Makings of a Multibagger an Analysis of the Best Performing Stocks Over the Past 5 Years
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4C Buried Secrets
R-0048 a reporter at laRgE bURiEd sEcrets How an Israeli billionaire wrested control of one of Africa’s biggest prizes. bY paTRick radden keefE 50 THE NEW YORKER, JULY 8 & 15, 2013 TNY—2013_07_08&15—PAGE 50—133SC.—Live art r23707—CritiCAL PHOTOGRAPH TO BE WATCHED THROUGHOUT THE ENTIRE PRESS run—pLEASE PULL KODAK APPROVAL PROOF F0R PRESS COLOR GUID- ANCE 4C ne of the world’s largest known de- As wealthy countries confront the posits of untapped iron ore is buried prospect of rapidly depleting natural re- insideO a great, forested mountain range in sources, they are turning, increasingly, the tiny West African republic of Guinea. to Africa, where oil and minerals worth In the country’s southeast highlands, far trillions of dollars remain trapped in the from any city or major roads, the Siman- ground. By one estimate, the continent dou Mountains stretch for seventy miles, holds thirty per cent of the world’s min- looming over the jungle floor like a giant eral reserves. Paul Collier, who runs the dinosaur spine. Some of the peaks have Center for the Study of African Econo- nicknames that were bestowed by geolo- mies, at Oxford, has suggested that “a gists and miners who have worked in the new scramble for Africa” is under way. area; one is Iron Maiden, another Metal- Bilateral trade between China and Af- lica. Iron ore is the raw material that, once rica, which in 2000 stood at ten billion smelted, becomes steel, and the ore at Si- dollars, is projected to top two hundred mandou is unusually rich, meaning that billion dollars this year. -
Development of Swiss Biotechnology Beyond the Biopharmaceutical Sector in Memoriam Prof
BUILDING BRIDGES BETWEEN BIOTECHNOLOGY AND CHEMISTRY – IN MEMORIAM ORESTE GHISALBA CHIMIA 2020, 74, No. 5 345 doi:10.2533/chimia.2020.345 Chimia 74 (2020) 345–359 © H.P. Meyer and O. Werbitzky Development of Swiss Biotechnology Beyond the Biopharmaceutical Sector In memoriam Prof. Dr. Oreste Ghisalba (1946–2018) Hans-Peter Meyera* and Oleg Werbitzkyb Abstract: Although diverse, the potential business opportunities for biotechnology outside the biopharmaceutical market are very large. White biotechnology can offer sustainable operations and products, while investments tend to be lower than those in red biotechnology. But a number of bottlenecks and roadblocks in Switzerland must be removed to realise the full potential of white biotechnology. This was also the point of view of Oreste Ghisalba, who wanted to be part of a new initiative to facilitate the creation of additional business, new pro- cesses and new products. This initiative requires the identification and the use of synergies and a much better cooperation between academia and industry through targeted networking. Unfortunately, we must carry on with this task without Oreste, whom we will miss for his deep knowledge and friendship. Keywords: Bio-based · Fine chemicals · Industrial biotechnology · Swiss economy · White biotechnology Hans-Peter Meyer holds a PhD in micro- venture partners and Managing Director of NC Health Sciences biology from the University of Fribourg since 2015. (Switzerland). He spent three years post- graduate and postdoc studies at the STFI 1. A Short History of the Swiss Biotechnology Industry in Stockholm (Sweden), the University The Swiss pharmaceutical and chemical industries have been of Pennsylvania and Lehigh University in responsible for almost half of the country’s exports for many years the USA. -
A CB1 Receptor Antagonist As a Direct Interactional Partner for Μ- and Δ-Opioid Receptor
