Cardiovascular Disease
Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.
www.MedChemExpress.com 1 Cardiovascular Disease Inhibitors & Modulators
(+)-BAY-1251152 (-)-Blebbistatin Cat. No.: HY-103019 ((S)-(-)-Blebbistatin) Cat. No.: HY-13441
Bioactivity: (+)-BAY-1251152 is a CDK9 inhibitor extracted from patent WO Bioactivity: (-)-Blebbistatin is an S enantiomer of blebbistatin. 2014076091 A1, example 1. Blebbistatin is a potent and selective myosin II inhibitor
with IC50s ranging from 0.5 to 5 μM.
Purity: 99.73% Purity: 99.42% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine sulfate (20S)-Protopanaxatriol salt; Lupinidine sulfate pentahydrate) Cat. No.: HY-B1304 (20(S)-APPT; g-PPT) Cat. No.: HY-N0835
Bioactivity: (-)-Sparteine sulfate pentahydrate is a class 1a Bioactivity: (20S)-Protopanaxatriol is a metabolite of ginsenoside, works antiarrhythmic agent and a sodium channel blocker. It is an through the glucocorticoid receptor (GR) and oestrogen alkaloid, can chelate the bivalents calcium and magnesium. receptor (ER), and is also a LXRα inhibitor.
Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
(4-Acetamidocyclohexyl) nitrate (4E)-SUN9221 (BM121307) Cat. No.: HY-100295 Cat. No.: HY-U00367
Bioactivity: BM121307 is a guanylate cyclase activator that was in phase I Bioactivity: (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor development for the treatment of ischaemic heart disorders. and 5-HT2 receptor, with antihypertensive and anti-platelet The research has been discontinued. aggregation activities.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
(E)-Alprenoxime (R)-(-)-Phenylephrine hydrochloride (CDDD-1815) Cat. No.: HY-101804 (Phenylephrine hydrochloride) Cat. No.: HY-B0471
Bioactivity: (E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime Bioactivity: (R)-(-)-Phenylephrine hydrochloride is a selective
is a site-activated ocular β-blocker. α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for
α 1D, α 1B and α 1A receptors respectively.
Purity: >98% Purity: 98.10% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
(Z)2S,4R-Sacubitril (±)-Befunolol Cat. No.: HY-Z0075 Cat. No.: HY-101752
Bioactivity: (Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril Bioactivity: (±)-Befunolol is a β-adrenoceptor blocking agent. is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 1 mg, 5 mg
2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
(±)-Equol (±)-WS75624B Cat. No.: HY-100583A Cat. No.: HY-100312
Bioactivity: (±)-Equol is the racemate of equol. Equol is a metabolite of Bioactivity: (±)-WS75624B is an endothelin converting enzyme ( ECE) the soy isoflavones, daidzin and daidzein. inhibitor with an IC50 of 0.03 μg/mL.
Purity: 99.01% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 25 mg, 50 mg, 100 mg, 200 mg
1-Linoleoyl Glycerol 11beta-Hydroxyprogesterone (1-Linoleoyl-rac-glycerol; 1-Monolinolein) Cat. No.: HY-111346 (11β-Hydroxyprogesterone) Cat. No.: HY-N2337
Bioactivity: 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has Bioactivity: 11beta-Hydroxyprogesterone is a potent inhibitors of been isolated from S. chinensis roots. 11β-Hydroxysteroid dehydrogenase; also activates human
mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Purity: 99.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 10 mg, 50 mg
1400W Dihydrochloride 2R,4R-Sacubitril Cat. No.: HY-18731 Cat. No.: HY-78846
Bioactivity: 1400W dihydrochloride is a potent and selective inhibitor of Bioactivity: 2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is
human inducible NO synthase with Ki values of 7 nM. approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.
Purity: 99.66% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg
2R,4S-Sacubitril 2S,4R-Sacubitril Cat. No.: HY-78847 Cat. No.: HY-Z0081
Bioactivity: 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is Bioactivity: 2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with combination with valsartan for the treatment of patients with heart failure. heart failure.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 1 mg, 5 mg
2S,4S-Sacubitril 3-Amino-2-methylpropanoic acid Cat. No.: HY-78841 Cat. No.: HY-W012974
Bioactivity: 2S,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is Bioactivity: 3-Amino-2-methylpropanoic acid could induce browning of white approved by the Food and Drug Administration for use in fat and hepatic β-oxidation and is inversely correlated with combination with valsartan for the treatment of patients with cardiometabolic risk factors. heart failure.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 100 mg
www.MedChemExpress.com 3
3-Methylsalicylic acid 4,6-Dioxoheptanoic acid (o-Cresotic acid; Hydroxytoluic acid) Cat. No.: HY-B1399 Cat. No.: HY-W010184
Bioactivity: 3-Methylsalicylic acid is a salicylic acid derivative compound Bioactivity: 4,6-Dioxoheptanoic acid is a potent inhibitor of heme with marked fibrinolytic activity in human plasma by biosynthesis. activating its fibrinolytic system.
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 10 mg, 50 mg, 100 mg
4-Methylumbelliferone 5-Amino-4-oxopentanoic acid (Hymecromone; 4-MU) Cat. No.: HY-N0187 Cat. No.: HY-W000450
Bioactivity: 4-Methylumbelliferone is a hyaluronic acid biosynthesis Bioactivity: 5-Amino-4-oxopentanoic acid is a non-protein amino acid that inhibitor with antitumoral and antimetastatic effects. plays a rate-limiting role in heme biosynthesis.
Purity: 99.48% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg
5-HT2 antagonist 1 5-HT2A antagonist 1 Cat. No.: HY-U00365 Cat. No.: HY-U00286
Bioactivity: 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, Bioactivity: 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from with weak α1 adrenoceptor blocking activity. patent US5728835A and JP 1007727. 5-HT2A antagonist 1 may be useful in treatment of gastrointestinal disorders circulatory disorders.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
5-HT3-In-1 5-Lipoxygenase-In-1 Cat. No.: HY-U00413 Cat. No.: HY-U00308
Bioactivity: 5-HT3-In-1 is extracted from patent EP0748807A1, compound Bioactivity: 5-Lipoxygenase-In-1 is a 5-Lipoxygenase inhibitor extracted example 8. It shows 5-HT3 inhibition activity. from patent EP 331232 A2, table 4, compound example 4.10.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
5-R-Rivaroxaban A 779 (BAY 59-7939) Cat. No.: HY-76948 Cat. No.: HY-P0216
Bioactivity: 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban Bioactivity: A 779 is a specific antagonist of G-protein coupled receptor (BAY 59-7939) is a highly potent and selective, direct Factor (Mas receptor), which is an Ang1-7 receptor distinct from Xa ( FXa) inhibitor, achieving a strong gain in anti-FXa the classical AngII. Sequence: Asp-Arg-Val-Tyr-Ile-His-d-Ala.
potency ( IC50 0.7 nM; Ki 0.4 nM).
Purity: 99.72% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg
4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
A81988 Acebutolol hydrochloride (Abbott81988) Cat. No.: HY-U00188 Cat. No.: HY-17497A
Bioactivity: A81988 is a potent, competitive, non-peptidic antagonist of Bioactivity: Acebutolol Hydrochloride is a β-adrenergic receptors
angiotensin AT1 receptors. antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 5 g, 10 g
Acenocoumarol Acipimox Cat. No.: HY-B1014 (K-9321) Cat. No.: HY-B0283
Bioactivity: Acenocoumarol is an anticoagulant that functions as a Vitamin Bioactivity: Acipimox is a niacin derivative used as a hypolipidemic agent. K antagonist. Target: Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of… Purity: >98% Purity: 99.0% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg
ACT-132577 ACY-775 (aprocitentan) Cat. No.: HY-15895 Cat. No.: HY-19328
Bioactivity: ACT-132577 is the major and pharmacologically active Bioactivity: ACY-775 is a potent and selective inhibitor of the of histone
metabolite of macitentan, which is dual ETA/ETB antagonist deacetylase 6 ( HDAC6) with an IC50 of 7.5nM. designed for tissue targeting.
Purity: 96.0% Purity: 99.54% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Adrenomedullin (1-50), rat Adrenomedullin (AM) (13-52), human Cat. No.: HY-P1534 (ADM (1-52)) Cat. No.: HY-P1457
Bioactivity: Adrenomedullin (1-50), rat is a 50 amino acid peptide, which Bioactivity: Adrenomedullin (AM) (13-52), human is a 40 amino acid peptide, induces a selective arterial vasodilation via activation of which acts as an endothelium-dependent vasodilator agent. CGRP1 receptor.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg
Adrenomedullin (AM) (22-52), human AE-3763 (22-52-Adrenomedullin (human)) Cat. No.: HY-P1471 Cat. No.: HY-19406
Bioactivity: Adrenomedullin (AM) (22-52), human is an adrenomedullin Bioactivity: AE-3763 is a peptide-based human neutrophil elastase
receptor antagonist, and also antagonizes the calcitonin inhibitor with an IC50 of 29 nM. generelated peptide ( CGRP) receptor in the hindlimb vascular bed of the cat.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 250 mg, 500 mg
www.MedChemExpress.com 5
AE0047 Hydrochloride Aglafoline Cat. No.: HY-U00284 (Aglafolin; Rocaglamide U; (-)-Methyl rocaglate) Cat. No.: HY-19354
Bioactivity: AE0047 Hydrochloride is a calcium blocker, used in the Bioactivity: Aglafoline inhibits in a selective and concentration-dependent research of hypertensive disease. manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM. Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
AGN 192836 AHU-377 Cat. No.: HY-100300 (Sacubitril) Cat. No.: HY-15407
Bioactivity: AGN 192836 is a potent and selective α2 adrenergic agonist Bioactivity: AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. with EC s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C 50 AHU-377 is a component of the heart failure medicine LCZ696. receptor, respectively.
Purity: >98% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
AHU-377 hemicalcium salt Ajmaline (Sacubitril hemicalcium salt) Cat. No.: HY-15407A (Cardiorythmine; (+)-Ajmaline) Cat. No.: HY-B1167
Bioactivity: AHU-377 hemicalcium salt is a potent NEP inhibitor with an Bioactivity: Ajmaline is an alkaloid that is class Ia antiarrhythmic agent.
IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.
Purity: 99.61% Purity: 99.31% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 1 g 50 mg, 100 mg
Aligeron Aliskiren Cat. No.: HY-101602 (CGP 60536; CGP60536B; SPP 100) Cat. No.: HY-12176
Bioactivity: Aligeron is a non-selective prostaglandin (PG) antagonist, and Bioactivity: Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of has vasodilatory properties. 1.5 nM. IC50 value: 1.5 nM [1] Target: renin in vitro: Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core… Purity: >98% Purity: 99.57% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
Aliskiren hemifumarate Alisol C 23-acetate (CGP 60536; CGP60536B; SPP 100) Cat. No.: HY-12177 (23-O-Acetylalisol C; Alisol C monoacetate) Cat. No.: HY-N0856
Bioactivity: Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor Bioactivity: Alisol C 23-acetate, a natural product extracted from Alisma with IC50 of 1.5 nM. IC50 value: 1.5 nM [1] Target: renin in orientale, can significantly and strongly inhibit DTH response vitro: Aliskiren hemifumarate appears to bind to both the after oral administration. hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the… Purity: 99.47% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 10 mg, 50 mg, 100 mg
6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Almitrine mesylate (Almitrine bismesylate; Almitrine Almokalant bismethanesulfonate; Almitrine dimesylate) Cat. No.: HY-107319 (H 234/09) Cat. No.: HY-106855
Bioactivity: Almitrine mesylate, a peripheral chemoreceptor agonist, Bioactivity: Almokalant is a class III antiarrhythmic drug, acts as a inhibits selectively the Ca 2+-dependent K+ channel. potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K + current.
Purity: 99.36% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg
Ambrisentan Amezinium methylsulfate (BSF 208075; LU 208075) Cat. No.: HY-13209 (Amezinium metilsulfate; Lu-1631) Cat. No.: HY-A0275
Bioactivity: Ambrisentan is a selective ET type A receptor ( ETAR) Bioactivity: Amezinium metilsulfate has multiple mechanisms, including antagonist. stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.
Purity: 99.86% Purity: 98.79% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg, 1 g
Aminaftone Amiodarone (Aminaftone; Aminaphthone) Cat. No.: HY-19890 Cat. No.: HY-14187
Bioactivity: Aminaftone, a derivative of 4-aminobenzoic acid, downregulates Bioactivity: Amiodarone is an antiarrhythmic drug for inhibition of endothelin-1 ( ET-1) production in vitro by interfering with ATP-sensitive potassium channel with IC50 of 19.1 μM. Target: the transcription of the pre-pro-ET-1 gene. Potassium Channel Amiodarone shows beta blocker-like and potassium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg, 100 mg
Amiodarone hydrochloride Amlodipine Cat. No.: HY-14188 Cat. No.: HY-B0317
Bioactivity: Amiodarone is an antiarrhythmic drug for inhibition of Bioactivity: Amlodipine is a long-acting calcium channel blocker. ATP-sensitive potassium channel with IC50 of 19.1 μM. IC50 Value: 1.5 uM ( inhibit TBARS, LOOH and FPL formation)[1] in vitro: It was found that 10 uM amiodarone induces accumulation of ethidium bromide (5 ug/ml) in Saccharomyces cerevisiae… Purity: 99.82% Purity: 99.57% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g
Amlodipine besylate Amlodipine maleate (Amlodipine benzenesulfonate) Cat. No.: HY-B0317B Cat. No.: HY-B0317A
Bioactivity: Amlodipine besylate is a long-acting calcium channel blocker. Bioactivity: Amlodipine maleate is a long-acting calcium channel blocker.
Purity: 98.21% Purity: 99.87% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g
www.MedChemExpress.com 7
Anacetrapib Ancarolol (MK-0859) Cat. No.: HY-12090 Cat. No.: HY-100141
Bioactivity: Anacetrapib is a potent CETP inhibitor, with IC50s of 7.9±2.5 Bioactivity: Ancarolol is a beta-adrenergic blocking agent. nM and 11.8±1.9 nM for rhCETP and C13S CETP mutant, respectively.
Purity: 98.39% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg
Angiogenin 108-122 Angiotensin 1-7 Cat. No.: HY-P1516 (Angiotensin-(1-7); Ang-(1-7)) Cat. No.: HY-12403
Bioactivity: Angiogenin (108-122) is an angiogenin peptide. Bioactivity: Angiotensin (1-7) inhibits purified canine angiotensin
converting enzyme ( ACE) activity with an IC50 of 0.65 μM.
Purity: >98% Purity: 99.61% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg
Angiotensin II Angiotensin II (3-8), human Cat. No.: HY-113012 Cat. No.: HY-P1515
Bioactivity: Angiotensin II is a Vasoconstrictor that plays an endocrine Bioactivity: Angiotensin II (3-8), human is a less effective agonist at the
role in the regulation of blood pressure, fluid and angiotensin AT1 receptor. electrolyte homeostasis.
Purity: >98% Purity: >98% Clinical Data: Clinical Data: No Development Reported Size: Size: 5 mg, 10 mg, 25 mg
Angiotensin II (3-8), human TFA Angiotensin II human Cat. No.: HY-P1515A (Angiotensin II; Hypertensin II; Ang II; DRVYIHPF) Cat. No.: HY-13948
Bioactivity: Angiotensin II (3-8), human (TFA) is a less effective agonist Bioactivity: Angiotensin II human is a vasoconstrictor that acts on the
at the angiotensin AT1 receptor. AT1 and the AT2 receptor.
Purity: 98.99% Purity: 99.83% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in Water, 10 mg, 50 mg
Angiotensin III Angiotensin III, human, mouse Cat. No.: HY-113035 Cat. No.: HY-P1540
Bioactivity: Angiotensin III is an angiotensin 1 (AT1) and AT2 receptor Bioactivity: Angiotensin III, human, mouse is a heptapeptide, acts as an
agonist. endogenous angiotensin type 2 receptor (AT2R) agonist, with
IC50s of 0.648 nM and 21.1 nM for AT 2R and AT 1R, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 5 mg, 10 mg, 25 mg
8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Angiotensinogen (1-14), human Anipamil Cat. No.: HY-P1486 Cat. No.: HY-U00044
Bioactivity: Angiotensinogen (1-14), human is a fragment of the renin Bioactivity: Anipamil is a long-acting calcium channel blocker, used for substrate angiotensinogen, a precursor for all angiotensin the treatment of cardiovascular disease. peptides.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg
Anisindione Anti-hypertensive sulfonanilide 1 Cat. No.: HY-B0924 Cat. No.: HY-U00301
Bioactivity: Anisindione is a synthetic anticoagulant, prevents the Bioactivity: Anti-hypertensive sulfonanilide 1 is a potent antihypertensive formation of active procoagulation factors II, VII, IX, and X. agent extracted from patent EP0338793A2, compound XVIIIa,b*, example No.1.
Purity: 98.36% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 500 mg
Apararenone Apixaban (MT-3995) Cat. No.: HY-109002 (BMS-562247-01) Cat. No.: HY-50667
Bioactivity: Apararenone (MT-3995) is a novel non-steroidal Bioactivity: Apixaban is a highly selective, reversible inhibitor of
mineralocorticoid receptor antagonists under development Factor Xa with Ki of 0.08 nM and 0.17 nM in human and for the treatment of diabetic nephropathies and non-alcoholic rabbit, respectively. steatohepatitis.
Purity: 98.80% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Aprotinin Argatroban Cat. No.: HY-P0017 (Argipidine) Cat. No.: HY-B0375
Bioactivity: Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) Bioactivity: Argatroban is a direct, selective thrombin inhibitor.
inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
Purity: Purity: >98% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Argatroban monohydrate Arrhythmias-Targeting Compound 1 (Argipidine monohydrate) Cat. No.: HY-B0375A Cat. No.: HY-101750
Bioactivity: Argatroban monohydrate is a direct, selective thrombin Bioactivity: Arrhythmias-Targeting Compound 1 is used in the research of inhibitor. arrhythmias, extracted from patent WO 2001028992 A2.
Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 9
Arrhythmic-Targeting Compound 1 AS8351 Cat. No.: HY-U00393 (NSC51355) Cat. No.: HY-100744
Bioactivity: Arrhythmic-Targeting Compound 1 is used for the research of Bioactivity: AS8351 is a KDM5B inhibitor, which can induce and sustain arrhythmic disease, with nitrogen-containing spirocycles. active chromatin marks to facilitate the induction of cardiomyocyte-like cells.
Purity: >98% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
Asiaticoside Aspartic acid calcium (Madecassol) Cat. No.: HY-N0439 (Calcium L-aspartate) Cat. No.: HY-N0666B
Bioactivity: Asiaticoside, a trisaccaride triterpene from Centella asiatica, Bioactivity: Aspartic acid calcium (Calcium L-aspartate) is a chelate where suppresses TGF-β/Smad signaling through inducing Smad7 and calcium is attached to an amino acid naming L-Aspartic acid. inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; L-Aspartic acid is an amino acid and serves as a building Asiaticoside shows antioxidant, anti-inflammatory, and block for proteins in the body. anti-ulcer properties. Purity: 98.46% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg 1 g
Asymmetric dimethylarginine Atorvastatin hemicalcium salt Cat. No.: HY-113216 (Atorvastatin hemicalcium) Cat. No.: HY-17379
Bioactivity: Asymmetric dimethylarginine is an endogenous inhibitor of Bioactivity: Atorvastatin (hemicalcium salt) is a potent HMG-CoA nitric oxide synthase (NOS), and functions as a marker of reductase inhibitor with the IC50 value of 8 nM. endothelial dysfunction in a number of pathological states.
Purity: 98.0% Purity: 99.98% Clinical Data: Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg, 200 mg, 500 mg
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Cat. No.: HY-P1235 Cat. No.: HY-P1235A
Bioactivity: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a Bioactivity: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way. in a dose-dependent way. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 500u g, 1 mg, 5 mg
Atrial Natriuretic Peptide (ANP) (1-28), rat Avanafil (Atrial natriuretic factor (1-28) (rat)) Cat. No.: HY-P1236 (TA1790) Cat. No.: HY-18252
Bioactivity: Atrial Natriuretic Peptide (ANP) (1-28), rat is a major Bioactivity: Avanafil(TA-1790) is a potent and highly selective circulating form of ANP in rats, potently inhibits Angiotensin phosphodiesterase-5(PDE-5) inhibitor(IC50=5.2 nM) for erectile II (Ang II)-stimulated endothelin-1 secretion in a dysfunction; lower selectivity against PDE1, PDE6, and PDE11. concentration-dependent manner.
Purity: 95.52% Purity: 98.28% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 500u g, 1 mg, 5 mg 50 mg, 100 mg, 500 mg
10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
AVE 0991 AVE 0991 sodium salt Cat. No.: HY-15778 Cat. No.: HY-15778A
Bioactivity: AVE 0991 is a nonpeptide and orally active Ang-(1-7) receptor Bioactivity: AVE 0991 sodium salt is a nonpeptide and orally active Mas agonist. AVE 0991 competes for high-affinity binding of Ang-(1-7) receptor Mas agonist. AVE 0991 competes for [ 125I]-Ang-(1-7) to bovine aortic endothelial cell membranes high-affinity binding of [ 125I]-Ang-(1-7) to bovine aortic
with IC50 of 21±35 nM. endothelial cell membranes with IC50 of 21±35 nM. Purity: 99.16% Purity: 99.32% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
AVE-3085 Avosentan Cat. No.: HY-19504 (Ro 67-0565; SPP-301) Cat. No.: HY-15195
Bioactivity: AVE-3085 is a potent endothelial nitric oxide synthase Bioactivity: Avosentan(Ro 67-0565; SPP-301) is a potent, selective enhancer, used for cardiovascular disease treatment. endothelin receptor(ETA receptor) antagonist.
Purity: 99.0% Purity: 98.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
Azaindole 1 AZD1283 (ROCK inhibitor; TC-S 7001) Cat. No.: HY-10319 Cat. No.: HY-15799
Bioactivity: Azaindole 1 is a highly potent inhibitor of human ROCK-1 and Bioactivity: AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11 nM. ROCK-2, with IC50s of 0.6 and 1.1nM, respectively, and also
inhibits murine ROCK-2 or rat ROCK-2 with IC50s of 2.4 and 0.8nM, respectively. Purity: 98.43% Purity: 99.11% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
Azelnidipine Azilsartan (CS 905) Cat. No.: HY-B0023 (TAK-536) Cat. No.: HY-14914
Bioactivity: Azelnidipine(CS 905; Calblock) is a novel dihydropyridine Bioactivity: Azilsartan(TAK-536) is a specific and potent angiotensin II derivative, a L-type calcium channel blocker, and an type 1 receptor antagonist with IC50 of 2.6 nM. antihypertensive.
