|||GET||| Transplanting Commercial Law Reform 1St Edition
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Historical Perspectives of Lung Transplantation: Connecting the Dots
4531 Review Article Historical perspectives of lung transplantation: connecting the dots Tanmay S. Panchabhai1, Udit Chaddha2, Kenneth R. McCurry3, Ross M. Bremner1, Atul C. Mehta4 1Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA; 2Department of Pulmonary and Critical Care Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA; 3Department of Cardiothoracic Surgery, Sydell and Arnold Miller Family Heart and Vascular Institute; 4Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA Contributions: (I) Conception and design: TS Panchabhai, AC Mehta; (II) Administrative support: TS Panchabhai, RM Bremner, AC Mehta; (III) Provision of study materials or patients: TS Panchabhai, U Chaddha; (IV) Collection and assembly of data: TS Panchabhai, U Chaddha, AC Mehta; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Atul C. Mehta, MD, FCCP. Professor of Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Staff Physician, Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. Email: [email protected]. Abstract: Lung transplantation is now a treatment option for many patients with end-stage lung disease. Now 55 years since the first human lung transplant, this is a good time to reflect upon the history of lung transplantation, to recognize major milestones in the field, and to learn from others’ unsuccessful transplant experiences. James Hardy was instrumental in developing experimental thoracic transplantation, performing the first human lung transplant in 1963. George Magovern and Adolph Yates carried out the second human lung transplant a few days later. -
HARBIN. NOVEMBER 2017. Sergio
POWER OVER LIFE AND DEATH Natalie Köhle ARBIN. NOVEMBER 2017. Sergio NESS is NOT in the BRAIN, which seeks HCanavero and Ren Xiaoping 任晓 to prove the existence of an eternal 平 announced that the world’s first hu- soul on the basis of near death experi- man head transplant was ‘imminent’. ence, as well as two guides on seducing They had just completed an eight- women. He also drops flippant refer- een-hour rehearsal on two human ca- ences to Stalin or the Nazi doctor Josef davers, and now claimed to be ready Mengele. for the real deal: the transplant of a human head from a living person with a degenerative disease onto a healthy, but brain-dead, donor body.1 Ren — a US-educated Chinese orthopaedic surgeon, was part of the team that performed the first hand transplant in Louisville in 1999. Canavero, an Italian, and former neu- rosurgeon at the university of Turin, is the more controversial, maverick per- sona of the team. In addition to many respected scientific publications, he Frankenstein’s Monster from The Bride of Frankenstein (1935) published Immortal: Why CONSCIOUS- Source: Commons Wikimedia 276 tor function and sensation. It would 277 also depend on the unproven capacity of the human brain to adjust to — and gain control over — a new body and a new nervous system without suffering debilitating pain or going mad.2 So far, Ren and Canavero have Sergio Canavero transplanted the heads of numerous Source: 诗凯 陆, Flickr lab mice and one monkey, and they Ren and Canavero see the head have also severed and subsequently Power over Life and Death Natalie Köhle transplant, formally known as cepha- mended the spinal cords of several POWER losomatic anastomosis, as the logical dogs. -
Lung Transplantation Adriaan Myburgh
Lung Transplantation Adriaan Myburgh ! UNIVERSITY OF CAPE TOWN ! Department of Anaesthesia and Perioperative Medicine ! ! ! ! ! ! ! Disclosure Jenna Lowe “ Get me to 21” • 4065 Donors Phalo - URE History • 1947: Vladimir Demikhov performs first successful animal lung transplantation • 1963: James Hardy performs first human lung transplantation in Jackson Mississippi 3 December 1967: First Human heart transplant Denise Darvall to Louis Washkansy • 1986: Joel Cooper performs first successful human double lung transplantation • 2001: Stig Steen performed first successful Non Heart Beating lung transplantation • 2007: Stig Steen performs first ex-vivo reconditioning human lung transplantation Recipients Relative contraindications to lung transplantation • Age > 65 years • Critical or unstable