Journal of the Medical Society of the Republic of Srpska Časopis Društva Doktora Medicine Republike Srpske Dental Anxiety in C

Total Page:16

File Type:pdf, Size:1020Kb

Journal of the Medical Society of the Republic of Srpska Časopis Društva Doktora Medicine Republike Srpske Dental Anxiety in C 46 Journal of the Medical Society of the Republic of Srpska Časopis Društva doktora medicine Republike Srpske Vol. 46 • No 1 • April 2015. ORIGINAL ARTICLE Medical Society of the Republic of Srpska Dental Anxiety in Children Aged 6-15 years LJ. MARKOVIĆ ĐURIĆ, A. KOS-DRAGIČEVIĆ, M. BEKTAŠEVIĆ Godina: 46. • Broj 1 • April 2015. Časopis Društva doktora medicine Republike Srpske ORIGINAL ARTICLE Distribution of Clinically Relevant Erythrocyte Antigens among Blood Donors of the Republic of Srpska G. GUZIJAN, J. BOJANIĆ, D. JOJIĆ, B. JUKIĆ, S. MITROVIĆ, V. ĆEJIĆ ORIGINAL ARTICLE Prevalence of HIV and other Sexually Transmitted Infections among Female Sex Workers in Bosnia and Herzegovina J. BOJANIĆ, G. GUZIJAN, LJ. BOJANIĆ, LJ. JANDRIĆ, N. RODIĆ VUKMIR, J. AĆIMOVIĆ ORIGINAL ARTICLE Influence of Age and Gender on Asymptomatic Carotid Disease V. ĐAJIĆ, S. MILJKOVIĆ, LJ. PRERADOVIĆ, Z. VUJKOVIĆ, D. RAČIĆ ORIGINAL ARTICLE Attitudes and Opinions of Health Care Students of Medical Faculty in Banja Luka about Study Program and Nursing as a Profession D. JOVIĆ, D. KNEŽEVIĆ, M. SKROBIĆ, A. MATAVULJ, J. VUČKOVIĆ PROFESSIONAL PAPER Omphalocele and Gastroshisis: a 14-year Study M. RAKOVIĆ, Z. MAKSIMOVIĆ, D. DANELIŠEN, D. PAŠALIĆ PROFESSIONAL PAPER Quality of Life of Schizophrenic Patients with or without Depot Neuroleptics I. SIMIĆ MEDOJEVIĆ, M. BURGIĆ-RADMANOVIĆ REVIEW ARTICLE Low-pressure and Gasless Laparascopy in Abdominal Surgery Š. HASUKIĆ CASE REPORT Giant Mucinous Ovarian Cystadenocarcinoma F. KONJIĆ, Z. RIFATBEGOVIĆ, M. PIRIĆ, Š. HASUKIĆ BOOK REVIEW Clinical anatomy www.scriptamedica.com Scripta Medica Vol. 46 • No 1 • April 2015. • www.scriptamedica.com 3 Scripta Medica (Banja Luka) Journal of the Medical Society of the Republic of Srpska EDITORIAL BOARD International Advisory Board Milorad Mitković, Niš, Srbija Marko Bumbaširević, Beograd,Srbija Editor–in- chief Dragan Micić, Beograd, Srbija Đorđe Radak, Beograd, Srbija Predrag Grubor Dušan Stefanović, Beograd, Srbija Branislav Antić, Beograd, Srbija Vinka Vukotić, Beograd, Srbija Senior Editors Nebojša Bojanić, Beograd, Srbija Milka Mavija Miodrag Ostojić, Beograd, Srbija Snježana Milićević Bosiljka Vujisić Tešić, Beograd,Srbija Slavica Jandrić Milorad Žikić, Novi Sad, Srbija Tamara Kovačević Preradović Branislav Bobić, Novi Sad, Srbija Siniša Ristić Beatrice Amann Vesti, Cirih, Švicarska Franz Wolfgang Amann, Cirih, Švicarska Luigi Meccariello, Siena, Italija Members Vanda Marković Peković Web site Editor: Čedomir Radulović Šefik Hasukić Siniša Maksimović Technical secretary : Biljana Radišić Mirza Biščević English editor: Marina Novković Layout: Dragana Pupac Design: CGM Design, Banja Luka PUBLISHING COUNCIL Publishers: Društvo doktora medicine RS Medicinski fakultet, Banja Luka Printed by: Grafix s. p., Banja Luka Co-Presidents Siniša Miljković, PhD ISSN 0350-8218 Milan Skrobić, PhD Printig: 1 000 Members Zoran Vujković, PhD Goran Spasojević, PhD Radoslav Gajanin, PhD Nikola Gavrić, PhD Duško