volume 2008. Approx. 450 p. (Handbooks of Modern Biophysics Tech- cal legume cover crops.- 6. Interspecific competition niques) Hardcover in a pecan-cotton alleycropping system in the south- Due November 2007 ern United States.- 7. Modification of microclimate 111,65 € and associated food [..] ISBN 978-1-60327-232-2 2007. Approx. 380 p. 40 illus., 1 in color. (Methods in Molecular Medicine, Vol. 138) Hardcover Fields of interest Forestry; Plant Ecology; Plant Physiology; Ecology; 99,95 € Agriculture ISBN 978-0-89603-896-7 Target groups Researchers, agroforestry practitioners, extension professionals, undergraduate and graduate students

Type of publication Contributed volume

Due October 2007

2008. Approx. X, 310 p. (Advances in Agroforestry, Vol. 4) Hard- cover

149,95 € ISBN 978-1-4020-6571-2 springer.com/booksellers Life Science 67

G. Jékely, European Molecular Biology Laboratory, Heidelberg, C.S. Kaetzel, University of Kentucky, Lexington, KY, USA (Ed.) A. Kamkin, Russian State Medical University, Moscow, Russia; I. Germany (Ed.) Kiseleva, Russian State Medical University, Moscow, Russia (Eds.) Mucosal Immune Defense: Eukaryotic Membranes and Immunoglobulin A Mechanosensitive Ion Channels Cytoskeleton

Origins and Evolution This book presents the latest findings in Immune responses at mucosal surfaces play a ma- mechanosensitive ion channel research compiled jor role in host mucosal defense against microbial by a number of internationally recognized experts pathogens and in the pathogenesis of acute and Eukaryotic Membranes and Cytoskeleton: Origins in the field of mechanosensitivity, specializing in chronic mucosal inflammatory diseases. This vol- and Evolution discusses the evolutionary origin and mechanosensitive or mechanically gated ion chan- ume draws on a broad spectrum of molecular biolog- diversification of eukaryotic endomembranes and nels and the underlying mechanosensitive signal- ic, biochemical, and immunogenetic approaches in cytoskeleton from a cell biological and comparative ing cascades. "Mechanosensitivity in Cells and Tis- combination with human and murine in vitro cell genomic perspective. Many of the chapters present sues: Mechanosensitive Ion Channels" defines and culture and in vivo model systems to address ques- original research data from comparative genomic discusses key problems of cellular mechanobiology, tions in mucosal immunity. Humans produce more surveys. The presence/absence of gene families with describing the methods for studying mechanosensi- immunoglobulin A (IgA) than all other antibody iso- central roles in endomembrane and cytoskeleton dy- tive ion channels, the role of lipid bilayer mechan- types combined, most of which is rapidly transport- namics in a variety of eukaryotic taxa and an under- ics in mechanosensation, and the molecular orga- ed into the external secretions bathing mucous mem- standing of eukaryote phylogeny allow us to accu- nization, physiology and pharmacology of the vari- branes. It has been estimated that more than 3 grams rately reconstruct the cellular machineries present in ous ion channels, which react to changes in cellular of IgA are transported daily into mucosal secretions, the last common ancestor of eukaryotes. Such a re- membrane tension. The book provides a comprehen- carrying out a wide range of antimicrobial and an- construction is fundamental if we are to understand sive description of mechanotransduction, which is ti-inflammatory functions. IgA is the second most eukaryotic diversification since this is the ancestral defined as the biochemical response of cells to me- abundant class of antibody in the bloodstream, con- cell from which all diversity arose. Comparative ge- chanical stimulation, and provides the reader with tributing to systemic as well as secretory immunity. nomics can likewise tell us which lineages expanded the latest vision of signaling cascades. These signal- Recent advances in human genomics, gene regula- or reduced certain gene families and the associated ing cascades play an important role in modulation of tion, structural biology, cell signaling, and immuno- cellular machineries. function of [..] biology have greatly [..] Features Features Features Diversity of viewpoints on many aspects of eukaryote One book concentrates on basic information on The very first publication to specifically address the evolution Examines the problems along some tran- mechanosensitive ion channels One book con- role of IgA in mucosal defense immunology sects of eukaryote cell biology centrates on basic information on mechanosensi- Contents tive signaling cascades Covers basic ideas on cell Contents Structure of IgA.- IgA Plasma Cell Development.- mechanobiology Criticizes a number of points con- Preface.- The Early Eukaryotic Fossil Record.- The Epithelial Transport of IgA by the Polymeric Im- sidered acute in the recent years Gives a wide and de- Diversity of Eukaryotes and the Root of the Eukary- munoglobulin Receptor.- Fc Receptors for IgA.- Reg- tailed coverage of the problem as a whole otic Tree.- Origin of Eukaryotic Endomembranes: ulation of the Mucosal IgA System.- Biological Func- A Critical Evaluation of Different Model Scenarios.- Contents tions of IgA.- Protection of Mucosal Epithelia by Origins and Evolution of Cotranslational Transport Foreword I.- Foreword II.- Editorial Mechanical- IgA: Intracellular Neutralization and Excretion of to the ER.- Evolution of the Endoplasmic Reticulum ly gated channels and mechanosensitive channels.- Antigens.- Novel Functions of Secretory IgA.- IgA and the Golgi Complex.- An Evolutionary Perspec- Part I. Mechanosensitive Channels.- Experimen- and Antigen Sampling.- IgA and Intestinal Home- tive on Eukaryotic Membrane Trafficking.- Recon- tal methods of studying of mechanosensitive chan- ostasis.- IgA and Respiratory Immunity.- IgA and structing the Evolution of the Endocytic System: In- nels and possible errors in data interpretation.- The Reproductive Tract Immunity.- IgA-Associated Dis- sights from Genomics and Molecular Cell Biology.- role of lipid bilayer mechanics in mechanosensa- eases.- Mucosal SIgA Enhancement: Development of Origins and Evolution of the Actin Cytoskeleton.- tion.- Mechanosensitive channels gated by mem- Safe and Effective Mucosal Adjuvants and Mucosal Origin and Evolution of Self-Consumption: [..] brane tension: bacteria and beyond.- Computational [..] approaches in studies of bacterial mechanosensitive Fields of interest Fields of interest channels.- Mechanosensory transduction in the ne- Eukaryotic Microbiology; Cell Biology; Evolutionary Immunology; Microbiology; Infectious Diseases; Vi- matode Caenorhabditis elegans.- Mechanosensitive Biology; Human Genetics rology; Pharmacology/Toxicology; Allergology ion channels in odontoblasts.- Potassium ion channels in [..] Target groups Target groups Experimental cell biologists Researchers, scientists, professionals, clinicians, Fields of interest physicians, and graduate students in the fields of Im- Cell Biology; Animal Physiology; Biophysics; Physio- Type of publication logical, Cellular and Medical Topics Contributed volume munology, Microbiology, Infectious Disease, Virolo- gy, Pharmacology, Allergology, Oral Tolerance, and Target groups Medicine Due October 2007 Physiologists, biophysicists, molecular biologists, Type of publication pharmacologists, geneticists, doctors Contributed volume 2007. 162 p. (Advances in Experimental Medicine and Biology, Type of publication Vol. 607) Hardcover Contributed volume Due November 2007 114,95 € ISBN 978-0-387-74020-1 Due October 2007 2008. X, 446 p. 41 illus. Hardcover

99,95 € 2008. Approx. 400 p. (Mechanosensitivity in Cells and Tissues, Vol. 1) Hardcover ISBN 978-0-387-72231-3 119,95 € ISBN 978-1-4020-6425-8 68 Life Science springer.com/booksellers

A. Kangas, University of Helsinki, Finland; J. Kangas, C. Kannicht, Octapharma, Berlin, Germany (Ed.) P. Karlovsky, University of Goettingen, Germany (Ed.) Metsähallitus, Vantaa, Finland; M. Kurttila, University of Joensuu, Finland Post-translational Modification of Secondary Metabolites in Soil Decision Support for Forest Proteins Ecology Management Tools for Functional Proteomics, Second Edition

Secondary Metabolites in Soil Ecology focus on the role of bacterial, fungal and plant secondary metabo- The majority of all proteins undergo co- and/or post- The goal of Kangas, Kangas & Kurttila's Deci- lites in soil ecosystems. Our understanding of the translational modifications, crucially altering physi- sion Support for Forest Management is to provide biological function of secondary metabolites is sur- cal and chemical properties, folding, conformation students and researchers with a toolbox of methods prisingly limited, considering our knowledge of their distribution, stability, activity, and, consequently, the for approaching the different planning situations structural diversity and pharmaceutically relevant function of the proteins. In Post-translational that may arise in practice. It draws together a wide activities. The volume reviews functional aspects of Modification of Proteins: Tools for Functional Pro- range of methods used in planning forest manage- secondary metabolite production, with a focus on teomics, Second Edition, this important area ment regimes and presents a systematic overview interactions among soil organisms. Topics such as of research is brought up-to-date by the lead- of current methodological approaches. While earli- truffle metabolites and burnt phenomenon, ecology ing scientists in the field. This compilation er books concerning forest planning have tended to of mycotoxins in soil, root exudates, and chemical of detailed protocols focuses on protein function, focus on linear programming, economic aspects, or interactions between Streptomyces and mycorrhiza proteome research and characterization of pharma- specific multi-criteria decision aid tools, this book fungi are treated. Further aspects are the role of mi- ceutical proteins, while following the successful for- provides a much broader range of tools to meet a va- crobial metabolites as quorum sensing signals, their mat of the Methods in Molecular Biology™ series. riety of planning situations. The methods themselves role in protecting plants against pathogens and the Comprehensive and cutting edge, Post-translational cover a range of decision situations – from cases in- effect of volatiles on soil invertebrates. Chapters de- Modification of Proteins: Tools for Functional Pro- volving single decision makers, through group deci- scribing techniques for the detection of antibiotics teomics, Second Edition serves as practical guide sion making, to participatory planning. They include in soil and the application of metabolomics to rhizo- for researchers working in the field of protein struc- traditional decision support tools, from optimization sphere research, which has advanced rapidly in re- ture-function relationships and the rapidly to utility functions, as well as methods that are just cent years, complement the book. gaining ground in forest planning – such as problem growing field of proteomics, as well as scientists in structuring methods and social choice [..] the pharmaceutical industries. Features First book that focuses mainly on the biological and Features Features ecological role of secondary metabolites No other book includes methodology for all aspects A fully up-dated and expanded practical guide to of forest planning, ranging from operations research protein structure-function relationships Most com- Fields of interest methodology to ethical aspects of participation Com- prehensive volume on PTM analysis available today Terrestial Ecology; Microbial Ecology; Plant Bio- prehensive list and assessment of models and meth- Contains cutting-edge methods in the most high in- chemistry; Agriculture; Soil Science & Conservation ods for forest management planning. No other text- terest areas of the field Provides easy-to-follow, read- book covers so many approaches and techniques In- ily reproducible protocols and time-saving notes Target groups tegration of multi-criteria topics Chapters 8, 10 and Researchers in microbiology, soil sciences, plant sci- 11 are unique Contents ences, terrestrial ecology Disulfide Bond Mapping by Cyanylation-Induced Contents Cleavage and Mass Spectrometry.- Detection of Type of publication 1. Introduction. 2. Unidimensional problems.- 3. Post-Translational Modifications by Fluorescent Contributed volume Multi-criteria decision problems.- 4. Uncertainty in Staining of 2D gels.- Identification of Protein Phos- multi-criteria decision making.- 5. Optimization.- 6. phorylation Sites by Advanced LC-ESI-MS/MS Due December 2007 Heuristic optimization.- 7. Group decision making Methods.- Analysis of Tyrosine-O-Sulfation.- a - and participatory planning.- 8. Voting methods.- 9. Amidated Peptides: Approaches for Analysis.- Gam- Behavioural aspects.- 10. Practical examples of using ma-Glutamate and b -Hydroxyaspartate in Proteins.- 2008. Approx. 300 p. (Soil Biology, Vol. 14) Hardcover Lysine Hydroxylation and Cross-linking of Colla- MCDS methods.- 11. Final remarks.- 129,95 € gen.- Mass Spectrometric Determination of Protein ISBN 978-3-540-74542-6 Fields of interest Ubiquitination.- Analysis of Sumoylation.- Detec- Forestry Management; Operation Research/Deci- tion and Analysis of Protein ISGylation.- Analysis of sion Theory; Environmental Management; Organi- Methylation, [..] zation/Planning; Methodology of the Social Sciences Fields of interest Target groups Proteomics; Cell Biology; Pharmacology/Toxicology Researchers and advanced students specialising in management and planning issues relating to forestry Target groups and natural resource management, mostly in Researchers studying protein structure-function and Europe, North America, Australia/New Zealand, al- proteomics, pharmaceutical scientists, cell biologists so in Latin America (e.g. Brasil and Chile), in Fin- land specifically, both at the University of Joensuu Type of publication and at the University of Helsinki, courses will be Contributed volume given that intend to use this book as a textbook. Due May 2008

Type of publication 2008. Approx. 490 p. 128 illus. (Methods in Molecular Biology, Graduate/advanced undergraduate textbook Vol. 446) Hardcover

Due February 2008 79,95 € ISBN 978-1-58829-719-8

2008. Approx. 250 p. (Managing Forest Ecosystems, Vol. 16) Hardcover

85,00 € ISBN 978-1-4020-6786-0 springer.com/booksellers Life Science 69

V.J. Karplus, National Institute of Biological Sciences, Beijing, Chi- N. Kato, Osaka University, Japan; S. Kamimura, The University of J.M. Keith, University of Queensland, St. Lucia, QLD, Australia na; X.W. Deng, Yale University, New Haven, CT, USA Tokyo, Japan (Eds.) (Ed.)

Agricultural Biotechnology in China Bio-mechanisms of Swimming and Bioinformatics

Origins and Prospects Flying Volume I: Data, Sequence Analysis and Evolution Fluid Dynamics, Biomimetic Robots, and Sports Science

Over the last thirty years, China has developed one Not only is the quantity of life science data expand- of the world’s largest public research programs in ing, but new types of biological data continue to Biomechanics studies of animals in swimming and agricultural biotechnology. Building on a long tradi- be introduced as a result of technological develop- flying can serve an increasing role in understanding tion of agricultural advances, Chinese scientists have ment and a growing understanding of biological the mechanisms that enable animals to move effec- applied biotechnology techniques to develop hun- systems. Methods for analyzing these data tively and efficiently in fluid, as well as analyzing the dreds of novel crop varieties suited to local farming are an increasingly important component of mod- characteristics of their various forms of behavior in conditions and challenges. Agricultural Biotechnol- ern biological research. In Bioinformatics, leading fluid. The rich variety of mechanisms employed by ogy in China: Origins and Prospects is a comprehen- researchers in the field provide a selection swimming and flying organisms has long been an sive examination of how the origins of biotechnol- of the most useful and widely applicable methods, inspiration for engineers and scientists. These areas ogy research agendas, along with the effectiveness able to be applied as is, or with minor variations, of research, which form the basis of this volume, in- of the seed delivery system and biosafety oversight, to many specific problems. Volume I: Data, clude the locomotive mechanisms and behaviors of help to explain current patterns of crop development Sequence Analysis and Evolution examines a selec- animals in swimming and flying ranging from mi- and adoption in China. Based on firsthand insights tion of methods involving the generation and orga- croorganisms to dolphins from the biological aspect, from China’s laboratories and farms, Valerie Karplus nization of data, including sequence data, RNA and hydrodynamics of swimming and flying, biomimet- and Dr. Xing Wang Deng explore the implications protein structures, microarray expression data and ic swimming or flying robots, and sports science. of China’s investment for the nation’s rural develop- functional annotations, methods for discovering the This book follows Bio-mechanisms of Animals in ment, environmental footprint, as well as its global functional components of genomes, whether they be Swimming and Flying published in 2004 including scientific and economic competitiveness. genes, alternative splice sites, non-coding RNAs or 11 chapters. This time, the book includes 31 chapters regulatory motifs, and several of the most interesting on the latest researches into natural autonomous sys- Features methods in phylogenetics and evolution. Focuses in depth on the historical, political, and soci- tems and locomotion in both flying and swimming ological context that led to the development of trans- organisms. The area of sports science such as analy- Features genic crops in China Takes a thorough look at the sis [..] Encompasses topics from across the diverse rationale behind biotechnology development in Chi- field of bioinformatics through its broad scope Features na Evaluates the current and potential prospects of approach Over 80 authors from around the The interesting features of this book are 1) covering biotechnology development to alleviate China’s agri- globe contribute to the two vol- of wide range of animals from flagellated microor- cultural challenges and how the lessons may apply to umes, including many leading experts in their re- ganisms to marine mammals, 2) handling of recent the rest of the world Translation into Chinese [..] spective subjects An inter-disciplinary collaboration new research results on natural autonomous systems involving biologists, biochemists, physicists, mathe- and locomotion mechanisms of animals in swim- Contents maticians, statisticians and computer scientists Con- ming and flying, and 3) development of interdisci- Preface.- Introduction.- From Seeds to tains simplified [..] EmpiresChina’s Long Agricultural History.- Modern plinary discussions between biology and engineering. Science on the Farm The Green Revolution.- Trans- Contents Fields of interest formation in China’s Agriculture in the Twentieth Managing Sequence Data.- RNA Structure Deter- Bioinformatics; Biophysics; Artificial Intelligence Century.- Agricultural Biotechnology: New Tools mination by NMR.- Protein Structure Determina- (incl. Robotics); Behavioural Sciences; Biomedical for Ancient Practices.- Agricultural Biotechnology tion by X-ray Crystallography.- Pre-processing of Engineering Takes Root in China.- From Lab to Field.- China’s Microarray Data and Analysis of Differential Expres- First Transgenic Crops.- Biosafety and China’s Regu- Target groups sion.- Developing an Ontology.- Genome Annota- latory Policy.- Looking to the Future: Trends in Plant World wide researchers of biomechanics, hydrody- tion.- Multiple Sequence Alignment.- Finding Genes Sciences and Agricultural Biotechnology Research.- namics, or biomimetic robotics in animal locomo- in Genome Sequence.- Bioinformatics Detection of Conclusion.- Works Cited.- Index. tion or sport sciences. Alternative Splicing.- Reconsruction of full-length isoforms from Splice Graphs.- Sequence Segmenta- Fields of interest Type of publication tion.- Discovering Sequence Motifs.- Modeling Se- Plant Sciences; Agriculture; Biotechnology Proceedings quence Evolution.- Inferring Trees.- Detecting the Presence and Location of Selection in Proteins.- [..] Target groups Due October 2007 Plant scientists focusing on Biotech, Agricultural Sci- Fields of interest ence, technology policy analysts, scholars of Plant Bioinformatics; Computational Biology/Bioinfor- Biotechnology, Agricultural Development and Tech- 2008. Approx. 420 p. 303 illus. 13 in color Hardcover matics; Biochemistry, general; Statistics for Life Sci- nological Innovation, agricultural economists, and ences, Medicine, Health Sciences; Human Genetics the university-educated interested public 124,95 € ISBN 978-4-431-73379-9 Target groups Type of publication Molecular biologists, bioinformaticians, geneticists, Monograph microbiologists, biochemists, plant and agricultural scientists, medical researchers and evolution re- Due December 2007 searchers

Type of publication 2008. Approx. 145 p. Hardcover Contributed volume 79,95 € ISBN 978-0-387-71138-6 Due June 2008

2008. Approx. 505 p. 133 illus. 3 in color (Methods in Molecular Biology, Vol. 452) Hardcover

91,65 € ISBN 978-1-58829-707-5 70 Life Science springer.com/booksellers

J.M. Keith, University of Queensland, St. Lucia, QLD, Australia J.A. Kent, Morgantown, WV, USA (Ed.) (Ed.) 2007. Approx. 1755 p. (in 2 volumes, not available separately) Hardcover Kent and Riegel's Handbook Bioinformatics of Industrial Chemistry and 169,95 € ISBN 978-0-387-27842-1 Volume II: Structure, Function and Applications Biotechnology

Not only is the quantity of life science data expand- Substantially revising and updating the classic ref- ing, but new types of biological data continue to be erence in the field, this handbook offers a valuable introduced as a result of technological development overview and myriad details on current chemical and a growing understanding of biological systems. processes, products, and practices. No other source Methods for analyzing these data are an increasing- offers as much data on the chemistry, engineering, ly important component of modern biological re- economics, and infrastructure of the industry. The search. In Bioinformatics, leading researchers in Handbook serves a spectrum of individuals, from the field provide a selection of the most use- those who are directly involved in the chemical in- ful and widely applicable methods, able to be ap- dustry to others in related industries and activities. plied as is, or with minor variations, to many spe- It provides not only the underlying science and tech- cific problems. Volume II: Structure, Func- nology for important industry sectors (30 of the tion and Applications contains methods pertinent book’s 38 chapters), but also broad coverage of criti- to the prediction of protein and RNA structures and cal supporting topics. Industrial processes and prod- the analysis and classification of structures, methods ucts can be much enhanced through observing the for inferring the function of previously identified ge- tenets and applying the methodologies found in new nomic elements, chiefly protein-coding genes, med- chapters on Green Engineering and Chemistry, Prac- ical applications in diagnostics and drug discovery, tical Catalysis, and Environmental Measurements; as and "meta-methods" for developers of bioinformatics well as expanded treatment of Safety and Emergen- algorithms. cy Preparedness. Understanding these factors allows Features them to be part of the total process and helps [..] Encompasses topics from across the diverse Features field of bioinformatics through its broad scope Provides an integrated view of manufacturing ar- approach Over 80 authors from around the eas with other topics essential in the new era. Chap- globe contribute to the two vol- ters new to this edition: history of the chemical in- umes, including many leading experts in their re- dustry, green engineering, environmental consider- spective subjects An inter-disciplinary collaboration ations, nanotechnology, the nuclear industry, indus- involving biologists, biochemists, physicists, mathe- trial catalysis, industrial enzymes and biocatalysis, maticians, statisticians and computer scientists Con- industrial biotechnology, industrial production of tains simplified [..] therapeutic proteins, biomass utilization Contents Contents UNAFold: Software for Nucleic Acid Folding and Historical Development of the Chemical Industry.- Hybridization.- Protein Structure Prediction.- An Economic Aspects of the Chemical Industry.- Chem- Introduction to Protein Contact Prediction.- Analy- ical Process Safety: Safe Practices and Accident Pre- sis of Mass Spectrometry Data in Proteomics.- The vention.- Managing an Emergency Preparedness Classification of Protein Domains.- Inferring Func- Program.- Applied Statistical Methods.- Green En- tion from Homology.- The Rosetta Stone Method.- gineering: Integration of Green Chemistry, Pollu- Inferring Functional Relationships from Conserva- tion Prevention, and Risk Based Considerations.- In- tion of Gene Order.- Phylogenetic Profiling.- Phylo- dustrial Catalysis, a Practical Guide.- Environmental genetic Shadowing: Sequence Comparisons of Mul- Chemical Determinations.- Nanotechnology: Prin- tiple Primate Species.- Prediction of Regulatory El- ciples and Applications .- Synthetic Organic Chem- ements.- Expression and Microarrays.- Identifying icals.- Chemistry in the Pharmaceutical Industry.- Components of Complexes.- Integrating Functional Manufactured Textile Fibers.- Dye Application, [..] [..] Fields of interest Fields of interest Process and Chemical Engineering; Biotechnology; Bioinformatics; Computational Biology/Bioinfor- Industrial Pollution Prevention; Industrial and Pro- matics; Biochemistry, general; Statistics for Life Sci- duction Engineering; Quality Control, Reliability, ences, Medicine, Health Sciences; Human Genetics Safety and Risk; Polymer Sciences Target groups Target groups Molecular biologists, bioinformaticians, geneticists, Chemical manufacturing operations personnel (pres- microbiologists, biochemists, plant and agricultur- ident to plant manager); manufacturing, process su- al scientists, medical researchers and evolution re- pervision, or process development personnel; those searchers working in areas which touch upon environmental, Type of publication safety, and other aspects of the chemical industry; Contributed volume teachers of chemical engineering design; upper division chemical engineering students; those who regulate or report on the chemical industry; university Due June 2008 and public libraries

2008. Approx. 470 p. 117 illus. 3 in color (Methods in Molecular Type of publication Biology, Vol. 453) Hardcover Handbook

91,65 € Due November 2007 ISBN 978-1-60327-428-9 springer.com/booksellers Life Science 71

B.M. Kessler, Oxford University, Oxford, UK (Ed.) M.T.H. Khan, University of Tromso, Norway (Ed.) M.T.H. Khan, University of Tromso, Norway (Ed.)

Activity-based Chemical Proteomics Bioactive Heterocycles III Bioactive Heterocycles V

This book focuses on applications of functional proteomics methods to report on the activity Features Features of biomolecules with the use of chemical tools if Heterocyclic chemistry is the biggest branch of Heterocyclic chemistry is the biggest branch of applicable. This includes the use of mecha- chemistry covering two-third of the chemical litera- chemistry covering two-third of the chemical litera- nism-based probes specific for enzyme classes (e.g. ture The series covers hot topics of frontier research ture The series covers hot topics of frontier research proteases), but also the measurement of protein summarized by reputed scientists in the field Our re- summarized by reputed scientists in the field Our re- interaction kinetics with ligands and small com- view series is topic related Online version available view series is topic related Online version available pounds, and monitoring enzyme-substrate kinetics on SpringerLink.com on SpringerLink.com and posttranslational modifications (phosphorylation, methylation, acetylation, ubiquitylation). Contents Contents A.-M. Rydén, O. Kayser: Chemistry, Biosynthesis N. Saracoglu: Functionalization of Indole and Fields of interest and Biological Activity of Artemisinin and Related Pyrrole Cores via Michael Type Additions.- J. C. Proteomics Natural Peroxides.- M.T.H. Khan: Sugar-derived Menéndez: Chemistry of the Welwitindolinones.- G. Heterocycles and Their Precursors as Inhibitors Topcu, O. Demirkiran: Lignans from Taxus Species.- Type of publication Against Glycogen Phosphorylases (GP).- R.P. Ver- S. Süzen: Antioxidant Activities of Synthetic Indole Contributed volume ma: Cytotoxicity of Heterocyclic Compounds against Derivatives and Possible Activity Mechanisms.- M. Various Cancer Cells: A Quantitative Structure-Ac- González, H. Cerecetto, A. Monge: Quinoxaline 1,4- Due February 2009 tivity Relationship Study.- M. Alamgir, D.St.C. Black, dioxide and Phenazine 5,10-dioxide Chemistry and N. Kumar: Synthesis, Reactivity and Biological Activ- Biology.- M.T.H. Khan: Quinoline Analogues as An- ity of Benzimidazoles.- M.T.H. Khan: Heterocyclic ti-angiogenic Agents and Telomerase Inhibitors.- Y. 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Compounds against the Enzyme Tyrosinase Essen- Liu, S. Zhang, J.H. Jung, T. Xu: Bioactive Furanoses- entry 2209) Hardcover tial for the Melanin Production – Biochemical [..] terterpenoids from Marine Sponge.- C.A. [..] 76,65 € Fields of interest Fields of interest ISBN 978-1-60327-311-4 Organic Chemistry; Biochemistry, general; Medici- Organic Chemistry; Biochemistry, general; Medici- nal Chemistry nal Chemistry

Target groups Target groups Scientists and practitioners in the mentioned fields Scientists and practitioners in the mentioned fields and in industry and in industry

Type of publication Type of publication Reviews Reviews

Due October 2007 Due October 2007

2007. XVI, 287 p. Also available online. (Topics in Heterocyclic 2007. XVI, 335 p. Also available online. (Topics in Heterocyclic Chemistry, Vol. 9) Hardcover Chemistry, Vol. 11) Hardcover

189,95 € 219,00 € ISBN 978-3-540-73401-7 ISBN 978-3-540-73405-5 72 Life Science springer.com/booksellers

M.T.H. Khan, University of Tromso, Norway (Ed.) R. Khosravi-Far, Harvard Medical School, Boston, MA, USA; E. K.-J. Kim, University of Soutern California, Los Angeles, CA, USA; White, Rutgers University, Piscataway, NJ, USA (Eds.) C. Ehrhardt, University Dublin Trinity College, Dublin, Ireland (Eds.) Bioactive Heterocycles IV Programmed Cell Death in Cancer Progression and Therapy Drug Absorption Studies In Situ, In Vitro and In Silico Models Features Heterocyclic chemistry is the biggest branch of Programmed cell death (PCD) plays pivotal roles chemistry covering two-third of the chemical litera- in tumor progression, cancer therapeutics and re- In the last 15 years, a great number of cell- or tis- ture The series covers hot topics of frontier research sistance of tumor cells to therapy. With the discov- sue-based in vitro models have been introduced into summarized by reputed scientists in the field Our re- ery of key mechanisms that are involved in medi- the biopharmaceutics arena. These models mimic the view series is topic related Online version available ating PCD and in promoting resistance to therapy, different biological barriers that a drug has to over- on SpringerLink.com design of therapeutic approaches for promoting tu- come to finally reach its target organ/cell/receptor. Contents mor-selective cell death has risen dramatically. With These in vitro models have been found very useful in T. Flemming, R. Muntendam, C. Steup, O. Kayser: this book, we give a comprehensive overview of the not only characterising the permeability behaviour of Chemistry and Biological Activity of Tetrahydro- mechanisms that are involved in mediating and reg- drugs molecules in epithelial and endothelial tissues, cannabinol and its Derivatives.- C. Hansch, R.P. Ver- ulating PCD in cancer. We also provide a detailed in- but also studying drug delivery systems for improved ma: Quantitative Structure-Activity Relationships dication of the utility of PCD in cancer therapy. This delivery and enhanced absorption. Compared to the of Heterocyclic Topoisomerase I and II Inhibitors.- book will be a valuable resource for researchers in- complex in vivo situation, in vitro models offer a M.T.H. Khan: Molecular Modeling of the Biologi- vestigating the role of PCD in cancer and other dis- fast, convenient approach with cost advantages most cally Active Alkaloids – A Critical Review.- M.T.H. eases, researchers investigating the molecular mech- of times. Most importantly, they can be standard- Khan, A. Ather: Microbial Transformation of Ni- anism of chemotherapeutic agents and drug-resis- ised and automatised to be applicable to the high- trogenous Compounds – An Update.- N. Hamdi, tance in cancer and for physicians using chemother- throughput screening. Starting at the molecular lev- P.H. Dixneuf: Synthesis of Triazoles and Coumarins apeutic agents. Additionally, this book will be a im- el of studies, continuing with cell monolayer models Compounds and Their Physiological Activity.- M. portant educational source for PhD students special- (both primary and cell lines) and in situ techniques Maiti, G.S. Kumar: Protoberberine Alkaloids: [..] izing in cell biology, immunology and MD students as a final testing format, the book provides a practi- interested in Oncology and Cancer Therapeutics. cal approach to contemporary in vitro techniques for Fields of interest drug absorption [..] Organic Chemistry; Biochemistry, general; Medici- Features nal Chemistry Up-to-date and comprehensive description of Features Molecular Mechanism of PCD in Cancer Progres- Comprehensively summarises the different ap- Target groups sion and Therapy Up-to-date and comprehensive in- proaches to assess drug absorption from in vitro Scientists and practitioners in the mentioned fields formation regarding the current therapeutic strate- models Gives a review on the current state-of-the-art and in industry gies that utilize PCD Detailed indication of the utili- in pharmaceutical cell biology Provides readers with ty of PCD in future cancer therapy Chapters on the helpful protocols for many applications that can be Type of publication current and future of RNA interference in therapeu- directly used at the laboratory bench Reviews tics and Pathways involved in Stem Cell Survival and Death Contents Perfused Organ Level/In Situ Techniques.- Models Due October 2007 Fields of interest for skin absorption and skin toxicity testing.- Mod- Cancer Research; Cell Biology; Molecular Medicine; els of the small intestine.- Drug absorption from the 2007. XVI, 317 p. (Also available online) (Topics in Heterocyclic Immunology; Oncology colon in situ.- In vivo and ex vivo models for assess- Chemistry, Vol. 10) Hardcover ing drug delivery across the buccal mucosa.- In situ Target groups and ex vivo nasal models for preclinical drug devel- 209,00 € Academic and industrial researchers investigating opment studies.- The isolated perfused lung for drug ISBN 978-3-540-73403-1 the role of PCD in cancer and other diseases (post- absorption studies.- Cellular Level – In Vitro Models doctoral fellows, Ph.D. students and technicians), of Epithelial and Endothelial Barriers.- In vitro mod- researchers investigating the molecular mechanism els for investigations of buccal drug permeation and of chemotherapeutic agents, researchers investi- metabolism.- In vitro screening models to assess in- gating drug-resistance in cancer, physicians using testinal drug [..] chemotherapeutic agents (majority of which induce apoptosis), PhD students specializing in cell biology, Fields of interest immunology, MD students interested in Oncology Pharmacology/Toxicology; Biotechnology; Cell Biol- and Cancer Therapeutics, Libraries at [..] ogy; Medicine, general

Type of publication Target groups Contributed volume Researchers and scientists/professionals in the fields of pharmaceutical sciences, biotechnology, cell biolo- Due October 2007 gy, and medicine Type of publication 2007. Approx. 480 p. (Advances in Experimental Medicine and Contributed volume Biology, Vol. 615) Hardcover

119,95 € Due February 2008 ISBN 978-1-4020-6553-8 2008. Approx. 600 p. (Biotechnology: Pharmaceutical Aspects, VII) Hardcover

124,95 € ISBN 978-0-387-74900-6 springer.com/booksellers Life Science 73

G. Klein, P. Becker, Usingern, Germany C. Knappett, University of Exeter, UK; L. Malafouris, Cambridge K. Knödel, Bundesanstalt für Geowissenschaften und Rohstoffe, University, Cambridge, UK (Eds.) Berlin, Germany; G. Lange, Bundesanstalt für Geowissenschaften und Rohstoffe, Berlin, Germany; H.-J. Voigt, Brandenburgische Farewell to the Internal Clock Technische Universität Cottbus, Germany; Bundesanstalt für Ge- Material Agency owissenschaften und, Hannover, Germany (Ed.) A contribution in the field of chronobiology Towards a Non-Anthropocentric Approach Environmental Geology

"This book is not a contribution to the numerous su- Handbook of Field Methods and Case Studies perstitious beliefs relating to the moon. Rather, the The idea of an "agent" in the social sciences connotes following will demonstrate and above all prove by a person or persons whose motivation, intentions or means of experiments which can be reproduced at goals bring about change. Along with this, agency is This handbook describes a broad spectrum of meth- any time that the moon does in fact influence certain believed to be a uniquely human attribute. This be- ods in the fields of remote sensing, geophysics, ge- biological rhythms, evoking them and determining lief comes from a deeply entrenched assumption that ology, hydrogeology, geochemistry, and microbiol- their timing." So begins Gunter Klein's exploration agency is a property, attribute or capacity processed ogy designed to investigate landfill, mining and in- of the notion of internal clocks. With the fresh per- solely by human entities, be they individual or col- dustrial sites. The descriptions provide information spective of a curious and insightful non-scientist, Mr. lective. The corollary is that no human entities are about the principle of the methods, applications, fun- Klein examines the question of what force, time or deemed to be devoid of agency – although they may damentals, instruments, survey practice, processing tide, actually provides more influence over cellular often be entangled in human actions, they never have and interpretation of the data, quality assurance, per- biomechanics. Readers may agree or disagree with the initiative and thus play a purely secondary role. sonnel, equipment, time needed, examples, as well as his hypothesis, but Mr. Klein's provocative outlook is In this volume, the editors are challenging this posi- references and sources for further reading. Further- sure to engage the mind and encourage discussion. tion and examine the possibility that agency is not a more, this handbook deals with the stepwise proce- solely human property. Instead, this collection of ar- dure for investigating sites and common problems Features chaeologists, anthropologists, sociologists and other faced in efficient implementation of field operations. With the fresh perspective of a curious and insight- social scientists explore the symbiotic relationships It can be used as a practical guide for training stu- ful non-scientist, Mr. Klein examines the question of between humans and material entities (a key opening dents, as well as to illustrate the advantages of inter- what force, time or tide, actually provides more in- a door, a speed bump raising a car) as they engage disciplinary site investigations to decision-makers fluence over cellular biomechanics with one another co-dependently. Such an approach faced with their own environmental investigations. has important [..] Contents Features In the Beginning was the Leaf.- Chronobiology To- Features Fundamentals, applications, and limits of methods day.- The Moon and Chronobiology.- Location and The theory of agency is an important one in the so- International case studies Many illustrations in color Mode of Operation of the "Internal Clock".- The cial sciences and has always been assumed to be an- Mistake Concerning the Internal Clock of the Bean.- thropocentric. This collection of archaeologists, an- Contents Does the Lunar Clock Also Tick for Animals and thropologists, sociologists and other social scien- Introduction.- Preparatory Steps and Common Human Beings?- Appendix: Experimental Proce- tists use their understanding of agency to demon- Problems.- Remote Sensing.- Photogramme- dures.- Appendix: Support Data.- References. strate that material culture or non-human entities al- try.- Nonphotographic Imaging from Aircraft and so have agency. Fields of interest Space-borne Platforms.- Geophysics.- Geological, Hydrogeological, Geochemical and Microbiological Life Sciences, general; Cell Biology; Biomedicine Contents Investigations.- Integration of Investigation Results.- general; Neurosciences; Behavioural Sciences; Popu- Introduction: Agency and Material Culture.- The Glossary.- Subject Index. lar Science in Nature and Environment Argument for Material Agency .- Where Brain, Body and World Collide.- Structural Memory, Target groups Fields of interest Distributed Cognition, and Material Agency.- Applied Geosciences; Microbiology; Soil Science Scientists, graduate students, upper-level undergrad- Conversations with Material Agency: Gordon uate students & Conservation; Geochemistry; Hydrogeology; Pask’s Cybernetic Machines.- Agent-Artefact Space.- Geotechnical Engineering The Agency of Tools.- Engagement Theory Type of publication (and the pitfalls of ‘agency’).- The Neglected Net- Monograph Target groups works of Agency.- Seeing Through Sensitive Stone.- Libraries; scientists, researchers, consultants, profes- In Context: Archaeological Recording and the sionals, graduates Due October 2007 Actions of Form.- Concluding Remarks Type of publication Fields of interest 2007. XXIV, 116 p. 13 illus. Hardcover Handbook Archaeology; Anthropology; Cultural Heritage 34,95 € Due November 2007 ISBN 978-0-387-40315-1 Target groups This truly an interdisciplinary work. The primary audience is archaeologists and the area of material 2008. XXVI, 1358 p., 501 illus., 243 in colour, 204 Tables Hardcov- culture in particular. It will demonstrate to this au- er dience how a larger social science theory and debate can be brought to their specific disciplines. Addition- 199,95 € ally, the editors include specifics about courses in ISBN 978-3-540-74669-0 Europe and the U.S. that would be interested in this book.

Type of publication Contributed volume

Due May 2008

2007. Approx. 250 p. Hardcover

57,75 € ISBN 978-0-387-74710-1 74 Life Science springer.com/booksellers

B. Kobe, University of Queensland, Brisbane, Australia; M. Guss, A. Kranz, University of Natural Resources and Applied Life Sci- R. Krishna, Merck & Co., Inc., Rahway, NJ, USA; L. Yu, Center for University of Sydney, Sydney, Australia; Th. Huber, University of ences, Vienna, Austria; R.A. Klenke, UFZ, Halle, Germany; I. Ring, Drug Evaluation & Research, Rockville, MD, USA (Eds.) Queensland, Brisbane, Australia (Eds.) UFZ, Halle, Germany; F. Rauschmayer, UFZ, Halle, Germany; K. Henle, UFZ, Halle, Germany (Eds.) Biopharmaceutics Applications in Structural Proteomics Human Wildlife Conflicts in Europe Drug Development High-Throughput Methods Fisheries and Fish-eating Vertebrates as a Model Case Drug performance is a vital aspect of new drug de- The objective of this volume of Methods in Molecu- velopment as it draws on interdisciplinary exper- lar Biology on Structural Proteomics: High-through- This book is about conflicts between different stake- tise from both pharmaceutics and pharmacokinet- put methods is to provide readers with a current holder groups triggered by protected species that ics disciplines. It is at the key interface that the dis- view of all aspects of the 'pipeline' that takes protein compete with humans for natural resources. It cipline of biopharmaceutics has emerged. The past targets to structures and how these have been opti- presents key ecological features of typical conflict two decades have witnessed considerable advances mised. This volume includes chapters describing, species and mitigation strategies including technical in biopharmaceutics, particularly with regard to in-depth, the individual steps in the Structural Ge- mitigation and the design of participatory decision bioavailability/bioequivalence, product quality and nomics pipeline, as well as less detailed overviews of strategies involving relevant stakeholders. The book regulatory standards of approval. Biopharmaceutics individual Structural Genomics initiatives. The read- provides not only a European perspective covering Applications in Drug Development presents readers are encouraged to access further details on the case studies from various European countries, but it ers with step-wise, detail-conscious information to methodologies in on-line resources such as PepcDB also develops a framework for the development of develop quality pharmaceuticals. It is composed of (Protein expression purification and crystallization biodiversity conflict reconciliation action plans that carefully crafted sections introducing key concepts database; pepcdb.pdb.org) and in the cited literature. can be used globally. and advances in the areas of dissolution, BA/BE, We emphasize that most methods are as amenable BCS, IVIC, and product quality, with specific focus to small laboratories as to large consortia, and do not Features on integration of regulatory considerations and case require major investments in facilities; we hope that The book presents a structured procedure covering histories highlighting the biopharmaceutics strate- this volume will help smaller laboratories establish ecological and legal, economic, and social aspects of gies adopted in development of successful drugs. some of the high-throughput techniques. the wildlife conflicts Features Features Fields of interest discusses state of the art knowledge in biopharma- First book of protocols to cover techniques in a new Biogeosciences; Nature Conservation; Environmen- ceutics identifies key issues and opportunities in a and emerging field Offers step by step methods and tal Management; Environmental Law distinct problem-solving approach protocols for reproducible lab experiments Each Target groups protocol has a Notes section where the major re- Contents Researchers and decision makers in the fields of na- searchers in the field offer tricks and hints of the Introduction To Biopharmaceutics And Its Role In ture conservation and environmental management trade Drug Development.- Molecular and Physicochemi- cal Properties Impacting Oral Absorption of Drugs.- Type of publication Contents Dissolution Testing.- Drug Absorption Principles.- Monograph Target selection for structural genomics: An Current Industrial Practices of Evaluating Perme- Overview.- A General target selection method for ability/Absorption and P-glycoprotein Interaction.- crystallographic proteomics.- Target Selection: Due November 2007 Excipients As Absorption Enhancers.- Intestinal Triage in the Structural Genomics Battlefield.- Data Transporters In Drug Absorption.- Bioavailability Management in Structural Genomics: An Overview.- 2007. Approx. 300 p. 50 illus. (Environmental Science) Hardcover And Bioequivalence.- A Biopharmaceutical Classifi- Data deposition and annotation at the Worldwide cation System Approach to Dissolution: Mechanisms Protein Data Bank.- Prediction of protein disorder.- 99,95 € and Strategies.- Food Effects On Drug Bioavailabili- Protein domain prediction.- Protein Structure Mod- ISBN 978-3-540-34788-0 ty: Implications For New And Generic Drug [..] eling With MODELLER.- High throughput cloning with restriction enzymes.- Automated recombinant Fields of interest protein expression screening in Escherichia coli.- Pharmacology/Toxicology; Biochemistry, general From no expression to high-level soluble expression [..] Target groups Hospital and clinical pharmacists; people in the Fields of interest pharmaceutical industry; grad and advanced under- Proteomics; Microbial Genetics and Genomics; graduate students in pharmacy, pharmacology, and Bioinformatics; Cell Biology allied health professions; regulatory professionals who frequently interact with biopharmaceutics sci- Target groups entists Structural biologists and molecular biologists Type of publication Type of publication Reference work Contributed volume Due December 2007 Due February 2008 2008. Approx. 470 p. Hardcover 2008. Approx. 400 p. 120 illus. 10 in color (Methods in Molecular Biology, Vol. 426) Hardcover 124,95 € ISBN 978-0-387-72378-5 76,95 € ISBN 978-1-58829-809-6 springer.com/booksellers Life Science 75

A. Kukol (Ed.)

Molecular Modeling of Proteins

Molecular modeling has undergone a remarkable transformation in the last 20 years, as biomolecular simulation moves from the realm of specialists to the wider academic community. Molecular Mod- eling of Proteins provides thorough introductions and a compilation of step-by-step methods applicable to problems faced by non-specialists – especially those new to the software packages used in molecular modeling. Tips on troubleshooting and avoiding common pitfalls are included in this book, along with chapters covering a wide range of subjects ranging from free energy calculation to applications for drug design. Written by an internationally distinguished panel of investigators and outlining the most striking developments in the field, Molecular Model- ing of Proteins is an invaluable resource for those in the industry, as well as a cutting-edge reference for students and professionals in the fields of chemistry, biochemistry, biology, biophysics and bioinformatics.

Features - Provides step-by-step reproducible laboratory experiments presented by world renowned experts in the field - Covers the transformation of the field from highly specialized to the wider academic community - Examines in-depth the software packages used in molecular modeling

Contents Molecular dynamics simulations.- Monte Carlo simulations.- Hybrid quantum and classical methods for computing kinetic isotope effects of chemical reactions in solutions and in enzymes.- Comparison of forcefields for molecular dynamics simulations.- Normal modes and essential dynamics.- Free energy calculations.- Calcu- lation of absolute protein-ligand binding constants with the molelcular dynamics free energy perturba- tion method.- Free energy calculations applied to membrane proteins.- Molecular dynamics simulations of membrane proteins.- Membrane associated proteins and [..]