condition (eg, shock, ECMO) • Severely limited functional status • Colonization with highly resistant bacteria, fungi or mycobacteria • Severe obesity (BMI > 30 kg/m2) • Severe osteoporosis • Mechanical ventilation • Other significant medical conditions Orens JB et al. J Heart Lung Transplant 2006; 25: 745-55 Contraindications ? Relative contraindications to lung transplantation • Age > 65 years • Critical or unstable condition (eg, shock, ECMO) • Severely limited functional status • Colonization with highly resistant bacteria, fungi or mycobacteria • Severe obesity (BMI > 30 kg/m2) • Severe osteoporosis • Mechanical ventilation • Other significant medical conditions ECMO Bridge-to-transplant Lung assist device (Novalung®) ECMO Strueber M. Curr Opin Organ -
The Morality of Head Transplant: Frankenstein’S Allegory
5 THE MORALITY OF HEAD TRANSPLANT: FRANKENSTEIN’S ALLEGORY Aníbal Monasterio Astobiza1 Abstract: In 1970 Robert J. White (1926-2010) tried to transplant the head of a Rhesus monkey into another monkey’s body. He was in- spired by the work of a Russian scientist, Vladimir Demikhov (1916- 1998), who had conducted similar experiments in dogs. Both Demikhov and White have been successful pioneers of organ transplantation, but their scientific attempts to transplant heads of mammals are often remem- bered as infamous. Both scientists encountered important difficulties in such experiments, including their incapacity to link the spinal cord, which ended up by creating quadriplegic animals. In 2013, neurosurgeon Sergio Canavero claimed his capacity and plan to carry out the first human head 1 I am grateful to the Basque Government sponsorship for carrying out a posdoc- toral research fellowship at the Uehiro Centre for Practical Ethics of the University of Oxford, and to the latter institution for its warm welcome. Also, I would like to thank David Rodríguez-Arias for his invaluable comments and suggestions for the improvement of this paper. As usual, any error is solely the author’s responsibility. This work was carried out within the framework of the following research projects: KONTUZ!: “Responsabilidad causal de la comisión por omisión: Una dilucidadión ético-jurídica de los problemas de la acción indebida” (MINECO FFI2014-53926-R); “La constitución del sujeto en la interacción social: identidad, normas y sentido de la acción desde la perspectiva de la filosofía de la acción, la epistemología y la filosofía experimental” (FFI2015-67569-C2-2-P), and “Artificial Intelligence and Biotechnol- ogy of Moral Enhancement Ethical Aspects” (FFI2016-79000-P). -
Eunuchen Als Sklaven (Kordula Schnegg)
Inhaltsverzeichnis 7 Vorwort (Andreas Exenberger) 15 Körperliche Verstümmelung zur „Wertsteigerung“ – Eunuchen als Sklaven (Kordula Schnegg) 27 Mit Haut und Haar. Der menschliche Körper als Ware im Europa der Frühen Neuzeit (Valentin Gröbner) 39 Der Körper in der Psychiatrie: Psychiatrische Praxis in Tirol in der ersten Hälfte des 19. Jahrhunderts (Maria Heidegger) 59 Zur Geschichte der Organtransplantation (Marlene Hopfgartner) 79 Menschliche Körperteile – Ein Monetarisierungsversuch mittels Schmerzensgeldentscheidungen (Andrea Leiter, Magdalena Thöni, Hannes Winner) 99 Menschliche Eizellen – ein kostbares Gut (Gabriele Werner- Felmayer) 119 Organknappheit? Wie lösen? Eine Zusammenfassung der Podiumsdiskussion am 15. Mai 2008 in Innsbruck (Matthias Stöckl) 133 ANHANG: Verwandlungen. Eine kleine statistische Auswahl, wie Menschen und Körperteile zu Geld werden (Josef Nussbaumer) 151 Die Autorinnen und Autoren Vorwort Einleitende Anmerkungen zum vorliegenden Band Andreas Exenberger Am 15. und 16. Mai 2008 fand in Innsbruck das 2. Wirtschaftshistorische Symposium zum Thema Von Körpermärkten statt. Diese Tagung schloss an die Vorjahresveranstaltung an, die das Thema Von Menschenhandel und Menschenpreisen behandelt hat.1 Während damals der Mensch als Ganzes in seiner Rolle als Sklave/Slavin, Gefangene(r), potentielles Unfallopfer oder Patient(in) im Mittelpunkt stand, ging es diesmal gezielt um den Körper oder Teile des- selben. Solche Körperteile waren immer schon begehrt, heute vielleicht am stärksten in der Medizin, wenn Organe oder Gewebe längst ganz real und teils sogar offen gehandelt werden, oder in der Versicherungswirtschaft, wo ganz natürlich und je nach Bedarf und Bewertung auch Teile von Menschen gegen Schäden versichert werden, wie z.B. die Stimmbänder von Opernsänger(inne)n, die Nasen von Weinkenner(inne)n, die Beine von Fußballern oder der Busen von Popsängerinnen. -
