Adrianne M. Rosales Assistant Professor CPE 3.418 email: [email protected]

EDUCATION Ph.D. Chemical Engineering, May 2013 University of California, Berkeley – Berkeley, CA Advisor: Professor Rachel A. Segalman Dissertation: “Nanostructure Control of Biologically Inspired Polymers”

B.S. Chemical Engineering, May 2007 The University of Texas at Austin – Austin, TX Graduated magna cum laude

RESEARCH & WORK EXPERIENCE

Postdoctoral Fellow 07/2013 - present Department of Chemical and Biological Engineering, University of Colorado, Boulder Lab of Professor Kristi Anseth Visiting Scholar in lab of Jason Burdick, University of Pennsylvania (09/2014 - present) Graduate Research Assistant 08/2007 – 05/2013 Department of Chemical & Biomolecular Engineering, University of California, Berkeley Labs of Professor Rachel A. Segalman & Dr. Ronald N. Zuckermann (LBNL) Undergraduate Research Assistant 01/2005 – 05/2007 Department of Chemical Engineering, University of Texas at Austin Lab of Professor Nicholas A. Peppas Polypropylene Licensing& Catalyst Intern 05/2006 – 08/2006 Dow Chemical Company – South Charleston, WV Beauty Care R&D Intern 06/2005 – 08/2005 Procter & Gamble – Cincinnati, OH

FELLOWSHIPS AND AWARDS 2015 University of Washington Distinguished Young Scholars Seminar series – co-winner 2015 Best Paper, session, 2014 AIChE National Meeting 2014 NIH Ruth L. Kirschstein NRSA F32 Postdoctoral Fellowship 2014 American Heart Association Postdoctoral Fellowship (declined to accept NIH F32) 2014 Burroughs Wellcome Fund Postdoctoral Enrichment Program Award 2012 University of California Dissertation Year Fellowship 2012 Carl Storm Underrepresented Minority Fellowship (2012 Bioinspired Materials GRC) 2007 National Science Foundation Graduate Fellowship 2007 University of California, Berkeley, Chancellor’s Fellowship 2006 Dow Outstanding Junior Award (University of Texas at Austin) 2005 ConocoPhillips SPIRIT Scholars Program (University of Texas at Austin) 2003 National Hispanic Scholar Finalist Scholarship 2003 Robert C. Byrd Scholarship 2003 College of Engineering Friends of Alec Scholarship (University of Texas at Austin) PUBLICATIONS

In Preparation 11. A.M. Rosales, C.B. Rodell, M. Chen, J.A. Burdick, K.S. Anseth. “Dynamic Mechanical Hydrogels for Modulation of Cell Phenotype.” Manuscript available upon request.

In Review/Published 10. E.M. Nehls, A.M. Rosales, K.S. Anseth. “Enhanced User-control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tether.” In review at Journal of Materials Chemistry B. 9. A.M. Rosales and K.S. Anseth. “Capturing Extracellular Matrix Dynamics with Reversible Hydrogels.” Nature Reviews Materials, invited review, in revision. 8. A.M. Rosales, K.M. Mabry, E.M. Nehls, K.S. Anseth. “Photoresponsive Elastic Properties of Azobenzene-Containing Poly(ethylene-glycol)-based Hydrogels.” Biomacromolecules 2015, 16(3), 798-806. 7. A.M. Rosales, R.A. Segalman, R.N. Zuckermann. “Polypeptoids: A Model System to Study the Effect of Monomer Sequence on Polymer Properties and Self-Assembly.” Soft Matter 2013, 9, 8400-8414. 6. H.K. Murnen*, A.M. Rosales*, A.V. Dobrynin, R.N. Zuckermann, R.A. Segalman. “Persistence Length of Polyelectrolytes with Precisely Located Charges.” Soft Matter 2013, 9, 90-98. 5. A.M. Rosales, B.L. McCulloch, R.N. Zuckermann, R.A. Segalman. “Tunable Phase Behavior of Polystyrene-Polypeptoid Block Copolymers” Macromolecules 2012, 45(15),6027-6035 4. A.M. Rosales, H.K. Murnen, S.R. Kline, R.N. Zuckermann, R.A. Segalman. “Measurement of the Persistence Length of Helical and Non-Helical Polypeptoids in Solution.” Soft Matter 2012, 8, 3673-3680. 3. H.K. Murnen, A.M. Rosales, J.N. Jaworski, R.A. Segalman, R.N. Zuckermann. “Hierarchical Self-Assembly of a Biomimetic Diblock Copolypeptoid into Homochiral Superhelices.” Journal of the American Chemical Society 2010, 132(45), 16112-16119. 2. A.M. Rosales, H.K. Murnen, R.N. Zuckermann, R.A. Segalman. “Control of Crystallization and Melting Behavior in Sequence Specific Polypeptoids.” Macromolecules 2010, 43(13), 5627-5636. 1. J.B. Thomas, J.H. Tingsanchali, A.M. Rosales, C.M. Creecy, J.W. McGinity, N.A. Peppas. “Dynamics of Poly(ethylene glycol)-tethered, pH Responsive Networks.” Polymer 2007, 48(17), 5042-5048.