Fields of interest Biochemistry, general; Proteomics; Molecular Medicine; Bioinformatics

Target groups Chemists, biochemists, biologists, biophysicists, bioinformatics scientists.

Type of publication Contributed volume

Due May 2008

2008. Approx.320 p (Methods in Molecular Biology, Vol. 443) Hardcover

79,95 € ISBN 978-1-58829-864-5 springer.com/booksellers Life Science 76

A. Kumar, Lund University, Sweden; I.Y. Galaev, Lund University, V.F. La Russa, Tulane University Medical School, New Orleans, J. Lafond, University of Quebec at Montreal, QC, Canada; C. Vail- Sweden; B. Mattiasson, Lund University, Sweden (Eds.) LA, USA; P.J. Quesenberry, Rhode Island Hospital, Providence, RI, lancourt, INRS-Institut Armand-Frappier, Pointe-Claire, QC, Cana- USA (Eds.) da (Eds.) Cell Separation Stem Cells Human Embryogenesis Fundamentals, Analytical and Preparative Methods Research Tools and Transplantion

Contents Features Embryo Implantation and Uterine Biology.- Preg- Fields of interest Covers trends in modern biotechnology All aspects nant Uterus.- Placental Development.- Placenta Cell Biology of this interdisciplinary technology, where knowl- Transfer.- Cardiovascular and Circulatory Systems.- edge, methods and expertise are required from Nervous System.- Gastrointestinal System.- Male chemistry, biochemistry, microbiology, genetics, Type of publication Contributed volume Urogenital and Reproductive System.- Female Uro- chemical engineering and computer science, are genital and Reproductive System.- Immune System.- treated More information as well as the electronic Embryo Morphogenesis: Body Architecture Set Up.- version available at springer.com Due November 2008 Endocrinology of Embryogenesis.- Steroidogene- sis.- Signals Transmission in Utero.- Human Embry- Contents 2009. Approx. 450 p. (Methods in Molecular Biology, Preliminary onic Stem Cells.- Fetal Programming.- Epigenetic: M. B. Dainiak, A. Kumar, I.Y. Galaev, B. Mattiasson: entry 2147) Hardcover How "Nuture" Alters "Nature".- Teratology.- Animal Methods in Cell Separations.- S.F. Ibrahim, G. van Cloning by Nuclear Transfer.- Fertilisation in Vitro.- den Engh: Flow Cytometry and Cell Sorting.- A.A. 99,95 € [..] Neurauter, M. Bonyhadi, E. Lien, L. Nøkleby, E. Ru- ISBN 978-1-58829-376-3 ud, S. Camacho, T. Aarvak: Cell Isolation and Ex- Fields of interest pansion Using Dynabeads®.- J. Hubble: Affinity Ad- Cell Biology sorption of Cells to Surfaces and Strategies for Cell Detachment.- M.B. Dainiak, I.Y. Galaev, A. Kumar, Type of publication F.M. Plieva, B. Mattiasson: Chromatography of Liv- Contributed volume ing Cells Using Supermacroporous Hydrogels, Cryo- gels.- R.E. Nordon, S. Craig: Hollow-Fibre Affinity Due January 2009 Cell Separation.- J.M.S. Cabral: [..]

Fields of interest 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Biotechnology; Cell Biology; Analytical Chemistry entry 2212) Hardcover

Target groups 76,65 € Libraries and scientists in biomedicine, biotechnol- ISBN 978-1-60327-008-3 ogy, biochemical/chemical engineering and applied microbiology, university institutes, research groups in industry

Type of publication Reviews

Due November 2007

2008. XIV, 203 p. Also available online. (Advances in Biochemical Engineering / Biotechnology, Vol. 106) Hardcover

149,95 € ISBN 978-3-540-75262-2 springer.com/booksellers Life Science 77

J.R. Lakowicz, University of Maryland Biotechnology Institute, B. Larijani, London Research Institute (Ed.) J. LeDoux, Georgia Inst. of Technology and Emory University (Ed.) Baltimore, MD, USA; C.D. Geddes, University of Maryland Biotech- nology Institute, Baltimore, MD, USA (Eds.) Lipid Signaling Protocols Gene Therapy Protocols

Green Fluorescent Protein Volume 1: Production and In Vivo Applications of Gene Trans- fer Vectors

Fields of interest In the last few years, green fluorescent protein (GFP) Cell Biology has become one of the most widely used tools in In Gene Therapy Protocols, Volumes 1 & 2, in- molecular genetics. The fact that GFP can generate Type of publication ternationally recognized investigators describe cut- an internal highly visible fluorophore has made it Contributed volume ting-edge laboratory techniques for the study of Pro- a tremendously valuable marker or reporter gene duction and In Vivo Applications of Gene Transfer Vectors (Volume 1) and Design and Characteriza- which can be utilised in virtually every field of Due September 2008 molecular cell genetics One of the problems associat- tion of Gene Transfer Vectors (Volume 2). The field ed with this method is how to confirm that the gene of gene therapy has undergone remarkable advances, of interest is being either expressed or activated in 2008. (Methods in Molecular Biology, Preliminary entry 2087) promising to impact human healthcare significantly Hardcover the target cells and to what extent this activation or in the twenty-first century. Today’s technologies can deliver genetic material safely and effectively to cells expression occurs. The use of conventional reporter 74,95 € to slow or halt the progression of disease, and to help genes such as luciferase or lacZ require that the cells ISBN 978-1-58829-727-3 be processed and/or treated with substrates in order repair or regenerate damaged or lost tissues. In this to monitor the reporter gene. The fact that GFP re- first volume of Gene Therapy Protocols: Production quires no additional substrates and can therefore be and In Vivo Applications of Gene Transfer Vectors, montiored non-invasively in living cells has been a readers will find a comprehensive resource of cur- revolutionary advance. In addition, a number of mu- rent and emerging methods for the production of vi- tations in the wild type GFP protein, mean that it can ral and non-viral gene transfer vectors, as well as de- also be used as a quantitative marker in living cells. tailed protocols for critical applications in stem cell GFP can also be used [..] biology, cancer, diabetes, HIV and tissue engineering. This first volume of the [..] Features The discovery of GFP's molecular details, and its Features subesquent utility as one of the most widely used Collects time tested, reproducible laboratory proto- marker/reports tools in molecular genetics, was pop- cols, including tricks and hints, written by experts in ularized in 1996 by the laboratory of Roger Tsien, the field Covers current and emerging methods for PhD, Howard Hughes Medical Institute, University production of viral and non-viral gene transfer vec- of California at San Diego. Dr. Tsien will be writing tors Provides detailed protocols for applications in an introduction and a chapter in this timely volume.. stem cell biology, cancer research and infectious disease Contents - Introduction –Cell pharmacology using GFP -GFP Contents engineered proteins -GFP to study protein interac- Preparation and Quantification of Pseudotyped tions -In vivo imaging with GFP -GFP to study TNF Retroviral Vector.- Production of Retroviral Vec- and its receptors -Enhanced Optical Signals from tors for Clinical Use.- Methods for the Production Native Crystals -GFP & Gene Engineering of Helper-Dependent Adenoviral Vectors.- Methods for the Production of First Generation Adenoviral Fields of interest Vectors.- Large Scale Production of Recombinant Biophysics; Biomedical Engineering; Analytical Adeno-Associated Vectors.- Construction and Pro- Chemistry; Biotechnology; Biochemistry, general duction of Recombinant Herpes Simplex Virus Vec- tors.- Plasmid-based Gene Transfer in Mouse Skele- Target groups tal Muscle by Electroporation.- Chitosan Nanoparti- Researchers in biophysics, biochemistry, bioengi- cle–Mediated Gene Transfer.- PEG-PEI Copolymers neering, biology and medicine. for Oligonucleotide Delivery to Cells and Tissues.- [..] Type of publication Contributed volume Fields of interest Human Genetics; Cell Biology; Infectious Diseases; Due November 2007 Molecular Medicine Target groups 2007. Approx. 320 p. Mit CD-ROM. (Topics in Fluorescence Spec- Geneticists, biologists, stem cell researchers, clinical troscopy, Vol. 12) Hardcover researchers, graduate students, postdoctoral fellows 119,95 € Type of publication ISBN 978-0-387-29343-1 Contributed volume

Due April 2008

2008. Approx. 463 p. 74 illus. 2 in color (Methods in Molecular Biology, Vol. 433) Hardcover

79,95 € ISBN 978-1-58829-903-1 78 Life Science springer.com/booksellers

J. LeDoux, Georgia Institute of Technology and Emory University, W.R. Leifert, CSIRO Human Nutrition, Adelaide, SA, Australia (Ed.) P. Lemanceau, P. Bakker, J. Raaijmakers, G. Bloemberg, M. Höfte, Atlanta, GA, USA (Ed.) M. Cooke (Eds.) G-Protein-Coupled Receptors in Gene Therapy Protocols Drug Discovery New Perspectives and Approaches Volume 2: Design and Characterization of Gene Transfer Vec- in Plant Growth-Promoting tors Rhizobacteria Research The G-protein coupled receptors (GPCRs) and associated peripheral G-proteins underpin a multitude of In Gene Therapy Protocols, Volumes 1 & 2, in- physiological processes. The GPCRs represent one of In the context of increasing international concern ternationally recognized investigators describe cut- the largest super families in the human genome and for food and environmental quality, use of Plant ting-edge laboratory techniques for the study of Pro- are a significant target for pharmaceuticals as well as Growth-Promoting Rhizobacteria (PGPR) for reduc- duction and In Vivo Applications of Gene Transfer bioactive and drug discovery programs. It is estimating chemical inputs in agriculture is a potentially im- Vectors (Volume 1) and Design and Characteriza- ed that greater than 50% of all drugs including those portant issue. PGPR are root-colonizing bacteria that tion of Gene Transfer Vectors (Volume 2). The field in development currently target GPCRs. Indeed, exert beneficial effects on plant growth and develop- of gene therapy has undergone remarkable advances, many of the GPCRs identified have known ligands, ment, but they can be also employed in the control promising to impact human healthcare significant- however, approximately 20% of GPCRs are described of plant pathogens, for enhancing the efficiency of ly in the twenty-first century. Today’s technologies as orphan GPCRs (apparent GPCRs that have a sim- fertilizers, and for degrading xenobiotic compounds. can deliver genetic material safely and effectively to ilar structure to other identified GPCRs but whose This book provides an update by renowned inter- cells to slow or halt the progression of disease, and to endogenous, natural ligand is not known). The gen- national experts on the most recent advances in the help repair or regenerate damaged or lost tissues. In eral aim of this book is to provide researchers with a ecology of these important bacteria, the application this second volume of Gene Therapy Protocols: De- range of protocols that may be useful in their GPCR of innovative methodologies for their study, their in- sign and Characterization of Gene Transfer Vectors, drug discovery programs. It is also the basis or a teraction with the host plant, and their potential ap- readers will find a comprehensive resource of current starting point for the development of future assays in plication in agriculture. Reprinted from European and emerging methods for the processing and char- this field. Therefore, the range of topics covered and Journal of Plant Pathology, Volume 119, No. 3, 2007 acterization of viral and non-viral gene transfer vec- the appropriate methodological approaches in GPCR tors, as well as promising approaches to design vec- drug discovery are reflected in this book. Fields of interest tors for efficient, targeted and regulated gene deliv- Plant Pathology ery and expression. This second [..] Fields of interest Cell Biology; Pharmacology/Toxicology; Biochem- Type of publication Features istry, general; Proteomics; Biotechnology Contributed volume Collects time tested, reproducible laboratory protocols, including tricks and hints, written by experts in Target groups Due November 2007 the field Covers current and emerging methods for Molecular biologists, pharmacologists, biochemists, production of viral and non-viral gene transfer vec- bionanotechnologists tors Provides approaches to design vectors for target- Reprinted from European Journal of Plant Pathology, Volume ed and regularted gene delivery and expression Type of publication 119, No. 2, 2007 Contributed volume Contents 2008. Hardcover Purification of Retrovirus Particles Using Hep- Due September 2009 arin Affinity Chromatography.- Scaleable Purifica- 69,95 € tion of Adenovirus Vectors.- Quantifying the Titer ISBN 978-1-4020-6775-4 and Quality of Adenovirus Stocks.- Chromatogra- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary entry 2245) Hardcover phy-Based Purification of Adeno-Associated Virus.- Spectroscopic Methods for the Physical Characteri- 76,65 € zation and Formulation of Nonviral Gene Delivery ISBN 978-1-60327-316-9 System.- Real Time Multiple Particle Tracking of Gene Nanocarriers in Complex Biological Environ- ments.- Production of Lentiviruses displaying ‘Ear- ly-Acting’ Cytokines for Selective Gene Transfer into Hematopoietic Stem Cells.- Fiber-modified [..]

Fields of interest Human Genetics; Cell Biology; Infectious Diseases; Molecular Medicine

Target groups Geneticists, biologists, gene therapy researchers, basic and clinical researchers, stem cell biologists

Type of publication Contributed volume

Due April 2008

2008. Approx. 379 p. 57 illus. 2 in color (Methods in Molecular Biology, Vol. 434) Hardcover

79,95 € ISBN 978-1-60327-247-6 springer.com/booksellers Life Science 79

P. Lenz, Philipps-Universität Marburg, Germany (Ed.) H.R. Leuchtag M. Lewandowski (Ed.)

Cell Motility Voltage-Sensitive Ion Channels Mouse Molecular Embryology

Biophysics of Molecular Excitability Volume 2

Cell motility is a fascinating example of cell behavior which is fundamentally important to a number Voltage-sensitive ion channels are macromolecules of biological and pathological processes. It is based embedded in the membranes of nerve and muscle Fields of interest on a complex self-organized mechano-chemical ma- fibers of animals. Because of their physiological func- Cell Biology; Developmental Biology chine consisting of cytoskeletal filaments and molec- tions, biochemical structures and electrical switch- ular motors. In general, the cytoskeleton is responsi- ing properties, they are at an intersection of biolo- Type of publication ble for the movement of the entire cell and for move- gy, chemistry and physics. Despite decades of inten- Contributed volume ments within the cell. The main challenge in the field sive research under the traditional approach of gated of cell motility is to develop a complete physical de- structural pores, the relation between the structure of Due February 2009 scription on how and why cells move. For this pur- these molecules and their function remains enigmat- pose new ways of modeling the properties of biologic. This book critically examines physically oriented ical cells have to be found. This long term goal can 2009. Approx. 350 p. (Methods in Molecular Biology, Preliminary approaches not covered in other ion-channel books. only be achieved if new experimental techniques are entry 2242) Hardcover It looks at optical and thermal as well as electrical da- developed to extract physical information from these ta, and at studies in the frequency domain as well as 76,65 € living systems and if theoretical models are found in the time domain. Rather than presenting the read- ISBN 978-1-60327-291-9 which bridge the gap between molecular and meso- er with only an option of mechanistic models at an scopic length scales. Cell Motility gives an authori- inappropriate pseudo-macroscopic scale, it empha- tative overview of the fundamental biological facts, sizes concepts established in organic chemistry and theoretical models, and current experimental devel- condensed state physics. The book’s approach to the opments in this fascinating area. understanding of these unique structures breaks with Features the unproven view of ion [..] Brings together state-of-the art research on cell be- Features havior of fundamental importance to many normal * This book critically examines existing models of biological and pathological processes Presents in- structure--function relations, guided by experimen- terdisciplinary coverage of the field with contribu- tal data and physical principles. * Its coverage uni- tions from biologists and theoretical and experimen- fies topics from electrophysiology, condensed-state tal physicists Discusses a variety of molecular motors physics, polymer chemistry and genetic engineering used by different organisms for movements of the as they bear on the problem of molecular excitabili- cell as a whole and within the cell boundaries ty. * The volume deals with optical, thermal and me- Contents chanical as well as electrical measurements -- in the The Physics Of Listeria Propulsion.- Biophysical As- [..] pects of Actin-Based Cell Motility in Fish Epithelial Fields of interest Keratocytes.- Directed motility and Dictyostelium Biophysics; Animal Physiology; Soft Matter, Com- aggregation.-Microtubule Forces and Organization.- plex Fluids; Animal Biochemistry; Neurobiology Mechanisms of Molecular Motor Action and Inac- tion.- Molecular mechanism of Mycoplasma glid- Target groups ing.- A novel cell motility system.-Hydrody- This book is intended primarily for researchers and namics and rheology of active polar filaments.- Col- students of biophysics. It may also be of interest to lective effects in arrays of cilia and rotational motors. physicists and chemists interested in liquid crystals, biopolymers and membranes sensitive to electric Fields of interest fields, and to theorists interested in solitons and con- Biophysics; Limnology; Cell Biology; Biomedical En- formational transitions in proteins. The target group gineering; Human Physiology is ion channel scientists, particularly those whose Target groups primary focus is on voltage-sensitive ion channels. Researchers in biological physics, graduate students Type of publication in physics and biology Monograph Type of publication Monograph Due October 2007

Due December 2007 2007. Approx. 510 p. Hardcover

174,95 € 2008. Approx. 235 p. 150 illus. (Biological and Medical Physics, Biomedical Engineering) Hardcover ISBN 978-1-4020-5524-9

107,05 € ISBN 978-0-387-73049-3 80 Life Science springer.com/booksellers

M. Lewandowski (Ed.) R. León, Universidad de Huelva, Spain; A. Gaván, Universidad de S. Li, Louisiana State University, Baton Rouge, LA, USA (Ed.) Córdoba, Spain; E. Fernández, Universidad de Córdoba, Spain (Eds.) Mouse Molecular Embryology Electroporation Protocols

Volume 1 Transgenic Microalgae as Green Cell Preclinical and Clinical Gene Medicine Factories

At the time of the lightbulb's invention, not even the Fields of interest most imaginative thinkers could have predicted the Microalgae have been largely cultured and commer- Cell Biology; Developmental Biology prevention and treatment of disease through genes cialized as food and feed additives, and their poten- delivered by electric fields. In Electroporation Pro- tial as source of high-added value compounds is well Type of publication tocols: Preclinicaland Clinical Gene Medicine, top known. But, in contrast to the large number of ge- Contributed volume researchers provide hands-on protocols describing netically modified bacteria, yeast and even higher the process of non-viral delivery of genetic materi- plants, only a few species of microalgae have been Due February 2009 als such as DNA, oligo-DNA, and RNA into target- genetically transformed with efficiency. Initial diffi- ed immune cells, tissues, and model animals in or- culties in the expression of foreign genes in microal- der to better treat disease. Following the successful 2009. Approx. 350 p (Methods in Molecular Biology, Preliminary gae have been progressively overcome, and powerful Methods in Molecular Biology™ series format, each entry 2241) Hardcover molecular tools for their genetic engineering are now method and protocol offers step-by-step, readily re- on hand. A considerable collection of promoters and 76,65 € producible laboratory instructions, with the benefit selectable marker genes and an increasing number of ISBN 978-1-60327-290-2 of several introductory reviews to aid investigators genomic or cDNA sequences have become available new to this exciting technology. in recent years. More work is needed to transform new species of microalgae, specially those that have Features commercial value, so that it would be possible to in- Synthesizes electroporation, electroporation crease the productivity of traditional compounds or chemotherapy, and electroporation gene therapy, synthesize novel ones. Silencing transgenes remains with a focus on the latter Contains step-by-step in- as an important limitation for stable expression of structions that ensure successful results Provides foreign genes. This problem is not [..] notes on troubleshooting and avoiding known pitfalls Features Offers a global view of the genetic manipulation of Fields of interest microalgae and their applications Animal Genetics and Genomics; Cell Biology; Ani- mal Biochemistry; Biotechnology Contents Nuclear Transformation of Eukaryotic Microalgae: Target groups Historial Overview, Achievements and Problems.- Molecular and cellular biologists, veterinarians, ge- Transformation of Cyanobacteria.- Molecular Biol- neticists, biotechnology researchers ogy and the Biotechnological Potential of Diatoms.- Tools and Techniques for Chloroplast Transforma- Type of publication tion of Chlamydomonas.- Influence of Codon Bias Contributed volume on the Expression of Foreign Genes in Microalgae.- In the Grip of Algal Genomics.- Insertional Mutage- Due January 2008 nesis as a Tool to Study Genes/Functions in Chlamy- domonas.- Optimization of Recombinant Protein Expression in the Chloroplasts of Green Algae.- Phy- 2008. Approx. 550 p. 141 illus. 1 in color. (Methods in Molecular coremediation of Heavy Metals using Transgenic [..] Biology, Vol. 423) Hardcover 76,95 € Fields of interest ISBN 978-1-58829-877-5 Cell Biology; Microbial Ecology

Target groups Algologists, biotechnologists, and researchers interested in green cell factories

Type of publication Contributed volume

Due January 2008

2008. Approx. 150 p. (Advances in Experimental Medicine and Biology, Vol. 616) Hardcover

109,95 € ISBN 978-0-387-75531-1 springer.com/booksellers Life Science 81

Y. Li, McMaster University, Hamilton, ON, Canada; Y. Lu, Universi- D.C. Liebler, Vanderbilt University, Nashville, TN D.C. Liebler, Vanderbilt University, Nashville, TN ty of Illinois, Urbana-Champaign, IL, USA (Eds.) Introduction to Proteomics Introduction to Proteomics Functional Nucleic Acids for Analytical Applications Tools for the New Biology Tools for the New Biology

Nature has long used nucleic acid aptamers and en- Fields of interest Fields of interest zymes for regulatory activities, such as the recent- Biochemistry, general Biochemistry, general ly discovered "riboswitches" involved in gene expression. The existence of a large array of natural Type of publication Type of publication and artificial functional nucleic acids has generated Monograph Monograph tremendous enthusiasm and new opportunities for molecular scientists from diverse disciplines to de- Due November 2008 Due November 2008 vise new concepts and real applications that take advantage of those nucleic acids for sensing and other analytical applications. This book provides a time- 2009. Hardcover 2009. Softcover ly and comprehensive overview of recent advances 29,95 € 18,95 € in the field, from leading experts in biology, chem- ISBN 978-1-58829-778-5 ISBN 978-1-58829-896-6 istry, and engineering. A variety of topics are covered, from fundamentals of functional nucleic acids, to their applications as sensors, to nanotechnologies; as well as integration of functional nucleic acids into practical analytical systems.

Features - First in the rapidly emerging field on analytical applications for nucleic acids. - With interdisciplinary approach, a valuable tool for researchers in chemistry, biology, and engineering. - One of the first volumes in comprehensive new Springer series "Inte- grated Microanalytical Sytems," edited by R. Potyrai- lo.

Contents Natural functional nucleic acids: ribozymes, allosteric ribozymes and riboswitches.- Artificial functional nucleic acids: aptamers, ribozymes and deoxyri- bozymes by in vitro selection.- Overview of functional nucleic acids in analytical applications.- Immobi- lization of functional nucleic acids for analytical applications.- Fluorescent aptamer sensors.- Fluores- cent ribozyme and deoxyribozyme sensors.- Colori- metric aptamer sensors.- Fluorescent and colorimet- ric sensors based on functional nucelic acid directed assembly of nanomaterials.- Electrochemical aptamer sensors.- Other aptamer [..]

Fields of interest Analytical Chemistry; Biotechnology; Inorganic Chemistry; Organic Chemistry; Nanotechnology; Materials Science

Target groups Researchers in academic institutions, industrial labs, and government labs; hospital clinicians; agents or inspectors from regulatory agencies such as the U.S. EPA or HUD; graduate or advanced undergraduate students.

Type of publication Monograph

Due November 2007

2007. Approx. 300 p. (Integrated Microanalytical Systems) Hard- cover

62,95 € ISBN 978-0-387-73710-2 82 Life Science springer.com/booksellers

H. Lieth, Institute of Environmental Systems Research, Univer- R.-J. Lin, Beckman Research Institute of the City of Hope, Duarte, S. Lin, Ohio State University, Columbus, OH, USA; H. Zhao, Yale sity of Osnabrueck, Germany; M. García Sucre, IVIC (Instituto USA (Ed.) University, New Haven, CT, USA Venezolano de Investigaciones Científicas Caracas), Caracas, Venezuela; B. Herzog, Justinus-Kerner-Gymnasium, Weinsberg, Germany (Eds.) RNA'Protein Interaction Protocols Handbook on Analyzing Human Genetic Data Mangroves and Halophytes Computational Approaches and Software Restoration and Utilisation Fields of interest Cell Biology The discipline of statistical genetics is highly compu- Type of publication Focusing on Venezuela and Mexico, this edited vol- tational. Be it exact computational methods, simu- Contributed volume ume from the International Society of Halophyte lation based, or a hybrid of the two, computational Utilisation (ISHU) explores the environmental issues packages are indispensable tools and constant com- facing South and Central America's coastal ecosys- Due November 2008 panions of researchers in the field. This handbook tems, and discusses the uses of mangrove species is intended to provide human geneticists and other and other halophytes in addressing issues of both 2009. Approx. 400 p. (Methods in Molecular Biology, Preliminary biomedical researchers with guidance on selections coastal pollution and upland soil salinisation. The entry 2139) Hardcover of appropriate computational methods and software book draws on expertise from Europe and South packages for their specific genetic problems. It may America to present a series of case studies that detail 74,95 € also be used by students and other learners as a refer- Venezuela’s saline ecosystems and examine the eco- ISBN 978-1-58829-419-7 ence in conjunction with a more theoretical and/or nomic potential of mangrove restoration and halo- methodologically oriented text book. This book tries phyte production. It includes cutting-edge research to strike a balance between methodological exposi- into the establishment of new mangrove stands tions and practical guidelines for software selections. which could serve as prototypes for the sustainable Wherever possible, comparisons among competing use of halophytes, including Chenopodium quinoa methods and software are made to highlight the rel- and Tamarix aphylla. Moreover, the detailed exam- ative advantages and disadvantage of the approach- ples from Venezuela and other Caribbean countries es so that the readers can make informed choices to provide useful models for comparison with halo- best match their specific needs. phyte utilisation in other parts of the world – especially the Mediterranean region, where much of the Features earlier research [..] Focus on computational methods and associated software Competing methods and software are com- Features pared and relative advantages and disadvantages New cash crops with seawater irrigation. Energy pro- highlighted Helps to select the appropriate methods duction. CO2-sequestration. for a particular genetic problem

Contents Contents 1.1. Concepts for different uses of halophytes.- 1.2. Linkage analysis - qualitative traits.- Link- The water crisis – the potential of cash crop halo- age analysis - quantitative traits.- Association phytes to reduce the dilemma.- 1.3. Present efforts studies - population based.- Association studies - to develop sustainable saline production systems.- family based.- Population genetics.- Haplotype struc- 1.4. Studies on halophytes and salinity problems ture.- Haplotype association analysis.- Monte Car- in Mediterranean agriculture.- 2.1. Investigations lo analysis methods.- Multiple comparison/testing proposed in Venezuela for the development of sys- issues.- Disease risk estimation/analysis.- Other re- tems for the sustainable utilisation of halophytes.- sources. 2.2. Diagnostics about the state of mangroves in Venezuela.- 2.3. Contribution of seagrasses to the Fields of interest Venezuelan coastline vegetation.- 3.1. Comparative Human Genetics; Statistics for Life Sciences, biochemical study of the [..] Medicine, Health Sciences; Bioinformatics; Compu- tational Biology/Bioinformatics; Genetics and Popu- Fields of interest lation Dynamics; Statistical Theory and Methods Ecology; Ecosystems; Plant Ecology; Environmental Management; Climate Change Target groups professionals, researchers and advanced students Target groups working in statistical or human genetics Library item – researchers into saline ecosystems, agriculture, forestry, environmental science, land- Type of publication scape ecology around the world. Handbook

Type of publication Due April 2008 Contributed volume

2008. Approx. 550 p. Hardcover Due January 2008 149,00 € 2008. Approx. 215 p. (Tasks for Vegetation Science, Vol. 43) Hard- ISBN 978-3-540-69263-8 cover

98,00 € ISBN 978-1-4020-6719-8 springer.com/booksellers Life Science 83

B. Liu, Harvard Medical School, Boston, MA, USA (Ed.) R.A. Lockshin, St. John's University, New York, NY, USA R. Lowen, University of Antwerp, Belgium; A. Verschoren, Univer- sity of Antwerp, Belgium (Eds.) Tissue Proteomics The Joy of Science Foundations of Generic Pathways, Biomarkers, and Drug Discovery Optimization, Volume 2: This book, by a practicing and successful scientist, Applications of Fuzzy Control, explores why questions arise in science and looks at With the completion of human genome sequencing, Genetic Algorithms and Neural how questions are tackled, what constitutes a valid the field of proteomics has grown vital to biomedical answer, and why. The author does not bog down the Networks research. Among the array of protocols developed to reader in technical details or lists of facts to memo- study the human proteome, many protocols exam- rize. Instead, he places the questions in their histor- ine proteins derived specifically from cell lines, body ical and cultural context, ranging from the earliest fluids or human tissues - not necessarily compati- This is a comprehensive overview of the basics of intimations that the earth had a long history to cur- ble with the full range of protein sources common- fuzzy control, which also brings together some re- rent controversies, even describing the origins, chal- ly used in the laboratory. Tissue Proteomics consti- cent research results in soft computing, in particular lenges, and promises of modern molecular biology. tutes in one volume useful and innovative protocols fuzzy logic using genetic algorithms and neural net- Addressing issues as complex as radiocarbon dating developed specifically for the proteomic profiling of works. This book offers researchers not only a solid and how we know that DNA is a double helix, he us- human tissues. A unique resource for researchers, background but also a snapshot of the current state es examples, illustrations, and descriptions that all Tissue Proteomics provides high-throughput gel- of the art in this field. students should be able to grasp ("Were there kanga- based techniques, microarrays and a number of oth- roos in Noah’s Ark?"; "Molecular Biology Ain’t Rock- er methods used in proteomic research, a field still in Features et Science"). He gives the reader a sense of why a sci- its early stages. This important book will prove indis- Timeliness of the comprehensive overview of fuzzy entist feels always "like the child called to the stage to pensable to investigators of biomarker discovery and control Large body of authors, specialists in the field watch the magician do his trick". The author’s thesis therapeutic response profiling, as well as those forg- Articles with varied range of applications Specialist is that scientific logic is an extension of the common ing new paths in the fields of theranostics and per- up-to-date research articles + comprehensive intro- human logic [..] sonalized medicine. duction to the field in one and the same work Features Features Fields of interest Addresses the theoretical basis of science and is not Provides time tested, reproducible laboratory meth- Genetics and Population Dynamics; Mathematics of "watered-down Biology" Explains the most complex ods and protocols authored by experts in the field, Computing; Discrete Mathematics in Computer Sci- issues in a clear and non-technical manner Empha- including tips and hints Presents the most up to date ence; Combinatorics; Optimization sizes the accessibility of scientific thinking and the and useful proteomic techniques for profiling human excitement of science even to students who have tissue Provides indispensable protocols for biomark- Target groups feared or disliked what they considered to be science er discovery, therapeutic response profiling, and high Researchers and professionals in soft computing, Relates the development of scientific ideas to their throughput based techniques in particular in development of theory and applica- cultural context Emphasizes process rather than [..] tions of fuzzy logic, genetic algorithms and neural Contents networks Fields of interest Capabilities using 2-D DIGE in Proteomics Re- Biomedicine general; Evolutionary Biology; Micro- search: The New Gold Standard for Two-dimension- Type of publication bial Genetics and Genomics; Popular Science in Na- al Gel Electrophoresis.- Protein Carbohydrate Anal- Contributed volume ture and Environment ysis: Gel-based Staining, Liquid Chromatography, Mass Spectrometry and Microarray Screening.- Sur- Target groups Due October 2007 face-Enhanced Laser Desorption/Ionization Mass Undergraduates in "science for non-scientists" cours- Spectrometry (SELDI-MS) for Protein and Peptide es; beginning science students; lay public interested 2008. X, 355 p. (Mathematical Modelling: Theory and Applica- Profiling of Body Fluids.- A Novel Approach using in getting a feeling for how scientific questions are tions, Vol. 24) Hardcover MALDI-TOF/TOF Mass Spectrometry and Prestruc- raised and scientific conclusions are reached; read- tured Sample Supports (AnchorChip technology) for ers interested in the background behind the polemic 69,95 € Proteomic Profiling and Protein Identification.- Au- of evolution; members of school boards and others ISBN 978-1-4020-6667-2 tomated Laser Capture Microdissection for Tissue struggling with controversies concerning the teach- Proteomics.- [..] ing of evolution or other aspects of modern science; courses intended to interest minority students in sci- Fields of interest ence Proteomics; Animal Genetics and Genomics; Cell Bi- ology Type of publication Graduate/advanced undergraduate textbook Target groups Biomedical researchers, tissue proteomics researchers, medical practitioners Due October 2007

Type of publication 2007. Aprox. 450 p. Hardcover Contributed volume 69,95 € Due April 2008 ISBN 978-1-4020-6098-4

2007. Approx. 298 p. 31 illus. 6 in color (Methods in Molecular Biology, Vol. 441) Hardcover

79,95 € ISBN 978-1-58829-679-5 84 Life Science springer.com/booksellers

L.R. Lozny, Hunter College, New York, NY, USA (Ed.) Y. Luo, University of Oklahoma, Norman, OK, USA; B. Li, Fudan U.E. Lüttge, Technical University Darmstadt, Germany; W. University, Shanghai, China; J. Chen, University of Toledo, Tole- Beyschlag, University of Bielefeld, Germany; J. Murata (Eds.) do, OH, USA; S.-L. Yang, East China Normal University, Shanghai, Landscapes under Pressure China; J. Chen, Fudan University, Shanghai, China; C. Fang, Fudan University, Shanghai, China (Eds.) Theory and Practice of Cultural Heritage Research and Preser- vation Ecology in the Yangtze River With one volume each year, this series keeps scientists and advanced students informed of the latest de- Estuary velopments and results in all areas of the plant sci- There is a growing realization that human intent and ences. The present volume includes reviews on ge- activity are not easily separated from natural forces netics, cell biology, physiology, comparative mor- in the shaping of landscapes. The pervasive Western phology, systematics, ecology, and vegetation sci- The Yangtze River estuary is a system where geologi- dichotomy of culture and nature has proved to be a ence. cal, biological, and socioeconomic processes actively poor basis for scientific research and long-term en- interplay. The Yangtze River carries about 5 billion vironmental management. Humans have been ma- Features tons of sediment to the estuary from upstream each jor factors in environmental change for thousands of Review of the latest results in the major areas of the year, providing rich substrates for biological activi- years using fire, intensive hunting and a wide range plant sciences in the past 1-2 years ties and alluvial processes. An exotic plant species, of agricultural strategies to transform most ecosys- Spartina alterniflora was intentionally introduced tems on the earth long before the Industrial Revolu- Contents to the region in 1979, and has aggressively invaded tion. All these activites contribute to the making of From the contents Review. Ecophysiology: Migra- the Yangtze River estuary and coastal China. The bi- cultural landscapes which incorporate elements gen- tions Between Different Levels of Scaling.- Genetics. ological invasion alters plant and animal biodiversi- erally classified in two groups: tangible empirical ev- Recombination. Function of Genetic Material. Func- ty and ecosystem processes. In addition, the Yangtze idence of human behavior, and intangible, symbolic tional Markers in Resistance Breeding. Extranucle- River estuary is close to Shanghai, one of the most meanings. This book investigates the newly emerg- ar Inheritance: Plastid-nuclear Cooperation in Pho- economically active cities in China and the world. ing scope of interests and project agendas to investi- tosystem I Assembly in Photosynthetic Eukaryotes. Fast economic development and social transforma- gate and preserve cultural landscapes. It presents the Molecular cell biology: Are Reactive Oxygen Species tion exert great pressure to exploit resources in the historic, archaeological, ethnographic, and environ- Regulators of Leaf Senescence?- Physiology. Applica- estuary. In the last few decades, scientists from sev- mental traditions of cultural landscape study and the tion of Laser-assisted Microdissection for Tissue and eral leading universities in China have conducted re- attempts to reconstruct and [..] Cell-specific Analysis of RNA, Proteins, and Metabo- search on many of geological, biological, and socioe- lite. Crassulacean Acid Metabolism: a Cause or Con- Features conomic processes. An increasing number of papers sequence of Oxidative Stress in [..] An interdisciplinary approach to landscape archaeol- have been published in [..] ogy will be interest to archaeologists (especially cul- Fields of interest Features tural heritage managers), historians, ethnographers, Plant Physiology; Plant Genetics & Genomics; Plant A comprehensive synthesis of ecological research on environmentalists and ecologists Ecology the Yangtze River and Estuary system A reference for Contents the management of other major estuarine ecosystems Target groups Introduction.- Part I: Theory.- Place, Problem and Includes sections on biodiversity, ecological process- Plant scientists People: Issues in Interdisciplinary Cooperation.- es, and human impacts Type of publication Place, Historical Ecology and Cultural Landscape: Contents Reference work New Directions for Culture Resource Management.- Part I: Overview on the Yangtze River Estuary.- Abi- The Colonial Southwest: Pueblo and Spanish Shared otic Processes in the Yangtze River Estuary.- His- and Separate Landscapes.- A New Landscape for Due October 2007 torical Changes in the Yangtze River Estuary.- Part Cultural Heritage Management: Characterization as II. Biodiversity: Plant and Vegetation.- Plankton.- a Management Tool.- The Site as a Modern Local- Benthos in the Yangtze Estuary with Emphasis on 2008. Approx. 470 p. 33 illus. (Progress in Botany, Vol. 69) Hard- ity.- Part II: Methodology and Practice.- Changing cover Benthic Fauna in Salt Marshes.- Fish and Fisheries.- Places: Developing an archaeology of place at Low- Waterbirds and their Habitats in the Yangtze Riv- er Pescado Village, Zuni, New Mexico.- Envisioning 239,00 € er Estuary.- Part III. Ecological Processes: Leaf and Future Landscapes in the Environmentally Sensitive ISBN 978-3-540-72953-2 Canopy Processes of Three Dominant YRE Plant [..] Species.- Plant Productivity and Ecosystem Carbon Fields of interest Cycles in Yangtze River Estuary Wetlands.- Soil Bio- Archaeology; Landscape Ecology geochemical Processes in the Yangtze [..]

Target groups Fields of interest Archaeologists - especially cultural heritage man- Ecology; Waste Water Technology / Water Pollution agers, anthropologists, ethnographers, historians and Control / Water Management / Aquatic Pollution; environmental planners Ecosystems; Nature Conservation; Environmental Management; Biodiversity Type of publication Contributed volume Target groups Ecologists; researchers in soil science, earth system science, atmospheric science, biogeochemistry, and Due January 2008 global change biology

2008. Approx. 260 p. Softcover Type of publication Contributed volume 26,95 € ISBN 978-0-387-75720-9 Due August 2008

2008. Approx. 495 p. 40 illus. (Ecological Studies, Preliminary entry 1001) Hardcover

114,75 € ISBN 978-0-387-76769-7 springer.com/booksellers Life Science 85

U.E. Lüttge, Technische Hochschule Darmstadt, Germany F.T. Manheim, George Mason University, Fairfax, VA, USA G.A. Manley, Technische Universität München, Germany; R.R. Fay, Loyola University of Chicago, IL, USA; A.N. Popper, University of Maryland, College Park, USA (Eds.) Physiological Ecology of Tropical Fateful Collision

Plants Environmental Conflict and Political Gridlock in the US Active Processes and Otoacoustic Emissions

In spite of international agreements at the political This book traces the origin of the current conflict be- level not much has changed since the late 1980s in tween environmentalists and industry in the Unit- Sounds that are actually produced by healthy ears al- terms of reducing the speed of destruction of origi- ed States. It shows how the crisis of the San- low researchers and clinicians to study hearing and nal tropical environments. However, since the publi- ta Barbara offshore oil spill in 1969 led to the pas- cochlear function noninvasively in both animals and cation of the first edition ten years ago, internation- sage of radically new environmental laws that had humans. This book presents the first serious review al research efforts in physiological ecology of plants rapid impact on pollution, making the US an inter- of the biological basis of these otoacoustic emissions. in the tropics has increased enormously in quantity national leader in environmental protection at the Active processes, such as those in hair cells that pro- and quality. In some fields advances were more sub- time. However, the regulatory approach of duce emissions, represent a burgeoning and impor- stantial than in others. New approaches came up in the laws proved inferior to performance-based mod- tant area of sensory research. By providing a basis for remote sensing and at the other end of the scope in els as developed in other parts of the world and was understanding how and why otoacoustic emissions some areas molecular biology was particularly devel- therefore detrimental to both environmental and in- testing works through a basic understanding of gen- oped regarding ecological performance of tropical dustry performance. In addition, the rigidity eral hearing processes, this volume will also interest plants, e.g. in understanding the adaptation of resur- of the regulatory system deepened the confrontation clinicians, particularly otolaryngologists and audiol- rection plants to the extreme habitat of inselbergs. between environmental and industrial groups, caus- ogists. The wealth of new information made it necessary to ing a rift which spread to other areas of politics and break large chapters down into smaller ones. Tropi- society. The author analyses the current situ- Features cal forests which occupy about half of the entire vol- ation based on historic developments and presents Presents the first serious review of the biological ba- ume of the book were now arranged in 5 chapters a comparison with environmental developments in sis of otoacoustic emissions covering structure and function under the influence other advanced nations. of environmental cues and [..] Contents Features Otoacoustic Emissions-Origins.- Traveling Waves, Features Author presents controversial view on current envi- Second Filters and Physiological Vulnerability: A Fully revised and updated 2nd edition Covers all ma- ronmental policy situation in US, tracing back to Na- Short History of the Discovery of Active Processes jor tropical ecosystems from tropical forests to sa- tional Environmental Policy Act in 70s Presents case in Hearing.- Critical Oscillators as Active Elements vannas, salinas, inselbergs and páramos studies to compare US to European countries (Fin- in Hearing.- Active Hair-Bundle Motility of the Hair land, Sweden, Norway, Germany) more successful Contents Cells of Vestibular and Auditory Organs.- The Mor- (in his point of view) in environmental policies Envi- phological Specializations and Electromotility of Introduction. Large-Scale Sensing and Diagnosis ronmental problems and climate change are hot top- in Relation to the Tropical Environment. Tropi- the Mammalian Outer Hair Cell.- Active Processes ics, book should have audience both in US and ROW in Insect Hearing.- Otoacoustic Emissions in Am- cal Forests I: Physiognomy and Functional Struc- (mainly Europe) ture. Tropical Forests II: Ecophysiological Respons- phibians, Lepidosaurs and Archosaurs.- Otoacous- tic Emissions: Basic Studies in Mammalian Models.- es to Light. Tropical Forests III: Ecophysiological Contents Mechanisms of Mammalian Otoacoustic [..] Responses to Drought. Tropical Forests IV: Lianas, Current Conflict.- Tracing the Roots.- Looking Hemi-epiphytes, Epiphytes and Mistletoes. Tropical Back.- Results of the Environmental Regulatory Sys- Fields of interest Forests V: Mangroves. Ecosystems of Coastal Sand tem of the 1970s.- Why Does Polarization Matter?.- Neurobiology; Human Physiology; Neurosciences; Plains. Savannas I: Physiognomy, Terminology and Reform Movements and the Future.- Case Studies Neurology; Otorhinolaryngology Ecotones: Why Do Savannas Exist? Savannas II: The and Examples.- Policy Analysis and Comparisons.- Environmental Factors Water, Mineral Nutrients Notes.- References.- Index Target groups and Fire. Inselbergs. Páramos.- Researchers, graduate students Fields of interest Fields of interest Environmental Economics; Environmental Manage- Type of publication Plant Sciences; Ecology ment; Political Science Monograph Target groups Target groups Graduate students and researchers Policy makers Environmental groups Researchers in Due February 2008 environmental and political science Type of publication 2007. Approx. 425 p. 126 illus. (Springer Handbook of Auditory Graduate/advanced undergraduate textbook Type of publication Research, Vol. 30) Hardcover Monograph Due December 2007 109,95 € Due September 2008 ISBN 978-0-387-71467-7 2008. Approx. 400 p., 256 illus., 53 tabs Hardcover 2008. Approx. 250 p. Hardcover 59,95 € ISBN 978-3-540-71792-8 46,20 € ISBN 978-0-387-75876-3 springer.com/booksellers Life Science 86

R. Margesin, University of Innsbruck, Austria; F. Schinner, Univer- S. Martin, University of Nottingham, UK (Ed.) B. Martinac, University of Queensland, Australia (Ed.) sity of Innsbruck, Austria; J.-C. Marx, University of Liege, Belgium; C. Gerday, University of Liege, Belgium (Eds.) Angiogenesis Protocols Sensing with Ion Channels Psychrophiles: from Biodiversity to Biotechnolgy All living cells are able to detect and translate envi- Fields of interest ronmental stimuli into biologically meaningful sig- Cell Biology nals. Sensations of touch, hearing, sight, taste, smell The majority of the Earth’s biosphere is cold and ex- or pain are essential to the survival of all living or- Type of publication posed to temperatures below 5°C throughout the ganisms. The importance of sensory input for the ex- Contributed volume year. Having evolved special mechanisms to over- istence of life thus justifies the effort made to under- come the life-endangering influence of low temper- stand its molecular origins. Sensing with Ion Chan- atures, psychrophiles, i.e. cold-adapted microor- Due January 2009 nels focuses on ion channels as key molecules en- ganisms, have successfully colonized these environ- abling biological systems to sense and process the ments. Cold adaptation includes a complex range of 2008. Approx. 300 p. (Methods in Molecular Medicine, Prelimi- physical and chemical stimuli that act upon cells in structural and functional adaptations at the level of nary entry 2002) Hardcover their living environment. Its aim is to serve as a ref- all cellular constituents, and these adaptations ren- erence to ion channel specialists and as a source of der cold-adapted organisms particularly useful for 74,95 € new information to non specialists who want to learn biotechnological applications. This book presents the ISBN 978-1-58829-907-9 about the structural and functional diversity of ion most recent knowledge of (i) boundary conditions channels and their role in sensory physiology. for microbial life in the cold, (ii) microbial diversity in various cold ecosystems, (iii) molecular cold adap- Features tation mechanisms and (iv) the resulting biotechno- First book which is not exclusively focused on ion logical perspectives. channels functioning in sensory mechanisms that are characteristic of animals and humans, but also Features describes the role of ion channels in signal transduc- All chapters are written by leading scientists in their tion mechanisms found in microbial cells and plants respective fields Includes basic research results and Summarizes comprehensively the progress that has applied biotechnological aspects been made in studies of ion channels and their role in sensory physiology Addressing a great variety of Fields of interest [..] Microbial Genetics and Genomics; Microbial Ecol- ogy; Biotechnology; Biochemistry, general; Applied Fields of interest Microbiology; Astrophysics Biophysics; Biochemistry, general; Cell Biology; Bioorganic Chemistry Target groups Researchers in microbiology, microbial ecology, bio- Target groups chemistry, and biotechnology Institutes, libraries, scientists