Vasić, PhD Milenko Krneta, M.D Copyright © Društvo doktora medicine Republike This issue of the SM is printed on acid-free paper Srpske Scripta Medica 4 Vol. 45 • No 1 • May 2014. • www.scriptamedica.com Content 7 ORIGINAL ARTICLE Epidemiološke karakteristike meningitisa izazvanog Dental Anxiety in Children Aged 6-15 years virusom mumps-a u toku epidemije u Republici Dentalna anksioznost kod djece uzrasta 6-15 Srpskoj godina T. ROGANOVIĆ, Z. KEZIĆ, J. BOJANIĆ, B. MIJOVIĆ, LJ. JANDRIĆ, N. RODIĆ- LJ. MARKOVIĆ ĐURIĆ, A. KOS-DRAGIČEVIĆ, M. BEKTAŠEVIĆ VUKMI 12 ORIGINAL ARTICLE 43 ORIGINAL ARTICLE Oral Health in Children with Intellectual Disabilities in Influence of Age and Gender on Asymptomatic Banja Luka Municipality Carotid Disease Oralno zdravlje djece ometene u mentalnom razvoju Uticaj životnog doba i pola na karotidnu ˝ na području opštine Banja Luka asimptomatsku bolest S. ILIĆ, R. KNEŽEVIĆ V. ĐAJIĆ, S. MILJKOVIĆ, LJ. PRERADOVIĆ, Z. VUJKOVIĆ, D. RAČIĆ 18 ORIGINAL ARTICLE 49 ORIGINAL ARTICLE Distribution of Clinically Relevant Erythrocyte Attitudes and Opinions of Health Care Students Antigens among Blood Donors of the Republic of of Medical Faculty in Banja Luka about Study Srpska Program and Nursing as a Profession Distribucija klinički značajnih eritrocitnih antigena u Stavovi i mišljenja studenata zdravstvene njege populaciji davalaca krvi Republike Srpske Medicinskog fakulteta u Banjoj Luci o studijskom G. GUZIJAN, J. BOJANIĆ, D. JOJIĆ, B. JUKIĆ, S. MITROVIĆ, V. ĆEJIĆ programu i sestrinstvu kao profesiji D. JOVIĆ, D. KNEŽEVIĆ, M. SKROBIĆ, A. MATAVULJ, J. VUČKOVIĆ 24 ORIGINAL ARTICLE Disturbances of Bone and Mineral Metabolism in 55 PROFESSIONAL PAPER Patients on Hemodialysis Omphalocele and gastroshisis: a 14-year study Poremećaji koštano-mineralnog metabolizma kod Omfalocele i gastroshize: 14-godišnja studija hemodijaliznih pacijenata M. RAKOVIĆ, Z. MAKSIMOVIĆ, D. DANELIŠEN, D. PAŠALIĆ B. GAŠIĆ, D. ZRNIĆ-MIĆIĆ, S. MILJKOVIĆ 60 PROFESSIONAL PAPER 29 ORIGINAL ARTICLE Quality of Life of Schizophrenic Patients with or Prevalence of HIV and other Sexually Transmitted without Depot Neuroleptics Infections among Female Sex Workers in Bosnia Kvalitet života shizofrenih pacijenata sa i bez depo and Herzegovina preparata neuroleptika Prevalencija HIV-a i drugih polno prenosivih infekcija I. SIMIĆ MEDOJEVIĆ, M. BURGIĆ-RADMANOVIĆ među seksualnim radnicama u Bosni i Hercegovini J. BOJANIĆ, G. GUZIJAN, LJ. BOJANIĆ, LJ. JANDRIĆ, N. RODIĆ VUKMIR, J. 66 REVIEW ARTICLE AĆIMOVIĆ Low-pressure and Gasless Laparascopy in Abdominal Surgery 37 ORIGINAL ARTICLE Laparoskopija sa niskim intrabadominalnim Epidemiological Characteristics of Meningitis pritiskom i bezplinska laparoskopija u abdominalnoj Caused by Mumps virus during the epidemic In the hirurgiji Republic Of Srpska Š. HASUKIĆ Scripta Medica Vol. 45 • No 1 • May 2014. • www.scriptamedica.com 5 73 CASE REPORT 80 CASE REPORT Inferior Pancreaticoduodenal Artery Aneurysm Immune Hydrops Fetalis Associated with Obstruction of the Celiac Trunk Imuni Hidrops Fetalis and Cancer of the Head of the Pancreas D. JOJIĆ, J. PREDOJEVIĆ-SAMARDŽIĆ, G. GUZIJAN, S. PETROVIĆ-TEPIĆ Aneurizma donje pankreatikoduodenalne arterije udružena sa opstrukcijom celijačnog stabla i 84 BOOK REVIEW Clinical anatomy karcinomom glave