DOCSLIB.ORG

American Osteopathic College of Dermatology Journal of the American Osteopathic College of Dermatology

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
American Osteopathic College of Dermatology Journal of the American Osteopathic College of Dermatology Journal of the American Osteopathic College of Dermatology Journal of the American Osteopathic College of Dermatology 2009-2010 AOCD Officers President: Leslie Kramer, DO, FAOCD President-Elect: Bradley Glick, DO, FAOCD First Vice-President: James Towry, DO, FAOCD Second Vice-President: Karen Neubauer, DO, FAOCD Third Vice-President: David Grice, DO, FAOCD Secretary-Treasurer: Jere Mammino, DO, FAOCD Immediate Past President: Marc Epstein, DO, FAOCD Trustees: Celeste Angel, DO, FAOCD Alpesh Desai, DO, FAOCD Mark Kuriata, DO, FAOCD Editors Rick Lin, DO, FAOCD Jay S. Gottlieb, DO Andrew Racette, DO, FAOCD Jon Keeling, DO Suzanne Rozenberg, DO, FAOCD Editorial Review Board Kevin Belasco, DO Rich Bernert, M.D. Sponsors: Iqbal Bukhari, MD Global Pathology Laboratory JAOCD Ryan Carlson, DO Medicis Founding Sponsor Igor Chaplik, DO JAOCD Founding Sponsor Michael Conroy, M.D. Galderma Brad Glick, DO, FAOCD Ranbaxy Melinda Greenfield, DO Andrew J Hanly, MD David Horowitz, DO, FAOCD JAOCD Matt Leavitt, DO, FAOCD Founding Sponsor Mark Lebwohl, MD AOCD • 1501 E. Illinois • Kirksville, MO 63501 Rick Lin, DO 800-449-2623 • FAX: 660-627-2623 www.aocd.org Megan Machuzak, D.O. Jere Mammino, DO, FAOCD COPYRIGHT AND PERMISSION: written permission must be obtained from the Journal of the American Osteopathic College of Dermatology John Minni, DO for copying or reprinting text of more than half page, tables or figures. Navid Nami, DO Permissions are normally granted contingent upon similar permission from the author(s), inclusion of acknowledgement of the original source, Shaheen Oshtory, DO and a payment of $15 per page, table or figure of reproduced material. Permission fees are waived for authors wishing to reproduce their own John Perrotto, DO articles. Request for permission should be directed to JAOCD c/o AOCD Stephen Purcell, DO, FAOCD PO Box 7525 Kirksville, MO 63501 Copyright 2003 by the Journal of the American Osteopathic College of Michael Scott, DO, FAOCD Dermatology Kevin Spohr, DO Printed by: The Dimensional Group, Mason City, IA 50401 Proofreading: Julia Layton, Freelance Proofreading and Editing Journal of the American Osteopathic College of Dermatology VOLUME 19, NUMBER 1 FEBRUARY 2011 aocdJOURNAL OF THE CONTENTS Letter from the JAOCD Editors .....................................................................................................................................................................4 Irritant Contact Vasculitis with Systemic Symptoms After Exposure to the Agave Americana Plant .......................................................6 Joseph Del Priore, DO,* Helia Eragi, DO,** David C. Horowitz, DO, FACD*** Muir-Torre Syndrome: A Case Report ..........................................................................................................................................................8 Krina K. Chavda, DO,* Sanjosh Singh, DO, MPH,** Marvin Watsky, DO*** A Case Report: Adult-Onset Still’s Disease ................................................................................................................................................10 Garrett R. Bohrnstedt, D.O.,* Chad Johnston, D.O.,** Roxann Powers, M.D., F.A.A.D.,*** Rodney Kovach, MD**** Behçet’s Disease with MAGIC Syndrome in a Caucasian Female: A Case Report and Clinical Update .................................................12 Brooke Walls, DO,* Jamie Hale-Hollenbeck, MS-III,** Frank Armstrong, DO, FAOCD,*** Keith Kappeler, DO, FACOFP**** Bilateral Idiopathic Auricular Ossificans:A Case Report and Review of the Literature ...........................................................................17. Wade R. Keller, D.O.,* Ellecia