Type of publication Type of publication Contributed volume Contributed volume

Due November 2007 Due November 2007

2008. Approx. 460 p. Hardcover 2007. XXIII . 304 p. 46 illus, 6 in color. (Springer Series in Bio- physics, Vol. 11) Hardcover 199,95 € ISBN 978-3-540-74334-7 139,95 € ISBN 978-3-540-72683-8 springer.com/booksellers Life Science 87

M.L. Martínez, Institute of Ecology, Xalapa, Mexico; N.P. Psuty, A. Marx, Konstanz University, Konstanz, Germany; O. Seitz, Hum- J. Marzluff, University of Washington, Seattle, WA, USA (Ed.) Rutgers University, New Brunswick, NJ, USA (Eds.) boldt University Berlin, Berlin, Germany (Eds.) Urban Ecology Coastal Dunes Molecular Beacons An International Perspective on the Interaction Between Hu- Ecology and Conservation Signalling Nucleic Acid Probes, Methods, and Protocols mans and Nature

Coastal dunes occur in almost every latitude - from Significant DNA sequence data has been made avail- Nearly thirty years after creation of the most ad- tropical to polar - and have been substantially altered abe by several important genome projects. We clear- vanced and expensive hazardous waste cleanup in- by human activities. Many are already severely and ly live in an exciting era, in which the allocation of frastructure in the world, Reclaiming the Land pro- irreversibly degraded. Although these ecosystems functions to a mere string of the four letters in the vides a much-needed lens through which the Super- have been studied for a long time (as early as 1835), code of life plays a major if not the predominant role fund program should be assessed and reshaped. Fo- there has been a strong emphasis on the mid-lati- of ongoing and future research. In functional ge- cusing on the lessons of adaptive management, it ex- tude dune systems and a lack of attention given to nomics techniques are required that allow to exam- plores new concepts and tools for the cleanup and the tropics where, unfortunately, much of the mod- ine the occurrence of gene products (be it RNA or reuse of contaminated sites, and for dealing with the ern exploitation and coastal development for tourism protein material) and their interplay with other gene uncertainty inherent in long-term site stewardship. is occurring. This book brings together coastal dune products, if possible, in real time. Again, once an im- Its contributors include scholars and practitioners specialists from tropical and temperate latitudes, portant function has been identified there will be de- representing many decades of experience with the which together cover a wide set of topics, including: mands to trace or screen that function in in vitro and Superfund program as well as a variety of disciplines. geomorphology, community dynamics, ecophysiolo- in vivo systems. For example, it may be necessary to "This excellent collection provides a range of per- gy, biotic interactions and environmental problems detect dissimilarities in RNA expression between in- spectives on making the Superfund program work and conservation. A major product of this book is a dividuals or it may be required to detect pathogenes even better for the American people. The unifying set of recommendations for future research, identify- as rapid as possible. Progress in functional genomics concept of adaptive management offers broad, gen- ing relevant topics where detailed knowledge is still as well as molecular diagnostics requires the avail- erally applicable ways of improving cleanup and lacking. It also identifies management tools that will ablity of methods that allow quantitative measure- reuse of many types of contaminated sites." Carol M. promote and maintain the rich diversity of the dune ments in almost any environment, if desired even Browner, Principal, The Albright Group and Former environments in the context [..] within living cells, with [..] Administrator, United States Environmental Protec- tion [..] Features Features Leads to a better understanding of dune ecosystems Shows a diverse set of instructive examples from Features and to the generation of improved conservation and probe design to applications in clinical settings guid- Presents a comprehensive view of the urban ecosys- management strategies ed by experts in the field who provide easy to follow tem by introducing drivers, patterns, processes and experiments The book commences with an intro- effects of human settlements and the relationships Contents duction to the basic principles of fluorescence Ex- between humans and other animals, plants, ecosys- From the contents: What Are Sand Dunes?- The Flo- tends the potential of realtime PCR Contributions tem processes, and abiotic conditions ra and Fauna of Sanddunes.- Living in a Stressful advocate simplifications of the probe technologies Environment.- Biotic Interactions.- Environmen- Presents a new simplified molecular beacon design Contents tal Problems and Conservation.- The Coastal Dune EasyBeacons [..] Introduction.- Section I Urbanization and Human Paradox: Conservation vs. Exploitation? The com- Domination of Earth.- Section II Conceptual Foun- plete table of contents can be found on the internet: Contents dations of Urban Ecology.- Section III The Atmo- springeronline.com Basic Principles of Fluorescence and Energy Trans- sphere, Hydrosphere, and Pedosphere.- Section IV fer.- Multiplex Detection of Mutations.- Detection The Biosphere.- Section V The Anthroposhere: Hu- Fields of interest of Salmonella species in foodstuffs.- Identification of man Dimensions.- Section VI The Anthroposphere: Ecology; Nature Conservation; Plant Sciences; Zool- homozygous transgenic mice by genomic real time Planning and Policy. ogy; Environmental Management; Biodiversity PCR.- Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the Fields of interest Target groups LightCyclerÒ instrument and a SYBR GreenI based Landscape/Regional and Municipal Planning; Ecolo- Researchers, environmental managers, conservation- assay: determining FAT10 mRNA levels in hepato- gy; Biodiversity; Landscape Ecology; Nature Conser- ists, and advanced students cellular carcinoma.- Absolute quantitation of Feline vation Leukemia Virus (FeLV) proviral DNA and viral RNA Type of publication loads by TaqMan® Real-time PCR and RT-PCR.- Target groups Reference work High throughput real-time PCR.- Design and Use of Researchers, students, and practitioners in the fields [..] of urban ecology, landscape architecture, urban de- Due October 2007 sign and planning, conservation biology, geography, Fields of interest wildlife science, and sustainable development Human Genetics; Biotechnology; Animal Genetics 2008. XXIV, 388 p. 108 illus., 3 in color. With series ad on (virtual) Type of publication p. 387, 388. (Ecological Studies, Vol. 171) Softcover and Genomics Contributed volume 54,95 € Target groups ISBN 978-3-540-74001-8 Geneticist, biotechnologists, molecular and cellular Due January 2008 biologists, drug researchers and developers

Type of publication 2008. Approx. 650 p. Hardcover Contributed volume 54,95 € ISBN 978-0-387-73411-8 Due January 2008

2008. Approx. 274 p. 60 illus. 17 in color (Methods in Molecular Biology, Vol. 429) Hardcover

79,95 € ISBN 978-1-58829-700-6 88 Life Science springer.com/booksellers

R. Matthiesen, CIC bioGUNE, Derio, Spain (Ed.) R.J. McMahon, Mead Johnson Nutritionals, Evansville, IN, USA S.E. McNeil, Nanotechnology Characterization Lab, Frederick, MD, (Ed.) USA (Ed.) Clinical Proteomics Avidin-Biotin Interactions Characterization of Nanoparticles Methods, Applications, and Tools Methods and Applications Intended for Drug Delivery

Fields of interest This book is specifically about the application of the Proteomics; Bioinformatics; Cell Biology extremely powerful interaction between the protein Fields of interest avidin or its homologues and the vitamin biotin and Cell Biology Type of publication some of its homologues. With excellent descriptions Type of publication Contributed volume of laboratory protocols written by expert researchers, Contributed volume this volume is equally perfect for the student or the Due April 2009 professional laboratory scientist. Due June 2009 Contents 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Preparation of avidin conjugates.- Coupling of anti- entry 2205) Hardcover 2009. (Methods in Molecular Biology, Preliminary entry 2232) bodies with biotin.- Optimization of detection and Hardcover 76,65 € quantification of proteins on membranes in very ISBN 978-1-60327-193-6 high and very low abundance using avidin and strep- 76,65 € tavidin.- Use of the Avidin (Imino)biotin System as ISBN 978-1-60327-197-4 a general approach to affinity precipitation.- Cap- turing biotinylated proteins and peptides by avidin functional affinity electrophoresis.- Functionality Screening of Streptavidin Mutants by Non-Denatur- ing SDS-PAGE Using Biotin-4-Fluorescein.- Appli- cation of biotin-4-fluorescein in homogeneous fluorescence assays for avidin, streptavidin, [..]

Fields of interest Cell Biology; Biochemistry, general; Biotechnology; Immunology

Target groups Biochemists, protein scientists, biotechnologists, immunologists, molecular biologists

Type of publication Contributed volume

Due November 2007

2008. Approx. 240 p. 38 illus. (Methods in Molecular Biology, Vol. 418) Hardcover

76,65 € ISBN 978-1-58829-583-5 springer.com/booksellers Life Science 89

P. Meire, University of Antwerp, Belgium; M. Coenen, University P. Meire, University of Antwerp, Belgium; M. Coenen, University B.C. Meyers, University of Delaware, Newark, DE, USA; P.J. Green, of Antwerp, Belgium; C. Lombardo, Italian Embassy in Belgium of Antwerp, Belgium; C. Lombardo, Italian Embassy in Belgium University of Delaware, Newark, DE, USA (Eds.) Italian Permanent Representative to NATO, Belgium; M. Robba, Italian Permanent Representative to NATO, Belgium; M. Robba, University of Genova, Italy; R. Sacile, University of Genova, Italy University of Genova, Italy; R. Sacile, University of Genova, Italy (Eds.) (Eds.) Plant MicroRNAs

Integrated Water Management Integrated Water Management

Practical Experiences and Case Studies Practical Experiences and Case Studies Contents Overview of plant miRNAs (biogenesis).- miRNA discovery (prediction).- miRNA discovery (sequenc- Water is essential for a wide range of human activi- Water is essential for a wide range of human activi- ing).- Purification of ago-associated miRNAs.- miR- ties and it exists in relatively finite amounts. When ties and it exists in relatively finite amounts. When NA target prediction.- miRNA target validation.- dealing with water management, different issues dealing with water management, different issues Artificial microRNAs.- Small RNA bioinformat- should be combined: water demand, water quality, should be combined: water demand, water quality, ics analyses.- miRNA microarrays.- miRNA in situ irrigation and food production, ecosystem preserva- irrigation and food production, ecosystem preserva- hybridizations.- miRNA sensors/reporters.- tion, cost minimization, technological options, leg- tion, cost minimization, technological options, leg- miRNA quantification (RT-PCR kits).- miRNA islative frameworks, social impact. The main goal of islative frameworks, social impact. The main goal of turnover and modifications.- miRNA promoter anal- the book is to give a general framework about Inte- the book is to give a general framework about Inte- ysis.- miRNA comparative analyses.- Stress- grated Water Management (IWM), that is the plan- grated Water Management (IWM), that is the plan- induced miRNAs.- Viral suppressors for miRNA ning and management of water resources integrat- ning and management of water resources integrat- analysis.- Purification of small RNA binding pro- ing the different issues involved (ecological, econom- ing the different issues involved (ecological, econom- teins.- Transient [..] ic, technical legislative, transboundary, etc.). The ic, technical legislative, transboundary, etc.). The Fields of interest manuscript is the result of the research activity and manuscript is the result of the research activity and Cell Biology; Plant Sciences the exchange of knowledge among a team of experts the exchange of knowledge among a team of experts in different disciplines and institutions related to in different disciplines and institutions related to Type of publication water resources, and includes both the different en- water resources, and includes both the different en- Contributed volume vironmental problems that affect the very different vironmental problems that affect the very different ecosystems, and the main methodologies able to face ecosystems, and the main methodologies able to face the problem of IWM. The book is divided in three the problem of IWM. The book is divided in three Due February 2009 parts: Concepts and approaches of IWM (Part [..] parts: Concepts and approaches of IWM (Part [..] 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Features Features entry 2214) Hardcover Result of the work of international experts in differ- Result of the work of international experts in different disciplines related to IWM Current methodolog- ent disciplines related to IWM Current methodolog- 76,65 € ical approaches are presented Case studies from all ical approaches are presented Case studies from all ISBN 978-1-60327-004-5 over the world are described Main problems and fu- over the world are described Main problems and future directions for IWM are discussed ture directions for IWM are discussed

Fields of interest Fields of interest Environmental Management; Waste Water Tech- Environmental Management; Waste Water Tech- nology / Water Pollution Control / Water Manage- nology / Water Pollution Control / Water Manage- ment / Aquatic Pollution; Ecosystems; Environmen- ment / Aquatic Pollution; Ecosystems; Environmen- tal Computing/Environmental Modelling tal Computing/Environmental Modelling

Target groups Target groups Scientists and water managers who have to deal with Scientists and water managers who have to deal with the planning and management of water resources the planning and management of water resources use, taking into account the different issues (eco- use, taking into account the different issues (economic, environmental, political, social, ecological) nomic, environmental, political, social, ecological)

Type of publication Type of publication Proceedings Proceedings

Due October 2007 Due October 2007

2007. X, 380 p. (Nato Science Series: IV: Earth and Environmental 2007. X, 380 p. (Nato Science Series: IV: Earth and Environmental Sciences, Vol. 80) Softcover Sciences, Vol. 80) Hardcover

69,95 € 159,95 € ISBN 978-1-4020-6551-4 ISBN 978-1-4020-6550-7 90 Life Science springer.com/booksellers

A. Mikhailov, Wadsworth Center, Albany, NY, USA (Ed.) N. Mimura, Ibaraki University, Hitachi, Japan (Ed.) E.A. Miska, University of Cambridge, UK (Ed.)

Practical Fluorescence Microscopy Asian-Pacific Coasts and Their MicroRNAs in Development in Mammalian Cells Management

Protein Localization and Function States of Environment Fields of interest Developmental Biology This volume presents a multidisciplinary approach The Asia-Pacific region is home to the world’s largest to microscopy emphasizing a thorough and integra- region of coral reefs and mangroves. It accommo- Target groups tive approach to imaging experiments starting with dates two-thirds of the world’s human population Advanced undergraduates, graduate students, post- a testable hypothesis (question), proceeding through and its economic activities have the highest growth docs the test-tube stage of making the reagents to the mi- rate in the world. Ongoing degradation of the envi- Type of publication croscopy stage of introducing the reagents into the ronment, resulting from coastal development, de- Contributed volume cells and their eventual imaging. Each chapter cul- forestation, desertification and over-harvesting, are minates with the advice on the interpretation and becoming a matter of great concern, as floods and analysis of images to determine your experimental droughts occur as a result of this degradation. The Due April 2009 results. This book addresses the practical questions Asia-Pacific region also includes part of the ‘Pacif- regarding benefits and pitfalls of various techniques ic Rim of Fire’ and is, therefore, vulnerable to earth- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary and the interpretation of results. Each technique is il- quakes and tsunamis, as the world became aware fol- entry 2202) Hardcover lustrated by photomicrographs showing the "normal" lowing the Sumatra earthquake and tsunami on 26 appearance of the structure or phenomenon studied December 2004. Threats of global environmental 76,65 € as well as methodology- related artifacts. change, such as climate change and sea-level rise, will ISBN 978-1-60327-187-5 exacerbate such problems. Therefore, appropriate Fields of interest policies and measures are needed for coastal man- Cell Biology; Animal Genetics and Genomics; Ani- agement, to address both the local and global trends. mal Biochemistry This book gives an overview of the state-of-the-art understanding on the drivers, state, and [..] Target groups Molecular and cellular biologists, geneticists, bio- Features chemists Provides state-of-the-art understanding of the state of the environment Structural approach consisting Type of publication of drivers, state, and responses to the coastal envi- Contributed volume ronmental changes Describes both local and global trends including climate change and sea-level rise Due November 2008 Provides an objective basis of the perspective using the latest data Gives good practices to indicate desir- 2009. Approx. 300 p. Hardcover able future direction of coastal management for [..]

74,95 € Contents ISBN 978-1-58829-061-8 From the contents 1. Introduction (Mimura and Ya- mamura).- 2. Drivers for changes of coastal zone (Yanagi and Cho).- 3. Environment problems in the coastal zone (Sekiguchi and Sanit).- 4. Policy for the conservation and sustainable development of coastal zone (Hirai, Yamao and Shikida).- 5. Regional conditions (Saito and Alino).- 6. Conclusion (Mimura).

Fields of interest Oceanography; Environmental Management; Re- gional Science; Climate Change; Geoecology/Natural Processes

Target groups This book will be of interest to researchers of coastal science, undergraduate and graduate students of coastal science, engineering and management, to policy makers, coastal managers and coastal developers, and to the fishing industry.

Type of publication Monograph

Due January 2008

2008. Approx. 350 p. (Coastal Systems and Continental Margins, Vol. 11) Hardcover

129,95 € ISBN 978-1-4020-3626-2 springer.com/booksellers Life Science 91

G. Mor, Yale University School of Medicine, New Haven, CT, USA; D.J. Morré, Purdue University, West Lafayette, IN, USA; H.H. Mol- M.R. Mozafari, Monash University, Victoria, Australia (Ed.) A. Alvero, Yale University School of Medicine, New Haven, CT, lenhauer, College Station, TX, USA USA (Eds.) Nanomaterials and Nanosystems The Golgi Apparatus Apoptosis and Cancer for Biomedical Applications The First 100 Years Methods and Protocols "Nanomaterials and Nanosystems for Biomedical The Golgi Apparatus: The First 100 Years traces the Applications" brings together under a single cover The aim of Apoptosis and Cancer is to describe the first century of GA discovery from the first published various aspects of functional bioengineered materi- performance of contemporary techniques for study- accounts in 1898, to the Centenary Celebration in als and nanostructured biomaterials including coming the biology of apoptosis and its role in cancer. 1998, to our most recent discoveries. It summarizes monly used implants and sustained release nanode- The protocols described will aid both the academic the past 50 years beginning with the modern era of vices. The book includes expert reviews on the ad- laboratory interested in further characterizing the GA discovery in 1954, leading up to the present era vances and current problems associated with the mechanisms of apoptosis, as well as the industry lab- with almost exclusive focus on molecular biology. implants and nanodevices along with their appli- oratory, aimed at identifying new target molecules or Emphasized are organization and function (especial- cations in medicine, pharmaceutics, cancer thera- screening for new compounds with potential clinical ly in plants), the existence and importance of cister- py, gene transfer and drug delivery. The editor, M. use. nal tubules, development of methods of plant and R. Mozafari (PhD), has been working in the field animal GA isolation and subfractionation, the con- of nanobiotechnology for the past 14 years and has Features cept of GA function as part of an integrated system produced more than 60 publications. The book al- Readily reproducible, cutting-edge techniques for of internal endomembranes, evidence for differentia- so describes the key research parameters pertaining studying the biology of apoptosis Step-by-step in- tion of membranes across the stacks of GA cisternae, to major technologies employed in the field. To put structions that ensure successful results Tricks of the and flux of membrane constituents along the polarity it in perspective, all important aspects dealing with trade and notes on troubleshooting and avoiding gradient defined by membrane differentiation all cul- the chemistry, physics, biology and engineering of known pitfalls minating in the membrane maturation or flow dif- nanostructured biomaterials and their applications ferentiation model of GA function. More recent con- in nanobiotechnology are covered. Contents tributions to GA in cell growth (enlargement) and to Modulation of Apoptosis to Reverse Chemoresis- cancer are summarized in the final chapters. Features tance.- Caspase-3 Activation is a Critical Determi- New scientific area (nanobiotechnology) with in- nant of Genotoxic Stress-Induced Apoptosis.- Flow Features creasing interest Designed as a useful resource for cytometry enumeration of apoptotic cancer cells by Presents a historical review of Golgi Apparatus re- everyone interested in areas including biomaterials apoptotic rate.- Detection of cancer-related proteins search Offers a summarization of the the modern era science, biotechnology, drug delivery, gene therapy in fresh-frozen ovarian cancer samples using Laser of Golgi Apparatus discovery including cell fraction- and food technology A collection of scientific articles capture microdissection.- Flow cytometric detection ation and biochemical analysis Focuses on molecular from top research scientists in the field An up to date of activated caspase-3.- The ChemoFx® Assay: An biology and discusses cell growth contributions source containing recent citations and bibliographies Ex Vivo Chemo-Sensitivity and Resistance Assay for Indispensable source of information for new [..] Predicting Patient Response to Cancer Chemother- Contents apy.- Correlation of caspase activity and in vitro History of the Golgi Apparatus.- Morphology of the Fields of interest chemo-response in epithelial ovarian cancer [..] Golgi Apparatus (Architecture/Structure).- Isolation Biomedicine general; Biotechnology; Biomaterials; and Subfractionation.- Golgi Apparatus Tubules.- Nanotechnology Fields of interest Golgi Apparatus and Membrane Biogenesis.- Golgi Cancer Research; Cell Biology; Molecular Medicine; Apparatus Function in the Flow-Differentiation of Target groups Biochemistry, general Membranes.- Biochemistry of the Golgi Apparatus.- Post-graduate students, researchers, lecturers and Golgi Apparatus Function in Secretion.- Golgi Ap- technicians in the fields of biomaterials, biomedicine, Target groups paratus Replication.- Cell Free Systems for Study of biotechnology, biochemistry, medicine, pharmacy, Cancer researchers, molecular and cellular biologists, Golgi Apparatus Function.- Golgi Apparatus Func- pharmaceutics, chemical engineering and food tech- biochemists tion in Growth and Cell Enlargement.- The Gol- nology Type of publication gi Apparatus and Cancer.- The Golgi Apparatus: A Look Ahead. Type of publication Contributed volume Contributed volume Fields of interest Due November 2007 Cell Biology; Biochemistry, general; Biological Mi- Due October 2007 croscopy; Plant Biochemistry; Neurosciences; Cancer Research 2008. Approx. 270 p. 69 illus. (Methods in Molecular Biology, Vol. 2007. XVIII, 166 p. Hardcover 414) Hardcover Target groups 109,95 € 79,95 € Researchers in: Cell Biology, Biochemistry, Biological ISBN 978-1-4020-6288-9 ISBN 978-1-58829-457-9 Microscopy, Plant Biochemistry, Neuroscience, Can- cer Research, Pharmacology/Toxicology

Type of publication Monograph

Due January 2008

2008. Approx. 570 p. Hardcover

122,45 € ISBN 978-0-387-74346-2 92 Life Science springer.com/booksellers

P. Mullany, UCL Eastman Dental Institute, London, UK; A.P. W.J. Murphy, Texas A&M University, College Station, TX, USA (Ed.) K.D. Murrell, Foodborne Parasitic Zoonoses Campaign, Rockville, Roberts, UCL Eastman Dental Institute, London, UK (Eds.) MD, USA; B. Fried, Lafayette College, Easton, PA, USA (Eds.) Phylogenomics Clostridium difficile Food-Borne Parasitic Zoonoses

Fish and Plant-Borne Parasites The past decade has seen the emergence of a new This book reviews the state of the art of methods field of scientific inquiry at the intersection of phy- available for the molecular analysis and investiga- logenetics and genomics: phylogenomics. This vol- Humans suffer from numerous parasitic foodborne tion of virulence of the important human pathogen ume is a collection of protocols and resources com- zoonoses, many of which are caused by helminths. Clostridium difficile. piled by leading researchers in the field and describes The helminth zoonoses of concern in this book are many of the molecular methods and bioinformatics normally limited to diseases of animals which have Fields of interest tools that have brought this field to fruition in recent now become transmissible to humans. In the past Microbiology; Immunology; Infectious Diseases years. these diseases were limited to populations living Target groups Features in low- and middle-income countries, but the geo- Molecular biologists, microbiologists, and clinicians Contains step-by-step instructions that ensure suc- graphical limits and populations at risk are expand- cessful results Provides tricks of the trade and notes ing and changing because of growing internation- Type of publication on troubleshooting and avoiding known pitfalls al markets , improved transportation systems, and Contributed volume demographic changes (such as population move- Contents ments). The World Health Organization (WHO) has Due September 2009 From gene-scale to genome-scale phylogenetics; the estimated that the number of people currently infect- data flood in but the challenges remain.- Phyloge- ed with food borne trematodes alone exceeds 41 million, but worldwide the number of people at risk, in- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary nomic analysis by chromosome sorting and paint- cluding those in developed countries, is 750 million. entry 2247) Hardcover ing.- FISH for mapping single copy genes.- Con- struction of radiation hybrid panels.- Survey se- The increasing recognition of the public health sig- 76,65 € quencing and radiation hybrid mapping to construct nificance of these zoonoses, especially their compli- ISBN 978-1-60327-364-0 comparative maps.- Construction of high-resolution cated epidemiologies, and their links to poverty, in- comparative maps in mammals using BAC-end se- tensification of agriculture, environmental degrada- quences.- Amniote phylogenomics: testing evolution, and lack [..] tionary hypotheses with BAC library scanning and targeted clone analysis of large scale sequences from Features reptiles.- Comparative physical mapping: universal Highlights new scientific knowledge in order to overgo [..] properly assess the overall importance of a zoonosis compared to other pressing public health and devel- Fields of interest opment needs Discussions on zoonosis epidemiolo- Cell Biology; Animal Genetics and Genomics; Bioin- gy, diagnosis, basic research and clinical aspects em- formatics phasize the issues and obstacles in the way of a full understanding of the zoonosis, particularly informa- Target groups tion needed for treatment and effective prevention Geneticists, bioinformaticians, molecular biologists, and control biotechnologists Contents Type of publication The Liver Flukes.- Intestinal Flukes.- The Lung Contributed volume Flukes: Paragonimaisis.- Diphyllobothriasis: The Diphyllobothrium latum Human Infection Conun- Due November 2007 drum.- Anisakiasis.- Capillariasis.- Gnathostomia- sis.- Angiostrongyliasis.- Fascioliasis and Fasciolopsi- asis.- Immunology of The Infection.- Molecular Epi- 2008. Approx. 365 p. 52 illus. (Methods in Molecular Biology, Vol. demiology. 422) Hardcover Fields of interest 79,95 € Parasitology; Microbiology; Health Care Administra- ISBN 978-1-58829-764-8 tion; Infectious Diseases; Virology; Food Science

Target groups Parasitologists, Microbiologists, Immunologists, Vi- rologists, and graduate students and professionals in the fields of Public Health, Infectious Disease, and Food Safety/Food Science

Type of publication Contributed volume

Due November 2007

2008. XII, 436 p. 102 illus., 8 in color. (World Class Parasites, Vol. 11) Hardcover

134,95 € ISBN 978-0-387-71357-1 springer.com/booksellers Life Science 93

R.W. Myster, University of Central Oklahoma, Edmond, OK, USA W. Nellen, University of Kassel, Germany; C. Hammann, Universi- D.V. Nicolau (Ed.) ty of Kassel, Germany (Eds.) Nanodevices Based on Protein Post-Agricultural Succession in the Small RNAs: Molecular Motors Neotropics Analysis and Regulatory Functions An Engineering Approach

Post-agricultural studies have been central to the de- In recent years Molecular Biology has experienced an This book reviews the state of the art in the velopment of both the science of plant ecology and unprecedented revolution by the discovery of func- design, fabrication and operation of bio-nano-de- ecology in general. The study of old field succession tional small RNAs. The number of cellular processes vices based on protein molecular motors, as well as allows us to observe the development of the structure in which non-coding RNAs are involved is growing the challenges and the opportunities offered by al- and function of communities, as well as understand rapidly and include gene regulation on the transcrip- ternative architectures and possible applications. the role of history and initial conditions in that pro- tional, post-transcriptional and translational level. The focus of the review will be on self-propelled ma- cess. Understanding old field succession can help the To complicate matters, these processes seem to be chines, which have the highest chances to develop in public address important scientific and social issues, strongly interconnected on the one hand, and diverse autonomous dynamic nanodevices and systems of such as deforestation and forest regeneration, for- among different organisms on the other. This vol- devices based on protein molecular motors. est restoration, sustainability of agriculture, mainte- ume describes strategies for the discovery and valida- nance of biodiversity, and impacts of global climate tion of small RNAs and provides a snapshot of our Contents change on forest dynamics. Post-Agricultural Suc- current understanding of the different mechanisms Introduction * Molecular biology of protein molecu- cession in the Neotropics draws implications from triggered by small RNAs. lar motors * Biophysics of molecular motors * Motil- scientific studies for the wise management of old ity of microorganisms and cells * Experi- field ecosystems in the neotropics, where conversion Features mental aspects * Probing the functioning of protein of land to cropping systems is the most common Gives a current snapshot of a rapidly advancing field molecular motors * Modelling molecular motors * kind of disturbance and many landscapes are defined Emphasis is placed on mechanismic aspects and on Engineering aspects of devices based on molecular by areas recovering from agriculture. Written for re- variations in different organisms motors * Devices based on protein molecular motors searchers, professionals, and students of ecology, the * Perspectives book provides a [..] Contents Small Regulatory RNAs in Bacteria. Small Nucleo- Fields of interest Features lar RNAs: Identification, Structure, and Function. A Biochemistry, general; Nanotechnology; Biomedical Presents a thorough discussion of old field succes- Computational Approach to Search For Non-coding Engineering; Biophysics; Biotechnology sion studies in the neotropics Provides restoration RNAs in Large Genomic Data. Experimental Strate- and management strategies, as well as new farming gies for the Identification and Validation of Target Target groups methodologies for practical application Methods RNAs That Are Regulated by miRNAs. Protein In- This volume will be of particular interest to bioengi- described will be applicable to areas outside of the teractions with Double Stranded RNA in Eukaryotic neers, molecular biologists and biophysicists, as well neotropics as well Cells. Transitive and Systemic RNA Silencing: Both as nanoscientists working in biology, medicine, engi- Involving an RNA Amplification Mechanism? RNA neering, chemistry and physics. Contents Interference and Antisense Mediated Gene Silencing. Patterns of Living and Non-Living Components Epigenetic Silencing of Transposons in the Green Type of publication of Old Fields after Abandonment.- Introduction.- Alga Chlamydomonas reinhardtii. RNA Dependent Contributed volume Trends in Above and Belowground Carbon with Gene [..] Forest Regrowth after Agricultural Abandonment in the Neotropics.- Post Sugar Cane Succession in Fields of interest Due January 2008 Moist Alluvial Sites in Puerto Rico.- Soil Fungi and Biochemistry, general; Cell Biology; Developmental Macrofauna in the Neotropics.- Earthworms and Biology 2008. Approx. 250 p. (Fundamental Biomedical Technologies, Post-Agricultural Succession.- Mechanisms and Tol- Preliminary entry 105) Hardcover erances that Cause Plant-Plant Replacements, Pro- Target groups ducing Old Field Vegetation Patterns.- Factors Af- Scientists and researchers in biochemistry and 104,95 € fecting The Species Richness and Composition of molecular biology, advanced students ISBN 978-0-387-30755-8 Neotropical Secondary Succession: A Case Study of Abandoned [..] Type of publication Monograph Fields of interest Environmental Management; Plant Ecology; Land- Due October 2007 scape Ecology; Applied Ecology; Nature Conserva- tion 2008. XII, 219 p. 32 illus. (Nucleic Acids and Molecular Biology, Vol. 17) Softcover Target groups Students, researchers, managers, policy-makers 44,95 € ISBN 978-3-540-74270-8 Type of publication Professional book

Due October 2007

2008. XIV, 308 p. 50 illus. Hardcover

119,95 € ISBN 978-0-387-33641-1 94 Life Science springer.com/booksellers

J. Nielsen, Center for Microbial Biotechnology, Kgs. Lyngby, Den- K.L. Nielsen, Aalborg University, Aalborg, Denmark (Ed.) J.E. Norris, Halcrow Group Ltd., Peterborough, U.K.; A. Stokes, IN- mark; M. Jewett, Center for Microbial Biotechnology, Kgs. Lyng- RA, Montpellier, France; S.B. Mickovski, Jacobs UK Ltd., Glasgow, by, Denmark (Eds.) U.K.; E. Cammeraat, IBED, University of Amsterdam, The Nether- Serial Analysis of Gene Expression lands; R. van Beek, Utrecht Centre of Geosciences, Utrecht Uni- versity, The Netherlands; B.C. Nicoll, The Forestry Commission, Metabolomics (SAGE) Midlothian. IL; A. Achim, Faculté de Foresterie et de Géomatique, Université Laval, Québec, Canada (Eds.) A Powerful Tool in Systems Biology Methods and Protocols Slope stability and erosion control:

The metabolome comprises the complete set of Serial Analysis of Gene Expression: Methods and Ecotechnological solutions metabolites, the non-genetically encoded substrates, Protocols facilitates the introduction of SAGE into intermediates, and products of metabolic pathways, the laboratory, and provides a framework for interpreting and comparing data derived from SAGE ex- associated to a cell. Given the increasing demand This book is designed to assist the civil and geotech- periments. Of the several methods of genetic profil- to quantitatively identify the metabolome and un- nical engineer, geomorphologist, forester, landscape ing available, only SAGE measures the expression of derstand how trafficking of metabolites through architect or ecologist in choosing ecotechnologi- both known and unknown genes. SAGE studies en- the metabolic network impact cellular behavior, cal solutions for slopes that are prone to a variety compass 50,000 tags and can provide detailed knowl- metabolomics has emerged as an important comple- of mass movements e.g. shallow failure or erosion. edge of the 2000 most highly expressed genes in the mentary technology to the cell-wide measurements Within this book, the ‘engineer’ is used in the global tissue sample. The SAGE protocols presented are de- of mRNA, proteins, fluxes, and interactions (e.g. pro- sense to encompass all planners, designers, etc who tailed, fully annotated, and tested, and are all writ- tein-DNA). Metabolomics is already a powerful tool are involved in the stabilisation of slopes. We review ten by experienced SAGE researchers from around in drug discovery and development and in metabol- the types of problematic slopes that may occur and the world. Part 1 is dedicated to experimental proce- ic engineering. While maintaining these strengths, describe briefly the nature of mass movements and dures of SAGE and related methods including aRNA the field promises to play a heightened role in sys- the causes of these movements. In this book, we fo- LongSAGE, SuperSAGE, DeepSAGE, and GMAT. tems biology research, which is transforming the cus on the use of vegetation to stabilize soil on slopes Part 2 provides methods for extraction and filtration practice of medicine and our ability to engineer liv- prone to mass movements. Before a plant can be of tags, analysis of ditag populations, and completing ing organisms. This book brings together the latest chosen for a particular function, its physical and hy- statistically correct comparisons of gene expression results in the field of metabolomics. It comprehen- drological properties must be determined, thus the profiles. sively presents the current state of the metabolomics root architecture of grasses, shrubs and trees are de- field by underscoring experimental methods, analysis Features scribed and the soil hydrological and mechanical fac- [..] SAGE, LongSAGE, SuperSAGE, DeepSAGE, and tors which influence vegetation are discussed. De- pending on the use of the slope, the engineer may Features GMAT protocols Correction of technology-relat- wish to ascertain either the [..] Gives a fresh substantial and in-depth overview on ed artifacts in SAGE Duplicate ditag analysis in LongSAGE Statistical comparison of two or more metabolomics Addresses all major challenges of the Features SAGE libraries Identifying non-specific SAGE tags field Offers real strategies for understanding cellular New scientific research and practical advice in the by context of gene expression Detailed, annotated, complexity field of slope stability and erosion control A holis- and fully tested protocols written by experienced tic approach to the revegetation of degraded slopes Contents SAGE researchers Interaction between substrate movement and vege- The role of metabolomics in systems biology.- An- tation discussed by geotechnical engineers, hydrol- alytical methods from the perspective of method Contents ogists and plant biologists State of the art technical standardization.- Reporting standards.- The Golm Part 1: Experimental Procedures.- 1. SAGE and and modelling methods presented by engineers, biol- Metabolome Database: a database for GC-MS based LongSAGE.- 2. Robust-LongSAGE (RL-SAGE): an ogists and foresters metabolite profiling.- Reconstruction of dynamic improved LongSAGE method for high-throughput transcriptome analysis.- 3. aRNALongsAGE: SAGE network models from metabolite measurements.- Contents with Antisense RNA.- 4. SuperSAGE.- 5. Low Cost Toward metabolome-based 13C flux analysis: a uni- 1. Introduction to Ecotechnological Solutions; A. Medium Throughput Sanger Dideoxy-Sequencing.- versal tool for measuring in vivo metabolic activity.- Stokes, J.E. Norris, J.R. Greenwood. 2. An introduc- 6. DeepSAGE-Higher Sensitivity and Multiplexing Data acquisition, analysis, and mining: Integrative tion to types of vegetated slopes; J.E. Norris, J.R. of Samples Using a Simpler Experimental Protocol.- tools for discerning metabolic function in Saccha- Greenwood. 3. Hillslope proceses: mass wasting, 7. High-Resolution Genome-wide Mapping of Chro- romyces cerevisiae.- E. coli metabolomics: capturing slope stability and erosion; L.P.H. van Beek, L.H. matin Modifications by GMAT.- 8. 5'-and 3'-RACE the complexity of a "simple" model.- The [..] Cammeraat, V. Andreu, S.B. Mickovski, L. Dor- from LongSAGE tags.- Part 2: Tag Extraction and ren. 4. How vegetation reinforces soil on slopes; A. Fields of interest Analysis.- 9. Extraction and Annotation of SAGE Stokes, J.E. Norris, L.P.H. van Beek, T. Bogaard, L.H. Biochemistry, general; Bioinformatics; Cell Biology; tags using Sequence Quality [..] Cammeraat, S.B. Mickovski, A. Jenner, A. Di Io- Microbial Genetics and Genomics; Computer Appl. rio, T. Fourcaud. 5. Hazard assessment of vegetated in Life Sciences Fields of interest Human Genetics; Cell Biology; Biochemistry, general slopes; J.E. Norris, J.R. Greenwood, A. Achim, B.A. Target groups Gardiner, B.C. Nicoll, L.H. Cammeraat, [..] Biochemists, bioinformaticists, cell biologists, micro- Target groups Fields of interest biologists Biotechnologists, geneticists, clinical geneticists, biochemists, molecular and cell biologists Soil Science & Conservation; Environmental Man- Type of publication agement; Geotechnical Engineering; Forestry; Plant Reference work Type of publication Ecology; Landscape Ecology Contributed volume Target groups Due October 2007 Research scientists, Postgraduate level students and Due December 2007 Managers working in the areas of slope stability, 2008. XVI, 284 p. (Topics in Current Genetics, Vol. 18) Hardcover landslide mitigation techniques, erosion control, 2008. Approx. 230 p. 42 illus. (Methods in Molecular Biology, Vol. forestry, ecotechnology and environmental protec- 139,95 € 387) Hardcover tion. ISBN 978-3-540-74718-5 79,95 € Type of publication ISBN 978-1-58829-676-4 Contributed volume

Due December 2007

2008. Hardcover springer.com/booksellers Life Science 95

110,00 € J. O'Quigley, University of California, San Diego, CA, USA L. Olsson, Center for Microbial Biotechnology, Lyngby, Sweden ISBN 978-1-4020-6675-7 (Ed.) Proportional Hazards Regression Biofuels

The place in survival analysis now occupied by proportional hazards models and their generalizations is so large that it is no longer conceivable to offer a Features course on the subject without devoting at least half Covers trends in modern biotechnology All aspects of the content to this topic alone. This book focuses of this interdisciplinary technology, where knowl- on the theory and applications of a very broad class edge, methods and expertise are required from of models – proportional hazards and non-propor- chemistry, biochemistry, microbiology, genetics, tional hazards models, the former being viewed as chemical engineering and computer science, are a special case of the latter – which underlie modern treated More information as well as the electronic survival analysis. Unlike other books in this area the version available at springer.com emphasis is not on measure theoretic arguments for Contents stochastic integrals and martingales. Instead, while J.M. Otero, G. Panagiotou, L. Olsson: Fueling Indus- inference based on counting processes and the theo- trial Biotechnology Growth with Bioethanol.- M. ry of martingales is covered, much greater weight is Galbe, G. Zacchi: Pretreatment of Lignocellulosic placed on more traditional results such as the func- Materials for Efficient Bioethanol Production.- R.P. tional central limit theorem. Chandra, R. Bura, W.E. Mabee, A. Berlin, X. Pan, Features J.N. Saddler: Substrate Pretreatment: The Key to Ef- This text differs from most recent works in that it is fective Enzymatic Hydrolysis of Lignocellulosics?- mostly concerned with methodological issues rather S.T. Merino, J. Cherry: Progress and Challenges in than the analysis itself Enzyme Development of Biomass Utilization.- L. Vi- ikari, M. Alapuranen, T. Puranen, J. Vehmaanperä, Contents M. Siika-aho: Thermostable Enzymes in Lignocellu- Introduction.- Background: probability.- Back- lose Hydrolysis.- B. Hahn-Hägerdal, K. [..] ground: inference.- Background: survival analysis.- Marginal survival.- Regression models and subject Fields of interest heterogeneity.- Estimating equations.- Inference: Biotechnology; Process and Chemical Engineering; functions of the Brownian motion.- Inference: like- Biochemistry, general; Industrial and Production En- lihood.- Inference: counting processes.- Inference: gineering; Environmental Biotechnology small samples.- Inference: changepoint models.- Ex- Target groups plained variation.- Explained randomness.- Survival Libraries and scientists in biomedicine, biotechnol- given covariates.- Proofs of theorems, lemmas and ogy, biochemical/chemical engineering and applied corollaries. microbiology, university institutes, research groups Fields of interest in industry Statistics for Life Sciences, Medicine, Health Sciences Type of publication Target groups Reviews Researchers, graduate students Due October 2007 Type of publication Monograph 2007. XII, 368 p. Also available online. (Advances in Biochemical Engineering / Biotechnology, Vol. 108) Hardcover Due December 2007 259,00 € ISBN 978-3-540-73650-9 2008. Approx. 430 p. (Statistics for Biology and Health) Hardcov- er

64,95 € ISBN 978-0-387-25148-6 96 Life Science springer.com/booksellers

A.L. Osterman, Burnham Institute for Medical Research, La Jolla, CA, USA; S. Gerdes, Fellowship for Interpretation of Genomes, Burr Ridge, IL, USA (Eds.)

Microbial Gene Essentiality

Protocols and Bioinformatics

This book contains a comprehensive collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies, developed and presented by the leading groups in the field. In addition to wet-lab protocols, the book describes (i) statistical methods essential for planning successful large-scale essentiality screens, as well for data evaluation and analysis; (ii) in-silico prediction of gene essentiality using genome-scale reconstructed metabolic models; and (iii) data integration and comparative analysis in the context of genomic databases. All protocols follow the successful Methods in Molecular Biology™ series format, each offering an introduction outlining the principles behind the techniques, step-by-step instructions, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls, and are intended for both novice and expert scientists.

Features Comprehensive, up-to-date collection of all main strategies of experimental genome-scale gene essentiality analysis under one cover Contains detailed description of the procedures, discussion of potential difficulties and failures Chapters on statistical analysis of the generated datasets and their integration in- to existing genomic databases

Contents Overview of Whole Genome Essentiality Analysis.- Transposon-based strategies for the identification of essential bacterial genes.- Identification and analysis of essential genes in Haemophilus influenzae.- Transposon site hybridization TraSH. in Mycobac- terium tuberculosis.- Essential genes in the infection model of P.aeruginosa PCR-based signature-tagged mutagenesis.- Whole-genome detection of condi- tionally essential and dispensable genes in E. coli via genetic footprinting.- Generating a Collection of In- sertion Mutations in the S. aureus Genome Using bursa aurealis.- Multipurpose [..]

Fields of interest Cell Biology; Human Genetics

Target groups Molecular and cellular biologists, molecular geneticists, bioinformaticians

Type of publication Contributed volume

Due November 2007

2008. Approx. 400 p. (Methods in Molecular Biology, Vol. 416) Hardcover

92,95 € ISBN 978-1-58829-378-7 springer.com/booksellers Life Science 97

N.H. Packer, Proteome Systems (Ed.) S.W. Paddock, University of Wisconsin, Madison, WI (Ed.) C. Pahl-Wostl, University of Osnabrueck, Germany; P. Kabat, Al- terra-ILRI, Wageningen, The Netherlands; J. Möltgen, University of Osnabrueck, Germany (Eds.) Glycomics Confocal Microscopy

Methods and Protocols Adaptive and Integrated Water Management Fields of interest Coping with Complexity and Uncertainty Biochemistry, general Fields of interest Type of publication Biochemistry, general Contributed volume Sustainable water management is a key environmen- Target groups tal challenge of the 21st century. Developing and im- Cell and Molecular Biologists; Histochemists/His- plementing innovative management approaches and Due October 2008 tologists; Developmental Biologists; Immunologists; how to cope with the increasing complexity and un- Neurobiologists; certainties was the theme of the first International 2008. 400 p. (Methods in Molecular Biology, Preliminary entry Conference on Adaptive and Integrated Water Man- 2074) Hardcover Type of publication Contributed volume agement, held in November 2007 in Basel, Switzer- 74,95 € land. The conference volume includes selected con- ISBN 978-1-58829-774-7 tributions on conceptual and methodological inno- Due October 2008 vations and empirical insights from case studies on important themes such as multi-level governance, 2008. Approx. 410 p. (Methods in Molecular Biology, Preliminary change management, vulnerability assessment, en- entry 2020) Hardcover vironmental flows, uncertainty analysis and the impacts of climate change. The book addresses a wide 74,95 € interdisciplinary audience of scientists and profes- ISBN 978-1-58829-351-0 sionals from academia, industry, and involved in policy making.