pankreasa J. ĆULUM, D. GOLIĆ, A. GUZIJAN, D. JOVIĆ, B. JAKOVLJEVIĆ, A. 85 BOOK REVIEW JAKOVLJEVIĆ, D. GRAHOVA Treatment of War Wounds to the Extremities 76 CASE REPORT Giant Mucinous Ovarian Cystadenocarcinoma 86 Instructions for Autors Gigantski mucinozni cistoadenokarcinom jajnika F. KONJIĆ, Z. RIFATBEGOVIĆ, M. PIRIĆ, Š. HASUKIĆ Scripta Medica 6 Vol. 46 • No 1 • April 2015. • www.scriptamedica.com Editor’s Letter Dear Colleagues, This path, that we have chosen together, will place Scripta Medica in a database such as DAPJ and KOBSON, etc. We are delighted that we have gained your trust and that you have decided to participate in the development of Thank you for your trust, Scripta Medica with your papers. Editor in chief Our achievement is reflected in the increasing quality and Prof. Predrag Grubor number of published papers, as well as the introduction of new contents in every subsequent publication. With such cooperation and your constructive contribution, we are in a position to publish Scripta Medica several times a year. ORIGINAL ARTICLE UDK 616.314-084: 616.89-008.441-085 Ljiljana Marković Đurić1, Anita Kos-Dragičević2, Marina Bektašević3 Dental Anxiety in Children Aged 1 PHI „ Dom zdravlja”, Kneževo 6-15 years 2 Pfizer BH d.o.o. 3 PHI „Dom zdravlja“, Banjaluka Contact address: Ljiljana Marković Đurić Rajka Dukića 4 ABSTRACT 78230 Kneževo Tel: 00387 65 211 095 Introduction: Dental anxiety and fear are the source of serious health problems in e-mail: children. The prevalence of dental anxiety in children and adults widely ranges from [email protected] 5-40%. Aims of the study: The aim of this study was to determine the level of dental anxiety among school aged children and to point out these issues in school children, in order to get better understanding and management of treatment in these children, and take appropriate preventive measures. Patients and Methods: The study was conducted on 70 children (42 males and 28 females) in age of 6-15 years, in „Health“ Kneževo during period of March/April 2014. Children were divided into two groups according to their age. First group consisted of children aged 6-10, and the second one 11-15 years old. We studied the prevalence of dental anxiety, gender and age distribution, the degree of dental anxiety, and the impact of previous dental experience. The assessment of dental anxiety was obtained using Dental anxiety scale (DAS). Results: Average DAS in children was 9.94. There was no statistically significant difference in the occurrence of dental anxiety in relation to sex and age of a child. In 18.57% of the children, severe dental anxiety was identified. Previous negative dental experience significantly affects the level of anxiety in children. Conclusion: Dental anxiety is an actual and widespread problem. A negative dental experience has a great impact on the development of dental anxiety. Key words: dental anxiety in children, the prevalence, negative dental experience Submitted: December 12th, 2014 DOI: 10.7251/SMDEN1501007M (Scr Med 2015:46:7-11) Accepted: December 31th, 2014 Introduction Fear is the immediate response that falls within the sphere of emotional behavior, and the result is an emotional The major barriers for dental treatment in the pedriatic response to a real threat.
