Ehrlichiosis

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Ehrlichiosis Ehrlichiosis What is ehrlichiosis and can also have a wide range of signs Who should I contact, if I what causes it? including loss of appetite, weight suspect ehrlichiosis? Ehrlichiosis (air-lick-ee-OH-sis) is a loss, prolonged fever, weakness, and In Animals – group of similar diseases caused by bleeding disorders. Contact your veterinarian. In Humans – several different bacteria that attack Can I get ehrlichiosis? the body’s white blood cells (cells Contact your physician. Yes. People can become infected involved in the immune system that with ehrlichiosis if they are bitten by How can I protect my animal help protect against disease). The an infected tick (vector). The disease organisms that cause ehrlichiosis are from ehrlichiosis? is not spread by direct contact with found throughout the world and are Ehrlichiosis is best prevented by infected animals. However, animals spread by infected ticks. Symptoms in controlling ticks. Inspect your pet can be carriers of ticks with the animals and humans can range from frequently for the presence of ticks bacteria and bring them into contact mild, flu-like illness (fever, body aches) and remove them promptly if found. with humans. Ehrlichiosis can also to severe, possibly fatal disease. Contact your veterinarian for effective be transmitted through blood tick control products to use on What animals get transfusions, but this is rare. your animal. ehrlichiosis? Disease in humans varies from How can I protect myself Many animals can be affected by mild infection to severe, possibly fatal ehrlichiosis, although the specific infection. Symptoms may include from ehrlichiosis? bacteria involved may vary with the flu-like signs (chills, body aches and The risk for infection is decreased animal species. Ehrlichiosis has been headache). In a small number of by preventing tick bites. When reported in dogs, coyotes, wolves, cases a skin rash may be seen. Severe entering tick-prone areas, wear insect foxes, cats, cattle, sheep, goats, horses, cases may have a cough, difficulty repellent, a long sleeved shirt, long llamas, deer, elk, and rodents. breathing, prolonged fever, kidney pants and closed-toed shoes. Check problems, bleeding disorders, and frequently for ticks and remove them How can my animal get possibly seizures or coma. promptly if found. Removing a tick ehrlichiosis? before it has been attached for more Animals become infected with than 24 hours greatly reduces the risk the bacteria that cause ehrlichiosis of infection. after being bitten by an infected tick For More Information (vector). Less commonly, infection Ehrlichiosis can also be transmitted through a is caused by bacteria, CFSPH Technical Fact Sheets. Ehrlichiosis blood transfusion in animals. spread by ticks, that attack at http://www.cfsph.iastate.edu/ DiseaseInfo/ cells of the immune system How does ehrlichiosis affect of many species. CDC website. Human Ehrlichiosis at http:// my animal? www.cdc.gov/ehrlichiosis/ Disease from ehrlichiosis infection can vary depending on the bacteria involved. Signs are non-specific, such as reduced appetite, fever, swollen lymph nodes, depression, weight loss, vomiting and diarrhea. Infected animals may recover on Left photo American dog tick (From www. their own or the infection can persist discoverlife.org). Right photo shows bacteria in a white blood cell (From webmedic4u) to a long term (chronic) illness. This © 2013.
Recommended publications
  • Ehrlichiosis in Dogs Animal Veterinary Associations Borne Diseases
    21 Working ECAVA F F A E V C A A C V Group on E A F F A E V C Canine A FECAVA Federation of European Companion vector Ehrlichiosis in dogs Animal Veterinary Associations borne diseases WERSJA POPRAWIONA A Ehrlichia spp. !! Ehrlichiosis is a tick-borne disease caused by Ehrlichia spp, an obligate intracellular gram-negative bacterium of the Anaplasmataceae family. In Europe, Ehrlichia canis causes canine monocytic ehrlichiosis ! (CME) The tick Rhipicephalus sanguineus is its main vector in Europe. Dogs and wild canids act as reservoirs. The disease has a subclinical, acute asymptomatic phase and chronic phase. The prognosis for chronically sick dogs is poor, ! !! The incubation period is 1-4 weeks. German Shepherds and Siberian Huskies appear to be more susceptible to clinical ehrlichiosis with more severe clinical !! presentations than other breeds. When to suspect infection? Origin / travelling history Clinical signs o Dogs that live in, originate from or have travelled to countries where the parasite is endemic are at risk. Weight loss, anorexia, lethargy, fever o Dogs in countries not currently considered endemic Bleeding disorders: petechiae/ecchymoses of the skin, mucous o o should not be considered free of risk. membranes and conjunctivas, hyphaema, epistaxis Lymphadenomegaly o How can it be confirmed? o Splenomegaly o Ocular signs: conjunctivitis, uveitis, corneal oedema Blood smear: Visualisation of intracellular bacteria on blood o Neurological signs (less common): seizures, ataxia, paresis, smears stained with Giemsa or similar. Sensitivity is poor: hyperaesthesia, cranial nerve deficits E. canis morulae in monocytes are visualised in only 4% (meningitis/meninigoencephalitis) cases of acute infections.