Features Presents the very latest studies, methods and innovations for managing our water resources from the first International Conference on Adaptive and Integrat- ed Water Management

Fields of interest Hydrogeology; Environmental Management; Politi- cal Science; Waste Water Technology / Water Pollu- tion Control / Water Management / Aquatic Pollu- tion; Sociology; Environmental Economics

Target groups Scientists; libraries, institutes; researchers

Type of publication Monograph

Due November 2007

2008. XIV, 440 p. 72 illus. Hardcover

129,95 € ISBN 978-3-540-75940-9 98 Life Science springer.com/booksellers

A. Panchenko, National Institutes of Health, Bethesda, MD, USA; A. Pandey, Johns Hopkins University, Baltimore, MD, USA (Ed.) V.K. Pasupuleti, Sai International, Geneva, USA (Ed.) T. Przytycka, National Institutes of Health, Bethesda, MD, USA (Eds.) Signal Transduction Protein Hydrolysates in

Protein-protein Interactions and A Systems Biology Approach Biotechnology Networks

Identification, Analysis and Prediction Signal Transduction: A Systems Biology Approach The protein hydrolysates industry is growing rapid- presents readers with an introduction to systems bi- ly yet there is no single book that describes the chal- ology as well as to provide details of approaches and lenges and opportunities for manufacturers and end This book integrates different approaches from methods in use today to study signal transduction users, techniques used in manufacturing, charac- bioinformatics, biochemistry, computational analy- from a systems biology perspective. This text takes terization and screening of protein hydrolysates, sis and systems biology to offer the reader a global DNA microarrays, proteomics methods and in vivo their applications in a wide variety of industries in view of the diverse data on protein-protein interac- methods and discusses them individually along with biotechnology. One of the misconceptions in using tions and protein interaction networks. Protein-pro- other chapters that will synthesize how the informa- protein hydrolysates in fermentations is that the end tein interactions and networks: identification, anal- tion derived from these methods can be more effec- user believes and uses it as a mere nitrogen source. ysis and prediction brings together the descriptions tively utilized and integrated. However, the functionality of the product obtained of experimental techniques and expounds on differ- is not necessarily due to protein hydrolysates alone ent computational algorithms for protein network Fields of interest because it may not be a pure peptide or a combi- analysis and prediction of protein and domain in- Cell Biology nation of peptides and may contain carbohydrates, teractions. Each chapter contains a description of lipids, micronutrients, etc., present in the raw mate- Type of publication the problem, a review of methods and algorithms, rial used or sometimes the manufacturers deliberate- Contributed volume a list of online resources, conclusions and future di- ly add to the process to bring unique functionality. rections. Offering broad coverage on the topic, this Only a handful of manufacturers dictate this market book will be of interest to researchers from academia Due August 2008 that tend to keep manufacturing process proprietary and the bioinformatics industry. The book will also making it harder to understand. This book will close the gap by unfolding information on [..] be of use to graduate students studying the topic. 2008. Approx. 350 p. Hardcover

Features 99,95 € Features Integrates different approaches which contribute to ISBN 978-1-58829-487-6 First book to describe the techniques used in manu- the understanding of the most recent advances in the facturing of protein hydrolysates and their applica- field of protein-protein interactions and protein in- tion Information on latest developments by the pro- teraction networks Includes a review of experimen- tein hydrolysate manufacturers and its end users It tal techniques, databases and various computational is hoped that information described in this book will methods for prediction and analysis of protein inter- lead to further understanding of protein hydrolysat- actions and their networks Provides comprehensive ed manufacturing and applications in general. coverage Contents Contents 1.Applications of Protein Hydrolysates in Biotech- Experimental Methods of Protein Interaction Identi- nology; V.K. Pasupuleti.- 2.State of the art of Manu- fication.- Protein and Domain Interaction Databas- facturing of Protein Hydrolysates; V .K. Pasupuleti es.- Protein Recognition, Binding Hot Spots.- Com- et al.- 3. Characterization and Screening of Protein putational Methods to Predict Protein Interaction Hydrolysates for Biopharmaceutical production; J. Partners.- Prediction of Domain-domain Interac- Wannlund et al.- 4. Benefits and Limitations of Pro- tions.- Characterization of the Structures of Macro- tein Hydrolysates as components of serum free me- molecular Assemblies.- Topological Properties of dia for Animal Cell Culture; J.L. Alfonso et al.- 5. Protein Interaction Networks.- Prediction of Protein Oligopeptides as external molecular signals affecting Function from Protein Interaction Networks.- Com- growth and death in animalcells; F. Franek.- 6. Use parison of Protein Interaction Networks and their of Protein Hydrolysates in Industrial Starter Culture Conservation in Evolution Fermentations; M. Ummadi [..]

Fields of interest Fields of interest Computational Biology/Bioinformatics; Bioinfor- Biotechnology; Plant Sciences; Nutrition; Animal matics; Computer Appl. in Life Sciences Biochemistry

Target groups Target groups Researchers in academia and industry Researchers and graduates working in the fields of commercial fermentations, biotechnology, crop nu- Type of publication trition, agriculture, chemical enzymes Contributed volume Type of publication Contributed volume Due May 2008

Due October 2007 2008. Hardcover

66,95 € 2008. Approx. 260 p. Hardcover ISBN 978-1-84800-124-4 100,00 € ISBN 978-1-4020-6673-3 springer.com/booksellers Life Science 99

A.H. Paterson, University of Georgia, Athens, GA, USA (Ed.) L. Pavesi, Università di Trento, Povo, Italy; P.M. Fauchet, Universi- K. Pawlowski, University of Göttingen, Germany; W.E. Newton, ty of Rochester, NY, USA (Eds.) State University, Blacksburg, VA, USA (Eds.) Genetics and Genomics of Cotton Biophotonics Nitrogen-fixing Actinorhizal Symbioses A few members of the Gossypium (cotton) genus are cultivated for the production of elongated sin- More profound understanding of the nature of light and light-matter interactions in biology has enabled gle-celled fibers valued worldwide at about $20 bil- This book is the self-contained sixth volume of many applications in the biology and medical fields. lion annually at the farm gate, and which sustain one a comprehensive series on nitrogen fixation. It So a new discipline is born, namely biophotonics. of the world’s largest industries (textiles) with an an- presents the state-of-the-art in regards to acti- The aim of this book is to review the current state-of- nual worldwide economic impact of about $500 bil- norhizal symbioses. Like legumes, actinorhizal plants the-art of the field by means of authoritative chapters lion. In a number of ways, cotton production and form root nodules that host nitrogen-fixing soil bac- written by the world leaders of the respective fields. the textile industry are closely tied to petrochemi- teria. However, because the macrosymbionts are, Biosensors, biochips, optical tomography, optical mi- cal usage. At a practical level, cotton genomics offers with one exception, woody plants rather than crop crosurgery, photodynamics therapy, bioactivation both bio-based carbon sequestration alternatives to plants, actinorhizal symbioses are less well-known of gene, photobiology of skin, and nanobiophoton- petrochemical use, and improved sustainability of than legume symbioses to which they are phyloge- ics are each introduced and recent advances present- crop production. The Gossypium (cotton) also genus netically related. Actinorhizal plants come from eight ed. This book will be useful not only to doctors, biol- presents novel opportunities to advance our under- different families. They can grow on marginal soils ogists, physicists, chemists, materials scientists, and standing of the natural world and its organic evolu- by virtue of these symbioses and are used extensive- engineers but also to graduate students who are in- tion. In particular, the evolution of cultivated cottons ly in reforestation, soil reclamation, and desert agro- terested in these rapidly developing fields. from their wild ancestors has involved a fascinating forestry. The diversity of the involved host plants series of events that offer scientists the opportuni- poses a variety of challenges to the actinorhizal sym- ty to dissect the evolution of a novel organ, the ‘lint Features Deals with the basics and applicatioins of the most biosis and results in interesting strategies, for ex- fiber’, and also to unravel the consequences of poly- ample, to cope with the O2 dilemma or nutrient ploidy, both for the [..] advanced optical methods in biology and medicine for cancer diagnosis and treatement or gene analy- exchange between plant and bacterium. The actinorhizal micro-symbionts are Gram-positive actino- Features sis Written for researchers and medical practi- mycetes of the genus Frankia. The inability to culture The first comprehensive reference on cotton ge- cioners in optical tomography, cancer treatment and [..] nomics The comprehensive genomic resource of research, ophtalmologists, surgeons, gene research and diagnosis But also appealing to biologists in pho- considerable interest to practicing plant biologists, Features tobiology as well as graduate students Offers many plant geneticists, graduate and undergraduate stu- Presents state-of-the-art information in regards to [..] dents, and research professionals such plant breeders actinorhizal symbioses Includes chapters dealing and germplasm curators who work on or are inter- with all aspects of the symbiosis and both symbionts ested in cotton Contents 1. Light conversion in photosynthetic organisms.- 2. plus their ecological role and use Discusses the global distribution of different actinorhizal plants and their Contents Exploiting photosynthesis for biofuel production.- microsymbionts Reference work for academic, gov- Taxonomy and Natural History of the diploid 3. In between photosynthesis and photoinhibition: ernmental and industrial scientists Volume provides Gossypiums.- Evolution and Radiation of the poly- The fundamental role of carotenoids and carotenoid- science administrators with a ready access [..] ploid Gossypiums.- The worldwide gene pool of binding proteins in photoprotection.- 4. Nonlinear microscopy.- 5. Applications of optical resonance to G. hirsutum.- The worldwide gene pool of G. bar- Contents biological sensing and imaging: Spectral self-inter- badense.- The worldwide gene pool of G. arboreum Preface to the Series, Preface, List of Contribu- ference microscopy.- 6. Applications of optical reso- and G. herbaceum.- Classical and molecular cytoge- tors, Dedication.1. Frankia and Actinorhizal Plants: nance to biological sensing and imaging: Resonant netics of Gossypium.- Classical and molecular genet- A Historical Perspective: C. T. Wheeler, A. D. L. cavity biosensors.- 7. Biodetection using silicon pho- ics of Gossypium.- Genetics of cotton fiber quality Akkermans, and A. M. Berry1. Introduction2. The tonic crystal microcavities.- 8. Optical coherence to- and development.- Genetics of cotton disease and in- Early Years3. Two Decades to the New Millenni- mography with [..] sect resistance.- Genetics of cotton abiotic stress tol- um4. PerspectivesReferences 2. Polyphasic Taxono- erance.- Gossypium DNA marker strategies and ap- my of the Genus Frankia: D. Hahn1. Introduction2. plications.- The Gossypium transcriptome.- The [..] Fields of interest Biophysics; Applied Optics, Optoelectronics, Optical Polyphasic Taxonomy Approach3. 16S-rRNA Se- quence Data4. DNA-DNA Relatedness5. 23S-rRNA Fields of interest Devices; Ophthalmology; General Surgery Sequence Data6. Genomic Fingerprinting7. Conclu- Plant Genetics & Genomics; Plant Pathology; Plant sionsReferences 3. Frankia Ecology: M. Valdés1. In- Biochemistry; Food Science Target groups Scientists, engineers and graduate students troduction2. Frankia as a Soil Microorganism3. Abi- Target groups otic Soil [..] Researchers, institutes, and professors in the follow- Type of publication Fields of interest ing areas: Plant Genetics and Genomics, Plant Biolo- Monograph Life Sciences, general; Agriculture; Plant Sciences gy, Plant Pathology, Agronomy, and Food Sciences Due February 2008 Target groups Type of publication University libraries (biological science), Research sci- Contributed volume 2008. Approx. 375 p. 200 illus. (Biological and Medical Physics, entists, Graduate students interested in biological ni- Biomedical Engineering) Hardcover trogen fixation, microbiology, plant-microbe inter- Due February 2008 ations, plant and soil sciences, ecology and the envi- 129,95 € ronment, Forestry and Biotechnology industries es- ISBN 978-3-540-76779-4 2008. Approx. 500 p. (Plant Genetics and Genomics: Crops and pecially in soil reclamation. Models, Vol. 3) Hardcover Type of publication 154,95 € Contributed volume ISBN 978-0-387-70809-6 Due October 2007

2008. XX, 312 p. (Nitrogen Fixation: Origins, Applications, and Research Progress, Vol. 6) Hardcover

129,00 € ISBN 978-1-4020-3540-1 100 Life Science springer.com/booksellers

M.J. Peirce, Imperial College School of Medicine, London, UK; R. S. Perez, Centre National de la Recherche Scientifique, Grenoble, R.D. Perry, University of Kentucky, Lexington, KY, USA; J.D. Wait, Imperial College School of Medicine, London, UK (Eds.) France (Ed.) Fetherston, University of Kentucky, Lexington, KY, USA (Eds.)

Membrane Proteomics Glycobioinformatics The Genus Yersinia

From Genomics to Function

This book provides a comprehensive collection of methods for extraction and purification of mem- Contents The 9th International Symposium on Yersinia was brane proteins from prokaryotic and eukaryotic or- Nomenclature and representation.- Shapes of held in Lexington, Kentucky, USA on October 10-14, ganisms, and also includes protocols for the mem- monosaccharides.- Disaccharides.- Oligosaccha- 2006. Over 250 Yersinia researchers from 18 coun- branes of subcellular organelles including mitochon- rides.- Exploring the hyper space (Monte Carlo).- tries gathered to present and discuss their research. dria, the Golgi apparatus and nuclei. Exploring the hyper space (Heuristic approach: CI- CADA).- .- Exploring the hyper space (Genetic Al- In addition to 37 oral presentations, there were 150 Fields of interest gorithmn).- Exploring the hyper space (Molecular poster presentations. This Symposium volume is Proteomics; Cell Biology Dynamics).- NMR and Molecular modeling.- Hydra- based on selected presentations from the meeting tion.- Protein-Carbohydrate interactions: docking.- and contains both reviews and research articles. It Type of publication Protein-AB interactions.- QSAR methods.- Glycan is divided into six topic areas: 1) genomics; 2) struc- Contributed volume Graphical Representations.- Structural analysis of ture and metabolism; 3) regulatory mechanisms; 4) carbohydrates.- Data bases of 3D structures of carbo- pathogenesis and host interactions; 5) molecular epi- Due August 2009 hydrates.- Predictions of Glycosylation positions in demiology and detection; and 6) vaccine and antimi- [..] crobial therapy development. Consequently, this volume covers a wide range of current research areas in 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Fields of interest the Yersinia field. entry 2248) Hardcover Bioinformatics Features 76,65 € Type of publication This volume present the latest research results in the ISBN 978-1-60327-309-1 Contributed volume field of Yersinia Proceedings from the 9th Interna- tional Symposium on Yersinia was held in Lexing- Due February 2009 ton, Kentucky, USA on October 10-14, 2006 The meeting that this volume is based on only occurs ever 4 years, so the information that it present demon- 2009. (Methods in Molecular Biology, Preliminary entry 2210) strates huge advances in the area The chapters are by Hardcover recognized researchers from around the globe, allow- 76,65 € ing the [..] ISBN 978-1-60327-000-7 Contents Comparative Genome Analyses of the Pathogenic Yersiniae Based on the Genome Sequence of Yersinia enterocolitica Strain.- Pestoides F, an Atyp- ical Yersinia pestis Strain from the Former Sovi- et Union .- Variability of the Protein Sequences of LcrV Between Epidemic and Atypical Rham- nose-Positive Strains of Yersinia pestis .- A New As- set for Pathogen Informatics – the Enteropathogen Resource Integration Center (ERIC), an NIAID Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Disease.- My Life with Yersinia.- Structure and Assembly of Yersinia pestis F1 [..]

Fields of interest Microbiology; Medical Microbiology; Infectious Dis- eases

Target groups Bacteriology/Microbiology, Public Health, and Bio- chemistry

Type of publication Contributed volume

Due October 2007

2007. XXIV, 432 p. 242 illus., 2 in color. (Advances in Experimental Medicine and Biology, Vol. 603) Hardcover

114,95 € ISBN 978-0-387-72123-1 springer.com/booksellers Life Science 101

F. Petersen, Novartis Pharma AG, Basel, Switzerland; R. Amstutz, L. Pettersson, University of Bergen, Norway; D. Durand, Universi- D. Pflieger, Laboratoire de Neurobiologie et Diversite Cellulaire, Novartis Pharma AG, Basel, Switzerland (Eds.) ty of Bergen, Norway; O. Johannessen, University of Bergen, Nor- Paris, France; J. Rossier, Laboratoire de Neurobiologie et Diversite way; D. Pozdnyakov, St. Petersburg, Russia Cellulaire, Paris, France (Eds.) Natural Compounds as Drugs, Volume I Monitoring of Harmful Algae Organelle Proteomics Blooms

This book starts with a chapter by Dr. Edwin Romijn The use of substances derived from plants, fungi, and Prof. John R. Yates III, who introduce the differ- bacteria and marine organisms has a long tradition Sometimes known as “Red Tides”, some of the wide ent analytical strategies developed and successfully in medicine. Together with their derivatives, and variety of phytoplankton species in the World’s utilized to study organelle proteomes, and detail the synthetic compounds deduced from natural prod- oceans produce toxins which can harm marine life. use of multidimensional liquid chromatography cou- uct precursors, they represent a major part of today's In certain circumstances, these harmful algae blooms pled to tandem mass spectrometry for peptide sam- pharmaceutical market. In molecular biological re- can even cause illness or death in humans. Shellfish ple analysis. This book is further composed of two search, natural products also play an important role filter feed on phytoplankton and concentrate their main sections. First, detailed protocols are provided as tool compounds in pathway screening and valida- toxins in their bodies and people who eat them can to perform the purification of the various organelles tion of target identification concepts. They provide contract life threatening food poisoning. A number present in eukaryotic cells, as well as to prepare cer- innovative opportunities in drug discovery, leading of countries have monitoring programmes to mea- tain sub-fractions of organelles (chapters 2-22). In to a detailed understanding of biological pathways sure the presence of toxins in algae blooms. Moni- all cases, the samples are aimed to be analyzed by a and revealing the functions of involved enzymes or toring of Harmful Algae Blooms is all about the re- mass spectrometry technique. While an exhaustive receptors. This book highlights the biodiversity-driv- search techniques to monitor visible algae blooms list of chapters covering all the proteomic analyses of en approaches which are now of eminent impor- and through remote sensing, including infrared tech- organelles and organelle fractions was not conceiv- tance in natural products research. It addresses the niques, predict them through mathematical mod- able, we nevertheless wanted to provide analysis ex- question why natural products display such a com- elling. amples reflecting the trend toward more specific pu- plex chemical information, what makes them often rifications of organelle sub-fractions, which will al- unique and what their characteristics are. Practical Features low reaching the more comprehensive and accurate questions such as supply of natural substances and Drawing on current and future satellite data presents characterization of the [..] production optimization strategies are also covered. visible perspectives of a more efficient HAB monitoring system for the future Emphasises practical Features Features applications, impacting on marine ecology, nation- Collects time tested reproducible laboratory proto- Highlights innovative opportunities in drug discov- al economy, health, food and safety and quality as- cols including tricks and hints written by experts in ery Overview of strategies and screening methods surance Using remote sensing and ecological/bio- the field Currently the only book that examines or- Compilation of current applicable technology chemical numerical modelling for data assimilation ganelle proteomics in depth as techniques for predicting HAB Contents Contents Mother nature's gifts to diseases of man: The im- Contents Analysis of organelles by on-line two-dimensional pact of natural products on anti-infective, antic- Aspects of Harmful Algae Blooms (HAB).- Biology liquid chromatography – tandem mass spectrometry holestemics and anticancer drug discovery.- Drug and ecology of some harmful algae species (focus on (2DLC-MS/MS).- Purification and proteomic anal- discovery and development with plant-derived com- Chantonella-tbd).- Retrieval of algae bloom relat- ysis of chloroplasts and their sub-organellar compounds.- Evolutionary mechanisms underlying sec- ed quantities from space.- Monitoring algae bloom partments.- Proteomic analysis of the stacked Gol- ondary metabolite diversity.- Biodiversity, chemical from space.- Integrated approach for operational and gi complex.- Purification of Saccharomyces cerevisi- diversity and drug discovery.- High impact technolo- forecasting HAB events.- Outlook. ae mitochondria by zone-electrophoresis in a free gies for natural products screening.- Virtual screen- flow device (ZE-FFE).- Preparation of Respiratory ing for the discovery of bioactive natural products.- Fields of interest Chain Complexes from Saccharomyces cerevisiae Strain improvement for production of pharmaceu- Monitoring/Environmental Analysis/Environmen- Wild Type and Mutant Mitochondria: Activity Mea- ticals and other microbial metabolites by fermenta- tal Ecotoxicology; Biogeosciences; Geochemistry; surement and Subunit Composition Analysis.- Mito- tion.- Nutritional and engineering aspects of [..] Oceanography; Geoinformation/Cartography; Ecol- ogy chondrial proteomics: Analysis of a whole mitochon- Fields of interest drial [..] Pharmacology/Toxicology; Biochemistry, general Target groups Scientists, researchers; libraries (oceanography, Fields of interest Target groups geoinformation, ecology, marine biology, environ- Proteomics; Cell Biology; Biochemistry, general Scientists in medicinal chemistry, pharmacologists, mental sciences, remote sensing) Target groups managers in the pharmaceutical industry Type of publication Molecular and cellular biologists, biochemists, and Type of publication Monograph proteomics specialists Monograph Type of publication Due January 2008 Contributed volume Due December 2007 Jointly published with Praxis Publishing, UK Due March 2008 2008. Approx. 350 p. (Progress in Drug Research, Vol. 65) Hard- cover 2008. Approx. 300 p. (Geophysical Sciences) Hardcover 2008. Approx. 491 p. 21 illus. (Methods in Molecular Biology, Vol. 432) Hardcover 189,00 € 99,95 € ISBN 978-3-7643-8098-4 ISBN 978-3-540-22892-9 79,95 € ISBN 978-1-58829-779-2 102 Life Science springer.com/booksellers

G. Pifat-Mrzljak, Rudjer Boškovic Institute, Zagreb, Croatia (Ed.) V. Polunovsky, University of Minnesota, Minneapolis, MN, USA; F. Posas, Universitat Internacional de Catalunya, Barcelona, P.J. Houghton, St. Jude Children's Research Hospital, Memphis, Spain; A.R. Nebreda, Spanish National Cancer Center, Madrid, TN, USA (Eds.) Spain (Eds.) Supramolecular Structure and Function 9 mTOR Pathway and mTOR Stress-activated Protein Kinases Inhibitors in Cancer Therapy

The book is based on International Summer Schools on Biophysics held in Croatia which, contrary to Fields of interest other workshops centered mainly on one topic or Biochemistry, general; Cell Biology Fields of interest technique, has very broad scope providing advanced Cancer Research; Cell Biology; Pharmacology/Toxi- training in areas related to biophysics. This volume is Type of publication cology presenting papers in the field of biophysics for study- Reference work ing biological phenomena by using physical methods Type of publication (NMR, EPR, FTIR, Mass Spectrometry, etc.) and/ Contributed volume Due January 2008 or concepts (predictions of protein-protein interactions, virtual ligand screening etc.). The interre- lationship of supramolecular structures and there Due February 2009 2008. Approx. 320 p. (Topics in Current Genetics, Vol. 20) Hard- cover functions is enlightened by applications of princi- pals of these physical methods in the biophysical and 2009. Approx. 250 p (Cancer Drug Discovery and Development) 159,95 € molecular biology context. Hardcover ISBN 978-3-540-75568-5 Features 107,05 € Biophysical knowledge is presented by prominent ISBN 978-1-60327-270-4 lecturers It follows the state-of-art problem-oriented and/or methodology oriented approaches to study biological systems Its broad scope should be of interest not only for students at doctoral or postdoctoral level but to experienced scientists as well

Contents Predictions of Protein-Protein Interactions at the Atomic Scale.- An Infrared Study of Fibril Forma- tion Insulin from Different Sources.- Some Basic Biomolecular NMR from Protein Structure Determi- nation.- Solid State NMR for Studying Membrane Proteins.- Protein Complexes in SUMO Signaling. -Mass Spectrometry and Glycomics.- Mechanisms of Supramolecular Assembly Exemplified by Micro- tubules and Amyloid Fibril Formation.- Hepatitis B-Virus (HBV): The Life-cycle and Assembly of a Complex Virus.- Photo-oxidative Stress in the Pres- ence of a Water-soluble Derivative of C60: ESR and AFM Assays.- [..]

Fields of interest Biophysics; Bioinformatics; Solid State Physics and Spectroscopy; Cancer Research

Target groups Doctoral fellows, educators in biophysics at biophysical or molecular biology departments; participants (and members) of Biophysics Congresses (and So- cieties) – international (IUPAB), European (EBSA) and national; life sciences doctoral and/or postdoctoral scientists at universities, institutes and (pharmaceutical) industry

Type of publication Contributed volume

Due October 2007

2008. Approx. 330 p. Hardcover

99,95 € ISBN 978-1-4020-6465-4 springer.com/booksellers Life Science 103

A. Posch (Ed.) A. Posch, Grafing, Germany M. Poulin, University of Calgary, AB, Canada; R. Wilson, University of Calgary, AB, Canada (Eds.) 2D PAGE: Sample Preparation and 2D PAGE: Sample Preparation and Fractionation Fractionation Integration in Respiratory Control From Genes to Systems Volume 2 Volume 1

The neuronal circuit that generates breathing, the This book presents a broad coverage of the princi- This book presents a broad coverage of the princi- regulation of breathing, and its integration with oth- ples and recent developments of sample preparation ples and recent developments of sample preparation er physiological systems is of utmost importance to and fractionation tools in Expression Proteomics in and fractionation tools in Expression Proteomics in human health. However, breathing abnormalities are general and for two-dimensional electrophoresis (2- general and for two-dimensional electrophoresis (2- common, and sleep apnea alone is estimated to affect DE) in particular. 2-DE, with its unique capacity to DE) in particular. 2-DE, with its unique capacity to 18 million in the United States. As one of the major resolve thousands of proteins in a single run, is still resolve thousands of proteins in a single run, is still complications of obesity, the prevalence of sleep ap- a fundamental research tool for nearly all protein-re- a fundamental research tool for nearly all protein-re- nea is likely to increase in the coming years. Con- lated scientific projects. The methods described here lated scientific projects. The methods described here genital central hypoventilation syndrome (CCHS), in detail are not limited to 2-DE and can also be ap- in detail are not limited to 2-DE and can also be ap- asthma, Parkinson's disease, multiple sclerosis, spinal plied to other protein separation techniques. plied to other protein separation techniques. cord injury, and the pathophysiology of panic and Features Features related anxiety states also involve aspects of respi- Contains step-by-step instructions that ensure suc- Contains step-by-step instructions that ensure suc- ratory control. Integration in Respiratory Control: cessful results Provides tricks of the trade and notes cessful results Provides tricks of the trade and notes From Genes to Systems comprises the proceedings of on troubleshooting and avoiding known pitfalls on troubleshooting and avoiding known pitfalls the 10th Oxford Conference held at Lake Louise, Al- berta, Canada, from the 19th to the 24th of Septem- Contents Contents ber, 2006. This series of meetings was originally be- Application of fluorescence dye saturation labelling Mechanical/Physical Methods of Cell Disruption and gun to bring physiologists and mathematicians to- for differential proteome analysis of 1000 microdis- Tissue Homogenization.- Bacteria and yeast cells gether, in order to address critical issues in under- sected cells from pancreatic ductal adenocarcino- disruption using lytic enzymes.- Sample solubiliza- standing the control of breathing. [..] ma precursor lesions.- Albumin and immunoglobu- tion buffers for two-dimensional electrophoresis.- lin depletion of human plasma.- Multi-component Quantitation of protein in samples prepared for 2-D Features Immunoaffinity Subtraction and Reversed-phase electrophoresis.- Removal of Interfering Substances Contains the most up-to-date research in cardio-res- Chromatography of Human Serum.- Immunoaffini- in Samples Prepared for 2-D Electrophoresis.- Pro- piratory control Content spans the disciplines of res- ty Fractionation of Plasma Proteins by Chicken IgY tein Concentration by Hydrophilic Interaction Chro- piratory physiology, neurobiology, modeling, and Antibodies.- Proteomics of Cerebrospinal Fluid: matography combined with Solid Phase Extraction.- biomedical engineering Will be of interest to clini- Methods for Sample Processing.- Sample Prepara- Difference Gel Electrophoresis Based on Lys/Cys cians working with patients with breathing disorders tion of Bronchoalveolar Lavage Fluid.- Preparation Tagging.- Isotope-coded two-dimensional maps: tag- Contents of nasal secretions for proteome analysis.- Prepara- ging with deuterated acrylamide and 2- [..] Preface.- Part I: Historical and Future Perspectives tion of [..] Fields of interest of the Control of Breathing.- Part II: Oxygen Sensing Fields of interest Proteomics; Cell Biology; Biochemistry, general; Mi- and the Carotid Body.- Part III: Respiratory Rhythm Proteomics; Cell Biology; Biochemistry, general; Mi- crobial Genetics and Genomics Generation.- Part IV: Genes and Development.- Part crobial Genetics and Genomics V: Models of Gas Exchange.- Part VI: Plasticity and Target groups Adaptation.- Part VII: Neuromodulation.- Part VIII: Target groups Biochemists, molecular and cellular biologists, and Comparative Aspects.- Part IX: Central Chemosen- Biochemists, molecular and cellular biologists, and protein scientists sitivity.- Part X: Brainstem Mechanisms Underly- protein scientists ing Cardio-Respiratory Control.- Part XI: Multifunc- Type of publication tional and Reconfiguring Networks.- Part XII: Clini- Type of publication Contributed volume cal Perspectives: Modeling and Control of Breathing Contributed volume (i.e., Sleep Apnea).- [..] Due December 2007 Fields of interest Due December 2007 Neurobiology; Pathology; Neurosciences; Molecu- 2008. Approx. 554 p. 131 illus. 2 in color. (Methods in Molecular lar Medicine; Genetic Engineering; Biomedical Engi- 2008. 455 p. 83 illus., 3 in color. (Methods in Molecular Biology, Biology, Vol. 424) Hardcover neering Vol. 425) Hardcover 92,95 € Target groups 92,95 € ISBN 978-1-58829-722-8 Physiologists, clinicians, mathematicians, neurobiol- ISBN 978-1-60327-209-4 ogists, modelers, biomedical engineers, graduate students

Type of publication Contributed volume

Due December 2007

2008. Approx. 450 p. (Advances in Experimental Medicine and Biology, Vol. 605) Hardcover

124,95 € ISBN 978-0-387-73692-1 104 Life Science springer.com/booksellers

T.D. Price, University of Wisconsin, Madison, WI, USA; G.M. Fein- H.H.T. Prins, Resource Ecology Group, Wageningen University, H.H.T. Prins, Resource Ecology Group, Wageningen University, man, Field Museum, Chicago, IL, USA (Eds.) The Netherlands; F.v. Langevelde, Resource Ecology Group, Wa- The Netherlands; F.v. Langevelde, Resource Ecology Group, Wa- geningen University, The Netherlands (Eds.) geningen University, The Netherlands (Eds.) Archaeology at the Millennium Resource Ecology Resource Ecology A Sourcebook Spatial and Temporal Dynamics of Foraging Spatial and Temporal Dynamics of Foraging

An internationally distinguished roster of contributors considers the state of the art of the discipline of This multi-author book deals with ‘resource ecolo- archaeology at the turn of the 21st century and charts gy’, which is the ecology of trophic interactions be- Features an ambitious agenda for the future. The chapters ad- tween consumers and their resources. Resource ecol- Coherent set of chapters dealing with resource ecol- dress a wide range of topics including paradigms, ogy is perhaps the most central part of ecology. In ogy (ideal for lecturers developing a new course on practice, and relevance of the discipline; paleoan- its linkage between foraging theory and spatial ecolo- resource ecology)Every chapter has testable hypothe- thropology; fully modern humans; holocene hunter- gy, it shows how old and fundamental questions can ses for further research (ideal for students, especial- gatherers; the transition to food and craft produc- be tackled afresh. It addresses crucial aspects of the ly PhD students looking for good subjects for their tion; social inequality; warfare; state and empire for- interactions between consumers and resources. For- theses)Ample attention for the emerging issue in mation; and the uneasy relationship between classi- aging is the central process in resource ecology be- ecology of ‘scale’ cal and anthropological archaeology. cause it leads to growth, survival and reproduction of the animal. Resource ecology forms the basis for Contents Features comprehending the functioning of multi-species as- Preface.- 1.Introduction on resource ecology.- 2A. Written by world-renowned archaeologists Each semblages, and is thus key to grasp the organisation Mechanisms determining large-herbivore distribu- chapter discusses the hot topics in turn-of-the-mil- of biodiversity. All chapters in the book were pre- tion.- 2B. Comments on "Mechanisms determining lennium archaeology Suitable for advanced archaeol- pared for a small symposium and were circulated in large-herbivore distribution.- 3A. Spatial statistics ogy courses advance to the participants. They were subjected to to quantify patterns of herd dispersion in a savan- intense group discussions; comments and critiques na herbivore community.- 3B. Comments on "Spa- Contents were subsequently used for writing new versions, tial statistics to quantify patterns of herd dispersion Foreword.- Archaeology at the Millennium: Of which were peer-reviewed. For the purposes of stim- in a savanna herbivore community.- 4A. Resource Paradigms and Practice.- An Aspect of Archaeology's ulating future research, each chapter ends [..] distribution and dynamics: mapping herbivore re- Recent Past and Its Relevance in the New Millenni- sources.- 4B. Comments on "Resource distribution um.- Paleoanthropology at the Millennium.- Ful- Features and dynamics:mapping herbivore resources".- 5A. ly Modern Humans.- Holocene Hunter-Gather- Coherent set of chapters dealing with resource ecol- Foraging in a heterogeneous environment: intake ers.- The Transition to Food Production.- Richman, ogy (ideal for lecturers developing a new course on and [..] Poorman, Beggarman, Chief: The Dynamics of So- resource ecology)Every chapter has testable hypothe- cial Inequality.- Craft Production Systems.- Warfare ses for further research (ideal for students, especial- Fields of interest and the Evolution of Culture.- Understanding An- ly PhD students looking for good subjects for their Plant Sciences; Ecology cient State Societies in the Old World.- State Forma- theses)Ample attention for the emerging issue in Target groups tion in the New World.- Classical Archaeology and ecology of ‘scale’ Academia, active researchers3rd-year students (end Anthropological Archaeology in North America: A of bachelor, master)PhD students and post-docs Meeting of [..] Contents Preface.- 1.Introduction on resource ecology.- 2A. Type of publication Fields of interest Mechanisms determining large-herbivore distribu- Proceedings Archaeology; Anthropology tion.- 2B. Comments on "Mechanisms determining large-herbivore distribution.- 3A. Spatial statistics Target groups to quantify patterns of herd dispersion in a savan- Due January 2008 Advanced archaeology courses na herbivore community.- 3B. Comments on "Spa- tial statistics to quantify patterns of herd dispersion 2008. XII, 304p. (Wageningen UR Frontis Series, Vol. 23) Softcov- Type of publication in a savanna herbivore community.- 4A. Resource er Contributed volume distribution and dynamics: mapping herbivore resources.- 4B. Comments on "Resource distribution 48,00 € Due October 2007 and dynamics:mapping herbivore resources".- 5A. ISBN 978-1-4020-6849-2 Foraging in a heterogeneous environment: intake 2007. XVI, 512 p. Softcover and [..]

53,90 € Fields of interest ISBN 978-0-387-72610-6 Animal Ecology; Behavioural Sciences; Theoretical Ecology; Nature Conservation

Target groups Academia, active researchers 3rd-year students (end of bachelor, master) PhD students and post-docs

Type of publication Proceedings

Due January 2008

2008. XII, 304p (Wageningen UR Frontis Series, Vol. 23) Hardcov- er

96,00 € ISBN 978-1-4020-6848-5 springer.com/booksellers Life Science 105

D.J. Prockop, Tulane University Health Sciences Center, New Or- J. Prohens, Universidad Politecnica de Valencia, Spain; F. Nuez, J. Prohens, Universidad Politecnica de Valencia, Valencia, Spain; leans, LA, USA; D.G. Phinney, Tulane University Health Sciences Universidad Politecnica de Valencia, Spain (Eds.) F. Nuez, Universidad Politecnica de Valencia, Valencia, Spain Center, New Orleans, LA, USA; B.A. Bunnell, Tulane University (Eds.) Health Sciences Center, New Orleans, LA, USA (Eds.) Vegetables II Vegetables I Mesenchymal Stem Cells Fabaceae, Liliaceae, Solanaceae and Umbelliferae Asteraceae, Brassicaceae, Chenopodicaceae and Cucur- Methods and Protocols bitaceae

This first volume of the Handbook of Plant Breed- ing book series is devoted to vegetable crops breed- For over forty years, mesenchymal stem cells (MSCs) ing. Each chapter is dedicated to a major veg- This first volume of the Handbook of Plant Breeding have been scrutinized and studied, garnering much etable crop. Each chapter contains a comprehensive book series is devoted to vegetable crops breeding. attention due to their broad therapeutic efficacy. In review of the diversity, breeding techniques, achieve- Each chapter is dedicated to a major vegetable crop. Mesenchymal Stem Cells: Methods and Protocols, ments and use of the most advanced molecular tech- Each chapter contains a comprehensive review of the leaders in the field were assembled to contribute de- niques in the genetic improvement of these crops. diversity, breeding techniques, achievements and use tailed methodologies for the isolation and charac- The purpose of the book is to provide breeders and of the most advanced molecular techniques in the terization of human and rodent MSCs. Recently, researchers from the public and private sectors with genetic improvement of these crops. The purpose these vital cells have shown therapeutic benefits in updated information and the latest novelties in the of the book is to provide breeders and researchers the treatment of myocardial infarction, stroke, lung breeding of specific crops of economic relevance. Al- from the public and private sectors with updated in- diseases, spinal cord injury and other neurological so, it serves as a major reference book for post-grad- formation and the latest novelties in the breeding of disorders, thus promising a boundless future in their uate courses and PhD courses on breeding vegetable specific crops of economic relevance. Also, it serves study.Cutting edge and easy to use, Mesenchymal crops, as well a book of consult for horticulturists as a major reference book for post-graduate cours- Stem Cells: Methods and Protocols is the perfect re- and extension agents interested in current advance- es and PhD courses on breeding vegetable crops, as source for scientists attempting to pursue this impor- ments in the development of new vegetable crops va- well a book of consult for horticulturists and exten- tant and ever-developing field of research. rieties. Each chapter incorporates the most up-to- sion agents interested in current advancements in date information on the crops examined, and an im- the development of new vegetable crops varieties. Features portant novelty is that, in comparison to other books Each chapter incorporates the most up-to-date in- An essential guide to MSC research for both new- already published on this subject this [..] formation on the crops examined, and an important comers and established researchers in the field Con- novelty is that, in comparison to other books already tains chapters on isolation and expansion of mouse Features published on this subject this book [..] and human stem cells Explores stem cells from bone A comprehensive reference on major vegetable crops marrow and adipose tissue Provides procedures for The only complete resource for plant breeders that Features differentiation of stem cells along multiple lineages includes the most recent molecular techniques being A comprehensive reference on major vegetable crops used across species The only complete resource for plant breeders that Contents includes the most recent molecular techniques being Isolation and culture of bone marrow-de- Contents used across species rived human multipotent stromal cells (hM- Preface.- Family Fabaceae (=Leguminosae): Gar- SCs).- Mesenchymal stem cells from adult den Pea.- Snap Bean.- Family Liliaceae: Asparagus.- Contents bone marrow.- A method to isolate and Onion.- Family Solanaceae: Eggplant.- Pepper.- Preface.- Family Asteraceae (=Compositae): Chico- purify human bone marrow stromal stem cells.- Tomato.- Family Umbelliferae (=Apiaceae): Carrot.- ry and Endive.- Globe Artichoke and Cardoon.- Let- Adipose-derived stem cells.- Isolation of hu- Index. tuce.- Family Brassicaceae (=Cruciferae): Cabbage.- man adipose-derived stem cells from biopsies and Cauliflower and Broccoli.- Family Chenopodiaceae: liposuction specimens.- Colony forming unit as- Fields of interest Spinach.- Table Beet.- Family Cucurbitaceae: Cu- says for MSCs.- Differentiation and charac- Plant Genetics & Genomics; Plant Sciences; Agricul- cumber.- Melon.- Pumpkin and Winter Squash.- terization of human MSCs.- Freezing harvested hM- ture Summer Squash.- Watermelon.- Index. SCs and recovery of hMSCs from frozen vials for subsequent expansion, analysis and experimenta- Target groups Fields of interest tion.- Gene expression analysis at the [..] Plant breeders, researchers and as a suggested book Plant Genetics & Genomics; Plant Sciences; Agricul- in plant breeding courses ture Fields of interest Cell Biology; Molecular Medicine; Immunology Type of publication Target groups Reference work Plant breeders, researchers and as a suggested book Target groups in plant breeding courses Stem cell biologists, molecular and cellular biologists Due January 2008 Type of publication Type of publication Reference work Contributed volume 2008. Approx. 405 p. (Handbook of Plant Breeding, Vol. 2) Hard- cover Due January 2008 Due May 2008 114,95 € ISBN 978-0-387-74108-6 2008. Approx. 430 p. 78 illus., 11 in color. (Handbook of Plant 2008. Approx. 220 p. 34 illus. 7 in color (Methods in Molecular Breeding, Vol. 1) Hardcover Biology, Vol. 449) Hardcover 114,95 € 76,95 € ISBN 978-0-387-72291-7 ISBN 978-1-58829-771-6 106 Life Science springer.com/booksellers

V.K. Rajasekhar, Memorial Sloan-Kettering Cancer Center, New T. Ramamurthy, National Institute of Cholera and Enteric Dis- K.G. Ramawat, University of Udaipur, India; J.M. Merillon, Univer- York, NY, USA; M.C. Vemuri, Invitrogen Corporation, Grand Island, eases, Calcutta, India (Ed.) sity of Bordeaux, France (Eds.) NY, USA (Eds.) Cholera Bioactive Molecules and Medicinal Regulatory Networks in Stem Cells Molecular and Epidemiological Aspects Plants

Contents This book on medicinal plant biotechnology covers Genetic control of stem cell identi- Fields of interest recent developments in this field including a com- ty.- Transcriptome in ES cells.- Post- Infectious Diseases; Microbiology prehensive up to date survey on established medic- transcriptional controls in ES cells.- Signaling inal plants and on molecules which gained impor- Type of publication networks in ES cells.- Self renewal mech- tance in recent years. The contributing scientists Contributed volume anisms in ES cells.- Nuclear reprogram- have been selected on the basis of their involvement ming.- Epigenome in stem cells.- DNA in the related plant material as evident by the in- methylation in Stem Cells.- Micro RNAs in Due August 2008 ternationally recognised published work. Bioactive stem cells.- Differentiation specific gene ex- molecules such as taxol, classes of compounds such as phytoestrogen and plant materials such as ginseng pression in stem cells.- Pancreatic lineage-spe- 2008. Approx. 320 p. (Infectious Disease) Hardcover cific expression in stem cells.- Towards Car- have all been included. diomyocyte production.- Hematopoietic lin- 127,05 € Features eages.- Neural Stem Cells.- Myogenic ISBN 978-1-60327-264-3 No recent book covering these topics Medicinal differentiation.- Gene therapy [..] plants and their products are in demand and have Fields of interest gained importance in recent years Carefully selected Cell Biology; Developmental Biology; Neurobiology topics

Type of publication Contents Contributed volume A.A. Salim, Y.-W. Chin, A. D. Kinghorn: Drug Dis- covery from Plants.- P. Waffo-Teguo, K. Stephanie, R. Tristan, J.M. Merillon: Grapevine Stilbenes and Due June 2008 Biological Effects.- M.T. Luczkiewicz: Research into Isoflavonoid Phytoestrogens in Plant Cell Cultures.- 2008. Approx. 400 p. 75 illus. Hardcover S. Kintzios: Recent Advances in Secondary Metabo- lite Production from Plant Cell Culture: the Success- 111,65 € ful Case Stories of Rosmarinic Acid and Taxol.- K.G. ISBN 978-1-60327-226-1 Ramawat, M. Mathur, S. Dass, S. Suthar: Gugguls- terone: A Potent Natural Hypolipidemic Agent from Commiphora wightii- Problems, Perseverance and Prospects.- P. Corchete: Silybum [..]