Recommended publications
  • The Membrane Complement Regulatory Protein CD59 and Its Association with Rheumatoid Arthritis and Systemic Lupus Erythematosus
    Current Medicine Research and Practice 9 (2019) 182e188 Contents lists available at ScienceDirect Current Medicine Research and Practice journal homepage: www.elsevier.com/locate/cmrp Review Article The membrane complement regulatory protein CD59 and its association with rheumatoid arthritis and systemic lupus erythematosus * Nibhriti Das a, Devyani Anand a, Bintili Biswas b, Deepa Kumari c, Monika Gandhi c, a Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India b Department of Zoology, Ramjas College, University of Delhi, India c University School of Biotechnology, Guru Gobind Singh Indraprastha University, India article info abstract Article history: The complement cascade consisting of about 50 soluble and cell surface proteins is activated in auto- Received 8 May 2019 immune inflammatory disorders. This contributes to the pathological manifestations in these diseases. In Accepted 30 July 2019 normal health, the soluble and membrane complement regulatory proteins protect the host against Available online 5 August 2019 complement-mediated self-tissue injury by controlling the extent of complement activation within the desired limits for the host's benefit. CD59 is a membrane complement regulatory protein that inhibits the Keywords: formation of the terminal complement complex or membrane attack complex (C5b6789n) which is CD59 generated on complement activation by any of the three pathways, namely, the classical, alternative, and RA SLE the mannose-binding lectin pathway. Animal experiments and human studies have suggested impor- Pathophysiology tance of membrane complement proteins including CD59 in the pathophysiology of rheumatoid arthritis Disease marker (RA) and systemic lupus erythematosus (SLE). Here is a brief review on CD59 and its distribution, structure, functions, and association with RA and SLE starting with a brief introduction on the com- plement system, its activation, the biological functions, and relations of membrane complement regu- latory proteins, especially CD59, with RA and SLE.
    [Show full text]
  • Immuno 2014 No. 1
    Journal of Blood Group Serology and Molecular Genetics VOLUME 30, N UMBER 1, 2014 Immunohematology Journal of Blood Group Serology and Molecular Genetics Volume 30, Number 1, 2014 CONTENTS R EPORT 1 Indirect antiglobulin test-crossmatch using low-ionic-strength saline–albumin enhancement medium and reduced incubation time: effectiveness in the detection of most clinically significant antibodies and impact on blood utilization C.L. Dinardo, S.L. Bonifácio, and A. Mendrone, Jr. R EV I EW 6 Raph blood group system M. Hayes R EPORT 11 I-int phenotype among three individuals of a Parsi community from Mumbai, India S.R. Joshi C A SE R EPORT 14 Evans syndrome in a pediatric liver transplant recipient with an autoantibody with apparent specificity for the KEL4 (Kpb) antigen S.A. Koepsell, K. Burright-Hittner, and J.D. Landmark R EV I EW 18 JMH blood group system: a review S.T. Johnson R EPORT 24 Demonstration of IgG subclass (IgG1 and IgG3) in patients with positive direct antiglobulin tests A. Singh, A. Solanki, and R. Chaudhary I N M EMOR ia M 28 George Garratty, 1935–2014 Patricia A. Arndt and Regina M. Leger 30 A NNOUNCEMENTS 34 A DVERT I SEMENTS 39 I NSTRUCT I ONS FOR A UTHORS E D I TOR - I N -C H I EF E D I TOR ia L B OA RD Sandra Nance, MS, MT(ASCP)SBB Philadelphia, Pennsylvania Patricia Arndt, MT(ASCP)SBB Paul M. Ness, MD Pomona, California Baltimore, Maryland M A N AG I NG E D I TOR James P.
