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Cardiovascular Disease

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Cardiovascular Disease Cardiovascular Disease Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk. www.MedChemExpress.com 1 Cardiovascular Disease Inhibitors & Modulators (+)-BAY-1251152 (-)-Blebbistatin Cat. No.: HY-103019 ((S)-(-)-Blebbistatin) Cat. No.: HY-13441 Bioactivity: (+)-BAY-1251152 is a CDK9 inhibitor extracted from patent WO Bioactivity: (-)-Blebbistatin is an S enantiomer of blebbistatin. 2014076091 A1, example 1. Blebbistatin is a potent and selective myosin II inhibitor with IC50s ranging from 0.5 to 5 μM. Purity: 99.73% Purity: 99.42% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg (-)-Sparteine sulfate pentahydrate ((-)-Sparteine sulfate (20S)-Protopanaxatriol salt; Lupinidine sulfate pentahydrate) Cat. No.: HY-B1304 (20(S)-APPT; g-PPT) Cat. No.: HY-N0835 Bioactivity: (-)-Sparteine sulfate pentahydrate is a class 1a Bioactivity: (20S)-Protopanaxatriol is a metabolite of ginsenoside, works antiarrhythmic agent and a sodium channel blocker. It is an through the glucocorticoid receptor (GR) and oestrogen alkaloid, can chelate the bivalents calcium and magnesium. receptor (ER), and is also a LXRα inhibitor. Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 5 mg, 10 mg, 50 mg, 100 mg (4-Acetamidocyclohexyl) nitrate (4E)-SUN9221 (BM121307) Cat. No.: HY-100295 Cat. No.: HY-U00367 Bioactivity: BM121307 is a guanylate cyclase activator that was in phase I Bioactivity: (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor development for the treatment of ischaemic heart disorders. and 5-HT2 receptor, with antihypertensive and anti-platelet The research has been discontinued. aggregation activities. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg (E)-Alprenoxime (R)-(-)-Phenylephrine hydrochloride (CDDD-1815) Cat. No.: HY-101804 (Phenylephrine hydrochloride) Cat. No.: HY-B0471 Bioactivity: (E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime Bioactivity: (R)-(-)-Phenylephrine hydrochloride is a selective is a site-activated ocular β-blocker. α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α 1D, α 1B and α 1A receptors respectively. Purity: >98% Purity: 98.10% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg (Z)2S,4R-Sacubitril (±)-Befunolol Cat. No.: HY-Z0075 Cat. No.: HY-101752 Bioactivity: (Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril Bioactivity: (±)-Befunolol is a β-adrenoceptor blocking agent. is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 1 mg, 5 mg 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] (±)-Equol (±)-WS75624B Cat. No.: HY-100583A Cat. No.: HY-100312 Bioactivity: (±)-Equol is the racemate of equol. Equol is a metabolite of Bioactivity: (±)-WS75624B is an endothelin converting enzyme ( ECE) the soy isoflavones, daidzin and daidzein. inhibitor with an IC50 of 0.03 μg/mL. Purity: 99.01% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 1-Linoleoyl Glycerol 11beta-Hydroxyprogesterone (1-Linoleoyl-rac-glycerol; 1-Monolinolein) Cat. No.: HY-111346 (11β-Hydroxyprogesterone) Cat. No.: HY-N2337 Bioactivity: 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has Bioactivity: 11beta-Hydroxyprogesterone is a potent inhibitors of been isolated from S. chinensis roots. 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. Purity: 99.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 10 mg, 50 mg 1400W Dihydrochloride 2R,4R-Sacubitril Cat. No.: HY-18731 Cat. No.: HY-78846 Bioactivity: 1400W dihydrochloride is a potent and selective inhibitor of Bioactivity: 2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is human inducible NO synthase with Ki values of 7 nM. approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. Purity: 99.66% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg 2R,4S-Sacubitril 2S,4R-Sacubitril Cat. No.: HY-78847 Cat. No.: HY-Z0081 Bioactivity: 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is Bioactivity: 2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with combination with valsartan for the treatment of patients with heart failure. heart failure. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 1 mg, 5 mg 2S,4S-Sacubitril 3-Amino-2-methylpropanoic acid Cat. No.: HY-78841 Cat. No.: HY-W012974 Bioactivity: 2S,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is Bioactivity: 3-Amino-2-methylpropanoic acid could induce browning of white approved by the Food and Drug Administration for use in fat and hepatic β-oxidation and is inversely correlated with combination with valsartan for the treatment of patients with cardiometabolic risk factors. heart failure. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 100 mg www.MedChemExpress.com 3 3-Methylsalicylic acid 4,6-Dioxoheptanoic acid (o-Cresotic acid; Hydroxytoluic acid) Cat. No.: HY-B1399 Cat. No.: HY-W010184 Bioactivity: 3-Methylsalicylic acid is a salicylic acid derivative compound Bioactivity: 4,6-Dioxoheptanoic acid is a potent inhibitor of heme with marked fibrinolytic activity in human plasma by biosynthesis. activating its fibrinolytic system. Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 10 mg, 50 mg, 100 mg 4-Methylumbelliferone 5-Amino-4-oxopentanoic acid (Hymecromone; 4-MU) Cat. No.: HY-N0187 Cat. No.: HY-W000450 Bioactivity: 4-Methylumbelliferone is a hyaluronic acid biosynthesis Bioactivity: 5-Amino-4-oxopentanoic acid is a non-protein amino acid that inhibitor with antitumoral and antimetastatic effects. plays a rate-limiting role in heme biosynthesis. Purity: 99.48% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg 5-HT2 antagonist 1 5-HT2A antagonist 1 Cat. No.: HY-U00365 Cat. No.: HY-U00286 Bioactivity: 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, Bioactivity: 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from with weak α1 adrenoceptor blocking activity. patent US5728835A and JP 1007727. 5-HT2A antagonist 1 may be useful in treatment of gastrointestinal disorders circulatory disorders. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg 5-HT3-In-1 5-Lipoxygenase-In-1 Cat. No.: HY-U00413 Cat. No.: HY-U00308 Bioactivity: 5-HT3-In-1 is extracted from patent EP0748807A1, compound Bioactivity: 5-Lipoxygenase-In-1 is a 5-Lipoxygenase inhibitor extracted example 8. It shows 5-HT3 inhibition activity. from patent EP 331232 A2, table 4, compound example 4.10. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg 5-R-Rivaroxaban A 779 (BAY 59-7939) Cat. No.: HY-76948 Cat. No.: HY-P0216 Bioactivity: 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban Bioactivity: A 779 is a specific antagonist of G-protein coupled receptor (BAY 59-7939) is a highly potent and selective, direct Factor (Mas receptor), which is an Ang1-7 receptor distinct from Xa ( FXa) inhibitor, achieving a strong gain in anti-FXa the classical AngII. Sequence: Asp-Arg-Val-Tyr-Ile-His-d-Ala. potency ( IC50 0.7 nM; Ki 0.4 nM). Purity: 99.72% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg 4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] A81988 Acebutolol hydrochloride (Abbott81988) Cat.
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