Empires of the Flesh: Tissue and Organ Taboos
File: GOODWIN.meador lecture.FINAL2.doc Created on: 8/18/2009 9:23:00 PM Last Printed: 9/1/2009 10:03:00 AM MEADOR LECTURE SERIES 2007–2008: EMPIRE EMPIRES OF THE FLESH: TISSUE AND ORGAN TABOOS Michele Goodwin* I. EMPIRICAL OVERVIEW...................................................... 1222 A. Bi-Coastal Problem.................................................... 1223 B. Organs .................................................................. 1225 C. Tissues .................................................................. 1231 II. DEFAULT CONSENT RULES AND PRESUMED CONSENT ............... 1235 III. INCENTIVES ................................................................. 1240 A. Tissues ................................................................... 1241 B. Organs .................................................................. 1242 C. Class and Corruption ................................................. 1243 D. Are We Better Off With Incentives? ................................. 1244 IV. CONCLUSION AND A FEW PRAGMATIC CONSIDERATIONS ........... 1246 In each individual the spirit is made flesh, in each one the whole of creation suffers, in each one a Savior is crucified. —Hermann Hesse (1723–1790) And your very flesh shall be a great poem . —Walt Whitman (1819–1892) * Everett Fraser Professor of Law and Professor of Medicine, University of Minnesota. J.D., LL.M. A version of this Essay was delivered as the Daniel Meador Lecture on Empire at the Univer- sity of Alabama School of Law (Oct. 5, 2007). The author is grateful to -
A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program Revised
MESTRADO INTEGRADO MEDICINA A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program Revised Maria Inês dos Reis Rodrigues M 2019 A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program revised Maria Inês dos Reis Magalhães Rodrigues I [email protected] Mestrado Integrado em Medicina Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Orientador: Professor Doutor Humberto José da Silva Machado Professor Associado Convidado do Instituto de Ciências Biomédicas Abel Salazar Assistente Hospitalar Graduado Sénior de Anestesiologia do Centro Hospitalar do Porto Diretor do Serviço de Anestesiologia do Centro Hospitalar do Porto Adjunto da Direção Clínica do Centro Hospitalar do Porto Maio 2019 24 de maio de 2019 Agradecimentos Ao Professor Doutor Humberto Machado pela orientação, disponibilidade, interesse e apoio que sempre demonstrou, indispensáveis para a realização do presente trabalho. Aos meus pais e irmã, pelos valores transmitidos e por toda a ajuda e companheirismo ao longo do meu percurso de vida. i Resumo Introdução: O transplante pulmonar é atualmente uma opção terapêutica para doentes com doença pulmonar terminal. Nos últimos 30 anos verificou-se um constante crescimento na área da transplantação pulmonar e, com o desenvolvimento de novos fármacos imunossupressores e o aperfeiçoamento de técnicas cirúrgicas e de conservação de órgãos, houve um aumento da sobrevivência e da qualidade de vida dos doentes transplantados. Em Portugal, o programa de transplantação pulmonar teve início em 2001 no Hospital Santa Marta, Centro Hospitalar de Lisboa Central. Apesar de ser o único centro de transplantação pulmonar do país, um número crescente de transplantes pulmonares tem vindo a ser realizado, passando de 8 transplantes realizados em 2009 para 34 transplantes realizados em 2017. -
Alternative Therapies for Orthotopic Heart Transplantation