    [Show full text]
  • Introduction to the Rh Blood Group.Pdf
    Introduction to the Rhesus Blood Group Justin R. Rhees, M.S., MLS(ASCP)CM, SBBCM University of Utah Department of Pathology Medical Laboratory Science Program Objectives 1. Describe the major Rhesus (Rh) blood group antigens in terms of biochemical structure and inheritance. 2. Describe the characteristics of Rh antibodies. 3. Translate the five major Rh antigens, genotypes, and haplotypes from Fisher-Race to Wiener nomenclature. 4. State the purpose of Fisher-Race, Wiener, Rosenfield, and ISBT nomenclatures. Background . How did this blood group get its name? . 1937 Mrs. Seno; Bellevue hospital . Unknown antibody, unrelated to ABO . Philip Levine tested her serum against 54 ABO-compatible blood samples: only 13 were compatible. Rhesus (Rh) blood group 1930s several cases of Hemolytic of the Fetus and Newborn (HDFN) published. Hemolytic transfusion reactions (HTR) were observed in ABO- compatible transfusions. In search of more blood groups, Landsteiner and Wiener immunized rabbits with the Rhesus macaque blood of the Rhesus monkeys. Rhesus (Rh) blood group 1940 Landsteiner and Wiener reported an antibody that reacted with about 85% of human red cell samples. It was supposed that anti-Rh was the specificity causing the “intragroup” incompatibilities observed. 1941 Levine found in over 90% of erythroblastosis fetalis cases, the mother was Rh-negative and the father was Rh-positive. Rhesus macaque Rhesus (Rh) blood group Human anti-Rh and animal anti- Rh are not the same. However, “Rh” was embedded into blood group antigen terminology. The
    [Show full text]
  • 3407 M16141436 19 3.Pdf
    Immunohematology JOURNAL OF BLOOD GROUP SEROLOGY AND EDUCATION V OLUME 19, NUMBER 3, 2003 Immunohematology JOURNAL OF BLOOD GROUP SEROLOGY AND EDUCATION V OLUME 19, NUMBER 3, 2003 CONTENTS 73 DNA analysis for donor screening of Dombrock blood group antigens J.R. STORRY, C.M.WESTHOFF,D.CHARLES-PIERRE,M.RIOS,K.HUE-ROYE,S.VEGE,S.NANCE, AND M.E. REID 77 Studies on the Dombrock blood group system in non-human primates C. MOGOS,A.SCHAWALDER,G.R. HALVERSON, AND M.E. REID 83 Murine monoclonal antibodies can be used to type RBCs with a positive DAT G.R. HALVERSON,P.HOWARD,H.MALYSKA,E.TOSSAS, AND M.E. REID 86 Rh antigen and phenotype frequencies and probable genotypes for the four main ethnic groups in Port Harcourt, Nigeria Z.A. JEREMIAH AND F.I. BUSERI 89 Antibodies detected in samples from 21,730 pregnant women S. JOVANOVIC-SRZENTIC,M.DJOKIC,N.TIJANIC,R.DJORDJEVIC,N.RIZVAN,D.PLECAS, AND D. FILIMONOVIC 93 BOOK REVIEWS S. GERALD SANDLER,MD THERESA NESTER,MD 95 COMMUNICATIONS Letter to the Editors Letter From the Editors Irregular RBC antibodies in the Ortho Dedication sera of Brazilian pregnant women 97 IN MEMORIAM BERTIL CEDEGREN,MD 98 99 ANNOUNCEMENTS ADVERTISEMENTS 103 INSTRUCTIONS FOR AUTHORS EDITOR-IN-CHIEF MANAGING EDITOR Delores Mallory, MT(ASCP)SBB Mary H. McGinniss,AB, (ASCP)SBB Rockville, Maryland Bethesda, Maryland TECHNICAL EDITOR SENIOR MEDICAL EDITOR Christine Lomas-Francis, MSc Scott Murphy, MD New York, New York Philadelphia, Pennsylvania ASSOCIATE MEDICAL EDITORS S. Gerald Sandler, MD Geralyn Meny, MD Ralph Vassallo, MD Washington, District of Columbia Philadelphia, Pennsylvania Philadelphia, Pennsylvania EDITORIAL BOARD Patricia Arndt, MT(ASCP)SBB W.
    [Show full text]
  • ABH Secretor and Lewis Subtype Status Peter J
    Metabolic and Immunologic Consequences of ABH Secretor and Lewis Subtype Status Peter J. D’Adamo, ND, and Gregory S. Kelly, ND Abstract Determining ABH secretor phenotype and/or Lewis (Le) blood group status can be useful to the metabolically-oriented clinician. For example, differences in ABH secretor status drastically alter the carbohydrates present in body fluids and secretions; this can have profound influence on microbial attachment and persistence. Lewis typing is one genetic marker which might help identify subpopulations of individuals genetically prone to insulin resistance, autoimmunity, and heart disease. Understanding the clinical significance of ABH secretor status and the Lewis blood groups can provide insight into seemingly unrelated aspects of physiology, including variations in intestinal alkaline phosphatase activity, propensities toward blood clotting, reliability of some tumor markers, the composition of breast milk, and several generalized aspects of the immune function. Since the relevance of ABH blood group antigens as tumor markers and parasitic/bacterial/viral receptors and their association with immunologically important proteins is now well established, the prime biologic role for ABH blood group antigens may well be independent and unrelated to the erythrocyte. (Altern Med Rev 2001;6(4):390-405) Functional and Genetic Factors Involved in ABH Secretion The term “ABH secretor,” as used in blood banking, refers to secretion of ABO blood group antigens in fluids such as saliva, sweat, tears, semen, and serum. A person who is an ABH secretor will secrete antigens according to their blood group; for example, a group O individual will secrete H antigen, a group A individual will secrete A and H antigens, etc.
