Molecular Evidence of Stress-Induced Acute Heart Injury in a Mouse Model Simulating Posttraumatic Stress Disorder
Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder Ji-Hoon Choa,1, Inyoul Leea,1, Rasha Hammamiehb,1, Kai Wanga,1, David Baxtera, Kelsey Scherlera, Alton Etheridgea, Alena Kulchenkoa, Aarti Gautamb, Seid Muhieb, Nabarun Chakrabortyb, David J. Galasc, Marti Jettb, and Leroy Hooda,2 aInstitute for Systems Biology, Seattle, WA 98109; bIntegrative Systems Biology, US Army Center for Environmental Health Research, Fort Detrick, MD 21702; and cPacific Northwest Diabetes Research Institute, Seattle, WA 98122 Contributed by Leroy Hood, January 7, 2014 (sent for review December 2, 2013) Posttraumatic stress disorder (PTSD) is a common condition induced and subsequently, relate these disease-perturbed dynamical net- by life-threatening stress, such as that experienced by soldiers under works to the pathophysiology of the disease (10, 11). This ap- battlefield conditions. Other than the commonly recognized behav- proach may lead to more informative diagnostic markers for ioral and psychological dysfunction, epidemiological studies have identifying the disease early, provide information as to which also revealed that PTSD patients have a higher risk of other diseases, organs are disease-involved, and provide insights into therapeutic such as cardiovascular disorders. Using a PTSD mouse model, we approaches for reversing the progression of the disease. investigated the longitudinal transcriptomic changes in heart tissues Individuals with PTSD also have a higher risk of cardiovas- after the exposure to stress through intimidation. Our results revealed cular conditions, with an increased basal heart rate and blood acute heart injury associated with the traumatic experience, reflecting pressure, higher risk for hypertension and stroke, altered platelet the underlying biological injury processes of the immune response, activity, and elevated blood cholesterol and triglyceride levels extracellular matrix remodeling, epithelial-to-mesenchymal cell tran- (12–15).
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