Structured Oral Examination in Clinical Anaesthesia : Practice Examination Papers
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Cryptococcal Meningoencephalitis with Fulminant Intracranial Hypertension: an Unexpected Cause of Brain Death
Case Report Singapore Med J 2010; 51(8) : e133 Cryptococcal meningoencephalitis with fulminant intracranial hypertension: an unexpected cause of brain death Teo Y K ABSTRACT and later developed fulminant cryptococcal The diagnosis of brain death requires the meningoencephalitis, leading to brain death. presence of unresponsiveness and a lack of receptivity, the absence of movement, CASE REPORT breathing and brain stem reflexes, as well as A 61-year-old Caucasian man presented with a two-week a state of coma in which the cause has been history of generalised malaise, loss of appetite, nausea, identified. We report a case of brain death that headache and unsteady gait with frequent falls. The was diagnosed based on clinical neurological patient was initially seen at a local hospital, where a non- examinations, and supported by the absence contrast computed tomography (CT) of the brain did not of cerebral blood flow on magnetic resonance reveal any abnormality. He was treated symptomatically angiography and electroencephalography with oral analgesics. The patient had end-stage renal demonstrating the characteristic absence failure secondary to hypertension and had undergone of electrical activity. Thorough clinical an autologous renal transplant from his wife one year examination and repeated imaging of the ago. The patient was on prednisolone 10 mg once a brain revealed no apparent clinical cause or day, tacrolimus 3 mg twice a day and mycophenolate mechanism of brain death. We proceeded (mofetil) 1 g twice a day for immunosuppression. He with organ donation of the deceased’s liver had persistent symptoms, as described above and was and corneas. However, postmortem revealed admitted to a tertiary hospital for further evaluation. -
Incremental Costs of Introducing Jet Injection Technology for Delivery of Routine Childhood Vaccinations: Comparative Analysis from Brazil, India, and South Africa
Vaccine 29 (2011) 969–975 Contents lists available at ScienceDirect Vaccine journal homepage: www.elsevier.com/locate/vaccine Incremental costs of introducing jet injection technology for delivery of routine childhood vaccinations: Comparative analysis from Brazil, India, and South Africa Ulla K. Griffiths a,∗, Andreia C. Santos a, Neeti Nundy b, Erica Jacoby b, Dipika Matthias b a London School of Hygiene and Tropical Medicine, Tavistock Place, London WC1H 9SH, UK b PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA article info abstract Article history: Background: Disposable-syringe jet injectors (DSJIs) have the potential to deliver vaccines safely and Received 14 May 2010 affordably to millions of children around the world. We estimated the incremental costs of transitioning Received in revised form 9 November 2010 from needles and syringes to delivering childhood vaccines with DSJIs in Brazil, India, and South Africa. Accepted 15 November 2010 Methods: Two scenarios were assessed: (1) DSJI delivery of all vaccines at current dose and depth; (2) a Available online 27 November 2010 change to intradermal (ID) delivery with DSJIs for hepatitis B and yellow fever vaccines, while the other vaccines are delivered by DSJIs at current dose and depth. The main advantage of ID delivery is that only Keywords: a small fraction of the standard dose may be needed to obtain an immune response similar to that of Vaccine Jet injector subcutaneous or intramuscular injection. Cost categories included were vaccines, injection equipment, Costs waste management, and vaccine transport. Some delivery cost items, such as training and personnel Brazil were excluded as were treatment cost savings caused by a reduction in diseases transmitted due to India unsafe injections. -
Analysis of Fourteen New Cases of Meningovascular Syphilis: Renewed Interest in an Old Problem