PRESENTATIONS

14. Oral presentation (Invited). “Dynamic Self-Assembled Materials to Control Cellular Microenvironments and Mimic Biological Phenomena.” University of Washington Distinguished Young Scholars Seminar (DYSS), Seattle, WA, 2015. 13. Oral presentation. “A Strategy for Reversible Control of Hydrogel Modulus to Probe Myofibroblast Activation.” Society for Biomaterials Meeting, Charlotte, NC, 2015. 12. Oral presentation. “A Light-Responsive Strategy for Reversible Control of Elastic Modulus in PEG-based Hydrogels.” American Chemical Society, Denver, CO, 2015. 11. Oral presentation. “A Hydrogel-Based Cell Culture Platform with Reversible Stiffening via an Azobenzene-Containing Crosslinker.” American Institute for Chemical Engineers (AIChE), Atlanta, GA, 2014. *Recognized as a “Best Presentation” of the Biomaterials session 10. Poster presentation. “Reversibly Stiffening Hydrogels to Probe Myofibroblast Activation.” Signal Transduction in Engineered Extracellular Matrices Gordon Research Conference, Waltham, MA, 2014. 9. Oral presentation. “Reversibly Stiffening Hydrogels to Probe Myofibroblast Activation.” Society for Biomaterials Meeting, Denver, CO, 2014. 8. Oral presentation. “Self-Assembly of Peptoid Block Copolymers with Tunable Conformational Asymmetry.” APS March Meeting, Baltimore, MD, 2013. 7. Poster presentation. “Tunable Phase Behavior of Polypeptoid-Containing Block Copolymers.” 8th Peptoid Summit, Berkeley, CA, 2012. 6. Poster presentation. “Tunable Phase Behavior of Polypeptoid-Containing Block Copolymers.” Bioinspired Materials Gordon Research Conference, Davidson, NC, 2012. 5. Oral presentation. “Effect of Chain Shape on the Self-Assembly of Bioinspired Block Copolymers.” APS March Meeting, Boston, MA, February 2012. 4. Oral presentation. “Effect of Monomer Sequence on the Self-Assembly of Bioinspired Block Copolymers.” APS March Meeting, Dallas, TX, March 2011. 3. Poster presentation. “Self-assembly of Polypeptoid Block Copolymers in the Bulk.” 7th Peptoid Summit, Berkeley, CA, August 2010. 2. Oral presentation. “Self-assembly of Crystalline Bioinspired Block Copolymers.” APS March Meeting, Portland, OR, March 2010. 1. Oral presentation. “Self-assembly of Bioinspired Block Copolymers.” APS March Meeting, Pittsburgh, PA, March 2009.

GRANTSMANSHIP

2015 (P.I. K.S. Anseth) R01 “Synergistic Effects of Inflammatory and Mechanobiology Signals on Cardiac Valve Disease Progression” (pending) 2015 (P.I. K.S. Anseth) R21 “Dynamic Hydrogel Substrates for Studying the Effects of Stiffness on Fibrosis” (resubmission, 20th percentile) 2014 (P.I. K.S. Anseth) R01 “ Niches to Study VICs and Their Myofibroblast Properties” (not funded) 2014 (P.I. K.S. Anseth) R21 “Dynamic Hydrogel Substrates for Studying the Effects of Stiffness on Fibrosis” (22nd percentile) 2014 AHA Postdoctoral Fellowship (Funded – 8th percentile) 2014 BWF Postdoctoral Enrichment Program Award (Funded) 2013 (resubmission) F32 “Engineered Hydrogels with Reversible Moduli to Probe Myofibroblast Activation” (Funded – 33rd percentile)