Purity: 99.35% Purity: 99.58% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg, 100 mg
Azilsartan medoxomil Azilsartan medoxomil monopotassium (TAK-491) Cat. No.: HY-14736 (Azilsartan kamedoxomil; TAK 491 monopotassium) Cat. No.: HY-17458
Bioactivity: Azilsartan medoxomil(TAK 491) is an orally administered Bioactivity: Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential nM, which used in the treatment of adults with essential hypertension. hypertension.
Purity: >98% Purity: 95.35% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 11
Azimilide Azimilide Dihydrochloride (NE-10064) Cat. No.: HY-18600 (NE-10064 Dihydrochloride) Cat. No.: HY-18600A
Bioactivity: Azimilide(NE-10064) is a class III antiarrhythmic compound, Bioactivity: Azimilide 2Hcl(NE-10064 2Hcl) is a class III antiarrhythmic inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac I(Ks) (minK) channels expressed in Xenopus oocytes. myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. IC50 value: Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2… Purity: >98% Purity: 98.35% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
BAR501 Bay-K-8644 ((R)-(+)-) Cat. No.: HY-101274 ((R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644) Cat. No.: HY-15125
Bioactivity: BAR501 is a potent and selective agonist of GPBAR1 with an Bioactivity: Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. EC of 1 μM. 2+ 50 Bay-K-8644 (R)-(+)- inhibits Ba currents ( IBa) ( IC50=975 nM).
Purity: 98.82% Purity: 98.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg
Bay-K-8644 ((S)-(-)-) Benazepril ((S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644) Cat. No.: HY-15124 Cat. No.: HY-B0093
Bioactivity: Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bioactivity: Benazepril, an angiotensin converting enzyme inhibitor, which 2+ is a medication used to treat high blood pressure. Bay-K-8644 (S)-(-)- activates Ba currents ( IBa) (
EC50=32 nM).
Purity: 98.34% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 5 mg, 10 mg, 50 mg
Benazepril hydrochloride Bendazol (CGS14824A) Cat. No.: HY-B0093A Cat. No.: HY-B2141
Bioactivity: Benazepril hydrochloride, an angiotensin converting enzyme Bioactivity: Bendazol is a hypotensive drug which can also enhance NO inhibitor, which is a medication used to treat high blood synthase activity in renal glomeruli and collecting tubules. pressure. Target: angiotensin converting enzyme (ACE) Benazepril hydrochloride is a medication used to treat high blood pressure (hypertension), congestive heart failure, and… Purity: 99.85% Purity: 99.45% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg, 500 mg, 1 g
Benidipine hydrochloride Benzamil hydrochloride (KW-3049) Cat. No.: HY-B1448 (Benzylamiloride hydrochloride) Cat. No.: HY-B1546A
Bioactivity: Benidipine hydrochloride is a dihydropyridine calcium channel Bioactivity: Benzamil hydrochloride is a specific blocker of sodium blocker for the treatment of high blood pressure channel ( ENaC). (hypertension).
Purity: 99.96% Purity: 99.46% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Benzcyclane Benzofurodil (Bencyclane; Benzcyclan) Cat. No.: HY-U00134 (Benfurodil; CB4091; Eudilat) Cat. No.: HY-U00209
Bioactivity: Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation Bioactivity: Benzofurodil is a cardiotonic, which is used for the chronic inhibitor and a vasodilator effective in a variety of treatment of congestive heart failure. peripheral circulation disorders.
Purity: 99.39% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg
Benzophenonetetracarboxylic acid Benzoylpaeoniflorin (Benzophenone-3,3',4,4'-tetracarbonic acid) Cat. No.: HY-100511 Cat. No.: HY-N0852
Bioactivity: Benzophenonetetracarboxylic acid can inprove activity and Bioactivity: Benzoylpaeoniflorin is a natural product; may treat coronary stability of alkaline phosphatases from psychrophilic and heart disease by decreasing apoptosis. mesophilic organisms. Benzophenonetetracarboxylic acid can improve activity and stability of alkaline phosphatases from psychrophilic and mesophilic organisms by chemically modifying… Purity: 98.0% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg
Benzo[b]thiophene-2-carboximidamide, Bepridil hydrochloride 4-fluoro-N-hydroxy-5,6-dimethoxy- Cat. No.: HY-101729 (CERM 1978) Cat. No.: HY-103315 Bioactivity: Benzo[b]thiophene-2-carboximidamide, Bioactivity: Bepridil hydrochloride is a calcium channel blocker, with 4-fluoro-N-hydroxy-5,6-dimethoxy- is an orally available antianginal activity. compound suitable for the treatment of heart failure without inducing nausea, vomiting and restlessness.
Purity: >98% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg
Betaxolol Betaxolol hydrochloride Cat. No.: HY-B0381 (SL75212) Cat. No.: HY-B0381A
Bioactivity: Betaxolol is a selective beta1 adrenergic receptor blocker Bioactivity: Betaxolol Hydrochloride is a selective beta1 adrenergic used in the treatment of hypertension and glaucoma. receptor blocker used in the treatment of hypertension and glaucoma.
Purity: 96.95% Purity: 98.94% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Betrixaban Bezafibrate (PRT054021) Cat. No.: HY-10268 (BM15075) Cat. No.: HY-B0637
Bioactivity: Betrixaban is a highly potent, selective, and orally Bioactivity: Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 efficacious factor Xa (fXa) inhibitor with IC 50 of 1.5 nM. μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
Purity: 98.85% Purity: 99.05% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg
www.MedChemExpress.com 13
BGP-15 BIBS 39 Cat. No.: HY-100828 Cat. No.: HY-19732
Bioactivity: BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and Bioactivity: BIBS 39 is a new nonpeptide angiotensin II (AII) receptor 57 μM, respectively. antagonist.
Purity: 98.0% Purity: 99.36% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg
Bilirubin Bimoclomol Cat. No.: HY-N0323 Cat. No.: HY-U00398
Bioactivity: Bilirubin is a yellow breakdown product of heme catabolism. Bioactivity: Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg
Bivalirudin Trifluoroacetate BIX 02565 (Bivalirudin) Cat. No.: HY-15664 Cat. No.: HY-16104
Bioactivity: Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide Bioactivity: BIX 02565 is a potent ribosomal S6 kinase 2 ( RSK2) inhibitor which reversibly inhibits thrombin. with IC50 of 1.1 nM.
Purity: 99.76% Purity: 98.48% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
BMS-309403 BMS-654457 Cat. No.: HY-101903 Cat. No.: HY-12631
Bioactivity: BMS-309403 is a potent, selective and cell-permeable inhibitor Bioactivity: BMS-654457 is a small-molecule, reversible inhibitor of factor
of fatty acid binding protein 4 ( FABP4) with a Ki of less XIa ( FXIa), binding with human and rabbit FXIa with Kis of 0.2 than 2 nM. and 0.42 nM, respectively.
Purity: 99.05% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg
BMS-687453 BMS-690514 Cat. No.: HY-10678 Cat. No.: HY-10333
Bioactivity: BMS-687453 is a potent and selective PPARα agonist, with an Bioactivity: BMS-690514 is a potent and orally active inhibitor of EGFR
EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation HER 4, respectively. assays.
Purity: 99.70% Purity: 99.37% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 50 mg
14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
BMS-813160 BNP-45 rat Cat. No.: HY-109593 (Brain natriuretic peptide-45 rat) Cat. No.: HY-P1573
Bioactivity: BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Bioactivity: BNP-45 (rat), a 45-amino acid brain natriurctic peptide clinical development for cardiovascular. isolated from rat heart, is a circulating hormone, with natriuretic and hypotensive activities.
Purity: 99.81% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Bometolol Hydrochloride Bosentan Cat. No.: HY-U00386 (Benzenesulfonamide) Cat. No.: HY-A0013
Bioactivity: Bometolol Hydrochloride is a beta-adrenergic blocking agent, Bioactivity: Bosentan is a competitive and dual antagonist of endothelin-1
used for the research of cardiovascular disease. (ET) for the ET A and ET B receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.
Purity: >98% Purity: 99.69% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg
Bosentan hydrate BQ-788 (Benzenesulfonamide) Cat. No.: HY-A0013A Cat. No.: HY-15894A
Bioactivity: Bosentan hydrate is a competitive and dual antagonist of Bioactivity: BQ-788 is a potent, selective ETB receptor antagonist with endothelin-1 (ET) for the ET and ET receptors with K of A B i IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi 4.7 nM and 95 nM in human SMC, respectively. heart cells, poorly inhibiting the binding to ETA receptors in
human neuroblastoma cell line SK-N-MC cells with IC50 of 1… Purity: 99.94% Purity: >98% Clinical Data: Launched Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 5 g
BQ-788 sodium salt Bradykinin Cat. No.: HY-15894 Cat. No.: HY-P0206
Bioactivity: BQ-788 (sodium salt) is a potent and selective ETB receptor Bioactivity: Bradykinin is an active peptide that is generated by the antagonist, inhibiting ET-1 binding to ETB receptors with an kallikrein-kinin system. It is a inflammatory mediator and
IC50 of 1.2 nM in human Girrardi heart cells. also recognized as a neuromediator and regulator of several vascular and renal functions. Sequence: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg. Purity: 98.08% Purity: 98.97% Clinical Data: Phase 1 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg
Bradykinin 1-3 Bradykinin 1-5 Cat. No.: HY-P1497 Cat. No.: HY-P1488
Bioactivity: Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin Bioactivity: Bradykinin (1-5) is a major stable metabolite of Bradykinin, (1-3) is an amino-truncated Bradykinin peptide, cleaved by formed by the proteolytic action of angiotensin-converting Prolyl endopeptidase. enzyme (ACE).
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg
www.MedChemExpress.com 15
Bradykinin 1-6 Bradykinin 1-7 Cat. No.: HY-P1469 (Bradykinin Fragment 1-7) Cat. No.: HY-P1484
Bioactivity: Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bioactivity: Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by by carboxypeptidase Y (CPY). endopeptidase.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 5 mg, 10 mg
Bradykinin 2-9 Brain Natriuretic Peptide (BNP) (1-32), human (Des-Arg1-bradykinin) Cat. No.: HY-P1490 (Nesiritide Acetate (BNP-32)) Cat. No.: HY-P1472
Bioactivity: Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bioactivity: Brain Natriuretic Peptide (BNP) (1-32), human is a 32-amino Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by acid peptide, and plays an important role in cardiovascular Aminopeptidase P. homeostasis.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg
Brain Natriuretic Peptide (BNP) (1-32), rat BRL 54443 Cat. No.: HY-P1519 Cat. No.: HY-13221
Bioactivity: Brain Natriuretic Peptide (BNP) (1-32), rat is a 32 amino acid Bioactivity: BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values polypeptide secreted by the ventricles of the heart in are 8.7 and 8.9 respectively); displays > 30-fold response to excessive stretching of heart muscle cells selectivity over other 5-HT and dopamine receptors. (cardiomyocytes).
Purity: >98% Purity: 98.86% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
Bromindione Bumetanide (Fluidane; Halinone) Cat. No.: HY-B0917 (Ro 10-6338; PF 1593) Cat. No.: HY-17468
Bioactivity: Bromindione is a potent, long-acting, inandione-derived, oral Bioactivity: Bumetanide(Ro 10-6338; PF 1593) is an inhibitor of anticoagulant compound. Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.
Purity: >98% Purity: 99.91% Clinical Data: No Development Reported Clinical Data: Launched Size: 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g
Bunaftide BW 245C (Bunaftine; Bunaphtide; Meregon) Cat. No.: HY-U00113 Cat. No.: HY-101987
Bioactivity: Bunaftide (Bunaftine; Bunaphtide; Meregon) is an Bioactivity: BW 245C is a prostanoid DP-receptor (DP1) agonist, used to antiarrhythmic agent. treat stroke.
Purity: >98% Purity: 99.14% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg
16 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
C-Type Natriuretic Peptide (CNP) (1-22), human C80-1324 Cat. No.: HY-P1237 (2-oxide; Ipramidil) Cat. No.: HY-U00172
Bioactivity: C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 Bioactivity: C80-1324 is a furoxan compound. C80-1324 reveals marked fragment of C-Type Natriuretic Peptide. C-type natriuretic dilator activity in the coronary circulation of isolated peptide is natriuretic peptide family peptide that is involved working hearts. in the maintenance of electrolyte-fluid balance and vascular tone. Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Calcium channel-modulator-1 Caldaret Cat. No.: HY-U00135 (MCC-135) Cat. No.: HY-100298
Bioactivity: Calcium channel-modulator-1 is a calcium channel modulator; Bioactivity: Caldaret is an intracellular Ca2+ handling modulator that blocks aortic contraction with an IC of 0.8 μM. 50 acts through reverse mode Na+/ Ca2+ exchanger inhibition.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg
Candesartan Candesartan Cilexetil (CV 11974) Cat. No.: HY-B0205 (TCV-116) Cat. No.: HY-17505
Bioactivity: Candesartan is an angiotensin II receptor antagonist with IC50 Bioactivity: Candesartan Cilexetil (TCV-116) is an angiotensin II receptor of 0.26 nM. antagonist used mainly for the treatment of hypertension.
Purity: 96.20% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 500 mg, 1 g
Canrenone Capadenoson (Aldadiene; SC9376; SC14266) Cat. No.: HY-B1438 (BAY 68-4986) Cat. No.: HY-14917
Bioactivity: Canrenone (Aldadiene; SC9376; SC14266) is an aldosterone Bioactivity: Capadenoson is a selective agonist of adenosine-A1 receptor. antagonist extensively used as a diuretic agent.
Purity: 99.16% Purity: 98.43% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
Carbacyclin Carbazochrome sodium sulfonate (Carbaprostacyclin; Carba-PGI2) Cat. No.: HY-112322 Cat. No.: HY-B0491A
Bioactivity: Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) Bioactivity: Carbazochrome(AC-17) is an antihemorrhagic agent. Target: receptor agonist and vasodilator, and potently inhibits Others Carbazochrome is an antihemorrhagic agent that will platelet aggregation. cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be… Purity: 99.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg
www.MedChemExpress.com 17
Cardiogenol C hydrochloride Cariporide Cat. No.: HY-12319A (HOE-642) Cat. No.: HY-19693
Bioactivity: Cardiogenol C hydrochloride is a cell-permeable pyrimidine Bioactivity: Cariporide (HOE-642) is a selective Na+/H+ exchange compound which potently induces the differentiation of ESCs inhibitor. into cardiomyocytes (EC50= 100 nM).
Purity: 96.22% Purity: 98.57% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
Carteolol hydrochloride Carvedilol phosphate hemihydrate Cat. No.: HY-17495A Cat. No.: HY-B0006A
Bioactivity: Carteolol HCl is a non-selective beta blocker used to treat Bioactivity: Carvedilol is a non-selective beta blocker/alpha-1 blocker glaucoma. with an IC50 of 3.8 μM for inhibition of LDL oxidation. IC50 Value: 3.8 μM ( inhibition of LDL oxidation) Target: beta Adrenergic Receptor Carvedilol is a nonselective-blocking agent and is used in the treatment of hypertension and angina… Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 50 mg, 100 mg
CAY 10465 CB-7921220 Cat. No.: HY-112627 Cat. No.: HY-101862
Bioactivity: CAY 10465 is a selective and high-affinity AhR agonist, with Bioactivity: CB-7921220 is an adenylate cyclase inhibitor.
a Ki of 0.2 nM, and shows no effect on estrogen receptor (K i >100000 nM).
Purity: 98.48% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg
CB1 antagonist 1 CE-245677 Cat. No.: HY-U00397 Cat. No.: HY-112423
Bioactivity: CB1 antagonist 1 is an antagonist of CB1 receptor, used in Bioactivity: CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B
the research of metabolic syndrome and obesity, kinases with a cellular IC50s of 4.7 and 1 nM. neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 250 mg, 500 mg
Ceruletide CGP48369 (Caerulein; Cerulein) Cat. No.: HY-A0190 Cat. No.: HY-101706
Bioactivity: Ceruletide, a biologically active decapeptide isolated from Bioactivity: CGP48369 is a nonpeptidic angiotensin II receptor antagonist, the skin of the Australian frog Hyla caerulea, is a potent used for anti-hypertensive research. cholecystokinetic agent, and acts as a cholecystokinin receptor agonist.
Purity: 99.96% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg
18 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
CGRP antagonist 1 Chlorindione Cat. No.: HY-112262 (Chlophenadione; Indaliton; G-25766) Cat. No.: HY-B0918
Bioactivity: CGRP antagonist 1 is a highly potent CGRP receptor Bioactivity: Chlophenadione is a potent anticoagulant compound.
antagonist with a Ki and IC50 of 35 and 57 nM, respectively.
Purity: >98% Purity: 97.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg
Chlorothiazide Chlorthalidone Cat. No.: HY-B0224 Cat. No.: HY-15833
Bioactivity: Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 Bioactivity: Chlorthalidone is a thiazide-like diuretic used to treat mM) hypertension.
Purity: 98.75% Purity: 98.85% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg
Choline Fenofibrate Chroman 1 (ABT-335) Cat. No.: HY-14739 (ROCK-II inhibitor) Cat. No.: HY-15392
Bioactivity: Choline Fenofibrate (ABT-335) is the choline salt of Bioactivity: Chroman 1 is a highly potent ROCK2 inhibitor, with an IC50 of fenofibric acid under clinical development as a combination < 1 nM. therapy with rosuvastatin for the management of dyslipidemia.
Purity: 99.81% Purity: 99.76% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 100 mg 5 mg, 10 mg
Chromocarb Cicloprolol hydrochloride (Chromone-2-carboxylic acid) Cat. No.: HY-B1182 Cat. No.: HY-U00066
Bioactivity: Chromocarb is a synthetic vasoprotectant. Bioactivity: Cicloprolol is a partial β 1-adrenoceptor agonist .
Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg
Cilazapril Cilazapril monohydrate (Ro 31-2848) Cat. No.: HY-A0043 (Ro 31-2848 monohydrate) Cat. No.: HY-A0043A
Bioactivity: Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor Bioactivity: Cilazapril Monohydrate is a angiotensin-converting enzyme used for the treatment of hypertension and congestive heart (ACE) inhibitor used for the treatment of hypertension and failure. congestive heart failure.
Purity: >98% Purity: 98.63% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 19
Cilnidipine Cilobradine hydrochloride (FRC-8653) Cat. No.: HY-17404 (DK-AH 269) Cat. No.: HY-18940A
Bioactivity: Cilnidipine(FRC8653) is a dual L- and N-type calcium channel Bioactivity: Cilobradine is an HCN Channel blocker; an open channel blocker blocker and displays antihypertensive, sympatholytic and of neuronal Ih and related cardiac If channels. Target: HCN neuroprotective activity. Channel blocker Cilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ±… Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 2 mg 10 mg, 50 mg, 100 mg
Cilostamide Cilostazol (OPC3689) Cat. No.: HY-101312 (OPC 13013; OPC 21) Cat. No.: HY-17464
Bioactivity: Cilostamide is a selective and potent PDE3 inhibitor, with Bioactivity: Cilostazol(OPC 13013; OPC 21) is a potent inhibitor of PDE3A, the isoform of PDE 3 in the cardiovascular system (IC50=0.2 IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. uM). IC50 Value: 0.2 uM [1] Target: PDE3A in vitro: Cilostazol caused a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Furthermore,… Purity: 99.63% Purity: 99.34% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 50 mg, 100 mg
Cinacalcet Cinacalcet hydrochloride (AMG 073) Cat. No.: HY-70037 (AMG-073 hydrochloride; Cinacalcet) Cat. No.: HY-70037A
Bioactivity: Cinacalcet is an orally active, allosteric agonist of Ca Bioactivity: Cinacalcet hydrochloride is an orally active, allosteric receptor (CaR), used for cardiovascular disease treatment. agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Purity: 99.65% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg, 100 mg
Cinaciguat Cinaciguat hydrochloride (BAY 58-2667) Cat. No.: HY-14181 (BAY 58-2667 hydrochloride) Cat. No.: HY-14181A
Bioactivity: Cinaciguat is an activator of guanylate cyclase (sGC), and Bioactivity: Cinaciguat hydrochloride is a potent soluble guanylate cyclase (
used for acute decompensated heart failure. GC) activator with EC50 of 15 nM in platelets.
Purity: 99.40% Purity: 98.0% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg 2 mg, 5 mg, 10 mg, 50 mg
Cinepazide Cinepazide Maleate Cat. No.: HY-66010A Cat. No.: HY-66010
Bioactivity: Cinepazide is a vasodilator. Target: Others Cinepazide is a Bioactivity: Cinepazide Maleate is a vasodilator. Target: Others Cinepazide vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the maleate is a maleate salt form of cinepazide which is a vertebral vasodilator response of dogs to intravertebral vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) vertebral vasodilator response of dogs to intravertebral increased vertebral blood flow in a dose-related manner and… adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg)… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg
20 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Cinnarizine Citric acid Cat. No.: HY-B1090 Cat. No.: HY-N1428
Bioactivity: Cinnarizine is an antihistamine and a calcium channel blocker, Bioactivity: Citric acid is a weak organic tricarboxylic acid found in promote cerebral blood flow, used to treat cerebral apoplexy, citrus fruits. Citric acid is a natural preservative and food post-trauma cerebral symptoms, and cerebral arteriosclerosis. tartness enhancer.
Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg
Cladribine Clevidipine (2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA) Cat. No.: HY-13599 Cat. No.: HY-17436
Bioactivity: Cladribine is an adenosine deaminase inhibitor used to treat Bioactivity: Clevidipine is a short-acting dihydropyridine calcium channel hairy cell leukemia and multiple sclerosis. antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension. IC50 Value: 7.1 nM at V(H) = -40 mV [1] Target: calcium channel in vitro: Both clevidipine and nitroglycerin completely reversed… Purity: 99.89% Purity: 99.74% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Clonidine hydrochloride Clopidogrel Cat. No.: HY-B0409A Cat. No.: HY-15283
Bioactivity: Clonidine hydrochloride is an agonist of α2-adrenoceptor and Bioactivity: Clopidogrel is a well-known P2Y12 receptor blocker. potent antihypertensive agent.
Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg 100 mg, 500 mg
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate; Clopidogrel thiolactone (S)-(+)-Clopidogrel hydrogen sulfate) Cat. No.: HY-17459 Cat. No.: HY-15876
Bioactivity: Clopidogrel is an antiplatelet agent which works by blocking Bioactivity: Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a platelets from sticking together and prevents them from potent antiplatelet agent. forming harmful clots.
Purity: 97.95% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 50 mg
CNS-5161 hydrochloride Coenzyme Q9 (CNS 5161A) Cat. No.: HY-101809 (Ubiquinone Q9; CoQ9; Ubiquinone 9) Cat. No.: HY-101415
Bioactivity: CNS-5161 hydrochloride is a novel NMDA ion-channel Bioactivity: Coenzyme Q 9, a nine isoprenyl group-containing member of the antagonist that interacts with the NMDA receptor/ion ubiquinone family, is a normal constituent of human plasma. channel site to produce a noncompetitive blockade of the actions of glutamate.
Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg
www.MedChemExpress.com 21
Colestyramine Complanatuside (Cholestyramine resin; cholestyramine) Cat. No.: HY-104081 Cat. No.: HY-N1444
Bioactivity: Colestyramine (Cholestyramine) is a bile acid binding resin Bioactivity: Complanatuside is a flavonoid found in the traditional Chinese and can inhibit intestinal bile acid absorption which results medicine Semen Astragali Complanati. in the increasing bile acid synthesis from cholesterol.
Purity: Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 g Size: 10mM x 1mL in DMSO, 5 mg, 10 mg
Conivaptan hydrochloride Corynoxeine (YM 087) Cat. No.: HY-18347A Cat. No.: HY-N0590
Bioactivity: Conivaptan (hydrochloride) is a non-peptide antagonist of Bioactivity: Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is
vasopressin receptor, with Ki values of 0.48 and 3.04 nM for a potent ERK1/ ERK2 inhibitor of key PDGF-BB-induced rat liver V1A receptor and rat kidney V2 receptor vascular smooth muscle cells (VSMCs) proliferation. respectively.
Purity: 99.92% Purity: 99.91% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg
CP-060 CRA-026440 Cat. No.: HY-U00354 Cat. No.: HY-19754
2+ 2+ Bioactivity: CP-060 is a potent Ca antagonist, inhibits Ca Bioactivity: CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The Ki overload and possesses antioxidant and cardioprotective values against recombinant HDAC isoenzymes HDAC1, HDAC2, activities. HDAC3, HDAC6, HDAC8, and HDAC10 are 4, 14, 11, 15, 7, and 20 nM respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Crustacean Cardioactive Peptide CCAP CS476 Cat. No.: HY-P0303 (NSC302998) Cat. No.: HY-U00211
Bioactivity: Crustacean Cardioactive Peptide (CCAP) is a highly conserved, Bioactivity: CS476 is a potent hypoglycaemic agent. amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other… Purity: 98.91% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
CXCR7 modulator 2 Cyclandelate Cat. No.: HY-112154 (3,5,5-Trimethylcyclohexyl mandelate) Cat. No.: HY-B1170
Bioactivity: CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Bioactivity: Cyclandelate is a vasodilator used in the treatment of
Type 7 ( CXCR7), with a Ki of 13 nM. claudication, arteriosclerosis, and Raynaud's disease. It is also used to treat nighttime leg cramps, and has been investigated for its effect against migraine.
Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 50 mg
22 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
CYM-5541 Dabigatran (ML249) Cat. No.: HY-101419 (BIBR 953; BIBR 953ZW) Cat. No.: HY-10163
Bioactivity: CYM-5541 (ML249) is an selective and allosteric S1P3 Bioactivity: Dabigatran(BIB-953; BIBR 953ZW) is a reversible and selective, receptor agonist with an EC between 72 and 132 nM. direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. IC50 50 Value: 4.5 nM (Ki); 10 nM(Thrombin-induced platelet aggregation) [1] Target: thrombin in vitro: Dabigatran selectively and reversibly inhibited human thrombin(Ki: 4.5… Purity: 98.0% Purity: 96.12% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Dabigatran etexilate Dabigatran etexilate mesylate (BIBR 1048) Cat. No.: HY-10274 (BIBR 1048MS; Dabigatran etexilate methanesulfonate) Cat. No.: HY-10274A
Bioactivity: Dabigatran etexilate(BIBR-1048) is the orally active prodrug Bioactivity: Dabigatran etexilate mesylate (BIBR 1048MS) is the orally of dabigatran; Dabigatran is a reversible and selective, active prodrug of dabigatran. Dabigatran is a reversible and direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
Purity: 99.37% Purity: 99.60% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Dabigatran ethyl ester Dabigatran ethyl ester hydrochloride Cat. No.: HY-17378 Cat. No.: HY-77521
Bioactivity: ethyl ester of Dabigatran, which is an emerging oral Bioactivity: Dabigatran ethyl ester hydrochloride is a potent inhibitor of
anticoagulant which is a direct inhibitor of thrombin ribosyldihydronicotinamide dehydrogenase ( NQO2) with an IC50 activity. value of 0.8 μM and a thrombin inhibitor.
Purity: 99.26% Purity: 99.36% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
Dalcetrapib Danegaptide (JTT-705; RO4607381) Cat. No.: HY-14950 (GAP-134; ZP 1609) Cat. No.: HY-10913
Bioactivity: Dalcetrapib (JTT-705; RO-4607381) is a rhCETP inhibitor with Bioactivity: GAP-134 (Danegaptide, ZP 1609), a small modified dipeptide, IC50 of 0.2 μM that increases the plasma HDL cholesterol. has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. IC50 value: Target: gap junction Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry… Purity: 99.46% Purity: >98% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
Danshensu Daphylloside (Dan shen suan A; Salvianic acid A) Cat. No.: HY-N1913 Cat. No.: HY-N6245
Bioactivity: Danshensu, an active ingredient of Salvia Bioactivity: Daphylloside is an iridoid isolated from the aerial parts of miltiorrhiza, shows wide cardiovascular benefit by Galium verum. activating Nrf2 signaling pathway.
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 23
Daprodustat Darapladib (GSK1278863) Cat. No.: HY-17608 (SB-480848) Cat. No.: HY-10521
Bioactivity: Daprodustat (GSK1278863) is an orally active hypoxia-inducible Bioactivity: Darapladib is a potent inhibitor of lipoprotein-associated
factor prolyl hydroxylase inhibitor being developed for the phospholipase A2 ( Lp-PLA2) with IC50 of 0.25 nM. treatment of anemia associated with chronic kidney disease.
Purity: 99.95% Purity: 99.95% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg
Darodipine Deferiprone (PY 108-068; PY-108068) Cat. No.: HY-U00086 Cat. No.: HY-B0568
Bioactivity: Darodipine (PY 108-068, PY-108068) is a potent calcium Bioactivity: Deferiprone is the only orally active iron-chelating drug to channel antagonist. be used therapeutically in conditions of transfusional iron overload.
Purity: >98% Purity: 99.15% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg Size: 10mM x 1mL in DMSO, 5 g
Delcasertib Desethyl KBT-3022 (KAI-9803; BMS-875944) Cat. No.: HY-106262 Cat. No.: HY-U00039
Bioactivity: KAI-9803 is a potent and selective δ-protein kinase C ( δPKC) Bioactivity: Desethyl KBT-3022 is the main active metabolite of the new inhibitor. antiplatelet agent, KBT-3022.
Purity: 95.38% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg
Desidustat Dexrazoxane Cat. No.: HY-103227 (ICRF187; NSC169780) Cat. No.: HY-B0581
Bioactivity: Desidustat is an inhibitor of HIF hydroxylase extracted from Bioactivity: Dexrazoxane(ICRF187) is a cardioprotective agent. patent WO 2014102818 A1, compound example 2.
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg
Dexrazoxane Hydrochloride DHBP dibromide (ICRF-187 hydrochloride) Cat. No.: HY-76201 (Diheptylviologen dibromide) Cat. No.: HY-101237
Bioactivity: Dexrazoxane Hcl( ICRF-187 Hcl) is a cardioprotective agent. Bioactivity: DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
Purity: 99.75% Purity: 99.56% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 100 mg
24 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Diazoxide Digitoxin (Sch-6783; SRG-95213) Cat. No.: HY-B1140 Cat. No.: HY-B1357
Bioactivity: Diazoxide is an ATP-sensitive potassium channel activator ; Bioactivity: Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 can be used to treat hyperinsulinism. value of Digitoxin is 0.78 μM.
Purity: 99.76% Purity: 98.23% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg
Digoxin Dihydrotanshinone I (12β-Hydroxydigitoxin) Cat. No.: HY-B1049 Cat. No.: HY-N0360
Bioactivity: Digoxin is a potent inhibitor of Na+/K+-ATPase, clinically Bioactivity: Dihydrotanshinone I is a natural compound extracted from Salvia used to treat arrhythmia and heart failure. miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases.
Purity: 98.46% Purity: 99.59% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 10 mg, 25 mg, 50 mg
Diltiazem hydrochloride Diosmin (CRD-401) Cat. No.: HY-14656 Cat. No.: HY-N0178
Bioactivity: Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow Bioactivity: Diosmin is a flavonoid found in a variety of citrus fruits and channel blocker or calcium antagonist). also an agonist of the aryl hydrocarbon receptor ( AhR).
Purity: 98.39% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 g, 5 g 50 mg
Dipyridamole DL-Borneol Cat. No.: HY-B0312 ((±)-Borneol) Cat. No.: HY-N1368
Bioactivity: Dipyridamole (Persantine) is a phosphodiesterase inhibitor Bioactivity: DL-Borneol is a racemic mixture of D-Borneol and L-Borneol. that blocks uptake and metabolism of adenosine by erythrocytes DL-Borneol is widely used for the treatment of cardiovascular and vascular endothelial cells. and cerebrovascular diseases in China.
Purity: 98.02% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 1 g, 5 g
Dobutamine hydrochloride Docosatrienoic Acid (cis-13,16,19-docosatrienoic acid; Cat. No.: HY-15746 (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid) Cat. No.: HY-101408
Bioactivity: Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in the Bioactivity: Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4
treatment of heart failure and cardiogenic shock. Its primary binding to pig neutrophil membranes with an Ki of 5 μM. mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.
Purity: 99.78% Purity: 98.00% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Ethanol, 100 mg 5 mg, 10 mg
www.MedChemExpress.com 25
Dofetilide Dopexamine hydrochloride (UK 68789) Cat. No.: HY-B0232 (FPL60278AR) Cat. No.: HY-U00205
Bioactivity: Dofetilide(Tikosyn) is a class III antiarrhythmic agent. Bioactivity: Dopexamine hydrochloride is a β2 adrenergic receptor agonist.
Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg 5 mg, 10 mg, 50 mg
Dopropidil Doxazosin Cat. No.: HY-U00151 (UK 33274) Cat. No.: HY-B0098
Bioactivity: Dopropidil is a novel anti-anginal calcium ion modulating Bioactivity: Doxazosin(UK 33274) is a quinazoline-derivative that agent, possessing intracellular calcium antagonist activity selectively antagonizes postsynaptic α1-adrenergic receptors. and anti-ischemic effects in several predictive animal models.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 100 mg, 500 mg
Doxazosin mesylate Drobuline hydrochloride (UK 33274 mesylate) Cat. No.: HY-B0098A Cat. No.: HY-U00149
Bioactivity: Doxazosin mesylate(UK 33274) is a quinazoline-derivative that Bioactivity: Drobuline hydrochloride is an anti-arrhythmic agent with selectively antagonizes postsynaptic α1-adrenergic receptors. cardiac depressant. Target: α1-adrenergic receptor Doxazosin (mesylate) is the mesylate salt form of doxazosin, which is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat… Purity: 98.60% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 500 mg, 1 g
Dronedarone Dronedarone Hydrochloride Cat. No.: HY-A0016 Cat. No.: HY-75839
Bioactivity: Dronedarone(Multaq) is a newer therapeutic agent with a Bioactivity: Dronedarone hydrochloride is a non-iodinated amiodarone structural resemblance to amiodarone and a better side effect derivative that inhibits Na+, K+ and Ca2+ currents. profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF. IC50 value:… Purity: 99.49% Purity: 99.68% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg
Droxicainide DS-1040 Tosylate Cat. No.: HY-101617 Cat. No.: HY-101918
Bioactivity: Droxicainide is an antiarrhythmic agent. Bioactivity: DS-1040 Tosylate is an inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa), used for the treatment of acute ischemic stroke (AIS).
Purity: >98% Purity: 99.67% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg
26 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
DU717 E-4031 Cat. No.: HY-U00182 Cat. No.: HY-15551
Bioactivity: DU-717 is an antihypertensive agent. Bioactivity: E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel.
Purity: >98% Purity: 98.03% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
Ecastolol Edoxaban Cat. No.: HY-101691 (DU-176) Cat. No.: HY-10264
Bioactivity: Ecastolol is a beta adrenergic receptor antagonist, with Bioactivity: Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in antianginal activities. clinical development for stroke prevention
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg, 100 mg
Edoxaban tosylate Edoxaban tosylate monohydrate (DU-176b) Cat. No.: HY-10264A Cat. No.: HY-10264B
Bioactivity: Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in Bioactivity: Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention IC50 Value: Target: clinical development for stroke prevention factor Xa Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention in patients with atrial fibrillation, an elderly population that frequently… Purity: >98% Purity: 99.85% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
Efloxate Efonidipine (Angorlisin) Cat. No.: HY-B0930 (NZ-105; (±)-Efonidipine) Cat. No.: HY-12502
Bioactivity: Efloxate is a vasodilator, used to treat chronic coronary Bioactivity: Efonidipine(NZ-105) is a dual T-type and L-type calcium insufficiency and Angina pectoris, channel blocker (CCB). IC50 value: Target: calcium channel blocker in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate… Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 50 mg Size: 10 mg, 50 mg
Efonidipine hydrochloride Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride) Cat. No.: HY-12502B (NZ-105 hydrochloride monoethanolate) Cat. No.: HY-12502A
Bioactivity: Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium Bioactivity: Efonidipine(NZ-105) Hcl monoethanolate is a dual T-type and channel blocker (CCB). L-type calcium channel blocker (CCB).
Purity: >98% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
www.MedChemExpress.com 27
Elisartan Eltrombopag (HN 65021) Cat. No.: HY-19214 (SB-497115; SB-497115-GR) Cat. No.: HY-15306
Bioactivity: Elisartan is an orally active non-peptide pro-drug of Bioactivity: Eltrombopag is a thrombopoietin (TPO) receptor agonist angiotensin II AT1 receptor antagonist HN-12206, and shows developed for certain conditions that lead to anti-hypertension activities. thrombocytopenia.
Purity: >98% Purity: 98.41% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg
Eltrombopag Olamine EML 425 (Eltrombopag diethanolamine salt; SB-497115GR) Cat. No.: HY-15306A Cat. No.: HY-110263
Bioactivity: Eltrombopag is a thrombopoietin-receptor agonist used to Bioactivity: EML425 is a potent and selective CREB binding protein ( CBP)/
treat low blood platelet counts with chronic immune p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively. thrombocytopenia.
Purity: 99.56% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg
Enalapril Enalapril maleate Cat. No.: HY-B0331 Cat. No.: HY-B0331A
Bioactivity: Enalapril is an angiotensin converting enzyme (ACE) inhibitor. Bioactivity: Enalapril Maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.
Purity: >98% Purity: 99.96% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 1 g, 5 g
Enalaprilat dihydrate Endothelin-2, human Cat. No.: HY-B0231 (Endothelin-2 (human, canine); Human endothelin-2) Cat. No.: HY-P0207
Bioactivity: Enalaprilat is an angiotensin-converting enzyme (ACE) Bioactivity: Endothelin-2, human is a 21-amino acid vasoactive peptide that inhibitor with IC50 of 1.94 nM. Target: ACE Enalaprilat has binds to G-protein-linked transmembrane receptors, ET-RA and high affinity for human endothelial ACE with IC50 of 1.94 nM ET-RB. in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril… Purity: 99.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg 50 mg, 100 mg
Endothelin-3, human, mouse, rabbit, rat Enecadin (Endothelin 3 (Rat,Human)) Cat. No.: HY-P0204 Cat. No.: HY-100119
Bioactivity: Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid Bioactivity: Enecadin is a neuroprotective agent extracted from patent US vasoactive peptide that binds to G-protein-linked 8623823 B2. transmembrane receptors, ET-RA and ET-RB.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg
28 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Eniporide hydrochloride EPAC 5376753 (EMD-96785 hydrochloride) Cat. No.: HY-106150B Cat. No.: HY-111446
Bioactivity: Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Bioactivity: EPAC 5376753 is an allosterically inhibitor of Epac which + + Na /H exchange inhibitor. inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
Purity: 99.31% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg
Eplerenone Eprosartan mesylate (Epoxymexrenone) Cat. No.: HY-B0251 (SKF-108566J) Cat. No.: HY-15834A
Bioactivity: Eplerenone is an aldosterone antagonist with an IC50 of 0.36 Bioactivity: Eprosartan is a nonpeptide angiotensin II receptor antagonist μM. Target: Mineralocorticoid Receptor Eplerenone is a with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical selective mineralocorticoid receptor antagonist, which has membranes, respectively. been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative… Purity: 99.62% Purity: 99.79% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Eptifibatide Esaxerenone (MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2; {MPA}{HAR}GDWPC-NH2)Cat. No.: HY-B0686 (CS-3150; XL-550) Cat. No.: HY-100471
Bioactivity: Eptifibatide is an antiplatelet drug of the glycoprotein Bioactivity: Esaxerenone is a novel, highly potent and selective IIb/IIIa inhibitor class. Target: Others Eptifibatide is an non-steroidal mineralocorticoid receptor antagonist. anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the… Purity: 96.49% Purity: 99.65% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg
Esmolol hydrochloride ETA antagonist 1 Cat. No.: HY-B1392 Cat. No.: HY-112264
Bioactivity: Esmolol Hydrochloride is a beta adrenergic receptor blocker. Bioactivity: ETA antagonist 1 is a ETA selective antagonist with an IC50 Target: Adrenergic receptor Esmolol Hydrochloride is the of 0.08 μM. hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic… Purity: 99.77% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg
Etersalate Ethamsylate (Eterylate; Etherylate) Cat. No.: HY-101606 Cat. No.: HY-B1074
Bioactivity: Etersalate inhibits platelet function and decreases Bioactivity: Ethamsylate is a haemostatic drug, also inhibits biosynthesis thromboxane A2 ( TXA2) levels. and action of those prostaglandins.
Purity: >98% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 29
Etofylline Evacetrapib (7-(β-Hydroxyethyl)theophylline; 7-Theophyllineethanol) Cat. No.: HY-B1209 (LY2484595) Cat. No.: HY-13327
Bioactivity: Etofylline is a vasodilator. Bioactivity: Evacetrapib is a potent and selective of CETP inhibitor,
which inhibits human recombinant CETP protein ( IC50 5.5 nM)
and CETP activity in human plasma ( IC50 36 nM) in vitro.
Purity: 99.89% Purity: 99.33% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
Evatanepag Examorelin (Hexarelin; His-D-2-ME-Trp-Ala-Trp-d-Phe-Lys-NH2; (CP-533536 free acid) Cat. No.: HY-14839 H{D-2-ME-TRP}AW{d-PHE}K-NH2) Cat. No.: HY-19235
Bioactivity: Evatanepag (CP-533536) is an EP2 receptor selective Bioactivity: Examorelin, a synthetic growth hormone-releasing peptide, has prostaglandin E2 (PGE2) agonist that induces local bone been proven to possess cardioprotective actions through its formation with EC50 of 0.3 nM. binding to the growth hormone secretagogue receptor ( GHSR) 1a and the non-GHSR receptor CD36.
Purity: 98.02% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg
Ezetimibe F 16915 Cat. No.: HY-17376 Cat. No.: HY-19886
Bioactivity: Ezetimibe is a Niemann-Pick C1-like1 ( NPC1L1) inhibitor, and Bioactivity: F 16915 is a docosahexaenoic acid derivative which can prevent is a potent Nrf2 activator. Ezetimibe (Eze) is a potent heart failure-induced atrial fibrillation. cholesterol absorption inhibitor.
Purity: 99.76% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 1 mg, 5 mg, 10 mg
FCE 28654 Felodipine Cat. No.: HY-U00369 Cat. No.: HY-B0309
Bioactivity: FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol Bioactivity: Felodipine is a long-acting 1,4-dihydropyridine calcium acyltransferase ( ACAT), weakly inhibiting ACAT in channel blocker. microsomes from rabbit aorta and intestine, and monkey liver,
with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.
Purity: >98% Purity: 99.75% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
Felypressin Fendiline hydrochloride (Octapressin; PLV-2) Cat. No.: HY-A0182 Cat. No.: HY-B0984
Bioactivity: Felypressin is a Vasopressin 1 agonist, and will thus have Bioactivity: Fendiline is a nonselective calcium channel blocker. effects at all Arginine vasopressin receptor 1As.
Purity: 99.64% Purity: 98.94% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg
30 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Fenofibrate Fenoldopam Cat. No.: HY-17356 (SKF 82526) Cat. No.: HY-B0735
Bioactivity: Fenofibrate is a relatively potent inhibitor of CYP2C19 ( Bioactivity: Fenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial IC50=0.2 μM) and CYP2B6 ( IC50=0.7 μM). Fenofibrate is also a agonist. well-known PPARα agonist ( EC50=30 μM).
Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg 5 g, 10 g
Fenoldopam mesylate Ferulic acid sodium (Fenoldopam methanesulfonate; SKF-82526 mesylate) Cat. No.: HY-B0735A (Sodium ferulate) Cat. No.: HY-N0060A
Bioactivity: Fenoldopam(SKF 82526) mesylate is a drug and synthetic Bioactivity: Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic benzazepine derivative which acts as a selective D1 receptor compound present in several plants with claimed beneficial partial agonist. effects in prevention and treatment of disorders linked to oxidative stress and inflammation.
Purity: 99.85% Purity: 99.74% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 g, 5 g
Fibrinogen Binding Inhibitor Peptide Fibrinopeptide A, human Cat. No.: HY-P1507 (Human fibrinopeptide A) Cat. No.: HY-P1538
Bioactivity: Fibrinogen Binding Inhibitor Peptide is a dodecapeptide Bioactivity: Fibrinopeptide A, human is a 16-residue short polypeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain cleaved from fibrinogen by thrombin. Fibrinopeptide A, human
carboxy-terminal sequence (γ400-411). Fibrinogen Binding locates at the NH 2-termini of the Aα chain. Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg
Fibronectin Adhesion-promoting Peptide Fimasartan (Heparin Binding Peptide) Cat. No.: HY-P0306 (BR-A-657) Cat. No.: HY-B0780
Bioactivity: Heparin Binding Peptide is one of the heparin-binding amino Bioactivity: Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor acid Sequence: Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile. antagonist used for the treatment of hypertension and heart failure.