Cook, D.O.,** Don A. Anderson, D.O., F.A.O.C.D., F.A.S.M.S. *** Keratitis-Ichthyosis-Deafness Syndrome ....................................................................................................................................................20 Amanda Beehler, DO,* Michelle Jeffries, DO,** Stephen Kessler, DO,*** Ronald Hansen, MD**** Lobular Capillary Hemangioma .................................................................................................................................................................22 Cynthia L. Chen, BA,* Scott Deckelbaum, DO,** Mark Horowitz, DO,*** David Horowitz, DO, FAOCD, FAAD**** Cutaneous Metastatic Breast Carcinoma: Case Report and Review of the Literature .............................................................................24 Jacqueline Thomas, DO,* Shawna Flanagan, MD,** Les Rosen, MD,*** Janet Allenby, DO**** Large Polypoid Dermatofibroma in a Young Boy: A Case Report.............................................................................................................29 Kurt Grelck, DO,* Janet Allenby, DO, FAOCD** Lichen Planus Pigmentosus-Inversus .........................................................................................................................................................32 Zaina Rashid, D.O.,* Michael Land, MSIV,** Sarah Shuker, MSI,*** Don Anderson, D.O., FAOCD, FASMS**** Multinucleate-cell Angiohistiocytoma: A Unique Case and Literature Review........................................................................................34 Julie Malchiodi, DO, FAOCD,* Jonathan D. Richey, DO, MHA,** Brian N. Parks, DO, PGY1,*** Cory D. Nelson, DO, PGY1,**** Annette LaCasse, DO, FAOCD***** A Case of Calciphylaxis and Review of the Literature ...............................................................................................................................38 Christine Brooks, MSIV,* Brandon Miner, DO,** Peter Saitta, DO,*** Steven Grekin, DO, FAOCD**** Multiple Juvenile Xanthogranuloma: An Uncommon Presentation of the Most Common Histiocytosis ............................................43 Andrea Baratta, DO,* Sourab Choudery, DO,** Suzanne Sirota Rozenberg, DO, FAOCD,*** Marvin S. Watsky, DO, FAOCD**** Use of Etanercept for patients with severe plaque psoriasis in the setting of advanced solid malignancies ...........................................46 Luis Dehesa, MD,* Magalys Vitiello, MD,** Francisco A. Kerdel, BSc, MBBS*** Papular-Purpuric Gloves and Socks Syndrome: A Case Report and Literature Review ..........................................................................48 Monica Nafsou, DO,* Patrick Keehan, DO** A Case of Kaposi’s Sarcoma .........................................................................................................................................................................43 Amara Sayed, D.O., FACOFP,* Janet Allenby, D.O., FAOCD** Ashy Dermatosis with Novel Homeopathic Treatment Using Enoxaparin: A Case Report and Literature Review ...............................47. Thomas Singer, D.O.,* Brad Glick, D.O.** Spitzoid Blue Nevus with Dysplasia: Case Study and Review ...................................................................................................................49 Robert A. Norman, DO, MPH, MBA,* Trupal Patel, B.S.** Central Centrifugal Cicatricial Alopecia: A Case Presentation and Literature Review ...........................................................................53 Joanna I. Sadowska, D.O., M.H.S.,* Robert A. Norman, D.O., M.P.H., M.B.A.