    [Show full text]
  • Comprehensive Red Blood Cell and Platelet Antigen Prediction from Whole Genome Sequencing: Proof of Principle
    BLOOD GROUP GENOMICS Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle William J. Lane,1,2 Connie M. Westhoff,3 Jon Michael Uy,1 Maria Aguad,1 Robin Smeland-Wagman,1 Richard M. Kaufman,1 Heidi L. Rehm,1,2,4,5 Robert C. Green,2,5,6 and Leslie E. Silberstein7 for the MedSeq Project* rediction of red blood cell (RBC) and platelet BACKGROUND: There are 346 serologically defined (PLT) antigens using DNA assays has the poten- red blood cell (RBC) antigens and 33 serologically tial to augment or replace traditional serologic defined platelet (PLT) antigens, most of which have antigen typing in many situations. DNA-based known genetic changes in 45 RBC or six PLT genes that P typing methods are more easily automated, amenable to correlate with antigen expression. Polymorphic sites multiplexing, and do not require expensive and some- associated with antigen expression in the primary times difficult to obtain serologic immunoglobulin literature and reference databases are annotated according to nucleotide positions in cDNA. This makes antigen prediction from next-generation sequencing data ABBREVIATIONS: CDS 5 coding DNA sequence; NGS 5 challenging, since it uses genomic coordinates. next-generation sequencing; SNP(s) 5 single-nucleotide STUDY DESIGN AND METHODS: The conventional polymorphism(s); WGS 5 whole genome sequencing. cDNA reference sequences for all known RBC and PLT From the 1Department of Pathology, the 6Division of Genetics, genes that correlate with antigen expression were Department of Medicine, and the 7Division of Transfusion aligned to the human reference genome. The alignments Medicine, Department of Pathology, Brigham and Women’s allowed conversion of conventional cDNA nucleotide Hospital; and 2Harvard Medical School, Boston, Massachusetts; positions to the corresponding genomic coordinates.
    [Show full text]
  • New Methods for Characterization of N-Type Glycosylation of Proteins by Integration of LC-MS/MS and NMR
    New Methods for Characterization of N-type Glycosylation of Proteins by Integration of LC-MS/MS and NMR Thesis Submitted in fulfillment of the requirements of the degree Doctor rer. nat. at the Department of Chemistry, Faculty of Sciences, University of Hamburg by Alena Wiegandt from Hamburg Hamburg, 2016 This thesis was prepared at the Institute for Organic Chemistry from October 2012 to July 2016 (managing director: Prof. Dr. C.B.W. Stark). I would like to thank Prof. Dr. Bernd Meyer for his continuous and motivating support during the work on my PhD thesis. I would like to thank Prof. Dr. Dr. h. c. mult. Wittko Francke for being the second reviewer of this thesis. 1st Reviewer: Prof. Dr. Bernd Meyer 2nd Reviewer: Prof. Dr. Dr. h.c. mult. Wittko Francke Date of defense: 07.04.2017 OUTLINE Outline ABBREVIATIONS ..................................................................................................................... VIII 1 SUMMARY ............................................................................................................................ 1 2 ZUSAMMENFASSUNG .......................................................................................................... 4 3 INTRODUCTION ................................................................................................................... 7 3.1 Glycosylation of Proteins - Biosynthesis, Structures, Functions .................................... 8 3.2 Glycans in Human Diseases .........................................................................................