Purity: >98% Purity: 98.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
FKK Flavin Adenin Dinucleotide Cat. No.: HY-100194 (Flavitan; NSC 112207) Cat. No.: HY-B1654
Bioactivity: FKK is an indazole derivative and also a novel bronchodilator. Bioactivity: Flavin Adenin Dinucleotide is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size:
www.MedChemExpress.com 31
Flavin Adenine Dinucleotide Disodium Flecainide acetate (FAD-Na2; FAD sodium salt) Cat. No.: HY-B1654A Cat. No.: HY-17429
Bioactivity: Flavin Adenine Dinucleotide Disodium is a redox cofactor, more Bioactivity: Flecainide(Tambocor) is a class 1C antiarrhythmic drug specifically a prosthetic group of a protein, involved in especially used for the management of supraventricular several important enzymatic reactions in metabolism. arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
Purity: 99.66% Purity: 99.65% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 25 mg 10 mg, 50 mg, 100 mg
Fluvastatin Fluvastatin sodium Cat. No.: HY-14664 Cat. No.: HY-14664A
Bioactivity: Fluvastatin (Leschol) inhibits HMG-CoA reductase activity with Bioactivity: Fluvastatin sodium is a competitive inhibitor of IC50 of 8 nM. hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease. Target: HMGCR Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg
Fondaparinux sodium Fosfructose (Fondaparin sodium; SR-90107A) Cat. No.: HY-B0597 (Diphosphofructose; Esafosfan; FDP) Cat. No.: HY-106950
Bioactivity: Fondaparinux sodium is an antithrombin-dependent factor Xa Bioactivity: Fosfructose is a cytoprotective natural sugar phosphate for inhibitor. the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma.
Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Size: 10mM x 1mL in Water, Size: 100 mg 5 mg, 10 mg, 25 mg, 50 mg
Fosinopril sodium FR 58664 (SQ28555) Cat. No.: HY-B0382 Cat. No.: HY-U00025
Bioactivity: Fosinopril Sodium is the ester prodrug of an Bioactivity: FR 58664 is a drug to treat heart failure disease. angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure. Target: ACE Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the… Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 20 mg 50 mg, 100 mg
FR183998 free base Fradafiban Cat. No.: HY-100302 (BIBU-52) Cat. No.: HY-101720
Bioactivity: FR183998 free base is a potent Na+/H+-exchange inhibitor, Bioactivity: Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH i complex with a K value of 148 nM. change in rat lymphocytes, rat and human platelets, d respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
32 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Fructose Fulacimstat Cat. No.: HY-N0395 (BAY1142524) Cat. No.: HY-109059
Bioactivity: Fructose is a simple ketonic monosaccharide found in many Bioactivity: Fulacimstat is an orally available chymase inhibitor, with plants, where it is often bonded to glucose to form the IC50s of 4, 3 nM for human and hamster chymase enzyme, disaccharide sucrose. respectively.
Purity: 98.0% Purity: >98% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 g, 5 g 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Gallamine Triethiodide Gap 26 Cat. No.: HY-B0416 Cat. No.: HY-P1082
Bioactivity: Gallamine Triethiodide is a synthetic nondepolarizing blocking Bioactivity: Gap 26 is a connexin mimetic peptide corresponding to the drug. residues 63-75 of connexin 43, which is a gap junction blocker.
Purity: 98.0% Purity: 99.30% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 1 mg, 5 mg, 10 mg
Gap 27 GBT 440 Cat. No.: HY-P0139 (Voxelotor) Cat. No.: HY-18681
Bioactivity: Gap 27, connexin43 mimetic peptide, is a gap junction Bioactivity: GBT 440 (Voxelotor) is an orally bioavailable modulator of inhibitor. Sequence: sickle cell hemoglobin. Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile.
Purity: 98.34% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
Gemfibrozil Ginsenoside Rd (CI-719) Cat. No.: HY-B0258 (Gypenoside VIII) Cat. No.: HY-N0043
Bioactivity: Gemfibrozil is an activator of PPAR-α, used as a Bioactivity: Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional
lipid-lowering drug; Gemfibrozil is also a nonselective activity with an IC50 of 12.05±0.82 μM in HepG2 cells. inhibitor of several P450 isoforms, with K values for i Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside… respectively. Purity: 99.91% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg
Ginsenoside Rg2 Ginsenoside Rg5 (Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2) Cat. No.: HY-N0602 Cat. No.: HY-N0908
Bioactivity: Ginsenoside Rg2 is one of the major active components of Bioactivity: Ginsenoside Rg5 is the main component of Red ginseng. ginseng. Ginsenoside Rg2 acts as a NF-κB inhibitor. Ginsenoside blocks binding of IGF-1 to its receptor with an
Ginsenoside Rg2 also reduces Aβ1-42 accumulation. IC50 of ~90 nM. Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65. Purity: 99.24% Purity: 99.36% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg
www.MedChemExpress.com 33
Ginsenoside Rk3 Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Cat. No.: HY-N0906 Chikusetsusaponin V; Ginsenoside-Ro) Cat. No.: HY-N0607
Bioactivity: Ginsenoside Rk3 is present in the roots Panax notoginseng herbs. Bioactivity: Ginsenoside Ro exhibits a Ca2+-antagonistic antiplatelet Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB effect with an IC 50 of 155 μM. Ginsenoside Ro reduces the transcriptional activity, with an IC50 of 14.24±1.30 μM in production of TXA2 more than it reduces the activities of HepG2 cells COX-1 and TXAS. Purity: >98% Purity: 98.69% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg
GKT137831 Gliclazide Cat. No.: HY-12298 (S1702; SE1702) Cat. No.: HY-B0753
Bioactivity: GKT137831 is a selective NADPH oxidase ( NOX1/4) inhibitor Bioactivity: Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. with Kis of 140 and 110 nM, respectively.
Purity: 99.43% Purity: 96.99% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 5 mg, 10 mg, 50 mg, 100 mg, 200 mg
Glycerol Glycerol derivative 1 (Glycerin) Cat. No.: HY-B1659 Cat. No.: HY-U00378
Bioactivity: Glycerol is a clear, colourless, viscous, sweet-tasting Bioactivity: Glycerol derivative 1 is a Glycerol derivative extracted from liquid. Glycerol is used in sample preparation and gel patent EP 672415 A1, compound (1). formation for polyacrylamide gel electrophoresis.
Purity: 99.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 100mL in Size: 1 mg, 5 mg, 10 mg
GlyH-101 GlyT2-IN-1 Cat. No.: HY-18336 Cat. No.: HY-18723
Bioactivity: GlyH-101 is a cell-permeable glycinyl hydrazone compound that Bioactivity: GlyT2-IN-1 is a glycine transporters GLYT2 inhibitor. blocks CFTR with Ki of 1.4 uM.
Purity: 99.35% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
GP2-114 GP531 Cat. No.: HY-U00191 Cat. No.: HY-U00116
Bioactivity: GP2-114 (GP-2-114) produces current-dependent cardiovascular Bioactivity: GP531 is a potent, second-generation adenosine regulating action when administered by transdermal iontophoresis. agent, is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
34 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
GPRP acetate GR148672X (Pefa 6003; Pefabloc FG) Cat. No.: HY-P0074A Cat. No.: HY-110390
Bioactivity: GPRP acetate is fibrinogen-related peptide, which inhibits the Bioactivity: GR148672X is a triacyglycerol hydrolase ( TGH) inhibitor with interaction of fibrinogen with the platelet membrane an IC50 of 4 nM extracted from patent WO 2001016358 A2. glycoprotein IIb/IIIa complex (GPIIb/IIIa). Sequence: Gly-Pro-Arg-Pro.
Purity: 98.0% Purity: 98.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 5 mg, 10 mg, 50 mg, 100 mg
GS967 GSK180736A Cat. No.: HY-12593 Cat. No.: HY-18990
Bioactivity: GS967 (GS-458967) is a potent, and selective inhibitor of Bioactivity: GSK180736A is a G protein-coupled receptor kinase 2 ( GRK2) cardiac late sodium current (late I ) with IC values of Na 50 inhibitor with an IC50 of 0.77 μM. 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
Purity: 99.96% Purity: 98.05% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
GSK2193874 GSK2256294A Cat. No.: HY-100720 (GSK 2256294) Cat. No.: HY-19644
Bioactivity: GSK2193874 is an orally active, potent, and selective TRPV4 Bioactivity: GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) antagonist with IC50 of 2 nM and 40 nM for rTRPV4 and hTRPV4. (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH. Purity: 98.91% Purity: 99.35% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
GSK269962A GSK484 (GSK 269962) Cat. No.: HY-15556 (GTPL8577; AOB6992) Cat. No.: HY-100514
Bioactivity: GSK269962A is a potent ROCK inhibitor with IC50s of 1.6 and 4 Bioactivity: GSK484 is a peptidylarginine deiminase 4 ( PAD4) inhibitor. GSK484 demonstrates high affinity binding to PAD4 with IC s nM for recombinant human ROCK1 and ROCK2 respectively. 50 of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.
Purity: 98.01% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Guanabenz Acetate Guanfacine hydrochloride (Wy8678 acetate) Cat. No.: HY-B0566 (Guanfacine) Cat. No.: HY-17416
Bioactivity: Guanabenz Acetate is an alpha-2 selective adrenergic agonist Bioactivity: Guanfacine Hcl, an anti-hypertensive agent, is a selective used as an antihypertensive agent. α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.
Purity: 98.88% Purity: 99.96% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 35
Guanoxabenz GW0742 (Hydroxyguanabenz) Cat. No.: HY-U00123 (GW610742) Cat. No.: HY-13928
Bioactivity: Guanoxabenz is an α2 adrenergic receptor agonist. Bioactivity: GW0742 is a high affinity PPAR β/δ agonist with an IC50 of 1
nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
Purity: >98% Purity: 99.63% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
GW3965 GW3965 hydrochloride Cat. No.: HY-10627 Cat. No.: HY-10627A
Bioactivity: GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ Bioactivity: GW3965 hydrochloride is a potent and selective LXR agonist
with EC50 of 190 and 30 nM, respectively. with EC50s of 190 and 30 nM for hLXRα and hLXRβ , respectively.
Purity: >98% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
GW4869 GW7647 Cat. No.: HY-19363 Cat. No.: HY-13861
Bioactivity: GW4869 is a noncompetitive neutral sphingomyelinase Bioactivity: GW7647 is a potent PPARα agonist, with EC50s of 6 nM, 1.1 inhibitor with an IC of 1 μM. 50 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively.
Purity: 96.35% Purity: 98.04% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Gypenoside XVII HCGRP-(8-37) (Gynosaponin S) Cat. No.: HY-N0553 (Human α-CGRP (8-37)) Cat. No.: HY-P1014
Bioactivity: Gypenoside XVII, a novel phytoestrogen belonging to the Bioactivity: HCGRP-(8-37) is a human calcitonin gene-related peptide gypenosides, can activate estrogen receptors. (hCGRP) fragment and also an antagonist of CGRP receptor. Sequence: Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly- Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Al a-Phe . Purity: 98.0% Purity: 98.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg
Hemin Hemorphin-7 (Hemin chloride) Cat. No.: HY-19424 Cat. No.: HY-P0318
Bioactivity: Hemin is an iron-containing porphyrin. Hemin is an Heme Bioactivity: Hemorphin-7 is a hemorphin peptide, an endogenous opioid oxygenase (HO)-1 inducer. peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE). Sequence:… Purity: 98.0% Purity: 99.65% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 1 g
36 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Hepronicate Heptaminol hydrochloride (Megrin) Cat. No.: HY-101701 (RP-2831 hydrochloride) Cat. No.: HY-B1231
Bioactivity: Hepronicate is a peripheral vasodilator with blood lipid Bioactivity: Heptaminol hydrochloride is a vasoconstrictor, used in the lowering action. treatment of low blood pressure, particularly orthostatic hypotension. in vivo: In the rat, Heptaminol hydrochloride prevents orthostatic hypotension, and increases the noradrenaline plasma concentration. In bovine chromaffin cells… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g
HOKU-81 HSF1A (4-Hydroxytulobuterol) Cat. No.: HY-50291 Cat. No.: HY-103000
Bioactivity: HOKU-81, a new bronchodilator, is one of the metabolites of Bioactivity: HSF1A is a cell-permeable activator of heat shock tulobuterol. transcription factor 1 ( HSF1).
Purity: 95.0% Purity: 99.33% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 25 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg
Hydralazine hydrochloride Hydrastinine hydrochloride Cat. No.: HY-B0464 Cat. No.: HY-B1181
Bioactivity: Hydralazine Hydrochloride is a direct-acting vasodilator that Bioactivity: Hydrastinine hydrochloride is a semisynthetic alkaloid from is used as an antihypertensive agent. the hydrolysis of the alkaloid Hydrastine, produced by oxidative splitting of Hydrastine hydrochloride with nitric acid in good yield, as a haemostatic drug.
Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10 mg, 50 mg, 100 mg 100 mg, 500 mg
Hydroxocobalamin hydrochloride Hydroxyfasudil (Vitamin B12a hydrochloride) Cat. No.: HY-B2209A (HA-1100) Cat. No.: HY-13911
Bioactivity: Hydroxocobalamin hydrochloride (Vitamin B12a hydrochloride) is Bioactivity: Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and a naturally occurring vitamin B12 form found in food and used 0.72 μM for ROCK1 and ROCK2, respectively. as a dietary supplement in the treatment of vitamin B12 deficiency.
Purity: 98.0% Purity: 98.13% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 5 mg, 10 mg, 50 mg
Hydroxyfasudil hydrochloride (HA-1100 hydrochloride; HA 1100 Hydroxyhexamide hydrochloride; HA1100 hydrochloride) Cat. No.: HY-13911A ((±)-Hydroxyhexamid) Cat. No.: HY-B1103
Bioactivity: Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s Bioactivity: Hydroxyhexamide is a pharmacologically active metabolite of of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Acetohexamide, used as a hypoglycemic agents.
Purity: 99.40% Purity: 99.68% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg
www.MedChemExpress.com 37
Ibutilide fumarate ICA (U70226E) Cat. No.: HY-B0387 (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) Cat. No.: HY-22044
Bioactivity: Ibutilide Fumarate is a Class III antiarrhythmic agent that is Bioactivity: ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a indicated for acute cardioconversion of atrial fibrillation SK channel inhibitor that has antileishmanial activity with an
and atrial flutter of a recent onset to sinus rhythm. IC50 of 2.1 µM.
Purity: 99.84% Purity: 99.63% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg
ICA-121431 Icariin Cat. No.: HY-16787 (Ieariline) Cat. No.: HY-N0014
Bioactivity: ICA-121431 is a nanomolar potent small molecule Nav1.7 channel Bioactivity: Icariin is a flavonol glycoside. Icariin inhibits PDE5 and inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition PDE4 activities with IC50s of 432 nM and 73.50 μM, on human, monkey and dog Nav1.7. respectively. Icariin also is a PPARα activator.
Purity: 98.29% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 100 mg, 200 mg, 500 mg
ICI 153110 ICI141292 Cat. No.: HY-100239 (Epanolol; Visacor) Cat. No.: HY-U00183
Bioactivity: ICI 153110 is an orally active phosphodiesterase inhibitor with Bioactivity: ICI141292 is a potent β-adrenoceptor partial agonist with a both vasodilating and inotropic properties which is designed greater affinity for β1- than β2-adrenoceptors. for the treatment of congestive cardiac failure.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg
Iganidipine Imidapril hydrochloride Cat. No.: HY-101685 (TA-6366) Cat. No.: HY-B1451
Bioactivity: Iganidipine is a Ca2+ antagonist. Bioactivity: Imidapril Hydrochloride is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg
Imidaprilate Imiglitazar (6366A; Imidaprilat) Cat. No.: HY-109592 (TAK-559) Cat. No.: HY-101649
Bioactivity: Imidaprilate is an active metabolite of TA-6366, acts as a Bioactivity: Imiglitazar (TAK559) is a potent and dual human PPARα and
potent angiotensin converting enzyme ( ACE) inhibitor, with PPARγ1 agonist with EC50 values of 67 and 31 nM. an IC50 of 2.6 nM, and is used in the research of hypertensive disease.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
38 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Implitapide Implitapide Racemate (AEGR 427) Cat. No.: HY-106130 Cat. No.: HY-U00329
Bioactivity: Implitapide is a microsomal triglyceride transfer protein ( Bioactivity: Implitapide Racemate is the racemate of Implitapide. MTP) inhibitor. Implitapide is a microsomal triglyceride transfer protein (MTP) inhibitor.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Indanazoline Indanidine Cat. No.: HY-U00075 Cat. No.: HY-101717
Bioactivity: Indanazoline (as monohydrochloride active substance of Farial) Bioactivity: Indanidine is an alpha-adrenergic agonist. is characterized by a pronounced vasoconstrictive action.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Indapamide Ingliforib Cat. No.: HY-B0259 (CP 368296; GPi 296) Cat. No.: HY-19396
Bioactivity: Indapamide is a non-thiazide sulphonamide diuretic compound, Bioactivity: Ingliforib is a glycogen phosphorylase inhibitor, with IC50s of generally used in the treatment of hypertension, as well as 52, 352 and 150 nM for liver, muscle and brain glycogen decompensated cardiac failure. phosphorylase, and has cardioprotective activity.
Purity: 99.61% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 g, 5 g
Inogatran Iopromide Cat. No.: HY-19660 Cat. No.: HY-B1362
Bioactivity: Inogatran is a synthetic thrombin inhibitor, developed for Bioactivity: Iopromide is a water-soluble, non-ionic, monomeric, the possible treatment and prophylaxis of arterial and venous low-osmolar, iodine-based contrast medium for intravascular thrombotic diseases. administration.
Purity: >98% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Irbesartan Isoprenaline hydrochloride (SR-47436; BMS-186295) Cat. No.: HY-B0202 (Isoproterenol hydrochloride) Cat. No.: HY-B0468
Bioactivity: Irbesartan is a highly potent and specific angiotensin II type Bioactivity: Isoprenaline hydrochloride is a non-selective beta-adrenergic 1 (AT1) receptor antagonist with IC50 of 1.3 nM. receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities.
Purity: 99.79% Purity: 99.0% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 200 mg, 1 g 10 mg, 50 mg, 100 mg, 200 mg, 500 mg
www.MedChemExpress.com 39
Isorhamnetin Isosorbide (3'-Methylquercetin) Cat. No.: HY-N0776 (D-Isosorbide; Dianhydro-D-glucitol) Cat. No.: HY-B1469
Bioactivity: Isorhamnetin is a flavonoid compound extracted from the Bioactivity: Isosorbide is used as a diuretic used mainly to treat Chinese herb Hippophae rhamnoides L.. Isorhamnetin hydrocephalus and is also used to treat glaucoma. suppresses skin cancer through direct inhibition of MEK1 and PI3K.
Purity: 98.00% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg 5 g
Isosorbide mononitrate Isosteviol (Isosorbide-5-mononitrate) Cat. No.: HY-B0642 ((-)-Isosteviol; iso-Steviol) Cat. No.: HY-N0872
Bioactivity: Isosorbide mononitrate(Isosorbide-5-mononitrate) is a Bioactivity: Isosteviol is a derivative of stevioside, a constituent of nitrate-class compound used for angina pectoris; acts by Stevia rebaudiana, which is commonly used as a noncaloric dilating the blood vessels so as to reduce the blood pressure. sugar substitute in Japan and Brazil.
Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 5 mg, 10 mg
Isradipine Istaroxime (PN 200-110) Cat. No.: HY-B0233 (PST2744) Cat. No.: HY-15718
Bioactivity: Isradipine(Dynacirc) is a calcium channel blocker with an IC50 Bioactivity: + + Istaroxime is a potent inhibitor of Na ,K -ATPase with IC50 of 34±8 μM. of 0.11 μM.
Purity: 99.24% Purity: >98% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Istaroxime hydrochloride ITD-1 (PST2744 (hydrochloride)) Cat. No.: HY-15718A Cat. No.: HY-12704
Bioactivity: Istaroxime hydrochloride is a potent inhibitor of Bioactivity: ITD-1 is the first selective TGFβ inhibitor with an IC50 of + + Na ,K -ATPase with IC50 of 0.11 μM. 460 nM.
Purity: 99.32% Purity: 98.66% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
IU1 Ivabradine hydrochloride Cat. No.: HY-13817 Cat. No.: HY-B0162A
Bioactivity: IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM. Bioactivity: Ivabradine (hydrochloride) is a new I f inhibitor with IC 50 of 2.9 μM, and used as a pure heart rate lowering agent.
Purity: 98.0% Purity: 98.39% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 10 mg, 50 mg, 100 mg, 200 mg
40 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
JI-101 K-604 dihydrochloride Cat. No.: HY-16265 Cat. No.: HY-100400A
Bioactivity: JI-101 is an orally available multi-kinase inhibitor of Bioactivity: K-604 dihydrochloride is a potent and selective VEGFR2 PDGFRβ and EphB4 with potent anti-cancer activity. acyl-CoA:cholesterol acyltransferase 1 ( ACAT-1) inhibitor
with an IC50 of 0.45±0.06 μM.
Purity: 99.78% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg
K134 KB3022 (OPC33509) Cat. No.: HY-U00186 (KBT3022; Pamicogrel) Cat. No.: HY-U00175
Bioactivity: K134 is a phosphodiesterase 3 ( PDE3) inhibitor. The IC50s of Bioactivity: KB3022 is a cyclooxygenase ( COX) inhibitor. K134 toward PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
KDR-in-4 KF 13218 Cat. No.: HY-101628 Cat. No.: HY-U00231
Bioactivity: KDR-in-4 is a potent kinase insert domain-containing receptor Bioactivity: KF 13218 is a potent, selective and long lasting
( KDR/VEGFR2) inhibitor with an IC50 of 7 nM. thromboxane B2 ( TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Kif15-IN-1 Kif15-IN-2 Cat. No.: HY-15948 Cat. No.: HY-15949
Bioactivity: Kif15-IN-1 is an inhibitor of the mitotic kinesin Kif15, and is Bioactivity: Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases. used for the research of cellular proliferative diseases.
Purity: 99.04% Purity: 96.51% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
Kisspeptin-10 Kisspeptin-10 Trifluoroacetate Cat. No.: HY-P0254 Cat. No.: HY-P0254A
Bioactivity: Kisspeptin-10 is a potent endogenous agonist for GPR54, used Bioactivity: Kisspeptin-10 Trifluoroacetate is the trifluoroacetate salt as a vasoconstrictor and an angiogenesis inhibitor. Sequence: form of Kisspeptin-10. Kisspeptin-10, the minimal kisspeptin Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2.