Open Access Original Article DOI: 10.7759/cureus.16951 Analysis of Fourteen New Cases of Meningovascular Syphilis: Renewed Interest in an Old Problem Faiza Aziouaz 1 , Fatima Zahra Mabrouki 2 , Mohammed Chraa 3 , Nisrine Louhab 3 , Nawal Adali 3 , Imane Hajjaj 3 , Najib Kissani 3 , Yassine Mebrouk 1 1. Neurology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Oujda, MAR 2. Ophthalmology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Oujda, MAR 3. Neurology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Marrakech, MAR Corresponding author: Faiza Aziouaz, [email protected] Abstract Neurosyphilis (NS) remains a public health problem. Several recent reports suggest a worldwide increase in the incidence of this condition. Various syndromes can occur in NS, such as syphilitic meningitis, meningovascular syphilis, parenchymatous and gummatous neurosyphilis. Syphilis meningovascular will be the focus of this study. We report 14 new observations of meningovascular syphilis. A review of demographic and clinical features, neuroimaging findings, cerebrospinal fluid changes, treatment and outcome, pathophysiology mechanism of meningovascular syphilis are presented. Categories: Neurology, HIV/AIDS, Infectious Disease Keywords: neurosyphilis, stroke, vasculitis, csf, acquired immune deficiency syndrome (aids) Introduction The incidence of stroke is approximately 2.3/1000/year, based on community surveys [1]. Stroke can be a complication of a central nervous system infection [2]. Some infections are more often associated with cerebrovascular complications than others, and the pathogenesis of vascular lesions varies widely from one disease to another [2, 3]. Most of these conditions cause stroke through a mechanism of angitis [4]. This review focuses on meningovascular syphilis as an infectious cause of stroke. -
Locating Critical Care Nurses in Mouth Care: an Institutional Ethnography
Locating Critical Care Nurses in Mouth Care: An Institutional Ethnography by Craig M. Dale A thesis submitted in conformity with the requirements for the degree of Doctor of Philosophy Lawrence S. Bloomberg Faculty of Nursing University of Toronto © Copyright by Craig M. Dale 2013 Locating Critical Care Nurses in Mouth Care: An Institutional Ethnography Craig M. Dale Doctor of Philosophy Lawrence S. Bloomberg Faculty of Nursing University of Toronto 2013 Abstract Intubated and mechanically ventilated patients are vulnerable to respiratory tract infections. In response, the Ontario government has recently mandated surveillance and reporting of ventilator-associated pneumonia (VAP). Serious respiratory infections – and the related costs of additional care – can be reduced, in part, through oral hygiene. However, the literature asserts that oral care is neglected in busy, high-tech settings. Despite these concerns, little research has examined how mouth care happens in the critical care unit. The purpose of this institutional ethnography (IE) was to explore the social organization of mouth care in one critical care unit in Ontario, Canada. As a reflexive and critical method of inquiry, IE focuses on features of everyday life that often go unnoticed. In paying special attention to texts, the ethnographer traces how institutional forces that arrive from outside the practice setting coordinate experiences and activities. Inquiry began in the field with day/night participant observation to better understand the particularities of nursing care for orally intubated patients. Other data sources included reflexive fieldnotes, stakeholder interviews, and transcripts as well as work documents and artifacts. Over time, the analysis shifted from the critical care unit to the larger social context of Ontario’s Critical Care Transformation Strategy (OCCTS). -
General Anesthesia and Altered States of Arousal: a Systems Neuroscience Analysis
General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Brown, Emery N., Patrick L. Purdon, and Christa J. Van Dort. “General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis.” Annual Review of Neuroscience 34, no. 1 (July 21, 2011): 601–628. As Published http://dx.doi.org/10.1146/annurev-neuro-060909-153200 Publisher Annual Reviews Version Author's final manuscript Citable link http://hdl.handle.net/1721.1/86331 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ NIH Public Access Author Manuscript Annu Rev Neurosci. Author manuscript; available in PMC 2012 July 06. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Annu Rev Neurosci. 2011 ; 34: 601–628. doi:10.1146/annurev-neuro-060909-153200. General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis Emery N. Brown1,2,3, Patrick L. Purdon1,2, and Christa J. Van Dort1,2 Emery N. Brown: [email protected]; Patrick L. Purdon: [email protected]; Christa J. Van Dort: [email protected] 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Abstract Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. -