** LETTER FROM THE EDITORS JAY GOTTLIEB, DO, FAOCD JON KEELING, DO, FAOCD Senior Editor CO-Editor Help the JAOCD to grow… The editors of the JAOCD want to take this opportunity to wish the entire AOCD a very happy and healthy New Year. We hope that your holiday season was exciting and spent with your family. The JAOCD continues to grow, and we are expanding our editorial board. The expanded board will ensure that we are able to review manuscripts in a timely and efficient way. The manuscripts continue to improve in both content and writing style. All residents are required by the EEC to have their annual papers reviewed, proofed and approved by their program directors. This has made the review process on our end much more efficient. Because of professional and personal obligations, Andrew Racette, D.O., has decided to step down as a co- editor of the JAOCD. We would like to thank Dr. Racette for his time and effort in helping the JAOCD grow. The JAOCD has hired our proofreader, Julia Layton, to become the copy editor of the journal. She will be in direct contact with the authors to make sure that their manuscripts are complete and in the proper format to be published in the JAOCD. We are very excited about having Julia step up into this new position. We are confident that this will serve to improve the quality of our journal and also make the journal more uniform and consistent in format and content. As always, we would like to increase the number of members that sit on our editorial board. Beginning with the next issue, all editorial-board members will have their photos in the front of the journal. We extend our thanks to all of the members of the AOCD who help to improve the quality of our journal. Special thanks are in order for Global Pathology, Galderma Pharmaceuticals, Medicis-The Dermatology Company and Ranbaxy Pharmaceuticals for their sponsorship of the JAOCD. The JAOCD would remain just an idea and a dream if we did not have their support. Sincerely, Jay Gottlieb, DO, FAOCD Senior Editor Jon Keeling, DO, FAOCD Co-Editor 4 LETTER FROM THE EDITORS NOTICE TO READERS The JAOCD staff is small and the budget is limited for the production of the JAOCD. The AOCD Education and Evaluating Committee (EEC) has made it a requirement, that every resident in the AOCD must submit their annual paper for consideration
Load more

Recommended publications
  • Expanding Phenotype of Hereditary Fibrosing Poikiloderma with Tendon
    CASE SERIES Expanding phenotype of hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis caused by FAM111B mutations: Report of an additional family raising the question of cancer predisposition and a short review of early-onset poikiloderma Rapha€elle Goussot, MD,a Megana Prasad, MD,b Corinne Stoetzel, MD,b Cedric Lenormand, MD, PhD,a Helene Dollfus, MD, PhD,b and Dan Lipsker, MD, PhDa Strasbourg, France Key words: FAM111B; inherited poikiloderma; pancreatic cancer. ereditary fibrosing poikiloderma with Abbreviations used: tendon contractures, myopathy, and pul- monary fibrosis (POIKTMP [MIM#615704]) IPMN: intraductal papillary mucinous H neoplasm is an extremely rare syndromic form of autosomal POIKTMP: hereditary fibrosing poikiloderma dominant poikiloderma. This genetic disorder was with tendon contractures, myopathy, first identified in a South African family in 2006.1 To and pulmonary fibrosis date, 3 families and 9 independent sporadic cases RTS: Rothmund-Thomson syndrome have been reported.2-4 Here we report an additional family of POIKTMP and expand the clinical spec- trum. We describe, for the first time to our knowl- early childhood. Clinical evaluation found a very edge, a pancreatic cancer in the clinical course in 1 severe case of poikiloderma, predominant in the patient. We also address the differential diagnosis of sun-exposed areas, resulting from the combination inherited poikiloderma and related disorders. of skin atrophy, mottled pigmentation with hyper- pigmented and hypopigmented lesions, and telan- CASE SERIES giectasia (Fig 1, A). He had a distinct intolerance for In 2007, at the Strasbourg University Hospital, the heat with marked hypohidrosis. Diffuse xerosis was department of medical genetics referred a family to combined with multiple depigmented macules on the dermatology department with a diverse clinical the trunk and limbs.