PROFESSIONAL DEVELOPMENT

Analytical and Quantitative Light Microscopy course (2015) Marine Biological Laboratory, Woods Hole, MA Preparing for an Engineering Faculty Career course (2014) University of Colorado, Boulder, CO Future Faculty Workshop: Diverse Leaders of Tomorrow (2011) Organized by Professor Timothy Swager, Dedham, MA

TEACHING AND MENTORING EXPERIENCE

Undergraduates Mentored Eric Michael Nehls (University of Colorado, Boulder) 07/2013 – 07/2015 Marilyn and Howard L. Anseth Outstanding Undergraduate Research Award 2014-2015 Outstanding Undergraduate Research Award – Gold Recipient AHA Summer Undergraduate Research Fellow Aakriti Jain (University of California, Berkeley) 01/2011 – 05/2011

High School Students Mentored Laura Fleming (Boulder, CO) 06/2014 – 08/2014

Graduate Student Instructor 08/2008 – 12/2008 Thermodynamics, ChE 141, University of California, Berkeley Instructor: Professor Roya Maboudian

SERVICE AND PROFESSIONAL ASSOCIATIONS Peer Reviewer for Biomacromolecules, Acta Biomaterialia, Macromolecules, ACS Macro Letters Member, American Physical Society, American Chemical Society, Society for Biomaterials, American Institute of Chemical Engineers

SCIENTIFIC OUTREACH

11/2013 – 05/2014 AP Chemistry tutor, Skyline High School, Longmont, CO 01/2013 & 04/2012 Introduction to Polymers for 8th grade, Castro Valley Middle School Organized and taught polymers lesson (with Lauren Baiocchi, teacher) 2009 – 2012 Community in the Classroom volunteer Science demonstrations for 2nd graders at schools in East Bay Area, CA 2009 & 2008 Introduction to Polymers at Rio Mesa High School in Oxnard, CA Designed & led 2 day course 2006 – 2007 Women in Engineering Program Peer Assistance Leader 2005 – 2006 Community Affairs Director, Society of Women Engineers, UT-Austin Organized one day workshop to introduce high school women (over 100 students) to engineering disciplines

JSC Biotechnology Center Campus Box 596 Boulder, CO 80309-0596 Phone: 303-492-3147 Email: [email protected]

October 15, 2015

Dear Faculty Search Committee:

It is my distinct pleasure to write this letter in strongest support of Dr. Adrianne Rosales and her application for a tenure track faculty position in your department. As a brief background, Adrianne joined my research group in July of 2013, after completing an outstanding PhD thesis with Prof. Rachel Segalman at the University of California at Berkeley (supporting letter). In her doctoral research, Adrianne studied the self-assembly of di-block copolymer systems, and completed pioneering work with polypeptoids as one of the blocks. By synthesizing these complex copolymers, Adrianne was able to achieve a rich set of secondary and tertiary structures, which in some ways, resembled biological polymers. Her findings culminated in a series of publications in the highest quality polymer science journals (e.g., Macromolecules, JACS, Soft Matter), and her scholarship and contributions are highly regarded across the material science community. With respect to her postdoctoral research in my group and her proposed research plan, Adrianne brings an outstanding combination of skills that are rare to find in a single individual. She has the unique background of being highly qualified in all aspects of the materials development and characterization, and she is focused on developing and using advanced biomaterials systems to answer important biological questions. Since joining my group, Adrianne has established herself as a leader who combines strong intellectual skills with a deep scientific curiosity. Adrianne is highly regarded for her exceptional polymer chemistry and characterization skills, combined with her excellent ability to articulate and communicate with others. Her current research aims to better understand how fibroblasts, especially heart valve fibroblasts, interact with and respond to mechanical cues from their microenvironments. This has important implications in valve disease progression (and potential reversal), as well as more general classes of fibrotic disease. In particular, Adrianne has developed some highly innovative biomaterial approaches to reversibly change the stiffness of the cellular microenvironment and to monitor the activation of the fibroblasts in real time. She already has her first publications related to this topic (Biomacromolecules, 16, 798-806 (2015)) and she also authored a forwarding looking review on this topic for Nature Materials Reviews that is in press. As a direct reflection of her research ideas and approach, Adrianne has received numerous postdoctoral fellowships, including one from the American Heart Association, an NIH F32, and a Burroughs Wellcome Fund Diversity in Science Award. Beyond her research skills, I would like to add that in my personal interactions with Adrianne, she is driven to excellence in all that she does and is someone who is highly collaborative. Both of these characteristics have served her well in our interdisciplinary laboratory setting. She is also an outstanding communicator, and was recently selected by the University of Washington to participate in its Distinguished Young Scholar Seminar series and as a co-winner of their most outstanding seminar for 2015. She also received a “Best Presentation” award for her talk in the Biomaterials session at the AIChE national meeting in 2014. Adrianne’s ultimate goal is to attain a tenure track faculty position at a major research and teaching university, and I believe that upon completion of her postdoctoral training, Adrianne will be well poised to conduct and lead new directions that are greatly needed for the development of advanced biomaterial systems. Further, Adrianne is a dedicated and thoughtful mentor, and gives of her time and talents to the broader community. As one specific example, Adrianne mentored an undergraduate student, E. Michael Nehls, for two years, including his senior thesis. As part of her mentorship, Adrianne identified a summer fellowship, and helped Michael prepare a competitive proposal that was funded by the American Heart Association. At the culmination of his senior thesis, Adrianne guided Michael through the process of writing a manuscript, and he is first author (as an undergraduate student!) on “Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tether.” This manuscript is under review with the Journal of Materials Chemistry B. Consistent with her exceptional mentorship, Adrianne also put Michael in touch with her former advisor, Ron Zuckerman, so that he could pursue post-baccalaureate research in California at LBNL during a gap year before applying for MD/PhD programs. This is just one specific example, but Adrianne has impacted several undergraduate students at CU and beyond. For example, she volunteered as an AP Chemistry tutor in the Longmont school district, which has a large Hispanic population, and dedicated her time weekly to help these students understand challenging scientific concepts. In my concluding comments, I would like to say that Dr. Adrianne Rosales is outstanding in numerous ways. She is a deep thinker, scientifically curious, committed to high quality work, creative in her research, and devoted to hard work and success. She is also a very generous individual who devotes a significant portion of her time to helping others, in the lab, in the department, and in the community. She is clearly on her way to the path of highest success and fulfillment in a research and teaching career at a top-notch University. I am pleased to forward my highest recommendation in supporting her for application. She is not only an exceptional scientist and person, but someone who can serve as a role model supporting diversity. Please do not hesitate to contact me if I can provide any additional information. Sincerely,

Kristi Anseth Distinguished Professor HHMI Investigator

School of Engineering and Applied Science Department of Bioengineering 240 Skirkanich Hall 210 South 33rd Street Philadelphia, PA 19104-6321 Tel 215.898.8501 Fax 215.573.3155

October 15, 2015

Dear Selection Committee,

I would like to highly recommend Dr. Adrianne Rosales for a tenure-track position in your department. Adrianne is currently a postdoctoral fellow in Professor Kristi Anseth’s laboratory at the University of Colorado. I am very fortunate that Adrianne has been spending some time in my laboratory in the Department of Bioengineering at the University of Pennsylvania as a Visiting Scholar. I’ve gotten to know Adrianne well during this time and it is clear to me that she is intellectually creative, very motivated to succeed as an independent academic, and that she has all of the skills for a successful research career. I have no reservations in making this strong recommendation.

Adrianne has been well recognized for her research, through awards from the University of Washington Distinguished Young Scholar Seminar Series and at the AIChE National Meeting. She was awarded numerous postdoctoral fellowships through the American Heart Association and the National Institutes of Health (F32) and also received a Burroughs Wellcome Fund Postdoctoral Enrichment Program Award that allows her to travel and complete independent research. As a graduate student she received a competitive National Science Foundation Graduate Fellowship and a Chancellor’s Fellowship at UC- Berkeley. These examples speak to the high quality of work that Adrianne has completed during her PhD and postdoc studies.