Fields of interest Biotechnology; Plant Biochemistry; Medicinal Chemistry; Pharmacy

Target groups Academic research labs in the field of biotechnology, pharmacology, medicinal chemistry, phytochemistry, and plant biochemistry; scientists in the pharmaceutical industry

Type of publication Reference work

Due January 2008

2008. Approx. 300 p. Hardcover

199,95 € ISBN 978-3-540-74600-3 springer.com/booksellers Life Science 107

N.H. Ravindranath, Indian Institute of Science, Bangalore, India; R.J. Read, University of Cambridge, UK; J.L. Sussman, Weizmann B.M. Reed, USDA-ARS, Corvallis, OR, USA (Ed.) M. Ostwald, Linköping University, and Göteborg University, Swe- Institute of Science, Rehovot, Israel (Eds.) den Plant Cryopreservation Evolving Methods for Carbon Inventory Methods Macromolecular Crystallography A Practical Guide Handbook for Greenhouse Gas Inventory, Carbon Mitigation and Roundwood Production Projects The Structural Path to the Understanding of the Mechanism of Action of CBRN Agents Plant Cryopreservation: A Practical Guide is a unique resource for plant scientists in many fields. This compilation provides over 100 ready-to-use Features X-ray crystallography is the pre-eminent technique protocols for plant types from algae and bryophytes Unique since it is driven for a clearly identified need for visualizing the structures of macromolecules at to a range of flowering plants. It includes techniques and a growing need for ‘carbon inventory’ for land atomic resolution. These structures are central to for diverse plant parts such as dormant buds, pollen, use sections such as forests Provides practical guid- understanding the detailed mechanisms of biolog- and apical meristems, and for cell types such as sus- ance, in a user-friendly way, on methods, tools and ical processes, and to discovering novel therapeu- pension and callus cultures. Five introductory chap- techniques, together with examples tics using a structure-based approach. As yet, struc- ters describe theoretical principles, practical aspects tures are known for only a small fraction of the pro- of long-term cryopreserved storage, and details of Contents teins encoded by human and pathogenic genomes. the main cryopreservation techniques. The remain- From the contents 1 Introduction.- 2. Global Carbon To counter the myriad modern threats of disease, ing 14 chapters are separated by plant type. Each Cycle, Carbon Dioxide Emissions and Mitigation.- there is an urgent need to determine the structures chapter briefly reviews the literature and includes 3 Categories of Activities, Programmes and Projects of the thousands of proteins whose structure and ready-to-use protocols designed for easy transfer in- Requiring Carbon Inventory.- 4 Carbon Pools and function remain unknown. This volume draws on to the lab and adaptation to new species. Measurement Frequency for Carbon Inventory.- 5 the expertise of leaders in the field of macromolecu- Carbon Inventory in Project Development, Imple- lar crystallography to illuminate the dramatic devel- Features mentation and Monitoring Phases.- 6 Methodologi- opments that are accelerating progress in structural Provides a practical guide to cryopreservation tech- cal Issues in Land-Based Projects.- 7 Carbon Inven- biology. Their contributions span the range of techniques used across plant species Focuses on precise tory Under Baseline and Project Scenarios.- 8 Project niques from crystallization through data collection, protocols unlike its competition which are overview Area and Boundary Estimation.- 9 Generic Methods structure solution and analysis, and show how mod- books for Inventory of Carbon Pools.- 10. Methods for Es- ern high-throughput methods are contributing to a Contents timating Above-Ground Biomass.- 11 Methods for deeper understanding of medical problems. Introduction.- History and Theoretical Principles.- [..] Features Laboratory Facilities.- Cryopreservation of Plant Fields of interest Arises from the renowned Erice Schools on Macro- Cells, Tissues and Organs.- Differentiated Tissues.- Climate Change; Forestry; Environment, general molecular Crystallography Chapters by leading ex- Vegetative Tissue.- Seeds (Orthodox, Intermediate, perts in modern methods of macromolecular crystal- Recalcitrant).- Pollen.- Dormant Buds.- Associated Target groups lography Spans the range from detailed practical ad- Techniques.- Index. Forest management, climate change mitigation, envi- vice to advanced analytical techniques ronmental scientists Fields of interest Contents Plant Genetics & Genomics; Plant Sciences; Agricul- Type of publication Preface. Succeeding with Seeding: some practical ture Monograph Advice.- Expression, Purification and Crystallisa- Target groups tion of membrane Proteins.- Macromolecular Cryo- Researchers in all areas of plant transformation and Crystallography.- Processing Diffraction Data with Due November 2007 breeding, professors teaching advanced courses on Mosfim.- SAD Phasing: basic Concepts and High- plant breeding Throughput.- Likelihood-based experimental phas- 2007. Approx. 339 p. (Advances in Global Change Research, Vol. ing in Phaser.-Stochastic molecular Replacement.- 29) Hardcover Type of publication Likelihood-based molecular Replacement in Phaser.- Contributed volume 149,95 € Automated Structure Determination with PHENIX.- ISBN 978-1-4020-6546-0 Density Modification in MAIN.- Ab initio Phasing starting from Low Resolution.- Structural Genomics Due November 2007 of Mycobacterium tuberculosis - a Search for Func- tion [..] 2008. Approx. 480 p. 25 illus. Hardcover

Fields of interest 119,95 € Crystallography; Biophysics; Bioinformatics; Com- ISBN 978-0-387-72275-7 puter Appl. in Life Sciences

Target groups Crystallographers, graduate students, post-doctoral fellows

Type of publication Proceedings

Due October 2007

2007. VIII, 191 p. (NATO Science Series II: Mathematics, Physics and Chemistry, Vol. 245) Softcover

49,95 € ISBN 978-1-4020-6315-2 108 Life Science springer.com/booksellers

A. Reid, University of Bath, UK; B.B. Jensen, Danish University of R. Renneberg, University of Hong Kong; F. Lisdat, Wildau Univer- C. Richardson, Duke University, Durham, NC, USA Education, Copenhagen, Denmark; J. Nikel, University of Bath, sity (Eds.) UK; V. Simovska, Danish University of Education, Copenhagen, Denmark (Eds.) The Everglades Experiments Biosensing for the 21st Century Lessons for Ecosystem Restoration Participation and Learning

Perspectives on Education and the Environment, Health and Sustainability Features The Florida Everglades ecosystem is recognized Covers trends in modern biotechnology All aspects worldwide as a significant wetland whose natural of this interdisciplinary technology, where knowl- processes have been altered and remain threatened. State and Federal United States agencies face criti- This ground-breaking collection brings together edge, methods and expertise are required from cal decisions about the course of conservation and a diverse range of perspectives on the philosophy, chemistry, biochemistry, microbiology, genetics, restoration efforts. Synthesizing nearly ten years of design and experience of participatory approaches chemical engineering and computer science, are laboratory and field research of the Duke Univer- within education and the environment, health and treated More information as well as the electronic sity Wetland Center, The Everglades Experiments: sustainability. Chapters address participatory work version available at springer.com Lessons for Ecosystem Restoration, provides the with children, youth and adults in both formal and Contents long-term integrated scientific studies needed to un- non-formal settings. Authors combine reflections 1 R. Renneberg, D. Pfeiffer, F. Lisdat, G. Wilson, derstand the functioning of this region. The funda- on experience, models and case studies of partici- U. Wollenberger, F. Ligler, A.P.F. Turner: Frieder mental issues that the research addressed are: 1) The patory education with commentary on key debates Scheller and the Short History of Biosensors.- 2 effects of increased nutrients and water inputs on the and issues. The book will be a valuable resource for U. Wollenberger, R. Spricigo, S. Leimkühler, K. native plant and animal communities of the Ever- researchers and advanced students with interests Schröder: Protein Electrodes with Direct Electro- glades 2) The long-term nutrient storage capacity of in learning, research and key concepts in environ- chemical Communication.- 3 A. Lambrianou, S. the Everglades 3) The effects of changes in water lev- mental education, health education, and education Demin, E. Hall: Protein Engineering and Electro- el and hydroperiod on Everglades period and func- for sustainable development, and professionals and chemical Biosensors.- 4 B. Danielson: Artifi- tion 4) Management and restoration of the natural practitioners engaged in planning and evaluation. cial Receptors.- 5 C. P. Chan, Y. Cheung, R. communities of the Everglades. Features Renneberg, M. Seydack: New Trends in Immunoas- Features Ground-breaking collection bringing together a di- says.- 6 A. Warsinke: Electrochemical Biochips for Background information about current and histor- verse range of perspectives on the philosophy, design Protein Analysis.- 7 O. Pänke, T. Balkenhohl, J. Kaf- ical ecological conditions of the region set the con- and experience of participatory approaches within ka, D. [..] text for reports of long-term research projects. A se- education and the environment, health and sustain- Fields of interest ries of gradient studies determining the effects of hy- ability Chapters addressing participatory work in Biotechnology; Human Genetics; Molecular drology and nutrient changes are presented, followed both formal and non-formal settings Contains inter- Medicine; Medical Microbiology; Biochemistry, gen- by field experiments that have tested those findings. national case studies written by leading authorities eral Subsequent sections present models for predicting in participation, education, health, environment, and responses to various conditions and analyze the [..] [..] Target groups Libraries and scientists in biomedicine, biotechnol- Contents Contents ogy, biochemical/chemical engineering and applied Introduction.- The Hydrologic Status of the Ever- 1. Introduction; 2. Stepping back from "the lad- microbiology, university institutes, research groups glades, Past and Present Alteration Effects.- Soils of der": reflections on a model of participatory work in industry the Everglades Landscape.- Vegetation of the Ever- with children; 3. Differentiating and evaluating con- glades.- Ecological Status of the Everglades: Histor- ceptions and examples of participation in environ- Type of publication ical and Current Comparisons of Ecosystem Struc- ment-related learning; 4. Learning in and as partici- Reviews ture and Function.- Long-term Water Chemistry pation: a case study from health promoting schools; Along Nutrient and Hydrologic Gradients.- Hydrol- 5. Environmental learning and categories of interest: ogy Gradients in the Everglades.- Soil Chemistry and exploring modes of participation in a conservation Due December 2007 P Storage Along Nutrient Gradients.- Patterns of NGO; 6. Participation and the ecology of environ- Algal Assemblages Along a Phosphorus Gradient.- mental awareness and action; 7. Participation, situat- 2008. Approx.520 p. Also available online. (Advances in Biochem- Macrophyte Community Responses to Long-term ed culture and practical reason and situated culture; ical Engineering / Biotechnology, Vol. 109) Hardcover Nutrient Additions, Altered Hydroperiod and Fire.- 8. From practice to theory: [..] 389,00 € [..] Fields of interest ISBN 978-3-540-75200-4 Fields of interest Environment, general; Environmental Management; Ecology; Environmental Management; Waste Water Education & Society; Curriculum Studies; Geoecolo- Technology / Water Pollution Control / Water Man- gy/Natural Processes agement / Aquatic Pollution; Nature Conservation; Target groups Limnology Professionals, researchers and students in environ- Target groups mental, health and sustainable development educa- Researchers, land managers, peatland ecologists, tion restoration ecologists and watershed scientists. Type of publication Type of publication Contributed volume Monograph

Due October 2007 Due May 2008

2007. xxii, 346p. Hardcover 2008. Approx. 727 pp. 328 illus. (Ecological Studies, Vol. 201) 129,95 € Hardcover ISBN 978-1-4020-6415-9 117,05 € ISBN 978-0-387-98796-5 springer.com/booksellers Life Science 109

R.P. Roetter, Wageningen University, The Netherlands; H.v. G. Romano, Jefferson Medical College, Philadelphia, PA, USA (Ed.) A.G. Rossi, University of Edinburgh, UK; D.A. Sawatzky, University Keulen, Wageningen University, The Netherlands; M. Kuiper, Wa- of Edinburgh, UK (Eds.) geningen University, The Netherlands; J. Verhagen, Wageningen University, The Netherlands; H.H.v. Laar, Wageningen University, New Stem Cell Techniques The Netherlands (Eds.) The Resolution of Inflammation

Science for Agriculture and Rural Development in Low-income Fields of interest Much progress has been made in elucidating the Cell Biology mechanisms regulating the induction and progres- Countries sion of inflammatory diseases. More recently, how- Type of publication ever, it has become apparent that the manipulation Contributed volume of mechanisms governing the resolution of inflammation is an important way to develop novel strate- Features Due August 2008 gies for the therapy of such diseases. This book pro- Illustrates implementation of novel research ap- vides an up-to-date and comprehensive view on the resolution of inflammation and on new develop- proaches to Rural Development and Sustainable 2008. Approx. 350 p. (Methods in Molecular Biology, Preliminary Agriculture in low-income countries Draws lessons entry 2108) Hardcover ments in this area (e.g. pro-resolution mediators, from pluri-annual collaborative research projects apoptosis, macrophage clearance of apoptotic cells, on RDSA from sub-Saharan Africa and E, S and SE 99,95 € possible novel drug developments). The chapters are Asia Identifies gaps in knowledge and outlines fu- ISBN 978-1-58829-617-7 written by leading scientists in the field. This top- ture challenges and promising directions of RDSA ical volume is of interest to medical and scientific research Provides examples of contributions of re- researchers in academia and industry working on search to increased [..] inflammatory and cardiovascular diseases such as arthritis, asthma, bronchitis, atherosclerosis, and Contents more. Preface, Executive Summary, List of Abbreviations. 1. Agriculture in a dynamic world, R.P. Roetter, H. Features Van Keulen, J. Verhagen and M. Kuiper. 2. Histor- Written by leading scientists in the field Proposes ical context of agricultural development, H. Van novel strategies for the therapy of inflammatory dis- Keulen. 3. Food security, R.P. Roetter and H. Van eases Keulen. 4. Agriculture and environment, J. Verha- Contents gen, H. Wösten and A. De Jager. 5. Rural livelihoods: The resolution of acute inflammation: a ‘tipping Interplay between farm activities, non-farm activi- point’ in the development of chronic inflammatory ties and the resource base, M. Kuiper, G. Meijerink diseases.- Granulocyte apoptosis.- Cell sur- and D. Eaton. 6. Lessons learned, R.P. Roetter, M. face molecular changes associated with apoptosis.- Kuiper, H. Van Keulen, J. Verhagen and G. Mei- Fate of macrophages once having ingested apoptotic jerink. 7. Project assessments, A. De [..] cells: lymphatic clearance or in situ apoptosis?.- Nov- Fields of interest el lipid mediators in resolution and their aspirin trig- Agriculture; Environment, general; Development gered epimers: lipoxins, resolvins, and protectins.- Economics; Ecology; Applied Geosciences Beyond inflammation: Lipoxins; resolution of inflammation and regulation of fibrosis.- Anti-inflam- Target groups matory glucocorticoids and Annexin 1.- The resolu- Scientists and decision makers with a stake in ru- tion of airway inflammation in [..] ral development and sustainable agriculture in sub- saharan Africa, Asia (and Latin America), includ- Fields of interest ing fellow scientists, research managers, potential Immunology; Cell Biology; Biochemistry, general; investors (donors R & D), planners and poli- Biomedicine general; Pharmacology/Toxicology cy makers from "the North and the South" (national Target groups and international research centers dealing with agri- Scientific libraries; scientists and clinicians from Im- culture, environment and rural development). munology, Inflammation Research, Biomedicine; Type of publication pharmaceutical industry Contributed volume Type of publication Monograph Due November 2007 Due December 2007 2008. Approx. 240 p. Hardcover

120,00 € 2008. Approx. 230 p. (Progress in Inflammation Research) Hard- ISBN 978-1-4020-6616-0 cover 119,00 € ISBN 978-3-7643-7505-8 110 Life Science springer.com/booksellers

J.A. Rothnagel, Institute for Molecular Bioscience (Ed.) K.L. Rudolph, Medical School Hannover, Germany (Ed.) J. Rushen, Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, Agassiz; A.M.d. Passillé, Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, Agassiz; Fluorescent Proteins Telomeres and Telomerase in M.A.G.v. Keyserlingk, Animal Welfare Program, University of British Columbia, Vancouver; D.M. Weary, Animal Welfare Pro- Aging, Disease, and Cancer gram, University of British Columbia, Vancouver Molecular Mechanisms of Adult Stem Cell Ageing Fields of interest The Welfare of Cattle Cell Biology The understanding of the molecular mechanisms un- Type of publication derlying the ageing process is essential to improve Contributed volume This book, written by the leading international re- quality of life and ‘health span’ in the growing pop- search scientists in the field, is the first to cover all ulations of the elderly. Telomere shortening repre- aspects of research into the welfare of dairy, veal Due January 2009 sents one of the basic aspects of ageing and telomere and beef cattle. The book provides a thorough and dysfunction could contribute to the accumulation of critical review of the most up-to-date research on 2008. 300 p. (Methods in Molecular Biology, Preliminary entry DNA damage during ageing. This book summarizes the welfare of cattle, covering behaviour, nutrition 2033) Hardcover experimental evidence and clinical data indicating and feeding, housing and management, stockman- that telomere dysfunction influences human ageing, ship, and stress physiology, as well as transport and 74,95 € diseases and cancer. In addition, the book describes slaughter. It provides a detailed and critical analysis ISBN 978-1-58829-885-0 our current knowledge on checkpoints that limit cel- of the main indicators of animal welfare and covers lular lifespan (senescence) and survival (apoptosis, the main threats to animal welfare in modern cat- crisis) in response to telomere dysfunction. A spe- tle production systems. Although the focus is large- cial focus of the book is on adult stem cells. There ly on cattle in developed countries, this book should is emerging evidence that adult stem cell ageing im- also be of relevance in developing countries, where pairs organismal fitness and survival and contributes issues affecting the welfare of domestic animals are to cancer formation (cancer stem cells). The book beginning to be addressed. The book is intended for summarizes basic mechanisms of adult stem cell age- researchers and research students in veterinary and ing. Moreover, the authors describe evidence that animal science and animal welfare science, as well as telomere dysfunction impairs stem cell [..] professionals in the beef and dairy industries.

Features Features Provides an in depth review of our current knowl- Covers all aspects of animal welfare in beef, veal and edge on the role of telomeres and telomerase in age- dairy cattle production systems Extensive and critical ing, disease and cancer Special focus is on adult stem review of up-to-date research results Critical analysis cells Describes future directions in research on adult of indicators of animal welfare stem cell ageing, telomeres, and cancer Excellent basis for academic teachers, scientists, and students in- Contents terested in the areas of stem cell ageing, telomeres Chapter 1. Introduction: what is animal welfare? Part and telomerase, regeneration, and [..] 1: Indicators of animal welfare Chapter 2. Health, disease and productivity Chapter 3. Stress and phys- Fields of interest iological indicators of animal welfare Chapter 4. An- Human Genetics; Biochemistry, general; Cell Biolo- imal behaviour Part 2: Challenges to animal welfare gy; Cancer Research Chapter 5. Acute or short term challenges to animal welfare Chapter 6. Housing for adult cattle Chap- Target groups ter 7. Housing for growing animals Chapter 8. Feed- Libraries, institutes, researchers, scientists, physi- ing and nutrition Chapter 9. Stockmanship and the cians, graduates interactions between people and cattle Chapter 10. Type of publication Conclusions Monograph Fields of interest Zoology; Behavioural Sciences; Veterinary Medicine; Due November 2007 Animal Genetics and Genomics; Animal Physiology

2008. XIV, 311 p. 39 illus., 25 in color Hardcover Target groups Research workers, students and university 149,95 € teachers in farm animal welfare, dairy and animal ISBN 978-3-540-73708-7 science, veterinary science, professionals, specialists and extension workers in dairy, beef and veal production, bovine veterinarians, animal welfare specialists

Type of publication Monograph

Due October 2007

2007. Approx. 310 p. (Animal Welfare, Vol. 5) Hardcover

114,95 € ISBN 978-1-4020-6557-6 springer.com/booksellers Life Science 111

G. Rédei, University of Missouri, Columbia, MO, USA (Ed.) G. Rédei, University of Missouri, Columbia, MO, USA (Ed.) D. Röser, Finnish Forest Research Institute, Joensuu, Finland; A. Asikainen, Finnish Forest Research Institute, Joensuu, Finland; K. Raulund-Rasmussen, The Royal Veterinary and Agricultural Encyclopedia of Genetics, Encyclopedia of Genetics, University, Hoersholm, Denmark; I. Stupak, The Royal Veterinary Genomics, Proteomics, and Genomics, Proteomics, and and Agricultural University, Hoersholm, Denmark (Eds.) Informatics Informatics Sustainable Use of Forest Biomass for Energy

The new, 3rd edition is an updated version of the The new, 3rd edition is an updated version of the A Synthesis with Focus on the Baltic and Nordic Region best-seller earlier books. It includes about 56% more best-seller earlier books. It includes about 56% more words than the 1,392-page 2nd edition of 2003. The words than the 1,392-page 2nd edition of 2003. The number of illustrations increased to almost 2,000 and number of illustrations increased to almost 2,000 and The large-scale utilization of forest biomass for ener- their quality has improved by design and four col- their quality has improved by design and four col- gy is still in its infancy and there is a need for knowl- ors. Cross-references among entries are expanded. ors. Cross-references among entries are expanded. edge about the short- and long-term consequences The statements are supported by references; more The statements are supported by references; more of intensive forest biomass harvesting on the forest than 14,000 journal papers and more than 3,000 than 14,000 journal papers and more than 3,000 ecosystem and the economic consequences for the books are listed. The book includes ~1,800 current books are listed. The book includes ~1,800 current forest owner. Sustainable Use of Forest Biomass for databases and web servers. Retractions and corrigen- databases and web servers. Retractions and corrigen- Energy makes use of the vast amount of knowledge da are pointed out. It covers the basics and the lat- da are pointed out. It covers the basics and the lat- within the Nordic-Baltic region to bridge the gap be- est in genomics, proteomics, genetic engineering, est in genomics, proteomics, genetic engineering, tween the uncertainty of scientific knowledge and small RNAs, transcription factories, chromosome small RNAs, transcription factories, chromosome general principles on the one hand, and more con- territories, stem cells, genetic networks, epigenetics, territories, stem cells, genetic networks, epigenetics, crete practical forest management and policy mak- prions, hereditary diseases, patents, etc. Similar inte- prions, hereditary diseases, patents, etc. Similar inte- ing in the forestry and energy sectors on the other. grated information is not available in textbooks or grated information is not available in textbooks or The focus on the Nordic and Baltic countries makes on the Internet. The journal reviews called it the best, on the Internet. The journal reviews called it the best, it possible to compare two groups of countries in Eu- high-quality resource for researchers, instructors and high-quality resource for researchers, instructors and rope with substantial differences in legislative and students of basic and applied biology, as well as for students of basic and applied biology, as well as for economic frameworks. Nordic and Baltic scientists physicians and lawyers or [..] physicians and lawyers or [..] from ecological, economic, social, and technological Fields of interest Fields of interest disciplines joined forces to synthesize current knowl- Human Genetics; Cell Biology; Microbial Genet- Human Genetics; Cell Biology; Microbial Genet- edge, generate new results, describe cases, and create ics and Genomics; Animal Genetics and Genomics; ics and Genomics; Animal Genetics and Genomics; a basis for the development of [..] Bioinformatics; Proteomics Bioinformatics; Proteomics Features Target groups Target groups Practical, sustainable management of forest biomass Research workers in general genetics, genomics, pro- Research workers in general genetics, genomics, pro- for energy, development of national, regional man- teomics, biochemistry, molecular biology, cell biolo- teomics, biochemistry, molecular biology, cell biolo- agement, policy recommendations Region knowl- gy, evolution, cytogenetics, human genetics, ethics, gy, evolution, cytogenetics, human genetics, ethics, edge allows for movement from general principles natural philosophy; professors, teachers, librarians natural philosophy, professors, teachers, librarians towards management recommendations Focus on at universities, colleges and progressive secondary at universities, colleges and progressive secondary Nordic, Baltic countries to compare 2 groups schools; physicians, law professionals; students at all schools, physicians, law professionals, students at all of European countries with different backgrounds levels of basic and applied biology; science adminis- levels of basic and applied biology, science adminis- Only provider of background knowledge for decision trators and journal editors, public libraries trators and journal editors, public libraries support tool, EnerTree [..]

Type of publication Type of publication Contents Encyclop(a)edia Encyclop(a)edia 1. Wood energy in the European energy and forestry context; A. Lunnan, I. Stupak-Møller.- 2. Wood energy resources and utilisation in Nordic and Baltic Due April 2008 Due March 2008 countries; A. Asikainen, D. Röser.- 3. Effects of in- tensified forest biomass utilisation on short and Originally published by Wiley-Liss, John Wiley & Sons, Inc., 2003 Originally published by Wiley-Liss, John Wiley & Sons, Inc., 2003 long term site fertility; K. Raulund Rasmussen.- 4. Use of wood ash for compensation of nutrient ex- 2008. eReference. 2008. Approx. 2400 p. 1900 illus., 2 volumes Hardcover port; E. Karltun.- 5. Insect pests and biodiversity; M. Schroeder, M. Jonsell.- 6. Economic implications of 799,00 € 799,00 € forest energy utilisation; A. Lunnan.- 7. Management ISBN 978-1-4020-6754-9 ISBN 978-1-4020-6753-2 recommendations; A. Asikainen et al.- 8. Policy recommendations; A. Lunnan.- 9. [..]

Fields of interest Forestry; Forestry Management; Ecosystems; Biodi- versity; Applied Ecology; Agricultural Economics

Target groups Forest scientists, forestry students, forest extension, forest resource managers, forest and energy policy makers, energy sector

Type of publication Graduate/advanced undergraduate textbook

Due October 2007

2007. Approx. 250 p. (Managing Forest Ecosystems, Vol. 12) Hardcover 112 Life Science springer.com/booksellers

100,00 € H. Sakio, T. Tamura (Eds.) R.J. Salvi, University of Buffalo, NY, USA; A.N. Popper, University ISBN 978-1-4020-5053-4 of Maryland, College Park, MD, USA; R.R. Fay, Loyola University of Chicago, IL, USA (Eds.) Ecology of Riparian Forests in Japan

Disturbance, Life-history and Regeneration Hair Cell Regeneration, Repair, and Protection

Fields of interest Forestry Management; Forestry; Plant Ecology; Ecol- The sensory hair cells in the inner ear and vestibular ogy system convert mechanical stimuli, sound and motion into neural activity that is responsible for the Type of publication sensations of hearing, motion and head position. In Monograph mammals, the loss of hair cells from acoustic over- stimulation, ototoxic drugs and aging is irreversible, Due July 2008 leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or 2008. Approx. 280 p. Hardcover complete function. Moreover, partially damaged hair cells can undergo self-repair or be protected from ISBN 978-4-431-76736-7 traumatic insults by external compounds. This volume provides a comprehensive survey of what is currently known about the regeneration, repair and protection of sensory hair cells and subsequent recovery of function in the auditory and vestibular system. The aim is to provide graduate students, postdoctoral fellows, clinicians and scientists in related disciplines with the biological bases of hair cells and with an understanding of the [..]

Features Presents the latest discoveries of hair cell regeneration and the recognition that stem cells exist in many regions of the nervous system, including the inner ear Discusses the potential for helping people with hearing loss

Contents Overview: Regeneration and Repair. - Morphologi- cal Correlates of Regeneration and Repair in the In- ner Ear.- The Recovery of Function in the Avian Au- ditory System Following Ototrauma.- Functional Re- covery Following Hair Cell Regeneration in Birds.- Hair Cell Regeneration: Mechanisms Guiding Cel- lular Proliferation and Differentiation.- Protection and Repair of Inner Ear Sensory Cells.- Gene Arrays, Cell Lines, Stem Cells, and Sensory Regeneration in Mammalian Ears.

Fields of interest Neurobiology; Human Physiology; Neurosciences

Target groups Researchers, graduate students

Type of publication Contributed volume

Due March 2008

2008. Approx. 300 p. (Springer Handbook of Auditory Research, Vol. 33) Hardcover

99,35 € ISBN 978-0-387-73363-0 springer.com/booksellers Life Science 113

B.J. Saville, Trent University, Peterborough, ON, Canada (Ed.) U.B. Schambra, East Tennessee State University, Johnson City, U. Schiewer, University of Rostock, Germany (Ed.) USA Fungal Genomics Ecology of Baltic Coastal Waters Prenatal Mouse Brain Atlas

This volume provides the first comprehensive Fields of interest Prenatal Mouse Brain Atlas is the only book available overview of the enormous ecological diversity of Microbial Genetics and Genomics; Cell Biology for studies of the mouse brain before birth. A previ- Baltic coastal ecosystems. A short introduction into ous edition, Atlas of the Prenatal Mouse Brain, was the Baltic Sea as a reference ecosystem is followed by Type of publication used by researchers working on normal brain devel- detailed descriptions of the characteristics of coastal Contributed volume opment and abnormal development (toxicological ecosystems. Ecological case studies from the follow- and teratological studies), which has recently gained ing four regions illustrate the different reactions of Due March 2009 particular importance in genetic studies. Since the these ecosystems to natural and anthropogenic in- completion of the Human Genome Project, identi- fluences: Southern Baltic coast: Fjörden, Boddens, fication of human genes has allowed researchers to 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Lagoons and nearshore zones, Eastern Baltic coast: entry 2231) Hardcover produce transgenic mice to study individual genes Gulf of Gdansk, Gulf of Riga, Northeastern Baltic in the brain. The mouse is ideal for these genetic coast: Neva Estuary and Gulf of Finland, Western 76,65 € projects, but since mice are notorious for killing de- Baltic coast: Stockholm Archipelago, Askö area and ISBN 978-1-60327-276-6 fective off-spring, the studies on the effects of gene Himmerfjärden, Odense Fjord and Kerteminde manipulations often have to be performed on pre- Fjord/Kertinge Nor. This volume also presents a syn- natal mouse brains. This new greatly expanded edi- thesis of the common and distinguishing character- tion provides an easily accessible tool for researchers istics and processes of the coastal waters compared in the fields of normal and abnormal brain devel- with the Baltic Proper, as well as highlighting re- opment for their genetic, toxicological, teratologi- search deficits. An outlook on further developments cal and developmental studies. Users will be able to in coastal research rounds off the volume. compare structure shown in the Atlas to [..] Features Features For the first time data on Baltic coastal ecosystems Complete mapping of the developing mouse brain, are presented to a broad scientific audience and in a featuring imaging of whole brain sections Includes clear and comprehensive way DVD with color images Contents Contents The Baltic Sea.- The Baltic Coastal Zones.- Darß- Preface.- Introduction.- Methods.- References.- List Zingst-, Northern Rügener Boddens and Schlei.- of Structures.- List of Abbreviations.- Gestational Greifswalder Bodden, Wismar-Bucht and Salzhaff.- Day 12.- Gestational Day 14.- Gestational Day 16.- The Szczecin (Oder-) Lagoon.- Near-Shore Zones Gestational Day 18. Koserow and Tromper Wiek.- Gulf of Gdansk and Puck Bay.- The Vistula Lagoon.- Curonian Lagoon.- Fields of interest Gulf of Riga and Pärnu Bay.- Haapsalu and Mat- Neurosciences; Developmental Biology; Human Ge- salu Bays.- Neva Estuary Ecosystem.- The Gulf of netics; Anatomy; Human Physiology Finland.- Stockholm Archipelago.- Askö Area and Himmerfjärden.- Odense Fjord and Kerteminde Target groups Fjord/Kertinge Nor.- Synthesis. Researchers and advanced students in university working in Neuroscience, Physiology, Anatomy/His- Fields of interest tology, and Developmental Biology Marine Ecology; Ecosystems; Waste Water Tech- nology / Water Pollution Control / Water Manage- Type of publication ment / Aquatic Pollution; Nature Conservation; Atlas Geoecology/Natural Processes; Biodiversity

Due January 2008 Target groups Researchers, environmental managers, advanced stu- Originally published by Academic Press, 1992 dents Type of publication 2007. Approx. 410 p. With DVD. Spiral binding Contributed volume 150,15 € ISBN 978-0-387-47089-4 Due December 2007

2008. Approx. 450 p. 108 illus. (Ecological Studies, Vol. 197) Hard- cover

159,95 € ISBN 978-3-540-73523-6 114 Life Science springer.com/booksellers

M. Schmidt, University of Cottbus; J. Glasson, Oxford Brookes P. Schmitt-Kopplin, GSF-National Research Center for Environ- D. Schomburg, Universität zu Köln, Germany; I. Schomburg, University, Oxford, UK; L. Emmelin, Karlskrona, Sweden; H. Hel- ment and Health Institute for Ecological Chemistry, Neuherberg, Universität zu Köln, Germany (Eds.) bron, University of Cottbus (Eds.) Germany (Ed.) Class 2 Transferases XII Standards and Thresholds for Capillary Electrophoresis EC 2.7.8 - 2.9.1 Impact Assessment Methods and Protocols

The objective of the "Springer Handbook of En- Standards and Thresholds play an important role in Capillary Electrophoresis: Methods and Protocols zymes" is to provide in concise form data on en- many stages of the Environmental Impact Assess- presents a selection of current capillary electrophore- zymes sufficiently well characterized. Data sheets ment (EIA) process. They can be legally-binding or sis methods used to separate representative types of are arranged in their EC-Number sequence. The guidance values and are linked to environmental da- molecules and particles and in combination with dif- volumes are arranged according to enzyme classes. ta. This publication provides a comprehensive col- ferent detection techniques. The volume is intended Considerable progress has been made in enzymology lection of standards and thresholds, their deriva- for beginners in the field and provides an overview since the publication of the first edition (published tion and application in case studies of EIA projects. of the technique and a starting point for the explo- as "Enzyme Handbook"): many enzymes are new- The first part introduces the nature of standards and ration of the defined literature on different applica- ly classified or reclassified. In the 2nd edition each thresholds and key drivers for their determination. tion topics. As a beginning text, each technique is ex- entry is correlated with references and one or more The book then describes, in Part II, technical stan- plained in simple terms, assuming only minimal pre- source organisms. New datafields are created: "appli- dards from the perspective of EIA projects. Part III vious knowledge of the methods. A Notes section ac- cation" and "engineering" (for the properties of en- addresses the issue from the other side, environment companies each chapter and addresses problems that zymes where the sequence has been changed). Alto- and human health, and discusses the assessment of may occur and how to overcome them. In Part I, An- gether the amount of data has doubled so that the impacts on the sensitivity or value of environmen- alyte-Oriented, contributors present methods and 2nd edition will consist of 39 volumes plus synonym tal and health components. Part IV sets out some protocols based on sample type and size for inorgan- index. This collection is an indispensable source of emerging issues for standard and threshold with ref- ic and organic small ions, anionic, cationic, and neu- information for researchers in biochemistry, biotech- erence to new sectors and with recent instruments. tral pollutants and pharmaceuticals, sugars, amino nology, organic and analytical chemistry, and food The book concludes in Part V with the role of moni- acids, nucleotides and DNA, and synthetic copoly- sciences. toring, and final implementation. mers up to microorganisms. In Part II, Method-Ori- ented, authors present the more [..] Features Features Concise and complete description of about 4,400 en- Examples for the derivation of values and applica- Features zymes sufficiently well characterized for application tions in case studies Discussion of effectiveness and All techniques are described in detail from beginning in analytical, synthetic and biotechnology processes efficiency of standards and thresholds as instruments to end Includes important, practical details which are as well as in food industry Second edition is totally of environmental management hard to find elsewhere Techniques are written with new Content has doubled Academic researchers will the beginner in mind using simple, easy-to-under- prefer the print version Fields of interest stand terms Environmental Law; Environmental Management; Fields of interest Administrative Law Contents Biochemistry, general; Cancer Research; Pharmacol- Determination of Small Ions with Capillary Elec- ogy/Toxicology; Biotechnology; Veterinary Medicine Target groups trophoresis and Contactless Conductivity Detec- Government and local authorities; libraries tion.- Metal Analysis with Capillary Zone Elec- Target groups trophoresis.- Measurement of Low Molecular Industrial and academic research Type of publication Weight Carboxylic Acids in Ambient Air and Vehi- Reference work cle Emission by Capillary Electrophoresis.- Determi- Type of publication nation of Aliphatic Low Molecular Weight and Bio- Reference work Due December 2007 genic Amines by Capillary Zone Electrophoresis.- Capillary Electrophoretic Analysis of Organic Pollu- Due November 2007 2008. Approx. 400 p. (Environmental Protection in the European tants.- Capillary Electrophoresis with Laser-Induced Union, Vol. 3) Hardcover Fluorescence: Environmental Applications.- Practical Originally published as volume 13 in the series: Enzyme Hand- Considerations for the Analysis of Ionic and Neutral book 79,95 € [..] ISBN 978-3-540-31140-9 Fields of interest 2008. 572 (Springer Handbook of Enzymes, Vol. 39) Hardcover Cell Biology; Human Genetics 279,00 € Target groups ISBN 978-3-540-71523-8 Molecular and cell biologists, geneticists, biologists

Type of publication Contributed volume

Due November 2007

2007. Apporx. 772 p. 228 illus. (Methods in Molecular Biology, Vol. 384) Hardcover

114,95 € ISBN 978-1-58829-539-2 springer.com/booksellers Life Science 115

C. Schönbach, School of Biological Sciences, Nanyang Techno- C.B. Scott, University of Southern Maine, Gorham, ME, USA S. Seino, Kobe University, Japan; G. Bell, Chicago University, USA logical University, Nanyang, Singapore; S. Ranganathan, Depart- (Eds.) ment of Chemistry and Biomolecular Sciences & Biotechnolo- gy Research Institute, Macquarie University, Australia; V. Brusic, A Primer for the the Sports Director of Bioinformatics, Cancer Vaccine Center, Dana-Farber Pancreatic Beta Cell in Health and Cancer Institute, USA (Eds.) Nutritionist and Exercise Physiologist Disease

Immunoinformatics Thermodynamics, Bioenergetics, and Metabolism The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and se- This is the first volume in a series that will be ded- This book discusses nutrition and relies on biochem- crete insulin. This metabolic hormone plays a central icated to publishing advances in immunomics par- ical descriptions of metabolism in that the methods role in the maintenance of glucose homeostasis, reg- ticularly those focusing on systemic and integrative of estimating energy expenditure that are present- ulating glucose uptake in muscle and adipose tissue approaches in basic and clinical immunology, im- ed center around thermodynamic principles of car- as well as carbohydrate, fat, and protein metabolism munoinformatics, and immunologically relevant in- bohydrate and fat oxidation in open as opposed to in these tissues and the liver. This book provides a strumentation and high-throughput screening meth- closed systems. comprehensive up-to-date review of the beta cell in ods. Immunoinformatics utilizes mathematics, in- health and disease. Chapters address the architec- formation science, computer engineering, genomics, Fields of interest ture and pathology of normal and diabetic pancre- proteomics and immunological methods to bridge Nutrition; Animal Physiology; Biochemistry, general; atic islets; regulation of beta-cell proliferation and immunology and informatics. Ten expert reviews Sports Medicine death; the potential of stem cells and extra-pancreat- introduce bioinformaticians and immunologists ic tissues as beta-cell replacement therapies; insulin alike to successfully applied data-driven strategies Target groups biosynthesis; regulation of insulin secretion includ- in MHC, TCR, peptide-MHC and allergen research, Sports nutritionists, biochemists, physiologists, and ing metabolic control, ion channels, gap junctions, epitope prediction, de-immunization of therapeu- sports medicine specialists cyclic AMP, incretins, and exocytosis; development tic proteins, host-pathogen interactions, modeling of novel imaging techniques; and genetic disorders of of immune responses to pathogens and large-scale Type of publication the beta cell. A primary aim of the book is to encour- chemical mutagenesis-driven genetic analyses sys- Monograph age students and young basic and clinical investiga- tems. In contrast to existing books on immunoinfor- tors to become [..] matics which emphasize epitope prediction this vol- Due December 2008 ume presents a cross-section of immunoinformatic Fields of interest Cell Biology; Diabetes; Molecular Medicine; Internal research. The contributions show [..] 2009. Approx. 220 p. Hardcover Medicine Features 76,65 € Highlights the systemic and integrative approaches ISBN 978-1-60327-382-4 Type of publication in immunoinformatics Monograph

Contents Due December 2007 IMGT-ONTOLOGY, IMGT® Databases, Tools and Web Resources for Immunoinformatics .- IMGT standardization for molecular characterization of 2008. Hardcover the T cell receptor/peptide/MHC complexes.- Struc- ISBN 978-4-431-75451-0 tural Immunoinformatics .- In Silico QSAR-Based Predictions of Class I and Class II MHC Epitopes .- Immunoinformatics Applied to Modifying and Im- proving Biological Therapeutics .- Plasticity of Den- dritic Cell Transcriptional Responses to Antigen: Functional States of Dendritic Cells .- Understand- ing the Immune System by Computer-aided Mod- elling .- Simulation of HIV-1 Molecular Evolution in Response to [..]

Fields of interest Bioinformatics; Immunology; Microbiology; Human Genetics

Target groups Scientists, researchers, students and professionals in the fields of Immunology, Bioinformatics, Micro- biology, Genetics, Systems Biology, Biotechnology, Computational Biology

Type of publication Contributed volume

Due December 2007

2008. Approx. 190 p. (Immunomics Reviews:, Vol. 1) Hardcover

109,95 € ISBN 978-0-387-72967-1 116 Life Science springer.com/booksellers

P.M. Selzer, Akzo Nobel Intervet Innovation GmbH, Schwaben- J.K. Setlow (Ed.) Z. Shareefdeen, BIOREM Technologies Inc., Guelph, ON, Canada; heim; R. Marhöfer, Akzo Nobel Intervet Innovation GmbH, A. Singh, Petrozyme Technologies Inc., Guelph, ON, Canada (Eds.) Schwabenheim; A. Rohwer, Akzo Nobel Intervet Innovation GmbH, Schwabenheim Genetic Engineering Biotechnology for Odor and Air Applied Bioinformatics Pollution Control Genetic Engineering: Principles and Methods, pub- An Introduction lished by Springer since 1979, presents state-of-the- art discussions in modern genetics and genetic en- Biotechnology offers one of the most economical gineering. This focus affirms a commitment to pub- and environmentally benign methods of air pollu- Confused by cryptic computer programs, algorithms lish important reviews of the broadest interest to tion control for industrial and municipal airstreams. and formulae? In this book, anyone who can operate geneticists and their colleagues in affiliated disci- Volatile organic and inorganic odorous compounds a PC, standard software and the Internet will learn to plines. Recent volumes have covered gene therapy from various industries are emitted in large quanti- understand the biological basis of bioinformatics of research, genetic mapping, plant science and tech- ties and create hazards to the ecosystem and health the existence as well as the source and availability of nology, transport protein biochemistry, and viral effects to humans. Thus, the demand for odor and bioinformatics software how to apply these tools and vectors in gene therapy, among other topics. air pollution control systems that provide nui- interpret results with confidence. This is aided by in- sance-free, breathable air is constantly growing. An Features troductory chapters to important aspects of bioinfor- international board of authors from universities, Genetic Engineering: Principles and Methods is es- matics detailed bioinformatics exercises, including research institutes, and industries describe various sential reading for all genetic engineers and molecu- solutions a glossary of definitions and terminology biotechnological methods ranging from laboratory, lar biologists & geneticists, including academics, relating to bioinformatics. Quickly learn to manage to pilot evaluation and to full-scale process imple- bench scientists, and industry professionals wishing bioinformatics! mentation. Topics include bioprocesses for the treat- to take advantage of the latest and greatest in this ment of odors and air pollutants in wastewater treat- continuously emerging field. Features ment plants, rendering plants, chemical production Easily understandable introduction in an overview facilities, and food and flavor manufacturing facili- style Practical examples with exercises and solutions Contents Identification & analysis of microRNA's.- Gene ties. In addition to the basic microbiological and engineering aspects, the design, modeling and control Contents cloning and expression.- Biofilms assayed by confo- of bioreactors are also presented. Computers, operating systems and the Internet.- cal laser scanning microscopy.- Genetic mapping.- Cell penetrating peptide.- Protein sequence database The biological foundations of bioinformatics.- Bi- Features methods.- Assisted folding & assembly of pro- ological databases.- Sequence comparisons and se- First book on biotechnological processes for odor teins.- Topological patterns in protein networks.- quence-based database searches.- The decoding of and air pollution control, the nuisance and hazard Tetracyclines and gene regulations.- Analysis of mi- eukaryotic genomes.- Protein structures and struc- side effects of industries Combines basic microbi- crobial genome sequences.- Defense signaling ture-based rational drug design.-Systems biology – ological and engineering aspects with the design, the functional analysis of genomes.- Comparative modeling and control of bioreactors genome analyses.- Solutions to the Exercises.- Glos- Fields of interest Human Genetics; Biochemistry, general; Plant Sci- sary Fields of interest ences Biotechnology; Biochemical Engineering; Atmo- Fields of interest spheric Protection/Air Quality Control/Air Pollu- Bioinformatics; Computer Appl. in Life Sciences Target groups genetic engineers, molecular biologists & ge- tion; Applied Microbiology; Microbiology; Industrial and Production Engineering Target groups neticists, academics, bench scientists, industry professionals Advanced Students of bioinformatics (principal or Target groups subsidiary subject within life sciences or informatics) Type of publication Researchers at universities, national and industrial R and D laboratories, chemical, environmental and Type of publication Contributed volume civil engineers, industrial consultants Graduate/advanced undergraduate textbook Due January 2008 Type of publication Due January 2008 Monograph 2007. Approx. 320 p. (Genetic Engineering: Principles and Meth- Book is based on a German language edition (2003) ods, Vol. 29) Hardcover Due October 2007 ISBN 978-0-387-33999-3 2008. Approx. 350 p. 69 color illus. Softcover 2008. XVIII, 409 p. 70 illus. Softcover

26,95 € 64,95 € ISBN 978-3-540-72799-6 ISBN 978-3-540-74049-0 springer.com/booksellers Life Science 117

P.T. Sharpe, Dental Institute, London, UK; I. Mason, King’s College London, London, UK (Eds.)

Molecular Embryology

Methods and Protocols

This new edition offers a comprehensive guide to cutting-edge methods used today across the field of molecular embryology. These powerful techniques take advantage of the most commonly used vertebrate experimental models: murine embryos for their genetics, chick embryos for in vivo manipulation, zebrafish for mutagenesis, amphibian embryos, and nonvertebrate chordates. The book emphasizes the most important methods of experimental molecular biology and the particular advantages of each different species.

Contents Basic Principles of Fluorescence and Energy Trans- fer.- Multiplex Detection of Mutations.- Detection of Salmonella species in foodstuffs.- Identification of homozygous transgenic mice by genomic real time PCR.- Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCyclerÒ instrument and a SYBR GreenI based assay: determining FAT10 mRNA levels in hepato- cellular carcinoma.- Absolute quantitation of Feline Leukemia Virus (FeLV) proviral DNA and viral RNA loads by TaqMan® Real-time PCR and RT-PCR.- High throughput real-time PCR.- Design and Use of [..]