Rimonabant: a CB1 receptor antagonist as a direct interactional partner for μ- and δ-opioid receptor Ph.D. thesis Ferenc Zádor Supervisor: Dr. Sándor Benyhe Institute of Biochemistry Biological Research Center of the Hungarian Academy of Sciences Szeged, Hungary 2014 TABLE OF CONTENTS LIST OF PUBLICATIONS ...................................................................................................... i LIST OF ABBREVIATIONS .................................................................................................. ii 1 REVIEW OF THE LITERATURE ................................................................................. 1 1.1 G-protein coupled receptors (GPCR) .............................................................................. 1 1.1.1 About GPCRs in general ................................................................................................................ 1 1.1.2 The structure of GPCRs ................................................................................................................. 3 1.1.3 The spectrum of GPCR ligand efficacy and constitutive activity of GPCRs ................................. 3 1.1.4 GPCR signaling: the G-protein activation/deactivation cycle ....................................................... 4 1.1.5 The complexity of GPCR signaling ............................................................................................... 6 1.2 Opioids and cannabinoids and their endogenous systems ............................................. 7 1.2.1 Opium poppy and the -
NASDAQ Stock Market
Nasdaq Stock Market Friday, December 28, 2018 Name Symbol Close 1st Constitution Bancorp FCCY 19.75 1st Source SRCE 40.25 2U TWOU 48.31 21st Century Fox Cl A FOXA 47.97 21st Century Fox Cl B FOX 47.62 21Vianet Group ADR VNET 8.63 51job ADR JOBS 61.7 111 ADR YI 6.05 360 Finance ADR QFIN 15.74 1347 Property Insurance Holdings PIH 4.05 1-800-FLOWERS.COM Cl A FLWS 11.92 AAON AAON 34.85 Abiomed ABMD 318.17 Acacia Communications ACIA 37.69 Acacia Research - Acacia ACTG 3 Technologies Acadia Healthcare ACHC 25.56 ACADIA Pharmaceuticals ACAD 15.65 Acceleron Pharma XLRN 44.13 Access National ANCX 21.31 Accuray ARAY 3.45 AcelRx Pharmaceuticals ACRX 2.34 Aceto ACET 0.82 Achaogen AKAO 1.31 Achillion Pharmaceuticals ACHN 1.48 AC Immune ACIU 9.78 ACI Worldwide ACIW 27.25 Aclaris Therapeutics ACRS 7.31 ACM Research Cl A ACMR 10.47 Acorda Therapeutics ACOR 14.98 Activision Blizzard ATVI 46.8 Adamas Pharmaceuticals ADMS 8.45 Adaptimmune Therapeutics ADR ADAP 5.15 Addus HomeCare ADUS 67.27 ADDvantage Technologies Group AEY 1.43 Adobe ADBE 223.13 Adtran ADTN 10.82 Aduro Biotech ADRO 2.65 Advanced Emissions Solutions ADES 10.07 Advanced Energy Industries AEIS 42.71 Advanced Micro Devices AMD 17.82 Advaxis ADXS 0.19 Adverum Biotechnologies ADVM 3.2 Aegion AEGN 16.24 Aeglea BioTherapeutics AGLE 7.67 Aemetis AMTX 0.57 Aerie Pharmaceuticals AERI 35.52 AeroVironment AVAV 67.57 Aevi Genomic Medicine GNMX 0.67 Affimed AFMD 3.11 Agile Therapeutics AGRX 0.61 Agilysys AGYS 14.59 Agios Pharmaceuticals AGIO 45.3 AGNC Investment AGNC 17.73 AgroFresh Solutions AGFS 3.85 -
Israel and the Alien Tort Statute
Summer 2014 No.54 JTheUSTICE magazine of the International Association of Jewish Lawyers and Jurists In this issue The International Court of Justice Adjudicating the Arab-Israel Disputes? Boycotts, Divestment, Sanctions and the Law Israel and the Alien Tort Statute Corporations and Human Rights Zivotofsky v. Kerry - A Historical Constitutional Battle Preachers of Hate and Freedom of Expression UNRWA Panel at UN IAJLJ Activities The International Association of Jewish Lawyers and Jurists Honorary President: Hadassa Ben-Itto, Judge (Ret.) (Israel) Life time Member: Irwin Cotler, Prof. (Canada) Honorary Vice Presidents: Joseph Roubache (France) Oreste Bisazza Terracini, Dr. (Italy) Executive Committee: Board of Governors: President: Irit Kohn (Israel) Irit Kohn (Israel) Haim Klugman (Israel) Avraham (Avi) D. Doron (Israel) Deputy President: Meir Rosenne, Dr. (Israel) Haim Klugman (Israel) Mirella M. Bamberger (Israel) Alyza D. Lewin (USA) Vice President and Treasurer: Marcos Arnoldo Grabivker, Judge (Argentina) Avraham (Avi) D. Doron (Israel) Maurizio Ruben (Italy) Alex Hertman (Israel) Vice President and Coordinator with Amos Shapira, Prof. (Israel) International Organizations: Avishai Sapir (Israel) Meir Rosenne, Dr. (Israel) David Pardes (Belgium) Dov Shefi, Brig. (Ret.) (Israel) Vice President and Secretary General: Edna Bekenstein, Judge (Ret.) (Israel) Mirella M. Bamberger (Israel) Edna Kaplan-Hagler, Judge (Ret.) Dr. (Israel) Efraim (Efi) Chalamish, Dr. (USA) Vice Presidents: Ethia Simha (Israel) Alyza D. Lewin (USA) Jeremy D. Margolis (USA) Marcos Arnoldo Grabivker, Judge (Argentina) Jimena Bronfman (Chile) Maurizio Ruben (Italy) Jonathan Lux (UK) Lipa Meir, Dr. (Israel) Academic Adviser: Mala Tabory, Dr. (Israel) Yaffa Zilbershats, Prof. (Israel) Maria Canals De-Cediel, Dr. (Switzerland) Meir Linzen (Israel) Representatives to the U.N. -
List of Section 13F Securities
List of Section 13F Securities 1st Quarter FY 2004 Copyright (c) 2004 American Bankers Association. CUSIP Numbers and descriptions are used with permission by Standard & Poors CUSIP Service Bureau, a division of The McGraw-Hill Companies, Inc. All rights reserved. No redistribution without permission from Standard & Poors CUSIP Service Bureau. Standard & Poors CUSIP Service Bureau does not guarantee the accuracy or completeness of the CUSIP Numbers and standard descriptions included herein and neither the American Bankers Association nor Standard & Poor's CUSIP Service Bureau shall be responsible for any errors, omissions or damages arising out of the use of such information. U.S. Securities and Exchange Commission OFFICIAL LIST OF SECTION 13(f) SECURITIES USER INFORMATION SHEET General This list of “Section 13(f) securities” as defined by Rule 13f-1(c) [17 CFR 240.13f-1(c)] is made available to the public pursuant to Section13 (f) (3) of the Securities Exchange Act of 1934 [15 USC 78m(f) (3)]. It is made available for use in the preparation of reports filed with the Securities and Exhange Commission pursuant to Rule 13f-1 [17 CFR 240.13f-1] under Section 13(f) of the Securities Exchange Act of 1934. An updated list is published on a quarterly basis. This list is current as of March 15, 2004, and may be relied on by institutional investment managers filing Form 13F reports for the calendar quarter ending March 31, 2004. Institutional investment managers should report holdings--number of shares and fair market value--as of the last day of the calendar quarter as required by Section 13(f)(1) and Rule 13f-1 thereunder. -
INSIGHT CASE STUDY Insight Confidential
INSIGHT CASE STUDY Insight Confidential Since 1988, Insight has evolved from a technology start-up to a global IT player; from a private, home-based business to a publicly traded Fortune 500 corporation. In addition, Insight has grown through a number of acquisitions, bringing dynamic new cultures into the Insight fold. How do we drive cohesion and strengthen our One Team to perform more consistently, capture market share and increase our share of every dollar we sell? Over the years, Insight has undergone an aggressive evolution of its strategy as the company grew from its roots as a low-cost, high availability product provider to offering a value proposition few of its competitors could claim: A global information technology provider of hardware, software and service solutions to business and government clients. When asked about the evolution of the business, Insight co-founder Tim Crown said, “My brother Eric and I have always described the business as a series of strategic decisions. These led us from being a hard drive only company advertising in magazines on an inbound basis, to a multi-product cataloger, to a business to business product reseller with outbound sales, to an IT service provider.” Around the same time Insight was founded, a number of competitors were also established and in much the same way. Through the years, these competitors have also evolved their strategies and focus areas to remain successful in a highly dynamic and competitive IT environment. These efforts have had varying degrees of success. In 2011, the Insight senior leadership team knew the business had the right value proposition to grow to a new level of achievement. -
Yuuna and the Haunted Hot Springs Premiering on Crunchyroll This July!