    [Show full text]
  • Immunohistochemical Analysis of S100-Positive Epidermal
    An Bras Dermatol. 2020;95(5):627---630 Anais Brasileiros de Dermatologia www.anaisdedermatologia.org.br DERMATOPATHOLOGY Immunohistochemical analysis of S100-positive ଝ,ଝଝ epidermal Langerhans cells in dermatofibroma Mahmoud Rezk Abdelwhaed Hussein Department of Pathology, Assuit University Hospital, Assuit, Egypt Received 3 February 2020; accepted 12 April 2020 Available online 12 July 2020 Abstract Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the KEYWORDS immunocompetent cells of the epidermis, and they represent the first defense barrier of the Histiocytoma, benign immune system towards the environment. The objective was to immunohistologically compare fibrous; the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against Skin neoplasms; those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 S100 Proteins molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epidermis overlying the tumor (1.44 ± 0.33, p < 0.05). The quantitative deficit of Langerhans cells in the epidermis overlying dermatofibroma may be a possible factor in its development. © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana,˜ S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Langerhans cells (LCs) are the exclusive antigen-presenting tions stained with hematoxylin and eosin as ‘‘clear cells’’ cells of the normal human epidermis.
    [Show full text]
  • Storiform Collagenoma: Case Report Colagenoma Estoriforme: Relato De Caso
    CASE REPORT Storiform collagenoma: case report Colagenoma estoriforme: relato de caso Guilherme Flosi Stocchero1 ABSTRACT INTRODUCTION Storiform collagenoma is a rare tumor, which originates from the Storiform collagenoma or sclerotic fibroma is a rare proliferation of fibroblasts that show increased production of type-I benign skin tumor that usually affects young adults collagen. It is usually found in the face, neck and extremities, but and middle-age individuals of both sexes. This tumor is it can also appear in the trunk, scalp and, less frequently, in the slightly predominant in women. Storiform collagenoma oral mucosa and the nail bed. It affects both sexes, with a slight female predominance. It may be solitary or multiple, the latter being appears as a small papule or solid fibrous nodule. an important marker for Cowden syndrome. It presents as a painless, It is well-circumscribed, pink, whitish or skin color, solid nodular tumor that is slow-growing. It must be considered in the painless and of slow-growing. This tumor is often differential diagnosis of other well-circumscribed skin lesions, such as found in face and limbs, but it can also appears in dermatofibroma, pleomorphic fibroma, sclerotic lipoma, fibrolipoma, the chest, scalp and, rarely, in oral mucosa and nail giant cell collagenoma, benign fibrous histiocytoma, intradermal Spitz bed. Storiform collagenoma often appears as single nevus and giant cell angiohistiocytoma. tumor, and the occurrence of multiple tumors is an important indication of Cowden syndrome, which is Keywords: Collagen; Hamartoma; Skin neoplasms; Fibroma; Skin; Case a heritage genodermatosis of autosomal dominant reports condition.(1-4) Storiform collagenoma has as differential diagnosis other well-circumscribed skin tumors such RESUMO as dermatofibroma, pleomorphic fibroma, sclerotic O colagenoma estoriforme é um tumor raro originado a partir da lipoma, fibrolipoma, giant cell collagenoma, benign proliferação de fibroblastos com produção aumentada de colágeno tipo I.
    [Show full text]
  • Pattern of Skin Diseases at University of Benin Teaching Hospital, Benin City, Edo State, South-South Nigeria: a 12 Month Prospective Study
    www.ccsenet.org/gjhs Global Journal of Health Science Vol. 4, No. 3; 2012 Pattern of Skin Diseases at University of Benin Teaching Hospital, Benin City, Edo State, South-South Nigeria: A 12 Month Prospective Study B. A. Ukonu1 & E. U. Eze2 1 University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria 2 University of Benin Teaching Hospital, Benin City, Edo State, Nigeria Correspondence: Ukonu, Agwu Bob (MBBS, FMCP), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. Tel: 234-805-791-5902, 234-702-675-1965. E-mail: [email protected] Received: January 4, 2012 Accepted: January 15, 2012 Online Published: May 1, 2012 doi:10.5539/gjhs.v4n3p148 URL: http://dx.doi.org/10.5539/gjhs.v4n3p148 Abstract Background and Objective: This study aims to look at the pattern and incidence of skin diseases seen in Dermatology/Venereology clinic at the University of Benin Teaching Hospital, Benin City, Edo State, South-South Zone, Nigeria and compare it with other zones of Nigeria. Materials and Methods: This was a prospective study on pattern and incidence of skin diseases in new patients presenting at the Dermatology/ Venereology outpatient clinic of the University of Benin Teaching Hospital, Benin City, Edo State, South-South, Nigeria, from September 2006 to August 2007. All patients were seen by the researchers. Diagnosis were made clinically and sometimes with the support of histopathology. Results: A total number of 4786 patients were seen during the study period and these comprised 2647 HIV/AIDS patients and 2112 pure Dermatological patients. Out of 4786 patients, 755 (15.8%) were new patients.