Medical Management of Biological Casualties Handbook
USAMRIID’s MEDICAL MANAGEMENT OF BIOLOGICAL CASUALTIES HANDBOOK Sixth Edition April 2005 U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES FORT DETRICK FREDERICK, MARYLAND Emergency Response Numbers National Response Center: 1-800-424-8802 or (for chem/bio hazards & terrorist events) 1-202-267-2675 National Domestic Preparedness Office: 1-202-324-9025 (for civilian use) Domestic Preparedness Chem/Bio Helpline: 1-410-436-4484 or (Edgewood Ops Center – for military use) DSN 584-4484 USAMRIID’s Emergency Response Line: 1-888-872-7443 CDC'S Emergency Response Line: 1-770-488-7100 Handbook Download Site An Adobe Acrobat Reader (pdf file) version of this handbook can be downloaded from the internet at the following url: http://www.usamriid.army.mil USAMRIID’s MEDICAL MANAGEMENT OF BIOLOGICAL CASUALTIES HANDBOOK Sixth Edition April 2005 Lead Editor Lt Col Jon B. Woods, MC, USAF Contributing Editors CAPT Robert G. Darling, MC, USN LTC Zygmunt F. Dembek, MS, USAR Lt Col Bridget K. Carr, MSC, USAF COL Ted J. Cieslak, MC, USA LCDR James V. Lawler, MC, USN MAJ Anthony C. Littrell, MC, USA LTC Mark G. Kortepeter, MC, USA LTC Nelson W. Rebert, MS, USA LTC Scott A. Stanek, MC, USA COL James W. Martin, MC, USA Comments and suggestions are appreciated and should be addressed to: Operational Medicine Department Attn: MCMR-UIM-O U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Fort Detrick, Maryland 21702-5011 PREFACE TO THE SIXTH EDITION The Medical Management of Biological Casualties Handbook, which has become affectionately known as the "Blue Book," has been enormously successful - far beyond our expectations. -
For Nexplanon® Insertion and Removal G
Wilson et al. Contraception and Reproductive Medicine (2020) 5:1 Contraception and https://doi.org/10.1186/s40834-020-00104-x Reproductive Medicine RESEARCH Open Access Comparison of traditional anesthesia method and jet injector anesthesia method (MadaJet XL®) for Nexplanon® insertion and removal G. Anthony Wilson* , Julie W. Jeter, William S. Dabbs, Amy Barger Stevens, Robert E. Heidel and Shaunta’ M. Chamberlin Abstract Background: This study compared a needle-free anesthesia method with traditional local anesthesia for insertion and removal of Nexplanon® long-acting removable contraceptive device. In our clinic, patients often avoid this highly effective form of contraception due to fear of needles. We sought to determine if patients perceived a difference in pain with the injection, anxiety level or pain with the procedure when local anesthesia was given with a needle v/s a needle-free jet injector device. Methods: Patients were randomly assigned to one of two groups: jet injector or needle lidocaine delivery. Outcomes were ease of use, patient anxiety level, painfulness, and efficacy of anesthesia method. Results: Patient pain perception with administration of jet injector lidocaine was statistically lower than traditional needle with no difference in anxiety or ease of use, or efficacy of the anesthesia. Conclusion: The jet injector device is a reasonable alternative to needle injection delivery of anesthesia prior to insertion/removal of Nexplanon® device. Further studies may determine whether this needle-free alternative for administration of local anesthetic would result in more women choosing Nexplanon® as a contraceptive method. Keywords: Local anesthetic, Nexplanon®, Patient anxiety Background injection of lidocaine differed between the methods of As with many procedures [1, 2], patients often cite a fear delivery, and whether the presence or absence of needles of needles as a major reason to decline Nexplanon® in the anesthesia method affected patient anxiety level. -
Minnesota Ttaps Part 1