FOR IMMEDIATE RELEASE June 20, 2018 Yuuna and the Haunted Hot Springs Premiering on Crunchyroll This July! ©TADAHIRO MIURA/SHUEISHA, YURAGISONOYUNASAN COMMITTEE A slightly sexy hot springs and ghost love comedy! SANTA MONICA, CA (June 20, 2018) – On the Aniplex Live! show on Facebook, Aniplex of America announced that the hilarious and sexy love comedy, Yuuna and the Haunted Hot Springs, will be premiering on Crunchyroll, the world’s largest destination for anime and manga in the world, this summer. Based on a popular manga by Tadahiro Miura and published by SHUEISHA, the supernatural series centers around a psychic Kogarashi Fuyuzora who is curiously described as being very “hands on.” Through a series of unfortunate events, he finds himself in need of a cheap room to rent and finds one at a hot springs inn with some ghostly residents called the Yuragi Inn. Voiced by popular voice actor Yuki Ono from GRANBLUE FANTASY The Animation and VALVRAVE the Liberator, Kogarashi encounters a voluptuous ghost named Yuuna, voiced by newcomer Miyuri Shimabukuro in her breakout role. Other cast members include Eri Suzuki (Monster Strike the Animation, Nanana’s Buried Treasure), Rie Takahashi (Fate/Grand Order – First Order-, KonoSuba –God’s blessing on this wonderful world!), Ai Kakuma (ALDNOAH.ZERO, The Asterisk War), Mikako Komatsu, (Eromanga Sensei, Nisekoi), and Anzu Haruno from BLEND-S. The series will be directed by Tsuyoshi Nagasawa (Kyo no Gononi, Nyaruko: Crawling With Love!) with character design by Kyoko Taketani (Pókemon the Movie: Black –Victini and Reshiram, Oreca Battle). Animation production will be handled by XEBEC (Love Hina, BanG Dream!, To Love-Ru) featuring music by Tomoki Kikuya of Nisekoi, BLEND- S, and Eromanga Sensei fame. -
Trademarks, Triggers and Online Search Working Paper
Trademarks, Triggers and Online Search Working paper Stefan Bechtold∗ and Catherine Tuckery May 18, 2013 Abstract Internet search engines display advertisements along with search results, providing them with a major source of revenue. The display of ads is triggered by the use of keywords, which are found in the searches performed by search engine users. The fact that advertisers can buy a keyword that contains a trademark they do not own has caused controversy worldwide. To explore the actual effects of trademark and keyword advertising policies, we exploit a natural experiment in Europe. Following a decision by the Court of Justice of the European Union, Google relaxed its AdWords policy in continental Europe in September 2010. After the policy change, Google allowed advertisers to select a third party's trademark as a keyword to trigger the display of ads. We use click-stream data from European Internet users to explore the impact this policy change had on browsing behavior. Based on a data set of 5.38 million web site visits before and after the policy change, we find little average change. However, we present evidence that this lack of average effect stems from an aggregation of two opposing effects. While navigational searches are less likely to lead to the trademark owner's website, non-navigational searches are more likely to lead to the trademark owner's website after the policy change. The effect of changing keyword advertising policies varies with the purpose of the consumers using the trademark. It is the resulting tradeoffs, rather than consumer confusion, on which the keyword advertising debate should focus. -
Global Equity Fund Description Plan 3S DCP & JRA MICROSOFT CORP