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  • Ehrlichiosis and Anaplasmosis Are Tick-Borne Diseases Caused by Obligate Anaplasmosis: Intracellular Bacteria in the Genera Ehrlichia and Anaplasma
    Ehrlichiosis and Importance Ehrlichiosis and anaplasmosis are tick-borne diseases caused by obligate Anaplasmosis: intracellular bacteria in the genera Ehrlichia and Anaplasma. These organisms are widespread in nature; the reservoir hosts include numerous wild animals, as well as Zoonotic Species some domesticated species. For many years, Ehrlichia and Anaplasma species have been known to cause illness in pets and livestock. The consequences of exposure vary Canine Monocytic Ehrlichiosis, from asymptomatic infections to severe, potentially fatal illness. Some organisms Canine Hemorrhagic Fever, have also been recognized as human pathogens since the 1980s and 1990s. Tropical Canine Pancytopenia, Etiology Tracker Dog Disease, Ehrlichiosis and anaplasmosis are caused by members of the genera Ehrlichia Canine Tick Typhus, and Anaplasma, respectively. Both genera contain small, pleomorphic, Gram negative, Nairobi Bleeding Disorder, obligate intracellular organisms, and belong to the family Anaplasmataceae, order Canine Granulocytic Ehrlichiosis, Rickettsiales. They are classified as α-proteobacteria. A number of Ehrlichia and Canine Granulocytic Anaplasmosis, Anaplasma species affect animals. A limited number of these organisms have also Equine Granulocytic Ehrlichiosis, been identified in people. Equine Granulocytic Anaplasmosis, Recent changes in taxonomy can make the nomenclature of the Anaplasmataceae Tick-borne Fever, and their diseases somewhat confusing. At one time, ehrlichiosis was a group of Pasture Fever, diseases caused by organisms that mostly replicated in membrane-bound cytoplasmic Human Monocytic Ehrlichiosis, vacuoles of leukocytes, and belonged to the genus Ehrlichia, tribe Ehrlichieae and Human Granulocytic Anaplasmosis, family Rickettsiaceae. The names of the diseases were often based on the host Human Granulocytic Ehrlichiosis, species, together with type of leukocyte most often infected.
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  • Canine Ehrliciosis in Australia
    Canine ehrlichiosis in Australia Fact sheet Introductory statement Australia was previously believed to be free of Ehrlichia canis. During 2020, the organism was detected in Australian dogs for the first time. Infection with E. canis (ehrlichiosis) is a notifiable disease in Australia. If you suspect ehrlichiosis in Australia, call the Emergency Animal Disease hotline on 1800 675 888. The disease is also known as canine monocytic ehrlichiosis and can cause serious illness and death in dogs. Aetiology The organism Ehrlichia canis, is an obligate gram negative intracellular rickettsial bacterium belonging to the family Anaplasmataceae. It is transmitted through tick bites, in particular the bite of the brown dog tick (Rhipicephalus sanguineus). Natural hosts Dogs (Canis lupus familiaris) are considered the natural hosts of the organism. Other canids such as foxes and wolves are known to become infected with the bacterium (Santoro et al. 2016). It is assumed that dingos, a uniquely Australian ancient dog breed which some people consider a different species to domestic and wild dogs, may also become infected, and may be susceptible to disease from E. canis. On rare occasions, humans or cats can become infected from a tick bite (Stich et al. 2008; Day 2011). World distribution E. canis occurs worldwide, particularly in tropical and subtropical regions. It was, until recently, considered to be absent from Australia. Occurrences in Australia In 2020, E. canis was detected in Western Australia and the Northern Territory. It was first detected in a small number of domesticated dogs in the Kimberly region of WA in May 2020. This was the first detection of ehrlichiosis in dogs in Australia outside of dogs that had been imported from overseas.