Alternative Therapies for Orthotopic Heart Transplantation Daniel J. Garry, M.D., Ph.D. Medical Grand Rounds, Department of Internal Medicine July 19, 2001 Disclosure: This is to acknowledge that Daniel Garry, M.D., Ph.D. has not disclosed any financial interests or other relationships with commercial concerns related directly or indirectly to this program. Dr. Garry will be discussing off-label uses in his presentation. BIOGRAPHICAL INFORMATION: Daniel J. Garry, M.D., Ph.D. Assistant Professor, Departments of Internal Medicine, Molecular Biology UT Southwestern Medical Center INTERESTS: Congestive Heart Failure/Cardiac Transplantation Basic science mechanisms·of stem cell biology & oxygen metabolism 2 Congestive heart failure (CHF) Therapeutic strategies for heart failure have evolved tremendously over the past several hundred years. Treatment of congestive heart failure (CHF) or what was referred to as "dropsy" was aimed initially at restoring a balance of fundamental elements and humors. In 1683, Thomas Sydenham recommended bleeding, purges, blistering, garlic and wine. Additional treatments were attempted and abandoned after unrewarding anecdotal experiences (i.e. death). Progress regarding the treatment of heart failure was evident with the introduction of amyl nitrate, mercurial diuretics, digitalis glycosides and bed rest in the early 20th century. Medical therapy for heart failure in the 1960's included digitalis, thiazide diuretics (introduced in 1962) and furosemide (introduced in 1965). The utilization of vasodilators for heart failure were implemented in the 1970's (nitroprusside in 1974 and hydralazine in 1977) and the first large, randomized, clinical trial for heart failure was not completed until 1986 (V-HeFf 1). Since then, the design and completion of a number of large, randomized, placebo-controlled clinical trials have established angiotensin-converting enzyme inhibitors and B-adrenergic receptor antagonists as the cornerstones of therapy. -
Lung Transplantation in the Third Millennium Third the in Lung Transplantation in the Third Millennium
AME Medical Book 1A025 1A025 Lung Transplantation in the Third Millennium Transplantation Lung in the Third Millennium Editors: Dirk Van Raemdonck Federico Venuta www.amegroups.com Editors: Federico Venuta Raemdonck Dirk Van Lung Transplantation in the Third Millennium Editors: Dirk Van Raemdonck Federico Venuta AME Publishing Company Room C 16F, Kings Wing Plaza 1, NO. 3 on Kwan Street, Shatin, NT, Hong Kong Information on this title: www.amegroups.com For more information, contact [email protected] Copyright © AME Publishing Company. All rights reserved. This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of AME Publishing Company. First published in 2018 Printed in China by AME Publishing Company Editors: Dirk Van Raemdonck, Federico Venuta Lung Transplantation in the Third Millennium (Hard Cover) ISBN: 978-988-77840-4-3 AME Publishing Company, Hong Kong AME Publishing Company has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. The advice and opinions expressed in this book are solely those of the authors and do not necessarily represent the views or practices of the publisher. No representation is made by the publisher about the suitability of the information contained in this book, and there is no consent, endorsement or recommendation provided by the publisher, express or implied, with regard to its contents. I LUNG TRANSPLANTATION IN THE THIRD MILLENNIUM (FIRST EDITION) EDITORS Greg L. -
Newsletteralumni News of the Newyork-Presbyterian Hospital/Columbia University Department of Surgery Volume 12 Number 1 Spring 2009
NEWSLETTERAlumni News of the NewYork-Presbyterian Hospital/Columbia University Department of Surgery Volume 12 Number 1 Spring 2009 Outliers All requires several iterative improvements and sometimes a leap of faith to cross a chasm of doubt and disappointment. This process is far more comfortable and promising if it is imbued with cross- discipline participation and basic science collaboration. Eric’s early incorporation of internist Ann Marie Schmidt’s basic science group within his Department continues to be a great example of the pro- ductivity that accrues from multidiscipline melding. Several speakers explored training in and acceptance of new techniques. The private practice community led the way in training and early adoption of laparoscopic cholecystectomy, which rapidly supplanted the open operation, despite an early unacceptable inci- dence of bile duct injuries. Mini-thoracotomies arose simultaneous- ly at multiple sites and are now well accepted as viable approaches to the coronaries and interior of the heart; whereas, more than a de- cade after their introduction, video assisted lobectomies for stage I, non-small-cell lung cancer account for <10% of US lobectomies. Os- tensibly, this reluctance reflects fear of uncontrollable bleeding and not doing an adequate cancer operation, neither of which has been a problem in the hands of VATS advocates. The May 8, 2009, 9th John Jones Surgical Day was a bit of an Lesions that are generally refractory to surgical treatment, outlier because the entire day was taken up by a single program, ex- such as glioblastomas and esophageal and pancreas cancers merit cept for a short business meeting and a lovely evening dinner party. -