Global Equity Fund June 30, 2020 Note: Numbers may not always add up due to rounding. % Invested For Each Plan Description Plan 3s DCP & JRA MICROSOFT CORP 2.5289% 2.5289% APPLE INC 2.4756% 2.4756% AMAZON COM INC 1.9411% 1.9411% FACEBOOK CLASS A INC 0.9048% 0.9048% ALPHABET INC CLASS A 0.7033% 0.7033% ALPHABET INC CLASS C 0.6978% 0.6978% ALIBABA GROUP HOLDING ADR REPRESEN 0.6724% 0.6724% JOHNSON & JOHNSON 0.6151% 0.6151% TENCENT HOLDINGS LTD 0.6124% 0.6124% BERKSHIRE HATHAWAY INC CLASS B 0.5765% 0.5765% NESTLE SA 0.5428% 0.5428% VISA INC CLASS A 0.5408% 0.5408% PROCTER & GAMBLE 0.4838% 0.4838% JPMORGAN CHASE & CO 0.4730% 0.4730% UNITEDHEALTH GROUP INC 0.4619% 0.4619% ISHARES RUSSELL 3000 ETF 0.4525% 0.4525% HOME DEPOT INC 0.4463% 0.4463% TAIWAN SEMICONDUCTOR MANUFACTURING 0.4337% 0.4337% MASTERCARD INC CLASS A 0.4325% 0.4325% INTEL CORPORATION CORP 0.4207% 0.4207% SHORT-TERM INVESTMENT FUND 0.4158% 0.4158% ROCHE HOLDING PAR AG 0.4017% 0.4017% VERIZON COMMUNICATIONS INC 0.3792% 0.3792% NVIDIA CORP 0.3721% 0.3721% AT&T INC 0.3583% 0.3583% SAMSUNG ELECTRONICS LTD 0.3483% 0.3483% ADOBE INC 0.3473% 0.3473% PAYPAL HOLDINGS INC 0.3395% 0.3395% WALT DISNEY 0.3342% 0.3342% CISCO SYSTEMS INC 0.3283% 0.3283% MERCK & CO INC 0.3242% 0.3242% NETFLIX INC 0.3213% 0.3213% EXXON MOBIL CORP 0.3138% 0.3138% NOVARTIS AG 0.3084% 0.3084% BANK OF AMERICA CORP 0.3046% 0.3046% PEPSICO INC 0.3036% 0.3036% PFIZER INC 0.3020% 0.3020% COMCAST CORP CLASS A 0.2929% 0.2929% COCA-COLA 0.2872% 0.2872% ABBVIE INC 0.2870% 0.2870% CHEVRON CORP 0.2767% 0.2767% WALMART INC 0.2767% -
… … Mushi Production
1948 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 … Mushi Production (ancien) † / 1961 – 1973 Tezuka Productions / 1968 – Group TAC † / 1968 – 2010 Satelight / 1995 – GoHands / 2008 – 8-Bit / 2008 – Diomédéa / 2005 – Sunrise / 1971 – Deen / 1975 – Studio Kuma / 1977 – Studio Matrix / 2000 – Studio Dub / 1983 – Studio Takuranke / 1987 – Studio Gazelle / 1993 – Bones / 1998 – Kinema Citrus / 2008 – Lay-Duce / 2013 – Manglobe † / 2002 – 2015 Studio Bridge / 2007 – Bandai Namco Pictures / 2015 – Madhouse / 1972 – Triangle Staff † / 1987 – 2000 Studio Palm / 1999 – A.C.G.T. / 2000 – Nomad / 2003 – Studio Chizu / 2011 – MAPPA / 2011 – Studio Uni / 1972 – Tsuchida Pro † / 1976 – 1986 Studio Hibari / 1979 – Larx Entertainment / 2006 – Project No.9 / 2009 – Lerche / 2011 – Studio Fantasia / 1983 – 2016 Chaos Project / 1995 – Studio Comet / 1986 – Nakamura Production / 1974 – Shaft / 1975 – Studio Live / 1976 – Mushi Production (nouveau) / 1977 – A.P.P.P. / 1984 – Imagin / 1992 – Kyoto Animation / 1985 – Animation Do / 2000 – Ordet / 2007 – Mushi production 1948 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 … 1948 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 … Tatsunoko Production / 1962 – Ashi Production >> Production Reed / 1975 – Studio Plum / 1996/97 (?) – Actas / 1998 – I Move (アイムーヴ) / 2000 – Kaname Prod. -
Selection and Characterization of Amyloid-Β1-42 Binding D-Enantiomeric Peptides for Potential Therapeutic Intervention of Alzheimer´S Disease
Selection and characterization of Amyloid-β1-42 binding D-enantiomeric peptides for potential therapeutic intervention of Alzheimer´s disease Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf vorgelegt von Stephan Rudolph aus Dessau Düsseldorf, April 2015 Die vorliegende Arbeit wurde in der Zeit von April 2011 bis Februar 2015 am Institut für Physikalische Biologie der Heinrich-Heine-Universität Düsseldorf unter der Leitung von Prof. Dr. Dieter Willbold angefertigt. Gedruckt mit der Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf Referent: Prof. Dr. Dieter Willbold Koreferent: Prof. Dr. Georg Groth Tag der mündlichen Prüfung: „Die Dummheiten wechseln, und die Dummheit bleibt.“ (Erich Kästner) „Die dunkelste Stunde ist die vor Sonnenaufgang.“ (chinesisches Sprichwort) Für Tante Elli Index Index Index I - IV 1. Introduction 1 1.1 Alzheimer´s disease (AD) – an overview .................................................... 1 1.1.1 General information ............................................................................. 1 1.1.2 History and pathology of AD ................................................................ 3 1.1.3 The amyloid precursor protein (APP) ................................................... 4 1.1.4 From APP to Aβ ................................................................................... 7 1.1.5 The physiological role of Aβ and Tau .................................................