    [Show full text]
  • The Effectiveness of Topical Scar-Reducing Therapies Administered for Scarring Due to Burns and Other Causes: a Retrospective Pilot Clinical Research
    ORIGINAL ARTICLE Aksoy et al. / Gulhane Med J 2018;60: 139-144 139 The effectiveness of topical scar-reducing therapies administered for scarring due to burns and other causes: A retrospective pilot clinical research Hasan Mete Aksoy,1 Berna Aksoy,2 Aslı Tatlıparmak,2 Emel Çalıkoğlu3 (1) Bahçeşehir University, School of Medicine, Plastic and Reconstructive Surgery, Istanbul, Turkey (2) Bahçeşehir University, School of Medicine, Dermatology, Istanbul, Turkey (3) Aksaray University, Faculty of Medicine, Dermatology, Aksaray, Turkey Date submitted: ABSTRACT Oct 019, 2017 Aims: Multiple modalities are used to treat scarring; however, data on the efficacy of Date accepted: Aug 25, 2018 the topical scar-reducing treatments most frequently used by patients is insufficient. Online publication date: This study aimed to retrospectively determine the effectiveness of topical scar-reducing December 15, 2018 treatments and patients’ compliance. Methods: The medical records of patients adimitted for the treatment of scarring were retrospectively evaluated. Patient satisfaction with the treatment was assessed via telephone interviews. Each patient also sent recent photographs of their scars. Pre- and Corresponding Author: post-treatment photographs were scored according to the Manchester Scar Scale, and in Berna Aksoy terms of vascularity and scar surface area (modified MSS ). Bahcesehir University, School of Results: The study included 71 patients with a median scar age of 18 days at the time Medicine, Dermatology, Istanbul, treatment was initiated. Mean duration of follow-up was 41 months. The prescribed Turkey [email protected] treatments included onion extract, silicone gel or sheet, and a pressure garment. The patients reported that the treatments were effective, they were satisfied with the treatments, and the treatments were not excessively difficult to apply.
    [Show full text]
  • Dermatofibrosarcoma Protuberans and Dermatofibroma: Dermal Dendrocytomas? a Ultrastructural Study
    Dermatofibrosarcoma Protuberans and Dermatofibroma: Dermal Dendrocytomas? A Ultrastructural Study Hugo Dominguez-Malagon, M.D., Ana Maria Cano-Valdez, M.D. Department of Pathology, Instituto Nacional de Cancerología, Mexico. ABSTRACT population of plump spindled cells devoid of cell processes, these cells contained intracytoplasmic lipid droplets and rare Dermatofibroma (DF) and Dermatofibrosarcoma subplasmalemmal densities but lacked MVB. Protuberans (DFSP) are dermal tumors whose histogenesis has not been well defined to date. The differential diagnosis in most With the ultrastructural characteristics and the constant cases is established in routine H/E sections and may be confirmed expression of CD34 in DFSP, a probable origin in dermal by immunohistochemistry; however there are atypical variants dendrocytes is postulated. The histogenesis of DF remains of DF with less clear histological differences and non-conclusive obscure. immunohistochemical results. In such cases electron microscopy studies may be useful to establish the diagnosis. INTRODUCTION In the present paper the ultrastructural characteristics of 38 The histogenesis or differentiation of cases of DFSP and 10 cases of DF are described in detail, the Dermatofibrosarcoma Protuberans (DFSP) and objective was to identify some features potentially useful for Dermatofibroma (DF) is controversial in the literature. For differential diagnosis, and to identify the possible histogenesis of DFSP diverse origins such as fibroblastic,1 fibro-histiocytic2 both neoplasms. Schwannian,3 myofibroblastic,4 perineurial,5,6 and endoneurial (7) have been postulated. DFSP in all cases was formed by stellate or spindled cells with long, slender, ramified cell processes joined by primitive junctions, Regarding DF, most authors are in agreement of a subplasmalemmal densities were frequently seen in the processes.