Surgical Neurology International James I
OPEN ACCESS Editor: Surgical Neurology International James I. Ausman, MD, PhD For entire Editorial Board visit : University of California, Los http://www.surgicalneurologyint.com Angeles, CA, USA Letter to the Editor Ethical considerations regarding head transplantation Anto Čartolovni, Antonio G. Spagnolo Università Cattolica del S. Cuore (Catholic University of the Sacred Heart), "A. Gemelli" School of Medicine, Institute of Bioethics, 1, Largo Francesco Vito, I-00168 Rome, Italy E-mail: *Anto Čartolovni - [email protected]; Antonio G. Spagnolo - [email protected] *Corresponding author Received: 25 March 15 Accepted: 05 May 15 Published: 15 June 15 This article may be cited as: Cartolovni A, Spagnolo AG. Ethical considerations regarding head transplantation. Surg Neurol Int 2015;6:103. Available FREE in open access from: http://www.surgicalneurologyint.com/text.asp?2015/6/1/103/158785 Copyright: © 2015 Čartolovni A. This is an open‑access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Dear Editor, procedure but one for prolonging life, that could even play an essential role in the decision to accept it. Even if We read with interest and some perplexity the article the procedure is accepted in years to come, the subject by the Italian surgeon, Sergio Canavero, on the will be exposed to far greater and unknown risks than the subject of head transplantation commonly known as benefits of the procedure. First of all, assuming that the HEAVEN surgery shorthand for its more full name, spinal cord connection succeeds, the patient will need to “head anastomosis venture” and GEMINI spinal cord take a large amount of immunosupressive drugs and it fusion (SCF) procedure.[2] We find it essential to address is not even clear if the rejection problem will be solved some crucial ethical questions that might even clarify the by taking such drugs. -
Bone Allografts in Dentistry
tistr Den y Malinin et al., Dentistry 2014, 4:2 Dentistry DOI: 10.4172/2161-1122.1000199 ISSN: 2161-1122 Review Article Open Access Bone Allografts in Dentistry: A Review Malinin TI1*, Temple HT2 and Garg AK3,4 1Emeritus Professor of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA 2Professor of Orthopaedics and Director, Tissue Bank, University of Miami Miller School of Medicine, Miami, FL, USA 3Director, Center for Dental Implants of South Florida, Aventura, FL, USA 4Clinical Professor, University of Florida, School of Dentistry, Gainesville, FL, USA Abstract Transplantation of bone allografts is an accepted procedure in dentistry as it is in many surgical specialties. Despite wide acceptance and ready access to a number of bone allografts, there is often insufficient knowledge of the origin of these allografts and the processing methods. This brief review paper summarizes contemporary knowledge of the biologic properties of bone transplants used in dentistry and discusses their safety. It is intended to aid dental practitioners in selecting suitable bone allograft materials for their patients. It does not deal with bone autografts nor does it compare autografts and allografts. Long-term clinical results with allografts processed by different methods are also outside of the scope of this review. Keywords: Bone allografts; Bone banking; Recipient safety; Freeze- The decision making process regarding allograft transplantation is drying; Allograft sterilization; Allograft processing a complex one, and must be based on a fundamental understanding of bone allograft biology. Once familiarity with the subject is gained, Introduction the dental practitioner will be in a position to determine whether or Dental practitioners perform more bone allograft transplants than not transplantation of an allograft will be beneficial for a particular any other surgical specialists.