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  • Human Babesiosis and Ehrlichiosis Current Status
    IgeneX_v1_A4_A4_2011 27/04/2012 17:26 Page 49 Tick-borne Infectious Disease Human Babesiosis and Ehrlichiosis – Current Status Jyotsna S Shah,1 Richard Horowitz2 and Nick S Harris3 1. Vice President, IGeneX Inc., California; 2. Medical Director, Hudson Valley Healing Arts Center, New York; 3. CEO and President, IGeneX Inc., California, US Abstract Lyme disease (LD), caused by the Borrelia burgdorferi complex, is the most frequently reported arthropod-borne infection in North America and Europe. The ticks that transmit LD also carry other pathogens. The two most common co-infections in patients with LD are babesiosis and ehrlichiosis. Human babesiosis is caused by protozoan parasites of the genus Babesia including Babesia microti, Babesia duncani, Babesia divergens, Babesia divergens-like (also known as Babesia MOI), Babesia EU1 and Babesia KO1. Ehrlichiosis includes human sennetsu ehrlichiosis (HSE), human granulocytic anaplasmosis (HGA), human monocytic ehrlichiosis (HME), human ewingii ehrlichiosis (HEE) and the recently discovered human ehrlichiosis Wisconsin–Minnesota (HWME). The resulting illnesses vary from asymptomatic to severe, leading to significant morbidity and mortality, particularly in immunocompromised patients. Clinical signs and symptoms are often non-specific and require the medical provider to have a high degree of suspicion of these infections in order to be recognised. In this article, the causative agents, geographical distribution, clinical findings, diagnosis and treatment protocols are discussed for both babesiosis and ehrlichiosis. Keywords Babesia, Ehrlichia, babesiosis, ehrlichiosis, human, Borrelia Disclosure: Jyotsna Shah and Nick Harris are employees of IGeneX. Richard Horowitz is an employee of Hudson Valley Healing Arts Center. Acknowledgements: The authors would like to thank Eddie Caoili, and Sohini Stone, for providing technical assistance.
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  • Report Communicable Diseases to the Local Health Department
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  • Canine Ehrlichiosis: Update
    Canine Ehrlichiosis: Update Barbara Qurollo, MS, DVM ([email protected]) Vector-Borne Disease Diagnostic Laboratory Dep. Clinical Sciences-College of Veterinary Medicine North Carolina State University Overview Ehrlichia species are tick-transmitted, obligate intracellular bacteria that can cause granulocytic or monocytic ehrlichiosis. Ehlrichia species that have been detected in the blood and tissues of clinically ill dogs in North America include Ehrlichia canis, E. chaffeenis, E. ewingii, E. muris and Panola Mountain Ehrlichia species (Table 1). Clinicopathologic abnormalities reported in dogs with ehrlichiosis vary depending on the species of Ehrlichia, strain variances and the immune or health status of the dog. The course of disease may present as subclinical, acute, chronic or even result in death (Table 1). E. canis and E. ewingii are the most prevalent and frequently described Ehrlichia infections in dogs. E. canis: Transmitted by Rhipicephalus sanguineus, E. canis is found world-wide. Within North America, the highest seroprevalence rates have been reported in the Southern U. S.2, 12 E. canis typically infects canine mononuclear cells. Canine monocytic ehrlichiosis (CME) is characterized by 3 stages: acute, subclinical and chronic. Following an incubation period of 1-3 weeks, infected dogs may remain subclinical or present with nonspecific signs including fever, lethargy, lymphadenopathy, splenomegaly, lameness, edema, bleeding disorders and mucopurulent ocular discharge. Less commonly reported nonspecific signs include vomiting, diarrhea, coughing and dyspnea. Bleeding disorders can include epistaxis, petechiae, ecchymoses, gingival bleeding and melena. Ocular abnormalities identified in E. canis infected dogs have included anterior uveitis, corneal opacity, retinal hemorrhage, hyphema, chorioretinal lesions and tortuous retinal vessels.8 Following an acute phase (2-4 weeks), clinical signs may resolve without treatment and the dog could remain subclinically infected indefinitely or naturally clear the pathogen.