    [Show full text]
  • Cutaneous Manifestations of Newborns in Omdurman Maternity Hospital
    ﺑﺴﻢ اﷲ اﻟﺮﺣﻤﻦ اﻟﺮﺣﻴﻢ Cutaneous Manifestations of Newborns in Omdurman Maternity Hospital A thesis submitted in the partial fulfillment of the degree of clinical MD in pediatrics and child health University of Khartoum By DR. AMNA ABDEL KHALIG MOHAMED ATTAR MBBS University of Khartoum Supervisor PROF. SALAH AHMED IBRAHIM MD, FRCP, FRCPCH Department of Pediatrics and Child Health University of Khartoum University of Khartoum The Graduate College Medical and Health Studies Board 2008 Dedication I dedicate my study to the Department of Pediatrics University of Khartoum hoping to be a true addition to neonatal care practice in Sudan. i Acknowledgment I would like to express my gratitude to my supervisor Prof. Salah Ahmed Ibrahim, Professor of Peadiatric and Child Health, who encouraged me throughout the study and provided me with advice and support. I am also grateful to Dr. Osman Suleiman Al-Khalifa, the Dermatologist for his support at the start of the study. Special thanks to the staff at Omdurman Maternity Hospital for their support. I am also grateful to all mothers and newborns without their participation and cooperation this study could not be possible. Love and appreciation to my family for their support, drive and kindness. ii Table of contents Dedication i Acknowledgement ii Table of contents iii English Abstract vii Arabic abstract ix List of abbreviations xi List of tables xiii List of figures xiv Chapter One: Introduction & Literature Review 1.1 The skin of NB 1 1.2 Traumatic lesions 5 1.3 Desquamation 8 1.4 Lanugo hair 9 1.5
    [Show full text]
  • Eyelid Conjunctival Tumors
    EYELID &CONJUNCTIVAL TUMORS PHOTOGRAPHIC ATLAS Dr. Olivier Galatoire Dr. Christine Levy-Gabriel Dr. Mathieu Zmuda EYELID & CONJUNCTIVAL TUMORS 4 EYELID & CONJUNCTIVAL TUMORS Dear readers, All rights of translation, adaptation, or reproduction by any means are reserved in all countries. The reproduction or representation, in whole or in part and by any means, of any of the pages published in the present book without the prior written consent of the publisher, is prohibited and illegal and would constitute an infringement. Only reproductions strictly reserved for the private use of the copier and not intended for collective use, and short analyses and quotations justified by the illustrative or scientific nature of the work in which they are incorporated, are authorized (Law of March 11, 1957 art. 40 and 41 and Criminal Code art. 425). EYELID & CONJUNCTIVAL TUMORS EYELID & CONJUNCTIVAL TUMORS 5 6 EYELID & CONJUNCTIVAL TUMORS Foreword Dr. Serge Morax I am honored to introduce this Photographic Atlas of palpebral and conjunctival tumors,which is the culmination of the close collaboration between Drs. Olivier Galatoire and Mathieu Zmuda of the A. de Rothschild Ophthalmological Foundation and Dr. Christine Levy-Gabriel of the Curie Institute. The subject is now of unquestionable importance and evidently of great interest to Ophthalmologists, whether they are orbital- palpebral specialists or not. Indeed, errors or delays in the diagnosis of tumor pathologies are relatively common and the consequences can be serious in the case of malignant tumors, especially carcinomas. Swift diagnosis and anatomopathological confirmation will lead to a treatment, discussed in multidisciplinary team meetings, ranging from surgery to radiotherapy.