Fields of interest Developmental Biology

Type of publication Contributed volume

Due August 2008

2008. Approx. 493 p. (Methods in Molecular Biology, Preliminary entry 2096) Hardcover

109,95 € ISBN 978-1-58829-431-9 springer.com/booksellers Life Science 118

S. Shen, Nankai University, Tianjin, China; J.A. Tuszynski, Universi- R.W. Shonkwiler, Georgia Institute of Technology, Atlanta, Geor- S.L. Shorte, Institut Pasteur, Paris, France; F. Frischknecht, Univer- ty of Alberta, Edmonton, AB, Canada gia, USA sity of Heidelberg, Gemany (Eds.)

Theory and Mathematical Methods Mathematical Biology Imaging Cellular and Molecular in Bioinformatics An Introduction with Maple and Matlab Biological Functions

This monograph addresses, in a systematic and ped- A greatly expanded and updated edition of the pop- “Imaging Cellular and Molecular Biological Func- agogical manner, the mathematical methods and ular Introduction to the Mathematics of Biology tion” provides a unique selection of essays by lead- the algorithms required to deal with the molecular- (Yeargers, Shonkwiler and Herod, Birkhäuser 1996), ing experts, aiming at scientist and student alike who ly based problems of bioinformatics. The book will this textbook aims to present mathematical biology are interested in all aspects of modern imaging, from be useful to students, research scientists and practi- as not merely the intrusion of one science into an- its application and up-scaling to its development. tioners of bioinformatics and related fields, especial- other, but rather as a field with a unity of its own. It The chapter content ranges from the basic through ly those who are interested in the underlying math- retains and expands on the concept of the "comput- to complex overview of method and protocols, and ematical methods and theory. Among the methods er biology laboratory,” giving students a general per- there is also practical and detailed “how-to” con- presented in the book, prominent attention is giv- spective of the field before proceeding to more spe- tent on important, but rarely addressed topics. This en to pair-wise and multiple sequence alignment al- cialized topics. The book is a product of extensive first edition features all-colour-plate chapters and a gorithms, stochastic models of mutations, modulus classroom experience, and the student response to it unique continuously updated website forum where structure theory and protein configuration analysis. has been exhilarating due to its focus on problems of contributors and readers share software utilities de- Strong links to the molecular structures of proteins, contemporary interest such as cancer, genetics and scribed herein including a limited license version of DNA and other biomolecules and their analyses are aging. A unique feature of the book is its integration the imaging platform management software “PPMS” developed. In particular, for proteins an in-depth ex- of a computer algebra system into the flow of ideas, version 1.0 release, plus relevant new publications position of secondary structure predicition methods in a supporting but unobtrusive role. Syntax for both and links to other important resources. The philoso- should be a valuable tool in both molecular biology the Maple and Matlab systems is provided in a side- phy of this volume is to provide student, researcher, and in applications to rational drug design. The book by-side format. The use of a computer algebra sys- PI, professional or provost the means to enter this can also be used as textbook and for this reason most tem gives students the opportunity to examine "what applications field with confidence, and to construct of the chapters include exercises and [..] if” scenarios, thereby [..] the means to answer their own [..]

Features Features Features Clearly explains the mathematical concepts be- Revision of successful Birkhäuser book (1996), An Presents a unique selection of methods and appli- hind bioinformatics. Makes direct connections to Introduction to the Mathematics of Biology Cross- cations orientated chapters on topics of interest for biomolecular structures such as proteins, DNA and disciplinary, can be used as a textbook in courses in anyone involved in live cell microscopy Includes in- RNA. both mathematics and biology departments formation that will impact both novice and expert alike Chapter content ranges from the basic through Contents Contents to complex overview of method and protocols Also Outline.- Part I: Mutations and alignments.- Intro- 1. Biology, Mathematics and a Mathematical Biol- includes practical and detailed "how-to" content on duction.- Stochastic models of mutations and struc- ogy Laboratory.- 2. Some Mathematical Tools.- 3. important, but rarely addressed topics ture analysis.- Modulus structure theory.- Super Reproduction of the Drive for Survival.- 4. Interac- pairwise alignment.- Multiple sequence alignment.- tions Between Organisms and Their Environment.- Fields of interest Network structures of multiple sequences induced by 5. Age-Dependent Population Structures.- 6. Ran- Cell Biology; Biochemistry, general; Biological Mi- mutation.- Alignment space.- Part II: Protein con- dom Movements in Space and Time.- 7. The Biolog- croscopy; Biotechnology; Physical Chemistry figuration analysis.- Background information con- ical Disposition of Drugs and Inorganic Toxins.- 8. cerning the properties of proteins.- Informational Neurophysiology.- 9. The Biochemistry of Cells.- 10. Target groups and statistical iterative analysis of protein secondary A Biomathematical Approach to HIV and AIDS.- Institutes, libraries, scientists structure prediction.- 3D structure analysis of the 11. Parasites and Their Diseases.- 12. Genetics.- 13. Type of publication protein backbone and side chains.- Alignment of pri- Cancer—A Disease of the DNA.- 14. Genomics.- 15. Contributed volume mary and 3D structures of [..] Phylogenetics.

Fields of interest Fields of interest Due October 2007 Bioinformatics; Proteomics; Genetics and Population Mathematical Biology in General; Computer Appl. Dynamics; Human Genetics; Biophysics in Life Sciences; Probability Theory and Stochastic 2007. XXII, 450 p. 138 illus., 82 in color. (Principles and Practice) Processes; Applications of Mathematics; Computer Hardcover Target groups Applications Advanced students, scientists 139,95 € Target groups ISBN 978-3-540-71330-2 Type of publication Advanced undergraduate and graduate students Graduate/advanced undergraduate textbook studying mathematics or biology

Due February 2008 Type of publication Graduate/advanced undergraduate textbook

2008. Approx. 460 p., 47 illus. (Biological and Medical Physics, Biomedical Engineering) Hardcover Due July 2008

139,95 € Originally published by Birkhäuser Boston, 1996 ISBN 978-3-540-74890-8

2008. Approx. 430 p. 156 illus. Hardcover

39,95 € ISBN 978-0-387-70983-3 springer.com/booksellers Life Science 119

O. Shoseyov, The Institute of Plant Sciences and Genetics in Agri- H. Siebert, Kiel Institute of World Economics, Kiel, Germany A.P.J.M. Siebes, Utrecht University, Utrecht, The Netherlands; culture, Jerusalem, Israel; I. Levy, The Institute of Plant Sciences M.R. Berthold, University of Konstanz, Germany; R.C. Glen, Uni- and Genetics in Agriculture, Jerusalem, Israel (Eds.) versity of Cambridge, UK; A.J. Feelders, Utrecht University, Economics of the Environment Utrecht, The Netherlands (Eds.)

NanoBioTechnology Theory and Policy COMPLIFE 2007 BioInspired Devices and Materials of the Future The Third International Symposium on Computational Life The book interprets nature and the environment as Sciences a scarce resource. It offers a theoretical study of the NanoBioTechnology: BioInspired Devices and Ma- allocation problem and describes different policy terials of the Future is a groundbreaking text that approaches to the environmental problem. The en- The focus of the symposium is on computational will assist scientists and students in learning the fun- tire spectrum of the allocation issue is studied: the methods for modeling, analysis, and exploration of damentals and cutting-edge nature of this new and use of the environment in a static context, interna- all aspects of life sciences, ranging from effects on the emerging science. Focusing on materials and build- tional and trade aspects of environmental allocation, molecular level to complex interactions networks. ing blocks for nanotechnology, leading scientists regional dimensions, global environmental media, Of prime importance for this truly interdisciplinary from around the world share their knowledge and environmental use over time and under uncertain- event is the integration of the three disciplines: Com- expertise in this authoritative volume. The volume is ty. The book incorporates a variety of economic ap- puter Science, Biology, and Chemistry. These pro- broken into five sections. The first section presents proaches, including neoclassical analysis, the pub- ceedings contains contributions regarding appli- an overview of nanotechnology and describes the lic-goods approach, benefit-cost analysis, proper- cations aspects as well as new theoretical develop- many aspects of the field. Section 2 details biological ty-rights ideas, economic policy and public-finance ments. materials serving as nanotemplates for bottom-up reasoning, international trade theory, regional sci- fabrication. Section 3 covers the use of biological ence, optimization theory, and risk analysis. The Fields of interest macromolecules for electron transfer and compu- different aspects of environmental allocation are Computer Applications in Chemistry; Bioinformat- tation. Section 4 presents a brief overview of the ex- studied in the context of a single model that is used ics; Life Sciences, general; Computer Appl. in Life tensive and rapidly growing field of nanomedicine. through the book. Sciences Finally, Section 5 details de-novo designed structures and the various approaches different scientif- Features Target groups ic groups take with molecular level training and lan- Standard title on environmental economics With a Researchers and practitioners working in the area of guage. comprehensive presentation of allocation theory and computational life science and bioinformatics environmental policy approaches New edition with Features updated data and additional topics Type of publication Groundbreaking investigation into the recent ad- Proceedings vances and future direction of nanobiotechnology Contents Experimental strategies used by leaders at the cut- Introduction: The Problem.- Using the Environment Due October 2007 ting-edge of the field Holds interest for researchers - An Allocation Problem.- Static Allocation Aspect: in a variety of fields, from engineering to physics and Production Theory and Transformation Space.- Op- chemistry to biology timal Environmental Use.- Environmental Quali- 2007. CD-ROM. (AIP Conference Proceedings, Vol. 940) ty as a Public Good.- Property-Rights Approach to Contents the Environmental Problem.- Environmental-Poli- 60,85 € Nanobiotechnology Overview.- Experimental Strate- cy Instruments: Incidence of an Emission Tax.- Poli- ISBN 978-0-7354-0453-3 gies Towards the Use of the Porin MspA as a Nan- cy Instruments.- Policy Instruments and the Casuis- otemplate and for Biosensors.- Bionanotechnolo- tics of Pollution.- The Political Economy of Environ- gy and Bonanoscience of Artificial Bioassemblies.- mental Scarcity.- Environmental Allocation in Space: Genetically Engineered S-Layer Proteins and S-Lay- Environmental Endowment, Competitiveness and er-Specific Heteropolysaccharides as Components Trade.- Transfrontier Pollution.- Global [..] of a Versatile Molecular Construction Kit for Appli- cations in Nanobiotechnology.- Photoinduced Elec- Fields of interest tron Transport in DNA: Towards Electronic Devices Environmental Economics; Environmental Manage- Based on DNA Architecture.- Effective Models for ment Charge Transport in DNA Nanowires.- Optimizing Photoactive Proteins for Optoelectronic Environ- Target groups ments by [..] Researchers, graduate students

Fields of interest Type of publication Biotechnology; Nanotechnology; Biochemistry, gen- Graduate/advanced undergraduate textbook eral Due January 2008 Target groups Nanobiotechnologists, biologists, chemists, material scientists 2008. Approx. 330 p. Hardcover

Type of publication 79,95 € Contributed volume ISBN 978-3-540-73706-3

Due December 2007

2008. Approx. 500 p. 204 illus. Hardcover

114,95 € ISBN 978-1-58829-894-2 120 Life Science springer.com/booksellers

A.P.J.M. Siebes, Utrecht University, Utrecht, The Netherlands; J.B. Silver, United Nations, New York H. Silverman, University of Illinois, Urbana, IL, USA; W. Isbell, M.R. Berthold, University of Konstanz, Germany; R.C. Glen, Uni- State University of New York, Binghampton, NY, USA (Eds.) versity of Cambridge, UK; A.J. Feelders, Utrecht University, Utrecht, The Netherlands (Eds.) Mosquito Ecology Andean Archaeology III Field Sampling Methods COMPLIFE 2007 North and South

The Third International Symposium on Computational Life Sciences Mosquito Ecology: Field Sampling Methods is the Third Edition of this popular reference work, origi- This book is intended to continue the dynamic, cur- nally devised and written by Professor M W Service rent problem-oriented approach to the field of An- and now updated by John B Silver. The purpose of dean Archaeology that started with Andean Archae- The focus of the symposium is on computational the third edition is in keeping with the original vi- ology I and Andean Archaeology II. In this volume, methods for modeling, analysis, and exploration of sion of Professor Service to describe the methods the strong cultural differences between northern and all aspects of life sciences, ranging from effects on the and rationale for sampling mosquitoes, with particu- southern regions of the Central Andes are examined molecular level to complex interactions networks. lar emphasis on the ecology and behaviour of those and the conditions under which these differences Of prime importance for this truly interdisciplinary species that play a role as vectors of human and ani- evolved are explored. Andean Archaeology III com- event is the integration of the three disciplines: Com- mal diseases and infections. The book is designed to bines up-to-date research, diverse theoretical plat- puter Science, Biology, and Chemistry. These pro- serve as a practical reference for field entomologists forms, and far-reaching interpretations. ceedings contains contributions regarding appli- and mosquito control specialists and describes the cations aspects as well as new theoretical develop- sampling methods and available trapping technolo- Features ments. gies and tools for the collection of all life-stages of As the third volume in the Andean Archaeology set, the focus is on the strong cultural differences be- Fields of interest mosquitoes, from egg to adult. It also describes the tween the northern and southern regions of the Cen- Computer Applications in Chemistry; Bioinformat- techniques available for data analysis and discusses tral Andes and to consider the under which differ- ics; Life Sciences, general; Computer Appl. in Life ecological principles of relevance to the study of field ences evolved and which were diminished As we cur- Sciences populations of mosquitoes. While concentrating primarily on mosquitoes, many of the techniques de- rently see in any large geographic and/or political Target groups scribed are suitable for the study [..] region (the United States, the European Union) the Researchers and practitioners working in the area of identification and understanding of the different cul- computational life science and bioinformatics Features tures [..] Extensively revised with significant additional infor- Type of publication mation provided and considerable re-structuring of Contents Proceedings the chapters and layout More than 1000 new refer- Introduction: Regional Patterns.- The North: Intro- ences have been added and out-of-date material has duction.- America’s First City? The Case of Late Ar- chaic Caral.- Religious Warfare at Chankillo.- The Due October 2007 been removed A more detailed table of contents and comprehensive index will assist the reader in quickly Vicus-Mochica Relationship.- Competitive Feast- locating the sections of particular interest to her/him ing, Religious Pluralism and Decentralized Power 2007. Approx. 190 p. (AIP Conference Proceedings, Vol. 940) in the Late Moche Period.- Northern Exposures: Hardcover Fields of interest Recuay-Cajamarca Boundaries and Interaction.- Animal Ecology; Zoology; Parasitology; Invertebrates Chimu Craft Specialization and Political Economy: 65,45 € A View from the Provinces.- The South: Introduc- ISBN 978-0-7354-0452-6 Target groups tion.- Early Village Society in the Formative Period Field entomologists, mosquito control specialists. in the Southern Lake Titicaca Basin.- The Emergence of Complex Society in the Titicaca Basin: The View Type of publication [..] Monograph Fields of interest Due November 2007 Archaeology; Anthropology Target groups 2008. Approx. 900 p. Hardcover Archaeologists studying the Andean empire, those studying civilizations with different, comparative 245,00 € cultures within the same area ISBN 978-1-4020-6665-8 Type of publication Professional book

Due December 2007

2008. XII, 524 p. Softcover

30,80 € ISBN 978-0-387-75730-8 springer.com/booksellers Life Science 121

H. Silverman, University of Illinoise, Urbana, IL, USA; W. Isbell, S. Simjee, Eli Lilly and Company Limited, Basingstoke, Hamp- J. Skibo, University of Illinois, Normal, IL; M.B. Schiffer, University State University of New York, Binghampton, NY, USA (Eds.) shire, UK (Ed.) of Arizona, Tucson, AZ

Handbook of South American Foodborne Diseases People and Things

Archaeology A Behavioral Archaeological Perspective

In Foodborne Diseases, leading authorities present a broad overview of the microbial pathogens and The Handbook of South American Archaeology has The core of archaeology is the relationship between toxins associated with foodborne illness while dis- been created as a major reference work for archae- people and things. Left without informants and, in cussing pathogenicity, clinical epidemiology, di- ologists working in South America, professors and many cases, textual data, archaeologists strive to re- agnosis, and treatment. The chapters of this vol- their upper-division undergraduate and graduate construct past life through the window of artifacts: ume cover a wide variety of bacterial students in South American archaeology courses in- things made, used, and modified by individuals while pathogens, viruses, protozoans, and parasites, as well cluding areal courses (Central Andes, North Andes, participating in the activities of everyday life. Ac- as microbial toxins, and also address alterna- tropical lowlands), archaeologists working elsewhere cording to behavioral archaeologists, our ability to tives to antibiotics, risk assessment, irradiation and in the world who want to learn about South Ameri- understand the relationship between people and other sanitation procedures, and molecular tech- can prehistory in a single volume. The contributions things in the present is the foundation for archae- niques for detecting foodborne pathogens. Addition- of this seminal handbook have been commissioned ological reconstruction of the past. This compre- ally, the acclaimed authors discuss pathogen con- from leading local and global authorities on South hensive text provides an explanation of Behavioral trol strategies and look toward future innovations in America. Authors present the dynamic evolution- Archaeology by the founders of the theory. food safety technology. Covering essential foodborne ary processes of the ancient societies and principal Twenty years in the making, this work will be an pathogens, assessment and treatment, Foodborne geographical regions of the continent and consider essential tool for new scholars as well as experi- Diseases is an essential reference for infectious dis- issues such as environmental setting and ecological enced members of the field. It offers a clear ease specialists, microbiologists, and industrial and adaptations, social equality/inequality, identity for- overview of the theory of Behavioral Archaeology, research-based scientists in food safety. mation, long-distance/intercultural interaction, reli- updated with responses to criticism, and demon- gious systems and their material manifestations, ide- Features strates its application in six diverse case studies. ological orientations, and political and economic or- A broad overview of microbial pathogens and tox- Features ganization as these developed over time. The volume ins Summaries of proven and novel control strategies -Definitive guide to the theory of Behavioral Archae- [..] and treatments Chapters written by leading authori- ology -First time these six diverse case studies have ties on foodborne illness Features been published together -Compares and contrasts The most comprehensive coverage of the South Contents Behavioral Archaeology with other prevailing theo- American continent The biggest names in South E. coli.- Listeria.- Clostridium.- Yersinia.- Vib- retical models to fully explain the theory American archaeology and anthropology from rio.- Enterococcus.- Viral Hepatitis.- Gastroenter- Contents around the globe Organized to bring researchers of ic Virus.- Cryptosporidium.- Toxoplasma.- Aflatox- Introduction: People and Things.- Behavior, Selec- specific areas to awareness of other cultures and his- ins.- Scombroid poisoning.- HAACP.- Use of An- tion, Agency, Practice, and Beyond.- Exploring the tories of the continent timicrobials in Food Animal Production.- Alterna- Origins of Pottery on the Colorado Plateau.- Smudge tives to Antibiotics.- Risk Assessment.- Irradiation Contents Pits and Hide Smoking Revisited.- The Devil is in the and other sanitation procedures.- Molecular tech- Foreword by Norman Yoffee.- Continental Intro- Details: The Cascade Model of Invention Processes.- niques of detecting foodborne pathogens and their duction.- Profiles in Pleistocene History.- Chinchor- Ball Courts and Ritual Performance.- Social Theory toxins.- Future Directions in Food Safety. ro Culture: Pioneers of the Coast of the Atacama and History in Behavioral Archaeology.- Studying Desert.- Early Occupations in the Southern Cone.- Fields of interest Technological Differentiation. The Process of Sedentism in Northwestern South Infectious Diseases; Microbiology; Gastroenterology; Fields of interest America.- Central Andean Environments.- Plant Pharmacology/Toxicology Domestication and the Shift to Agriculture in the Archaeology; Anthropology Andes.- Animal Domestication in South America.- Target groups Target groups High Elevation Foraging Societies.- Early Fishing So- Infectious disease specialists, microbiologists, in- Academic archaeologists, archaeological theo- cieties in Western South America.- Amazonia: The ternists, toxicologists Historical Ecology of a Domesticated Landscape.- rists, graduate-level archaeology students The Archaeology of Agriculture in Ancient Amazo- Type of publication Type of publication nia.- [..] Contributed volume Graduate/advanced undergraduate textbook Fields of interest Due October 2007 Archaeology; Anthropology Due August 2008

Target groups 2007. Approx. 655 p. 30 illus., 4 in color. (Infectious Disease) Archaeologists and cultural heritage managers Hardcover 2008. Approx. 250 p. (Manuals in Archaeological Method, Theory and Technique) Hardcover (on site or in a museum) who work in or on South 114,95 € American cultures 69,30 € ISBN 978-1-58829-518-7 ISBN 978-0-387-76524-2 Type of publication Handbook

Due April 2008

2008. Approx. 945 p. Hardcover

134,75 € ISBN 978-0-387-74906-8 122 Life Science springer.com/booksellers

B. Sobolev, University of British Columbia, Vancouver, BC, Cana- G. Stacey, University of Missouri, Columbia, MO, USA (Ed.) M.P. Starkey, Animal Health Trust, Newmarket, Suffolk, UK; R. da; L. Kuramoto, Vancouver Coastal Health Research Institute, Elaswarapu, Oxford Gene Technology (Operations) Ltd., Oxford, Vancouver, BC, Canada UK (Eds.) Genetics and Genomics of Soybean Analysis of Waiting-Time Data in Genomics Protocols Health Services Research The Fabaceae (leguminosae) comprise the second 2nd Edition largest family of flowering plants with 650 genera and 18000 species. The soybean is a member of the Why some patients wait longer than others re- tribe Phaseoleae, the most economically important Since the first edition, published in 2001, genomics mains an important question in health services re- of the legume tribes. The soybean, Glycine max (L.) research has taken great strides. In Genomics Proto- search. This book is a reference for health services Merr. is the major source of vegetable oil and protein cols, 2nd Edition, a team of expert researchers share researchers looking for statistical tools with which on earth. Soybean oil has garnered considerable re- the most current information in a field that has re- to study waiting times. The book provides detailed cent attention due to its increased use for biodiesel cently switched emphasis from gene identification coverage of statistical concepts and methods for the production. The extensive genetic resources of soy- to functional genomics and the characterization of analysis and interpretation of waiting-time data: bean and the associated physiological tools available genes and gene products. This volume approaches time-to-event analysis, discrete time regression mod- present a set of unique opportunities to study every- its complex subject with a broad perspective to sup- els, competing risks, and pseudovalues regression thing from seed development to the biology of poly- ply its reader with a vital overview of genomics and models. The book will also be useful for profession- ploidization to a huge array of pathogenic and sym- its derivative fields, with a focus on pivotal issues als and research workers in health care industry, who biotic plant-host interactions. The large plant size of such as data analysis. Following the highly success- will find a collection of examples of waiting-time da- soybean is an advantage for such studies, permitting ful Methods in Molecular Biology™ series format, the ta analysis in health services research. It gives a prac- the use of techniques not easy or possible with small- chapters provide easy-to-follow laboratory proto- tical perspective on how to describe and compare er plants. For these and additional reasons, soybean cols, lists of the necessary materials, and the excellent waiting experiences, how to study the impact of fac- genomic research has seen major advances in recent Notes section, which offers tips on troubleshooting tors associated with waiting times, and how to use years. Therefore, a book chronicling these advances and avoiding known pitfalls. Expansive and current, appropriate statistical techniques in practical terms, and the potential for future [..] Genomics Protocols, 2nd Edition is the perfect up- i.e., from a study question through interpretation of date for researchers working in this integral, growing Features results. field. A comprehensive and timely reference on soybean Features genomics. The only genomic resource of consid- Features analysis from health services research erable interest to practicing plant biologists and Unparalleled diversity of technologies covered in a perspective, rather than operations manage- geneticists, graduate and undergraduate students, single volume ment and research professionals such plant breeders and germplasm curators who work on or are interested Contents Contents in legume species. Soybean genomics is of great in- Whole Genome Amplification with Phi29 DNA Part I: Data and Methods.- Health services research terest in all parts of the world as one of the most eco- Polymerase to enable Genetic or Genomic Analysis on access to care.- Waiting-time data used in this nomically [..] of Samples of Low DNA Yield.- Scanning for DNA book.- Statistical methods.- Part II: Waiting-time variants by denaturant capillary electrophoresis.- Studies.- Overview of waiting times and other vari- Contents Identification of SNPs, or Mutations in Sequence ables.- Variation and access probabilities.- Factors Forward.- Soybean as a crop plant.- Soybean Genet- Chromatograms.- Beadarray based Genotyping.- Mi- influencing waiting times.- Surgery after target ac- ic Diversity.- Soybean Genetic Map.- Soybean Physi- crosatellite-Based Candidate Gene Linkage Analysis cess time.- Adverse events while waiting.- Intermedi- cal Map.- Elucidating soybean genome structure by Studies.- Full Complexity Genomic Hybridization on ate events.- Survival benefit of CABG.- Part III: Ap- fluorescent in-situ hybridization.- Sequencing the 60mer Oligonucleotide Microarrays for Array Com- pendices.- Other data dictionaries.- SAS code.- Mat- soybean genome.- Soybean Transformation.- Soy- parative Genomic Hybridization (aCGH).- Detection lab code. bean Breeding.- Forward and reverse genetics in soy- of Copy Number Changes at Multiple Loci in DNA bean.- Legume Comparative Genomics.- Phaseolus Prepared from Formalin Fixed, Paraffin-Embedded Fields of interest vulgaris: A diploid model for soybean.- Genomics of Tissue by [..] Health Care Administration; Statistics for Life Sci- soybean seed development.- Genomics of soybean ences, Medicine, Health Sciences; Health Adminis- oil traits.- Genomics of soybean secondary Fields of interest tration; Health Informatics & Health Administration metabolism.- Genomics of Fungal-soybean interac- Human Genetics; Cell Biology; Biotechnology tions.- Genomics of Insect-soybean interactions.- [..] Target groups Target groups researchers and graduate students in health Fields of interest Geneticists, molecular and cellular biologists services research; health administrators Plant Genetics & Genomics; Plant Pathology; Plant Sciences; Food Science Type of publication Type of publication Contributed volume Monograph Target groups The primary market will be researchers, institutes, Due March 2008 Due April 2008 and students in Plant Genetics and Genomics, Plant biology, Plant pathology, Agronomy, and Food sciences. 2008. Approx. 530 p, 115 illus 4 in color (Methods in Molecular 2008. Approx. 250 p. Hardcover Biology, Vol. 439) Hardcover Type of publication 61,60 € 79,95 € Contributed volume ISBN 978-0-387-76421-4 ISBN 978-1-58829-871-3

Due January 2008

2008. Approx. 500 p. (Plant Genetics and Genomics: Crops and Models, Vol. 2) Hardcover

99,35 € ISBN 978-0-387-72298-6 springer.com/booksellers Life Science 123

J.D. Stednick, Colorado State University, Fort Collins, CO, USA ISBN 978-0-387-94385-5 K. Stigter, Agromet Vision, The Netherlands (Ed.) (Ed.) Applied Agrometeorology Hydrological and Biological Responses to Forest Practices

The Alsea Watershed Study This handbook reviews regional operational applications of agrometeorology in the form of case studies of agrometeorological services and information that prepare farmers of different income The camaraderie of George Ice and Ben Stout levels for extreme weather and climate events (NCASI) in particular made for an enjoyable leave and for the use of weather and climate "windows and I want to acknowledge the late Hank Froehlich of opportunity" under conditions of a changing and Jim Kiser (OSU) for our discussions on what climate. In a review of operational agrom- does it all mean. My plan was to finish this book eteorological knowledge, fields of application will at OSU, but that opportunity was not presented. be covered: crops (for which aspects of soils, pests, Nonetheless, the book took longer to complete than diseases, water, fertilizers and labour are dis- I originally thought. The interest by other investi- cussed, in so far as their interaction with agrome- gators and new support prompted me to not let the teorological factors), forestry, livestock, and fish- perfect be the enemy of the good. It was my final de- eries, and all with an emphasis on applications cisions that went to press, thus, any errors or omis- of current knowledge. Supportive sions are my responsibility not authors or reviewers. methods that are operationally applied are re- This book does not completely cover all the lessons viewed and exemplified through case studies learned. Even with the conveniences of modern sci- of their applications in the above mentioned fields. ence, data loggers fail, water level floats leak, and wa- This applies to field quantifications, modelling, deci- ter quality samples disappear between the field and sion-support systems, remote sensing, geographic in- the lab. Those are the lessons that have to be experi- formation systems and other [..] enced to be learned, or shared over a beer. This compilation may not recognize all the people who con- Features tributed to efforts in the Alsea watersheds but [..] Combination of the theoretical background of agricultural meteorology with practical probblem solving Features and case studies and as such appealing to both scien- Contains information gleaned from the original tists, end users (farmers) and policy makers. Alsea Watershed Study and the “new” study of 20 years later Includes analyses and syntheses of oth- Contents er relevant work, much of which originated from Introduction.- Regional operational applications of questions generated by the original study Represents agrometeorology.- Fields of application in agrome- the cooperative effort of many scientists from sever- teorology.- Methods successfully applied in applica- al disciplines. It comes at a time when mangers and tions leading to agrometeorological services policy makers are searching for ways to restore the runs of [..] Fields of interest Meteorology/Climatology; Agriculture; Applied Geo- Contents sciences; Environmental Management; Forestry; Cli- The Alsea Watershed Study: Hydrological and Bio- mate Change logical Responses to Forest Practices.- 1. The Alsea Watershed Study.- 2. Effects of Timber Harvest- Target groups ing on Streamflow in the Alsea Watershed Study.- Agricultural meteorologists and other agri- 3. Stream Temperature and Dissolved Oxygen.- 4. cultural scientists; agricultural consultants and ex- Sediment Studies in the Alsea Watershed Study.- tensionists; intermediaries between weather and cli- 5. Salmonid Populations and Habitat.- 6. The Ore- mate products of NMHSs, Research Institutes, Uni- gon Forest Practices Act and Forest Research.- 7. versities, Commercial Groups and the end users in The New Alsea Watershed Study.- 8. Flynn Creek: the agricultural sectors; undergraduate and graduate Research Natural Area.- 9. Long Term Streamflow agrometeorology students Changes Following Timber Harvesting.- 10. Long Term Water Quality Changes Following Timber Type of publication Harvesting.- 11. [..] Monograph

Fields of interest Due December 2008 Ecology; Forestry Management; Environmental Management; Nature Conservation; Ecosystems; 2009. Approx. 420 p. Hardcover Waste Water Technology / Water Pollution Con- trol / Water Management / Aquatic Pollution 149,95 € ISBN 978-3-540-74697-3 Target groups Natural resource managers, land managers, water and fishery researchers

Type of publication Contributed volume

Due December 2007

2008. Approx. 410 pp. 130 figs. (Ecological Studies, Vol. 199) Hardcover

95,00 € 124 Life Science springer.com/booksellers

T.S. Stoinski, Dian Fossey Gorilla Fund International, Atlanta, GA, D. Sugden, King’s College London (Ed.) H. Sun, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA (Ed.) USA; H.D. Steklis, Rutgers University, New Brunswick, NJ, USA; P.T. Mehlman, Dian Fossey Gorilla Fund International, Atlanta, GA, USA (Eds.) Real Time PCR Retinoids

Conservation in the 21st Century:

Gorillas as a Case Study Fields of interest Fields of interest Biochemistry, general Cell Biology; Nutrition; Oncology

Like other fields of science, wildlife conservation is Type of publication Type of publication a changing field. Threats facing wild populations Contributed volume Contributed volume of apes and other species, say 20 years ago, are likely not the same ones most pressing today, and even Due January 2009 Due August 2009 where threats have remained unchanged, more effective means of addressing them may be available now. 2008. 400 p. (Methods in Molecular Biology, Preliminary entry 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Conservation scientists have learned from many 2134) Hardcover entry 2243) Hardcover years of experience, and both theoretical and technological advances today provide conservation tools 74,95 € 76,65 € not available in the past. This volume identifies the ISBN 978-1-58829-819-5 ISBN 978-1-60327-324-4 primary problems faced in conserving wild populations of gorillas throughout Africa, pinpointing new approaches to solving these problems and outlining the increased role that zoos can play in gorilla conservation. It includes expertise of field scientists in a variety of disciplines to discuss current conservation threats, novel approaches to conservation, and potential solutions.

Features Can serve as a “conservation handbook” for a variety of species, as well as providing specific information on current conservation issues faced by gorillas in the wild

Contents Current state of wild gorilla populations.- An experiment in managing the human animal: The PHVA process and its role in conservation decision-making.- Approaches to corridor planning: Transition- ing TAMARIN from Mata Atlantica to Madagascar.- Conservation medicine for gorilla conservation.- Linking the Community Options, Assessment and Investment Tool (COAIT), Consensys™ and Payment for Environmental Services (PES): A model to promote gorilla conservation in Africa.- Biomaterials in gorilla research and conservation.- An integrated ge- omatics research program for mountain gorilla [..]

Fields of interest Evolutionary Biology; Zoology

Target groups Researchers, scientists, professionals, and graduate students in the fields of primatology, physical anthropology, zoology and animal behavior

Type of publication Monograph

Due November 2007

2007. Approx. 550 p. (Developments in Primatology: Progress and Prospects) Hardcover

96,95 € ISBN 978-0-387-70720-4 springer.com/booksellers Life Science 125

A. Szallasi, Monmouth Medical Center, Long Branch, NJ, USA (Ed.) R. Tarté, Kraft Foods Inc., Madison, WI, USA (Ed.) D. Teare, University of Sheffield, Sheffield, UK (Ed.)

Analgesia Functional Ingredients in Meat Genetic Epidemiology Products

This volume offers comprehensive coverage of molecular analgesia research methods from target Fields of interest This book discusses not only the basic ingredi- discovery through target validation and clinical test- Human Genetics; Statistics for Life Sciences, ents that are traditionally used in meat products, but ing to tolerance and dependence. Emerging receptor Medicine, Health Sciences; Molecular Medicine also novel and emerging ingredients, where much classes as targets for analgesic drugs and innovative basic research work is still being done. The basic analgesic strategies are discussed in separate chap- Target groups chemistry of each type of ingredient is presented, as ters. From the molecular research bench through the Epidemiologists, statisticians, and non-statisticians well as the advantages and disadvantages of each. animal laboratory to the bed-side, this book is for all who want to understand more about aspects of inter- This work is a single reference volume of the current those scientists and clinicians who are interested in pretation and subtle distinctions in study design state-of-knowledge as it relates to this area. The con- what the increasingly molecular future has in store tributions are technical in nature, but at the same Type of publication for analgesia research. time, are of practical value to the meat processing in- Contributed volume Fields of interest dustry at large, especially those involved in product Cell Biology; Pharmacology/Toxicology development and formulation. Due October 2009

Target groups Features The first single volume devoted solely and exclusive- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary Molecular and cellular biologists, scientists, and clin- entry 2270) Hardcover icians ly to the use of functional non-meat ingredients in the formulation, development and manufacturing of 76,65 € meat products Describes the fundamental concepts Type of publication ISBN 978-1-60327-415-9 Contributed volume that govern the functional behavior of non-meat ingredients in meat systems Presents the latest meat- related research on each type of ingredient Contains Due September 2009 practical, science-based, information that will help [..] 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary entry 2249) Hardcover Contents Introduction: The role of functional ingredients in 76,65 € meat products.- Basic ingredients.- Starch- ISBN 978-1-60327-322-0 es.- Non-starch hydrocolloids.- Plant fibers.- Plant proteins.- Dairy proteins.- Meat-derived ingredients.- Enzymes.- Flavor- ing agents & flavor enhancers.- Culinary ingredients.- Sweeteners and bulking agents.- Fermentation/acidification ingredients.- Coatings.- Antioxidants.- Antimicrobial ingredients.- Ingredient synergistic interactions: a systems approach.- Enhanced meats.- Alternative curing systems.- Regula- tory status of [..]

Fields of interest Food Science

Target groups 1. Food science/meat science researchers, educators and students (particularly those with an interest in meat science and meat processing 2. Technical personnel working in the meat processing and ingredient supplier industries. 3. Personnel in government who deal with the regulation of the use of non-meat ingredients in meat products

Type of publication Graduate/advanced undergraduate textbook

Due March 2008

2008. Approx. 700 p. Hardcover

76,25 € ISBN 978-0-387-71326-7 126 Life Science springer.com/booksellers

M. Thiriet, Université Pierre et Marie Curie, Paris, France M. Thiriet, Université Pierre et Marie Curie, Paris, France V. Thongboonkerd, Mahidol University, Bangkok, Thailand (Ed.)

Biology and Mechanics of Blood Biology and Mechanics of Blood Proteomics of Human Body Fluids

Flows Flows Principles, Methods, and Applications Part II: Mechanics and Medical Aspects Part I: Biology

This volume is the first collection of applications of proteomics to analyze various human body flu- Biology and Mechanics of Blood Flows presents the Biology and Mechanics of Blood Flows presents the ids. Proteomics of Human Body Fluids consists of basic knowledge and state-of-the-art techniques nec- basic knowledge and state-of-the-art techniques nec- two parts: the first provides basic principles and essary to carry out investigations of the cardiovascu- essary to carry out investigations of the cardiovas- strategies for proteomic analysis of human body flu- lar system using modeling and simulation. Part II of cular system using modeling and simulation. Part I ids, while the second offers more details regarding this two-volume sequence, Mechanics and Medical of this two-volume sequence, Biology, addresses the methodologies and recent findings and clinical appli- Aspects, refers to the extraction of input data at the nanoscopic and microscopic scales. The nanoscale cations of each specific type of human body fluids. macroscopic scale for modeling the cardiovascular corresponds to the scale of biochemical reaction system, and complements Part I, which focuses on cascades involved in cell adaptation to mechanical Features nanoscopic and microscopic components and pro- stresses among other stimuli. The microscale is the The first collection of applications of proteomics to cesses. This volume contains chapters on anatomy, scale of stress-induced tissue remodeling associated analyze various human body fluids Provides basic physiology, continuum mechanics, as well as patho- with acute or chronic loadings. The cardiovascular principles and strategies for proteomic analysis of logical changes in the vasculature walls including the system, like any physiological system, has a compli- human body fluids Offers more details regarding heart and their treatments. Methods of numerical cated three-dimensional structure and composition. methodologies and recent findings simulations are given and illustrated in particular by Its time dependent behavior is regulated, and this application to wall diseases. This authoritative book complex system has many components. In this au- Contents will appeal to any biologist, chemist, physicist, or ap- thoritative work, the author provides a survey of rel- From the contents Part I: Principles of Proteomics plied mathematician interested in the functioning of evant cell components and processes, with detailed Applied to Human Body Fluids.- 1. Proteomic the cardiovascular system. coverage of the electrical and mechanical behaviors Strategies for Analyzing Body Fluids.- 2. Sample of vascular cells, tissues, and organs. Because the be- Preparation of Body Fluids for Proteomics Analy- Features haviors of vascular cells and tissues are [..] sis.- 3. Multiplexed Immunoassays for Protein Profil- Multidisciplinary approach starting from the de- ing in Human Body Fluids.- 4. Deciphering the Hi- scription of accumulated knowledge on the biology Features eroglyphics of Functional Proteomics Using Small of the cardiovascular system to the numerical simu- Multidisciplinary approach starting from the de- Molecule Probes.- 5. Modification-Specific Pro- lation of flows in the vasculature, incorporating rhe- scription of accumulated knowledge on the biology teomic Analysis of Glycoproteins in Human Body ology and mechanical data Applications of modeling of the cardiovascular system to the numerical simu- Fluids by Mass Spectrometry.- 6. Plasma Proteome and simulations on health problems as well as ther- lation of flows in the vasculature, incorporating rhe- Database.- 7. 2-D PAGE Databases for Proteins in apeutic strategies State of the art in applied mathe- ology and mechanical data Applications of modeling Human Body Fluids.- 8. Bioinformatics and Experi- matics to physiological flows Biological and mechan- and simulations on health problems as well as ther- mental Design [..] ical [..] apeutic strategies State of the art in applied mathematics to physiological flows Biological and mechan- Fields of interest Contents ical [..] Biochemistry, general; Cell Biology; Pharmacolo- Introduction.- Anatomy of the Cardiovascular Sys- gy/Toxicology tem.- Cardiovascular Physiology.- Images, Signals Contents and Movements.- Rheology.- Hemodynamics.- Nu- Introduction.- The Cell.- Plasma Membrane and Cell Target groups merical Simulations.- Cardiovascular Diseases.- Environment.- Ion Carries and Receptors.- Signal- Pharmacologists, toxicologists, molecular and cell bi- Treatments of Cardiovascular Diseases.- Conclusion. ing Pathways.- Transport and Cell Motion.- Blood.- ologists, biochemists A) Anatomical, Biological, Medical Glossaries. B) Heart Wall.- Vessel Wall.- Endothelium.- Tissue Adipocyte. C) Basic Aspects in Mechanics. D) Nu- Growth, Repair and Remodeling. Concluding Re- Type of publication merical Simulations. marks. A) Endocrine System and Hormones. B) Co- Contributed volume agulation Factors. C) Basic Mechanics. D) Numerical Fields of interest Simulations. Due October 2007 Biophysics; Biomedical Engineering; Cardiology; Continuum Mechanics and Mechanics of Materials Fields of interest Biophysics; Biomedical Engineering; Cardiology; 2007. 553 p. 103 illus., 7 in color. Hardcover Target groups Continuum Mechanics and Mechanics of Materials Researchers in Biomechanics, Fluid Mechanics, Ap- 134,95 € plied Mathematics, and Biology/Medicine Target groups ISBN 978-1-58829-657-3 Researchers in Biomechanics, Fluid Mechanics, Ap- Type of publication plied Mathematics, and Biology/Medicine Monograph Type of publication Due January 2008 Monograph

2008. Approx. 460 p. 40 illus. (CRM Series in Mathematical Due December 2007 Physics) Hardcover 2008. Approx. 460 p. 60 illus. (CRM Series in Mathematical 99,35 € Physics) Hardcover ISBN 978-0-387-74848-1 99,35 € ISBN 978-0-387-74846-7 springer.com/booksellers Life Science 127

J. Tombran-Tink, Penn State College of Medicine, Hershey, PA, Th. Traut, University of North Carolina, Chapel Hill, NC, USA R.J.A. Trent, Royal Prince Alfred Hospital, Camperdown, Australia USA; C.J. Barnstable, Penn State College of Medicine, Hershey, (Ed.) PA, USA (Eds.) Regulatory Allosteric Enzymes Clinical Bioinformatics Ocular Transporters in Ophthalmic Diseases and Drug Delivery All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by With the ever-increasing volume of information in more than a billion-fold. Allosteric enzymes are even clinical medicine, researchers and health profession- This exceptionally important new work represents more amazing because the have the additional ability als need computer-based storage, processing and dis- recent discoveries and advancements in the study of to change their rate in response to cellular activators semination. In "Clinical Bioinformatics", leading ex- ocular transporters and their roles in ocular physi- or inhibitors. This enables them to control the path- perts in the field provide a series of articles focus- ology, pathology, and drug delivery. Transporters way in which they are the regulatory enzyme. Since ing on software applications used to translate infor- are found on the membranes of cells and play a key the effector molecules represent the current status of mation into outcomes of clinical relevance. Cover- role in transmitting signals between cells. In Ocu- the cell for a given metabolic pathway, this results in ing such topics as gene discovery, gene function (mi- lar Transporters in Ophthalmic Diseases and Drug very responsive and balanced metabolic states, and croarrays), DNA mutation analysis, proteomics, on- Delivery, a panel of distinguished authors discuss- makes it possible for cells and organisms to be ap- line approaches and resources, and informatics in es all the latest developments in the study of ocular propriately dynamic, and responsive, in a changing clinical practice, this volume concisely yet thorough- transporters. Focusing on the molecular character- environment. This book provides a logical introduc- ly explores its cutting edge subject. In this emerging istics, localization, and substrate specificities in var- tion to the limits for enzyme function as dictated by "omics" era, "Clinical Bioinformatics" is the perfect ious compartments of the eye, this volume discuss- the factors that are limits for life. This book presents guide for researchers and clinical scientists to unlock es how transporters regulate the clarity of the cornea a complete description of all the mechanisms used the complex, dense, and ever-growing accumulation and lens, the movements of fluids across the ciliary for changing enzyme acticity. Eight enzymes are of medical information. epithelium and nutrients across the retinal pigment used as model systems after extensive study of their Features epithelium. mechanisms. Wherever possible, the human form of the enzyme is [..] Step-by-step instructions that ensure successful re- Features sults Tricks of the trade and notes on troubleshoot- Focus on the molecular characteristics, localization, Features ing and avoiding known pitfalls and substrate spevidieis in various compartments of Covers the most recent developments in the analysis Contents the eye of several classes of well-known membran of allosteric enzymes Extensively illustrated to clarify In Silico Gene Discovery.- Whole Genome Wide transporters Illustrates how mutations or dysfunc- kinetic and regulatory properties Discusses recently Association Study Using Affymetrix SNP Chip: a tion of specific transporters can contribute to vari- created crystal structures of the enzymes Provides a Two-Stage Sequential Selection Method to Identify ous disorders in the eye including blindness Exam- detailed enzyme structure for each enzyme covered Genes that Increase the Risk to Develop Complex ines how epithelial and endothelial barriers can block in the book Focuses on the features of these enzymes Diseases.- Utilizing HapMap and Tagging SNPs.- drug delivery and limit ocular availibility of drugs that are invaluable to the discussion of allosterism and regulation Measuring the Effects of Genes and Environment Contents on Complex Traits.- Microarrays – Planning your Aquaporins and water transport in the cornea.- Roles Contents Experiment.- Clinical Uses of Microarrays in Can- of Corneal Epithelial Ion Transport mechanisms General Introduction; Regulation of Metabolism.- cer Research.- Microarrays – Analysis of Signaling in mediating responses to cytokines and osmotic Overview of Enzyme Structure with emphasis on Pathways.- Microarrays – Identifying Molecular Por- stress.- Vitamin C Transport, Delivery, and Function domains, and position of catalytic sites at domain traits for Prostate Tumors with Different Gleason in the Anterior Segment of the Eye.- Mechanisms of interface or subunit interface.- Description of En- Patterns.- Microarrays for the Study of Viral Gene Aqueous Humor Formation: Cellular Model of aque- zyme Assays, with emphasis on choosing methods Expression [..] ous inflow.- Membrane Transporters: New Roles in for time.- Enzyme Kinetics.- Types of Cooperativity.- Fields of interest Lens Cataract.- Lens Na+ K-ATPase.- Pathophysi- Hemoglobin as a Model System of a classic homo– Bioinformatics; Cell Biology; Molecular Medicine; ology of Perictye-Containing Retinal Microvessels: oligomer.- Aspartate transcarbamylase, E coli, as a Proteomics; Human Genetics Roles of Ion Channels and Transporters.- Molecu- classic hetero-oligomer. Example of separate sites for positive and negative regulatory effectors.- Phos- lar mechanisms of the Inner Blood-Retinal Barrier Target groups phofructokinase.- Glycogen Phosphorylase.- Hexoki- Transporters.- Regulation of Transport in the RPE.- Geneticists, bioinformaticians, cell biologists [..] nase, yeast and rat.- [..] Type of publication Fields of interest Fields of interest Contributed volume Ophthalmology; Cell Biology Biochemistry, general; Biomedical Engineering; Cell Biology; Chemistry/Food Science, general; Target groups Biomedicine general Due January 2008 Clinicians, research scientists in academia, and the pharmaceutical industry Target groups 2008. Approx. 419 p. 89 illus. (Methods in Molecular Medicine, The primary audience for this book includes bio- Vol. 141) Hardcover Type of publication chemists, molecular biologists, cell biologists, Contributed volume chemists, biophysicists. 79,95 € ISBN 978-1-58829-791-4 Due March 2008 Type of publication Monograph

2008. Approx. 464 p. 98 illus. (Ophthalmology Research) Hard- cover Due November 2007

154,95 € 2008. Approx. 220 p. Hardcover ISBN 978-1-58829-958-1 109,95 € ISBN 978-0-387-72888-9 128 Life Science springer.com/booksellers

T. Tzfira, Dept. of Molecular, Cellular, & Developmental Biology, Ann Arbor, MI, USA; V. Citovsky, SUNY Stony Brook, Stony Brook, NY, USA (Eds.)