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  • Ehrlichiosis Epidemiology
    Ehrlichiosis Epidemiology A. Agent: Ehrlichiosis was not recognized in the U.S. until the late 1980’s and became a reportable disease in 19991,2. Ehrlichiosis is a general name used to describe several bacterial diseases in humans and animals. In the United States, ehrlichiosis can be caused by three different species of gram negative bacteria: Ehrlichia chaffeensis, Ehrlichia ewingii, and Ehrlichia muris-like (EML)1,2. B. Clinical Description: Ehrlichiosis usually presents with non-specific symptoms, including fever, headache, fatigue, and muscle aches1,2. Chills, malaise, nausea, vomiting, diarrhea, confusion, and conjunctival infections can also occur1,2. Development of a skin rash is not a common feature of ehrlichiosis. About 60% of children and less than 30% of adults develop a rash1,2. The rash associated with Ehrlichia chaffeensis infection may range from maculopapular to petechial in nature, and is usually not itchy1,2. The combination of symptoms varies from person to person1,2. Severe illness can occur, including difficulty breathing or bleeding disorders1,2. Ehrlichiosis can be fatal if left untreated, and has a 1.8% case fatality rate. Immunocompromised individuals may experience a more severe clinical illness1,2. C. Vectors: The Ehrlichia bacteria are spread to humans by the bite of an infected tick. In the United States, Amblyomma americanum (lone star tick) is the primary vector of Ehrlichia chaffeensis and Ehrlichia ewingii1,2. The long star tick is often found in the southeastern and south central United States. Three states (Oklahoma, Missouri, and Arkansas) account for 30% of all reported E. chaffeensis infections1,2. A vector has not been established yet for Ehrlichia muris-like (EML), but human travel-associated cases have been identified in Minnesota and Wisconsin1,2.
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  • Zoonotic Diseases of Companion Animals – by Transmission
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  • The Prevalence of the Q-Fever Agent Coxiella Burnetii in Ticks Collected from an Animal Shelter in Southeast Georgia
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  • Health Alert Network Advisory: Tick-Borne Diseases in Nebraska
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  • Federal Register/Vol. 84, No. 24/Tuesday, February 5, 2019/Proposed Rules
    1678 Federal Register / Vol. 84, No. 24 / Tuesday, February 5, 2019 / Proposed Rules and complete to the best of the DEPARTMENT OF VETERANS which pertains to chronic fatigue individual’s knowledge, information, AFFAIRS syndrome (CFS), and 38 CFR 4.88b, and belief, and is made in good faith. which pertains to the schedule of 38 CFR Part 4 (iii) Submission of an opt-out notice ratings for infectious diseases and immune disorders (we note that the does not constitute agreement by the RIN 2900–AQ43 proposed changes for § 4.88b exclude rights owner or the individual the schedule of ratings for nutritional submitting the opt-out notice that the Schedule for Rating Disabilities: Infectious Diseases, Immune deficiencies—diagnostic codes (DC) proposed use is in fact noncommercial. Disorders, and Nutritional Deficiencies 6313, 6314, and 6315). VA last updated The submitter may choose to comment the schedule of ratings in § 4.88b on July upon whether the rights owner agrees AGENCY: Department of Veterans Affairs. 31, 1996 (see 61 FR 39875) and updated that the proposed use is noncommercial ACTION: Proposed rule. § 4.88a on July 19, 1995 (see 60 FR use, but failure to do so does not 37012). constitute agreement that the proposed SUMMARY: The Department of Veterans VA proposes to: (1) Update the use is in fact noncommercial. Affairs (VA) proposes to amend the medical terminology and definition of section of the VA Schedule for Rating (3) Multiple rights owners. Where a certain infectious diseases and immune Disabilities (VASRD or Rating Schedule) disorders; (2) add medical conditions pre-1972 sound recording has multiple that addresses infectious diseases and rights owners, only one rights owner not currently in the Rating Schedule; (3) immune disorders.
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