    [Show full text]
  • 15. Dermatology Eponyms
    Dermatology Eponyms DERMATOLOGY EPONYMS – PHENOMEN / SIGN – LEXICON (D) Brzeziński Piotr1, Wollina Uwe2, Poklękowska Katarzyna3, Khamesipour Ali4, Herrero Gonzalez Jose Eugenio5, Bimbi Cesar6, Di Lernia Vito7, Karwan Krzysztof 8 16th Military Support Unit, Ustka, Poland. [email protected] 2Department of Dermatology & Allergology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany [email protected] 3Mazowiecki Branch of the National Health Fund, Warsaw, Poland [email protected] 4Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran [email protected] 5Malalties Ampul.lars i Porfíries, Departament de Dermatologia, Hospital del Mar, Barcelona, Spain [email protected] 6Brazilian Society of Dermatology [email protected] 7Department of Dermatology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy [email protected] 8The Emergency Department, Military Institute of Medicine, Warsaw, Poland [email protected] N Dermatol Online. 2011; 2(3): 158-170 Date of submission: 08.04.2011 / acceptance: 29.05.2011 Conflicts of interest: None DANIELSSEN’S SIGN Anesthetic leprosy. A form of leprosy chiefly affecting the nerves, marked by hyperesthesia succeeded by anesthesia, and by paralysis, ulceration, and various trophic disturbances, terminating in gangrene and mutilation. In 1895 I presented to the Ohio State Medical Society two sisters, natives of Ohio, who manifested appearances of anesthetic leprosy. Synonyms: Danielssen disease, Danielssen-Boeck disease, dry leprosy, trophoneurotic leprosy. OBJAW DANIELSSENA Anesthetic leprosy. Postać trądu głównie wpływająca na nerwy, początkowo charakteryzuje się oznaczone przeczulicą, następcą znieczulicą i paraliŜem, owrzodzeniem i róŜnymi zaburzeniami troficznymi, kończąca się w gangreną i okaleczeniem. W 1895 roku przedstawiono w Ohio State Medical Society dwie siostry z Ohio, u których występowały objawy anesthetic Figure 1.
    [Show full text]
  • Reconstructive
    RECONSTRUCTIVE Differential Diagnosis of Lower Extremity Enlargement in Pediatric Patients Referred with a Diagnosis of Lymphedema Carolyn C. Schook, B.A. Background: There are many causes for a large lower limb in the pediatric age John B. Mulliken, M.D. group. These children are often mislabeled as having lymphedema, and incor- Steven J. Fishman, M.D. rect diagnosis can lead to improper treatment. The purpose of this study was to Ahmad I. Alomari, M.D. determine the differential diagnosis in pediatric patients referred for lower Frederick D. Grant, M.D. extremity “lymphedema” and to clarify management. Arin K. Greene, M.D., Methods: The authors’ Vascular Anomalies Center database was reviewed be- M.M.Sc. tween 1999 and 2010 for patients referred with a diagnosis of lymphedema of Boston, Mass. the lower extremity. Records were studied to determine the correct cause for the enlarged extremity. Alternative diagnoses, sex, age of onset, and imaging studies were also analyzed. Results: A referral diagnosis of lower extremity lymphedema was given to 170 children; however, the condition was confirmed in only 72.9 percent of patients. Forty-six children (27.1 percent) had another disorder: microcystic/macrocystic lymphatic malformation (19.6 percent), noneponymous combined vascular malformation (13.0 percent), capillary malformation (10.9 percent), Klippel- Trenaunay syndrome (10.9 percent), hemihypertrophy (8.7 percent), posttrau- matic swelling (8.7 percent), Parkes Weber syndrome (6.5 percent), lipedema (6.5 percent), venous malformation (4.3 percent), rheumatologic disorder (4.3 percent), infantile hemangioma (2.2 percent), kaposiform hemangioendothe- lioma (2.2 percent), or lipofibromatosis (2.2 percent).