Agrobacterium

Agrobacterium is a plant pathogen which causes the "crown-gall" disease, a neoplastic growth that results from the transfer of a well-defined DNA segment ("transferred DNA", or "T-DNA") from the bacterial Ti (tumor-inducing) plasmid to the host cell, its integration into the host genome, and the expression of oncogenes contained on the T-DNA. The molecular machinery, needed for T-DNA generation and transport into the host cell and encoded by a series of chromosomal (chv) and Ti-plasmid virulence (vir) genes, has been the subject of numerous studies over the past several decades. Today, Agrobac- terium is the tool of choice for plant genetic engineering with an ever expanding host range that includes many commercially important crops, flowers, and tree species. Furthermore, its recent application for the genetic transformation of non-plant species, from yeast to cultivated mushrooms and even to human cells, promises this bacterium a unique place in the future of biotechnological applications. The [..]

Features The only complete overview of all aspects of agrobacterium in the plant sciences Deals with various aspects of the biology of the diseases caused by agrobacterium Covers the basics of the bacteria itself, the mapping of its genome, through to its use in plant transformation and biotechnology Delves into the questions of ethics and law in the biotechnological applications of Agrobacterium

Contents Agrobacterium: a disease-causing bacterium.- A brief history of research on Agrobacterium tumefaciens: 1900-1980.- Agrobacterium and plant biotechnology.- The Agrobacterium tumefaciens C58 genome.- Agrobacterium—taxonomy of plant- pathogenic Rhizobium species.- The initial steps in Agrobacterium tumefaciens pathogenesis: chemical biology of host recognition.- Agrobacterium-host attachment and biofilm formation.- Production of a mobile T-DNA by Agrobacterium tumefaciens.- Translocation of oncogenic T-DNA and effector proteins to plant cells.- Intracellular transport of Agrobacterium [..]

Fields of interest Plant Sciences; Plant Genetics & Genomics; Plant Pathology; Agriculture

Target groups plant science researchers

Type of publication Contributed volume

Due April 2008

2008. Approx. 505 p. 66 illus., 26 in color. Hardcover

99,35 € ISBN 978-0-387-72289-4 springer.com/booksellers Life Science 129

A. Ule, Amsterdam, The Netherlands R. Uppu, Southern University and A&M College; W.A. Pryor, S.N. V.A. Vaclavik, University of Texas, Dallas, TX, USA; E.W. Christian, Murthy (Eds.) Texas Woman’s University, Denton, TX, USA Partner Choice and Cooperation in Networks Free Radicals and Antioxidant Essentials of Food Science Protocols Third Edition Theory and Experimental Evidence

Knowledge of food science is applicable to all per- Cooperation is beneficial but may be hard to achieve Fields of interest sons, in diverse college majors. This text is designed in situations where the selfish interests of individuals Biochemistry, general with a user-friendly approach to Food Science for conflict with their common goal, such as in sharing the non-major. This text reviews an Introduction to of goods, help, knowledge or information, in trade Type of publication Food Components – quality and water. Next it ad- and pollution negotiations, and in exploitation of Contributed volume dresses carbohydrates – including starches, pectins common resources. The standard models of such and gums, breads and pasta, vegetables and fruits. "social dilemmas" assume that the individuals are Due October 2008 Then proteins – meats, poultry, fish, beans, eggs, obliged to participate in the dilemma. These models milk and milk products are presented. Following fail to capture an important element of human inter- proteins are fats and emulsions. Then sugars and action: that people are in general free to select their 2008. (Methods in Molecular Biology, Preliminary entry 2034) Hardcover sweeteners, and baked products, the latter of which interaction partners. In this book a social dilemma builds upon basic food component knowledge. with partner selection is introduced and studied with 89,95 € Various aspects of Food Production are examined, the methods of formal game theory, experimental ISBN 978-1-58829-710-5 including food safety, preservation and pro- economics and computer simulations. It allows ex- cessing, food additives and packaging. Government ploration of simultaneous dynamics of the network regulation and labeling complete the chapter infor- structure and cooperative behavior on this structure. mation. New in this edition are "Culinary Alerts!" The results of this study show that partner choice scattered throughout chapters. Their inclusion allow strongly facilitates cooperation and leads to networks the reader to more easily apply text information to where free-riders are likely to be excluded. cooking applications. Also new are the [..] Fields of interest Features Economic Theory; Behavioural Sciences; Microeco- thorough updates on: food commodities, optimiz- nomics; Game Theory, Economics, Social and Behav. ing quality, laws, and food safety new topics on RFID Sciences; Sociology (Radio frequency ID) tags, and trans fat disclosures Target groups Contents Scientists Preface.- World Wide Web Sites.- Introduction to Type of publication Food Components: Evaluation of Food Quality.- Monograph Water.- Carbohydrates: Carbohydrates in Food – An Introduction.- Starches in Food.- Pectins and Gums.- Grains–Cereal, Flour, Rice, and Pasta.- Vegetables Due January 2008 and Fruits.- Proteins: Proteins in Food – An Intro- duction.- Meat, Poultry, Fish, and Dry Beans.- Eggs 2008. X, 202 p., 29 illus. (Lecture Notes in Economics and Mathe- and Egg Products.- Milk and Milk Products.- Fats: matical Systems, Vol. 598) Softcover Fat and Oil Products.- Sugar, Sweeteners, and Con- fections.- Baked Products: Baked Products, Batters, 64,95 € and Dough.- Aspects of Food Production: Food Safe- ISBN 978-3-540-73015-6 ty.- Food Preservation and Processing.- [..]

Fields of interest Food Science; Nutrition

Target groups Students majoring in Food Science, Nutrition majors studying Food Science in a Nutrition or Dietetics En- vironment, students taking an intro to Food Science class for a science credit

Type of publication Graduate/advanced undergraduate textbook

Due December 2007

2008. Approx. 660 p. 117 illus. (Food Science Texts Series) Soft- cover

52,95 € ISBN 978-0-387-69939-4 130 Life Science springer.com/booksellers

O. Van Auken, The University of Texas, San Antonio, TX, USA (Ed.) F. Van Dyke, Wheaton College, Illinois, USA 2nd edition. Originally published by McGraw Hill, New York, 2002 Western North American Juniperus Conservation Biology, 2nd Edition 2008. Approx. 450 p. Hardcover Communities Foundations, Concepts, Applications 50,00 € A Dynamic Vegetation Type ISBN 978-1-4020-6890-4

Fred van Dyke’s new textbook, Conservation Biol- ogy: Foundations, Concepts, Applications, 2nd Edi- In North America Juniperus woodlands occupy ap- tion, represents a major new text for anyone inter- proximately 55 million hectares, an area larger than ested in conservation. Building on his experience as the state of Texas. Various species of Juniperus have a successful textbook author van Dyke uses his or- been increasing in density and are expanding in- ganizational clarity and readable style to the full to to associated grasslands, reducing the size of the produce this excellent synthesis. The result, which grasslands. The reason for the Juniperus expansion presents key information and well-selected examples, is highly debated, but has important implications will be an invaluable resource for students in conser- for global change and fire regime studies. Western vation around the globe. This student-friendly vol- North American Juniperus Communities address- ume carefully integrates the science of conservation es various aspects of the biology, ecology, and man- biology with its implications for ethics, law, policy agement of Juniperus woodlands and savannas, by and economics in a way which both engages students synthesizing past, current, and proposed future re- and is unique to this book. Moreover, while cover- search. The book will provide professionals with a ing all the theory expected of such a text, the book’s solid background in Juniperus ecosystems, enabling chapters on aquatic conservation and participation, them to manage the communities for maximum sus- as well as its strong emphasis on the purpose of contained productivity and diversity. Although the book servation and implementation of conservation prac- focuses on Juniperus communities in North Ameri- tice, set it apart from other texts. Aimed primarily at ca, a discussion of other regions and larger research undergraduates studying [..] implications is included as well. Features Features A skilfully written, readable style that permits stu- Gathers biological and ecological research together dents to re-create the intellectual process of connect- for use by researchers and managers working with ing empirical studies with conceptual theories and Juniperus ecosystems Discusses application of in- models to reaching conclusions and insights need- cluded research to Juniperus communities through- ed for conservation application and management out the world Presentation of and original insight on the latest de- Contents velopments in conservation theory and application Introduction and overview of Juniperus woodlands.- Strong organizational coherence with logical flow Modern distribution of Juniperus communities.- The and [..] historical distribution and abundance of Juniperus Contents in North America.- The distribution of Juniperus 1. The History and Distinctions of Conservation woodlands in relation to landform.- Structure of Ju- Biology.- 2. Values and Ethics in Conservation.- niperus woodlands.- Canopy/intercanopy patterns in 3. The Legal Foundations of Conservation woodlands: interrelationships between structure and Biology.- 4. Biodiversity: Concept, function.- Comparison of the understory vegetation measurement, and Challenge.- 5. Bio- of Juniperus woodlands.- Ecological consequences of diversity Conservation and Climate Change.-&nb- the displacement of native grassland by Juniperus.- sp;6. Genetic Diversity – Understanding Conser- Changes in nitrogen cycling dynamics following Ju- vation at Genetic Levels.- 7. Genetic niperus encroachment into [..] Management - Managing Genetic Diversity for Fields of interest Conservation Goals.- 8. The Conservaion Ecology; Environmental Management; Plant Ecol- of Populations: Concept, Theory, and Analysis.- ogy; Nature Conservation; Forestry Management; 9. Population Management and Restoration.- 10. Landscape Ecology The Conservation of Habitat [..]

Target groups Fields of interest Ecologists, land managers, forestry professionals Biodiversity; Applied Ecology; Environmental Man- agement; Population Ecology; Landscape Ecology Type of publication Professional book Target groups College and university professors, teaching an advanced undergraduate or beginning gradaute course Due December 2007 in conservation biology and their students, professors and student audiences in courses with titles such 2008. Approx. 400 p. (Ecological Studies, Vol. 196) Hardcover as "Principles of Conservation Biology," "Issues in Conservation Biology" "Principles of Wildlife Ecolo- 129,95 € gy," Wildlife Ecology and Management," "Biological ISBN 978-0-387-34002-9 Conservation," "Wildlife Conservation" "Resource Management," or "Applied Ecology", mainly in the United States and Canada, the United [..]

Type of publication Graduate/advanced undergraduate textbook

Due January 2008 springer.com/booksellers Life Science 131

J.L. VandeBerg, Southwest National Primate Research Center, A. Varma, Amity Institute, Noida, India; L. Abbott, The Universi- R. Varshney, ICRISAT, Patancheru, India; R. Tuberosa, University of San Antonio, TX, USA; S. Williams-Blangero, Southwest Founda- ty of Western Australia, Nedlands, WA, Australia; D. Werner, Uni- Bologna, Italy (Eds.) tion for Biomedical Research, San Antonio, TX, USA; S.D. Tardif, versity of Marburg, Germany; R. Hampp, University of Tübingen, Southwest National Primate Research Center, San Antonio, TX, Germany (Eds.) USA (Eds.) Genomics-Assisted Crop Plant Surface Microbiology Improvement The Baboon in Biomedical Research Vol 1: Genomics Approaches and Platforms

Most plants rely on the co-existence with microor- The present volume was written to provide an ganisms: both groups benefit from these symbios- Genomics research has great potential to revolution- overview of many diverse areas of biomedical re- es. It has been shown that a large number of specif- ize the discipline of plant breeding. This two-vol- search to which the baboon has made and contin- ic genes in plants and microorganisms are only acti- ume set provides a critical assessment of genomics ues to make important contributions. Each chapter vated during these interactions. Of course, various tools and approaches for crop breeding. Volume reviews the recent literature on the topic, discusses microbes also act as pathogens. Interactions between 1, entitled "Genomics Approaches and Platforms", work in progress, and presents the authors’ vision plants and microorganisms are often located on illustrates state-of-the-art genomics approaches of research opportunities and likely future contribu- plant surfaces, such as leaf cuticles, seeds and main- and platforms presently available for crop improve- tions of the baboon model to human medicine. The ly on the roots. The communication between plants ment. Volume 2, entitled "Genomics Applications baboon is a relative newcomer to the repertoire of and microbes is the main topic treated in "Plant Sur- in Crops", compiles crop-specific studies that sum- nonhuman primates used in biomedical research. face Microbiology", such as the signaling within a marize both the achievements and limitations of ge- However, in less than 50 years since its first use in symbiosis, the molecular differences between sym- nomics research for crop improvement. We hope the U.S. it has become one of the most popular lab- biotic and pathogenic microorganisms, the role of that these two volumes, while providing new ideas oratory primate species. It is larger than the other microorganisms in the development of plants or in and opportunities to those working in crop breeding, widely used monkey species, making it advantageous plant protection against deleterious agents. Further will help graduate students and teachers to develop for many types of experiments and technological de- contributions are devoted to: the analysis of bacterial a better understanding of the applications of crop ge- velopments. It is extraordinarily hardy and highly fe- communities in the rhizosphere; microbial popula- nomics to plant research and breeding cund in captivity. It closely resembles humans in a tion genetics; aspects of mycorrhizal symbiosis; func- variety of physiological and disease processes, such tional genomic approaches and the use of microor- Features as cholesterol metabolism, early stages of atheroscle- ganisms as bio-indicator of soil disturbance. A unique collection of review articles on plant ge- rosis, and alcoholic liver disease. Its chromosomes nomics A state-of-the-art presentation of genomics [..] Features applied to crop improvement A bridge to fill the gap Enables researchers to identify which experimental between conventional and modern breeding Features approaches might provide the most realistic evalua- -First volume since 1965 to provide in depth study tion of the roles of microorganisms in natural com- Contents of Baboon in Biomedical Research - Among all pri- munities The highly complex interactions of micro- 1.Genomics-assisted crop improvement: an mates, baboons are the most widely used as models bial communities with plants are illustrated by pre- overview.- 2. Genic molecular markers in for the genetics of susceptibility to complex diseases senting concrete experimental studies of typical sym- plants:development and applications.- 3. Molecular and they are the first nonhuman primate for which biosis breeding: maximizing the exploitation of genetic di- a framework genetic linkage map was established. In versity.- 4. Modeling QTL effects and marker-assist- addition, the baboon genome is currently being se- Contents ed selection in plant breeding.- 5. Applications of quenced, and as a result the utility of this species for The complete table of contents can be found on the linkage disequilibrium and association mapping in [..] internet: springeronline.com crop plants.- 6. Exploitation of natural biodiversity through genomics.- 7. Genomeless genomics in crop Contents Fields of interest improvement.- 8. Comparative genomics of cereals.- Preface.- Introduction.- The Development and Sta- Plant Sciences; Agriculture; Microbial Ecology; Eu- 9. Cloning QTLs in plants.- 10. Use of serial analysis tus of the Baboon Genetic Linkage Map.- The Study karyotic Microbiology; Plant Pathology; Plant Physi- of gene expression (SAGE) for transcript [..] of Captive Baboon Behavior.- Microbiology of Cap- ology tive Baboons.- Spontaneous Pathology of Baboons.- Fields of interest Target groups Growth and Development of Baboons.- Reproduc- Plant Sciences; Plant Genetics & Genomics; Agricul- Scientists in microbiology and plant sciences tive Biology of Baboons.- Baboon Model for En- ture; Biotechnology dometriosis.- The Baboon in Embryology and Ter- Type of publication atology Research .- Baboon Models for Neonatal Target groups Monograph Lung Disease.- The Baboon Model for Dental De- Genomics specialists, geneticists, plant breeders, velopment.- Baboon Model for Dyslipidemia and crop physiologists, teachers, graduate and under- Atherosclerosis.- Baboon Model for the Study of Nu- Due October 2007 graduate students; university and research institute tritional Influences on Pregnancy.- Baboon Model libraries for Infant Nutrition.- [..] 2008. XXXI, 628 p. 138 illus., 2 in color. Softcover Type of publication Fields of interest 69,95 € Contributed volume Anthropology; Zoology ISBN 978-3-540-74050-6 Due October 2007 Target groups Researchers, Scientists, Professionals, and Graduate students in the fields of Primatology, Physical An- 2007. XXIV, 388 p. Hardcover thropology, Zoology and Animal Behavior 154,95 € Type of publication ISBN 978-1-4020-6294-0 Contributed volume

Due July 2008

2008. (Developments in Primatology: Progress and Prospects) Hardcover

99,35 € ISBN 978-0-387-75990-6 132 Life Science springer.com/booksellers

R. Varshney, ICRISAT, Patancheru, India; R. Tuberosa, University of S.C. Veasey, University of Pennsylvania School of Medicine, D.P.S. Verma, The Ohio State University, Columbus, OH, USA; Z. Bologna, Italy (Eds.) Philadelphia, PA, USA (Ed.) Hong, University of Idaho, Moscow, ID, USA (Eds.)

Genomics-Assisted Crop Oxidative Neural Injury Cell Division Control in Plants Improvement

Vol 2: Genomics Applications in Crops This book examines the current evidence and re- The molecular mechanisms controlling cell cycle search supporting the importance of oxidative in- progression are highly conserved in eukaryotes. In jury in selected animal models of both neurodegen- addition to the basic protein machinery involved in Genomics research has great potential to revolution- erative diseases and neural injury. Each chapter dis- cell cycle regulation, higher plants have also evolved ize the discipline of plant breeding. This two-vol- cusses oxidative injury in a selected model, analyz- unique molecular mechanisms that allow integration ume set provides a critical assessment of genomics ing the major cellular mechanisms that underpin of environmental, physiological, and developmental tools and approaches for crop breeding. Volume the progression of neural injury. In addition to the signals into networks to control proper cell division 1, entitled "Genomics Approaches and Platforms", analysis of these models, each chapter’s purpose is and expansion. Rapid and exciting research progress illustrates state-of-the-art genomics approaches to not only relate, but to also contrast the specific in- in these fields has been achieved from experimen- and platforms presently available for crop improve- jury across models as a way of identifying the com- tal observations on plants over the past decade. The ment. Volume 2, entitled "Genomics Applications mon and unique pathways of oxidative neural injury. scope of this volume is focused on the molecular ba- in Crops", compiles crop-specific studies that sum- Through this, each author presents possible fertile sis of all aspects of cell division and cytokinesis in marize both the achievements and limitations of ge- future directions for translational research for the plants. It is an essential reference book for instruc- nomics research for crop improvement. We hope identification of possible therapeutics. tors and scientists working in the areas of molecu- that these two volumes, while providing new ideas lar, cell, and developmental biology of plants. The and opportunities to those working in crop breeding, Contents editors of this book are veterans in the field of plant will help graduate students and teachers to develop Basic Redox (reactive oxygen/nitrogen species) Bio- molecular biology and highly respected worldwide. a better understanding of the applications of crop ge- chemistry.- Areas of neuronal loss in hypoixa/re- nomics to plant research and breeding oxygenation oxidative injury.- How oxidative in- Features jury translates into unfolded protein response-in- Covers the molecular mechanisms controling all ma- Features duced cellular dysfunction.- Mitochondrial injury jor aspects of cell division and cytokinesis in plants A unique collection of review articles on plant ge- as a source of oxidative injury to neurons in amy- 19 chapters contributed by world experts in the spe- nomics A state-of-the-art presentation of genomics otrophic lateral sclerosis.- Oxidative injury to the au- cific research fields provide the most comprehensive applied to crop improvement A bridge to fill the gap tonomic nervous system.- Excitatory neurotoxicity and updated knowledge on cell division control in between conventional and modern breeding and ER stress component (Therapeutics part).- Exci- plants Serves as an essential reference source for sci- tatory neurotoxicity and ER stress component (Ther- entists and researchers working in the field of molec- Contents apeutics part).- ROS and brain injury in alzheimer’s.- ular, cell and developmental biology of plants 1. Microsatellite and SNP markers in wheat breed- Oxidative neural injury in Parkinson’s.- [..] ing.- 2. Molecular markers and QTL analysis for Fields of interest grain quality improvement in wheat.- 3. Molecular Fields of interest Plant Sciences; Plant Physiology; Plant Anatomy/De- approaches and breeding strategies for drought toler- Neurosciences; Biochemistry, general; Neurobiology; velopment; Plant Genetics & Genomics ance in barley.- 4. Molecular markers for gene pyra- Human Physiology; Neurology miding and disease resistance breeding in barley.- 5. Target groups Cloning genes and QTLs for disease resistance in ce- Target groups Libraries, institutes, scientists reals.- 6. Maize breeding and genomics.- 7. Molecu- Clinical neuroscientists, neurologists, neuropyschol- lar markers and marker-assisted selection in rice.- 8. ogists, neuro pharmaceutical developers Type of publication Application of genomics for molecular breeding in Contributed volume rice.- 9. Marker-assisted selection in sorghum.- 10. Type of publication Molecular genetics and breeding [..] Contributed volume Due November 2007

Fields of interest Due March 2009 2008. Approx. 370 p. 59 illus. 18 in color (Plant Cell Monographs, Plant Sciences; Plant Genetics & Genomics; Agricul- Vol. 9) Hardcover ture; Biotechnology 2009. Approx. 400 p (Contemporary Clinical Neuroscience) Hard- cover 159,95 € Target groups ISBN 978-3-540-73486-4 Genomics specialists, geneticists, plant breeders, 122,45 € crop physiologists, teachers, graduate and under- ISBN 978-1-60327-341-1 graduate students; university and research institute libraries

Type of publication Contributed volume

Due October 2007

2007. XIV, 498 p. Hardcover

174,95 € ISBN 978-1-4020-6296-4 springer.com/booksellers Life Science 133

E. Vincan, University of Melbourne, Parkville, Victoria, Australia C. Vinyard, Northeastern Ohio University College of Medicine, A. Vlahou, Foundation for Biomedical Research, Athens, Greece (Ed.) Rootstown, OH, USA; M.J. Ravosa, Northwestern University, (Ed.) Chicago, IL, USA; C.E. Wall, Duke University Medical Center, Durham, NC, USA (Eds.) Wnt Signalling Clinical Proteomics

Primate Craniofacial Function and Methods and Protocols Biology Fields of interest Cell Biology The field of clinical proteomics has rapidly evolved during the past few years and is continuously Primate Craniofacial Function and Biology Type of publication growing as new methodologies and technologies is an integrative volume with broad cov- Contributed volume emerge. In Clinical Proteomics, a select group erage of current research on primate craniofacial of leading researchers has contributed their biology and function. Topic headings in- state-of-the-art methodologies on protein profiling Due August 2008 clude: the mammalian perspective on primate cran- and identification of disease biomarkers in tissues, iofacial form and function, allometric and com- microdissected cells and body fluids. Experimen- parative morphological studies of primate heads, 2008. Approx. 300 p. (Methods in Molecular Biology, Preliminary tal approaches involving the application of two-di- entry 2158) Hardcover in vivo research on primate mastication, model- mensional electrophoresis, multi-dimensional liquid ing of the primate masticatory apparatus, primate chromatography, SELDI/MALDI mass spectrome- 76,65 € dental form and function, and palaeoanthropo- try and protein arrays, as well as the bioinformatic ISBN 978-1-58829-912-3 logic studies of primate skulls. Additionally, the and statistical tools pertinent to the analysis of pro- volume includes introductory chapters dis- teomics data, are thoroughly detailed in these read- cussing how primatologists study adapta- ily reproducible methods and protocols, explained tions in primates and a discussion of in vivo ap- through the step-by-step instructional format proaches for studying primate performance. All of the highly successful Methods in Molecular Biolo- chapters are written by experts currently do- gy™ series. ing research in fields ranging from developmental biology and genetics to the study of primate diets in Features remote areas of the world. At present, there are no Step-by-step instructions that ensure successful re- texts with a similar focus on primate craniofacial bi- sults Integrates biochemistry, pathology, analytical ology and no sources that approach this topic from technology, bioinformatics, and proteome informat- such [..] ics

Fields of interest Contents Evolutionary Biology; Animal Anatomy / Morphol- Overview and Introduction to Clinical Proteomics.- ogy / Histology; Animal Physiology; Developmental Specimen collection and handling: Standardization Biology; Anthropology of blood sample collection.- Tissue Sample Collec- tion for Proteomics Analysis.- Protein profiling of Target groups Human Plasma Samples by Two-Dimensional Elec- Researchers, teachers, graduate students and ad- trophoresis.- Analysis of Laser Capture Microdis- vanced undergraduate students working and study- sected Cells by 2-Dimensional Gel Electrophoresis.- ing in the fields of biological and physical anthropol- Optimizing the Difference Gel Electrophoresis (DI- ogy, primatology and mammalogy. GE) technology.- MALDI/SELDI protein profiling of Type of publication serum for the identification of cancer biomarkers.- Contributed volume Urine sample preparation and protein profiling by two-dimensional electrophoresis and matrix [..]

Due July 2008 Fields of interest Proteomics; Cell Biology; Biochemistry, general; 2008. (Developments in Primatology: Progress and Prospects) Bioinformatics Hardcover Target groups ISBN 978-0-387-76584-6 Clinicians, molecular biologists, chemists, bioinformaticians, and computational biologists

Type of publication Contributed volume

Due April 2008

2008. Approx. 480 p. 74 illus. (Methods in Molecular Biology, Vol. 428) Hardcover

76,65 € ISBN 978-1-58829-837-9 134 Life Science springer.com/booksellers

I.N. Vogiatzakis, University of Reading, UK; G. Pungetti, University 125,00 € F. Vonta, University of Cyprus, Nicosia, Cyprus; M. Nikulin, Uni- of Reading, UK; A.M. Mannion, University of Reading, UK (Eds.) ISBN 978-1-4020-5063-3 versité Victor Segalen Bordeaux 2, Bordeaux, France; N. Limnios, Université de Technologie de Compiègne, Compiègne, France; C. Huber-Carol, Université Paris V, Paris, France (Eds.) Mediterranean Island Landscapes

Natural and Cultural Approaches Statistical Models and Methods for Biomedical and Technical Systems

Mediterranean islands exhibit many similarities in their biotic ecological, physical and environmental An outgrowth of the "International Confer- characteristics. There are also many differences in ence on Statistical Models for Biomedical and Tech- terms of their human colonization and current an- nical Systems," this book is comprised of contribu- thropogenic pressures. This book addresses in three tions from renowned experts, demonstrating the sections these characteristics and examines the major significance of current research on theory, meth- environmental changes that the islands experienced ods, and applications of the field. The contributions, during the Quaternary period. The first section pro- which deal with the mathematical aspects of survival vides details on natural and cultural factors which analysis and reliability as well as other topics, are a have shaped island landscapes. It describes the en- careful selection of invited and contributed chapters, vironmental and cultural changes of the Holocene reflecting recent developments in the following ar- and their effects on biota, as well as on the current eas: applications in epidemiology; probabilistic and human pressures that are now threats to the sustain- statistical models and methods in reliability; models ability of the island communities. The second sec- and methods in survival analysis, longevity, aging, tion focuses on the landscapes of the largest islands and degradation; accelerated life models; quality of namely Sicily, Sardinia, Corsica, Cyprus, Crete, Mal- life; new statistical challenges in genomics. The book ta and the Balearics. Each island chapter includes a will be useful to a broad interdisciplinary readership special topic reflecting a particular characteristic of of researchers and practitioners in applied probabil- the island. Part three presents strategies for action to- ity and statistics, industrial statistics, biomedicine, wards sustainability in [..] biostatistics, and engineering. Features Features Only book dealing with Mediterranean island land- Real-world applications to epidemiology, aging, sur- scapes Written by Mediterranean islands experts, vival analysis, and modeling in the biosciences and thus offering first hand knowledge of theory and medicine Chapters deal primarily with the mathe- practice Multidisciplinary effort that encompasses matical aspects of survival analysis and reliability an holistic natural and cultural approach Incorpora- Features a careful selection of invited and contribut- tion of the socio-political components of landscape ed papers Demonstrates the significance of current dynamics Bibliographies to provide general and spe- research on the theory, methods, and applications of cialised further reading Up to date information on the field Accessible to a broad interdisciplinary [..] [..] Contents Contents Preface.- Cox Models, Analyses, and Extensions.- About the contributors. Preface. Acknowledge- Reliability Theory: Degradation Models.- Inferen- ments. Section I: Nature and culture in Mediter- tial Analysis.- Analysis of Censored Data.- Quality of ranean islands. 1. Introduction to Mediterranean is- Life.- Inference for Processes.- Designs.- Measures of land landscapes.- 2. Tertiary-quaternary envi- Divergence, Model Selection, and Survival Models.- ronmental history of the Mediterranean basin.-&nb- New Statistical Challenges.- Index. sp;3. Holocene history of Mediterranean islands. 4. Mediterranean islands: Biogeography and landscape Fields of interest ecology.- 5. Cultural landscapes of Mediter- Statistics for Life Sciences, Medicine, Health Sci- ranean islands.- 6. Political landscapes of Mediter- ences; Statistical Theory and Methods; Mathemati- ranean islands.- Section II: Mediterranean island cal Modeling and Industrial Mathematics; Probabili- landscapes. 7. Sicily.- 8. Sardinia.- 9. Cyprus.-&nb- ty Theory and Stochastic Processes; Applications of sp;10. Corsica.- 11. Crete.- 12. Balearic [..] Mathematics

Fields of interest Target groups Landscape Ecology; Geography; Environment, gen- researchers and practitioners in applied probability eral; Cultural Heritage; Nature Conservation and statistics, industrial statistics, biomedicine, biostatistics, and engineering Target groups Undergraduate and postgraduate students in Type of publication Mediterranean, Europe and other island regions par- Contributed volume ticularly of mediterranean-type climate (i.e. Chile, California, South Africa, Southwest Australia), researchers and university lecturers in ecology, biolo- Due March 2008 gy, nature conservation, geography, planning, poli- cymakers, as well as naturalists, ecotourists and the 2008. Approx. 600 p. 55 illus. (Statistics for Industry and Technol- wider public visiting these popular holiday destina- ogy) Hardcover tions 109,00 € Type of publication ISBN 978-0-8176-4464-2 Contributed volume

Due October 2007

2007. Approx. 300 p. (Landscape Series, Vol. 9) Hardcover springer.com/booksellers Life Science 135

M.J.B. Vreysen, Joint FAO/IAEA Programme of Nuclear Tech- S. Vukicevic, University of Zagreb, Zagreb, Croatia; K.T. Sampath, M.R. Wagner, School of Forestry, Northern Arizona University, niques in Food and Agriculture, Vienna, Austria; A.S. Robinson, Genzyme Corporation, Framingham, USA (Eds.) Flagstaff, USA; J.R. Cobbinah, P.P. Bosu Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria; J. Hendrichs, Joint FAO/IAEA Pro- gramme of Nuclear Techniques in Food and Agriculture, Vienna, Bone Morphogenetic Proteins: Forest Entomology in West Tropical Austria (Eds.) From Local to Systemic Africa: Forest Insects of Ghana Area-Wide Control of Insect Pests Therapeutics

From Research to Field Implementation The forests of West Africa are complex, beautiful and under continued threat of over exploitation. This Tissue engineering is gaining interest as it is applied monograph, in its second edition, remains the only for regeneration of organs to attain their lost func- comprehensive source of information on economi- "If major advances are to be made in coping with tion. BMPs have been successfully used to regener- cally important forest insects in West Africa. Many most of the major arthropod pest problems, then ate the bone in humans. Most recent preclinical da- pest insects discussed in this book have the poten- the tactics and strategies for managing such insects, ta suggest that BMPs have a potential to provide pro- tial to greatly alter the utilization of these valuable ticks and mites must change. They must change from tection against inflammation and fibrosis in acute tropical forests. Several key pests such as mahogany the current, limited scale, reactive, broad-spectrum and chronic injury of parenchymal tissues when ap- shoot borer, odum gall fly and pests of endangered measures to preventive measures that are target-pest plied systemically to sustain the function of kidney tree species like Pericopsis, are extensively discussed. specific and rigidly applied on an area-wide basis." and liver. The application of BMPs from a local to This comprehensive treatise of insects includes infor- E.F. Knipling on the occasion of receiving the World systemic utility is a rapidly growing field, gaining in- mation on the general forest cover types and insects Food Prize on 12 October 1992. terest among researchers and biotech entrepreneurs. of utilitarian value. The book will be a great value to In this volume, we summarize the advances made on foresters, forest entomologists, researchers, conser- Features the local and systemic use of BMPs including chap- vation biologists and others with a basic biological This new textbook collates a series of selected papers ters covering the regulation of BMP-signalling path- interest in West Africa forests. that attempts to address various fundamental com- ways, biological actions of BMPs in bone, cartilage ponents of AW-IPM Of special interest are the nu- and teeth, as well as clinical applications and poten- Features merous papers on pilot and operational programmes tial systemic use of BMPs for tissues beyond bone. Complete upgrade to all photos, figures, tables, line that pay special attention to practical problems en- drawings, etc. to improve clarity Update of all avail- countered during programme implementation A Features able literature covering the topics in the book Addi- compilation of 66 papers that are authored by ex- Completes the series of PIR-volumes on BMPs by tion of a new chapter on forest invasive insect pests perts from more than 30 countries S. Vukicevic/K.T. Sampath with most recent data and the international timber trade as related to West (Bone Morphogenetic Proteins - Regeneration of Africa Addition of a comprehensive appendix/index Contents Bone and Beyond / 2004; and Bone Morphogenet- that lists all forest insect species and their host asso- From the contents Preface. Disclaimer. Introductory ic Proteins - From Laboratory to Clinical Practice / ciation in Ghana Remarks. Section 1. Setting the Scene. Section 2. Ba- 2002) Written by experts in the field sic Research. Section 3. Modelling and Methods De- Fields of interest velopment. Section 4. Feasibility Studies. Section 5. Contents Invertebrates; Forestry; Forestry Management; Zool- Commercialization and Regulation. Section 6. Pilot From the contents: An update on BMP biology.- ogy; Animal Systematics/Taxonomy/Biogeography Programmes. Section 7. Operational AW-IPM Pro- Regulation of BMP-2 and GDF5 signaling by lig- grammes. Section 8. Lessons Learned. Author Index. and mutants and receptor endocytosis.- Signal- Target groups Subject Index. ing crosstalk.- Generation of conditional alleles for Foresters, forest entomologists, researchers, conser- BMP-2 and BMP-7.- BMP-2 and BMP-4 action in vation biologists and others with basic biological in- Fields of interest bone.- Role of BMP-4 in tooth differentiation and terest in West Africa forests. Invertebrates; Agriculture; Zoology bone morphogenesis.- Alterations of BMP signaling pathway(s) in skeletal malformations.- BMP antago- Type of publication Target groups nists and kidney.- SOST related biology.- BMP-7 in- Monograph Libraries, practitioners/professionals, scientists/reduced tumor-stroma interactions in bone metasta- searchers, lecturers/tutors, graduate and undergrad- sis.- Endocultivation of vascularized bone segments.- Due October 2007 uate students. Induction of cementogenesis and periodontal tissue [..] Type of publication 2007. Approx. 230 p. Hardcover Proceedings Fields of interest Biotechnology; Immunology; Rheumatology; Ortho- 130,00 € Due October 2007 pedics; Cell Biology ISBN 978-1-4020-6506-4

Target groups 2007. Approx. 800 p. Hardcover Scientific libraries; researchers from immunology, 189,95 € cell biology, biochemistry, and clinicians from or- ISBN 978-1-4020-6058-8 thopedics and dentistry; research managers from biotech and pharmaceutical companies

Type of publication Monograph

Due March 2008

2008. Approx. 300 p. (Progress in Inflammation Research) Hard- cover

119,00 € ISBN 978-3-7643-8551-4 136 Life Science springer.com/booksellers

J.M. Walker, University of Hertfordshire, Hatfield, Herts, UK; R. J.M. Walker, University of Hertfordshire, Hatfield, Herts, UK; R. L. Wang, Beijing University of Post and Telecom, Beijing, China; Rapley, University of Hertfordshire, Hatfield, Herts, UK (Eds.) Rapley, University of Hertfordshire, Hatfield, Herts, UK (Eds.) W. Stefan, Ruprecht-Karls-Universität Heidelberg, Germany; M. Jiang, Tsinghua University, Beijing, China Molecular Biomethods Handbook Molecular Biomethods Handbook New Antibody Microarray Tube for Cellular Localization and Signaling Recent advances in the biosciences have led to a Recent advances in the biosciences have led to a Pathways range of powerful new technologies, particularly nu- range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The cleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scien- most recent insights have come to affect how scientists investigate and define cellular processes at the tists investigate and define cellular processes at the The subject of this book is a new antibody microar- molecular level. Molecular Biomethods Handbook, molecular level. Molecular Biomethods Handbook, ray tube for cellular localization and signaling path- 2nd Edition expands upon the techniques includ- 2nd Edition expands upon the techniques includ- ways. With the post-genome era, proteomics study ed in the first edition, providing theory, outlines of ed in the first edition, providing theory, outlines of for direct analysis of a group of proteins by biochip practical procedures, and applications for a range of practical procedures, and applications for a range of becomes more and more important. Identification techniques. Part A of the book describes nucleic acid techniques. Part A of the book describes nucleic acid of its location often provides crucial information for methods, such as gene expression profiling, microar- methods, such as gene expression profiling, microar- understanding the function or regulation of a given ray analysis and quantitative PCR. In Part B, pro- ray analysis and quantitative PCR. In Part B, pro- protein in biological pathways. One new biochip, the tein and cell-based methods are outlined, in subjects tein and cell-based methods are outlined, in subjects antibody microarray tube was developed with cellu- ranging from protein engineering to high through- ranging from protein engineering to high through- lar localization and bioinformatics technologies input screening. Written by a well-established panel put screening. Written by a well-established panel corporated into it, for setting-up signaling pathways of research scientists, Molecular Biomethods Hand- of research scientists, Molecular Biomethods Hand- and making new discoveries. With this book and its book, 2nd Edition provides an up to date collection book, 2nd Edition provides an up-to-date collection 50 tables and figures, the reader can not only learn of methods used regularly in the authors’ own re- of methods used regularly in the authors’ own re- about new technologies but also about cellular lo- search programs. This book will prove to be an in- search programs. This book will prove to be an in- calization, signaling pathways, and protein relation- valuable reference for those engaged in or [..] valuable reference for those engaged in or [..] ships.

Features Features Features - Comprehensive collection of wide-ranging molec- - Comprehensive collection of wide ranging molec- Introduces a new biochip that incorporates cellu- ular and biochemical techniques frequently used in ular and biochemical techniques frequently used in lar localization and bioinformatics technologies De- medical and clinical research laboratories around the medical and clinical research laboratories around the scribes signaling pathways, and protein relationships world. - Covers a wide array of techniques and pro- world. - Covers a wide array of techniques and pro- Contents tocols used for diagnostics. - Includes step-by-step tocols used for diagnostics. - Includes step-by-step 1. Introduction.- 2. Technologies.- 3. New cytoplas- reproducible laboratory protocols written by experts reproducible laboratory protocols written by experts mic and nuclear BMP2- Signalling pattern In U937 in the field and includes a notes section that outlines in the field and includes a notes section that outlines Cells.- 4. New cytoplasmic and nuclear BMP2- Sig- tricks of the trade. - Provides in-depth [..] tricks of the trade. - Provides in-depth [..] nalling In MCF7 Cells.- 5. New cytoplasmic and nu- Contents Contents clear STI Signalling In K562 Cells.- 6. cytoplasmic PART A: NUCLEIC ACID BIOMETHODS The PART A: NUCLEIC ACID BIOMETHODS signaling in chosen functions of three treated cell manipulation of nucleic acids: basic tools and tech- The manipulation of nucleic acids: basic tools and lines.- 7. Proteomic Silencing in Treated Human niques.- Restriction Enzymes.- Principles techniques.- Restriction Enzymes.- Princi- Cancer Cell Lines.- 8. Signaling pathway setting-up and Medical Applications of the Polymerase Chain ples and Medical Applications of the Polymerase based on bioinformatics. Reaction.- Probe Design, Production, and Chain Reaction.- Probe Design, Production, Fields of interest Applications.- Southern Blotting as a Di- and Applications.- Southern Blotting as a Biomedical Engineering; Proteomics; Bioinformatics agnostic Method.- Introduction to Capil- Diagnostic Method.- Introduction to Cap- lary Electrophoresis of DNA.- Denaturing illary Electrophoresis of DNA.- Denaturing Target groups High-Performance Liquid Chromatography (DH- High-Performance Liquid Chromatography (DH- Postgraduates, and professionals in electronic engi- PLC) for nucleic acid analysis.- Denaturing PLC) for nucleic acid analysis.- Denaturing neering, biochemistry, cell biology, molecular biolo- Gradient Gel Electrophoresis (DGGE).- Single Gradient Gel Electrophoresis (DGGE).- Single gy, pharmacy studies Strand Conformation Polymorphism (SSCP) Analy- Strand Conformation Polymorphism (SSCP) Analy- sis.- Randomly amplified polymorphic DNA sis.- Randomly amplified [..] Type of publication [..] Monograph Fields of interest Fields of interest Biochemistry, general; Molecular Medicine; Human Biochemistry, general; Molecular Medicine; Human Genetics; Laboratory Medicine; Cell Biology Due February 2008 Genetics; Laboratory Medicine; Cell Biology Target groups No distribution rights in mainland China Target groups Molecular biologists, graduate students, undergradu- Molecular biologists, graduate students, undergraduate students, research scientists, technicians Co-published with Tsinghua University Press ate students, research scientists, technicians Type of publication Type of publication Contributed volume 2008. Approx. 160 p. Hardcover Contributed volume 139,00 € Due June 2008 ISBN 978-3-540-74340-8 Due June 2008 2008. Approx. 1100 p. 296 illus. Softcover 2008. Approx. 1100 p. 296 illus. Hardcover 83,95 € 88,55 € ISBN 978-1-60327-374-9 ISBN 978-1-60327-370-1 springer.com/booksellers Life Science 137

A. Ward, University of Bath (Ed.) G. Ware, Tucson, AZ, USA (Ed.) R. Waynant, Food and Drug Administration, Silver Spring, MD, USA; D.B. Tata, Food and Drug Administration, Silver Spring, MD, USA (Eds.) Mouse Cell Culture Proceedings of Light-Activated Features Tissue Regeneration and Therapy II Publishes detailed scientific review articles on all as- Fields of interest pects of environmental contamination and associat- Conference Cell Biology ed toxicological consequences Facilitates the task of Type of publication accessing and interpreting cogent scientific data Of Contributed volume interest to researchers, resource managers, and poli- Proceedings of the Light-Activated Tissue Regen- cy administrators eration and Therapy II Conference covers issues Due October 2008 such as the latest advances in the field and measure- Contents ments including the determination of the mecha- Foreword.- Preface.- Polycyclic Aromatic Hydro- nisms of light-activated tissue regeneration and ther- 2008. 300 p. (Methods in Molecular Biology, Preliminary entry carbons (PAHs) from Coal Combustion: Emis- apy. Light sources, narrow and broadband, as well as 2100) Hardcover sions, Analysis, and Toxicology.- Pasture Soils Con- the metrology and medical outcomes they produce, taminated with Fertilizer-Derived Cadmium and will be discussed. This book discusses the following 74,95 € Flourine: Livestock Effects.- Aquatic Plants Exposed ISBN 978-1-58829-772-3 topics: Laser therapy; Mechanism; Photodynamic to Pharmaceuticals: Effects and Risks.- Risk of Wa- therapy; Cardiovascular; Pain; Neuroscience/Pro- terborne Illness via Drinking Water in the Unit- genitor and Stem cells; Wound healing; Unusual ed States.- Biological Removal of Nitrogen from Sources; Electrical Fields, Optical Fields and Other Wastewater.- Index. fields; Dentistry; Diabetes. This book is the first to present the mechanism which explains why light is Fields of interest an effective treatment for so many illnesses and dis- Applied Ecology; Industrial Pollution Prevention; eases. Proceedings of the Light-Activated Tissue Re- Soil Science & Conservation; Monitoring/Environ- generation and Therapy II Conference not only ex- mental Analysis/Environmental Ecotoxicology; Ter- plains this mechanism, but also describes uses for the restrial Pollution; Waste Water Technology / Water mechanism, as well as what new work is planned and Pollution Control / Water Management / Aquatic what changes will be seen in FDA regulations. Pollution Features Target groups First book to present the mechanism explaining why Researchers, industry scientists light is effective in the treatment of so many illnesses Type of publication and diseases Offers a systematic approach to the field Professional book of Light-Activated Tissue Regeneration and Therapy covering theory, basic research, clinical studies and therapies Includes extensive papers and coverage on Due November 2007 such interesting topics as: pain, wound healing, diabetes, cardiovascular and stroke repair, [..] 2008. Approx. 200 p. (Reviews of Environmental Contamination and Toxicology, Vol. 192) Hardcover Contents Laser therapy. General mechanism. Enzyme absorp- 84,95 € tion. Cell response.- Mechanism. Drug production. ISBN 978-0-387-71723-4 Cell growth. Inhibition. Systemic Effect. Inhibition of Cancer Growth. High dose stimulation. Data/con- firmation of mechanism. Potential areas of health benefits - cancer, cardiovascular, diabetes.- Photody- namic therapy. How it differs from laser therapy. Use as cancer treatment. Mechanism. Macular degenera- tion therapy.- Cardiovascular. Reduction of damage from Heart Attack. Treatment of Stroke. Clearing of plaque from arteries. Preliminary studies.- Pain. Treatment of chronic pain.- [..]