During her PhD, Adrianne worked with Professor Rachel Segalman on the development of polypeptoids and during her work as a postdoc with Professor Kristi Anseth she has worked on the design of materials with dynamic mechanical properties. Rachel and Kristi can explain in more depth Adrianne’s contribution to her work in their labs, but it is clear that she has been productive with 10 publications in journals such as Nature Review Materials, Soft Matter, JACS, and Macromolecules. These are all important journals in the field.

I’m very excited about the work that Adrianne has been doing with my lab. She is particularly interested in materials such as hydrogels that have dynamic properties, such as changing mechanics. These are quite useful for probing cell behavior in response to changing mechanical properties (e.g., fibrosis). My lab has been working on self-assembled hydrogels that are built from modifications with guest-host pairs (e.g., adamantane-cyclodextrin) that form inclusion complexes that enable the formation of viscoelastic hydrogels. Adrianne introduced the concept of using azobenzene as the guest molecule, due to its ability to complex with cyclodextrin. Since azobenzene undergoes a cis-trans conformational change with light exposure, she was able to produced hydrogels that had reversible complex formation, which led to materials with changing properties. This is an interesting advance in the field and a unique material system. She is currently working to understand how these dynamic changes influence the behavior of interacting cells (atop and within hydrogels). We plan to submit a manuscript on this work within the next few months. In addition to this study, Adrianne has been fantastic about working with other students and postdocs in my lab on projects related to stimuli-responsive assemblies and her synthetic chemistry background has been invaluable in these projects.

I have discussed Adrianne’s research proposal with her and it is clear that she has formulated a clear vision for her future laboratory, related to the introduction of complexity into material design. Her laboratory will span fundamental polymer studies to understand such phenomena to the application of the substrates to biological questions. She is targeting a number of very interesting and timely applications, such as to understand cell behavior related to cardiac muscle fibrosis after injury and to the

understanding of cell adhesion and integrin binding with engineered peptides. These applications will exploit that she has over material complexity and I do not think she will have trouble securing funding in these areas.

Adrianne has presented her work over the last few years at the Society for Biomaterials, the American Chemical Society, the American Institute of Chemical Engineers Annual Meeting, and various Gordon Research Conferences. Based on her presentations during lab meeting and her presentations at research conferences, it is clear that Adrianne is able to present and motivate her research findings in a clear manner. Her success in obtaining research fellowships speaks to her ability to convey her ideas in a grant proposal. She has also reviewed manuscripts for numerous journals such as Biomacromolecules, Macromolecules, and ACS Macro Letters.

Beyond these research skills, Adrianne is well qualified to undertake the teaching and mentoring that is needed in an academic position. She has already mentored numerous undergraduate and high school students and performed numerous activities related to science outreach. These experiences and her other past experiences as a teaching assistant will provide her with a strong background for teaching and mentoring as a faculty member.

Finally, Adrianne is a very personable member of the laboratory and is active in research discussions and collaborations throughout my laboratory and beyond. Ultimately, I believe she will be very successful in an independent academic career and I hope that you give her application great consideration.

Sincerely,

Jason Burdick, Ph.D. Professor Department of Bioengineering University of Pennsylvania

UNIVERSITY OF CALIFORNIA, Santa Barbara

BERKELEY • DAVIS • IRVINE • LOS ANGELES • MERCED • RIVERSIDE • SAN DIEGO • SAN FRANCISCO SANTA BARBARA • SANTA CRUZ

Professor Rachel A. Segalman Tel: 805-893-3709 E. N. Kramer Professor, Departments of Chemical Engineering and Materials Chair, Department of Chemical Engineering e-mail: [email protected] University of California Santa Barbara, CA 93117-5080

October 20, 2015

Recommendation for Adrianne Rosales for a Tenure track faculty position at the University of Texas

It is my great pleasure to recommend Adrianne Rosales for a faculty position at the University of Texas (our mutual alma mater!). While completing her doctoral thesis, Adrianne was an invaluable member of my research group studying the self-assembly and properties of bioinspired polymer systems. Not only was her grasp of scientific fundamentals and motivation for research superb, Adrianne stood out as the most scientifically articulate, well read, and communicative member of my research group past or present. As a result, her research both at Berkeley and during her postdoc at Colorado, has been characterized by deep and complex insights delivered with startling clarity. This unusual combination of talents contributes to Adrianne’s success as a young independent scientist and mentor and also portends her future as a formidable faculty member.