Purity: >98% Purity: 99.62% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg
www.MedChemExpress.com 41
Ko-3290 KP-457 Cat. No.: HY-101721 Cat. No.: HY-110397
Bioactivity: Ko-3290 is an antagonist of β-adrenoceptor, with Bioactivity: KP-457 is a selective a disintegrin and metalloproteinase 17 ( cardioselectivity and antilipolytic effects in animals. ADAM17) inhibitor, with higher selectivity for ADAM17 than
for other MMPs and ADAM10, and 50 50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), Purity: >98% Purity: and…>98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg
KRN4884 KU-32 Cat. No.: HY-U00201 Cat. No.: HY-108248
Bioactivity: KRN4884 is a K+ channel opener. In the presence of Bioactivity: KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death. intracellular ATP (1 mM), KRN4884 (0.1-3 μM) activates KATP
channels in a concentration-dependent manner ( EC50=0.55 μM). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg
L-(-)-α-Methyldopa L-(-)-α-Methyldopa hydrate (MK-351; Methyldopa) Cat. No.: HY-B0225 (MK-351 hydrate; Methyldopa hydrate) Cat. No.: HY-B0225B
Bioactivity: Methyldopa is an alpha-adrenergic agonist (selective for Bioactivity: L-(-)-α-Methyldopa hydrate is an alpha-adrenergic agonist α2-adrenergic receptors) psychoactive drug used as a (selective for α2-adrenergic receptors) psychoactive drug used sympatholytic or antihypertensive. Target: alpha-adrenergic as a sympatholytic or antihypertensive. Target: agonist Methyldopa is an alpha-adrenergic agonist (selective alpha-adrenergic agonist Methyldopa is an alpha-adrenergic for α2-adrenergic receptors) psychoactive drug used as a… agonist (selective for α2-adrenergic receptors) psychoactive… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 1 g Size: 10mM x 1mL in DMSO, 1 g
L-(-)-α-Methyldopa hydrochloride L-159282 (MK-351 hydrochloride; Methyldopa hydrochloride) Cat. No.: HY-B0225A (MK 996) Cat. No.: HY-19191
Bioactivity: L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic Bioactivity: L-159282 is a highly potent, orally active, nonpeptide agonist (selective for α2-adrenergic receptors) psychoactive angiotensin II receptor antagonist, with anti-hypertensive drug used as a sympatholytic or antihypertensive. Target: activity. alpha-adrenergic agonist Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive… Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 g Size: 1 mg, 5 mg, 10 mg, 20 mg
L-765314 L-Aspartic acid Cat. No.: HY-101385 Cat. No.: HY-N0666
Bioactivity: L-765314 is a potent and selective α1b adrenergic receptor Bioactivity: L-Aspartic acid is is an amino acid, shown to be a suitable
antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b prodrug for colon-specific drug deliverly. adrenergic receptor, respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 g
42 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
L-Glutathione reduced L-Homocysteine thiolactone hydrochloride (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) Cat. No.: HY-D0187 Cat. No.: HY-101404A
Bioactivity: L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) Bioactivity: L-Homocysteine thiolactone hydrochloride is an intramolecular is an endogenous antioxidant and is capable of scavenging thioester of homocysteine; prevents translational oxygen-derived free radicals. incorporation of homocysteine into proteins.
Purity: 99.64% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 g, 5 g Size: 10mM x 1mL in Water, 5 mg, 10 mg
L-Homocystine L-Kynurenine Cat. No.: HY-W011690 Cat. No.: HY-104026
Bioactivity: L-Homocystine is the oxidized member of the L-homocysteine. Bioactivity: L-Kynurenine is a metabolite of the amino acid L-tryptophan. Homocysteine is a pro-thrombotic factor, vasodilation L-Kynurenine is an aryl hydrocarbon receptor agonist. impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. Purity: 98.0% Purity: 99.40% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg
L-Lysine hydrochloride L-NMMA acetate Cat. No.: HY-N0470 (Tilarginine acetate; Methylarginine acetate) Cat. No.: HY-18732A
Bioactivity: L-lysine hydrochloride is an essential amino acid for humans Bioactivity: L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS with various benefits including treating herpes, increasing isoforms including NOS1, NOS2, and NOS3. The Ki values for calcium absorption, reducing diabetes-related illnesses and nNOS (rat), eNOS (human), and iNOS (mouse) are approximately improving gut health. 0.18, 0.4, and 6 µM, respectively.
Purity: 98.0% Purity: 98.0% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 g 10 mg, 25 mg, 50 mg, 100 mg
Labetalol hydrochloride Lacidipine (AH-5158 hydrochloride; Sch-15719W) Cat. No.: HY-B1108 Cat. No.: HY-B0347
Bioactivity: Labetalol hydrochloride is a mixed alpha/beta adrenergic Bioactivity: Lacidipine (Lacipil, Motens) is a L-type calcium channel antagonist that is used to treat high blood pressure. blocker.
Purity: 98.0% Purity: 99.78% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg, 100 mg, 200 mg
Lanatoside C Lappaconitine hydrobromide Cat. No.: HY-B1030 (Allapinine) Cat. No.: HY-N0118
Bioactivity: Lanatoside C is a cardiac glycoside, can be used in the Bioactivity: Lappaconitine hydrobromide, a diterpene alkaloid, is a drug treatment of congestive heart failure and cardiac for the treatment of cardiac arrhythmias. arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Target: in vitro: Dose-dependent reduction in dengue viral RNA and viral… Purity: 98.10% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg 10 mg, 50 mg
www.MedChemExpress.com 43
LAS-31180 LCZ696 Cat. No.: HY-101811 (Valsartan/sacubitril) Cat. No.: HY-18204A
Bioactivity: LAS-31180 is an inhibitor of phosphodiesterase 3, with Bioactivity: LCZ696 is a dual angiotensin II receptor and neprilysin positive inotropic and vasodilator properties. inhibitor.
Purity: >98% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
LDL-IN-3 Lemildipine Cat. No.: HY-U00054 (NB-818; NPK-1886) Cat. No.: HY-19663
Bioactivity: LDL-IN-3 is an anti-atherosclerotic compound extracted from Bioactivity: Lemildipine is a new dihydropyridine calcium entry blocker. patent WO/2005/039596A1, example C25 and patent US 6133467, example 3.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Lercanidipine Lercanidipine hydrochloride Cat. No.: HY-B0612 Cat. No.: HY-B0612A
Bioactivity: Lercanidipine is a calcium channel blocker of the Bioactivity: Lercanidipine hydrochloride is a calcium channel blocker of dihydropyridine class. the dihydropyridine class.
Purity: >98% Purity: 98.50% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg
Leucylarginylproline Levcromakalim Cat. No.: HY-P0143 ((-)-Cromakalim; BRL 38227) Cat. No.: HY-14255
Bioactivity: Leucylarginylproline is an angiotensin-converting enzyme ( Bioactivity: + LevCromakalim is an ATP-sensitive K channel (K ATP) ACE) inhibitor with an IC of 0.27μM. Sequence: Leu-Arg-Pro. 50 activator.
Purity: >98% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
Levosimendan Lidocaine (OR1259) Cat. No.: HY-14286 (Lignocaine) Cat. No.: HY-B0185
Bioactivity: Levosimendan(OR1259) is a calcium sensitiser used in the Bioactivity: Lidocaine, an amide local anesthetic, has anti-inflammatory management of acutely decompensated congestive heart failure. properties in vitro and in vivo, possibly due to an Target: Others Levosimendan is a calcium sensitiser used in attenuation of pro-inflammatory cytokines, intracellular the management of acutely decompensated congestive heart adhesion molecule-1 (ICAM-1), and reduction of neutrophils failure. Levosimendan is an inodilator indicated for the… influx. Purity: 98.0% Purity: 99.52% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 g, 10 g
44 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Lisinopril Lisinopril dihydrate Cat. No.: HY-18206 Cat. No.: HY-18206A
Bioactivity: Lisinopril is angiotensin-converting enzyme inhibitor, used in Bioactivity: Lisinopril Dihydrate is angiotensin-converting enzyme treatment of hypertension, congestive heart failure, and heart inhibitor, used in treatment of hypertension, congestive heart attacks. failure, and heart attacks. Target: ACE Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 5 g Size: 1 g, 5 g
Lixivaptan Lodelaben (VPA-985; WAY-VPA 985) Cat. No.: HY-14185 (SC-39026; Declaben) Cat. No.: HY-100240
Bioactivity: Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and Bioactivity: Lodelaben is a human neutrophil elastase inhibitor with an IC50 selective vasopressin receptor V2 antagonist, with IC50 values and Ki of 0.5 and 1.5 μM, respectively. of 1.2 and 2.3 nM for human and rat V2, respectively.
Purity: 99.57% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Lomitapide Lomitapide mesylate (AEGR-733; BMS-201038) Cat. No.: HY-14667 (AEGR-733 mesylate; BMS-201038 mesylate) Cat. No.: HY-14668
Bioactivity: Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of Bioactivity: Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein ( MTP) with an microsomal triglyceride-transfer protein (MTP) wtih in vitro
IC50 of 8 nM in vitro. IC50 of 8 nM.
Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg
Losartan Losartan potassium (DuP-753) Cat. No.: HY-17512 (DuP-753 potassium) Cat. No.: HY-17512A
Bioactivity: Losartan is an angiotensin II receptor antagonist, competing Bioactivity: Losartan (potassium) is an angiotensin II receptor type 1
with the binding of angiotensin II to AT1 receptors with IC50 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC of 20 nM. of 20 nM. 50
Purity: 99.24% Purity: 99.91% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g
Loureirin A Lovastatin Cat. No.: HY-N1505 (Mevinolin) Cat. No.: HY-N0504
Bioactivity: Loureirin A is a flavonoid extracted from Dragon's Blood, can Bioactivity: Lovastatin is a cell-permeable HMG-CoA reductase inhibitor inhibit Akt phosphorylation, and has antiplatelet activity. used to lower cholesterol.
Purity: 99.76% Purity: 99.47% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg 10 mg, 50 mg, 100 mg, 200 mg
www.MedChemExpress.com 45
LOXL2-IN-1 hydrochloride LP-533401 Cat. No.: HY-101771A Cat. No.: HY-15849
Bioactivity: LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with Bioactivity: LP-533401 is a Tryptophan hydroxylase 1 inhibitor that
an IC50 of 126 nM. regulates serotonin production in the gut.
Purity: 98.76% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 1 mg, 5 mg, 10 mg, 25 mg
LP-533401 hydrochloride LUF6000 Cat. No.: HY-15849A Cat. No.: HY-13236
Bioactivity: LP-533401 hydrochloride is a tryptophan hydroxylase 1 Bioactivity: LUF6000 is an allosteric modulator of the human A3 adenosine inhibitor that regulates serotonin production in the gut. receptor (AR).
Purity: >98% Purity: 99.34% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
LY285434 Lycopene Cat. No.: HY-U00202 Cat. No.: HY-N0287
Bioactivity: LY285434 is a suitable angiotensin II receptor antagonist. Bioactivity: Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.
Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 25 mg, 50 mg
Macitentan Macitentan n-butyl analogue (ACT-064992) Cat. No.: HY-14184 Cat. No.: HY-14184A
Bioactivity: Macitentan is an orally active, non-peptide endothelin Bioactivity: Macitentan n-butyl analogue is a n-butyl analogue of receptor antagonist for the treatment of idiopathic pulmonary Macitentan. Macitentan is an orally active, non-peptide dual fibrosis and pulmonary arterial hypertension. endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). Purity: 99.30% Purity: 97.90% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg
MAFP Magnolol (Methyl Arachidonyl Fluorophosphonate) Cat. No.: HY-103334 Cat. No.: HY-N0163
Bioactivity: MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, Bioactivity: Magnolol, a natural lignan isolated from the stem bark of active-site directed and irreversible inhibitor of cPLA2 and Magnolia officinalis, is a dual agonist of both RXRα and
iPLA2. MAFP is also a potent irreversible inhibitor of PPARγ, with EC50 values of 10.4 µM and 17.7 µM, anandamide amidase. respectively.
Purity: 98.0% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 27 mM * 500 uL in Methyl Acetate, Size: 10mM x 1mL in DMSO, 27 mM * 100 uL in Methyl Acetate, 10 mg, 50 mg, 100 mg
46 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Manidipine Manidipine dihydrochloride Cat. No.: HY-B0419 (CV-4093) Cat. No.: HY-17403
Bioactivity: Manidipine is a calcium channel blocker that is used Bioactivity: Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a clinically as an antihypertensive. calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.
Purity: >98% Purity: 99.18% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg
Mas7 Mavacamten (Mastoparan 7) Cat. No.: HY-P0258 (MYK461; SAR439152) Cat. No.: HY-109037
Bioactivity: Mas7, a structural analogue of mastoparan, is an activator of Bioactivity: Mavacamten is a modulator of cardiac myosin, with IC50s of heterotrimeric Gi proteins and its downstream effectors. 490, 711 nM for bovine cardiac and human cardiac, Sequence: respectively. Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH2.
Purity: >98% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg
McN5691 Megakaryocytes/platelets inducing agent (RWJ26240) Cat. No.: HY-U00218 Cat. No.: HY-112486
Bioactivity: McN5691 is a voltage-sensitive calcium channel blocker. Bioactivity: Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg
Meglutol Melanin Concentrating Hormone, salmon (Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid) Cat. No.: HY-B1189 (MCH (salmon)) Cat. No.: HY-P1525
Bioactivity: Meglutol is an antilipemic agent which lowers cholesterol, Bioactivity: Melanin Concentrating Hormone, salmon is a 19-amino-acid triglycerides, serum beta-lipoproteins and phospholipids, and neuropeptide initially identified in the pituitary gland of inhibits the activity of hydroxymethylglutarryl CoA teleost fish, which regulates food intake, energy balance, reductases, which is the rate limiting enzyme in the sleep state, and the cardiovascular system. biosynthesis of cholesterol. Melanin-concentrating hormone is a ligand for an orphan G… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 100 mg Size: 500u g, 1 mg, 5 mg
Methyl gallate Meticrane (Gallincin; NSC 363001) Cat. No.: HY-N2010 Cat. No.: HY-B0908
Bioactivity: Methyl gallate is a plant phenolic with antioxidant, Bioactivity: Meticrane is a diuretic. Meticrane inhibits the reabsorption anticancer, and anti-inflammatory activities. Methyl gallate of sodium and chloride ions in the distal convoluted tubule. also shows bacterial inhibition activity. Meticrane is used to treat essential hypertension.
Purity: 99.96% Purity: 98.79% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 100 mg
www.MedChemExpress.com 47
Metipranolol hydrochloride Metolazone Cat. No.: HY-16316 Cat. No.: HY-B0209
Bioactivity: Metipranolol is a non-selective β adrenergic receptor Bioactivity: Metolazone(Zaroxolyn) is primarily used to treat congestive blocking agent. heart failure and high blood pressure.
Purity: 99.94% Purity: 99.32% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 50 mg, 100 mg
Metoprolol Metoprolol Succinate Cat. No.: HY-17503 Cat. No.: HY-17503A
Bioactivity: Metoprolol (Toprol) is a selective β1 receptor blocker used in Bioactivity: Metoprolol Succinate (Toprol XL) is a selective β1 receptor treatment of several diseases of the cardiovascular system, blocker used in treatment of several diseases of the especially hypertension. IC50 value: Target: β1 receptor cardiovascular system, especially hypertension. IC50 value: Target: β1 receptor
Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg
Metoprolol Tartrate Mexiletine hydrochloride Cat. No.: HY-17503B Cat. No.: HY-A0093
Bioactivity: Metoprolol is a cardioselective β1-adrenergic blocking agent. Bioactivity: Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound.
Purity: >98% Purity: 99.96% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
MG 1 MGL-3196 Cat. No.: HY-U00110 (VIA-3196) Cat. No.: HY-12216
Bioactivity: MG 1 is an α1 adrenergic receptor antagonist. Bioactivity: MGL-3196 is a highly selective thyroid hormone receptor β (
THR-β) agonist with an EC50 value of 0.21 μM.
Purity: >98% Purity: 99.43% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Mibefradil Mibefradil dihydrochloride (Ro 40-5967) Cat. No.: HY-15553 (Ro 40-5967) Cat. No.: HY-15553A
Bioactivity: Mibefradil is a calcium channel blocker with moderate Bioactivity: Mibefradil dihydrochloride is a calcium channel blocker with 2+ 2+ selectivity for T-type Ca channels displaying IC50s of 2.7 moderate selectivity for T-type Ca channels displaying IC s of 2.7 μM and 18.6 μM for T-type and L-type currents, μM and 18.6 μM for T-type and L-type currents, respectively. 50 respectively. Purity: >98% Purity: 99.63% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
48 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Milrinone Minoxidil (Win 47203) Cat. No.: HY-14252 (U10858) Cat. No.: HY-B0112
Bioactivity: Milrinone is a PDE3 inhibitor, and also an inotrope and Bioactivity: Minoxidil(U 10858) is an antihypertensive vasodilator vasodilator. medication. Target: potassium channel Minoxidil, a potent antihypertensive agent, induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. The… Purity: 99.78% Purity: 99.84% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 1 g, 5 g
Mitochonic acid 5 MK-0354 (MA-5) Cat. No.: HY-111536 Cat. No.: HY-13008
Bioactivity: Mitochonic acid 5 binds mitochondria and ameliorates renal Bioactivity: MK-0354 is a partial agonist of GPR109a receptor, for tubular and cardiac myocyte damage. Mitochonic acid 5 hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no modulates mitochondrial ATP synthesis. activation of GPR109b.
Purity: 99.31% Purity: 98.03% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg
MK-7145 ML171 Cat. No.: HY-18277 (2-Acetylphenothiazine; 2-APT) Cat. No.: HY-12805
Bioactivity: MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. Bioactivity: ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective Nox1 inhibitor that blocks Nox1-dependent ROS generation,
with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.
Purity: >98% Purity: 99.50% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
ML277 ML365 (CID-53347902) Cat. No.: HY-12343 Cat. No.: HY-12345
Bioactivity: ML277(CID53347902) is a novel, potent and selective K(v)7.1 Bioactivity: ML365 is a novel selective small molecule inhibitor of (KCNQ1) potassium channel activator with EC50 of 270 nM. TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).
Purity: 98.14% Purity: 98.38% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
MM 07 Modecainide Cat. No.: HY-108003 (BMY 40327; MJ 14030) Cat. No.: HY-101723
Bioactivity: MM 07 is a biased apelin receptor agonist, with a KD of 300 Bioactivity: Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent. nM in CHO-K1 cells and a KD of 172 nM in human heart.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg
www.MedChemExpress.com 49
Moexipril hydrochloride Molidustat (RS-10085) Cat. No.: HY-B0378A (BAY 85-3934) Cat. No.: HY-12654
Bioactivity: Moexipril HCl is a potent orally active non-sulfhydryl Bioactivity: Molidustat (BAY 85-3934) is a novel inhibitor of angiotensin converting enzyme(ACE) inhibitor, which is used hypoxia-inducible factor prolyl hydroxylase ( HIF-PH) with mean
for the treatment of hypertension and congestive heart IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM failure. for PHD3.
Purity: 98.49% Purity: 98.33% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Molsidomine Moricizine (SIN-10; Morsydomine) Cat. No.: HY-B1069 (Moracizine) Cat. No.: HY-B0615
Bioactivity: Molsidomine is an orally active, long acting vasodilating Bioactivity: Moricizine is an antiarrhythmia agent used primarily for drug, metabolized in the liver to the active metabolite ventricular rhythm disturbances. linsidomine, which is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound. Purity: 99.74% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 500 mg
Moxisylyte hydrochloride MPC1304 (Thymoxamine hydrochloride) Cat. No.: HY-B1435 (Sapresta; Aranidipine) Cat. No.: HY-U00212
Bioactivity: Moxisylyte (hydrochloride) is (alpha 1-blocker) antagonistit Bioactivity: MPC1304 is a Ca2+ channel antagonist with potent and can vasodilates cerebral vessels without reducing blood long-lasting antihypertensive effects. pressure.
Purity: 99.66% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 1 g
MRE-269 MRS 2578 (ACT-333679) Cat. No.: HY-79593 Cat. No.: HY-13104
Bioactivity: MRE-269 is an active metabolite of selexipag, and acts as a Bioactivity: MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 selective IP receptor agonist. nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
Purity: 99.91% Purity: 95.67% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg 10 mg, 50 mg
Mulberrin N-Acetyl-Ser-Asp-Lys-Pro (Kuwanon C) Cat. No.: HY-N3513 Cat. No.: HY-P0266
Bioactivity: Mulberrin is a strong inhibitor of organic anion-transporting Bioactivity: N-Acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) for the N-terminal site of ACE. Sequence: Ac-Ser-Asp-Lys-Pro.
uptake with an IC50 value being 1.8±1.5 μM.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 1 mg, 5 mg, 10 mg, 25 mg
50 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
N-Acetylneuraminic acid N-Acetylprocainamide (NANA; Lactaminic acid) Cat. No.: HY-I0400 (Acecainide; NAPA) Cat. No.: HY-B1109
Bioactivity: N-Acetylneuraminic acid is a nine-carbon, sialic acid Bioactivity: N-Acetylprocainamide is a class III antiarrhythmic, which monosaccharide commonly found in glycoproteins on cell blocks K+ channels. membranes and in glycolipids such as gangliosides in mammalian cells. Studies suggest that N-Acetylneuraminic acid is useful biologically in neurotransmission, leukocyte extravasation,… Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg, 1 g 100 mg
N-Nornuciferine N6-(4-Hydroxybenzyl)adenosine Cat. No.: HY-N2129 (Para-topolin riboside) Cat. No.: HY-18775
Bioactivity: N-Nornuciferine is an aporphine alkaloid in lotus leaf that Bioactivity: N6-(4-Hydroxybenzyl)adenosine is a inhibitor of platelet
significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and aggregation induced in vitro by collagen and their activity 2.34 μM, respectively. range was demonstrated (IC50: 6.77-141 μM).
Purity: 99.18% Purity: 99.66% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 10 mg, 50 mg, 100 mg
Nafamostat Nafamostat hydrochloride Cat. No.: HY-B0190 Cat. No.: HY-B0190B
Bioactivity: Nafamostat is a broad spectrum serine protease inhibitor, Bioactivity: Nafamostat hydrochloride, a synthetic serine protease kallikrein inhibitor, and inhibits blood coagulation; is also inhibitor, is an anticoagulant. a possible complement inhibitor.
Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10 mg, 50 mg
Nafamostat mesylate Naftidrofuryl oxalate (FUT-175) Cat. No.: HY-B0190A (Nafronyl oxalate salt) Cat. No.: HY-B1107
Bioactivity: Nafamostat mesylate, a synthetic serine protease inhibitor, is Bioactivity: Naftidrofuryl is a drug used in the management of peripheral an anticoagulant. and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.
Purity: 95.85% Purity: 97.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 100 mg
Naftopidil Nagilactone B (KT-611; BM-15275) Cat. No.: HY-B0391 Cat. No.: HY-N3216
Bioactivity: Naftopidil (Flivas), a selective α1-adrenergic receptor Bioactivity: Nagilactone B, extracted from the root bark of Podocarpus nagi, antagonist or alpha blocker, is an antihypertensive drug. is a liver X receptor ( LXR) agonist.