    [Show full text]
  • Red Blood Cell Antigen Genotyping
    Red Blood Cell Antigen Genotyping Testing is useful in determining allelic variants predicting red blood cell (RBC) antigen phenotypes for patients with recent history of transfusion or with conflicting serological antibody results due to partial, variant, or weak expression antigens. Also Tests to Consider useful as an aid in management of hemolytic disease of the fetus and newborn (HDFN). Typical Testing Strategy Disease Overview Phenotype Testing Evaluates specific RBC antigen presence by serology Prevalence and/or Incidence Results can aid in selecting antigen negative RBC units Erythrocyte alloimmunization occurs in up to 58% of sickle cell patients, up to 35% in other transfusion-dependent patients, and in approximately 0.8% of all pregnant Antigen Testing, RBC Phenotype women. Extended 0013020 Method: Hemagglutination Serological testing includes K, Fya, Fyb, Jka, Symptoms Jkb, S, s (k, cellano, testing performed if indicated) to assess maternal or paternal RBC Transfusion reactions or HDFN can occur due to alloimmunization: phenotype status. Antigen Testing, Rh Phenotype 0013019 Intravascular hemolysis: hemoglobinuria, jaundice, shock Extravascular hemolysis: fever and chills Method: Hemagglutination HDFN: fetal hemolytic anemia, hepatosplenomegaly, jaundice, erythroblastosis, Antigen testing for D, C, E, c, and e to assess neurological damage, hydrops fetalis maternal, paternal, or newborn Rh phenotype status Clinical presentation is variable and dependent upon the specific antibody and recipient factors Genotype Testing May help
    [Show full text]
  • Copyrighted Material
    P1: SFK/UKS P2: SFK/UKS QC: SFK/UKS T1: SFK Color: 1C ind BLBK321-Paidas September 7, 2010 15:9 Trim: 244mm X 172mm Index Note: Italicized f and t refer to figures and tables, respectably. Abciximab, 207 anti-A, 29 ABO blood group, 28–9 anti-B, 29 ABO hemolytic disease, 29 anti-c, 28 acetaminophen, 45 anticoagulant therapy, 111–43 acidosis, 197 antiplatelet agents, 141 acquired thrombophilia, 68–74. See also low molecular weight heparin, 127–30, inherited thrombophilia 140–41 diagnosis of, 68, 72t for mechanical heart valve incidence of, 68 thromboprophylaxis, 138–43 obstetrical complications, 73 unfractionated heparin, 127, 140–41 pathogenecity, 71 for venous thromboembolism, 111–18 pathophysiology of, 71 for venous thromboembolism in pregnancy, activated partial thromboplastin time (aPTT), 118–36 127, 173 vitamin K antagonists, 139–40 activated protein C (APC), 6, 74–9, 191 anti-D immunoglobulin, 33 activated recombinant factor VII (rFVIIa), 165 antenatal, 33 activation markers, 7 dose regime, 35 acute fatty liver of pregnancy (AFLP), 187 indications for RhD-negative mothers, 35 acute leukemia, 20 antifibrinolytic drugs, 202 ADAMST13 deficiency, 44 anti-Kell, 28 adenosine diphosphate (ADP), 60, 61–2 f antiphospholipid antibody syndrome (APAS), adherent placenta, 169–70 68–74 alpha-delta storage pool deficiency, 165 clinical consequences, 72–3 Alport syndrome, 60 diagnosis of, 68, 72t amegakaryocytic thrombocytopenia, 60 incidence of, 68 amniotic fluid embolism (AFE), 184–5 obstetrical complications, 73 anaphylaxis, 211 pathogenicity, 71 anemia,
    [Show full text]
  • Blood Group Antigens: Principles and Practice
    Blood Group Antigens: principles and practice Peyman Eshghi Prof. of Pediatric Hematology & Oncology 3-95 References 1. NATHAN AND OSKI’S HEMATOLOGY AND ONCOLOGY OF INFANCY AND CHILDHOOD, 8 th ed.,2015 2. Christopher D. Hillyer,et al.,Handbook of PEDIATRIC TRANSFUSION MEDICINE,2004 3. Rossi’sPrinciplesofTransfusionMedicine,5th ed.,2015 • More than 250 Ags • Erythrocyte antigens are polymorphic inherited structural characteristics located on proteins, glycoproteins, or glycolipids on the outside surface of the RBC membrane. • Erythrocyte antigens are clinically important in the immune destruction of RBCs in allogeneic blood transfusions, maternal-fetal blood group incompatibility, autoimmune hemolytic anemia, and organ transplantation Carbohydrate blood groups •ABO •LEWIS •P •Hh • The fucosyltransferase (and thus the H antigen) is present in all persons except those with the rare Bombay (Oh) phenotype • The genes for the A and B blood group antigens are codominant • Antigens A&B are not fully developed until 2 to 4 years of age:ABO hemolytic disease of the newborn (HDN) is usually a mild disease • Isohemagglutinins from group A and B individuals are predominantly immunoglobulin M (IgM) that do not usually cross the placenta and cause HDN. • However, as group O serum contains IgG isohemagglutins, ABO HDN is most frequently seen in non–group O infants of group O mothers. Molecular basis of ABH • Three genes control the expression of the ABO antigens: • ABO, Hh, and Se. • The H gene attaches L-fucose to the RBC membrane-anchored polypeptide • On red cells, platelets ,and endothelium ,ABH is primarily expressed on type 2 chain or lactosamine based structures. • The secretor gene (Se) controls the individual’s ability to secrete soluble • Genitourinary and gastrointestinal tissues, are rich in type1 chain ABH antigens : depends on secretor gen FUT2 • The classic Bombay phenotype: is an H-deficient nonsecretor(hh,se/se), with an absence of both type1 and type2 chain ABH antigens.