MINNESOTA TTAPS PART 1 COURSE NAME: USE OF REFLEXES TO RESOLVE BIOMECHANICS OF CHRONIC NEURO-MUSCULAR-SKELETAL DIAGNOSES COURSE COORDINATOR: ALAN R. BONEBRAKE, DC 630C N CENTRAL EXPY PLANO, TX 75074 COURSE DESCRIPTION: P.A.C.E APPROVED 16 CEs USE OF MYOTATIC, POSTURAL, RECIPROCAL, WITHDRAWAL, AND CROSSED EXTENSOR REFLEXES TO RESOLVE PAIN AND BIOMECHANICS OF CHRONIC NEURO-MUSCULAR- SKELETAL CONDITIONS EDUCATIONAL OBJECTIVES: DISCUSSION OF NORMAL FUNCTION OF MYOTATIC REFLEXES DISCUSSION OF CAUSES OF FACILITATED NERVES RELATING TO WITHDRAWAL REFLEXES CAUSING CHRONIC NEURO-MUSCULAR-SKELETAL CONDITIONS DISCUSSION OF VARIETIES OF WITHDRAWAL REFLEXES DISCUSSION OF AND WORKSHOP OF REINSTATING NORMOTONUS OF HYPERTONIC NERVES AND MUSCLES THROUGH REFLEX INHIBITION UTILIZING MYOTATIC REFLEXES TEACHING METHODS: VERBAL, OVERHEAD PROJECTOR, HANDOUT OF COURSE OUTLINE AND POSSIBLY THE OVERHEADS THAT AREN’T COPYRIGHTED, INSTRUCTOR WATCHING AND CRITIQUING THE STUDENTS PERFORMING THE TREATMENTS RECOMMENDED READING: GUYTON’S TEXTBOOK OF MEDICAL PHYSIOLOGY, 5TH & 9TH ED.; CHUSID’S CORRELATIVE NEUROANATOMY AND FUNCTIONAL NEUROLOGY; MAZION’S ILLUSTRATED MANUAL OF NEURO/ ORTHO/PHYSIOLOGICAL TESTS; THE CHALLENGE OF PAIN BY MELZACK; AND WALL; ACUPUNCTURE, THE ANCIENT CHINESE ART OF HEALING AND HOW IT WORKS SCIENTIFICALLY BY FELIX MANN, MB; CUNNINGHAM’S TEXTBOOK OF ANATOMY, 11TH ED; DORLAND’S ILLUSTRATED MEDICAL DICTIONARY, 25TH ED ~ 1 ~ st 1 hour: All-or-none law The all-or-none law is the principle that the strength by which a nerve or muscle fiber responds to a stimulus is independent of the strength of the stimulus. If that stimulus exceeds the threshold potential, the nerve or muscle fiber will give a complete response; otherwise, there is no response. -
I AMYLIN MEDIATES BRAINSTEM
AMYLIN MEDIATES BRAINSTEM CONTROL OF HEART RATE IN THE DIVING REFLEX A Dissertation Submitted to The Temple University Graduate Board In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy By Fan Yang May, 2012 Examination committee members: Dr. Nae J Dun (advisor), Dept. of Pharmacology, Temple University Dr. Alan Cowan, Dept. of Pharmacology, Temple University Dr. Lee-Yuan Liu-Chen, Dept. of Pharmacology, Temple University Dr. Gabriela Cristina Brailoiu, Dept. of Pharmacology, Temple University Dr. Parkson Lee-Gau Chong, Dept. of Biochemistry, Temple University Dr. Hreday Sapru (external examiner), Depts. of Neurosciences, Neurosurgery & Pharmacology/Physiology, UMDNJ-NJMS. i © 2012 By Fan Yang All Rights Reserved ii ABSTRACT AMYLIN’S ROLE AS A NEUROPEPTIDE IN THE BRAINSTEM Fan Yang Doctor of Philosophy Temple University, 2012 Doctoral Advisory Committee Chair: Nae J Dun, Ph.D. Amylin, or islet amyloid polypeptide is a 37-amino acid member of the calcitonin peptide family. Amylin role in the brainstem and its function in regulating heart rates is unknown. The diving reflex is a powerful autonomic reflex, however no neuropeptides have been described to modulate its function. In this thesis study, amylin expression in the brainstem involving pathways between the trigeminal ganglion and the nucleus ambiguus was visualized and characterized using immunohistochemistry. Its functional role in slowing heart rate and also its involvement in the diving reflex were elucidated using stereotaxic microinjection, whole-cel patch-clamp, and a rat diving model. Immunohistochemical and tract tracing studies in rats revealed amylin expression in trigeminal ganglion cells, which also contained vesicular glutamate transporter 2 positive. -
Technical Considerations for Pen, Jet, and Related Injectors Intended for Use with Drugs and Biological Products
Guidance for Industry and FDA Staff: Technical Considerations for Pen, Jet, and Related Injectors Intended for Use with Drugs and Biological Products Additional copies are available from: Office of Combination Products Office of Special Medical Programs Office of the Commissioner Food and Drug Administration 10903 New Hampshire Avenue, WO-32 Hub 5129 Silver Spring, MD 20993 (Tel) 301-796-8930 (Fax) 301-796-8619 http://www.fda.gov/CombinationProducts/default.htm This document finalizes the draft guidance issued in April 2009. For questions regarding this document, contact the Office of Combination Products at [email protected] or Patricia Y. Love, MD at 301-796-8933 or [email protected] U.S. Department of