Purity: 98.83% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 g, 10 g
www.MedChemExpress.com 51
Naminidil Nanofin (BMS 234303-01) Cat. No.: HY-100276 (2,6-Lupetidine) Cat. No.: HY-B1191
Bioactivity: Naminidil is a cyanoguanidine KATP opener. Bioactivity: Nanofin is neuropathic blocker, with antihypertensive effect, used for mild to moderate hypertension.
Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg
Naphazoline hydrochloride Napsagatran hydrate Cat. No.: HY-B0446 (Ro 46-6240 hydrate; Ro 46-6240/010 hydrate) Cat. No.: HY-15759A
Bioactivity: Naphazoline HCl is an ocular vasoconstrictor and imidazoline Bioactivity: Napsagatran hydrate is a novel and specific thrombin derivative sympathomimetic amine. inhibitor.
Purity: 96.55% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 1 g, 5 g, 10 g
Nateglinide NBTGR (A4166; Senaglinide) Cat. No.: HY-B0422 Cat. No.: HY-108322
Bioactivity: Nateglinide is an insulin secretagog agent used for the Bioactivity: NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of
treatment of non-insulin-dependent diabetes mellitus (NIDDM). nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM.
Purity: 98.11% Purity: 99.13% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg 10 mg, 50 mg
NCX899 Nebivolol Cat. No.: HY-101577 (R 065824) Cat. No.: HY-B0203
Bioactivity: NCX899 is a NO-releasing derivative of enalapril, and shows Bioactivity: Nebivolol selectively inhibits β1- adrenergic receptor with inhibitory activity against angiotensin-converting enzyme IC50 of 0.8 nM. (ACE) activity.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg
Nebivolol hydrochloride Nelociguat (R 065824 hydrochloride) Cat. No.: HY-B0203A (BAY60-4552) Cat. No.: HY-78237
Bioactivity: Nebivolol hydrochloride selectively inhibits β1- adrenergic Bioactivity: Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble receptor with IC50 of 0.8 nM. guanylate cyclase stimulator.
Purity: 98.0% Purity: 90.0% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
52 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
NEP-IN-2 Nepicastat Cat. No.: HY-U00336 (SYN117; RS-25560-197) Cat. No.: HY-13289
Bioactivity: NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the Bioactivity: Nepicastat (SYN117; RS-25560-197) is a dopamine research of proliferation in atherosclerosis, restenosis. beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg
Nepicastat hydrochloride Nexopamil racemate (SYN-117 hydrochloride; RS-25560-197 hydrochloride) Cat. No.: HY-13289A Cat. No.: HY-101727
Bioactivity: Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine Bioactivity: Nexopamil racemate is the racemate of Nexopamil. Nexopamil is beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 2+ a combined Ca / 5-HT2 antagonist on thrombus formation in 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 vivo and on platelet aggregation in vitro. nM(bovine/human dopamine beta-hydroxylase) Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of… Purity: 99.48% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg
Nicainoprol Nicorandil (RU-42924) Cat. No.: HY-100572 Cat. No.: HY-B0341
Bioactivity: Nicainoprol is a fast- sodium-channel blocking drug, which Bioactivity: Nicorandil is potassium channel activator. is a potent antiarrhythmic agent.
Purity: 99.48% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 50 mg
Nicotinic acid N-oxide Nicotinoyl cyclandelate Cat. No.: HY-B1061 (RV 12128) Cat. No.: HY-U00147
Bioactivity: Nicotinic acid N-oxide is used to treat hyperlipoidemia. Bioactivity: Nicotinoyl cyclandelate can be used to lower the perfusion pressure of cerebral blood vessels and the blood pressure of femoral artery.
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g
Nifedipine NIH-12848 Cat. No.: HY-B0284 Cat. No.: HY-101423
Bioactivity: Nifedipine is a potent calcium channel blocker and drug of Bioactivity: NIH-12848 is a putative phosphatidylinositol 5-phosphate
choice for cardiac insufficiencies. 4-kinase γ ( PI5P4Kγ) inhibitor with an IC50 of 1 μM.
Purity: 97.64% Purity: 99.41% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g, 10 g 5 mg, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 53
Nilvadipine Nimodipine (FK235; FR34235) Cat. No.: HY-14284 (BAY-e 9736) Cat. No.: HY-B0265
Bioactivity: Nilvadipine is a potent calcium channel antagonist, and the Bioactivity: Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with IC50 value is around 0.1 nM. antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy. Target: Calcium Channel Nimodipine is main use is in the prevention of cerebral… Purity: 98.0% Purity: 99.87% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 500 mg 100 mg, 500 mg
Nisoldipine Nitrendipine (BAY-k 5552) Cat. No.: HY-17402 (BAY-E-5009) Cat. No.: HY-B0424
Bioactivity: Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker Bioactivity: Nitrendipine is a calcium channel blocker with marked belonging to the dihydropyridines class, specific for L-type vasodilator action. Cav1.2 with IC50 of 10 nM.
Purity: 98.0% Purity: 99.29% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg, 1 g Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Nitroflurbiprofen Nitroprusside disodium dihydrate (Sodium nitroprusside (HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen) Cat. No.: HY-U00013 dihydrate; Sodium Nitroferricyanide(III) Dihydrate) Cat. No.: HY-A0119
Bioactivity: Nitroflurbiprofen is a cyclooxygenase ( COX) inhibitor with Bioactivity: Nitroprusside disodium dihydrate is a potent vasodilator nitric oxide (NO)-donating properties, modulates the increased working through releasing NO spontaneously in blood. Target: intrahepatic vascular tone in portal hypertensive cirrhotic Others Nitroprusside disodium dihydrate is a potent rats. vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks… Purity: 99.64% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 g
Nitroprusside Sodium NNC 55-0396 (Ro 21-2498) Cat. No.: HY-B0564 (NNC 55-0396 dihydrochloride) Cat. No.: HY-50722
Bioactivity: Sodium Nitroprusside is a potent vasodilator working through Bioactivity: NNC 55-0396, Mibefradil derivative, is a highly selective releasing NO spontaneously in blood. T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. IC50 value: 6.8 nM Target: Cav3.1 T-type channel NNC 55-0396 can be an essential… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg
Norepinephrine bitartrate monohydrate Norepinephrine hydrochloride (Noradrenaline bitartrate monohydrate) Cat. No.: HY-13715B (Noradrenaline hydrochloride) Cat. No.: HY-13715A
Bioactivity: Norepinephrine bitartrate monohydrate is a β1-selective Bioactivity: Norepinephrine hydrochloride is a β1-selective adrenergic
adrenergic receptor agonist with EC50 of 5.37 μM. receptor agonist with EC50 of 5.37 μM.
Purity: 99.75% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 500 mg, 1 g, 5 g 500 mg, 1 g, 5 g
54 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Norethindrone acetate Nortadalafil (19-Norethindrone acetate) Cat. No.: HY-B1710 (Demethyl Tadalafil) Cat. No.: HY-90009
Bioactivity: Norethindrone acetate is a female progestin approved by FDA Bioactivity: Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, for the treatment of endometriosis, uterine bleeding caused by currently marketed in pill form for treating erectile abnormal hormone levels, and secondary amenorrhea. dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
Purity: 99.33% Purity: 99.69% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 2 mg, 5 mg, 10 mg, 50 mg
Norverapamil hydrochloride NP118809 ((±)-Norverapamil hydrochloride; D591 hydrochlorid) Cat. No.: HY-100750 (39-1B4) Cat. No.: HY-14462
Bioactivity: Norverapamil is a calcium channel blocker it is the main Bioactivity: NP118809 is a potent N-type calcium channel blocker, with an active metabolite of verapamil. In vitro: Norverapamil is IC50 of 0.11 μM; also less potently inhibits L-type calcium similarly effective as verapamil at inhibiting isoniazid and channel with an IC of 12.2 μM. rifampicin tolerance and killing of intracellular M. 50 tuberculosis in the absence of other drugs. norverapamil, also… Purity: 99.46% Purity: 95.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg 100 mg, 200 mg, 500 mg
NQ301 NS-1619 Cat. No.: HY-101054 Cat. No.: HY-12496
Bioactivity: NQ301 is an antithrombotic agent; inhibits collagen-challenged Bioactivity: NS-1619 is a selective large conductance Ca2+-activated
rabbit platelet aggregation with an IC50 of 10 mg/mL. K+-channel activator.
Purity: 98.74% Purity: 99.30% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg
NS-304 NS309 (Selexipag; ACT-293987) Cat. No.: HY-14870 Cat. No.: HY-15416
Bioactivity: NS-304 is an orally available and potent agonist for the Bioactivity: NS309 is a positive modulator of small- and intermediate-
Prostacyclin ( PGI2) receptor (IP receptor). conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
Purity: 99.93% Purity: 98.76% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg
NSP-805 Nuvenzepine Cat. No.: HY-19102 Cat. No.: HY-U00119
Bioactivity: NSP-805 is a potent and selective inhibitor of guinea pig Bioactivity: Nuvenzepine is an mAChR antagonist previously in phase I cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent clinical trials for the treatment of gastrospasm. with vasodilator properties.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
www.MedChemExpress.com 55
Octreotide Oglufanide (SMS 201-995) Cat. No.: HY-P0036 (H-Glu-Trp-OH; L-Glutamyl-L-tryptophan) Cat. No.: HY-13718
Bioactivity: Octreotide is a somatostatin analog that binds to the Bioactivity: Oglufanide inhibits vascular endothelial growth factor (VEGF), somatostatin receptor, mainly subtypes 2, 3, and 5, which may inhibit angiogenesis. increases Gi activity, and reduces intracellular cAMP production. Sequence: Phe-Cys-Phe-Trp-Lys-Thr-Cys-Thr(Disulfide bridge: Cys2-Cys7). Purity: 99.15% Purity: 98.09% Clinical Data: Launched Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
Oleoylethanolamide (N-(2-Hydroxyethyl)oleamide; Olmesartan N-Oleoyl-2-aminoethanol; N-Oleoylethanolamide; …) Cat. No.: HY-107542 (RNH 6270; CS 088) Cat. No.: HY-17004
Bioactivity: Oleoylethanolamide is a high affinity endogenous PPAR-α Bioactivity: Olmesartan is an angiotensin II receptor (AT1R) antagonist agonist, which plays an important role in the treatment of used to treat high blood pressure. obesity and arteriosclerosis.
Purity: >98% Purity: 99.01% Clinical Data: Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
Olmesartan medoxomil Olprinone (CS 866) Cat. No.: HY-17005 (Loprinone) Cat. No.: HY-14254A
Bioactivity: Olmesartan medoxomil is a potent and selective angiotensin AT1 Bioactivity: Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. receptor inhibitor with IC50 of 66.2 μM.
Purity: 99.03% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg, 100 mg
Olprinone Hydrochloride OM-189 (Loprinone (Hydrochloride)) Cat. No.: HY-14254 Cat. No.: HY-100245
Bioactivity: Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase Bioactivity: OM-189 is a selective synthetic thrombin inhibitor. 3 (PDE3) inhibitor.
Purity: 99.77% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg
Omapatrilat Ombrabulin (BMS-186716) Cat. No.: HY-18208 (AVE8062) Cat. No.: HY-14797
Bioactivity: Omapatrilat is a dual inhibitor of the metalloproteases ACE Bioactivity: Ombrabulin is a derivative of CA-4 phosphate, which is known
and NEP with Ki values of 0.64 and 0.45 nM, respectively. to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
Purity: 97.22% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
56 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Ombrabulin hydrochloride Omecamtiv mecarbil (AVE8062; AVE8062A; AC7700) Cat. No.: HY-18256 (CK-1827452) Cat. No.: HY-14233
Bioactivity: Ombrabulin hydrochloride is a derivative of CA-4 phosphate, Bioactivity: Omecamtiv mecarbil is a selective myosin activator, used which is known to exhibit antivascular effects through for the treatment of cardiovascular diseases. selective disruption of the tubulin cytoskeleton of endothelial cells.
Purity: 99.57% Purity: 99.28% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
ONO-7300243 OPC-21268 Cat. No.: HY-100882 Cat. No.: HY-15009
Bioactivity: ONO-7300243 is a novel, potent lysophosphatidic acid receptor Bioactivity: OPC-21268 is an orally effective, nonpeptide, vasopressin V1 1 ( LPA1) antagonist with IC of 0.16 μM. 50 receptor antagonist with an IC50 of 0.4 μM.
Purity: 98.04% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
OPC-28326 Ornipressin Cat. No.: HY-101610 (POR-8) Cat. No.: HY-P0083
Bioactivity: OPC-28326 is a selective peripheral vasodilator and an Bioactivity: Ornipressin is a potent vasoconstrictor, hemostatic and renal
angatonist of α2-adrenergic receptor, with Ki of 2040, 285, agent. Sequence: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-{Orn}-Gly-NH2 and 55nM for α2A-, α2B- and α2C-adrenoceptors, respectively. (Disulfide bridge: Cys1-Cys6).
Purity: >98% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in Water, 2 mg, 5 mg, 10 mg, 50 mg
Osajin Otamixaban (CID 95168; NSC 21565) Cat. No.: HY-N3125 (FXV673) Cat. No.: HY-70035
Bioactivity: Osajin is the major bioactive isoflavone present in the fruit Bioactivity: Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid of Maclura pomifera with antitumor, antioxidant and acting, competitive and reversible fXa inhibitor that anti-inflammatory activities. effectively inhibits both free and prothrombinase-bound fXa.
Purity: >98% Purity: 97.78% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 100 mg
Ouabain Octahydrate Ozagrel (Acocantherine; G-Strophanthin) Cat. No.: HY-B0542 (OKY-046) Cat. No.: HY-B0428
Bioactivity: Ouabain Octahydrate is an inhibitor of Na+/K+-ATPase, used Bioactivity: Ozagrel(OKY-046) is an antiplatelet agent working as a for the treatment of congestive heart failure. thromboxane A2 synthesis inhibitor. Target: Thromboxane A2 Synthase Ozagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and rabbit… Purity: 99.79% Purity: 99.96% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 57
Ozagrel sodium PAF-AN-1 (OKY-046 sodium) Cat. No.: HY-B0428A Cat. No.: HY-U00040
Bioactivity: Ozagrel(OKY-046) sodium salt is an antiplatelet agent working Bioactivity: PAF-AN-1 is a platelet activating factor receptor ( PAF) as a thromboxane A2 synthesis inhibitor. Target: Thromboxane antagonist. A2 Synthase Ozagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and… Purity: 99.91% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg
Palmitic acid Palonosetron (Hexadecoic acid) Cat. No.: HY-N0830 Cat. No.: HY-A0018
Bioactivity: Palmitic acid is a long-chain saturated fatty acid commonly Bioactivity: Palonosetron is a 5-HT3 antagonist used in the prevention and found in both animals and plants. treatment of chemotherapy-induced nausea and vomiting (CINV).
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 100 mg 5 g
Palonosetron Hydrochloride Pamatolol Cat. No.: HY-A0021 Cat. No.: HY-U00019
Bioactivity: Palonosetron Hcl is a 5-HT3 antagonist used in the prevention Bioactivity: Pamatolol is a cardioselective beta-adrenoceptor antagonist and treatment of chemotherapy-induced nausea and vomiting without sympathomimetic activity. (CINV).
Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 50 mg, 100 mg, 200 mg
Pargyline hydrochloride PCA50941 Cat. No.: HY-A0091 Cat. No.: HY-U00034
Bioactivity: Pargyline hydrochloride is an irreversible inhibitor of Bioactivity: PCA50941 is a 1,4-dihydropyridine derivative, used for monoamine oxidase (MAO) that is used clinically to treat treatment for cardiovascular disease. moderate hypertension.
Purity: 99.91% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 500 mg
PD 123319 PD 123319 ditrifluoroacetate ((S)-(+)-PD 123319) Cat. No.: HY-10259 Cat. No.: HY-10259A
Bioactivity: PD 123319 (ditrifluoroacetate) is a potent, selective AT2 Bioactivity: PD 123319 (ditrifluoroacetate) is a potent, selective AT2
angiotensin II receptor antagonist with IC50 of 34 nM. angiotensin II receptor antagonist with IC50 of 34 nM.
Purity: >98% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg
58 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
PD 151746 PD-159020 Cat. No.: HY-19749 Cat. No.: HY-101598
Bioactivity: PD151746 is a calpain inhibitor, shows a 20-fold selectivity Bioactivity: PD-159020 is a non-selective ETA/ETB antagonist, with IC50s for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 of 30 and 50 nM for hETA and hETB, respectively. ± 0.77 μM). IC50 value: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1] Target: calpain in vitro: The μ-calpain inhibitor PD 151746 decreases… Purity: 98.21% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
PD0176078 Penbutolol sulfate Cat. No.: HY-U00236 ((-)-Terbuclomine) Cat. No.: HY-B1154
Bioactivity: PD0176078 is a newly found N-type Calcium channel blocker. Bioactivity: Penbutolol sulfate is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker. Penbutolol is a sympathomimetic drugused in the treatment of high blood pressure. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10 mg, 50 mg
Pentosan Polysulfate Pentoxifylline Cat. No.: HY-A0203 (PTX; Oxpentifylline) Cat. No.: HY-B0715
Bioactivity: Pentosan Polysulfate is a semi-synthetic drug used to treat Bioactivity: Pentoxifylline is a competitive nonselective phosphodiesterase various medical conditions including thrombi and interstitial inhibitor. Target: PDE Pentoxifylline is a competitive cystitis. nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate… Purity: 98.0% Purity: 99.91% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 1 g
Perhexiline maleate Perindopril Cat. No.: HY-B1334A (S-9490) Cat. No.: HY-B0130
Bioactivity: Perhexiline maleate is a potent carnitine palmitoyltransferase Bioactivity: Perindopril is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively. artery disease. Target: ACE Perindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of… Purity: 99.26% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 5 mg, 10 mg
Perindopril erbumine PF-06282999 (Perindopril tert-butylamine salt) Cat. No.: HY-B0130A Cat. No.: HY-19321
Bioactivity: Perindopril erbumine is a potent ACE inhibitor of which is Bioactivity: PF-06282999 is a potent and selective myeloperoxidase used to treat high blood pressure, heart failure or stable inhibitor which is potential useful for the treatment of coronary artery disease. Target: ACE Perindopril is a cardiovascular diseases. long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in… Purity: 99.90% Purity: 99.05% Clinical Data: Launched Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
www.MedChemExpress.com 59
PF-1355 Phenindione (PF-06281355) Cat. No.: HY-100873 (Rectadione) Cat. No.: HY-B0325
Bioactivity: PF-1355 is a selective 2-thiouracil mechanism-based MPO Bioactivity: Phenindione is an anticoagulant which functions as a Vitamin K inhibitor, used for treatment of vasculitic diseases. antagonist. Target: Others Phenindione(Rectadione) is an anticoagulant which functions as a Vitamin K antagonist. A lymphocyte transformation test showed proliferation of T-cells from the hypersensitive patient, but not from four controls on… Purity: 99.51% Purity: 98.44% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 50 mg
Phenoxybenzamine hydrochloride Phentolamine mesylate Cat. No.: HY-B0431A (Phentolamine methanesulfonate) Cat. No.: HY-B0362A
Bioactivity: Phenoxybenzamine hydrochloride is a selective antagonist of Bioactivity: Phentolamine mesylate is a competitive, reversible
both α-adrenoceptor and calmodulin that is commonly used α-adrenoceptor antagonist with an IC50 between 5 and 30 nM. for the treatment of hypertension, specifically caused by pheochromocytoma.
Purity: 98.0% Purity: 99.83% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 200 mg, 500 mg, 1 g 100 mg, 500 mg
Phosphoramidon Disodium Phosphorylcholine Cat. No.: HY-N2021A (Phosphocholine chloride) Cat. No.: HY-B2233
Bioactivity: Phosphoramidon disodium is a metalloprotease inhibitor. Bioactivity: Phosphorylcholine is an antigenic cell-surface component found Phosphoramidon inhibits endothelin-converting enzyme ( ECE), on many commensal and pathogenic bacteria that reside in the neutral endopeptidase ( NEP), and angiotensin-converting upper airway.
enzyme ( ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively. Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in Water, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 1 g
Piboserod Piboserod hydrochloride (SB-207266) Cat. No.: HY-15574 (SB-207266 hydrochloride) Cat. No.: HY-15574A
Bioactivity: Piboserod (SB 207266) is a selective 5-HT(4) receptor Bioactivity: Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist. antagonist.
Purity: 98.70% Purity: >98% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg
Piceatannol 3'-O-glucoside Pimobendan (Quzhaqigan) Cat. No.: HY-N2237 (pimobendane) Cat. No.: HY-B0204
Bioactivity: Piceatannol 3'-O-glucoside, an active component of Rhubarb, Bioactivity: Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 activates endothelial nitric oxide ( NO) synthase through μM.
inhibition of arginase activity with IC50s of 11.22 µM and 11.06 µM against arginase I and arginase II, respectively.
Purity: 99.0% Purity: 99.51% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
60 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Pimobendan hydrochloride Pirmenol hydrochloride (pimobendane hydrochloride) Cat. No.: HY-B0204A (Cl-845; (±)-Pirmenol hydrochlorid) Cat. No.: HY-100795A
Bioactivity: Pimobendan hydrochloride is a selective inhibitor of PDE3 with Bioactivity: Pirmenol hydrochloride inhibits IK.ACh by blocking IC50 of 0.32 μM. muscarinic receptors. The IC50 of Pirmenol for inhibition
of Carbachol-induced I K.ACh is 0.1 μM.
Purity: >98% Purity: 97.20% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg
Pitavastatin Pivalopril (NK-104) Cat. No.: HY-B0144A (Pivopril; RHC 3659(S)) Cat. No.: HY-U00041
Bioactivity: Pitavastatin (NK-104) is a potent HMG-CoA reductase inhibitor, Bioactivity: Pivalopril is a new orally active angiotensin converting Pitavastatin inhibited cholesterol synthesis from acetic acid enzyme ( ACE) inhibitor. with an IC50 of 5.8 nM in a human liver cancer cell line (HepG2).
Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
PKG drug G1 Polidocanol (Polyoxyethylene lauryl ether; Cat. No.: HY-112197 Polyoxyethyleneglycol Dodecyl Ether) Cat. No.: HY-B2106
Bioactivity: PKG drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to Bioactivity: Polidocanol is a sclerosing agent used successfully to treat vasodilation and blood pressure lowering by a C42 PKG extremity and esophageal varices and telangiectasias. Iα-independent mechanism.
Purity: 99.92% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 5 mg, 10 mg, 50 mg, 100 mg
Pparδ agonist 1 Prasugrel Cat. No.: HY-107901 Cat. No.: HY-15284
Bioactivity: Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 Bioactivity: Prasugrel is a platelet inhibitor with IC50 value of 1.8 μM. nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
Prasugrel hydrochloride Prasugrel Maleic acid Cat. No.: HY-15284A Cat. No.: HY-15284B
Bioactivity: Prasugrel hydrochloride is a platelet inhibitor with IC50 Bioactivity: Prasugrel Maleic acid is a platelet inhibitor with IC50 value value of 1.8 μM. of 1.8 μM.
Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 100 mg, 500 mg
www.MedChemExpress.com 61
Pratosartan Pravastatin (FW 7203; KD 3-671; KT 3671) Cat. No.: HY-101574 Cat. No.: HY-B0165
Bioactivity: Pratosartan is a selective angiotensin II receptor antagonist. Bioactivity: Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10 mg, 50 mg, 100 mg
Pravastatin sodium Prazosin Cat. No.: HY-B0165A Cat. No.: HY-B0193
Bioactivity: Pravastatin sodium is an HMG-CoA reductase inhibitor against Bioactivity: Prazosin is an alpha-adrenergic blocker and is a sympatholytic sterol synthesis with IC50 of 5.6 μM. drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.
Purity: 99.32% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg 10 mg, 50 mg, 100 mg, 200 mg
Prazosin hydrochloride Prifuroline Cat. No.: HY-B0193A Cat. No.: HY-100145
Bioactivity: Prazosin is an alpha-adrenergic blocker and is a sympatholytic Bioactivity: Prifuroline is an antiarrhythmic agent. drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic… Purity: 99.73% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 100 mg, 200 mg, 500 mg
Proanthocyanidins Procion Blue HB Cat. No.: HY-N0794 (Reactive Blue 2) Cat. No.: HY-D0965
Bioactivity: Proanthocyanidins are a class of polyphenols with Bioactivity: Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. antibacterial, antifungal and antiviral activities, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy.
Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg
Prodipine hydrochloride Progesterone Cat. No.: HY-101605 (Pregn-4-ene-3,20-dione) Cat. No.: HY-N0437
Bioactivity: Prodipine, a diphenyl-phosphonate derivative. The IC50s of Bioactivity: Progesterone is a steroid hormone that regulates the menstrual Prodipine for purified and plasma Dipeptidyl peptidase IV ( DPP cycle and is crucial for pregnancy. IV) from the rabbit are 4.5 μM and 30 μM, respectively.
Purity: >98% Purity: 98.79% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 1 g, 5 g
62 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Prolylleucine Pronethalol (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) Cat. No.: HY-112173 ((±)-Pronethalo) Cat. No.: HY-B1238
Bioactivity: Prolylleucine is a dipeptide containing branched-chain amino Bioactivity: Pronethalol is a non-selective beta-adrenergic blocking agent, acids. protect against and to reverse Digitalis-induced ventricular arrhythmias. Target: beta-adrenergic receptor
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 25 mg, 50 mg Size: 10 mg
Propafenone hydrochloride Prostaglandin E2 Cat. No.: HY-B0432A (Dinoprostone) Cat. No.: HY-101952
Bioactivity: Propafenone Hydrochloride is a class of anti-arrhythmic Bioactivity: Prostaglandin E2 is a hormone-like substance that participate medication, which treats illnesses associated with rapid heart in a wide range of body functions such as the contraction and beats such as atrial and ventricular arrhythmias. relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Purity: 99.70% Purity: 98.01% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Proxyphylline PRX-08066 Cat. No.: HY-B1742 Cat. No.: HY-15472
Bioactivity: Proxyphylline is a methylxanthine derivative clinical used as Bioactivity: PRX-08066 is a selective 5-hydroxytryptamine receptor 2B cardiac stimulant, vasodilator and bronchodilator. (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.
Purity: 99.46% Purity: 98.09% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 25 mg, 50 mg
PRX933 hydrochloride Pz-1 (GW876167 hydrochloride; BVT-933 hydrochloride) Cat. No.: HY-100171 Cat. No.: HY-U00437
Bioactivity: PRX933 hydrochloride is a 5-HT2c receptor agonist extracted Bioactivity: Pz-1 is a potent RET and VEGFR2 inhibitor with IC50s of less from patent WO 2014140631 A1. than 1 nM for both wild type kinases.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 5 mg, 10 mg, 25 mg
QF0301B Quinapril hydrochloride Cat. No.: HY-101690 Cat. No.: HY-B0477
Bioactivity: QF0301B is an α1 adrenergic receptor antagonist and a low α2 Bioactivity: Quinapril is a prodrug that belongs to the adrenoceptor, 5-HT2A, and histamine H1 receptor blocker. angiotensin-converting enzyme (ACE) inhibitor class of medications.
Purity: >98% Purity: 99.10% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
www.MedChemExpress.com 63
Quinidine Quinidine hydrochloride monohydrate Cat. No.: HY-B1751 Cat. No.: HY-B1302
Bioactivity: Quinidine is an antiarrhythmic agent for the treatment of Bioactivity: Quinidine hydrochloride monohydrate is a clinical abnormal heart rhythms and also malaria. anti-arrythmic drug which is also a potent blocker of K+
channel with an IC50 of 19.9 μM.
Purity: 98.0% Purity: 99.32% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg
R 80123 R-IMPP Cat. No.: HY-100615A Cat. No.: HY-101354
Bioactivity: R 80123 is the Z-isomer of R 79595, is also a highly selective Bioactivity: R-IMPP is an inhibitor of PCSK9 secretion. phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone). In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance… Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg
RAF265 Rafigrelide (CHIR-265) Cat. No.: HY-10248 (3,3-Dimethylanagrelide) Cat. No.: HY-U00383
Bioactivity: RAF265 (CHIR-265) is a potent selective inhibitor of Bioactivity: Rafigrelide is a platelet-lowering agent, and also has C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits antithrombotic properties. potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. IC50 value: 3-60 nM (B-Raf); 30 nM(EC50 for VEGFR2) [1] Target: B-Raf; VEGFR2; B-Raf V600E in vitro: RAF265 inhibits… Purity: 99.72% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg
Ralinepag Ramipril (APD811) Cat. No.: HY-16751 Cat. No.: HY-B0279
Bioactivity: Ralinepag is a potent, orally bioavailable and non-prostanoid Bioactivity: Ramipril is an angiotensin-converting enzyme (ACE) inhibitor
prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, with IC50 of 5 nM. 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
Purity: 98.87% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg
Ranolazine Ranolazine dihydrochloride (CVT 303; RS 43285-003) Cat. No.: HY-B0280 (RS 43285) Cat. No.: HY-17401
Bioactivity: Ranolazine is an antianginal medication. Bioactivity: Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). IC50 value: Target: sodium-dependent calcium… Purity: >98% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg, 1 g, 5 g
64 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Raspberry ketone Rat CGRP-(8-37) (Frambione; 4-(4-Hydroxyphenyl)-2-butanone) Cat. No.: HY-N1426 Cat. No.: HY-P0209
Bioactivity: Raspberry ketone is a major aromatic compound of red Bioactivity: Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a raspberry, widely used as a fragrance in cosmetics and as a highly selective CGRP receptor antagonist. Sequence: Val-Thr flavoring agent in foodstuff; also shows PPAR-α agonistic -His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-A activity. sp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2.
Purity: 99.91% Purity: 98.29% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 100 mg
Regadenoson Relacorilant (CVT-3146) Cat. No.: HY-A0168 (CORT 125134) Cat. No.: HY-109042
Bioactivity: Regadenoson is an A2A adenosine receptor agonist that is a Bioactivity: Relacorilant is a potent, selective and orally bioavailable
coronary vasodilator that is commonly used in pharmacologic glucocorticoid receptor antagonist, with a Ki of 7.2 nM in stress testing. HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-ba… Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg
Rentiapril racemate Revefenacin Cat. No.: HY-U00074 (TD-4208; GSK1160724) Cat. No.: HY-15851
Bioactivity: Rentiapril racemate is the racemate of Rentiapril. Rentiapril Bioactivity: Revefenacin (TD-4208; GSK1160724) is a potent mAChR is an angiotensin converting enzyme ( ACE) inhibitor. antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM
Purity: >98% Purity: 99.62% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Revizinone RF9 (R80122) Cat. No.: HY-100615 Cat. No.: HY-107382
Bioactivity: Revizinone is a novel selective phosphodiesterase (PDE) Bioactivity: RF9 is a potent and selective Neuropeptide FF receptor inhibitor with IC50 values on this enzyme to 0.036 microM. antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and target: phosphodiesterase (PDE)[3]; IC 50: 0.036 microM; [3] hNPFF2R, respectively. In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a… Purity: 98.10% Purity: 98.24% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg
RGH-5526 RGW2938 (GYKI-11679) Cat. No.: HY-100151 (Prinoxodan) Cat. No.: HY-U00208
Bioactivity: GYKI-11679 is a new antihypertensive agent. Bioactivity: RGW2938 is a phosphodiesterase inhibitor.
Purity: >98% Purity: 95.58% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
www.MedChemExpress.com 65
Rhodamine 123 Riociguat (R-22420; RH-123) Cat. No.: HY-D0816 (BAY 632521) Cat. No.: HY-14779
Bioactivity: Rhodamine 123 is a fluorescent dye (λ ex=503 nm, λ em=527 Bioactivity: Riociguat is an oral stimulator of soluble guanylate cyclase ( nm). sGC) used in the treatment of pulmonary hypertension.
Purity: 98.01% Purity: 99.58% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg
Rivaroxaban RK-24466 (BAY 59-7939) Cat. No.: HY-50903 (KIN 001-51) Cat. No.: HY-108318
Bioactivity: Rivaroxaban is a highly potent and selective, direct Factor Bioactivity: RK-24466 (KIN 001-51) is a potent and selective Lck
Xa ( FXa) inhibitor, achieving a strong gain in anti-FXa inhibitor; inhibits Lck (64-509) and LckCD isoforms with IC50s potency ( IC 0.7 nM; K 0.4 nM). 50 i of less than 1 and 2 nM, respectively.
Purity: 99.96% Purity: 89.21% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 1 mg, 5 mg
Ro 31-8220 Ro 31-8220 mesylate (Ro 31-8220 methanesulfonate; (Bisindolylmaleimide IX) Cat. No.: HY-13866A Bisindolylmaleimide IX mesylate) Cat. No.: HY-13866
Bioactivity: Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, Bioactivity: Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, rat brain PKC, respectively. Ro 31-8220 also significantly PKCε and rat brain PKC, respectively. Ro 31-8220 also
inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β ( IC50s, 3, 8, … significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3… Purity: >98% Purity: 99.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
Ro 46-2005 Ro-15-2041 Cat. No.: HY-19529 Cat. No.: HY-101807
Bioactivity: Ro 46-2005 is a novel synthetic non-peptide endothelin Bioactivity: Ro 15-2041 is a selective platelet phosphodiesterase inhibitor receptor antagonist, inhibits the specific binding of with antithrombotic properties. 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg
Ro-24-4736 ROCK-IN-1 Cat. No.: HY-19097 Cat. No.: HY-U00351
Bioactivity: Ro 24-4736 is a potent, selective, p.o.-active Bioactivity: ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 platelet-activating factor ( PAF) antagonist with a long nM for ROCK2. duration of action.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
66 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Ropitoin Rostafuroxin Cat. No.: HY-U00274 (PST 2238) Cat. No.: HY-12283
Bioactivity: Ropitoin (TR 2985) is a novel antiarrhythmic drug. Bioactivity: Rostafuroxin(PST 2238) is a antihypertensive compound; Na,K-ATPase antognist;displaced [3H]ouabain from the dogkidney Na+,K+-ATPase with IC50 of 1.5 nM.
Purity: >98% Purity: 96.70% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
RP 54275 RP-64477 (2-Octadecyl-1H-indole-5-carboxylic acid) Cat. No.: HY-100160 Cat. No.: HY-16437
Bioactivity: 2-Octadecyl-1H-indole-5-carboxylic acid is a novel Bioactivity: RP-64477 is a potent inhibitor of the cholesterol esterifying hypocholesterolaemic drug. enzyme Acyl-coenzyme A:cholesterol O-acyltransferase ( ACAT).
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg
RPR-260243 RWJ-445167 Cat. No.: HY-16915 Cat. No.: HY-19373
Bioactivity: RPR-260243 is a novel activator of HERG; modifies HERG Bioactivity: RWJ-445167 is a dual inhibitor of thrombin and factor Xa currents inhibited by dofetilide (IC50 = 58 nM); little effect with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent on HERG current amplitude and no significant effects on antithrombotic activity. steady-state activation parameters or on channel inactivation processes. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg, 10 mg
S0859 S107 Cat. No.: HY-15529 Cat. No.: HY-15292
Bioactivity: S0859, an N-cyanosulphonamide compound, reversibly inhibit Bioactivity: S107 is a RyR-selective 1,4-benzothiazepine derivative that NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition stabilizes RyR2 channels by enhancing the binding affinity of at approximately 30 microM). calstabin2 to mutant and/or PKA-phosphorylated channels.
Purity: 98.0% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg
S107 hydrochloride SA504 Cat. No.: HY-15292A (SA50Y; Sesden; Timepidium bromide) Cat. No.: HY-U00184
Bioactivity: S107 hydrochloride is a RyR-selective 1,4-benzothiazepine Bioactivity: SA504 is an anticholinergic agent. derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
Purity: 99.77% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 67
Salvianolic acid B Sapropterin dihydrochloride (6R-BH4 dihydrochloride; (Dan Shen Suan B; Lithospermic acid B) Cat. No.: HY-N1362 6R-Tetrahydro-L-biopterin dihydrochloride) Cat. No.: HY-A0124A
Bioactivity: Salvianolic acid B is an active ingredient of Salvia Bioactivity: Sapropterin dihydrochloride is a synthetic form of BH4 that is miltiorrhiza, which has been widely applied in China for the approved for the treatment of BH4 responsive PKU. management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication. IC50 value: Target: In vitro:… Purity: 99.88% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg
Sarpogrelate hydrochloride Saterinone hydrochloride (MCI-9042) Cat. No.: HY-10564 (BDF 8634 hydrochloride) Cat. No.: HY-101644A
Bioactivity: Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 Bioactivity: Saterinone hydrochloride is a phosphodiesterase III ( PDE III) antagonist, has been widely used as an anti-platelet agent for inhibitor. the treatment of PAD.
Purity: 98.39% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg
SBC-115076 SC-52012 Cat. No.: HY-12402 Cat. No.: HY-19163
Bioactivity: SBC-115076 is an anti-proprotein convertase subtilisin kexin Bioactivity: HY-19163 is an orally active fibrinogen receptor antagonist, type 9 (anti-PCSK9) compounds, for the treatment and/or with antiplatelet activities. prevention of cardiovascular diseases. Target: PCSK9 in vivo: SBC-115076 lowers cholesterol levels in mice that are fed high fat diet. Purity: 98.25% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg
SC40230 Sch-42495 racemate Cat. No.: HY-U00232 Cat. No.: HY-101682A
Bioactivity: SC40230 is a class I antiarrhythmic agent. Bioactivity: Sch-42495 racemate is the racemate of Sch-42495. Sch-42495 is a novel neutral metalloendopeptidase ( NEP) inhibitor. Sch-42495 is the orally active ethylester prodrug of SCH 42354.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
SCH00013 SEA0400 Cat. No.: HY-100718 Cat. No.: HY-15515
Bioactivity: SCH00013 is a cardiotonic agent that primarily acts via an Bioactivity: SEA0400 is a novel and selective inhibitor of the Na +-Ca 2+ increase in myofibrillar Ca++ sensitivity, have a significant exchanger ( NCX), inhibiting Na +-dependent Ca 2+ uptake in Ca(2+)sensitizing effect at pH 7.2 to 7.4. cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM. Purity: 98.0% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 2 mg, 5 mg, 10 mg, 50 mg
68 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Secoisolariciresinol diglucoside Semotiadil recemate fumarate (SDG) Cat. No.: HY-105008 Cat. No.: HY-U00026
Bioactivity: Secoisolariciresinol diglucoside is a plant lignan isolated Bioactivity: Semotiadil recemate fumarate is the recemate of Semotiadil from flaxseed, an antagonist of platelet activating fumarate. Semotiadil fumarate is a novel vasoselective Ca2+ factor-receptor, and used as an antioxidant. channel antagonist.
Purity: 99.95% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Senazodan Setipafant Cat. No.: HY-101693 (BN-50727; LAU-0901) Cat. No.: HY-101675
Bioactivity: Senazodan is a Ca 2+ sensitiser, and also shows inhibition Bioactivity: Setipafant is a platelet-activating factor ( PAF) antagonist. effect on PDE III.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Sfllrnpndkyepf Sildenafil Cat. No.: HY-P1000 (UK-92480) Cat. No.: HY-15025
Bioactivity: SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist Bioactivity: Sildenafil is a potent phosphodiesterase type 5 ( PDE5)
peptide. Sequence: inhibitor with IC50 of 5.22 nM. Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe.
Purity: 98.22% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg 50 mg, 100 mg, 200 mg
Sildenafil citrate Simvastatin (UK-92480 citrate) Cat. No.: HY-15025A (MK 733) Cat. No.: HY-17502
Bioactivity: Sildenafil citrate is a potent phosphodiesterase type 5 ( Bioactivity: Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA PDE5) inhibitor with IC of 5.22 nM. 50 reductase with a Ki of 0.2 nM.
Purity: 99.84% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg 50 mg, 100 mg, 200 mg, 500 mg
sitaxsentan Sitaxsentan sodium (IPI 1040; Sitax; Sitaxentan; TBC 11251) Cat. No.: HY-76520 (TBC11251 sodium salt; TBC11251) Cat. No.: HY-11103
Bioactivity: Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A Bioactivity: Sitaxsentan (sodium) is an orally active, highly selective (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is antagonist of endothelin A receptors. used in treatment of chronic heart failure.
Purity: >98% Purity: 98.73% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 69
SKA-121 SKLB1002 Cat. No.: HY-107414 Cat. No.: HY-13944
Bioactivity: SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits Bioactivity: SKLB1002 is a potent VEGFR2 inhibitor with an IC50 of 32 nM.
EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.
Purity: 98.64% Purity: 97.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
SL910102 SM 16 Cat. No.: HY-100292 Cat. No.: HY-111482
Bioactivity: SL910102 is a nonpeptide angiotensin AT1 receptor antagonist. Bioactivity: SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 250 mg, 500 mg
SM-6586 Small Cardioactive Peptide B SCPB Cat. No.: HY-19062 Cat. No.: HY-P1495
Bioactivity: SM-6586 is a calcium channel antagonist and inhibitor of Na Bioactivity: Small Cardioactive Peptide B (SCP B), a neurally active + 2+ +/H + and Na /Ca exchange transport, potentially for peptide, stimulates adenylate cyclase activity in particulate the treatment of cerebrovasular diseases and hypertension. fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg
SN 6 Sodium formononetin-3'-sulfonate Cat. No.: HY-107658 (Sul-F) Cat. No.: HY-13063
Bioactivity: SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, Bioactivity: Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. and inhibits 45Ca 2+ uptake by NCX1, NCX2, and NCX3, with
IC50s of 2.9, 16, and 8.6 μM, respectively.
Purity: 99.0% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 5 mg, 10 mg
Sodium ionophore III SOLENOPSIN (ETH2120) Cat. No.: HY-101109 Cat. No.: HY-16461
+ Bioactivity: Sodium ionophore III (ETH2120) is a Na ionophore suitable Bioactivity: Solenopsin is an ATP-competitive AKT inhibitor with IC50 for the assay of sodium activity in blood, plasma, serum. etc. value of 10 μM .
Purity: 98.07% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg, 200 mg
70 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Soluble epoxide hydrolase inhibitor Sotalol hydrochloride Cat. No.: HY-U00453 Cat. No.: HY-B0437
Bioactivity: Soluble epoxide hydrolase inhibitor is an inhibitor of soluble Bioactivity: Sotalol Hydrochloride is an adrenergic beta-antagonist that is epoxide hydrolase, and inhibits human soluble epoxide hydrolase used in the treatment of life-threatening arrhythmias.
(h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.
Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Sparsentan SQ-31765 (RE-021; BMS-346567; PS433540; DARA-a) Cat. No.: HY-17621 (SQ31765; SQ 31765) Cat. No.: HY-101740
Bioactivity: Sparsentan (RE-021; BMS-346567; PS433540; DARA-a) is a highly Bioactivity: SQ-31765 is a benzazepine calcium channel blocker. potent dual angiotensin II and endothelin A receptor antagonist
with Kis of 0.8 and 9.3 nM, respectively.
Purity: 99.08% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Squalamine lactate Squalene (Super Squalene; all-trans-Squalene; trans-Squalene; (MSI-1256F) Cat. No.: HY-16467 AddaVax; Nikko Squalane EX) Cat. No.: HY-N1214
Bioactivity: Squalamine lactate is an aminosterol compound discovered in Bioactivity: Squalene is an intermediate product in the synthesis of the tissues of the dogfish shark, with antimicrobial activity, cholesterol, and shows several pharmacological properties such and used for the treatment of neovascular age-related macular as hypolipidemic, hepatoprotective, cardioprotective, degeneration. antioxidant, and antitoxicant activity.
Purity: 95.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 50 mg
Stachydrine SU5408 Cat. No.: HY-N0298 (VEGFR2 Kinase Inhibitor I) Cat. No.: HY-103002
Bioactivity: Stachydrine is a major constituent of Chinese herb leonurus Bioactivity: SU5408 is a potent and cell-permeable inhibitor of VEGFR2 heterophyllus sweet used to promote blood circulation and kinase with an IC50 of 70 nM. dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 25 mg
Succinobucol Sulamserod (AGI-1067; Probucol monosuccinate) Cat. No.: HY-14937 (RS-100302) Cat. No.: HY-101668
Bioactivity: Succinobucol is a phenolic antioxidant with anti-inflammatory Bioactivity: Sulamserod is a 5-HT4 receptor antagonist, with and antiplatelet effects. antiarrhythmic activities.
Purity: 99.74% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
www.MedChemExpress.com 71
Sulfacarbamide Sulforaphane Cat. No.: HY-B1236 Cat. No.: HY-13755
Bioactivity: Sulfacarbamide is a blood sugar-lowering drug, also acting on Bioactivity: Sulforaphane is an isothiocyanate present naturally in widely the vegetative nervous system. consumed vegetables; has shown anticancer and cardioprotective activities.
Purity: 98.50% Purity: 98.90% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 25 mg, 50 mg, 100 mg
TA-01 TA-7552 Cat. No.: HY-100114 Cat. No.: HY-100253
Bioactivity: TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s Bioactivity: TA-7552 is a potent cholesterol-lowering agent. of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.
Purity: 96.34% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg
Tadalafil TAK-024 Cat. No.: HY-90009A Cat. No.: HY-100254
Bioactivity: Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. Bioactivity: TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.
