Author Manuscript Published OnlineFirst on August 18, 2011; DOI: 10.1158/0008-5472.CAN-11-0573 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Faget et al “innate immune recognition trigger CCL22 by breast tumor cells” Early detection of tumor cells by innate immune cells leads to Treg recruitment through CCL22 production by tumor cells Running title : innate immune recognition trigger CCL22 by breast tumor cells Julien Faget1,2,3, Cathy Biota1,2,3, Thomas Bachelot1,2,3, Michael Gobert1,2,3, Isabelle Treilleux1,2,3, Nadège Goutagny1,2,3, Isabelle Durand1,3, Sophie Léon-Goddard1,2,3, Jean Yves Blay1,2,3, Christophe Caux1,2,3 and Christine Ménétrier-Caux1,2,3 Affiliations : 1- Centre Léon Bérard, Lyon, France, 2- Université Lyon 1, F-69000 Lyon, France, 3- Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France Corresponding author: Dr Christine MENETRIER-CAUX, Centre Léon Bérard, CRCL INSERM U1052/CNRS 5286, 28 rue Laennec, 69373 Lyon cedex 08, France; Tel : (33) 4 78 78 27 50; Fax : (33) 4 78 78 27 20; e-mail :
[email protected] Key-words : CCL22, Treg, tumor cells, breast carcinoma, recruitment Scientific category: Immunology Conflict of interest disclosure: The authors declare no competing financial interest. Aknowledgments : JF and MG are grant holders of the Ligue Nationale contre le Cancer. This work was financially supported in part by grants from “le comité départemental du Rhône de Ligue Contre le Cancer “,the ARC association (ARC-5074), the Breast Cancer Research Fundation and Institut National du Cancer grant INCA ACI-63-04, ACI 2007-2009.