Fields of interest Biomedical Engineering; Biophysics; Laser Technol- ogy and Physics, Photonics; Biomedicine general

Target groups Optical engineers, biomedical researchers, and others interested in the latest state of the art research in the area of Light-Activated Tissue Regeneration and Therapy

Type of publication Monograph

Due April 2008

2008. Approx. 400 p. (Lecture Notes Electrical Engineering, Pre- liminary entry 15) Hardcover

99,95 € ISBN 978-0-387-71808-8 138 Life Science springer.com/booksellers

J.F. Webb, Villanova University, Villanova, PA, USA; R.R. Fay, Loy- G.W. Weber, Universität Wien; F.L. Bookstein, Universität Wien M. Weidenbörner, Bonn, Germany ola University of Chicago, IL, USA; A.N. Popper, University of Maryland, College Park, MD, USA (Eds.) Virtual Anthropology Mycotoxins in Foodstuff

Fish Bioacoustics A guide to a new interdisciplinary field

Due to the serious spoilage and health issues the presence of mycotoxins can cause, it’s imperative This first textbook for "Virtual Anthropology", a new The study of how fish make and respond to sound that the food industry has a basic understanding fun- branch of science that combines elements from such has important implications for communication, gi and their corresponding mycotoxins. An indis- different fields as anthropology, radiology, foren- physiology, behavior, and commercial techniques. pensable resource, Mycotoxins in Foodstuff sics, mathematics, and computer science, is intend- This new definitive volume on fish auditory systems gives an in depth overview by listing the degree of ed to be used by all kinds of students from biologi- will interest investigators in both basic research of contamination, concentration and country of ori- cal to medical and technical fields as well as by teach- fish bioacoustics as well as investigators in applied gin/detection for each case of mycotoxin contami- ers, journalists, and interested laymen. The contents aspects of fisheries and resource management. Top- nation for each commodity. In addition, the book spans from an introduction into the discipline over ics will cover structure, physiology, localization, and shows whether or not food is predisposed for myco- medical imaging and digitising techniques, the anal- acoustic behavior as well as more applied topics such toxin contamination. as using sound to detect and locate fish. ysis and reconstruction of morphology based on spatial geometry of biological objects, to many exam- Features Features ples of real applications and future perspectives for The first complete reference covering relevant toxin Explores fish bioacoustics both from a basic perspec- researchers. Readers are not stressed with a flood of producing fungi in foodstuff tive of understanding how fishes detect and process technical details but rather introduced step by step signals, and from an applied perspective showing into the methods of operation to particularly under- Fields of interest how bioacoustics is used to understand and affect stand their relevance for research and society. Read- Food Science; Analytical Chemistry; Microbiology fish behavior ers are likewise encouraged to have a go on their own using the enclosed DVD that contains instruc- Target groups Contents tive exercises, answers, links to free software, and 2D Professionals in the food industry, agriculture, con- Introduction to Fish Bioacoustics.- Hearing and & 3D data to make the [..] trol agencies, those involved in food processing, food Acoustic Behavior (Basic and Applied).- Structures chemistry, and microbiology, mycologists and myco- and Functions of the Auditory Nervous System of Features toxicologists Fishes.- Evolution of Peripheral Mechanisms for the new and unique textbook to a new branch of science Enhancement of Sound Reception.- Bioacoustics and interdisciplinary approach DVD with instructive ex- Type of publication the Lateral Line of Fishes.- Orientation to Auditory ercises Reference work and Lateral Line Stimuli.- Multipole Mechanisms for Directional Hearing in Fish.- Vocal-Acoustic Com- Fields of interest Due December 2007 munication: From Neurons to Behavior.- Active and Anthropology; Evolutionary Biology; Computer Ap- Passive Acoustics to Locate and Study Fish. pl. in Life Sciences; Archaeology; Life Sciences, general; Applications of Mathematics 2008. Approx. 997 p. Hardcover Fields of interest 153,25 € Animal Physiology; Applied Ecology; Neurobiology; Target groups ISBN 978-0-387-73688-4 Biophysics Students form biological, medical and technical fields, Teachers, Journalists, Interested Laymen Target groups Researchers, graduate students, practitioners-fish- Type of publication eries Atlas

Type of publication Due December 2007 Monograph

2008. Approx. 250 p. 250 illus., 100 in color. Hardcover Due March 2008 49,90 € 2008. Approx. 350 p. (Springer Handbook of Auditory Research, ISBN 978-3-211-48647-4 Vol. 32) Hardcover

99,35 € ISBN 978-0-387-73028-8 springer.com/booksellers Life Science 139

L.P. Weiner, Keck School of Medicine of the University of South- W.W. Weisser, University of Jena, Germany; E. Siemann, Rice Uni- ern California, Los Angeles, CA, USA (Ed.) versity, Houston, TX, USA (Eds.)

Neural Stem Cells Insects and Ecosystem Function

Methods and Protocols

In the past two decades, an increasing number of ecologists have started to investigate the importance Although there has been an explosion of interest and of biodiversity for ecological processes such as en- technology in the study of neural stem cells, many ergy flow and nutrient cycling, often referred to as questions related to stem cell properties and neural 'ecosystem functioning'. Insects are a dominant com- stem cell lineage and differentiation still linger. Neu- ponent of biodiversity in terrestrial ecosystems and ral Stem Cells, 2nd Edition revises and expands up- play a key role in mediating the relationship between on the successful first edition in order to provide the plants and ecosystem processes. This volume is the most current, cutting-edge methods of today for the first to summarize their effects on ecosystem func- scientists working to answer these questions. The use tioning, focusing mainly, but not exclusively, on her- of these step-by-step, readily reproducible laborato- bivorous insects. Renowned authors with extensive ry protocols will allow investigators to produce pure experience in the field of plant-insect interactions, populations that can serve as a means of understand- contribute to the volume using examples from their ing the biology of neural stem cells and adapting own work. In addition to providing concise reviews them for transplantation into disease models. Fol- of the field, this volume discusses in detail the advan- lowing the Methods in Molecular Biology™ series for- tages and disadvantages of various techniques of ma- mat, each chapter has an extended introduction for nipulating insect herbivory. Thus, the text provides background, a list of necessary materials, and tips on both a theoretical basis as well as practical advice for troubleshooting and avoiding known pitfalls. Com- future manipulative studies of biodiversity-ecosys- prehensive and current, Neural Stem Cells, 2nd Edi- tem functioning. tion is an excellent source of information and inspiration for scientists [..] Contents Various effects of insects on ecosystem function- Features ing.- Insect herbivores, nutrient cycling and plant Focus on clinical and translational relevance New productivity.- Indirect effects of invertebrate her- and revised chapters that include neural stem cell bivory on the decomposer subsystem.- Biotic inter- markers, cytogenetics, and polymerase chain reac- actions in the rhizosphere.- Below-ground herbi- tions, among others vores and ecosystem processes.- Bottom-up effects Contents and feed-backs in simple and diverse experimen- Definitions and Criteria for Stem Cells.- Neural Stem tal grassland communities.- The potential of phy- Cells and the Future Treatment of Neurologic Dis- tophagous insects in restoring invaded ecosystems.- eases: Raising the Standard.- Neural Differentiation Plant-insect-pathogen interactions on local and re- of Human Embryonic Stem Cells.- Generating Neu- gional scales.- Food web interactions and ecosystem rons from Stem Cells.- Isolation of Neural Stem and processes.- The role of outbreaking insects in [..] Precursor Cells from Rodent Tissue.- Adult Rodent Fields of interest Spinal Cord Derived Neural Stem Cells: Isolation Animal Ecology; Plant Ecology; Invertebrates; and Characterization.- Adult Neural Stem Cells.- Ecosystems; Biodiversity; Population Ecology Olfactory Ensheathing Cells: Isolation and Culture from the Olfactory Bulb and Olfactory Epithelium.- Target groups Production and Characterization of Immortal Hu- Researchers and advanced students man Neural Stem Cell Line with Multipotent [..] Type of publication Fields of interest Reference work Neurosciences; Cell Biology; Neurobiology

Target groups Due October 2007 Stem cell scientists, neuroscientists, investigators, fellows, and students 2008. XXI, 413 p. 50 illus. (Ecological Studies, Vol. 173) Softcover

Type of publication 59,95 € Contributed volume ISBN 978-3-540-74003-2

Due April 2008

2008. Approx. 480 p. 51 illus. 2 in color (Methods in Molecular Biology, Vol. 438) Hardcover

76,95 € ISBN 978-1-58829-846-1 springer.com/booksellers Life Science 140

V. Weissig, Northeastern University, Boston, MA, USA (Ed.) J. Westendorf, Mayo Clinic, Rochester, MN, USA (Ed.) G.E. Wickens, B.Sc. M.Sc. (University of Wales), Ph.D. (University of Reading), F.L.S., Retired Head of Economic Botany, Royal Botanic Gardens, Kew, UK; P. Lowe, B.A. (Liverpool University), M. Psych. Liposomes Osteoporosis (University of Western Australia); Master of Public Health and Tropical Medcine (James Cook University, Queensland) Methods and Protocols

Liposomes are the prototype of all nano drug deliv- The Baobabs ery vectors currently under development and lessons In recent years, the study of bone cells and tissues at The Pachycauls of Africa, Madagascar and Australia learned in the history of 40 years of Liposome Tech- the cellular and molecular levels in a variety of mod- nology should be heeded by new investigators in the els has revolutionized the field. In Osteoporo- emerging field of pharmaceutical and biomedical sis: Methods and Protocols, leading scientists from nanotechnology. This book compiles protocols, writ- This is the definitive and only comprehensive ac- around the world share their step-by-step laborato- ten by experts in their particular field, for a vast vari- count of all eight species in the genus Adansonia. It ry protocols for studying bone biology. The ety of liposome applications. It is an essential describes the historical background from the late Ro- topics covered in this volume include in vitro source of practical know-how for every investigator, man period to the present. It covers the extraordi- models, in vivo models utilized for drug testing, tis- whose research area involves in one way or another nary variety of economic uses of baobabs, famous sue engineering and osteoporosis studies in phospholipids, glycolipids and cholesterol. trees, folk traditions and mythology, art associations, either gender, state-of-the-art molecular techniques life cycle, natural history, conservation, cultivation, to assess single genes or for global genomic Fields of interest conservation, distribution and ecology, and phyto- analysis, powerful imaging techniques, and many Biochemistry, general; Cell Biology; Human Physiol- geography. There are also appendices on vernacu- more. As a volume in the highly successful ogy; Immunology; Pharmacology/Toxicology lar names, gazetteer, economics, nutrition and for- Methods in Molecular Biology™ series, each chap- est mensuration. This book fills a gap in the botani- ter provides a brief introduction, a list of necessary Target groups cal literature. It deals with a genus that has fascinated materials, and a Notes section detailing tips on trou- Membrane biologists and physicists, protein and and intrigued scientists and lay persons for centuries. bleshooting and avoiding known pitfalls. Compre- lipid biochemists, molecular biologists, immunolo- It will appeal to scientists and academics as well as hensive and cutting-edge, Osteoporosis: Methods gists, and pharmaceutical scientists tropical horticulturalists, conservationists and gener- and Protocols is the perfect guide for both new and al interest readers. It includes all the available scien- Type of publication experienced experimentalists attempting [..] tific information about each of the eight species, and Contributed volume Features contains a good deal of original research on the history, ethnobotany and biology of the genus. There is Due September 2009 Includes CD with full color reproduc- tions of many figures within the book Contains even a [..] simple and complete protocols for culturing os- Features 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary teoblasts and osteoclasts Explains how to uti- First and only fully comprehensive account of entry 2260) Hardcover lize various rodent models to study and treat os- all eight species of Adansonia Contains much teoporosis Provides protocols for increas- 76,65 € new information Highly interesting for scien- ing or decreasing gene expression in bone cells ISBN 978-1-60327-359-6 tists, academics and laypeople Examines molecular, genetic and imaging techniques to study [..] Contents Preface; Foreword; Acknowledgements; Colour Contents Plates; 1. Historical Background; 2. Famous Baoba- Isolation and Culture of Rodent Osteoprogenitor bs; 3. Folklore and Tradition; 4. Food and Fodder; 5. Cells.- Osteoclast Culture and Resorption Assays.- Human and Veterinary Medicine; 6. Other Uses of Assessing New Bone Formation in Neonatal Calvar- the Baobab; 7. Art and Iconography; 8. Baobab Bi- ial Organ Cultures.- Detection of Apoptosis of Bone ology; 9. Natural History; 10. Conservation; 11. Cul- Cells In Vitro.- In Vivo Parathyroid Hormone Treat- tivation; 12. Taxonomy; 13. Distribution and Ecol- ments and mRNA Isolation and Analysis.- Assess- ogy; 14. Phytogeography; 15. Unfinished Business; ment of Bone Formation Capacity Using In Vivo Appendix 1. Vernacular Names; Appendix 2. Eco- Transplantation Assays: Procedure and Tissue Anal- nomics; Appendix 3. Nutrition; Appendix 4. Forest ysis.- Ossicle and Vossicle Implant Model Systems.- Mensuration; References; Taxonomic Indexes; Sub- Utility of the Ovariectomized (OVX) Rat as a Mod- ject Index; Gazetteer el for Human Osteoporosis In Drug Discovery.- Or- chidectomy (ORX) Models of Osteoporosis.- Gene Fields of interest Delivery [..] Tree Biology; Forestry; Agricultural Economics; Na- ture Conservation; Agriculture Fields of interest Cell Biology; Orthopedics; Molecular Medicine; Target groups Geriatrics/Gerontology; Imaging / Radiology Ethnobotanists and nutritionists interested in the use of the baobab’s roots, leaves, flowers and fruit for Target groups food (rich in vitamin C, minerals, amino-acids, etc.), Bone biologists, osteopaths, laboratory researchers Pharmacognosists interested in the tree’s medicinal Type of publication properties, botanists, zoologists and conservationists Contributed volume concerned with baobabs and their rich flora and fauna associates, Ethnologists interested in the varied legends, myths and folklore of the baobabs, General Due June 2008 public who have a genuine fascination of baobabs.

2008. Approx. 425 p. 74 illus., 5 in color. (Methods in Molecular Type of publication Biology, Preliminary entry 1999) Hardcover Monograph

99,95 € Due October 2007 ISBN 978-1-58829-828-7

2007. xl, 448p. Hardcover

115,00 € ISBN 978-1-4020-6430-2 springer.com/booksellers Life Science 141

M. Wilks, St. Bartholomew's Hospital, London, UK (Ed.) M. Wilks, St. Bartholomew's Hospital, London, UK (Ed.) D.M. Williams, Natural History Museum, London, UK; M.C. Ebach, Botanic Garden and Botanical Museum Berlin-Dahlem, Freie Universität Berlin, Germany PCR Detection of Microbial PCR Detection of Microbial Pathogens Pathogens Foundations of Systematics and Volume 1 Volume 2 Biogeography

This volume draws attention to the seminal studies Fields of interest Fields of interest and important advances that have shaped systemat- Microbiology; Cell Biology Microbiology; Cell Biology ic and biogeographic thinking and continue to influence its direction today. It traces concepts in homol- Type of publication Type of publication ogy and classification from the 19th century to the Contributed volume Contributed volume present through the provision of a unique anthology of scientific writings from Goethe, Agassiz, Geoffroy Due September 2009 Due September 2009 St. Hilaire, Owen, Naef, Zangerl and Nelson, among others. In addition, current attitudes and practices in 2009. Approx. 300 p (Methods in Molecular Biology, Vol. 216) 2009. Approx. 300 p (Methods in Molecular Biology, Preliminary comparative biology are interrogated, particularly in Hardcover entry 2251) Hardcover relation to evolutionary studies leading to a re-state- ment of the principal aims of the discipline. In order 76,65 € 76,65 € to alert prospective students to pitfalls common in ISBN 978-1-60327-352-7 ISBN 978-1-60327-348-0 systematics and biogeography, the book highlights three principal messages: biological classifications and their explanatory mechanisms are separate notions; most, if not all, homology concepts pre-date the works of Darwin; and that the foundation of all comparative biology is the concept of relationship – neither 'similarity' [..]

Features will explode some myths currently part of biology and reassert – and re-state – the principal aims of comparative biology, especially in relation to evolutionary studies

Contents Introduction - Systematics, Evolution and Clas- sification.- Systematics as Problem-Solving.- The Archetype.- Ernst Haeckel and Systematische Phy- logenie.- The German Development of Morpholo- gy: From Ernst Haeckel to Willi Hennig.- Pattern Cladistics.- Homologues and Homology.- Discover- ing Homologues.- Homology and Systematics.- Ho- mology and Transformation.- Character Conflict.- The Analyses of Relationships.- Biogeographical Re- lationships, Evolution and Classification.

Fields of interest Human Genetics; Cell Biology; Evolutionary Biology

Target groups Third year undergraduates to graduates, academics/professionals

Type of publication Monograph

Due December 2007

2008. Approx. 200 p. Hardcover

62,95 € ISBN 978-0-387-72728-8 142 Life Science springer.com/booksellers

R.J. Willis, University of Melbourne, Parkville, VIC, Australia J. Wilusz, Colorado State University, Fort Collins, CO, USA (Ed.) S. Wu-Pong, Virginia Commonwealth University, Richmond, VA; Y. Rojanasakul, West Virginia University, Morgantown, WV, USA (Eds.) The History of Allelopathy Post-Transcriptional Gene Regulation Biopharmaceutical Drug Design and Development This book firstly addresses the question of what is allelopathy, as allelopathy is one of these unfortunate This volume strives to present current technical ap- terms in ecology that has no unified definition. The proaches to most aspects of post-transcriptional con- book then examines the major episodes in the histo- trol and provide the reader with a useful and versa- Biopharmaceutical Drug Design and Development, ry of allelopathy: the writings from classical Greece tile laboratory bench resource. With chapters split Second Edition, furthers the widely successful first and Rome; mediaeval Arabic, Indian and Chinese into sections covering bioinformatics, fundamental edition, published in 1999. This new, expanded edi- work; the advent of printing and promulgation of in- aspects of the study of RNA biology, and techniques tion investigates the dozens of new biopharmaceuti- formation in the 16th and 17th centuries; the 18th for specific aspects of RNA biology, the expert au- cal drugs that have become available since that time. century and the theory of root excretion; the 19th thors have filled the book with invaluable tricks of Among the drugs discussed are ones in the cate- century and the influence of A.P. de Candolle; the the trade, perfected in their state-of-the-art laborato- gories of monoclonal antibodies for in-vivo use, cy- early 20th century and the work of Pickering and the ries. tokines, growth factors, enzymes, immunomodula- USDA Bureau of Soils; and the years leading to the tors, thrombolytics, and immonotherapies includ- current era. The work draws extensively on original Features ing vaccines. Additionally, the volume examines new sources, and consequently many of the assertions Step-by-step instructions that ensure successful re- and emerging technologies, such as bioinformatics, published in relation to the background of allelopa- sults Tricks of the trade and notes on troubleshoot- DNA microarrays, transgenics, therapeutic gene de- thy, are shown to be incorrect, or at best very inad- ing and avoiding known pitfalls livery, stem cells, nucleic acid-based therapeutics, equate. There is a great deal of information present- and macromolecular drug delivery. Authors also ed, in a consolidated or accessible form, for the first Contents study pharmacogenetics in the clinic and changes in time. The book endeavours to set the history of al- Preface.- Contributors.- Bioinformatics Approach- biologic drug approval at the FDA. Biopharmaceuti- lelopathy within both a [..] es for Studying Untranslated Regions of mRNAs.- cal Drug Design and Development, Second Edition, Identification of mRNA Polyadenylation Sites in is a worthy sequel to a discussion on the dynamic, Features genomes Using cDNA Sequences, Expressed Se- exciting field of biotechnology. First work to document in detail the history of al- quence Tags and Trace.- Bioinformatic Tools for lelopathy Material presented in English for the first Studying Post-Transcriptional Gene Regulation: The Features time, e.g. from Latin, Indian, Chinese, Arabic sources UAlbany TUTR (Training UTR) Collection and oth- Comprehensive examination of the newest biophar- Unique insight into the historical factors which have er Informatic Resources.- In-Line Probing Analy- maceutical drugs Detailed investigation of revolu- swayed the popularity of allelopathy through the ages sis of Riboswitches.- Ribotrap: Targeted Purifica- tionary inventions and techniques, including cloning tion of RNA-Specific RNPs from Cell Lysates via Im- and microarray technology Review of the Human Contents munoaffinity Precipitation to Identify Regulatory Genome Project Illustrations.- Acknowledgements.- Foreword.- 1. Proteins and RNAs.- Advances in RIP-Chip Analy- What is Allelopathy?.- 2. Allelopathy in the Classi- sis: RNA-Binding [..] Contents cal World - Greece and Rome.- 3. Arabic Works.- 4. Biotechnology: 2005 and Beyond.- Human Genome Ancient India, China and Japan.- 5. Mediaeval Peri- Fields of interest Project.- Bioinformatics.- DNA Microarrays in Drug od and Renaissance.- 6. The Eighteenth Century – Cell Biology; Human Genetics; Bioinformatics Discovery and Development.- Microarray Technol- Root Excretion.- 7. Augustin Pyramus de Candolle, ogy Using Proteins, Cells, and Tissues.- Pharma- and His Era.- 8. The Decline of Allelopathy in the Target groups cogenetic Issues in Biopharmaceutical Drug Devel- Latter Nineteenth Century.- 9. Spencer Pickering, Geneticists, cell biologists, bioinformaticians opment.- Transgenics.- Therapeutic Gene Deliv- and The Woburn Experimental Fruit, 1894-1921.- ery.- Stem Cells.- Nucleic Acid Based Therapeutics.- 10. The USDA Bureau of Soils and Its Influence.- 11. Type of publication Therapeutic Strategies Targeting the Innate Immune Approaching the Modern Era.- Index. Contributed volume Response.- Pharmacogenetics in the Clinic.- Molecu- lar Modeling: Considerations for the Design of Phar- Fields of interest Due December 2007 maceuticals and Biopharmaceuticals.- Macromolec- Life Sciences, general; Plant Sciences; Plant Ecology; ular Drug Delivery.- Changes in Biologic Drug Ap- Agriculture proval at [..] 2008. Approx. 450 p. 56 illus. (Methods in Molecular Biology, Vol. 419) Hardcover Target groups Fields of interest Graduate students, researchers concerned with al- 79,95 € Pharmacology/Toxicology; Cell Biology; Biochem- lelopathy, plant ecology, agriculture; graduate stu- ISBN 978-1-58829-783-9 istry, general; Pharmacy dents, researchers concerned with history of botany Target groups Type of publication Graduate students and post-docs, pharmacologists, Monograph molecular biologists, biochemists, biologists

Due October 2007 Type of publication Contributed volume

2007. Approx. 316 p. Hardcover Due November 2007 134,95 € ISBN 978-1-4020-4092-4 2007. Approx. 450 p. 27 illus., 3 in color. Hardcover

104,95 € ISBN 978-1-58829-716-7 springer.com/booksellers Life Science 143

Z. Xu, Peking University, China; J. Li, Institute of Genetics & Devel- A.Y. Yakovlev, University of Rochester, Rochester, NY, USA; L. Kle- S. Yanniotis, Agricultural University of Athens, Greece opmental Biology, CAS, Beijing, China; Y. Xue, Institute of Genet- banov, Charles University, Prague, Czech Republic; D. Gaile, State ics & Developmental Biology, CAS, Beijing, China; W. Yang, Insti- University of New York at Buffalo, Buffalo, NY, USA (Eds.) tute of Genetics & Developmental Biology, CAS, Beijing, China Solving Problems in Food (Eds.) Statistical Methods for Microarray Engineering Biotechnology and Sustainable Data Analysis Agriculture 2006 and Beyond Solving Problems in Food Engineering is a step by step workbook intended to enhance students' un- Proceedings of the 11th IAPTC&B Congress, August 13-18, The modern state of the art in methodology of mi- 2006 Beijing, China derstanding of complicated concepts and to help croarray data analysis based on significance testing them practice solving food engineering problems. is far from satisfactory. However "hot" this method- The book covers problems in fluid flow, heat trans- ological research trend has been, it is still in its in- fer, mass transfer, and the most common unit opera- Biotechnology and Sustainable Agriculture 2006 and fancy and a real revolution in the field definitely lies tions that have applications in food processing, such Beyond is a collection of papers presented at the XIth ahead. In particular, the basic statistical problems as thermal processing, cooling and freezing, evapora- international congress of the International Associa- will remain the same even after new digital technolo- tion, psychrometrics and drying. Included are theo- tion of Plant Tissue Culture & Biotechnology gies produced by Solexa and some other companies retical questions in the form of true or false, solved (IAPTC&B). It continues the long tradition of have become widely available. This volume "Statis- problems, semi-solved problems, and problems the IAPTC&B to publish the proceedings of its tical Methods for Microarray Data Analysis" will in- solved using a computer. The semi-solved problems quadrennial congresses. It provides an up-to-date re- clude selected papers on this subject that meet a high guide students through the solution. Some of the port of the most significant advances in plant tissue standard of mathematical rigor. problems progress from elementary level increasing culture and biotechnology as presented by leading difficulty so that the book is useful to food science Fields of interest international scientists. as well as food engineering students. A CD-Rom is Statistics for Life Sciences, Medicine, Health Sci- supplied with the book, which contains spreadsheet ences; Computer Appl. in Life Sciences; Biotechnolo- Features solutions of problems that require the use of a com- gy; Human Genetics Provides an excellent summary of the latest advances puter, such as transient heat and mass transfer prob- in plant sciences Offers the most updated develop- lems, simulation of 2 and 4-effect evaporators, [..] ment in plant tissue culture Brings the state-of-the- Target groups Biostatisticians, molecular and cellular biologists art technology in plant biotechnology Features introduction to food engineering problems for those Contents Type of publication Contributed volume who have very little to no background in engineering Advances In Plant Molecular Biology.- Functional supplemental text that covers the basics of food engi- Genomics.- Plant Transformation Technology.- In neering problem solving a progressive degree of dif- Vitro System As The Model For Discovery In Molec- Due September 2009 ficulty in the questions ular Biology.- Molecular Control Of Abiotic Resis- tance.- Plant Insect Interaction.- Molecular Mech- 2009. Approx. 300 p (Methods in Molecular Biology, Preliminary Contents anisms On Plant-Microbe Interactions.- Metabol- entry 2246) Hardcover Conversion of units.- Use of steam tables.-Mass bal- ic Engineering.- Improving Nutritional Quality Of ance.- Enthalpy balance.- Mechanical energy bal- Crops.- Signal Transduction.- Apomixis.- Biotech- 76,65 € ance.- Fluid flow.- Selection of a pump.- Heat trans- nology In Cereals.- Biotechnology In Economic ISBN 978-1-60327-336-7 fer by conduction (single and multiple-layer flat Crops.- Biotechnology In Medicinal, Woody And and cylindrical wall).- Heat transfer by convection Horticultural Plants.- Tissue Culture For Biodiver- (calculation of heat transfer coefficient, overall heat sity Preservation.- Plants As Bioreacter/Molecular transfer coefficient, area of heat exchanger).- Heat Pharming.- [..] transfer by radiation.- Unsteady state heat conduction.- Mass transfer by diffusion.- Mass transfer be- Fields of interest tween phases.- Unsteady state mass transfer.- Evap- Plant Sciences; Biotechnology; Plant Genetics & Ge- oration.- Psychometrics.- Drying.- Freezing.- Mi- nomics; Developmental Biology; Agriculture; Cell crowave heating.- Separation in [..] Biology Fields of interest Target groups Food Science Agricultural scientists, plant breeders and geneticists, plant biotechnologists, biotech industry, internation- Target groups al policy makers upper level undergraduate students in food engineering Type of publication Proceedings Type of publication Graduate/advanced undergraduate textbook Due October 2007 Due December 2007 2008. Approx. 450 p. Hardcover 2008. Approx. 345 p. With CD-ROM. (Food Engineering Series) 145,00 € Softcover ISBN 978-1-4020-6634-4 53,90 € ISBN 978-0-387-73513-9 144 Life Science springer.com/booksellers

F. Yiannas, Walt Disney World Company, Lake Buena Vista, FL, X.-M. Yin, University of Pittsburgh School of Medicine, Pitts- D. Yu, The University of Texas M.D. Anderson Cancer Center, USA burgh, PA, USA; Z. Dong, Medical College of Georgia, Augusta, Houston, TX, USA; M.-C. Hung, The University of Texas M.D. An- GA, USA (Eds.) derson Cancer Center, Houston, TX, USA (Eds.) Food Safety Culture Essentials of Apoptosis Breast Cancer Chemosensitivity Creating a Behavior-Based Food Safety Management System A Guide for Basic and Clinical Research

In Breast Cancer Chemosensitivity, a group of world Food safety awareness is at an all time high, new and leading experts review critical aspects of resistance to This is the second edition of the comprehensive, emerging threats to the food supply are being rec- systemic therapy in breast cancer patients. Beginning concise summary of apoptosis research. It covers ognized, and consumers are eating more and more with a clinical overview of the problem Breast Can- the major concepts, molecular architecture, the bio- meals prepared outside of the home. Accordingly, re- cer Chemosensitivity moves on to focus on the latest chemical pathways, and pathophysioloical signifi- tail and foodservice establishments, as well as food findings of molecular mechanisms of drug resistance. cance of apoptosis. This book provides a guideline of producers at all levels of the food production chain, These include in-depth discussions on multidrug re- standard biochemical and cell biologic approaches have a growing responsibility to ensure that prop- sistance by P-glycoprotein and the multidrug resis- to apoptosis bench work with an emphasis on trans- er food safety and sanitation practices are followed, tance protein family, resistance to therapeutic agent- lational clinical applications for immune disorders, thereby, safeguarding the health of their guests and induced apoptosis, cell cycle deregulation, deregula- cancer research, ischemia, and neuronal degenera- customers. Achieving food safety success in this tion of DNA repair, loss of tumor suppressor genes, tion. Since the original publication in 2003, the apop- changing environment requires going beyond tradi- integrin-mediated adhesion, insulin-like growth fac- tosis field has expanded rapidly – chapters not only tional training, testing, and inspectional approach- tors, epidermal growth factor, and ErbB2 in mod- need to be revised and expanded, but there is a need es to managing risks. It requires a better understand- ulating breast cancer response to systemic therapy, for all new chapters covering exciting advances in ing of organizational culture and the human dimen- especially, certain chemotherapeutic agents. Breast bioinformatics, systems biology, oxidative stress, etc. sions of food safety. To improve the food safety per- Cancer Chemosensitivity provides an example of formance of a retail or foodservice establishment, an using novel approaches for chemosensitization of organization with thousands of employees, or a lo- Contents Caspases.- Bcl-2 family proteins.- IAP.- breast cancer cells that gives readers an idea about cal community, you must change the way people do the future direction in breast cancer treatment. things. You must change their behavior. In fact, sim- Structure Biology.- The death receptor pathway.- The mitochondrial pathway.- ply put, food safety equals behavior. [..] Features Alternative pathway.- Bioinformatic of apop- A useful reference to some of the most impor- tosis.- Systems approach to apoptosis.- Features tant aspects of systemic therapy resistance Allows Clearance of apoptotic bodies by phagocyto- the first significant contribution on how to create a those who are interested in breast cancer therapy to sis.- Bioenergistics of cell death.- ER-Mitochon- behavior-based food safety management system get a jump-start on critical issues in breast cancer dria cross talk and ER stress induced apopto- therapeutic resistance Contents sis.- Transcriptional Regulation of apoptosis.- Introduction.- Looking Back to Shape the Fu- Apoptosis in plants, yeast and bacteria.- PCD Fields of interest ture.- Why the Focus on Culture?- A in C. elegans.- PCD in Drosophila.- Cell death in Cancer Research; Biochemistry, general; Molecular Systems Based Approach to Food Safety.- mammalian development.- Apoptosis and Medicine; Cell Biology Creating Food Safety Performance Expecta- cancer.- Apoptosis in immune system and [..] tions.- Educating and Training to Influence Target groups Behavior.- Communicating Food Safety Effec- Fields of interest All health-care providers charged with the care of tively.- Developing Food Safety Goals & Cell Biology; Biochemistry, general; Neurosciences; women: primary care physicians, gynecologists, on- Measurement Systems.- Using Consequences to Immunology; Human Physiology cologists, radiologists, surgeons, gerontologists, in- Increase or Decrease Behaviors.- Tying it all To- ternal medicine specialists gether — Food Safety Performance Manage- Target groups ment.- Unwrapping — Thoughts on the Fu- Cell biologists, microbiologists, biochemists Type of publication ture of Food Safety.- Index. and first year PhD students Contributed volume Type of publication Fields of interest Due October 2007 Food Science; Nutrition Contributed volume

Target groups Due April 2009 2008. Approx. 190 p. (Advances in Experimental Medicine and food safety professionals involved with the retail and Biology, Vol. 608) Hardcover foodservice industry (the largest segment of the food 2009. Approx. 400 p. Hardcover 114,95 € chain) as well as to quality assurance professionals ISBN 978-0-387-74037-9 working in food processing plants, Federal 92,40 € regulatory officials (FDA, USDA, CDC), and profes- ISBN 978-1-60327-380-0 sionals employed by state agricultural agencies and local health departments

Type of publication Monograph

Due January 2008

2008. Approx. 200 p. (Food Microbiology and Food Safety) Hard- cover

61,60 € ISBN 978-0-387-72866-7 springer.com/booksellers Life Science 145

M. Zaki, Rensselaer Polytechnic Institute, Troy, NY, USA; C. T. Zhu, Syngenta Biotechnology, Inc., Research Triangle Park, NC, P. Zugenmaier, Technische Universität Clausthal, Clausthal- Bystroff, Rensselaer Polytechnic Institute, Troy, NY, USA (Eds.) USA (Ed.) Zellerfeld, Germany

Protein Structure Prediction Genome Profiling for Genetic Crystalline Cellulose and Cellulose Marker Discovery Derivatives

Characterization and Structures This book covers elements of both the data-driven comparative modeling approach to structure pre- Recent advancement in genome technology, espe- diction and also recent attempts to simulate folding cially high throughput low cost sequencing and mi- using explicit or simplified models. Despite the un- This book constitutes a valuable, concise and up- croarrays, revolutionizes the way for discovering ge- solved mystery of how a protein folds, advances are to-date guide for the materials and life science com- netic markers and enables their new applications. being made in predicting the interactions of proteins munity interested in cellulose and related materi- This volume is designed to build a genetic tool box with other molecules, such as small ligands, nucle- als. Reliable crystal structures of all cellulose poly- with these emerging techniques for molecular biol- ic acids or other proteins. Also rapidly advancing morphs and cellulose derivatives determined are crit- ogists, geneticists, clinical scientists and breeders. are the methods for solving the inverse folding prob- ically reviewed and discussed. Models are represent- While theses methods and protocols were developed lem, the problem of finding a sequence to fit a struc- ed in graphs together with a collection of geometri- in genomics and bioinformatics laboratories in the ture. This book focuses on the various computation- cal data as well as the atomic coordinates for further forefront of the fields, the format of each method or al methods for prediction, their successes and their use. The background for fiber diffraction, comput- protocol is easy to understand and practical to ad- limitations, from the perspective of their most well er-aided modeling and spectroscopic investigations dress different challenging issues in genetic marker known practitioners. is briefly introduced and also included are the neces- discovery. sary molecular data from oligosaccharides as a basis Features Fields of interest for structure evaluations. X-ray diffraction patterns Describes cutting-edge techniques for prediction Human Genetics; Bioinformatics; Molecular and spectroscopic diagrams are presented as refer- and accesses them from the perspective of their most Medicine ences to characterize cellulosic materials and to serve well-known practitioners Includes a comprehensive as fingerprint tools for the exploration of unknown account of the history of protein structure prediction Target groups specimens of cell walls and of industrially processed Step-by-step, readily reproducible laboratory proto- Molecular biologists, geneticists, clinical scientists films and fibers as well as solid-state materials. Cellu- cols Chapters written by experienced practitioners and breeders lose as an abundant renewable material has stimulated basic and applied [..] Contents Type of publication A historical perspective of template-based protein Contributed volume Features structure prediction.- The assessment of methods for A valuable, concise and up-to-date guide for the Ma- protein structure prediction.- Aligning Sequences Due September 2009 terials and Life Science community interested in cel- to Structures.- Protein Structure Prediction Using lulose and related materials Critical survey on struc- Threading.- Algorithms for Multiple Protein Struc- tures and characterization of cellulosics Fiber diffrac- ture Alignment and Structure-Derived Multiple Se- 2009. Approx. 300 p. (Methods in Molecular Biology, Preliminary tion by X-ray, neutron scattering, electron diffraction quence Alignment.- Indexing Protein Structures us- entry 2258) Hardcover on polymeric single crystals, computer-aided mod- ing Suffix Trees.- Hidden Markov Models for Predic- 76,65 € eling Critical evaluation of up-to-date structure pro- tion of Protein Features.- The pros and cons of pre- ISBN 978-1-60327-350-3 posals of native as well as regenerated and [..] dicting protein contact maps.- Roadmap Methods for Protein Folding.- Scoring functions for de novo Fields of interest protein structure prediction revisited.- [..] Agriculture; Forestry; Plant Sciences

Fields of interest Target groups Biochemistry, general; Proteomics libraries, institutes, scientists

Target groups Type of publication Cell biologists, biochemists, biotechnologists, geneti- Monograph cists, pharmacologists Due October 2007 Type of publication Contributed volume 2008. X, 285 p. 146 illus. (Springer Series in Wood Science) Hard- cover Due October 2007 159,95 € 2007. Approx. 280 p. 69 illus. (Methods in Molecular Biology, Vol. ISBN 978-3-540-73933-3 413) Hardcover

79,95 € ISBN 978-1-58829-752-5 146 Life Science springer.com/booksellers

P. beim Graben, University of Potsdam, Germany; C. Zhou, Uni- C. dos Remedios, The University of Sydney, NSW, Australia; D. K. von Gadow, University of Göttingen, Germany; T. Pukkala, Uni- versity of Potsdam, Germany; M. Thiel, University of Potsdam, Chhabra, The University of Sydney, NSW, Australia (Eds.) versity of Joensuu, Finland (Eds.) Germany; J. Kurths, University of Potsdam, Germany (Eds.) Actin-Binding Proteins and Disease Designing Green Landscapes Lectures in Supercomputational Neurosciences

Dynamics in Complex Brain Networks Actin is a ubiquitous protein present in high concen- Von Gadow and Pukkala’s unique, Designing Green trations in virtually all cells. It's assembly and disas- Landscapes, presents the latest thinking in adaptive sembly is modulated by more than 100 actin-binding management for forest ecosystems. Based on the proteins. These interactions are essential for a vari- ‘multiple path’ principle, this approach links species Computational Neurosciences is a burgeoning field ety of important cellular processes including cell di- choice and silvicultural methods with changing de- of research where only the combined effort of neuro- vision, gene expression and motility. There are scat- mands and changing environmental conditions, to scientists, biologists, psychologists, physicists, math- tered reports in the published literature citing rela- ensure continuous adaptation, often several times ematicians, computer scientists, engineers and other tionships between actin, actin-binding proteins and within the lifetime of a tree. The ‘multiple path’ prin- specialists, e.g. from linguistics and medicine, seem disease. This volume brings this information togeth- ciple at the core of this approach represents a ro- to be able to expand the limits of our knowledge. The er for the first time, with a focus on human disor- bust theoretical framework for designing forested present volume is an introduction, largely from the ders. This volume is relevant to a wide readership landscapes. It provides a logical basis both for coor- physicists' perspective, to the subject matter with including cell biologists interested in understand- dinating spatial objectives and for integrating var- in-depth contributions by system neuroscientists. ing how structural and functional changes in pro- ied forms of expertise; it limits planning horizons A conceptual model for complex networks of neu- teins impact on the organism as a whole. Additional- to realistic timeframes; and it allows for forecasts rons is introduced that incorporates many impor- ly, clinicians will be interested because the book ex- based on current real attributes of spatially explicit tant features of the real brain, such as various types plains the role of cytoskeletal proteins in various dis- land parcels. This is in stark contrast with tradition- of neurons, various brain areas, inhibitory and exci- eases, including cancer and immune system disor- al forestry practices which simply assess the forest re- tatory coupling and the plasticity of the network. The ders. source at regular time intervals and prescribe stan- computational implementation on supercomputers, dard management schedules for specific forest types. which is introduced and discussed in detail in this Features Presenting what is [..] book, will enable the readers to modify and adapt the Will appeal to research scientists seeking contempo- algortihm for their own research. Worked-out ex- rary overviews of actin-myosin interaction and actin- Features amples of applications are presented for networks of based regulation Coordinated theme/technique High profile scien- Morris-Lecar neurons to model [..] tists Level of current management activity that the Contents book addresses Need for better landscape manage- Contents Overview of actin.- Actin Genetic Diseases.- Actin- ment/planning tools and techniques Neurophysiology.- Complex Networks.- Cognition binding drugs.- Filamentous actin as an autoanti- and Higher Perception.- Implementations.- Applica- gen.- Actin Binding Protein Function and its Rela- Contents tions.- Index. tion to Disease Pathology.- ADF/cofilin, actin dy- Section 1: Introduction. 1. Adaptive design of forest- namics and disease.- Gelsolin and disease.- Profilin ed landscapes; K. v. Gadow et al.- Section 2: Assess- Fields of interest and disease.- The roles of thymosin beta4 in cell mi- ing the Landscape. 2. Landscape metrics, scales of Biophysics; Nonlinear Dynamics, Complex Systems, gration and cell-to-cell signalling in disease.- Actin resolution; S.A. Cushman, K. McGarigal.- 3. De- Chaos, Neural Networks; Artificial Intelligence (incl. and actin binding proteins in cancer progression tailed assessment using remote sensing techniques; Robotics); Neurosciences; Numerical and Computa- and metastasis.- Defects in actin and actin-binding P. Packalén et al.- 4. Assessing landscape attributes; tional Methods proteins in leukocytes.- The role of PIP2 in actin, C. Kätsch.- Section 3: Numerical Analysis of Land- actin-binding proteins and disease.- Intracellular scape Design. 5. Spatial optimisation - computation- Target groups pathogens and the actin [..] al Methods; P. Bettinger, Y.-H. Kim.- 6. Integrating Graduate students, lecturers, researchers multiple services in the numerical analysis of land- Fields of interest scape design; T. Pukkala.- 7. Decentralized forest Type of publication Proteomics; Cell Biology; Biochemistry, general planning models - a cellular [..] Monograph Target groups Fields of interest Due November 2007 Researchers, academicians, and graduate students in Environment, general; Life Sciences, general; Envi- cellular biology, medical research, biochemistry, bio- ronmental Management; Computer Appl. in Life Sci- physics, molecular biology, and proteomics 2008. X, 375 pages with 179 illus. (Understanding Complex Sys- ences; Landscape Ecology tems) Hardcover Type of publication Target groups 79,95 € Contributed volume Primarily as a reference text for researchers and ISBN 978-3-540-73158-0 graduate students in forest management, ecology, Due November 2007 modelling and landscape planning – particularly in Europe and North America, perhaps eastern Asia as well. Additional professional market among Land 2008. Approx. 300 p. (Protein Reviews, Vol. 8) Hardcover Management Agencies and environmental consul- 139,95 € tants. ISBN 978-0-387-71747-0 Type of publication Contributed volume

Due January 2008

2008. Approx. 310 p. (Managing Forest Ecosystems, Vol. 15) Hardcover

115,00 € ISBN 978-1-4020-6758-7 Order Now! Springer Customized Book List

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