Purity: 99.93% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg, 500 mg
Tanshinone I Tanshinone IIA (Tanshinone A) Cat. No.: HY-N0134 (Dan Shen ketone) Cat. No.: HY-N0135
Bioactivity: Tanshinone I is an inhibitor of type IIA human recombinant Bioactivity: Tanshinone IIA (Tan IIA) is one of the main fat-soluble
sPLA2 ( IC50=11 μM) and rabbit recombinant cPLA2 ( IC50=82 compositions in the root of red-rooted salvia. Tanshinone IIA μM). may suppress angiogenesis by targeting the protein kinase domains of VEGF/ VEGFR2.
Purity: 98.0% Purity: 99.07% Clinical Data: Phase 4 Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Tanshinone IIA sulfonate sodium (Sodium Tanshinone IIA TAS-301 sulfonate; Tanshinone IIA sodium sulfonate) Cat. No.: HY-N1370 Cat. No.: HY-18965
Bioactivity: Tanshinone IIA sulfonate (sodium) is a water-soluble Bioactivity: TAS-301 is an inhibitor of smooth muscle cell migration and derivative of tanshinone IIA, which acts as an inhibitor of proliferation, and inhibits PKC activation induced by PDGF. store-operated Ca 2+ entry (SOCE), and is used to treat cardiovascular disorders.
Purity: 98.0% Purity: 99.50% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
72 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Tasosartan Tecadenoson (WAY-ANA 756) Cat. No.: HY-A0250 (CVT-510) Cat. No.: HY-19661
Bioactivity: Tasosartan is a long-acting angiotensin II ( AngII) receptor Bioactivity: Tecadenoson (CVT-510) is a selective A1 adenosine receptor antagonist. agonist.
Purity: >98% Purity: 99.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Telmisartan Temocapril hydrochloride (BIBR 277) Cat. No.: HY-13955 Cat. No.: HY-B0384
Bioactivity: Telmisartan is a potent, long lasting antagonist of angiotensin Bioactivity: Temocapril Hydrochloride is a long-acting II type 1 receptor (AT1), selectively inhibiting the binding angiotensin-converting enzyme (ACE) inhibitor, used for the 125 treatment of hypertension. of I-AngII to AT1 receptors with IC50 of 9.2 nM.
Purity: 99.96% Purity: 99.52% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg, 1 g 10 mg, 50 mg
Tenapanor Tenatoprazole sodium (AZD1722; RDX5791) Cat. No.: HY-15991 (Tenatoprazole sodium salt) Cat. No.: HY-17421A
Bioactivity: Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with Bioactivity: Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H +/K +-ATPase with an IC IC50 values of 5 and 10 nM against human and Rat NHE3, 50 respectively. of 6.2 μM.
Purity: 98.80% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Terbogrel Terlipressin (BIBV 308SE) Cat. No.: HY-19189 Cat. No.: HY-12554
Bioactivity: Terbogrel is an orally available thromboxane A2 receptor Bioactivity: Terlipressin is a potent vasoconstrictor that acts via V1 antagonist and a thromboxane A2 synthase inhibitor, with receptors on arteriolar smooth muscle cells.
both IC50s of about 10 nM.
Purity: >98% Purity: 99.07% Clinical Data: Phase 2 Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
Tertatolol Tertiapin-Q ((±)-Tertatolol; Racemic Tertatolol; dl-Tertatolol) Cat. No.: HY-U00356 Cat. No.: HY-P1275
Bioactivity: Tertatolol is a potent antagonist of beta-adrenoceptor and Bioactivity: Tertiapin-Q is a highly selective blocker of GIRK1/4
5-HT receptor, with unique renal vasodilatatory effects. heterodimer and ROMK1 ( Kir1.1). Sequence: Ala-Leu-Cys-Asn- Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Ly s-Lys-NH2(Disulfide bridge: Cys3-Cys14, Cys5-Cys18).
Purity: >98% Purity: 97.46% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg
www.MedChemExpress.com 73
Terutroban Tetrahydrozoline hydrochloride (S-18886) Cat. No.: HY-16991 (Tetryzoline hydrochloride) Cat. No.: HY-B0556A
Bioactivity: Terutroban is a thromboxane/prostaglandin endoperoxide Bioactivity: Tetrahydrozoline (hydrochloride) is a α-adrenoceptor agonist. receptor antagonist.
Purity: 99.59% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 g, 5 g
Tezosentan TFLLR-NH2 Cat. No.: HY-17351 Cat. No.: HY-P0226
Bioactivity: Tezosentan is an endothelin (ET) receptor antagonist, with Bioactivity: TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 pA s of 9.5, 7.7 for ET and ET receptors, 2 A B μM. Sequence: Thr-Phe-Leu-Leu-Arg-NH2. respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg
TG100-115 Theodrenaline Cat. No.: HY-10111 ((±)-Theodrenaline) Cat. No.: HY-U00344
Bioactivity: TG100-115 is a selective PI3Kγ/ PI3Kδ inhibitor with IC50s of 83 Bioactivity: Theodrenaline is a cardiac stimulant, also acts as an and 235 nM, respectively. anti-hypotensive agent together with cafedrine.
Purity: 99.31% Purity: >98% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg
Thrombin inhibitor 1 Thrombin Receptor Activator for Peptide 5 TRAP-5 Cat. No.: HY-U00370 Cat. No.: HY-P1536
Bioactivity: Thrombin inhibitor 1 is a potent thrombin inhibitor ( Bioactivity: Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Ki=0.66 nM, 2xaPTT=0.43 μM). Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg
Thymosin beta 4 Tiapamil hydrochloride (Thymosin β4) Cat. No.: HY-P0029 (Ro 11-1781) Cat. No.: HY-101674
Bioactivity: Thymosin beta 4 is a potent regulator of actin polymerization Bioactivity: Tiapamil hydrochloride is a calcium channel blocker. in living cells. Sequence: Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile -Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-L ys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala -Gly-Glu-Ser. Purity: 98.19% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
74 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Ticagrelor Ticlopidine hydrochloride (AR-C 126532XX; AZD6140) Cat. No.: HY-10064 Cat. No.: HY-B0153A
Bioactivity: Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor Bioactivity: Ticlopidine hydrochloride is an adenosine diphosphate (ADP) antagonist for the treatment of platelet aggregation. receptor inhibitor against platelet aggregation with IC50 of ~2 μM. Target: Adenosine diphosphate (ADP) Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Ticlopidine hydrochloride inhibits platelet… Purity: 99.99% Purity: 99.99% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 g, 5 g
Timonacic Tirofiban (1,3-Thiazolidine-4-carboxylic acid) Cat. No.: HY-B1169 (L700462; MK383) Cat. No.: HY-17369B
Bioactivity: Timonacic is used as an adjuvant in the treatment of acute and Bioactivity: Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein hepatic disorders. It has also been used for the treatment of IIb/IIIa (integrins alphaIIbbetaIII) antagonist Target: some cases of cancer, through the induction of the reverse integrin IIb/IIIa Tirofiban hydrochloride monohydrate blocks transformation. platelet aggregation and thrombus formation. Tirofiban is an antithrombotic used in the treatment of unstable angina.… Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 100 mg
Tirofiban hydrochloride monohydrate TM5275 sodium Cat. No.: HY-17369 Cat. No.: HY-100447
Bioactivity: Tirofiban hydrochloride monohydrate is a potent non-peptide, Bioactivity: TM5275 sodium is a plasminogen activator inhibitor ( PAI-1) glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist with an IC50 of 6.95 μM. IC50 value: Target: integrin IIb/IIIa Tirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation. Tirofiban is an antithrombotic used in the… Purity: 99.99% Purity: 99.05% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
TN1 TNP-470 Cat. No.: HY-100826 (AGM-1470) Cat. No.: HY-101932
Bioactivity: TN1 is a potent fetal hemoglobin ( HbF) inducer. Bioactivity: TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 5 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg
Todralazine Tolvaptan (Ecarazine) Cat. No.: HY-B1001 (OPC-41061) Cat. No.: HY-17000
Bioactivity: Todralazine is capable of reducing blood pressure Bioactivity: Tolvaptan is a selective, competitive arginine vasopressin preferentially in hypertension. receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. IC50 value: 1.28 uM (inhibition of AVP-induced platelet aggregation) Target: vasopressin receptor 2 Tolvaptan (OPC-41061) is a… Purity: >98% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
www.MedChemExpress.com 75
TP-10 TP508 Cat. No.: HY-14550 Cat. No.: HY-P0316
Bioactivity: TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. Bioactivity: TP508 is a 23 amino acid synthetic peptide representing residues 508-530 of human prothrombin which is identified as a potential receptor-binding domain based on competition for high-affinity thrombin binding to fibroblasts. Sequence: Ala-G ly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp… Purity: 98.54% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 mg, 10 mg, 50 mg, 100 mg
TPO agonist 1 Trandolapril Cat. No.: HY-100380 (RU44570) Cat. No.: HY-B0592
Bioactivity: TPO agonist 1 can increase production of platelets by Bioactivity: Trandolapril(RU44570) is an ACE inhibitor used to treat high stimulating the TPO receptor in people with chronic ITP. blood pressure. Target: ACE Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions. Trandolapril acts by competitive inhibition of Angiotensin Converting Enzyme (ACE), a key… Purity: 98.0% Purity: 98.01% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Tranexamic acid Trapidil Cat. No.: HY-B0149 (AR-12008) Cat. No.: HY-B1016
Bioactivity: Tranexamic acid (Transamin) is an antifibrinolytic for Bioactivity: Trapidil is a vasodilator, is an antiplatelet drug with blocking lysine-binding sites of plasmin and elastase-derived specific platelet-derived growth factor. plasminogen fragments with IC50 of 5 mM. Target: Others Tranexamic acid is a synthetic derivative of the amino acid lysine. Tranexamic acid is frequently used in surgeries with… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in Water, 5 g, 10 g 10 mg, 50 mg
Trimetazidine dihydrochloride Trombodipine Cat. No.: HY-B0968 (PCA-4230) Cat. No.: HY-19052
Bioactivity: Trimetazidine dihydrochloride is a drug for angina pectoris. Bioactivity: Trombodipine is an antithrombotic agent. Trimetazidine is the first cytoprotective anti-ischemic agent , which improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg
Tropifexor Tropodifene (LJN452) Cat. No.: HY-107418 (Tropaphen) Cat. No.: HY-U00313
Bioactivity: Tropifexor is a novel and highly potent agonist of FXR with Bioactivity: Tropodifene (Tropaphen) is an α-Adrenergic receptor
an EC50 of 0.2 nM. inhibitor.
Purity: 99.33% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg
76 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
TS-011 Tulopafant Cat. No.: HY-15603 (RP 59227) Cat. No.: HY-101594
Bioactivity: TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic Bioactivity: Tulopafant is a platelet activating factor ( PAF) antagonist. acid synthesis.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
TY-52156 Tyrosine kinase-IN-1 Cat. No.: HY-19736 Cat. No.: HY-100315
Bioactivity: TY-52156 is a potent S1P3 receptor antagonist in a competitive Bioactivity: Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase
manner, and the Ki value is estimated to be 110 nM for S1P3 inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 receptor. and PDGFRα, respectively.
Purity: 99.68% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg
U89232 Ubrogepant Cat. No.: HY-U00173 (MK-1602) Cat. No.: HY-12366
Bioactivity: U-89232 appears to be a cardioselective KATP channel opener. Bioactivity: Ubrogepant (MK-1602) is a novel oral calcitonin gene-related peptide receptor ( CGRP) antagonist in development for acute treatment of migraine [1].
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg
UK51656 UNC2881 Cat. No.: HY-101707 Cat. No.: HY-15798
Bioactivity: UK51656 is a calcium antagonist with IC50 of 4 nM. Bioactivity: UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.
Purity: >98% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
Urapidil hydrochloride Uridine triphosphate Cat. No.: HY-B0354A (UTP; Uridine 5'-triphosphate) Cat. No.: HY-107372
Bioactivity: Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A Bioactivity: Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a receptor agonist. pyrimidine nucleoside triphosphate that participates in glycogen metabolism and synthesis of RNA during transcription.
Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 3 Size: 100 mg, 500 mg Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg
www.MedChemExpress.com 77
Urotensin I Urotensin II (114-124), human (Catostomus urotensin I) Cat. No.: HY-P1542 Cat. No.: HY-P1164
Bioactivity: Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF Bioactivity: Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF orphan receptor GPR14. 1, human CRF 2 and rat CRF 2α receptors in CHO cells, and
Kis of 0.4, 1.8, and 5.7 nM for hCRF 1, rCRF 2α and mCRF 2β Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg
Urotensin II, mouse Utibapril Cat. No.: HY-P1483 (FPL 63547) Cat. No.: HY-101681
Bioactivity: Urotensin II, mouse is an endogenous ligand for the orphan Bioactivity: Utibapril is an angiotensin-converting enzyme (ACE) inhibitor G-protein-coupled receptor GPR14 or SENR. with antihypertensive activities.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Vadadustat Valsartan (PG-1016548; AKB-6548) Cat. No.: HY-101277 (CGP 48933) Cat. No.: HY-18204
Bioactivity: Vadadustat is a novel, titratable, oral hypoxia-inducible Bioactivity: Valsartan (CGP-48933) is an angiotensin II receptor antagonist factor prolyl hydroxylase ( HIF-PH) inhibitor in development for treatment of high blood pressure and heart failure. for the treatment of anemia.
Purity: 98.02% Purity: 99.35% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg
Valsartan D9 Vardenafil hydrochloride (CGP-48933 D9) Cat. No.: HY-18204S Cat. No.: HY-B0442A
Bioactivity: Valsartan D9 (CGP-48933 D9) is deuterium labeled valsartan. Bioactivity: Vardenafil Hcl is a PDE5 inhibitor used for treating erectile Valsartan is an angiotensin II receptor antagonist for treatment dysfunction. of high blood pressure and heart failure.
Purity: >98% Purity: 98.62% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg
VAS2870 Vasonatrin Peptide VNP Cat. No.: HY-12804 Cat. No.: HY-P1556
Bioactivity: VAS2870 is a NADPH oxidase (NOX) inhibitor. Bioactivity: Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activity.
Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
78 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
Verapamil hydrochloride Vericiguat ((±)-Verapamil hydrochlorid) Cat. No.: HY-A0064 (BAY1021189) Cat. No.: HY-16774
Bioactivity: Verapamil hydrochloride is an L-type calcium channel Bioactivity: Vericiguat (BAY1021189) is a potent, orally available and antagonist. soluble guanylate cyclase stimulator.
Purity: 99.95% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Vernakalant Vernakalant Hydrochloride (RSD1235) Cat. No.: HY-14182 (RSD1235 hydrochloride) Cat. No.: HY-14183
Bioactivity: Vernakalant(RSD-1235) is an investigational mixed ion channel Bioactivity: Vernakalant hydrochloride is a mixed voltage- and blocker that can terminate acute atrial fibrillation (AF) in frequency-dependent Na+ and atria-preferred K+ channel humans at 2 to 5 mg/kg and may be more atrial-selective than blocker. IC50 for block by Vernakalant of wild-type and mutant available agents; in treatment of antiarrhythmic. Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0… Purity: >98% Purity: 99.33% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Vinburnine Vincamine ((-)-Eburnamonine; (-)-Vincamone) Cat. No.: HY-B1180 Cat. No.: HY-B1021
Bioactivity: Vincamone is a vinca alkaloid and a metabolite of vincamine, Bioactivity: Vincamine is a peripheral vasodilator, that increases blood is a vasodilator. flow to the brain.
Purity: >98% Purity: 99.93% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg
Vinpocetine Vitamin K (Ethyl apovincaminate) Cat. No.: HY-13295 Cat. No.: HY-B2172
Bioactivity: Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for Bioactivity: Vitamin K is a group of fat soluble vitamins, important for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels. the function of numerous proteins within the body, such as the IC50 value: Target: PDE1; Na+ channel coagulation factors, osteocalcin and matrix-Gla protein.
Purity: 99.43% Purity: 98.70% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 50 mg, 100 mg, 500 mg 50 mg, 100 mg, 200 mg, 500 mg
Vitamin K1 Vitamin K4 (Phylloquinone; Phytomenadione) Cat. No.: HY-N0684 (acetomenaphthone) Cat. No.: HY-B1508
Bioactivity: Vitamin K1 a fat-soluble, naturally occurring vitamin required Bioactivity: Vitamin K4 is a chemically synthesized Vitamin K which plays for blood coagulation and bone and vascular metabolism. an important role in the normal blood coagulation system.
Purity: 98.0% Purity: 99.80% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 200 mg, 1 g
www.MedChemExpress.com 79
Vorapaxar VTP-27999 (SCH 530348) Cat. No.: HY-10119 Cat. No.: HY-50768
Bioactivity: Vorapaxar is a protease-activated receptor (PAR-1) antagonist Bioactivity: VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is that inhibits thrombin-induced platelet activation. useful for Hypertension and End-Organ Diseases.
Purity: 99.91% Purity: >98% Clinical Data: Launched Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg
VTP-27999 2,2,2-trifluoroacetate VTP-27999 Hydrochloride (VTP-27999) Cat. No.: HY-50769 Cat. No.: HY-76652
Bioactivity: VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin Bioactivity: VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is inhibitor; VTP-27999 is useful for Hypertension and End-Organ useful for Hypertension and End-Organ Diseases. IC50 value: Diseases. Target: Renin
Purity: >98% Purity: 98.02% Clinical Data: Phase 1 Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg
Warfarin Win 58237 (WARF42; Athrombine-K) Cat. No.: HY-B0687 Cat. No.: HY-101661
Bioactivity: Warfarin(WARF42) is an anticoagulant drug normally used to Bioactivity: Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) prevent blood clot formation as well as migration. Target: inhibitor, with Ki of 170 nM for PDE V, possessing Others Warfarin is an anticoagulant normally used in the vasorelaxant activity. prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere… Purity: 99.45% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g, 5 g, 10 g
Win-62005 XEN445 Cat. No.: HY-U00136 Cat. No.: HY-12246
Bioactivity: Win-62005 is a cyclic AMP phosphodiesterase III ( PDE III) Bioactivity: XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively. vivo efficacy in raising plasma HDLc concentrations in mice.
Purity: >98% Purity: 96.42% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg
Xenopsin XL-784 Cat. No.: HY-P0253 Cat. No.: HY-19485
Bioactivity: Xenopsin: the neurotensin-like octapeptide from Xenopus skin at Bioactivity: XL-784 is a selective matrix metalloproteinases (MMP)
the carboxyl terminus of its precursor. Sequence: inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM {Glp}-Gly-Lys-Arg-Pro-Trp-Ile-Leu. for MMP-1MMP-2MMP-3MMP-8MMP-9MMP-13respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 250 mg, 500 mg
80 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]
XL041 Xylometazoline hydrochloride (BMS-852927) Cat. No.: HY-101973 Cat. No.: HY-B0475
Bioactivity: BMS-852927 is an LXRβ-selective agonist. Bioactivity: Xylometazoline Hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant.
Purity: 99.11% Purity: 99.88% Clinical Data: Phase 1 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 g
Y-9738 YM758 Cat. No.: HY-100258 Cat. No.: HY-U00309
Bioactivity: Y-9738 is a hypolipidemic agent. Bioactivity: YM758 is a “funny” I f current channel ( If channel) inhibitor.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
YS-201 YS-49 Cat. No.: HY-U00137 Cat. No.: HY-15477
Bioactivity: YS-201 is a dihydropyridine-type calcium channel antagonist Bioactivity: YS 49 inhibits Ang II-stimulated proliferation of VSMCs via previously in clinical trials for the treatment of angina induction of HO-1. pectoris and hypertension.
Purity: >98% Purity: 98.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg
YS-49 monohydrate Zatebradine Cat. No.: HY-15477A (UL-FS49) Cat. No.: HY-13422A
Bioactivity: YS 49 monohydrate inhibits Ang II-stimulated proliferation of Bioactivity: Zatebradine(UL-FS49) is a potent HCN channels antagonist, VSMCs via induction of HO-1. IC50 value: Target: HO-1 YS-49 is which decreased the heartbeat in a reversible manner; 92% a novel positive inotropic isoquinoline compound. YS-49 has inhibition of the hHCN1-mediated current at 10 uM. potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and… Purity: >98% Purity: 98.80% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg
Zatebradine hydrochloride ZD 7155(hydrochloride) (UL-FS-49; UL-FS-49CL) Cat. No.: HY-13422 Cat. No.: HY-102093
Bioactivity: Zatebradine(UL-FS49) Hcl is a potent HCN channels antagonist, Bioactivity: ZD 7155 hydrochloride is an angiotensin II receptor type 1 ( which decreased the heartbeat in a reversible manner; 92% AT1 receptor) antagonist. inhibition of the hHCN1-mediated current at 10 uM.
Purity: 99.15% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg
www.MedChemExpress.com 81
ZD-0892 ZD-1611 Cat. No.: HY-19254 Cat. No.: HY-19274
Bioactivity: ZD-0892 is a selective and potent inhibitor of a neutrophil Bioactivity: ZD-1611 is a potent, orally active, selective ETA receptor
elastase with Kis of 6.7 and 200 nM for human neutrophil antagonist, used for the research of ischemic stroke. elastase and porcine pancreatic elastase, respectively.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg
Zinc Pyrithione Zofenopril calcium Cat. No.: HY-B0572 (SQ26991) Cat. No.: HY-B0655
Bioactivity: Zinc Pyrithione is an antifungal and antibacterial agent Bioactivity: Zofenopril Calcium(SQ26991) is an antioxidant that acts as an disrupting membrane transport by blocking the proton pump. angiotensin-converting enzyme inhibitor. Target: Proton Pump Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and… Purity: 98.0% Purity: 97.91% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 5 mg, 10 mg, 50 mg, 100 mg
[Glu1]-Fibrinopeptide B [Pyr1]-Apelin-13 Cat. No.: HY-P0308 ([pGlu1]-Apelin-13) Cat. No.: HY-P1033
Bioactivity: [Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino Bioactivity: [Pyr1]-Apelin-13 is a highly potent, selective endogenous acid residues 1-14. Human fibrinopeptide B (hFpB), a apelin receptor (APJ) agonist. Sequence: thrombin-derived proteolytic cleavage product of the {Glp}-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe. fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts. Sequence:… Purity: >98% Purity: 98.23% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg
[Sar1, Ile8]-Angiotensin II β-CGRP, human (AngiotensinII; Angiotensin 2) Cat. No.: HY-P1564 (Human β-CGRP; CGRP-II (Human)) Cat. No.: HY-P1548
Bioactivity: [Sar1, Ile8]-Angiotensin II is a peptide that has multiple Bioactivity: β-CGRP, human is one of calcitonin peptides, acts via the effects on vascular smooth muscle, including contraction of complex of calcitonin-receptor-like receptor (CRLR) and
normal arteries and hypertrophy or hyperplasia of cultured receptor-activity-modifying protein (RAMP), with IC50s of 1 nM cells or diseased vessels. and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.
Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 500u g, 1 mg, 5 mg
82 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]