Simple diblock copolymers in solution have been the subject of much interest and their ability to form micelles and vesicles is now classic. Adrianne’s work as a doctoral student focused on much more complicated polymers, which are capable of encompassing a rich set of secondary and tertiary structures and, in some ways, resemble biological polymers. Co-advised by Dr. Ron Zuckermann (Molecular Foundry, Lawrence Berkeley National Labs), Adrianne studied the polymer physics of polypeptoids (N-subsitituted polyglycine). The monomer sequence in these peptide mimics can be controlled as it is in synthetic polypeptides, but the intra and intermolecular interactions are much simpler than in biological polymers and can be programmed via molecular design. As a result, Adrianne was able to directly explore the role of monomer sequence and chain shape on self-assembly. First, she showed that monomer sequence has a profound effect on a polymer’s ability to crystallize (Macromolecules 2010). In some ways, the use of co-monomers to control crystallization has been well known since the days of Flory, but is particularly important as one attempts to self-assemble functional polymers in which frequently crystallization supersedes controlled self-assembly. Once the melting temperature can be controlled, other design parameters can be implemented to allow for directed self-assembly, for example in diblock copolymers (Macromolecules, 2012).

Adrianne has also been very interested in understanding the solution chain shape of these molecules, particularly when charges are present as this presents an intermediate scientific space between understanding of polyelectrolyte chain behavior and protein crystallography. In these three publications (Macromolecules 2012, JACS 2010 and Soft Matter, 2012), Adrianne collaborated very closely with theorists (particularly Andrey Dobornin) to understand the specific fundamental interactions in her polymers. In her years at Berkeley, she initiated what is now a large collaboration with Dr. Zuckermann. In doing so, Adrianne had to learn to translate between the based language of my group and the strongly biological/chemistry centered culture of Ron’s group. Her success speaks strongly to their strong scientific abilities and diplomatic skills. Furthermore, Adrianne wass possibly the most driven member of my group at that time. She reads the literature voraciously and incorporates all of these ideas into new experiments to be tried.

For the last two years, Adrianne has been a postdoc with the Anseth group at Colorado working on the synthesis of hydrogels with tunable elastic properties and drug delivery capabilities to mimic extracellular matrices. While I am sure that Professor Anseth’s letter will cover the details of Adrianne’s recent research accomplishments, I have watched from afar with great interest as Adrianne has broadened her scientific insight to the interface with biology and also developed the independence and self-confidence to ready herself for an academic career. In this time not only has she authored (or co-authored) three publications, her work and ability clearly articulate new, revolutionary ideas have already started to win awards. She is a recent recipient of two nationally competitive postdoctoral fellowships (from the National Institutes of Health and the Burroughs Wellcome Fund). Further, Adrianne was a co-winner of the Best Distinguished Young Scholar Seminar at the University of Washington (a program with a history of identifying promising future faculty candidates). These awards speak to Adrianne’s ability to identify new research areas that bridge , biomaterials, and chemical engineering. This ability to clearly and articulately identify important problems at the interfaces of communities is critical in today’s competitive funding environment and Adrianne’s early success at these awards is an important indicator of an exciting trajectory.

Adrianne’s communication skills and genuine desire for scientific interaction with others portend a successful career as a researcher, mentor, and teacher. It should be mentioned that Adrianne is a brilliant, Hispanic, female scientist with the kind of articulate, approachable demeanor that I am sure will result in her being a role model for a more diverse community of scientists to come. During her time in my group, Adrianne mentored several undergraduates, but more importantly, she helped build a very strong sense of teamwork amongst the graduate students in my lab. I believe she mentored and edited every NSF graduate fellowship and qualifying exam proposal generated by a member of my group during her time at Berkeley and I attribute much of my student’s success to her. She has a unique ability to both be deeply knowledgeable and encourage independence in those that work with and around her. In comparison to other recent graduates of my group, Adrianne’s grasp of scientific fundamentals is easily on par with the very best. Further, her ability to mentor students towards success and independence is on par with Bradley Olsen (MIT) while her ability to collaborate with other scientists and translate between fields of science is similar to Shannon Yee (Georgia Tech). I sincerely enjoyed my four years of working with Adrianne and hope that you she brings as much excitement to the broader community and your department in years to come.

Sincerely,

Rachel A. Segalman