Health and Human Services Food and Drug Administration Center for Devices and Radiological Health, Center for Drug Evaluation Research, Center for Biologics Evaluation and Research, and Office of Combination Products in the Office of the Commissioner June 2013 Contains Nonbinding Recommendations Table of Contents INTRODUCTION.....................................................................................................................3 BACKGROUND .......................................................................................................................4 SECTION I: SCIENTIFIC AND TECHNICAL CONSIDERATIONS.............................5 A. INJECTOR DESCRIPTION .............................................................................................5 B. DESIGN FEATURES.........................................................................................................9 -
An Introduction to Anaesthesia
What You Need to KNoW about An introduction to anaesthesia Introduction divided into three stages: induction, main- n Central neuraxial block, e.g. spinal or Anaesthetic experience in the undergradu- tenance and emergence. epidural (Figure 1 and Table 1). ate timetable is often very limited so it can In regional anaesthesia, nerve transmis- remain somewhat of a mysterious practice sion is blocked, and the patient may stay Components of a general well into specialist training. This introduc- awake or be sedated or anaesthetized dur- anaesthetic tion to the components of an anaesthetic ing a procedure. Techniques used include: A general anaesthetic always involves an will help readers to get more from clinical n Local anaesthetic field block hypnotic agent, usually an analgesic and attachments in surgery and anaesthetics or n Peripheral nerve block may also include muscle relaxation. The serve as an introduction to the topic for n Nerve plexus block combination is referred to as the ‘triad of novice or non-anaesthetists. anaesthesia’. Figure 1. Schematic vertical longitudinal section The relative importance of each com- Types and sites of anaesthesia of vertebral column and structures encountered ponent depends on surgical and patient The term anaesthesia comes from the when performing central neuraxial blocks. * factors: the intervention planned, site, Greek meaning loss of sensation. negative pressure space filled with fat and surgical access requirement and the Anaesthetic practice has evolved from a venous plexi. † extends to S2, containing degree of pain or stimulation anticipated. need for pain relief and altered conscious- arachnoid mater, CSF, pia mater, spinal cord The technique is tailored to the individu- ness to allow surgery. -
A Look at Closed Claims
Looking at the past to improve A Look at the future: • Ethical considerations preclude direct, Closed Claims prospective experimentation to quantify Where and how can we improve? risks and predict outcomes associated with differences in anesthesia practice. • Prospective nonexperimental studies are prohibitively expensive for rare events, Mary Wojnakowski, CRNA, PhD such as anesthesia incidents. Associate Professor Midwestern University • Retrospective studies are therefore the Nurse Anesthesia Program norm, including examination of closed malpractice claims. Definitions: • Malpractice claim: demand for financial compensation for an injury resulting from medical care. • Closed malpractice claim: claim is dropped or ASA Closed Claims Project settled by the parties or adjudicated by the courts. • Closed Claim Analysis: closed claim file is reviewed by a practicing provider and consists of relevant hospital & medical records, narrative statement from involved healthcare personnel, expert & peer reviews, summaries of depositions, outcome reports, and cost of settlement. • Standardized form for data collection • Initiated in 1984 • Initial findings: unexpected group of claims • Currently contains approx 8000 claims (14 out of 900) that involved sudden dating back to 1962 from 35 cardiac arrest in relatively healthy patients participating insurance carriers. who had received spinal anesthesia. • Excludes claims for dental damage • Sudden appearance of bradycardia & hypotension, which rapidly progressed • Propose: improve patient safety and