    [Show full text]
  • Orphanet Report Series Rare Diseases Collection
    Marche des Maladies Rares – Alliance Maladies Rares Orphanet Report Series Rare Diseases collection DecemberOctober 2013 2009 List of rare diseases and synonyms Listed in alphabetical order www.orpha.net 20102206 Rare diseases listed in alphabetical order ORPHA ORPHA ORPHA Disease name Disease name Disease name Number Number Number 289157 1-alpha-hydroxylase deficiency 309127 3-hydroxyacyl-CoA dehydrogenase 228384 5q14.3 microdeletion syndrome deficiency 293948 1p21.3 microdeletion syndrome 314655 5q31.3 microdeletion syndrome 939 3-hydroxyisobutyric aciduria 1606 1p36 deletion syndrome 228415 5q35 microduplication syndrome 2616 3M syndrome 250989 1q21.1 microdeletion syndrome 96125 6p subtelomeric deletion syndrome 2616 3-M syndrome 250994 1q21.1 microduplication syndrome 251046 6p22 microdeletion syndrome 293843 3MC syndrome 250999 1q41q42 microdeletion syndrome 96125 6p25 microdeletion syndrome 6 3-methylcrotonylglycinuria 250999 1q41-q42 microdeletion syndrome 99135 6-phosphogluconate dehydrogenase 67046 3-methylglutaconic aciduria type 1 deficiency 238769 1q44 microdeletion syndrome 111 3-methylglutaconic aciduria type 2 13 6-pyruvoyl-tetrahydropterin synthase 976 2,8 dihydroxyadenine urolithiasis deficiency 67047 3-methylglutaconic aciduria type 3 869 2A syndrome 75857 6q terminal deletion 67048 3-methylglutaconic aciduria type 4 79154 2-aminoadipic 2-oxoadipic aciduria 171829 6q16 deletion syndrome 66634 3-methylglutaconic aciduria type 5 19 2-hydroxyglutaric acidemia 251056 6q25 microdeletion syndrome 352328 3-methylglutaconic
    [Show full text]
  • Fundamentals of Dermatology Describing Rashes and Lesions
    Dermatology for the Non-Dermatologist May 30 – June 3, 2018 - 1 - Fundamentals of Dermatology Describing Rashes and Lesions History remains ESSENTIAL to establish diagnosis – duration, treatments, prior history of skin conditions, drug use, systemic illness, etc., etc. Historical characteristics of lesions and rashes are also key elements of the description. Painful vs. painless? Pruritic? Burning sensation? Key descriptive elements – 1- definition and morphology of the lesion, 2- location and the extent of the disease. DEFINITIONS: Atrophy: Thinning of the epidermis and/or dermis causing a shiny appearance or fine wrinkling and/or depression of the skin (common causes: steroids, sudden weight gain, “stretch marks”) Bulla: Circumscribed superficial collection of fluid below or within the epidermis > 5mm (if <5mm vesicle), may be formed by the coalescence of vesicles (blister) Burrow: A linear, “threadlike” elevation of the skin, typically a few millimeters long. (scabies) Comedo: A plugged sebaceous follicle, such as closed (whitehead) & open comedones (blackhead) in acne Crust: Dried residue of serum, blood or pus (scab) Cyst: A circumscribed, usually slightly compressible, round, walled lesion, below the epidermis, may be filled with fluid or semi-solid material (sebaceous cyst, cystic acne) Dermatitis: nonspecific term for inflammation of the skin (many possible causes); may be a specific condition, e.g. atopic dermatitis Eczema: a generic term for acute or chronic inflammatory conditions of the skin. Typically appears erythematous,
    [Show full text]