bioRxiv preprint doi: https://doi.org/10.1101/699819; this version posted July 16, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane 1# 1# 1 1 1 Maia Kinnebrew , Ellen J. Iverson , Bhaven B. Patel , Ganesh V. Pusapati , Jennifer H. Kong , Kristen A. 3 1,5 4 2 3* Johnson , Giovanni Luchetti , Douglas F. Covey , Christian Siebold , Arun Radhakrishnan and Rajat Rohatgi1* 1 Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, California, United States of America 2 Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK 3 Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 4 Department of Developmental Biology and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri, United States of America 5 Current address: Department of Physiological Chemistry, Genentech, South San Francisco, CA # MK and EJI contributed equally to this study. * Correspondence to
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[email protected] bioRxiv preprint doi: https://doi.org/10.1101/699819; this version posted July 16, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license.