    [Show full text]
  • Blood Group Have Increased Susceptibility to Symptomatic \(Vibrio\) \(Cholerae\) O1 Infection
    Individuals with Le(a+b−) Blood Group have Increased Susceptibility to Symptomatic \(Vibrio\) \(cholerae\) O1 Infection The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Arifuzzaman, Mohammad, Tanvir Ahmed, Mohammad Arif Rahman, Fahima Chowdhury, Rasheduzzaman Rashu, Ashraful I. Khan, Regina C. LaRocque, et al. 2011. Individuals with Le(a+b−) blood group have increased susceptibility to symptomatic \(Vibrio\) \(cholerae\) O1 infection. PLoS Neglected Tropical Diseases 5(12): e1413. Published Version doi:10.1371/journal.pntd.0001413 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:9369412 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Individuals with Le(a+b2) Blood Group Have Increased Susceptibility to Symptomatic Vibrio cholerae O1 Infection Mohammad Arifuzzaman1,2, Tanvir Ahmed1, Mohammad Arif Rahman1, Fahima Chowdhury1, Rasheduzzaman Rashu1, Ashraful I. Khan1, Regina C. LaRocque2,3, Jason B. Harris2,4, Taufiqur Rahman Bhuiyan1, Edward T. Ryan2,3,5, Stephen B. Calderwood2,3,6., Firdausi Qadri1*. 1 Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh, 2 Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America,
    [Show full text]
  • Obstetrics and Gynecology, Howard C
    Red Cell Alloimmunization Chapter 34 KeNNeth J. MOISe Jr Nomenclature 770 Indications 774 Hemolytic Disease of the Fetus Historic Perspectives 770 Diagnostic Methods 776 and Newborn Due to Non-RhD Incidence 771 Clinical Management 778 Antibodies 781 Pathophysiology 771 First Affected Pregnancy 778 Rhc 781 Rhesus Alloimmunization and Fetal/ Previously Affected Fetus or Infant 778 RhC, RhE, and Rhe 782 Neonatal Hemolytic Disease of the Intrauterine Transfusion 778 Duffy 782 Newborn 772 Technique 778 Kidd 782 Genetics 772 Complications and Outcome 780 Kell 782 Prevention of RhD Hemolytic Disease Neonatal Transfusions 780 in the Fetus and Newborn 773 Neurologic Outcome 780 History 773 Other Treatment Modalities 780 Preparations 773 Future Therapeutic Options 781 KEY ABBREVIATIONS these antibodies across the placenta during pregnancy results in fetal anemia, hyperbilirubinemia, and ultimately hydrops American Association of Blood Banks AABB fetalis. Before the advent of obstetric ultrasound, the perinatal American College of Obstetricians and ACOG effects of maternal red cell alloimmunization could be recog- Gynecologists nized only after birth in the affected neonate. Thus the neonatal Cytomegalovirus CMV consequences of maternal red cell alloimmunization came to be Circulating cell-free fetal DNA ccffDNA known as hemolytic disease of the newborn (HDN). Because the Deoxyribonucleic acid DNA peripheral blood smear of these infants demonstrated a large Diphosphatidylglycerol DPG percentage of circulating immature red cells known as erythro­ Fetal blood sampling FBS blasts, the newborn entity was also known as erythroblastosis Fetomaternal hemorrhage FMH fetalis. Today, ultrasound and fetal blood sampling (FBS) make Grams per deciliter g/dL the detection of the severely anemic fetus a reality.
    [Show full text]